CPNE8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Calcium-dependent membrane-binding proteins may regulate molecular events at the interface of the cell membrane and cytoplasm. This gene is one of several genes that encode a calcium-dependent protein containing two N-terminal type II C2 domains and an integrin A domain-like sequence in the C-terminus. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1postsynaptic membrane organization (GO:0001941)4.69075611
2respiratory chain complex IV assembly (GO:0008535)4.64095271
3inositol phosphate catabolic process (GO:0071545)4.60209724
4inositol phosphate dephosphorylation (GO:0046855)4.55694923
5phosphorylated carbohydrate dephosphorylation (GO:0046838)4.55694923
6presynaptic membrane assembly (GO:0097105)4.44593501
7cytochrome complex assembly (GO:0017004)4.41305094
8cellular ketone body metabolic process (GO:0046950)4.30045029
9membrane assembly (GO:0071709)4.27351907
10water-soluble vitamin biosynthetic process (GO:0042364)4.27011633
11ketone body metabolic process (GO:1902224)4.21961083
12regulation of Rac protein signal transduction (GO:0035020)4.16786079
13presynaptic membrane organization (GO:0097090)4.00869026
14polyol catabolic process (GO:0046174)3.92575050
15positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003573.89668463
16negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.85554133
17negative regulation of execution phase of apoptosis (GO:1900118)3.83998888
18neuron cell-cell adhesion (GO:0007158)3.71223217
19regulation of axon regeneration (GO:0048679)3.60485418
20regulation of neuron projection regeneration (GO:0070570)3.60485418
21protein localization to synapse (GO:0035418)3.59177270
22vocalization behavior (GO:0071625)3.58328968
23protein prenylation (GO:0018342)3.55063957
24prenylation (GO:0097354)3.55063957
25positive regulation of gluconeogenesis (GO:0045722)3.54103356
26response to pheromone (GO:0019236)3.49169913
27positive regulation of histone H3-K4 methylation (GO:0051571)3.41598573
28glycerophospholipid catabolic process (GO:0046475)3.41101331
29platelet dense granule organization (GO:0060155)3.38277826
30ionotropic glutamate receptor signaling pathway (GO:0035235)3.35254420
31neuron remodeling (GO:0016322)3.34013966
32magnesium ion transport (GO:0015693)3.33383812
33positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic proc3.31136541
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.27167316
35regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.25980406
36regulation of B cell apoptotic process (GO:0002902)3.24123158
37auditory receptor cell differentiation (GO:0042491)3.22843735
38regulation of type B pancreatic cell apoptotic process (GO:2000674)3.22126475
39glutamate receptor signaling pathway (GO:0007215)3.21704456
40detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.20763411
41insulin secretion (GO:0030073)3.20268824
42positive regulation of neurotransmitter secretion (GO:0001956)3.14011619
43protein complex biogenesis (GO:0070271)3.14000583
44regulation of glucokinase activity (GO:0033131)3.13981318
45regulation of hexokinase activity (GO:1903299)3.13981318
46S-adenosylmethionine metabolic process (GO:0046500)3.10999789
47parental behavior (GO:0060746)3.10149267
48negative regulation of systemic arterial blood pressure (GO:0003085)3.01647483
49regulation of neurotransmitter uptake (GO:0051580)3.01606728
50nitric oxide biosynthetic process (GO:0006809)2.98693308
51synapsis (GO:0007129)2.97215641
52regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.97207194
53positive regulation of glycolytic process (GO:0045821)2.96287648
54axoneme assembly (GO:0035082)2.95502244
55serotonin receptor signaling pathway (GO:0007210)2.95024687
56regulation of pigment cell differentiation (GO:0050932)2.94694450
57heme transport (GO:0015886)2.89743813
58mitochondrial respiratory chain complex assembly (GO:0033108)2.87505572
59positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.87247897
60negative regulation of complement activation (GO:0045916)2.86257784
61facial nerve structural organization (GO:0021612)2.86003812
62positive regulation of cardiac muscle cell differentiation (GO:2000727)2.85932529
63signal peptide processing (GO:0006465)2.85553102
64regulation of glutamate secretion (GO:0014048)2.85021135
65neuronal action potential propagation (GO:0019227)2.84532194
66L-phenylalanine catabolic process (GO:0006559)2.84346162
67erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.84346162
68synaptic vesicle docking involved in exocytosis (GO:0016081)2.84312193
69pteridine-containing compound biosynthetic process (GO:0042559)2.82514880
70sleep (GO:0030431)2.82405633
71C-terminal protein lipidation (GO:0006501)2.82021856
72proline transport (GO:0015824)2.81651841
73synaptic vesicle exocytosis (GO:0016079)2.81076601
74positive regulation of glycoprotein biosynthetic process (GO:0010560)2.80191219
75neurotransmitter-gated ion channel clustering (GO:0072578)2.79447088
76regulation of inositol phosphate biosynthetic process (GO:0010919)2.79417385
77positive regulation of calcium ion import (GO:0090280)2.78935567
78positive regulation of protein autophosphorylation (GO:0031954)2.77502814
79negative regulation of synaptic transmission, GABAergic (GO:0032229)2.77341070
80aromatic amino acid family catabolic process (GO:0009074)2.76823503
81rRNA methylation (GO:0031167)2.75674442
82peptide hormone processing (GO:0016486)2.75590749
83xenobiotic catabolic process (GO:0042178)2.75484810
84retinol metabolic process (GO:0042572)2.75283378
85response to histamine (GO:0034776)2.74859105
86neuron-neuron synaptic transmission (GO:0007270)2.74251153
87gamma-aminobutyric acid signaling pathway (GO:0007214)2.74089318
88long-term synaptic potentiation (GO:0060291)2.73338826
89lactate metabolic process (GO:0006089)2.72760931
90branched-chain amino acid catabolic process (GO:0009083)2.72264367
91tryptophan catabolic process (GO:0006569)2.70136695
92indole-containing compound catabolic process (GO:0042436)2.70136695
93indolalkylamine catabolic process (GO:0046218)2.70136695
94atrial cardiac muscle cell action potential (GO:0086014)2.69698716
95negative regulation of neurological system process (GO:0031645)2.68951928
96negative regulation of dendrite morphogenesis (GO:0050774)2.67833462
97negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.67592804
98negative regulation of cation channel activity (GO:2001258)2.67444264
99regulation of excitatory postsynaptic membrane potential (GO:0060079)2.66645642
100regulation of cilium movement (GO:0003352)2.65859494
101regulation of voltage-gated calcium channel activity (GO:1901385)2.65248137
102erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.65052535
103L-phenylalanine metabolic process (GO:0006558)2.65052535
104synaptic transmission, glutamatergic (GO:0035249)2.64588208
105regulation of sulfur metabolic process (GO:0042762)2.63858035
106transferrin transport (GO:0033572)2.59560912
107positive regulation of neurotransmitter transport (GO:0051590)2.59146678
108regulation of dopamine secretion (GO:0014059)2.58548361
109glutamate secretion (GO:0014047)2.58038598
110regulation of postsynaptic membrane potential (GO:0060078)2.56689604
111endosome to melanosome transport (GO:0035646)2.56369869
112endosome to pigment granule transport (GO:0043485)2.56369869
113positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.55682261
114fucose catabolic process (GO:0019317)2.55418449
115L-fucose metabolic process (GO:0042354)2.55418449
116L-fucose catabolic process (GO:0042355)2.55418449
117C-terminal protein amino acid modification (GO:0018410)2.54868238
118response to amphetamine (GO:0001975)2.54366024
119regulation of short-term neuronal synaptic plasticity (GO:0048172)2.53988301
120cullin deneddylation (GO:0010388)2.53437192
121regulation of glutamate receptor signaling pathway (GO:1900449)2.52942232
122cranial nerve structural organization (GO:0021604)2.52586716
123positive regulation of insulin secretion (GO:0032024)2.51601847
124mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.51373232
125eosinophil chemotaxis (GO:0048245)2.50873585
126protein K6-linked ubiquitination (GO:0085020)2.50861136
127negative regulation of cytosolic calcium ion concentration (GO:0051481)2.50623290
128regulation of phospholipase A2 activity (GO:0032429)2.50152779
129behavioral response to pain (GO:0048266)2.49572681
130aggressive behavior (GO:0002118)2.48543482
131iron coordination entity transport (GO:1901678)2.48454536
132sphingomyelin metabolic process (GO:0006684)2.48144312
133nitric oxide mediated signal transduction (GO:0007263)2.47955110
134regulation of vesicle fusion (GO:0031338)2.47541867
135calcium-mediated signaling using intracellular calcium source (GO:0035584)2.47164691
136protein localization to cilium (GO:0061512)2.46514462
137negative regulation of protein activation cascade (GO:2000258)2.46384115
138ferric iron transport (GO:0015682)2.46349995
139trivalent inorganic cation transport (GO:0072512)2.46349995
140L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.45591539
141prostate gland growth (GO:0060736)2.45449467
142positive regulation of synapse assembly (GO:0051965)2.44483571
143regulation of execution phase of apoptosis (GO:1900117)2.43181517
144protein K11-linked deubiquitination (GO:0035871)2.43100400
145DNA deamination (GO:0045006)2.43081062
146alanine transport (GO:0032328)2.43037533
147negative regulation of monooxygenase activity (GO:0032769)2.42681377
148endocrine pancreas development (GO:0031018)2.42598614
149startle response (GO:0001964)2.42563565
150long term synaptic depression (GO:0060292)2.41764007
151extracellular fibril organization (GO:0043206)2.41743366
152indolalkylamine metabolic process (GO:0006586)2.41602429
153inositol phosphate-mediated signaling (GO:0048016)2.41325038
154neuron maturation (GO:0042551)2.40557956
155phagosome maturation (GO:0090382)2.40339018
156negative regulation of nitric oxide biosynthetic process (GO:0045019)2.39785733
157rRNA modification (GO:0000154)2.38930759
158glucosamine-containing compound catabolic process (GO:1901072)2.38925693
159regulation of long-term neuronal synaptic plasticity (GO:0048169)2.38527818
160negative regulation of calcium ion transport into cytosol (GO:0010523)2.36486381
161regulation of acyl-CoA biosynthetic process (GO:0050812)2.36459761
162photoreceptor cell maintenance (GO:0045494)2.35914370
163kidney morphogenesis (GO:0060993)2.35742227
164regulation of synaptic vesicle exocytosis (GO:2000300)2.35320896
165nodal signaling pathway (GO:0038092)2.35291857
166regulation of metalloenzyme activity (GO:0048552)2.34752184
1673-phosphoadenosine 5-phosphosulfate metabolic process (GO:0050427)2.34669828
168keratinocyte development (GO:0003334)2.34470271
169negative regulation of dendrite development (GO:2000171)2.33554333
170dopamine transport (GO:0015872)2.33102391
171behavioral response to cocaine (GO:0048148)2.32993183
172synaptic transmission, dopaminergic (GO:0001963)2.32987086
173serotonin metabolic process (GO:0042428)2.32856858
174fear response (GO:0042596)2.32378979
175cochlea development (GO:0090102)2.31136068
176detection of mechanical stimulus involved in sensory perception (GO:0050974)2.28716404
177righting reflex (GO:0060013)2.25223316
178negative regulation of calcium ion transmembrane transporter activity (GO:1901020)2.24019386
179negative regulation of calcium ion transmembrane transport (GO:1903170)2.24019386
180positive regulation of cellular response to oxidative stress (GO:1900409)2.23973472
181positive regulation of response to oxidative stress (GO:1902884)2.23973472
182regulation of neurotransmitter secretion (GO:0046928)2.23889746
183regulation of synaptic transmission, glutamatergic (GO:0051966)2.23842114
184regulation of synapse assembly (GO:0051963)2.22786273
185response to gravity (GO:0009629)2.22720792
186learning (GO:0007612)2.21973807
187negative regulation of neurotransmitter transport (GO:0051589)2.21425171
188regulation of synaptic plasticity (GO:0048167)2.21346724
189regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.20350381
190regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.20350381
191G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.19555163
192ATP hydrolysis coupled proton transport (GO:0015991)2.16771403
193energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.16771403
194dopamine biosynthetic process (GO:0042416)2.16639144
195female mating behavior (GO:0060180)2.15672603
196innervation (GO:0060384)2.14861834
197positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.14376795
198membrane depolarization (GO:0051899)2.14341765
199positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.12743800

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.23937053
2GBX2_23144817_ChIP-Seq_PC3_Human3.84229965
3EZH2_22144423_ChIP-Seq_EOC_Human3.40104856
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.88310657
5SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.73802029
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73070716
7* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.66379315
8SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.59180151
9EED_16625203_ChIP-ChIP_MESCs_Mouse2.59055388
10SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.51835636
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.49163537
12TAF15_26573619_Chip-Seq_HEK293_Human2.49031128
13ZNF274_21170338_ChIP-Seq_K562_Hela2.44470616
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.43659512
15EZH2_18974828_ChIP-Seq_MESCs_Mouse2.28269485
16RNF2_18974828_ChIP-Seq_MESCs_Mouse2.28269485
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.27868860
18EZH2_27304074_Chip-Seq_ESCs_Mouse2.22479542
19TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.16257147
20BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11365902
21* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.05619033
22P300_19829295_ChIP-Seq_ESCs_Human2.01763761
23* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.01259413
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.97598745
25POU3F2_20337985_ChIP-ChIP_501MEL_Human1.90772124
26TP53_18474530_ChIP-ChIP_U2OS_Human1.88348538
27SALL1_21062744_ChIP-ChIP_HESCs_Human1.88064007
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.85758146
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.84738014
30VDR_22108803_ChIP-Seq_LS180_Human1.84068193
31KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.83579081
32PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.82549165
33SUZ12_27294783_Chip-Seq_ESCs_Mouse1.80153452
34* CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79188030
35CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76642241
36RNF2_27304074_Chip-Seq_ESCs_Mouse1.74347553
37PIAS1_25552417_ChIP-Seq_VCAP_Human1.73891259
38TRIM28_21343339_ChIP-Seq_HEK293_Human1.72309481
39* SMAD4_21799915_ChIP-Seq_A2780_Human1.70960533
40AR_21572438_ChIP-Seq_LNCaP_Human1.69990945
41IKZF1_21737484_ChIP-ChIP_HCT116_Human1.68610473
42EZH2_27294783_Chip-Seq_ESCs_Mouse1.67967875
43EZH2_27294783_Chip-Seq_NPCs_Mouse1.64982090
44* CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.61405491
45PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61039415
46RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.57805262
47FUS_26573619_Chip-Seq_HEK293_Human1.57053701
48NFE2_27457419_Chip-Seq_LIVER_Mouse1.55218166
49* ELK1_19687146_ChIP-ChIP_HELA_Human1.51481284
50HTT_18923047_ChIP-ChIP_STHdh_Human1.49800701
51CBX2_27304074_Chip-Seq_ESCs_Mouse1.48996235
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.47870558
53EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.47110903
54CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.46439482
55TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45977727
56SOX2_19829295_ChIP-Seq_ESCs_Human1.45675073
57NANOG_19829295_ChIP-Seq_ESCs_Human1.45675073
58RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.44816769
59WT1_19549856_ChIP-ChIP_CCG9911_Human1.44190010
60PCGF2_27294783_Chip-Seq_NPCs_Mouse1.43527291
61* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.42599055
62* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.42599055
63* STAT3_23295773_ChIP-Seq_U87_Human1.40984350
64CDX2_22108803_ChIP-Seq_LS180_Human1.38031134
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37870231
66FLI1_27457419_Chip-Seq_LIVER_Mouse1.35419405
67IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.33479359
68CBP_20019798_ChIP-Seq_JUKART_Human1.33479359
69AR_25329375_ChIP-Seq_VCAP_Human1.33096366
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32591243
71CRX_20693478_ChIP-Seq_RETINA_Mouse1.32269288
72CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32099984
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.32009613
74FOXA1_25329375_ChIP-Seq_VCAP_Human1.32009613
75GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.31318451
76SOX2_18555785_Chip-Seq_ESCs_Mouse1.30862731
77FOXA1_21572438_ChIP-Seq_LNCaP_Human1.30680176
78GABP_17652178_ChIP-ChIP_JURKAT_Human1.30656624
79PCGF2_27294783_Chip-Seq_ESCs_Mouse1.29849518
80TP53_22573176_ChIP-Seq_HFKS_Human1.28918613
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.28473854
82ZNF217_24962896_ChIP-Seq_MCF-7_Human1.28419346
83NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.27164323
84* TCF4_23295773_ChIP-Seq_U87_Human1.27089197
85REST_21632747_ChIP-Seq_MESCs_Mouse1.25073735
86P300_18555785_Chip-Seq_ESCs_Mouse1.24518160
87NANOG_18555785_Chip-Seq_ESCs_Mouse1.23888196
88TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23388987
89NR3C1_23031785_ChIP-Seq_PC12_Mouse1.22259391
90IGF1R_20145208_ChIP-Seq_DFB_Human1.22140905
91EST1_17652178_ChIP-ChIP_JURKAT_Human1.22042302
92SMAD3_21741376_ChIP-Seq_EPCs_Human1.21995785
93EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20161019
94SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.19802869
95FOXM1_26456572_ChIP-Seq_MCF-7_Human1.19756084
96EGR1_23403033_ChIP-Seq_LIVER_Mouse1.19637243
97SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18435785
98OCT4_18555785_Chip-Seq_ESCs_Mouse1.18007300
99PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17848474
100NMYC_18555785_Chip-Seq_ESCs_Mouse1.15459750
101TP53_16413492_ChIP-PET_HCT116_Human1.15284965
102RNF2_27304074_Chip-Seq_NSC_Mouse1.14941255
103PRDM14_20953172_ChIP-Seq_ESCs_Human1.14465579
104OCT4_21477851_ChIP-Seq_ESCs_Mouse1.14305952
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.12724750
106FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.12526445
107AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.12241706
108BCAT_22108803_ChIP-Seq_LS180_Human1.12219929
109FLI1_21867929_ChIP-Seq_TH2_Mouse1.11360338
110AHR_22903824_ChIP-Seq_MCF-7_Human1.10623282
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10572777
112E2F1_18555785_Chip-Seq_ESCs_Mouse1.10286508
113SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09935983
114ARNT_22903824_ChIP-Seq_MCF-7_Human1.09749207
115MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.08241125
116CTCF_18555785_Chip-Seq_ESCs_Mouse1.07692310
117KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07537848
118SMAD4_21741376_ChIP-Seq_EPCs_Human1.07157366
119GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.06619212
120* KDM2B_26808549_Chip-Seq_REH_Human1.06511565
121ER_23166858_ChIP-Seq_MCF-7_Human1.06359019
122SRF_21415370_ChIP-Seq_HL-1_Mouse1.06283174
123AR_20517297_ChIP-Seq_VCAP_Human1.05671560
124TP53_20018659_ChIP-ChIP_R1E_Mouse1.05204977
125SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.04831475
126P53_22387025_ChIP-Seq_ESCs_Mouse1.04467454
127PHF8_20622853_ChIP-Seq_HELA_Human1.03740126
128IRF8_22096565_ChIP-ChIP_GC-B_Human1.03405387
129NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03240752
130CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02827166
131RUNX2_22187159_ChIP-Seq_PCA_Human1.02308534
132BP1_19119308_ChIP-ChIP_Hs578T_Human1.01347609
133ZFX_18555785_Chip-Seq_ESCs_Mouse1.01035743
134CJUN_26792858_Chip-Seq_BT549_Human1.00348238
135EWS_26573619_Chip-Seq_HEK293_Human0.98739634
136* JUN_21703547_ChIP-Seq_K562_Human0.98054392
137MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.97748216
138RBPJ_22232070_ChIP-Seq_NCS_Mouse0.97244407
139TCF4_22108803_ChIP-Seq_LS180_Human0.96953532
140TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96597123
141CMYC_18555785_Chip-Seq_ESCs_Mouse0.96564574
142SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96411646
143NR3C1_21868756_ChIP-Seq_MCF10A_Human0.95229994
144GATA2_21666600_ChIP-Seq_HMVEC_Human0.93910208
145EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.93798313
146DROSHA_22980978_ChIP-Seq_HELA_Human0.92486094
147ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.92349878
148SUZ12_18555785_Chip-Seq_ESCs_Mouse0.92042914
149TP63_17297297_ChIP-ChIP_HaCaT_Human0.90973375
150FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89583143
151STAT3_18555785_Chip-Seq_ESCs_Mouse0.88410481

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.90098675
2MP0010234_abnormal_vibrissa_follicle3.85810488
3MP0006054_spinal_hemorrhage3.76906495
4MP0001968_abnormal_touch/_nociception3.61710649
5MP0009780_abnormal_chondrocyte_physiolo3.56703606
6MP0002736_abnormal_nociception_after3.50113011
7MP0009379_abnormal_foot_pigmentation3.36087933
8MP0003195_calcinosis3.10314578
9MP0004859_abnormal_synaptic_plasticity3.09695955
10MP0001188_hyperpigmentation3.02703739
11MP0002735_abnormal_chemical_nociception2.79975412
12MP0004270_analgesia2.55290297
13MP0005409_darkened_coat_color2.54597722
14MP0002139_abnormal_hepatobiliary_system2.53760145
15MP0005171_absent_coat_pigmentation2.45128839
16MP0009745_abnormal_behavioral_response2.36683249
17MP0003635_abnormal_synaptic_transmissio2.35197197
18MP0001501_abnormal_sleep_pattern2.33013589
19MP0001986_abnormal_taste_sensitivity2.21713431
20MP0000569_abnormal_digit_pigmentation2.09966932
21MP0002063_abnormal_learning/memory/cond2.06832798
22MP0006072_abnormal_retinal_apoptosis2.01926627
23MP0002572_abnormal_emotion/affect_behav2.00670590
24MP0003787_abnormal_imprinting1.99080528
25MP0006276_abnormal_autonomic_nervous1.96760657
26MP0002693_abnormal_pancreas_physiology1.93443603
27MP0002734_abnormal_mechanical_nocicepti1.89719252
28MP0002909_abnormal_adrenal_gland1.89433796
29MP0001944_abnormal_pancreas_morphology1.88472461
30MP0010386_abnormal_urinary_bladder1.87831728
31MP0000372_irregular_coat_pigmentation1.77892374
32MP0005174_abnormal_tail_pigmentation1.77574963
33MP0002272_abnormal_nervous_system1.74758096
34MP0001905_abnormal_dopamine_level1.74406740
35MP0010678_abnormal_skin_adnexa1.73350432
36MP0003724_increased_susceptibility_to1.72405931
37MP0002064_seizures1.71447736
38MP0001440_abnormal_grooming_behavior1.71096529
39MP0008877_abnormal_DNA_methylation1.70279153
40MP0001970_abnormal_pain_threshold1.66873928
41MP0001756_abnormal_urination1.64876135
42MP0005220_abnormal_exocrine_pancreas1.62178678
43MP0002067_abnormal_sensory_capabilities1.61932477
44MP0001879_abnormal_lymphatic_vessel1.59862041
45MP0002733_abnormal_thermal_nociception1.55842577
46MP0004215_abnormal_myocardial_fiber1.55371955
47MP0002102_abnormal_ear_morphology1.53808945
48MP0005551_abnormal_eye_electrophysiolog1.53291551
49MP0003786_premature_aging1.50667265
50MP0002876_abnormal_thyroid_physiology1.49692646
51MP0005253_abnormal_eye_physiology1.48183896
52MP0002090_abnormal_vision1.47962145
53MP0005332_abnormal_amino_acid1.46907829
54MP0000681_abnormal_thyroid_gland1.45758004
55MP0006036_abnormal_mitochondrial_physio1.45485276
56MP0005084_abnormal_gallbladder_morpholo1.43090033
57MP0004019_abnormal_vitamin_homeostasis1.41140223
58MP0005367_renal/urinary_system_phenotyp1.40041055
59MP0000516_abnormal_urinary_system1.40041055
60MP0005248_abnormal_Harderian_gland1.36945758
61MP0001542_abnormal_bone_strength1.35148160
62MP0001984_abnormal_olfaction1.35088777
63MP0002138_abnormal_hepatobiliary_system1.33933472
64MP0005365_abnormal_bile_salt1.33928787
65MP0003252_abnormal_bile_duct1.33066874
66MP0003806_abnormal_nucleotide_metabolis1.32638557
67MP0005075_abnormal_melanosome_morpholog1.32113049
68MP0010329_abnormal_lipoprotein_level1.31705699
69MP0002184_abnormal_innervation1.30936757
70MP0005503_abnormal_tendon_morphology1.30270688
71MP0004742_abnormal_vestibular_system1.30088451
72MP0003283_abnormal_digestive_organ1.28338888
73MP0002928_abnormal_bile_duct1.28038577
74MP0003828_pulmonary_edema1.27961484
75MP0009046_muscle_twitch1.27442441
76MP0008875_abnormal_xenobiotic_pharmacok1.26783942
77MP0004484_altered_response_of1.26559555
78MP0002163_abnormal_gland_morphology1.26544871
79MP0001486_abnormal_startle_reflex1.25639059
80MP0000427_abnormal_hair_cycle1.25074114
81MP0002638_abnormal_pupillary_reflex1.23054936
82MP0005646_abnormal_pituitary_gland1.21781201
83MP0008775_abnormal_heart_ventricle1.21312296
84MP0003136_yellow_coat_color1.20685012
85MP0003879_abnormal_hair_cell1.19021063
86MP0000015_abnormal_ear_pigmentation1.18307240
87MP0006292_abnormal_olfactory_placode1.18157365
88MP0002009_preneoplasia1.16215538
89MP0003045_fibrosis1.14507533
90MP0001764_abnormal_homeostasis1.08223816
91MP0003186_abnormal_redox_activity1.07514116
92MP0001661_extended_life_span1.06232531
93MP0003011_delayed_dark_adaptation1.06227970
94MP0002254_reproductive_system_inflammat1.05628860
95MP0004883_abnormal_blood_vessel1.04499361
96MP0004272_abnormal_basement_membrane1.04138100
97MP0002148_abnormal_hypersensitivity_rea1.03533491
98MP0005595_abnormal_vascular_smooth1.01392457
99MP0001502_abnormal_circadian_rhythm1.01193725
100MP0002557_abnormal_social/conspecific_i0.99917299
101MP0003941_abnormal_skin_development0.96959630
102MP0003172_abnormal_lysosome_physiology0.96358417
103MP0005164_abnormal_response_to0.96003651
104MP0002078_abnormal_glucose_homeostasis0.95958150
105MP0001664_abnormal_digestion0.94413812
106MP0000778_abnormal_nervous_system0.94392158
107MP0004510_myositis0.93284448
108MP0001529_abnormal_vocalization0.91643530
109MP0009250_abnormal_appendicular_skeleto0.90923531
110MP0006035_abnormal_mitochondrial_morpho0.89961187
111MP0005187_abnormal_penis_morphology0.89598576
112MP0002332_abnormal_exercise_endurance0.87599432
113MP0005379_endocrine/exocrine_gland_phen0.87580354
114MP0005165_increased_susceptibility_to0.86261830
115MP0000383_abnormal_hair_follicle0.86160012
116MP0008872_abnormal_physiological_respon0.84094394
117MP0001533_abnormal_skeleton_physiology0.83956432
118MP0000230_abnormal_systemic_arterial0.83346735
119MP0003646_muscle_fatigue0.83050838
120MP0005167_abnormal_blood-brain_barrier0.82807627
121MP0003191_abnormal_cellular_cholesterol0.82761439
122MP0001485_abnormal_pinna_reflex0.81715797
123MP0005636_abnormal_mineral_homeostasis0.81675764
124MP0002837_dystrophic_cardiac_calcinosis0.81377058
125MP0000631_abnormal_neuroendocrine_gland0.80907837
126MP0001963_abnormal_hearing_physiology0.80698307
127MP0004924_abnormal_behavior0.80531100
128MP0005386_behavior/neurological_phenoty0.80531100
129MP0003122_maternal_imprinting0.79718006
130MP0000013_abnormal_adipose_tissue0.79716848
131MP0008569_lethality_at_weaning0.79671355
132MP0003121_genomic_imprinting0.78593808
133MP0005085_abnormal_gallbladder_physiolo0.78337810
134MP0005275_abnormal_skin_tensile0.78249033
135MP0002095_abnormal_skin_pigmentation0.77749798
136MP0003950_abnormal_plasma_membrane0.75427009
137MP0004043_abnormal_pH_regulation0.75188195
138MP0004885_abnormal_endolymph0.74876693
139MP0005410_abnormal_fertilization0.74764415
140MP0010368_abnormal_lymphatic_system0.74437116
141MP0000371_diluted_coat_color0.74232538
142MP0002168_other_aberrant_phenotype0.73912703
143MP0005408_hypopigmentation0.73748513
144MP0008874_decreased_physiological_sensi0.72915604
145MP0005310_abnormal_salivary_gland0.72561565
146MP0005645_abnormal_hypothalamus_physiol0.72420931
147MP0002938_white_spotting0.71601384
148MP0005535_abnormal_body_temperature0.71435704
149MP0001346_abnormal_lacrimal_gland0.71399421
150MP0000647_abnormal_sebaceous_gland0.71264295
151MP0005390_skeleton_phenotype0.71090800
152MP0005448_abnormal_energy_balance0.71082674
153MP0005389_reproductive_system_phenotype0.70779791
154MP0000538_abnormal_urinary_bladder0.70762816
155MP0000639_abnormal_adrenal_gland0.70354234
156MP0004085_abnormal_heartbeat0.70161652
157MP0003279_aneurysm0.69408072
158MP0003137_abnormal_impulse_conducting0.67907723
159MP0002229_neurodegeneration0.67784431
160MP0009785_altered_susceptibility_to0.65980828
161MP0003633_abnormal_nervous_system0.64478846
162MP0008260_abnormal_autophagy0.64397087
163MP0000026_abnormal_inner_ear0.63807339
164MP0000678_abnormal_parathyroid_gland0.63723743
165MP0000762_abnormal_tongue_morphology0.63090456
166MP0002249_abnormal_larynx_morphology0.62961446
167MP0000163_abnormal_cartilage_morphology0.62156116
168MP0008004_abnormal_stomach_pH0.60284657
169MP0004858_abnormal_nervous_system0.60187790
170MP0001851_eye_inflammation0.59971057
171MP0002282_abnormal_trachea_morphology0.59826086

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)5.31813794
2Hyperventilation (HP:0002883)4.44487685
3Hypothermia (HP:0002045)4.20872944
4Epileptic encephalopathy (HP:0200134)3.65492026
5Myokymia (HP:0002411)3.57517828
6Intestinal atresia (HP:0011100)3.54673452
7Febrile seizures (HP:0002373)3.49938381
8Atonic seizures (HP:0010819)3.48692108
9Glucose intolerance (HP:0000833)3.39113410
10Abnormality of aromatic amino acid family metabolism (HP:0004338)3.36704459
11Pancreatic cysts (HP:0001737)3.10887011
12Abnormality of vitamin B metabolism (HP:0004340)3.10179816
13Focal seizures (HP:0007359)3.04280452
14Pancreatic fibrosis (HP:0100732)3.02017940
15Hemiparesis (HP:0001269)2.96466920
16Enlarged penis (HP:0000040)2.94965131
17Broad-based gait (HP:0002136)2.87393870
18Hyperglycemia (HP:0003074)2.83461075
19Epiphyseal dysplasia (HP:0002656)2.81629676
20Increased CSF protein (HP:0002922)2.79723537
21Progressive cerebellar ataxia (HP:0002073)2.78834916
22Large for gestational age (HP:0001520)2.77551737
23Congenital malformation of the right heart (HP:0011723)2.77261014
24Double outlet right ventricle (HP:0001719)2.77261014
25Amblyopia (HP:0000646)2.76352850
26Glycosuria (HP:0003076)2.72504916
27Abnormality of urine glucose concentration (HP:0011016)2.72504916
28Abnormal glucose tolerance (HP:0001952)2.70878197
29Vascular calcification (HP:0004934)2.69527123
30Abnormality of the renal cortex (HP:0011035)2.66192021
31Metaphyseal dysplasia (HP:0100255)2.65215338
32Inability to walk (HP:0002540)2.64900522
33Ulnar claw (HP:0001178)2.63402648
34Xerostomia (HP:0000217)2.62743185
35Hematochezia (HP:0002573)2.60536075
36Ketoacidosis (HP:0001993)2.59490555
37Increased CSF lactate (HP:0002490)2.57818972
38Tongue fasciculations (HP:0001308)2.52291619
39Hypoglycemic coma (HP:0001325)2.50862683
40Methylmalonic acidemia (HP:0002912)2.50003437
41Acute encephalopathy (HP:0006846)2.48967291
42Abnormal autonomic nervous system physiology (HP:0012332)2.47710525
43Heterochromia iridis (HP:0001100)2.42678333
44Hyperinsulinemic hypoglycemia (HP:0000825)2.40783789
45Congenital stationary night blindness (HP:0007642)2.40001143
46Abnormality of vitamin metabolism (HP:0100508)2.39095641
47Visual hallucinations (HP:0002367)2.39005423
48Absence seizures (HP:0002121)2.37247393
49Nonprogressive disorder (HP:0003680)2.36921716
50Conjunctival hamartoma (HP:0100780)2.34981283
51Corneal dystrophy (HP:0001131)2.33267466
52Submucous cleft hard palate (HP:0000176)2.33019996
53Abnormality of midbrain morphology (HP:0002418)2.32573539
54Molar tooth sign on MRI (HP:0002419)2.32573539
55Hydroureter (HP:0000072)2.31612018
56Postural tremor (HP:0002174)2.30275166
57Tubular atrophy (HP:0000092)2.29679122
58Abnormality of renal resorption (HP:0011038)2.29138279
59Hepatic necrosis (HP:0002605)2.28735294
60Furrowed tongue (HP:0000221)2.28451585
61Albinism (HP:0001022)2.27876868
62Patchy hypopigmentation of hair (HP:0011365)2.27608064
63Cardiovascular calcification (HP:0011915)2.26158238
64Hamartoma of the eye (HP:0010568)2.24153909
65Abnormal mitochondria in muscle tissue (HP:0008316)2.23765687
66Dialeptic seizures (HP:0011146)2.22713060
67Hypoplasia of the fovea (HP:0007750)2.22654039
68Aplasia/Hypoplasia of the fovea (HP:0008060)2.22654039
69Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.21860483
70Increased hepatocellular lipid droplets (HP:0006565)2.20859240
71Fragile nails (HP:0001808)2.20023111
72Amelogenesis imperfecta (HP:0000705)2.19010492
73Hypoglycemic seizures (HP:0002173)2.16448144
74Delusions (HP:0000746)2.13866084
75Urethral obstruction (HP:0000796)2.13298531
76Neoplasm of the adrenal cortex (HP:0100641)2.13283739
77White forelock (HP:0002211)2.12779538
78Lipid accumulation in hepatocytes (HP:0006561)2.12521873
79Attenuation of retinal blood vessels (HP:0007843)2.12328501
80Constricted visual fields (HP:0001133)2.11996906
81Thickened helices (HP:0000391)2.11863287
82Pancreatic islet-cell hyperplasia (HP:0004510)2.11621202
83Dysautonomia (HP:0002459)2.11616749
84Cerebral edema (HP:0002181)2.11154155
85Abnormality of renal excretion (HP:0011036)2.10684611
86Abnormal drinking behavior (HP:0030082)2.09433971
87Polydipsia (HP:0001959)2.09433971
88Abnormality of the axillary hair (HP:0100134)2.09077405
89Abnormality of secondary sexual hair (HP:0009888)2.09077405
90Insulin-resistant diabetes mellitus (HP:0000831)2.09071826
91Polyphagia (HP:0002591)2.08987452
92Growth hormone excess (HP:0000845)2.08505028
93Nephronophthisis (HP:0000090)2.08314897
94Methylmalonic aciduria (HP:0012120)2.07781107
95Respiratory failure (HP:0002878)2.07408369
96Aqueductal stenosis (HP:0002410)2.07353034
97Medial flaring of the eyebrow (HP:0010747)2.06968703
98Distal lower limb muscle weakness (HP:0009053)2.06851944
99Retinal dysplasia (HP:0007973)2.05692887
100Neonatal short-limb short stature (HP:0008921)2.05526294
101Congenital, generalized hypertrichosis (HP:0004540)2.05311409
102Muscle fibrillation (HP:0010546)2.04560592
103Abnormality of the renal medulla (HP:0100957)2.04414675
104Acute necrotizing encephalopathy (HP:0006965)2.02323196
105Protruding tongue (HP:0010808)2.02057225
106Congenital sensorineural hearing impairment (HP:0008527)2.01967566
107Irregular epiphyses (HP:0010582)2.01921683
108Palpebral edema (HP:0100540)2.01170080
109Vacuolated lymphocytes (HP:0001922)1.99754015
110Renal cortical cysts (HP:0000803)1.98828878
1113-Methylglutaconic aciduria (HP:0003535)1.98371987
112Ketosis (HP:0001946)1.98270798
113Progressive inability to walk (HP:0002505)1.96080911
114Hypertensive crisis (HP:0100735)1.95924947
115Orthostatic hypotension (HP:0001278)1.95775704
116Abnormality of binocular vision (HP:0011514)1.94451587
117Diplopia (HP:0000651)1.94451587
118Aplasia/Hypoplasia of the lens (HP:0008063)1.94032240
119Abnormality of polysaccharide metabolism (HP:0011012)1.94002656
120Abnormality of glycosaminoglycan metabolism (HP:0004371)1.94002656
121Abnormality of mucopolysaccharide metabolism (HP:0011020)1.94002656
122Abnormal rod and cone electroretinograms (HP:0008323)1.93499666
123Genu varum (HP:0002970)1.93113642
124Progressive neurologic deterioration (HP:0002344)1.92953489
125Abnormality of salivation (HP:0100755)1.92880372
126Neuroendocrine neoplasm (HP:0100634)1.92772490
127Action tremor (HP:0002345)1.92762852
128Short tibia (HP:0005736)1.92222756
129Thyroid-stimulating hormone excess (HP:0002925)1.91328124
130Disproportionate short-trunk short stature (HP:0003521)1.91170487
131Anxiety (HP:0000739)1.90908288
132Alveolar cell carcinoma (HP:0006519)1.90594013
133Type II lissencephaly (HP:0007260)1.90405110
134Aplasia/Hypoplasia of the tibia (HP:0005772)1.89947081
135Abnormality of the phalanges of the 2nd finger (HP:0009541)1.89187155
136Mitochondrial inheritance (HP:0001427)1.88287965
137Generalized tonic-clonic seizures (HP:0002069)1.87544781
138Urinary glycosaminoglycan excretion (HP:0003541)1.85287798
139Mucopolysacchariduria (HP:0008155)1.85287798
140Progressive macrocephaly (HP:0004481)1.84632644
141Vitreoretinal degeneration (HP:0000655)1.82930856
142Abnormality of the fovea (HP:0000493)1.82888573
143Abnormal hair whorl (HP:0010721)1.82862220
144Abnormal urine output (HP:0012590)1.81684720
145Palpitations (HP:0001962)1.80928586
146Abolished electroretinogram (ERG) (HP:0000550)1.79480676
147Neoplasm of the adrenal gland (HP:0100631)1.79464335
148Fair hair (HP:0002286)1.79457580
149Onycholysis (HP:0001806)1.79406943
150True hermaphroditism (HP:0010459)1.79304179
151Stomatitis (HP:0010280)1.79033958
152Aplasia/hypoplasia of the uterus (HP:0008684)1.78925288
153Gaze-evoked nystagmus (HP:0000640)1.78746675
154Pheochromocytoma (HP:0002666)1.78123516
155Decreased central vision (HP:0007663)1.77427789
156Prostate neoplasm (HP:0100787)1.77278584
157Bradycardia (HP:0001662)1.77050159
158Fetal akinesia sequence (HP:0001989)1.76976277
159Congenital hepatic fibrosis (HP:0002612)1.76943639
160Abnormal biliary tract physiology (HP:0012439)1.76813463
161Bile duct proliferation (HP:0001408)1.76813463
162Absent speech (HP:0001344)1.76788681
163Agitation (HP:0000713)1.76579180
164Exotropia (HP:0000577)1.74854443
165Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74596626
166Gait imbalance (HP:0002141)1.70258354
167Blue irides (HP:0000635)1.69579276
168Testicular atrophy (HP:0000029)1.69299357
169Renal Fanconi syndrome (HP:0001994)1.68735445
170Follicular hyperkeratosis (HP:0007502)1.68311826
171Prominent supraorbital ridges (HP:0000336)1.68052479
172Flat capital femoral epiphysis (HP:0003370)1.67984012
173J-shaped sella turcica (HP:0002680)1.67758769
174Hypoventilation (HP:0002791)1.67039761
175Mixed hearing impairment (HP:0000410)1.66776459
176Congenital primary aphakia (HP:0007707)1.66765675
177Nephrogenic diabetes insipidus (HP:0009806)1.66726926
178Narrow nasal bridge (HP:0000446)1.65950556
179Abnormality of dental color (HP:0011073)1.64860688
180Absent eyebrow (HP:0002223)1.64166972
181Hepatocellular necrosis (HP:0001404)1.63493269
182Limb dystonia (HP:0002451)1.58893096
183Drooling (HP:0002307)1.57948966
184Excessive salivation (HP:0003781)1.57948966
185Generalized hypopigmentation of hair (HP:0011358)1.57809728
186Hyperthyroidism (HP:0000836)1.56674883
187Reduced subcutaneous adipose tissue (HP:0003758)1.56583507

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.81827472
2MAP3K123.85514875
3RIPK43.85496281
4EPHA43.35808251
5ACVR1B3.23505863
6INSRR3.05901424
7WNK32.93553334
8GRK52.81054216
9EIF2AK32.80327922
10BMPR22.78579935
11NTRK32.55567864
12MAP4K22.51463442
13MAP2K72.28917205
14STK392.17495432
15PLK22.14646060
16FGFR22.10668023
17SIK32.02735977
18OXSR12.01585052
19BMPR1B1.95934573
20EIF2AK11.94354163
21PTK2B1.91663461
22TRIM281.91359971
23MST41.77938990
24GRK71.73373985
25ARAF1.72253537
26TIE11.71196714
27PHKG21.65795185
28PHKG11.65795185
29TNIK1.61884048
30NME11.58877421
31DAPK21.53737322
32MUSK1.53557660
33DAPK11.51016681
34AKT31.43729295
35CAMKK21.39621939
36MYLK1.38706790
37CSNK1G11.36204615
38FER1.32375176
39MKNK11.30313154
40PAK31.26067662
41PLK31.10354079
42STK31.07635485
43CSNK1G21.05043169
44CDK191.04601838
45ADRBK21.04275448
46CSNK1G31.03939277
47PRKCE1.03599096
48MAP3K41.03381414
49PIM21.02839855
50MINK11.01175625
51BCR1.00789811
52CAMK2A0.98108984
53PINK10.96397374
54MKNK20.94016912
55CAMK2B0.93029891
56TAF10.92577839
57FGR0.91820957
58TAOK20.90593455
59STK38L0.89703484
60CSNK1A1L0.88491611
61FES0.86249883
62FGFR30.84815374
63STK240.82872280
64MAP3K140.82761064
65MAPKAPK50.81758452
66CDK80.80416168
67BRSK20.79594338
68NME20.79248751
69SIK20.78739717
70NTRK10.77643380
71TGFBR10.77497225
72ADRBK10.76963501
73MAP2K10.76288155
74STK160.75658497
75MAP2K40.74493359
76ERBB30.73580880
77PLK40.73434849
78MAP3K30.72171451
79EPHA30.71696417
80CCNB10.71315488
81YES10.70385234
82MAPK120.69844301
83MAP3K20.69724902
84MAP3K90.66605892
85MAP3K130.64984904
86MAPK130.64550851
87NLK0.64402549
88PRPF4B0.63816625
89PRKCG0.62613812
90MAP3K10.62350595
91WNK40.62233640
92CDK50.61945669
93CDK30.61682369
94TGFBR20.58403021
95EIF2AK20.58025112
96GRK10.57750168
97CAMK2D0.57587196
98TAOK30.55688858
99DYRK1A0.54922752
100BCKDK0.54405145
101PIK3CA0.54118094
102MST1R0.52818532
103CAMK10.52022321
104MOS0.51699806
105NEK60.51355744
106SGK20.51089437
107EPHB20.50392693
108TEC0.48826953
109MAPK150.48773557
110PRKCI0.48206908
111SYK0.47270016
112NUAK10.47256810
113BRAF0.45269620
114PIK3CG0.44327254
115SGK4940.43649886
116SGK2230.43649886
117STK100.43277724
118WEE10.42335847
119MAP2K60.41929338
120DAPK30.41693431
121PRKG20.41240194
122ZAK0.40955116
123TLK10.40432228
124RAF10.38884501
125PRKAA20.38671327
126IKBKB0.37875355
127STK110.36533541
128IKBKE0.36051329
129PRKACA0.35832034
130TRPM70.33763365
131IRAK10.33500304
132VRK20.33232843
133CSNK1A10.32927427
134PRKD30.32647524
135GSK3A0.32338130
136PRKCD0.32283326
137PRKCQ0.32214534
138FRK0.31852181
139PRKG10.31566149
140VRK10.30974172
141CAMK2G0.30628117
142GRK60.30097104
143AKT20.29687095
144TNK20.28347651
145ABL10.27764392
146KDR0.27667484
147ROCK20.27528069
148PLK10.27386195
149STK40.27260570
150MAPKAPK30.26562448
151CSNK1D0.26431002
152ROCK10.25933079
153BUB10.24990083
154EGFR0.23597311

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049503.61883394
2Sulfur metabolism_Homo sapiens_hsa009203.21639992
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.97018583
4Nicotine addiction_Homo sapiens_hsa050332.90991907
5Collecting duct acid secretion_Homo sapiens_hsa049662.57071054
6Vitamin B6 metabolism_Homo sapiens_hsa007502.48623290
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.40235684
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.32220410
9Folate biosynthesis_Homo sapiens_hsa007902.27921011
10Propanoate metabolism_Homo sapiens_hsa006402.27393032
11Butanoate metabolism_Homo sapiens_hsa006502.27249680
12Long-term potentiation_Homo sapiens_hsa047202.12415862
13Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.11613366
14Synaptic vesicle cycle_Homo sapiens_hsa047212.09588513
15Circadian entrainment_Homo sapiens_hsa047132.07873510
16Amphetamine addiction_Homo sapiens_hsa050312.02150139
17Oxidative phosphorylation_Homo sapiens_hsa001902.00472581
18Salivary secretion_Homo sapiens_hsa049701.89770040
19Renin secretion_Homo sapiens_hsa049241.89533087
20Taste transduction_Homo sapiens_hsa047421.87315956
21Serotonergic synapse_Homo sapiens_hsa047261.85444337
22Selenocompound metabolism_Homo sapiens_hsa004501.84861959
23Glutamatergic synapse_Homo sapiens_hsa047241.81465156
24Olfactory transduction_Homo sapiens_hsa047401.80568729
25Rheumatoid arthritis_Homo sapiens_hsa053231.77052240
26Nitrogen metabolism_Homo sapiens_hsa009101.76196088
27Morphine addiction_Homo sapiens_hsa050321.76013177
28Tryptophan metabolism_Homo sapiens_hsa003801.65610798
29Phototransduction_Homo sapiens_hsa047441.65218231
30Proteasome_Homo sapiens_hsa030501.60543717
31SNARE interactions in vesicular transport_Homo sapiens_hsa041301.58755479
32Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.58546357
33Alzheimers disease_Homo sapiens_hsa050101.55763047
34Vibrio cholerae infection_Homo sapiens_hsa051101.55666877
35Long-term depression_Homo sapiens_hsa047301.55082794
36Dopaminergic synapse_Homo sapiens_hsa047281.55030220
37Ether lipid metabolism_Homo sapiens_hsa005651.53052952
38Calcium signaling pathway_Homo sapiens_hsa040201.47032280
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.46886433
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.41236338
41Fatty acid elongation_Homo sapiens_hsa000621.38770847
42GABAergic synapse_Homo sapiens_hsa047271.38046045
43African trypanosomiasis_Homo sapiens_hsa051431.36022620
44Peroxisome_Homo sapiens_hsa041461.34721201
45Primary bile acid biosynthesis_Homo sapiens_hsa001201.27485620
46Pentose and glucuronate interconversions_Homo sapiens_hsa000401.26654883
47Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.26519087
48Oxytocin signaling pathway_Homo sapiens_hsa049211.26006267
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.25430869
50Cholinergic synapse_Homo sapiens_hsa047251.24985854
51Parkinsons disease_Homo sapiens_hsa050121.24596377
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.22284299
53Gastric acid secretion_Homo sapiens_hsa049711.13664502
54Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.13336123
55Insulin secretion_Homo sapiens_hsa049111.12332218
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11612055
57Basal transcription factors_Homo sapiens_hsa030221.11474094
58Linoleic acid metabolism_Homo sapiens_hsa005911.10924212
59beta-Alanine metabolism_Homo sapiens_hsa004101.10486322
60Aldosterone synthesis and secretion_Homo sapiens_hsa049251.10163988
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.09459103
62Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.07085807
63Cocaine addiction_Homo sapiens_hsa050301.05933038
64Type I diabetes mellitus_Homo sapiens_hsa049401.05888297
65Homologous recombination_Homo sapiens_hsa034401.04523534
66GnRH signaling pathway_Homo sapiens_hsa049121.04118099
67Melanogenesis_Homo sapiens_hsa049161.02811881
68Pancreatic secretion_Homo sapiens_hsa049721.01821172
69Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.01439105
70ABC transporters_Homo sapiens_hsa020101.00690817
71Phagosome_Homo sapiens_hsa041450.99326197
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99101371
73cAMP signaling pathway_Homo sapiens_hsa040240.98794687
74Gap junction_Homo sapiens_hsa045400.95646002
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.95144751
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.94443003
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.93941332
78Huntingtons disease_Homo sapiens_hsa050160.92993578
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92973875
80Retinol metabolism_Homo sapiens_hsa008300.91635309
81Fanconi anemia pathway_Homo sapiens_hsa034600.89105821
82Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88989846
83Chemical carcinogenesis_Homo sapiens_hsa052040.85123994
84Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.84502039
85Caffeine metabolism_Homo sapiens_hsa002320.84457451
86Axon guidance_Homo sapiens_hsa043600.84324558
87Glutathione metabolism_Homo sapiens_hsa004800.84299126
88Dorso-ventral axis formation_Homo sapiens_hsa043200.84122557
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.82093542
90Metabolic pathways_Homo sapiens_hsa011000.78424691
91Ras signaling pathway_Homo sapiens_hsa040140.77108120
92Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77105102
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76910239
94cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76739817
95Cardiac muscle contraction_Homo sapiens_hsa042600.76660879
96Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.75460202
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.75176964
98Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75108607
99Malaria_Homo sapiens_hsa051440.75039246
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.74085106
101Purine metabolism_Homo sapiens_hsa002300.72681804
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.70753735
103Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.70109828
104Protein export_Homo sapiens_hsa030600.70006274
105Pertussis_Homo sapiens_hsa051330.69035151
106Regulation of autophagy_Homo sapiens_hsa041400.69002744
107Lysosome_Homo sapiens_hsa041420.68622007
108Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68393155
109Non-homologous end-joining_Homo sapiens_hsa034500.67799622
110ECM-receptor interaction_Homo sapiens_hsa045120.67074979
111Arginine biosynthesis_Homo sapiens_hsa002200.66751255
112One carbon pool by folate_Homo sapiens_hsa006700.65719068
113Salmonella infection_Homo sapiens_hsa051320.65522774
114Fatty acid metabolism_Homo sapiens_hsa012120.65253389
115Rap1 signaling pathway_Homo sapiens_hsa040150.64499633
116Arachidonic acid metabolism_Homo sapiens_hsa005900.64138665
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.63868686
118Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63413008
119Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.62565741
120RNA degradation_Homo sapiens_hsa030180.61729672
121Mineral absorption_Homo sapiens_hsa049780.60705646
122Ribosome_Homo sapiens_hsa030100.60703146
123Fatty acid degradation_Homo sapiens_hsa000710.59698100
124AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.59273918
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58069178
126Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.57430455
127Glioma_Homo sapiens_hsa052140.57355166
128Estrogen signaling pathway_Homo sapiens_hsa049150.56894162
129Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.56514586
130Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.55939918
131RNA polymerase_Homo sapiens_hsa030200.55894817
132Melanoma_Homo sapiens_hsa052180.55749873
133MAPK signaling pathway_Homo sapiens_hsa040100.55729457
134Platelet activation_Homo sapiens_hsa046110.55569177
135Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.55380287
136Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.53709530
137Other glycan degradation_Homo sapiens_hsa005110.53061529
138Osteoclast differentiation_Homo sapiens_hsa043800.52456604
139VEGF signaling pathway_Homo sapiens_hsa043700.51409095
140Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.50546211
141Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49355487
142Tuberculosis_Homo sapiens_hsa051520.49030167
143Hematopoietic cell lineage_Homo sapiens_hsa046400.48649052
144Choline metabolism in cancer_Homo sapiens_hsa052310.48181093
145Autoimmune thyroid disease_Homo sapiens_hsa053200.48098186
146Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.48027365
147Sphingolipid metabolism_Homo sapiens_hsa006000.47596502
148Allograft rejection_Homo sapiens_hsa053300.47398260
149TNF signaling pathway_Homo sapiens_hsa046680.46659406
150Glycerophospholipid metabolism_Homo sapiens_hsa005640.46199189
151Sphingolipid signaling pathway_Homo sapiens_hsa040710.45813595
152Complement and coagulation cascades_Homo sapiens_hsa046100.45594036
153Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44652468
154Circadian rhythm_Homo sapiens_hsa047100.43615702
155Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.43552297
156N-Glycan biosynthesis_Homo sapiens_hsa005100.43308407
157Glycerolipid metabolism_Homo sapiens_hsa005610.42644556
158Asthma_Homo sapiens_hsa053100.41622055
159Shigellosis_Homo sapiens_hsa051310.40562766
160Dilated cardiomyopathy_Homo sapiens_hsa054140.39771856
161Chemokine signaling pathway_Homo sapiens_hsa040620.38186678
162Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.38177354
163Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37917765
164ErbB signaling pathway_Homo sapiens_hsa040120.37453739

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