

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 5.90783822 |
| 2 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 5.42427584 |
| 3 | regulation of synaptic vesicle exocytosis (GO:2000300) | 5.31474277 |
| 4 | vocalization behavior (GO:0071625) | 5.30812629 |
| 5 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 5.19343494 |
| 6 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 5.17848050 |
| 7 | neuronal action potential propagation (GO:0019227) | 5.16149994 |
| 8 | glutamate secretion (GO:0014047) | 5.06354355 |
| 9 | neurofilament cytoskeleton organization (GO:0060052) | 4.92181446 |
| 10 | regulation of synaptic vesicle transport (GO:1902803) | 4.77755338 |
| 11 | neuron cell-cell adhesion (GO:0007158) | 4.72755014 |
| 12 | synaptic vesicle exocytosis (GO:0016079) | 4.72547995 |
| 13 | synaptic vesicle maturation (GO:0016188) | 4.66248984 |
| 14 | neuronal ion channel clustering (GO:0045161) | 4.66246639 |
| 15 | dendritic spine morphogenesis (GO:0060997) | 4.61650756 |
| 16 | regulation of synapse structural plasticity (GO:0051823) | 4.57022475 |
| 17 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 4.42440021 |
| 18 | sodium ion export (GO:0071436) | 4.41222094 |
| 19 | regulation of glutamate receptor signaling pathway (GO:1900449) | 4.38116179 |
| 20 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 4.37705194 |
| 21 | protein localization to synapse (GO:0035418) | 4.36910432 |
| 22 | presynaptic membrane assembly (GO:0097105) | 4.36117466 |
| 23 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.35525467 |
| 24 | neurotransmitter-gated ion channel clustering (GO:0072578) | 4.34480732 |
| 25 | presynaptic membrane organization (GO:0097090) | 4.29699530 |
| 26 | synaptic transmission, glutamatergic (GO:0035249) | 4.27837679 |
| 27 | positive regulation of neurotransmitter secretion (GO:0001956) | 4.21784989 |
| 28 | positive regulation of synaptic transmission, dopaminergic (GO:0032226) | 4.18612569 |
| 29 | postsynaptic membrane organization (GO:0001941) | 4.14870645 |
| 30 | cerebellar Purkinje cell differentiation (GO:0021702) | 4.13751383 |
| 31 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.06972069 |
| 32 | regulation of neurotransmitter secretion (GO:0046928) | 4.06940278 |
| 33 | neurotransmitter secretion (GO:0007269) | 4.05108197 |
| 34 | locomotory exploration behavior (GO:0035641) | 4.04675773 |
| 35 | glutamate receptor signaling pathway (GO:0007215) | 4.02099231 |
| 36 | cell migration in hindbrain (GO:0021535) | 4.00906571 |
| 37 | neuron-neuron synaptic transmission (GO:0007270) | 3.99861493 |
| 38 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.92890366 |
| 39 | establishment of mitochondrion localization (GO:0051654) | 3.83491597 |
| 40 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.80790331 |
| 41 | cerebellar granule cell differentiation (GO:0021707) | 3.74616784 |
| 42 | positive regulation of neurotransmitter transport (GO:0051590) | 3.69328120 |
| 43 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.67428748 |
| 44 | regulation of neurotransmitter transport (GO:0051588) | 3.67205574 |
| 45 | startle response (GO:0001964) | 3.61733719 |
| 46 | positive regulation of dendritic spine development (GO:0060999) | 3.60724159 |
| 47 | gamma-aminobutyric acid transport (GO:0015812) | 3.57018767 |
| 48 | regulation of postsynaptic membrane potential (GO:0060078) | 3.56328136 |
| 49 | regulation of neuronal synaptic plasticity (GO:0048168) | 3.54483465 |
| 50 | layer formation in cerebral cortex (GO:0021819) | 3.51567056 |
| 51 | central nervous system myelination (GO:0022010) | 3.50611249 |
| 52 | axon ensheathment in central nervous system (GO:0032291) | 3.50611249 |
| 53 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 3.50051883 |
| 54 | mitochondrion transport along microtubule (GO:0047497) | 3.49825088 |
| 55 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 3.49825088 |
| 56 | amino acid import (GO:0043090) | 3.49183003 |
| 57 | positive regulation of dendritic spine morphogenesis (GO:0061003) | 3.48996771 |
| 58 | neuromuscular process controlling posture (GO:0050884) | 3.48390151 |
| 59 | positive regulation of membrane potential (GO:0045838) | 3.47768015 |
| 60 | righting reflex (GO:0060013) | 3.47351378 |
| 61 | cochlea development (GO:0090102) | 3.47092203 |
| 62 | neurotransmitter transport (GO:0006836) | 3.43280820 |
| 63 | cell communication by electrical coupling involved in cardiac conduction (GO:0086064) | 3.42652798 |
| 64 | neuromuscular process controlling balance (GO:0050885) | 3.40987082 |
| 65 | L-amino acid import (GO:0043092) | 3.40037114 |
| 66 | regulation of calcium ion-dependent exocytosis (GO:0017158) | 3.39120423 |
| 67 | auditory behavior (GO:0031223) | 3.37703640 |
| 68 | dendritic spine organization (GO:0097061) | 3.36821459 |
| 69 | potassium ion homeostasis (GO:0055075) | 3.34845945 |
| 70 | long-term memory (GO:0007616) | 3.33050594 |
| 71 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 3.32649965 |
| 72 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.32308792 |
| 73 | retinal cone cell development (GO:0046549) | 3.30597764 |
| 74 | synaptic vesicle endocytosis (GO:0048488) | 3.30093320 |
| 75 | regulation of vesicle fusion (GO:0031338) | 3.27499659 |
| 76 | mechanosensory behavior (GO:0007638) | 3.27246423 |
| 77 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.26870590 |
| 78 | negative regulation of hormone biosynthetic process (GO:0032353) | 3.24717776 |
| 79 | negative regulation of hormone metabolic process (GO:0032351) | 3.24717776 |
| 80 | response to pheromone (GO:0019236) | 3.20645223 |
| 81 | long-term synaptic potentiation (GO:0060291) | 3.18736094 |
| 82 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.17994108 |
| 83 | membrane hyperpolarization (GO:0060081) | 3.17937032 |
| 84 | response to auditory stimulus (GO:0010996) | 3.17391285 |
| 85 | regulation of dendritic spine morphogenesis (GO:0061001) | 3.16214347 |
| 86 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.15134196 |
| 87 | regulation of respiratory system process (GO:0044065) | 3.12708654 |
| 88 | negative regulation of dendrite morphogenesis (GO:0050774) | 3.12135404 |
| 89 | substrate-independent telencephalic tangential interneuron migration (GO:0021843) | 3.11314174 |
| 90 | substrate-independent telencephalic tangential migration (GO:0021826) | 3.11314174 |
| 91 | positive regulation of exocytosis (GO:0045921) | 3.08154925 |
| 92 | regulation of neurotransmitter levels (GO:0001505) | 3.07679093 |
| 93 | regulation of synapse maturation (GO:0090128) | 3.06717145 |
| 94 | phosphorelay signal transduction system (GO:0000160) | 3.05829134 |
| 95 | regulation of respiratory gaseous exchange (GO:0043576) | 3.04936648 |
| 96 | regulation of synaptic plasticity (GO:0048167) | 3.03825469 |
| 97 | pyrimidine nucleobase catabolic process (GO:0006208) | 3.02600576 |
| 98 | exploration behavior (GO:0035640) | 3.00902105 |
| 99 | establishment of synaptic vesicle localization (GO:0097480) | 3.00817434 |
| 100 | synaptic vesicle transport (GO:0048489) | 3.00817434 |
| 101 | cell differentiation in hindbrain (GO:0021533) | 3.00626642 |
| 102 | cell communication by electrical coupling (GO:0010644) | 3.00405714 |
| 103 | glycine transport (GO:0015816) | 3.00082443 |
| 104 | adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191) | 3.00029332 |
| 105 | axonal fasciculation (GO:0007413) | 2.99680354 |
| 106 | positive regulation of synapse assembly (GO:0051965) | 2.99374576 |
| 107 | response to histamine (GO:0034776) | 2.99106116 |
| 108 | positive regulation of synapse maturation (GO:0090129) | 2.98306519 |
| 109 | cAMP catabolic process (GO:0006198) | 2.97380872 |
| 110 | transmission of nerve impulse (GO:0019226) | 2.95690972 |
| 111 | regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371) | 2.95196061 |
| 112 | adult walking behavior (GO:0007628) | 2.93949728 |
| 113 | membrane depolarization (GO:0051899) | 2.91012750 |
| 114 | cellular potassium ion homeostasis (GO:0030007) | 2.89015342 |
| 115 | regulation of synaptic transmission (GO:0050804) | 2.86033922 |
| 116 | calcium ion-dependent exocytosis (GO:0017156) | 2.85742559 |
| 117 | synaptic transmission (GO:0007268) | 2.85734642 |
| 118 | positive regulation of cardiac muscle cell differentiation (GO:2000727) | 2.85467692 |
| 119 | positive regulation of synaptic transmission (GO:0050806) | 2.85386168 |
| 120 | regulation of voltage-gated calcium channel activity (GO:1901385) | 2.83078279 |
| 121 | proline transport (GO:0015824) | 2.80062814 |
| 122 | neuromuscular synaptic transmission (GO:0007274) | 2.79274417 |
| 123 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.78713525 |
| 124 | membrane depolarization during action potential (GO:0086010) | 2.77973309 |
| 125 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.77152388 |
| 126 | serotonin receptor signaling pathway (GO:0007210) | 2.76783133 |
| 127 | neurotransmitter uptake (GO:0001504) | 2.76009590 |
| 128 | negative regulation of dendrite development (GO:2000171) | 2.75991383 |
| 129 | cyclic nucleotide catabolic process (GO:0009214) | 2.75557459 |
| 130 | regulation of synapse assembly (GO:0051963) | 2.75000109 |
| 131 | cAMP-mediated signaling (GO:0019933) | 2.74373534 |
| 132 | learning (GO:0007612) | 2.73417399 |
| 133 | neuron recognition (GO:0008038) | 2.69295325 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 5.30593100 |
| 2 | GBX2_23144817_ChIP-Seq_PC3_Human | 4.19881954 |
| 3 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 3.30975943 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.84970838 |
| 5 | JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.83586629 |
| 6 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.74947791 |
| 7 | EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 2.57051101 |
| 8 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 2.53929309 |
| 9 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.49082064 |
| 10 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.44844678 |
| 11 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.42702834 |
| 12 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.42702834 |
| 13 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 2.41645346 |
| 14 | EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.38805584 |
| 15 | MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human | 2.38686316 |
| 16 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.38262330 |
| 17 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.32114811 |
| 18 | * REST_21632747_ChIP-Seq_MESCs_Mouse | 2.30874659 |
| 19 | JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.28569291 |
| 20 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.24551386 |
| 21 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.23068160 |
| 22 | ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.22448458 |
| 23 | MTF2_20144788_ChIP-Seq_MESCs_Mouse | 2.06206907 |
| 24 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 2.05750810 |
| 25 | * RCOR3_21632747_ChIP-Seq_MESCs_Mouse | 2.04520908 |
| 26 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 2.03291110 |
| 27 | RNF2_27304074_Chip-Seq_ESCs_Mouse | 2.00045988 |
| 28 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 1.97918732 |
| 29 | EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.96834707 |
| 30 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.95882127 |
| 31 | * SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.94427849 |
| 32 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.93201996 |
| 33 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.92008191 |
| 34 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 1.91540942 |
| 35 | * DROSHA_22980978_ChIP-Seq_HELA_Human | 1.91243322 |
| 36 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.85747544 |
| 37 | CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.85714235 |
| 38 | * ZFP281_18757296_ChIP-ChIP_E14_Mouse | 1.75889671 |
| 39 | GATA1_26923725_Chip-Seq_HPCs_Mouse | 1.75651009 |
| 40 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.75417548 |
| 41 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.75127488 |
| 42 | P300_19829295_ChIP-Seq_ESCs_Human | 1.74688237 |
| 43 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.70409146 |
| 44 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.69319553 |
| 45 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.68041363 |
| 46 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.65839739 |
| 47 | CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.64175433 |
| 48 | * REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.63956726 |
| 49 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.62847550 |
| 50 | PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.60942965 |
| 51 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.60697940 |
| 52 | VDR_22108803_ChIP-Seq_LS180_Human | 1.57712658 |
| 53 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.56309139 |
| 54 | AR_21572438_ChIP-Seq_LNCaP_Human | 1.52563605 |
| 55 | KDM2B_26808549_Chip-Seq_K562_Human | 1.49325295 |
| 56 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.48398267 |
| 57 | SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.48241815 |
| 58 | DNAJC2_21179169_ChIP-ChIP_NT2_Human | 1.47472002 |
| 59 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.46889240 |
| 60 | * RARB_27405468_Chip-Seq_BRAIN_Mouse | 1.45519069 |
| 61 | ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.43555524 |
| 62 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.41908986 |
| 63 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.41465214 |
| 64 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.40176791 |
| 65 | FUS_26573619_Chip-Seq_HEK293_Human | 1.40172419 |
| 66 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.39018276 |
| 67 | CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human | 1.37833509 |
| 68 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.37478664 |
| 69 | CTCF_27219007_Chip-Seq_Bcells_Human | 1.36728161 |
| 70 | STAT3_23295773_ChIP-Seq_U87_Human | 1.36620684 |
| 71 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.35385590 |
| 72 | OLIG2_26023283_ChIP-Seq_AINV15_Mouse | 1.33491359 |
| 73 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.32319947 |
| 74 | AR_25329375_ChIP-Seq_VCAP_Human | 1.31104094 |
| 75 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.30876997 |
| 76 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.30068099 |
| 77 | TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.26905492 |
| 78 | TCF4_23295773_ChIP-Seq_U87_Human | 1.26329873 |
| 79 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.26145675 |
| 80 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.23309645 |
| 81 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.22533884 |
| 82 | * SIN3B_21632747_ChIP-Seq_MESCs_Mouse | 1.22430100 |
| 83 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.21951448 |
| 84 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.21231291 |
| 85 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.19569262 |
| 86 | * EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human | 1.19149970 |
| 87 | OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.18900799 |
| 88 | TET1_21490601_ChIP-Seq_MESCs_Mouse | 1.18674272 |
| 89 | UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.17389761 |
| 90 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.17108548 |
| 91 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.16822618 |
| 92 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.16511325 |
| 93 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.15639980 |
| 94 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 1.15486016 |
| 95 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.14665364 |
| 96 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.14315713 |
| 97 | TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.14068106 |
| 98 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.13883808 |
| 99 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.13216151 |
| 100 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.13216151 |
| 101 | MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse | 1.13193528 |
| 102 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.12135264 |
| 103 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.11044811 |
| 104 | CEBPB_26923725_Chip-Seq_MESODERM_Mouse | 1.09661423 |
| 105 | * OCT4_19829295_ChIP-Seq_ESCs_Human | 1.09584484 |
| 106 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.09580143 |
| 107 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.09336069 |
| 108 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.08818076 |
| 109 | KDM2B_26808549_Chip-Seq_REH_Human | 1.08765115 |
| 110 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 1.08727820 |
| 111 | SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.08227978 |
| 112 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.07886787 |
| 113 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.07394593 |
| 114 | RCOR2_21632747_ChIP-Seq_MESCs_Mouse | 1.03992893 |
| 115 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.03394126 |
| 116 | NR3C1_23031785_ChIP-Seq_PC12_Mouse | 1.03153630 |
| 117 | TP53_20018659_ChIP-ChIP_R1E_Mouse | 1.03139480 |
| 118 | ZFP281_27345836_Chip-Seq_ESCs_Mouse | 1.02727503 |
| 119 | SMAD3_22036565_ChIP-Seq_ESCs_Mouse | 1.02690867 |
| 120 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.01401565 |
| 121 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.00814149 |
| 122 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 0.99867619 |
| 123 | PU1_27457419_Chip-Seq_LIVER_Mouse | 0.99185227 |
| 124 | AR_19668381_ChIP-Seq_PC3_Human | 0.99171611 |
| 125 | RING1B_27294783_Chip-Seq_NPCs_Mouse | 0.96004493 |
| 126 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 0.95878003 |
| 127 | KLF4_19829295_ChIP-Seq_ESCs_Human | 0.95759212 |
| 128 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 0.95544365 |
| 129 | SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.93684414 |
| 130 | WT1_25993318_ChIP-Seq_PODOCYTE_Human | 0.93188862 |
| 131 | SMAD3_21741376_ChIP-Seq_ESCs_Human | 0.88026303 |
| 132 | PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse | 0.84126976 |
| 133 | * SMAD4_21741376_ChIP-Seq_ESCs_Human | 0.83099741 |
| 134 | * SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse | 0.81039460 |
| 135 | DPY_21335234_ChIP-Seq_ESCs_Mouse | 0.79075924 |
| 136 | * P68_20966046_ChIP-Seq_HELA_Human | 0.75502551 |
| 137 | NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse | 0.75016226 |
| 138 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 0.74952661 |
| 139 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 0.74847976 |
| 140 | STAT3_18555785_ChIP-Seq_MESCs_Mouse | 0.73904999 |
| 141 | * SMC4_20622854_ChIP-Seq_HELA_Human | 0.73798795 |
| 142 | GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human | 0.72750898 |
| 143 | MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human | 0.70336350 |
| 144 | * LXR_22292898_ChIP-Seq_THP-1_Human | 0.67989949 |
| 145 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 0.66649346 |
| 146 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.65064631 |
| 147 | SETDB1_19884257_ChIP-Seq_MESCs_Mouse | 0.64320184 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 5.05319875 |
| 2 | MP0004859_abnormal_synaptic_plasticity | 4.89262834 |
| 3 | MP0003635_abnormal_synaptic_transmissio | 3.53349701 |
| 4 | MP0001968_abnormal_touch/_nociception | 3.32955725 |
| 5 | MP0009046_muscle_twitch | 3.29456610 |
| 6 | MP0009745_abnormal_behavioral_response | 3.23515032 |
| 7 | MP0005423_abnormal_somatic_nervous | 3.00699691 |
| 8 | MP0004270_analgesia | 2.94653120 |
| 9 | MP0002064_seizures | 2.87003453 |
| 10 | MP0003123_paternal_imprinting | 2.83660904 |
| 11 | MP0003787_abnormal_imprinting | 2.73852145 |
| 12 | MP0002063_abnormal_learning/memory/cond | 2.70183479 |
| 13 | MP0001486_abnormal_startle_reflex | 2.65365941 |
| 14 | MP0002572_abnormal_emotion/affect_behav | 2.64038675 |
| 15 | MP0002736_abnormal_nociception_after | 2.58339040 |
| 16 | MP0002272_abnormal_nervous_system | 2.55345190 |
| 17 | MP0002734_abnormal_mechanical_nocicepti | 2.50327984 |
| 18 | MP0005646_abnormal_pituitary_gland | 2.43716815 |
| 19 | MP0001501_abnormal_sleep_pattern | 2.27819602 |
| 20 | MP0008569_lethality_at_weaning | 2.16511715 |
| 21 | MP0001188_hyperpigmentation | 2.13646349 |
| 22 | MP0002067_abnormal_sensory_capabilities | 2.13369060 |
| 23 | MP0010386_abnormal_urinary_bladder | 2.01939973 |
| 24 | MP0002735_abnormal_chemical_nociception | 2.00797851 |
| 25 | MP0003329_amyloid_beta_deposits | 1.97583150 |
| 26 | MP0006292_abnormal_olfactory_placode | 1.92044658 |
| 27 | MP0001440_abnormal_grooming_behavior | 1.90677341 |
| 28 | MP0002822_catalepsy | 1.85732064 |
| 29 | MP0006276_abnormal_autonomic_nervous | 1.82954768 |
| 30 | MP0003879_abnormal_hair_cell | 1.80320950 |
| 31 | MP0001984_abnormal_olfaction | 1.77587129 |
| 32 | MP0001970_abnormal_pain_threshold | 1.72919305 |
| 33 | MP0002557_abnormal_social/conspecific_i | 1.70539862 |
| 34 | MP0002184_abnormal_innervation | 1.68108654 |
| 35 | MP0002733_abnormal_thermal_nociception | 1.65038351 |
| 36 | MP0001502_abnormal_circadian_rhythm | 1.61480401 |
| 37 | MP0002102_abnormal_ear_morphology | 1.58368611 |
| 38 | MP0002638_abnormal_pupillary_reflex | 1.55376036 |
| 39 | MP0004742_abnormal_vestibular_system | 1.52895612 |
| 40 | MP0005645_abnormal_hypothalamus_physiol | 1.52533629 |
| 41 | MP0001348_abnormal_lacrimal_gland | 1.51304551 |
| 42 | MP0005386_behavior/neurological_phenoty | 1.50930148 |
| 43 | MP0004924_abnormal_behavior | 1.50930148 |
| 44 | MP0000778_abnormal_nervous_system | 1.48659764 |
| 45 | MP0004142_abnormal_muscle_tone | 1.47655774 |
| 46 | MP0001905_abnormal_dopamine_level | 1.47144711 |
| 47 | MP0008877_abnormal_DNA_methylation | 1.36423479 |
| 48 | MP0005171_absent_coat_pigmentation | 1.36178638 |
| 49 | MP0003122_maternal_imprinting | 1.30283979 |
| 50 | MP0000569_abnormal_digit_pigmentation | 1.27373117 |
| 51 | MP0004145_abnormal_muscle_electrophysio | 1.25263389 |
| 52 | MP0003136_yellow_coat_color | 1.23446864 |
| 53 | MP0004811_abnormal_neuron_physiology | 1.22051961 |
| 54 | MP0002066_abnormal_motor_capabilities/c | 1.21702155 |
| 55 | MP0000955_abnormal_spinal_cord | 1.18356205 |
| 56 | MP0002653_abnormal_ependyma_morphology | 1.17858890 |
| 57 | MP0001529_abnormal_vocalization | 1.15530385 |
| 58 | MP0002882_abnormal_neuron_morphology | 1.15482143 |
| 59 | MP0001963_abnormal_hearing_physiology | 1.14542677 |
| 60 | MP0008872_abnormal_physiological_respon | 1.13492825 |
| 61 | MP0009780_abnormal_chondrocyte_physiolo | 1.12227289 |
| 62 | MP0005551_abnormal_eye_electrophysiolog | 1.11857390 |
| 63 | MP0003633_abnormal_nervous_system | 1.11709332 |
| 64 | MP0001485_abnormal_pinna_reflex | 1.11341373 |
| 65 | MP0008789_abnormal_olfactory_epithelium | 1.10229886 |
| 66 | MP0003890_abnormal_embryonic-extraembry | 1.05439058 |
| 67 | MP0005499_abnormal_olfactory_system | 1.01488767 |
| 68 | MP0005394_taste/olfaction_phenotype | 1.01488767 |
| 69 | MP0003631_nervous_system_phenotype | 1.00435249 |
| 70 | MP0005410_abnormal_fertilization | 1.00075273 |
| 71 | MP0000015_abnormal_ear_pigmentation | 0.97867863 |
| 72 | MP0001986_abnormal_taste_sensitivity | 0.95044249 |
| 73 | MP0000604_amyloidosis | 0.92791260 |
| 74 | MP0003121_genomic_imprinting | 0.89696632 |
| 75 | MP0005623_abnormal_meninges_morphology | 0.86579646 |
| 76 | MP0000026_abnormal_inner_ear | 0.85367959 |
| 77 | MP0002752_abnormal_somatic_nervous | 0.84742769 |
| 78 | MP0002163_abnormal_gland_morphology | 0.84585299 |
| 79 | MP0000631_abnormal_neuroendocrine_gland | 0.83466599 |
| 80 | MP0003718_maternal_effect | 0.83460579 |
| 81 | MP0002152_abnormal_brain_morphology | 0.83222155 |
| 82 | MP0002009_preneoplasia | 0.82905474 |
| 83 | MP0000566_synostosis | 0.82584043 |
| 84 | MP0004858_abnormal_nervous_system | 0.81853540 |
| 85 | MP0001177_atelectasis | 0.78834967 |
| 86 | MP0004085_abnormal_heartbeat | 0.74846300 |
| 87 | MP0002229_neurodegeneration | 0.74679380 |
| 88 | MP0002876_abnormal_thyroid_physiology | 0.74101246 |
| 89 | MP0002090_abnormal_vision | 0.73619883 |
| 90 | MP0002160_abnormal_reproductive_system | 0.72415914 |
| 91 | MP0005253_abnormal_eye_physiology | 0.71213080 |
| 92 | MP0002069_abnormal_eating/drinking_beha | 0.71147178 |
| 93 | MP0005535_abnormal_body_temperature | 0.70074177 |
| 94 | MP0005084_abnormal_gallbladder_morpholo | 0.69903871 |
| 95 | MP0001664_abnormal_digestion | 0.69218483 |
| 96 | MP0004885_abnormal_endolymph | 0.68961792 |
| 97 | MP0003861_abnormal_nervous_system | 0.68644073 |
| 98 | MP0001299_abnormal_eye_distance/ | 0.68197420 |
| 99 | MP0003183_abnormal_peptide_metabolism | 0.67261973 |
| 100 | MP0003632_abnormal_nervous_system | 0.67224919 |
| 101 | MP0001346_abnormal_lacrimal_gland | 0.66001582 |
| 102 | MP0003634_abnormal_glial_cell | 0.65055088 |
| 103 | MP0005409_darkened_coat_color | 0.64633276 |
| 104 | MP0002127_abnormal_cardiovascular_syste | 0.63932857 |
| 105 | MP0008874_decreased_physiological_sensi | 0.62066525 |
| 106 | MP0004484_altered_response_of | 0.61327303 |
| 107 | MP0005379_endocrine/exocrine_gland_phen | 0.61116318 |
| 108 | MP0005167_abnormal_blood-brain_barrier | 0.60501297 |
| 109 | MP0003137_abnormal_impulse_conducting | 0.60475544 |
| 110 | MP0006072_abnormal_retinal_apoptosis | 0.59568729 |
| 111 | MP0002277_abnormal_respiratory_mucosa | 0.59076441 |
| 112 | MP0002751_abnormal_autonomic_nervous | 0.58663613 |
| 113 | MP0003646_muscle_fatigue | 0.57123619 |
| 114 | MP0004215_abnormal_myocardial_fiber | 0.57091346 |
| 115 | MP0002161_abnormal_fertility/fecundity | 0.54952726 |
| 116 | MP0008004_abnormal_stomach_pH | 0.54802962 |
| 117 | MP0003690_abnormal_glial_cell | 0.54747252 |
| 118 | MP0004133_heterotaxia | 0.52902462 |
| 119 | MP0002909_abnormal_adrenal_gland | 0.52563062 |
| 120 | MP0002928_abnormal_bile_duct | 0.52513482 |
| 121 | MP0000920_abnormal_myelination | 0.52445289 |
| 122 | MP0003698_abnormal_male_reproductive | 0.51823612 |
| 123 | MP0003075_altered_response_to | 0.49053408 |
| 124 | MP0005195_abnormal_posterior_eye | 0.47250139 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 8.08458168 |
| 2 | Febrile seizures (HP:0002373) | 5.66503328 |
| 3 | Epileptic encephalopathy (HP:0200134) | 5.56925752 |
| 4 | Focal seizures (HP:0007359) | 5.06731045 |
| 5 | Atonic seizures (HP:0010819) | 4.99549498 |
| 6 | Myokymia (HP:0002411) | 4.73243572 |
| 7 | Progressive cerebellar ataxia (HP:0002073) | 4.54571719 |
| 8 | Gaze-evoked nystagmus (HP:0000640) | 3.85667522 |
| 9 | Hyperventilation (HP:0002883) | 3.83805562 |
| 10 | Torticollis (HP:0000473) | 3.73963247 |
| 11 | Broad-based gait (HP:0002136) | 3.69820598 |
| 12 | Neurofibrillary tangles (HP:0002185) | 3.64954662 |
| 13 | Absence seizures (HP:0002121) | 3.59032897 |
| 14 | Generalized tonic-clonic seizures (HP:0002069) | 3.54778096 |
| 15 | Visual hallucinations (HP:0002367) | 3.53686987 |
| 16 | Spastic gait (HP:0002064) | 3.50390368 |
| 17 | Focal dystonia (HP:0004373) | 3.38375018 |
| 18 | Dialeptic seizures (HP:0011146) | 3.32953951 |
| 19 | Abnormality of the corticospinal tract (HP:0002492) | 3.23187867 |
| 20 | Apathy (HP:0000741) | 3.00495127 |
| 21 | Craniofacial dystonia (HP:0012179) | 2.98578358 |
| 22 | Cerebral hypomyelination (HP:0006808) | 2.92256510 |
| 23 | Absent/shortened dynein arms (HP:0200106) | 2.91611265 |
| 24 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 2.91611265 |
| 25 | Intention tremor (HP:0002080) | 2.91191492 |
| 26 | Fetal akinesia sequence (HP:0001989) | 2.90264939 |
| 27 | Action tremor (HP:0002345) | 2.89922804 |
| 28 | Diminished motivation (HP:0000745) | 2.89275339 |
| 29 | Dysdiadochokinesis (HP:0002075) | 2.80950448 |
| 30 | Cerebral inclusion bodies (HP:0100314) | 2.73873546 |
| 31 | Abnormality of the lower motor neuron (HP:0002366) | 2.73090270 |
| 32 | Protruding tongue (HP:0010808) | 2.72310628 |
| 33 | Primitive reflexes (palmomental, snout, glabellar) (HP:0002476) | 2.69381610 |
| 34 | Abnormal hair whorl (HP:0010721) | 2.64948348 |
| 35 | Neuronal loss in central nervous system (HP:0002529) | 2.62233936 |
| 36 | Urinary urgency (HP:0000012) | 2.60945939 |
| 37 | Poor eye contact (HP:0000817) | 2.59039989 |
| 38 | Genetic anticipation (HP:0003743) | 2.58588580 |
| 39 | Hand muscle atrophy (HP:0009130) | 2.57501355 |
| 40 | Bradykinesia (HP:0002067) | 2.53087092 |
| 41 | Tetraplegia (HP:0002445) | 2.52046896 |
| 42 | Hypothermia (HP:0002045) | 2.46385299 |
| 43 | Gait imbalance (HP:0002141) | 2.46348386 |
| 44 | Annular pancreas (HP:0001734) | 2.43971474 |
| 45 | Abnormality of binocular vision (HP:0011514) | 2.42017676 |
| 46 | Diplopia (HP:0000651) | 2.42017676 |
| 47 | Inability to walk (HP:0002540) | 2.40349380 |
| 48 | Medial flaring of the eyebrow (HP:0010747) | 2.38960965 |
| 49 | Amblyopia (HP:0000646) | 2.38590171 |
| 50 | Abnormal eating behavior (HP:0100738) | 2.37411204 |
| 51 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.36314891 |
| 52 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.36314891 |
| 53 | Nephrogenic diabetes insipidus (HP:0009806) | 2.35363263 |
| 54 | Drooling (HP:0002307) | 2.35204116 |
| 55 | Excessive salivation (HP:0003781) | 2.35204116 |
| 56 | Agitation (HP:0000713) | 2.34320247 |
| 57 | Peripheral hypomyelination (HP:0007182) | 2.34021773 |
| 58 | Congenital primary aphakia (HP:0007707) | 2.33665911 |
| 59 | Lower limb muscle weakness (HP:0007340) | 2.31591644 |
| 60 | Truncal ataxia (HP:0002078) | 2.29981779 |
| 61 | Impaired smooth pursuit (HP:0007772) | 2.28954442 |
| 62 | Papilledema (HP:0001085) | 2.28950119 |
| 63 | Dysmetria (HP:0001310) | 2.26335807 |
| 64 | Abnormal ciliary motility (HP:0012262) | 2.26162100 |
| 65 | Delusions (HP:0000746) | 2.24438307 |
| 66 | Hemiparesis (HP:0001269) | 2.24256919 |
| 67 | Pancreatic fibrosis (HP:0100732) | 2.20956252 |
| 68 | Urinary bladder sphincter dysfunction (HP:0002839) | 2.19570477 |
| 69 | Absent speech (HP:0001344) | 2.19263760 |
| 70 | Sleep apnea (HP:0010535) | 2.14444571 |
| 71 | EEG with generalized epileptiform discharges (HP:0011198) | 2.11521509 |
| 72 | Mutism (HP:0002300) | 2.10975509 |
| 73 | Morphological abnormality of the pyramidal tract (HP:0002062) | 2.10057761 |
| 74 | Abnormal pancreas size (HP:0012094) | 2.09997023 |
| 75 | CNS hypomyelination (HP:0003429) | 2.09762487 |
| 76 | Amyotrophic lateral sclerosis (HP:0007354) | 2.09347570 |
| 77 | Hepatoblastoma (HP:0002884) | 2.04857753 |
| 78 | Hemiplegia (HP:0002301) | 2.04067281 |
| 79 | Anomalous pulmonary venous return (HP:0010772) | 2.03636790 |
| 80 | Hypsarrhythmia (HP:0002521) | 2.03095543 |
| 81 | Dysmetric saccades (HP:0000641) | 2.01520374 |
| 82 | Neonatal hypoglycemia (HP:0001998) | 2.01467701 |
| 83 | Inappropriate behavior (HP:0000719) | 1.99172569 |
| 84 | Spastic tetraplegia (HP:0002510) | 1.98384502 |
| 85 | Upper limb amyotrophy (HP:0009129) | 1.98108321 |
| 86 | Distal upper limb amyotrophy (HP:0007149) | 1.98108321 |
| 87 | Failure to thrive in infancy (HP:0001531) | 1.97808930 |
| 88 | Stereotypic behavior (HP:0000733) | 1.96412910 |
| 89 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 1.95604334 |
| 90 | Clonus (HP:0002169) | 1.95289770 |
| 91 | Poor suck (HP:0002033) | 1.95080942 |
| 92 | Abnormal respiratory epithelium morphology (HP:0012253) | 1.94410645 |
| 93 | Abnormal respiratory motile cilium morphology (HP:0005938) | 1.94410645 |
| 94 | Anxiety (HP:0000739) | 1.93617954 |
| 95 | Blue irides (HP:0000635) | 1.93345513 |
| 96 | Abnormality of salivation (HP:0100755) | 1.93175632 |
| 97 | True hermaphroditism (HP:0010459) | 1.92571207 |
| 98 | Genital tract atresia (HP:0001827) | 1.92380990 |
| 99 | Poor coordination (HP:0002370) | 1.90992909 |
| 100 | Abnormality of ocular smooth pursuit (HP:0000617) | 1.90462457 |
| 101 | Abnormal respiratory motile cilium physiology (HP:0012261) | 1.89189192 |
| 102 | Limb dystonia (HP:0002451) | 1.88061233 |
| 103 | Akinesia (HP:0002304) | 1.86209586 |
| 104 | Spastic tetraparesis (HP:0001285) | 1.85499347 |
| 105 | Nephronophthisis (HP:0000090) | 1.84867647 |
| 106 | Abnormality of the labia minora (HP:0012880) | 1.84663897 |
| 107 | Generalized hypopigmentation of hair (HP:0011358) | 1.84509297 |
| 108 | Decreased central vision (HP:0007663) | 1.83396498 |
| 109 | Thickened helices (HP:0000391) | 1.83369484 |
| 110 | Osteomalacia (HP:0002749) | 1.80800315 |
| 111 | Insomnia (HP:0100785) | 1.80108455 |
| 112 | Bradycardia (HP:0001662) | 1.79132428 |
| 113 | Specific learning disability (HP:0001328) | 1.78847730 |
| 114 | Abnormal social behavior (HP:0012433) | 1.78641805 |
| 115 | Impaired social interactions (HP:0000735) | 1.78641805 |
| 116 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.77983086 |
| 117 | Scanning speech (HP:0002168) | 1.77376565 |
| 118 | Retinal atrophy (HP:0001105) | 1.77366515 |
| 119 | Vaginal atresia (HP:0000148) | 1.76366598 |
| 120 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 1.75452210 |
| 121 | Polyphagia (HP:0002591) | 1.75200255 |
| 122 | Depression (HP:0000716) | 1.74478068 |
| 123 | Ankle clonus (HP:0011448) | 1.72980164 |
| 124 | Epileptiform EEG discharges (HP:0011182) | 1.71858889 |
| 125 | Esotropia (HP:0000565) | 1.69219451 |
| 126 | Supranuclear gaze palsy (HP:0000605) | 1.68131405 |
| 127 | Impaired vibration sensation in the lower limbs (HP:0002166) | 1.67139781 |
| 128 | Nonprogressive disorder (HP:0003680) | 1.66229917 |
| 129 | Status epilepticus (HP:0002133) | 1.65578126 |
| 130 | Retinal dysplasia (HP:0007973) | 1.65105973 |
| 131 | Incomplete penetrance (HP:0003829) | 1.63637540 |
| 132 | Chronic hepatic failure (HP:0100626) | 1.63257496 |
| 133 | Abnormality of incisor morphology (HP:0011063) | 1.61762176 |
| 134 | Postural instability (HP:0002172) | 1.61685719 |
| 135 | Fair hair (HP:0002286) | 1.61598535 |
| 136 | Impaired vibratory sensation (HP:0002495) | 1.61199146 |
| 137 | Optic nerve hypoplasia (HP:0000609) | 1.60484441 |
| 138 | Progressive inability to walk (HP:0002505) | 1.60398418 |
| 139 | Aplasia of the phalanges of the hand (HP:0009802) | 1.60363757 |
| 140 | Aplasia involving bones of the extremities (HP:0009825) | 1.60363757 |
| 141 | Aplasia involving bones of the upper limbs (HP:0009823) | 1.60363757 |
| 142 | Obstructive sleep apnea (HP:0002870) | 1.59454173 |
| 143 | Gastroesophageal reflux (HP:0002020) | 1.55872962 |
| 144 | Conical tooth (HP:0000698) | 1.54898698 |
| 145 | Abnormality of saccadic eye movements (HP:0000570) | 1.53380737 |
| 146 | Pancreatic cysts (HP:0001737) | 1.52597218 |
| 147 | Ulnar claw (HP:0001178) | 1.52474714 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CASK | 5.05469341 |
| 2 | NTRK3 | 3.49909978 |
| 3 | MAP2K7 | 3.34260078 |
| 4 | EPHA4 | 3.13043323 |
| 5 | MAP3K12 | 2.98608742 |
| 6 | MAP3K4 | 2.77193490 |
| 7 | DAPK2 | 2.59965788 |
| 8 | TNIK | 2.42038563 |
| 9 | CDK19 | 2.16550472 |
| 10 | MAP3K9 | 2.11577035 |
| 11 | CCNB1 | 2.10005789 |
| 12 | AKT3 | 2.06182107 |
| 13 | PLK2 | 1.96294769 |
| 14 | PRPF4B | 1.81708511 |
| 15 | NTRK2 | 1.81080988 |
| 16 | PAK6 | 1.76551780 |
| 17 | MAPK13 | 1.75239069 |
| 18 | RIPK4 | 1.71524924 |
| 19 | MAP2K4 | 1.65710395 |
| 20 | BMPR2 | 1.57560897 |
| 21 | TYRO3 | 1.56380991 |
| 22 | STK38 | 1.53758463 |
| 23 | MINK1 | 1.52274990 |
| 24 | MAP3K11 | 1.49146161 |
| 25 | MARK1 | 1.44123285 |
| 26 | CAMKK2 | 1.43971312 |
| 27 | OXSR1 | 1.43556811 |
| 28 | GRK5 | 1.39678579 |
| 29 | SGK2 | 1.38597063 |
| 30 | DAPK1 | 1.37195601 |
| 31 | SIK3 | 1.32297901 |
| 32 | NEK6 | 1.29170495 |
| 33 | CDK3 | 1.25111245 |
| 34 | CSNK1G2 | 1.23212284 |
| 35 | SGK494 | 1.21891762 |
| 36 | SGK223 | 1.21891762 |
| 37 | PINK1 | 1.21373106 |
| 38 | CAMKK1 | 1.21168835 |
| 39 | PHKG2 | 1.15685851 |
| 40 | PHKG1 | 1.15685851 |
| 41 | DYRK2 | 1.11325544 |
| 42 | STK38L | 1.08254087 |
| 43 | ZAK | 1.07488127 |
| 44 | MUSK | 1.04937227 |
| 45 | CDK5 | 1.04015741 |
| 46 | SIK2 | 0.99778761 |
| 47 | MAP3K13 | 0.97773820 |
| 48 | PRKCG | 0.96844043 |
| 49 | ARAF | 0.94694823 |
| 50 | MAPKAPK5 | 0.91329016 |
| 51 | CAMK2A | 0.88427124 |
| 52 | BRAF | 0.88057567 |
| 53 | TNK2 | 0.86800131 |
| 54 | ADRBK2 | 0.86462558 |
| 55 | GRK7 | 0.86261757 |
| 56 | CAMK1 | 0.86041665 |
| 57 | CAMK1D | 0.83280192 |
| 58 | NTRK1 | 0.81425759 |
| 59 | UHMK1 | 0.80438809 |
| 60 | ICK | 0.79817311 |
| 61 | ALK | 0.78912836 |
| 62 | MYLK | 0.78497246 |
| 63 | CDC42BPA | 0.77660644 |
| 64 | PKN1 | 0.76986909 |
| 65 | CDK18 | 0.76088367 |
| 66 | FES | 0.75155881 |
| 67 | PRKCE | 0.72380601 |
| 68 | CDK15 | 0.71878354 |
| 69 | CSNK1G3 | 0.69716435 |
| 70 | SGK3 | 0.69409438 |
| 71 | RAF1 | 0.68231253 |
| 72 | SGK1 | 0.67908320 |
| 73 | CSNK1A1L | 0.66319132 |
| 74 | PRKCZ | 0.66296643 |
| 75 | RIPK1 | 0.65126413 |
| 76 | CAMK1G | 0.64265332 |
| 77 | CDK11A | 0.63965216 |
| 78 | CAMK2B | 0.63194441 |
| 79 | MARK2 | 0.62200455 |
| 80 | DMPK | 0.60166187 |
| 81 | PNCK | 0.59442699 |
| 82 | KSR1 | 0.55985340 |
| 83 | CSNK1E | 0.55534265 |
| 84 | AURKA | 0.55511888 |
| 85 | STK11 | 0.55431316 |
| 86 | PLK4 | 0.55333380 |
| 87 | TAOK2 | 0.55221538 |
| 88 | PAK3 | 0.53384053 |
| 89 | PRKD3 | 0.53309577 |
| 90 | DYRK1A | 0.52944618 |
| 91 | WNK1 | 0.52498226 |
| 92 | BCR | 0.51975014 |
| 93 | PRKCI | 0.51947619 |
| 94 | CDK14 | 0.51918036 |
| 95 | MAP3K6 | 0.51723287 |
| 96 | LATS2 | 0.51397176 |
| 97 | TXK | 0.51154666 |
| 98 | CAMK2G | 0.49160973 |
| 99 | BMPR1B | 0.49050981 |
| 100 | LMTK2 | 0.47849361 |
| 101 | MAPK7 | 0.46406641 |
| 102 | PRKCH | 0.46205662 |
| 103 | TAOK1 | 0.45789881 |
| 104 | CSNK1G1 | 0.45743513 |
| 105 | LIMK1 | 0.45733983 |
| 106 | KSR2 | 0.45120746 |
| 107 | PDK1 | 0.44879758 |
| 108 | RPS6KA3 | 0.44626041 |
| 109 | DYRK1B | 0.44424476 |
| 110 | CAMK4 | 0.42647848 |
| 111 | GRK1 | 0.42030674 |
| 112 | MKNK2 | 0.40826461 |
| 113 | STK16 | 0.40734597 |
| 114 | RPS6KA2 | 0.39757896 |
| 115 | MAPK10 | 0.39671255 |
| 116 | PLK3 | 0.38669947 |
| 117 | YES1 | 0.37634430 |
| 118 | ADRBK1 | 0.37552623 |
| 119 | MAP3K14 | 0.37320155 |
| 120 | PTK2B | 0.35759280 |
| 121 | FYN | 0.34600178 |
| 122 | VRK1 | 0.34545840 |
| 123 | PRKG1 | 0.34498633 |
| 124 | PRKACA | 0.34207652 |
| 125 | BRSK1 | 0.33005676 |
| 126 | PAK1 | 0.32849567 |
| 127 | INSRR | 0.32772299 |
| 128 | DAPK3 | 0.32760514 |
| 129 | CSNK1D | 0.32319305 |
| 130 | MOS | 0.31647002 |
| 131 | MAPK12 | 0.30802723 |
| 132 | TRIM28 | 0.30678657 |
| 133 | PRKCA | 0.30408310 |
| 134 | DYRK3 | 0.30137380 |
| 135 | CSNK1A1 | 0.30023427 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.36994284 |
| 2 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 3.47932497 |
| 3 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.85684368 |
| 4 | Morphine addiction_Homo sapiens_hsa05032 | 2.85584383 |
| 5 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.72912199 |
| 6 | Circadian entrainment_Homo sapiens_hsa04713 | 2.67097745 |
| 7 | GABAergic synapse_Homo sapiens_hsa04727 | 2.56395116 |
| 8 | Olfactory transduction_Homo sapiens_hsa04740 | 2.54267185 |
| 9 | Amphetamine addiction_Homo sapiens_hsa05031 | 2.28964229 |
| 10 | Taste transduction_Homo sapiens_hsa04742 | 2.23564135 |
| 11 | Long-term potentiation_Homo sapiens_hsa04720 | 2.20275787 |
| 12 | Salivary secretion_Homo sapiens_hsa04970 | 2.16105278 |
| 13 | Serotonergic synapse_Homo sapiens_hsa04726 | 2.08208032 |
| 14 | Insulin secretion_Homo sapiens_hsa04911 | 1.98225081 |
| 15 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.84124740 |
| 16 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 1.82703188 |
| 17 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.76691489 |
| 18 | Renin secretion_Homo sapiens_hsa04924 | 1.72471221 |
| 19 | Long-term depression_Homo sapiens_hsa04730 | 1.71539803 |
| 20 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.71502292 |
| 21 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.68692737 |
| 22 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.58450505 |
| 23 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.51743502 |
| 24 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.50507675 |
| 25 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.41872612 |
| 26 | Phototransduction_Homo sapiens_hsa04744 | 1.39416859 |
| 27 | Cocaine addiction_Homo sapiens_hsa05030 | 1.36696473 |
| 28 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 1.31386225 |
| 29 | GnRH signaling pathway_Homo sapiens_hsa04912 | 1.29105707 |
| 30 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.19608599 |
| 31 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 1.17861009 |
| 32 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 1.16162666 |
| 33 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.16021205 |
| 34 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 1.14692249 |
| 35 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 1.14208133 |
| 36 | Circadian rhythm_Homo sapiens_hsa04710 | 1.10917121 |
| 37 | Gap junction_Homo sapiens_hsa04540 | 1.09294401 |
| 38 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 1.08566816 |
| 39 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.04438066 |
| 40 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 1.03284265 |
| 41 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.01258002 |
| 42 | Axon guidance_Homo sapiens_hsa04360 | 0.97686816 |
| 43 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.96319578 |
| 44 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.92767503 |
| 45 | Parkinsons disease_Homo sapiens_hsa05012 | 0.90895973 |
| 46 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.88890921 |
| 47 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.87684627 |
| 48 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.85654398 |
| 49 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.85354761 |
| 50 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.84357102 |
| 51 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.84248831 |
| 52 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.83110864 |
| 53 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.81897024 |
| 54 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 0.80065693 |
| 55 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.76824352 |
| 56 | Melanogenesis_Homo sapiens_hsa04916 | 0.76388032 |
| 57 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.74878692 |
| 58 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.74427371 |
| 59 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.73972962 |
| 60 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 0.72519042 |
| 61 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.71704073 |
| 62 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.71020802 |
| 63 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.70593407 |
| 64 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.69519547 |
| 65 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.69408746 |
| 66 | Carbohydrate digestion and absorption_Homo sapiens_hsa04973 | 0.69373768 |
| 67 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.68432747 |
| 68 | Bile secretion_Homo sapiens_hsa04976 | 0.67569004 |
| 69 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.66726447 |
| 70 | Glioma_Homo sapiens_hsa05214 | 0.63175613 |
| 71 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.59014685 |
| 72 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.57273919 |
| 73 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.56652939 |
| 74 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.56446825 |
| 75 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.56223248 |
| 76 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.55871425 |
| 77 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.53877276 |
| 78 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.52238728 |
| 79 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 0.51378355 |
| 80 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.51263591 |
| 81 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.50511282 |
| 82 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.48395092 |
| 83 | Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650 | 0.47826341 |
| 84 | Graft-versus-host disease_Homo sapiens_hsa05332 | 0.45395664 |
| 85 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.44477779 |
| 86 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.42958242 |
| 87 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.40723138 |
| 88 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.40542806 |
| 89 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.36776994 |
| 90 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.36287463 |
| 91 | Basal transcription factors_Homo sapiens_hsa03022 | 0.36275522 |
| 92 | Melanoma_Homo sapiens_hsa05218 | 0.36002111 |
| 93 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.35210807 |
| 94 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.35032746 |
| 95 | Alcoholism_Homo sapiens_hsa05034 | 0.34191275 |
| 96 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.34037294 |
| 97 | Alzheimers disease_Homo sapiens_hsa05010 | 0.33012273 |
| 98 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.32782934 |
| 99 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.32712810 |
| 100 | Mineral absorption_Homo sapiens_hsa04978 | 0.30480667 |
| 101 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.30015571 |
| 102 | Phagosome_Homo sapiens_hsa04145 | 0.29914119 |
| 103 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.28491741 |
| 104 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.28300510 |
| 105 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.28253366 |
| 106 | Prion diseases_Homo sapiens_hsa05020 | 0.27827840 |
| 107 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.27588917 |
| 108 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.25726796 |
| 109 | Purine metabolism_Homo sapiens_hsa00230 | 0.25348874 |
| 110 | Huntingtons disease_Homo sapiens_hsa05016 | 0.25156838 |
| 111 | Endocytosis_Homo sapiens_hsa04144 | 0.24738909 |
| 112 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.23176545 |
| 113 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.21117017 |
| 114 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.17414076 |
| 115 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 0.16624749 |
| 116 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.16070426 |

