CPO

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a member of the metallocarboxypeptidase gene family. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)9.37467069
2lipoprotein transport (GO:0042953)8.25414117
3regulation of guanylate cyclase activity (GO:0031282)8.09771329
4NADH metabolic process (GO:0006734)7.59347346
5epoxygenase P450 pathway (GO:0019373)7.58230154
6fat-soluble vitamin biosynthetic process (GO:0042362)7.45511841
7regulation of bile acid biosynthetic process (GO:0070857)6.92714001
8intestinal absorption (GO:0050892)6.63322397
9positive regulation of guanylate cyclase activity (GO:0031284)6.43664019
10fructose metabolic process (GO:0006000)6.13776698
11hormone catabolic process (GO:0042447)5.98436895
12regulation of systemic arterial blood pressure by hormone (GO:0001990)5.76652449
13regulation of systemic arterial blood pressure mediated by a chemical signal (GO:0003044)5.76652449
14endocrine process (GO:0050886)5.76652449
15regulation of triglyceride catabolic process (GO:0010896)5.57008939
16drug metabolic process (GO:0017144)5.42588503
17adhesion of symbiont to host cell (GO:0044650)5.41009213
18virion attachment to host cell (GO:0019062)5.41009213
19regulation of systemic arterial blood pressure (GO:0003073)5.15967841
20very-low-density lipoprotein particle assembly (GO:0034379)5.02508933
21regulation of cGMP biosynthetic process (GO:0030826)4.92933850
22peptide hormone processing (GO:0016486)4.92234149
23cellular glucuronidation (GO:0052695)4.90930733
24glucuronate metabolic process (GO:0019585)4.82947959
25uronic acid metabolic process (GO:0006063)4.82947959
26diacylglycerol metabolic process (GO:0046339)4.77474112
27bile acid and bile salt transport (GO:0015721)4.77009767
28receptor guanylyl cyclase signaling pathway (GO:0007168)4.65790090
29digestion (GO:0007586)4.62246951
30adhesion of symbiont to host (GO:0044406)4.60920936
31plasma lipoprotein particle assembly (GO:0034377)4.54176879
32peptide catabolic process (GO:0043171)4.52178310
33vitamin A metabolic process (GO:0006776)4.51795324
34urea cycle (GO:0000050)4.46763699
35regulation of cellular extravasation (GO:0002691)4.46627103
36renal system process involved in regulation of blood volume (GO:0001977)4.42147479
37cellular response to nitric oxide (GO:0071732)4.38458578
38glycolipid catabolic process (GO:0019377)4.38134934
39glycosphingolipid catabolic process (GO:0046479)4.31553970
40drinking behavior (GO:0042756)4.30464661
41urea metabolic process (GO:0019627)4.29211094
42fat-soluble vitamin metabolic process (GO:0006775)4.21915239
43homocysteine metabolic process (GO:0050667)4.18503301
44flavonoid metabolic process (GO:0009812)4.15521000
45regulation of cGMP metabolic process (GO:0030823)4.13089280
46protein-lipid complex assembly (GO:0065005)4.11429905
47vitamin transmembrane transport (GO:0035461)4.09740526
48vitamin transport (GO:0051180)4.06793982
49regulation of vitamin metabolic process (GO:0030656)4.02737226
50alkaloid metabolic process (GO:0009820)4.01711337
51lipoprotein metabolic process (GO:0042157)4.00520660
52nitrogen cycle metabolic process (GO:0071941)3.95062009
53drug catabolic process (GO:0042737)3.89805805
54phospholipid efflux (GO:0033700)3.78200999
55cGMP biosynthetic process (GO:0006182)3.76440984
56vitamin biosynthetic process (GO:0009110)3.73887937
57positive regulation of cGMP biosynthetic process (GO:0030828)3.73821745
58exogenous drug catabolic process (GO:0042738)3.69710289
59regulation of cholesterol esterification (GO:0010872)3.68187074
60cellular response to reactive nitrogen species (GO:1902170)3.63411660
61vitamin D metabolic process (GO:0042359)3.62782883
62response to nitric oxide (GO:0071731)3.62449655
63mRNA modification (GO:0016556)3.60532602
64glutamine family amino acid biosynthetic process (GO:0009084)3.56164391
65positive regulation of triglyceride lipase activity (GO:0061365)3.55475026
66positive regulation of lipoprotein lipase activity (GO:0051006)3.55475026
67fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.54644279
68bile acid metabolic process (GO:0008206)3.52108455
69cobalamin metabolic process (GO:0009235)3.51736192
70ceramide catabolic process (GO:0046514)3.48813344
71positive regulation of glycoprotein biosynthetic process (GO:0010560)3.45678778
72sphingomyelin metabolic process (GO:0006684)3.42778996
73glycosylceramide metabolic process (GO:0006677)3.41962881
74sulfate transmembrane transport (GO:1902358)3.39025697
75antibacterial humoral response (GO:0019731)3.38002811
76maintenance of gastrointestinal epithelium (GO:0030277)3.35091853
77drug transport (GO:0015893)3.33635001
78glycerol metabolic process (GO:0006071)3.33156639
79positive regulation of lipid catabolic process (GO:0050996)3.33024480
80sphingolipid catabolic process (GO:0030149)3.31680900
81midgut development (GO:0007494)3.30445194
82positive regulation of cGMP metabolic process (GO:0030825)3.28055471
83antimicrobial humoral response (GO:0019730)3.27948435
84heme transport (GO:0015886)3.26354510
85cytidine deamination (GO:0009972)3.25818456
86cytidine metabolic process (GO:0046087)3.25818456
87cytidine catabolic process (GO:0006216)3.25818456
88urate metabolic process (GO:0046415)3.25212343
89quinone biosynthetic process (GO:1901663)3.21473370
90L-ascorbic acid metabolic process (GO:0019852)3.21247120
91phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.20933343
92nucleoside diphosphate biosynthetic process (GO:0009133)3.19962440
93membrane lipid catabolic process (GO:0046466)3.19214211
94omega-hydroxylase P450 pathway (GO:0097267)3.17899757
95phenol-containing compound catabolic process (GO:0019336)3.16602072
96sulfur compound transport (GO:0072348)3.14775596
97cholesterol homeostasis (GO:0042632)3.14589767
98drug transmembrane transport (GO:0006855)3.14245430
99digestive system process (GO:0022600)3.12694823
100angiotensin maturation (GO:0002003)12.3249774

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1CDX2_20551321_ChIP-Seq_CACO-2_Human5.49560562
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse4.22929493
3IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.98231116
4HNF4A_19761587_ChIP-ChIP_CACO-2_Human3.65352486
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.25307637
6GATA4_25053715_ChIP-Seq_YYC3_Human3.06090490
7GATA1_22025678_ChIP-Seq_K562_Human2.98129148
8SOX2_27498859_Chip-Seq_STOMACH_Mouse2.94506117
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.68235736
10LXR_22158963_ChIP-Seq_LIVER_Mouse2.56195910
11GATA6_25053715_ChIP-Seq_YYC3_Human2.55053529
12EGR1_23403033_ChIP-Seq_LIVER_Mouse2.49586976
13PPARA_22158963_ChIP-Seq_LIVER_Mouse2.46670673
14CDX2_19796622_ChIP-Seq_MESCs_Mouse2.46262263
15TRIM28_21343339_ChIP-Seq_HEK293_Human2.44293419
16PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.42477863
17CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.31148653
18SOX2_20726797_ChIP-Seq_SW620_Human2.22579162
19BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human2.05267125
20IRF8_22096565_ChIP-ChIP_GC-B_Human2.04027968
21NR0B1_18358816_ChIP-ChIP_MESCs_Mouse2.02772632
22STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.80266108
23FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.74712546
24AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.74216866
25PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.72734048
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.70683244
27PPAR_26484153_Chip-Seq_NCI-H1993_Human1.66223823
28FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.66024066
29RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.64097739
30FOXO3_23340844_ChIP-Seq_DLD1_Human1.62997557
31CLOCK_20551151_ChIP-Seq_293T_Human1.56158987
32TCF4_18268006_ChIP-ChIP_LS174T_Human1.47906123
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.47340971
34HNF4A_19822575_ChIP-Seq_HepG2_Human1.45981397
35LXR_22292898_ChIP-Seq_THP-1_Human1.42638655
36* CDX2_22108803_ChIP-Seq_LS180_Human1.33114511
37IRF8_21731497_ChIP-ChIP_J774_Mouse1.28837031
38FOXA1_25552417_ChIP-Seq_VCAP_Human1.27381621
39KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.27112469
40GATA2_19941826_ChIP-Seq_K562_Human1.24576603
41BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.23761418
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21676924
43ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20781575
44AR_21909140_ChIP-Seq_LNCAP_Human1.16308247
45TP63_17297297_ChIP-ChIP_HaCaT_Human1.11935570
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.10428915
47FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.09197594
48SA1_27219007_Chip-Seq_Bcells_Human1.07864424
49GATA1_19941826_ChIP-Seq_K562_Human1.07588805
50ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.07406931
51VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.06369767
52JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.04812633
53FOXA2_19822575_ChIP-Seq_HepG2_Human1.04545480
54KLF5_25053715_ChIP-Seq_YYC3_Human1.04526316
55BCOR_27268052_Chip-Seq_Bcells_Human1.04497035
56SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.03316328
57TCF3_18692474_ChIP-Seq_MEFs_Mouse1.03051703
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.02826575
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.02116774
60RACK7_27058665_Chip-Seq_MCF-7_Human1.02076249
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99500867
62EGR1_19032775_ChIP-ChIP_M12_Human0.99458038
63VDR_24787735_ChIP-Seq_THP-1_Human0.99011462
64TET1_21451524_ChIP-Seq_MESCs_Mouse0.96637842
65TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.95388842
66SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.94798883
67P63_26484246_Chip-Seq_KERATINOCYTES_Human0.93986675
68CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93925096
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.93676116
70GATA2_22383799_ChIP-Seq_G1ME_Mouse0.93100734
71* NANOG_20526341_ChIP-Seq_ESCs_Human0.92184865
72IKZF1_21737484_ChIP-ChIP_HCT116_Human0.91719023
73* BCL6_27268052_Chip-Seq_Bcells_Human0.91532802
74THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.90554375
75CEBPB_22108803_ChIP-Seq_LS180_Human0.90252303
76CTCF_27219007_Chip-Seq_Bcells_Human0.90221783
77CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.87988505
78SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87453231
79PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.86892467
80* RXR_22108803_ChIP-Seq_LS180_Human0.85996651
81KAP1_22055183_ChIP-Seq_ESCs_Mouse0.84561148
82PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.83792712
83SOX2_22085726_ChIP-Seq_NPCs_Mouse0.83789407
84SRY_22984422_ChIP-ChIP_TESTIS_Rat0.83475245
85FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.81015303
86FOXA1_21572438_ChIP-Seq_LNCaP_Human0.79138163
87SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.78875464
88GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.78151332
89DNAJC2_21179169_ChIP-ChIP_NT2_Human0.77456906
90STAT1_20625510_ChIP-Seq_HELA_Human0.76933666
91TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76812974
92* TP63_23658742_ChIP-Seq_EP156T_Human0.76721075
93RAD21_21589869_ChIP-Seq_MESCs_Mouse0.76529224
94Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.76521903
95ZNF263_19887448_ChIP-Seq_K562_Human0.76159341
96GATA3_24758297_ChIP-Seq_MCF-7_Human0.75407455
97TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.75362564
98GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.74504356
99ESR1_21235772_ChIP-Seq_MCF-7_Human0.74308292
100NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.74229872

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis9.90165291
2MP0001666_abnormal_nutrient_absorption5.03605850
3MP0005085_abnormal_gallbladder_physiolo5.00569341
4MP0003183_abnormal_peptide_metabolism4.92754054
5MP0004019_abnormal_vitamin_homeostasis4.00615811
6MP0004147_increased_porphyrin_level3.98163098
7MP0005365_abnormal_bile_salt3.96593109
8MP0009840_abnormal_foam_cell3.83116952
9MP0009379_abnormal_foot_pigmentation3.51558007
10MP0004264_abnormal_extraembryonic_tissu3.50185992
11MP0002139_abnormal_hepatobiliary_system3.46776603
12MP0010155_abnormal_intestine_physiology2.40933246
13MP0010234_abnormal_vibrissa_follicle2.32199372
14MP0010329_abnormal_lipoprotein_level2.30719423
15MP0005409_darkened_coat_color2.11582235
16MP0005332_abnormal_amino_acid1.99235416
17MP0003868_abnormal_feces_composition1.98793188
18MP0001664_abnormal_digestion1.94066814
19MP0009643_abnormal_urine_homeostasis1.92066969
20MP0003866_abnormal_defecation1.74095303
21MP0000538_abnormal_urinary_bladder1.69478957
22MP0000490_abnormal_crypts_of1.67044342
23MP0005670_abnormal_white_adipose1.62718593
24MP0003252_abnormal_bile_duct1.59430862
25MP0001764_abnormal_homeostasis1.56950930
26MP0003718_maternal_effect1.50342699
27MP0001765_abnormal_ion_homeostasis1.47698245
28MP0001188_hyperpigmentation1.46411325
29MP0003806_abnormal_nucleotide_metabolis1.43254680
30MP0005636_abnormal_mineral_homeostasis1.42201941
31MP0010352_gastrointestinal_tract_polyps1.37393724
32MP0000678_abnormal_parathyroid_gland1.35020169
33MP0004270_analgesia1.28785169
34MP0000477_abnormal_intestine_morphology1.26269173
35MP0005166_decreased_susceptibility_to1.25111190
36MP0002136_abnormal_kidney_physiology1.24506515
37MP0002118_abnormal_lipid_homeostasis1.23553155
38MP0003879_abnormal_hair_cell1.22738366
39MP0002822_catalepsy1.18737132
40MP0001501_abnormal_sleep_pattern1.13953046
41MP0000462_abnormal_digestive_system1.11925373
42MP0005448_abnormal_energy_balance1.11843075
43MP0005535_abnormal_body_temperature1.08887885
44MP0002876_abnormal_thyroid_physiology0.99806973
45MP0000609_abnormal_liver_physiology0.99221893
46MP0002971_abnormal_brown_adipose0.99080945
47MP0002396_abnormal_hematopoietic_system0.98038529
48MP0005584_abnormal_enzyme/coenzyme_acti0.92618313
49MP0004043_abnormal_pH_regulation0.89199657
50MP0000230_abnormal_systemic_arterial0.88051518
51MP0001873_stomach_inflammation0.86309277
52MP0001663_abnormal_digestive_system0.85032617
53MP0001756_abnormal_urination0.82058710
54MP0009115_abnormal_fat_cell0.79692294
55MP0005451_abnormal_body_composition0.75549420
56MP0005319_abnormal_enzyme/_coenzyme0.73448865
57MP0005381_digestive/alimentary_phenotyp0.73093717
58MP0009642_abnormal_blood_homeostasis0.72229259
59MP0001845_abnormal_inflammatory_respons0.72071774
60MP0002098_abnormal_vibrissa_morphology0.70710658
61MP0004782_abnormal_surfactant_physiolog0.70583398
62MP0008469_abnormal_protein_level0.68240796
63MP0008875_abnormal_xenobiotic_pharmacok0.67290373
64MP0004858_abnormal_nervous_system0.65729168
65MP0002796_impaired_skin_barrier0.65173048
66MP0000537_abnormal_urethra_morphology0.64143915
67MP0005666_abnormal_adipose_tissue0.62763165
68MP0008872_abnormal_physiological_respon0.61554379
69MP0006138_congestive_heart_failure0.60337375
70MP0003191_abnormal_cellular_cholesterol0.59662132
71MP0001485_abnormal_pinna_reflex0.59316278
72MP0005334_abnormal_fat_pad0.58191105
73MP0005501_abnormal_skin_physiology0.56919207
74MP0005174_abnormal_tail_pigmentation0.56104628
75MP0009785_altered_susceptibility_to0.56005227
76MP0000249_abnormal_blood_vessel0.54108579
77MP0002078_abnormal_glucose_homeostasis0.51979395
78MP0009764_decreased_sensitivity_to0.50623373
79MP0003953_abnormal_hormone_level0.50219278
80MP0008260_abnormal_autophagy0.49105255
81MP0000015_abnormal_ear_pigmentation0.48544475
82MP0003638_abnormal_response/metabolism_0.46991204
83MP0003300_gastrointestinal_ulcer0.45800859
84MP0002166_altered_tumor_susceptibility0.42396072
85MP0009697_abnormal_copulation0.42132335
86MP0000465_gastrointestinal_hemorrhage0.42059861
87MP0005376_homeostasis/metabolism_phenot0.41763312
88MP0006082_CNS_inflammation0.40679807
89MP0002896_abnormal_bone_mineralization0.39730771
90MP0005395_other_phenotype0.39351018
91MP0002069_abnormal_eating/drinking_beha0.38286089
92MP0001881_abnormal_mammary_gland0.37940388
93MP0003724_increased_susceptibility_to0.37258221
94MP0000604_amyloidosis0.35964654
95MP0000566_synostosis0.35793560
96MP0009333_abnormal_splenocyte_physiolog0.35628293
97MP0000013_abnormal_adipose_tissue0.35156246
98MP0002135_abnormal_kidney_morphology0.34176632
99MP0005025_abnormal_response_to0.34072119
100MP0000516_abnormal_urinary_system0.34053861

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of proline metabolism (HP:0010907)8.04715321
2Hydroxyprolinuria (HP:0003080)8.04715321
3Malnutrition (HP:0004395)7.30252304
4Hypobetalipoproteinemia (HP:0003563)6.46793609
5Abnormality of the vitamin B12 metabolism (HP:0004341)5.93779475
6Chronic diarrhea (HP:0002028)5.62475213
7Abnormality of vitamin B metabolism (HP:0004340)5.56503054
8Acanthocytosis (HP:0001927)5.18432717
9Widely patent fontanelles and sutures (HP:0004492)5.18174596
10Confusion (HP:0001289)5.16871687
11Fat malabsorption (HP:0002630)5.05877189
12Ileus (HP:0002595)4.93115465
13Hyperglycinuria (HP:0003108)4.56385491
14Abnormality of vitamin metabolism (HP:0100508)4.38446048
15Pigmentary retinal degeneration (HP:0001146)4.10976835
16Nausea (HP:0002018)3.97048871
17Glycosuria (HP:0003076)3.87715229
18Abnormality of urine glucose concentration (HP:0011016)3.87715229
19Thin bony cortex (HP:0002753)3.85259018
20Wide cranial sutures (HP:0010537)3.80381540
21Abnormality of serine family amino acid metabolism (HP:0010894)3.79621667
22Abnormality of glycine metabolism (HP:0010895)3.79621667
23Proximal tubulopathy (HP:0000114)3.67046072
24Nephrolithiasis (HP:0000787)3.53628864
25Megaloblastic anemia (HP:0001889)3.47934360
26Steatorrhea (HP:0002570)3.33465169
27Xanthomatosis (HP:0000991)3.26701417
28Potter facies (HP:0002009)3.24869202
29Facial shape deformation (HP:0011334)3.24869202
30Increased purine levels (HP:0004368)3.24549262
31Hyperuricemia (HP:0002149)3.24549262
32Hypolipoproteinemia (HP:0010981)3.14890952
33Decreased circulating renin level (HP:0003351)3.14671539
34Abdominal distention (HP:0003270)3.11776207
35Systemic lupus erythematosus (HP:0002725)3.09206384
36Posterior subcapsular cataract (HP:0007787)3.06888528
37Hypophosphatemia (HP:0002148)3.03587154
38Abnormality of aspartate family amino acid metabolism (HP:0010899)2.98790826
39Enlarged epiphyses (HP:0010580)2.95840629
40Congenital sensorineural hearing impairment (HP:0008527)2.94341270
41Abnormal urine phosphate concentration (HP:0012599)2.91603552
42Hyperactive renin-angiotensin system (HP:0000841)2.89728247
43Abnormality of purine metabolism (HP:0004352)2.88844390
44Metabolic alkalosis (HP:0200114)2.88610288
45Alkalosis (HP:0001948)2.80064583
46Delayed epiphyseal ossification (HP:0002663)2.75752751
47Hyperammonemia (HP:0001987)2.67745768
48Hyperphosphaturia (HP:0003109)2.64623700
49Hyperparathyroidism (HP:0000843)2.61392123
50Abnormality of the costochondral junction (HP:0000919)2.60557100
51Abnormality of monocarboxylic acid metabolism (HP:0010996)2.54094068
52Abnormality of nucleobase metabolism (HP:0010932)2.46136849
53Focal segmental glomerulosclerosis (HP:0000097)2.43718651
54Abnormality of renin-angiotensin system (HP:0000847)2.41540362
55Villous atrophy (HP:0011473)2.39180042
56Abnormality of small intestinal villus morphology (HP:0011472)2.39180042
57Gout (HP:0001997)2.37691468
58Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.37552186
59Hypotension (HP:0002615)2.37268477
60Epidermoid cyst (HP:0200040)2.36714708
61Metabolic acidosis (HP:0001942)2.36294564
62Poikilocytosis (HP:0004447)2.31169523
63Subcapsular cataract (HP:0000523)2.25297528
64Abnormal glucose tolerance (HP:0001952)2.25053092
65Abnormality of sulfur amino acid metabolism (HP:0004339)2.24675159
66Protuberant abdomen (HP:0001538)2.21094017
67Eczematoid dermatitis (HP:0000976)2.18235988
68Abnormality of magnesium homeostasis (HP:0004921)2.10161064
69Renal tubular acidosis (HP:0001947)2.09154168
70Hyperphosphatemia (HP:0002905)2.03970645
71Abnormality of glutamine family amino acid metabolism (HP:0010902)11.2351153
72Right ventricular cardiomyopathy (HP:0011663)1.99951654
73Renal tubular dysfunction (HP:0000124)1.99488246
74Irritability (HP:0000737)1.98127048
75Cerebral palsy (HP:0100021)1.95241945
76Gingivitis (HP:0000230)1.92048638
77Hemorrhage of the eye (HP:0011885)1.90909373
78Gastrointestinal dysmotility (HP:0002579)1.87719477
79Abnormality of dicarboxylic acid metabolism (HP:0010995)1.86853917
80Dicarboxylic aciduria (HP:0003215)1.86853917
81Pancreatitis (HP:0001733)1.85503353
82Multiple lipomas (HP:0001012)1.84089474
83White forelock (HP:0002211)1.83889526
84Patchy hypopigmentation of hair (HP:0011365)1.83401385
85Hypophosphatemic rickets (HP:0004912)1.79404040
86Symptomatic seizures (HP:0011145)1.77827398
87Glomerulosclerosis (HP:0000096)1.76189486
88Metaphyseal irregularity (HP:0003025)1.75689845
89Growth hormone excess (HP:0000845)1.75480838
90Abnormal enzyme/coenzyme activity (HP:0012379)1.74996510
91Abnormality of alkaline phosphatase activity (HP:0004379)1.74729677
92Abnormal albumin level (HP:0012116)1.71005583
93Hypoalbuminemia (HP:0003073)1.71005583
94Hypocalcemia (HP:0002901)1.70226768
95Lethargy (HP:0001254)1.66396565
96Dehydration (HP:0001944)1.65532521
97Paresthesia (HP:0003401)1.64225454
98Macrocytic anemia (HP:0001972)1.61446446
99Segmental peripheral demyelination/remyelination (HP:0003481)1.60267512
100Peripheral demyelination (HP:0011096)1.59185852

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ACVR1B9.65880630
2ERN14.18789164
3MST1R3.97544528
4PRKG23.74703490
5MAP3K103.55387662
6RIPK13.31903867
7EPHA22.55695101
8STK392.15844321
9TESK21.88402092
10MAP3K21.86095054
11OXSR11.78828161
12AKT31.78203352
13TNIK1.76066282
14PDK21.70919387
15MST41.70554644
16MAP3K121.60524508
17PTK61.56400348
18EPHA41.56382910
19GRK61.43768802
20MET1.43311119
21FGFR41.33251763
22EPHB21.29443565
23TYK21.28977779
24DDR21.25979956
25EPHA31.22012785
26STK241.11906169
27MATK1.06379011
28PIM11.06113887
29MAP2K21.02366844
30RIPK41.02327486
31MAP4K11.00279176
32EPHB10.98200751
33MYLK0.97784828
34MAP3K10.96165032
35CASK0.92542505
36PRPF4B0.91564826
37ERBB20.87017540
38NLK0.86336960
39PDPK10.82578676
40FGFR30.77252983
41PRKACG0.77143534
42DYRK1B0.73147671
43PRKAA20.72616304
44TESK10.71600384
45MAP2K60.71121403
46PIK3CA0.70631036
47MAP3K110.68957189
48BMPR20.67571121
49PRKCA0.63236708
50MAPK110.62702449
51PRKCZ0.62083414
52PDK10.61550327
53LMTK20.60997441
54TAOK10.60929942
55CDC42BPA0.57803965
56YES10.52241438
57FER0.51848740
58KSR20.51280951
59PRKCD0.45934159
60MAP3K30.45327024
61IRAK10.45230834
62ITK0.44896599
63SRC0.43444810
64CAMK2D0.43248521
65PIK3CG0.42179088
66FYN0.41334929
67NEK60.39951600
68PTK20.39689549
69DAPK20.39485798
70TEC0.38988425
71CAMK2G0.37766967
72TBK10.37713642
73RET0.35269691
74ABL20.34917305
75PAK40.34585302
76GRK10.33828232
77CAMK2B0.33760918
78CDK190.32086072
79BTK0.31476623
80CDK60.30969679
81MELK0.30414590
82JAK20.30309481
83CSF1R0.29594794
84PDGFRA0.29344536
85JAK10.28770366
86CSK0.25102166
87PRKACA0.24726347
88SYK0.24288735
89MAP3K80.23369535
90BMX0.20997939
91CAMK2A0.20200431
92PRKCI0.17123888
93IKBKE0.15659752
94LYN0.15511101
95IGF1R0.15339824
96ICK0.15257077
97RPS6KA20.14619853
98PRKCQ0.14552761
99EEF2K0.14047807
100PRKG10.13847972

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin digestion and absorption_Homo sapiens_hsa049775.22930409
2Cyanoamino acid metabolism_Homo sapiens_hsa004605.05046077
3Fat digestion and absorption_Homo sapiens_hsa049754.43526780
4Renin-angiotensin system_Homo sapiens_hsa046144.38629863
5Protein digestion and absorption_Homo sapiens_hsa049742.82453175
6Mineral absorption_Homo sapiens_hsa049782.69812113
7Starch and sucrose metabolism_Homo sapiens_hsa005002.64875207
8Caffeine metabolism_Homo sapiens_hsa002322.56886355
9Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.52876941
10Pentose and glucuronate interconversions_Homo sapiens_hsa000402.36855962
11Histidine metabolism_Homo sapiens_hsa003402.35359414
12Carbohydrate digestion and absorption_Homo sapiens_hsa049732.25302293
13Galactose metabolism_Homo sapiens_hsa000522.19423283
14Drug metabolism - other enzymes_Homo sapiens_hsa009832.05855930
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.02458153
16Arginine biosynthesis_Homo sapiens_hsa002202.01982892
17Chemical carcinogenesis_Homo sapiens_hsa052042.01649576
18Linoleic acid metabolism_Homo sapiens_hsa005912.01218038
19Retinol metabolism_Homo sapiens_hsa008301.97253457
20Fructose and mannose metabolism_Homo sapiens_hsa000511.95894363
21Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.82530004
22PPAR signaling pathway_Homo sapiens_hsa033201.81372657
23Bile secretion_Homo sapiens_hsa049761.71740465
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.71643672
25alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.70219068
26Steroid hormone biosynthesis_Homo sapiens_hsa001401.55457820
27Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.46938119
28Maturity onset diabetes of the young_Homo sapiens_hsa049501.44440667
29Arachidonic acid metabolism_Homo sapiens_hsa005901.42189047
30Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.37044163
31Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.36964139
32Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.30324565
33Arginine and proline metabolism_Homo sapiens_hsa003301.26974527
34Glycerolipid metabolism_Homo sapiens_hsa005611.25167593
35Sulfur metabolism_Homo sapiens_hsa009201.22887261
36Tryptophan metabolism_Homo sapiens_hsa003801.16424212
37Fatty acid degradation_Homo sapiens_hsa000711.04240469
38Phenylalanine metabolism_Homo sapiens_hsa003601.01941740
392-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.01620922
40Ether lipid metabolism_Homo sapiens_hsa005650.96756186
41Sphingolipid metabolism_Homo sapiens_hsa006000.81992475
42Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.80128820
43Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.67322224
44Glutathione metabolism_Homo sapiens_hsa004800.64994056
45Asthma_Homo sapiens_hsa053100.63837137
46Folate biosynthesis_Homo sapiens_hsa007900.63711879
47Intestinal immune network for IgA production_Homo sapiens_hsa046720.63508339
48Glycerophospholipid metabolism_Homo sapiens_hsa005640.61056925
49Pancreatic secretion_Homo sapiens_hsa049720.51884126
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.50669100
51Fatty acid metabolism_Homo sapiens_hsa012120.50295103
52Pentose phosphate pathway_Homo sapiens_hsa000300.49252107
53Fatty acid biosynthesis_Homo sapiens_hsa000610.45766937
54Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45496413
55Peroxisome_Homo sapiens_hsa041460.45027361
56Allograft rejection_Homo sapiens_hsa053300.42899460
57Autoimmune thyroid disease_Homo sapiens_hsa053200.39054123
58Tyrosine metabolism_Homo sapiens_hsa003500.38440565
59ABC transporters_Homo sapiens_hsa020100.38388985
60Renin secretion_Homo sapiens_hsa049240.37275476
61Graft-versus-host disease_Homo sapiens_hsa053320.36352137
62Insulin resistance_Homo sapiens_hsa049310.35685633
63Adipocytokine signaling pathway_Homo sapiens_hsa049200.34389537
64Cocaine addiction_Homo sapiens_hsa050300.31148065
65Biosynthesis of amino acids_Homo sapiens_hsa012300.25583416
66Glucagon signaling pathway_Homo sapiens_hsa049220.25386433
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.25342405
68Type I diabetes mellitus_Homo sapiens_hsa049400.25284701
69Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.23059250
70Metabolic pathways_Homo sapiens_hsa011000.23027960
71Other glycan degradation_Homo sapiens_hsa005110.20706623
72Staphylococcus aureus infection_Homo sapiens_hsa051500.20348568
73Carbon metabolism_Homo sapiens_hsa012000.20149180
74Thyroid hormone synthesis_Homo sapiens_hsa049180.19820539
75Pyruvate metabolism_Homo sapiens_hsa006200.19674250
76Sulfur relay system_Homo sapiens_hsa041220.18168719
77Primary bile acid biosynthesis_Homo sapiens_hsa001200.17368948
78Serotonergic synapse_Homo sapiens_hsa047260.16434586
79Insulin secretion_Homo sapiens_hsa049110.16420125
80Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.15958968
81Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.15851776
82Amphetamine addiction_Homo sapiens_hsa050310.15547725
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.11608671
84Hepatitis C_Homo sapiens_hsa051600.07804709
85Antigen processing and presentation_Homo sapiens_hsa046120.07514579
86Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.07508555
87AMPK signaling pathway_Homo sapiens_hsa041520.07174953
88Fatty acid elongation_Homo sapiens_hsa000620.04612895
89Propanoate metabolism_Homo sapiens_hsa006400.03838398
90Tight junction_Homo sapiens_hsa045300.03401343
91Ovarian steroidogenesis_Homo sapiens_hsa049130.03348143
92GnRH signaling pathway_Homo sapiens_hsa049120.00168640
93Leishmaniasis_Homo sapiens_hsa051400.00018000
94Hematopoietic cell lineage_Homo sapiens_hsa04640-0.0249064
95Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280-0.0218946
96Gap junction_Homo sapiens_hsa04540-0.0199855
97Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040-0.0144446
98Leukocyte transendothelial migration_Homo sapiens_hsa04670-0.0051870
99Butanoate metabolism_Homo sapiens_hsa00650-0.0032694
100Aldosterone synthesis and secretion_Homo sapiens_hsa04925-0.0018551

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