CPOX

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is the sixth enzyme of the heme biosynthetic pathway. The encoded enzyme is soluble and found in the intermembrane space of mitochondria. This enzyme catalyzes the stepwise oxidative decarboxylation of coproporphyrinogen III to protoporphyrinogen IX, a precursor of heme. Defects in this gene are a cause of hereditary coproporphyria (HCP). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* protoporphyrinogen IX metabolic process (GO:0046501)8.33963701
2* protoporphyrinogen IX biosynthetic process (GO:0006782)7.31616404
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.21487597
4L-phenylalanine catabolic process (GO:0006559)7.21487597
5L-phenylalanine metabolic process (GO:0006558)6.77851241
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.77851241
7nuclear pore complex assembly (GO:0051292)6.25350440
8aromatic amino acid family catabolic process (GO:0009074)6.10947140
9mitotic chromosome condensation (GO:0007076)5.76143870
10cysteine metabolic process (GO:0006534)5.75506738
11DNA unwinding involved in DNA replication (GO:0006268)5.75359639
12* porphyrin-containing compound biosynthetic process (GO:0006779)5.74352563
13triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.38778835
14nuclear pore organization (GO:0006999)5.31184382
15* heme biosynthetic process (GO:0006783)5.28378641
16glyoxylate metabolic process (GO:0046487)5.26204394
17* porphyrin-containing compound metabolic process (GO:0006778)5.24253244
18* tetrapyrrole biosynthetic process (GO:0033014)5.19841107
19heme transport (GO:0015886)5.15213671
20very-low-density lipoprotein particle assembly (GO:0034379)5.14720131
21bile acid biosynthetic process (GO:0006699)5.14197777
22indole-containing compound catabolic process (GO:0042436)5.11471541
23indolalkylamine catabolic process (GO:0046218)5.11471541
24tryptophan catabolic process (GO:0006569)5.11471541
25alpha-linolenic acid metabolic process (GO:0036109)5.00704077
26kynurenine metabolic process (GO:0070189)5.00565435
27* heme metabolic process (GO:0042168)4.89642215
28negative regulation of fibrinolysis (GO:0051918)4.83429115
29lysine metabolic process (GO:0006553)4.79271272
30lysine catabolic process (GO:0006554)4.79271272
31tryptophan metabolic process (GO:0006568)4.79227880
32high-density lipoprotein particle remodeling (GO:0034375)4.72023089
33regulation of translational fidelity (GO:0006450)4.63906929
34plasma lipoprotein particle assembly (GO:0034377)4.63176004
35regulation of fibrinolysis (GO:0051917)4.61003930
36protein carboxylation (GO:0018214)4.60009944
37peptidyl-glutamic acid carboxylation (GO:0017187)4.60009944
38mitotic sister chromatid segregation (GO:0000070)4.53636224
39pore complex assembly (GO:0046931)4.46889751
40formation of translation preinitiation complex (GO:0001731)4.45907549
41urea cycle (GO:0000050)4.43291892
42urea metabolic process (GO:0019627)4.43291892
43bile acid metabolic process (GO:0008206)4.42507569
44regulation of protein activation cascade (GO:2000257)4.38818274
45sulfur amino acid catabolic process (GO:0000098)4.38200975
46fatty acid elongation (GO:0030497)4.36932836
47protein-lipid complex assembly (GO:0065005)4.35087354
48DNA topological change (GO:0006265)4.31846221
49aromatic amino acid family metabolic process (GO:0009072)4.31571262
50sister chromatid segregation (GO:0000819)4.30709712
51regulation of triglyceride catabolic process (GO:0010896)4.30651632
52serine family amino acid metabolic process (GO:0009069)4.28312289
53serine family amino acid biosynthetic process (GO:0009070)4.27039950
54regulation of sister chromatid cohesion (GO:0007063)4.26064544
55serine family amino acid catabolic process (GO:0009071)4.24266077
56glutamate metabolic process (GO:0006536)4.23487102
57hemoglobin metabolic process (GO:0020027)4.21317460
58cofactor catabolic process (GO:0051187)4.21107050
59nitrogen cycle metabolic process (GO:0071941)4.20241261
60complement activation, alternative pathway (GO:0006957)4.19626163
61glycine metabolic process (GO:0006544)4.15511814
62cholesterol efflux (GO:0033344)4.14935202
63proline biosynthetic process (GO:0006561)4.13738573
64fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.13661947
65* response to methylmercury (GO:0051597)4.12940889
66alpha-amino acid catabolic process (GO:1901606)4.12266410
67regulation of RNA export from nucleus (GO:0046831)4.11817167
68plasma lipoprotein particle clearance (GO:0034381)4.10573982
69amino-acid betaine metabolic process (GO:0006577)4.09424417
70mitotic sister chromatid cohesion (GO:0007064)4.08196882
71reverse cholesterol transport (GO:0043691)4.08106181
72regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.06338198
73aspartate family amino acid catabolic process (GO:0009068)4.05895658
74regulation of complement activation (GO:0030449)4.04970769
75ethanol oxidation (GO:0006069)4.04595661
76tyrosine metabolic process (GO:0006570)4.03831691
77regulation of cholesterol esterification (GO:0010872)4.03127870
78coenzyme catabolic process (GO:0009109)3.99512700
79protein localization to chromosome, centromeric region (GO:0071459)3.99203602
80plasma lipoprotein particle remodeling (GO:0034369)3.98251789
81protein-lipid complex remodeling (GO:0034368)3.98251789
82macromolecular complex remodeling (GO:0034367)3.98251789
83homocysteine metabolic process (GO:0050667)3.97305644
84negative regulation of cholesterol transport (GO:0032375)3.88246678
85negative regulation of sterol transport (GO:0032372)3.88246678
86cellular ketone body metabolic process (GO:0046950)3.86985353
87acylglycerol homeostasis (GO:0055090)3.86295675
88triglyceride homeostasis (GO:0070328)3.86295675
89phospholipid efflux (GO:0033700)3.83719897
90DNA replication initiation (GO:0006270)3.83691149
91positive regulation of lipoprotein lipase activity (GO:0051006)3.81398679
92positive regulation of triglyceride lipase activity (GO:0061365)3.81398679
93erythrocyte maturation (GO:0043249)3.78635232
94DNA strand elongation involved in DNA replication (GO:0006271)3.78394893
95cellular amino acid catabolic process (GO:0009063)3.78224677
96short-chain fatty acid metabolic process (GO:0046459)3.75984333
97amine catabolic process (GO:0009310)3.74671479
98cellular biogenic amine catabolic process (GO:0042402)3.74671479
99acetyl-CoA metabolic process (GO:0006084)3.73120698
100blood coagulation, intrinsic pathway (GO:0007597)3.70236502
101L-serine metabolic process (GO:0006563)3.69797042
102DNA strand elongation (GO:0022616)3.67966572
103mitotic nuclear envelope disassembly (GO:0007077)3.67749896
104imidazole-containing compound metabolic process (GO:0052803)3.66322815
105drug transmembrane transport (GO:0006855)3.65511991
106plasma lipoprotein particle organization (GO:0071827)3.65256082
107indolalkylamine metabolic process (GO:0006586)3.64510023
108iron coordination entity transport (GO:1901678)3.62600430
109response to nitrosative stress (GO:0051409)3.61250028
110establishment of integrated proviral latency (GO:0075713)3.61161428
111very long-chain fatty acid metabolic process (GO:0000038)3.57322178
112* tetrapyrrole metabolic process (GO:0033013)3.57192831
113protein-lipid complex subunit organization (GO:0071825)3.55263957
114response to mercury ion (GO:0046689)3.54776928
115mitotic metaphase plate congression (GO:0007080)3.54285789
116regulation of nucleobase-containing compound transport (GO:0032239)3.53173530
117bile acid and bile salt transport (GO:0015721)3.52920048
118chromosome condensation (GO:0030261)3.51916347
119membrane disassembly (GO:0030397)3.51320483
120nuclear envelope disassembly (GO:0051081)3.51320483
121dicarboxylic acid biosynthetic process (GO:0043650)3.51214014
122cellular modified amino acid catabolic process (GO:0042219)3.50551170
123regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.49546772
124cholesterol homeostasis (GO:0042632)3.48460930
125folic acid-containing compound biosynthetic process (GO:0009396)3.48324499
126cellular protein complex localization (GO:0034629)3.47869814
127COPI coating of Golgi vesicle (GO:0048205)3.46910970
128Golgi transport vesicle coating (GO:0048200)3.46910970
129telomere maintenance via semi-conservative replication (GO:0032201)3.44474661
130cellular glucuronidation (GO:0052695)3.43962861
131fibrinolysis (GO:0042730)3.43685401
132sterol homeostasis (GO:0055092)3.42549581
133arginine metabolic process (GO:0006525)3.41487590
134ribosome assembly (GO:0042255)3.39112682
135oxygen transport (GO:0015671)3.33906901
136regulation of mitotic spindle organization (GO:0060236)3.33518749
137protein localization to kinetochore (GO:0034501)3.31137700
138DNA duplex unwinding (GO:0032508)3.22895768
139nucleobase-containing small molecule interconversion (GO:0015949)3.21031035
140positive regulation of chromosome segregation (GO:0051984)3.18594627
141protein export from nucleus (GO:0006611)3.16562400
142gas transport (GO:0015669)3.15599217
143positive regulation of DNA-dependent DNA replication (GO:2000105)3.15245361
144regulation of translational termination (GO:0006449)3.13707492
145protein complex localization (GO:0031503)3.11431168
146DNA conformation change (GO:0071103)3.10570449
147DNA geometric change (GO:0032392)3.08394129
148erythrocyte development (GO:0048821)3.02763446
149DNA synthesis involved in DNA repair (GO:0000731)3.02375757
150iron ion import (GO:0097286)3.02206730
151regulation of chromosome segregation (GO:0051983)3.01778010
152mRNA stabilization (GO:0048255)2.99051503
153RNA stabilization (GO:0043489)2.99051503
154telomere maintenance via recombination (GO:0000722)2.97533309
155chromatin assembly (GO:0031497)2.96996967
156deoxyribonucleotide biosynthetic process (GO:0009263)2.96937466
157DNA packaging (GO:0006323)2.95970591
158ribosomal large subunit biogenesis (GO:0042273)2.95712581
159peptidyl-threonine dephosphorylation (GO:0035970)2.95065067
160regulation of spindle organization (GO:0090224)2.90919958
161mitotic recombination (GO:0006312)2.88973696
162establishment of viral latency (GO:0019043)2.88715639
163ribosomal small subunit biogenesis (GO:0042274)2.88348997
164maturation of SSU-rRNA (GO:0030490)2.86007754
165nuclear envelope organization (GO:0006998)2.84556883
166positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.80100333
167positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.80100333
168positive regulation of mitotic sister chromatid separation (GO:1901970)2.80100333
169negative regulation of erythrocyte differentiation (GO:0045647)2.79903062
170DNA replication checkpoint (GO:0000076)2.79366937
171heterochromatin organization (GO:0070828)2.79311058
172chromosome segregation (GO:0007059)2.77189857
173regulation of translational elongation (GO:0006448)2.75237354
174ribonucleoprotein complex biogenesis (GO:0022613)2.71182623
175establishment of chromosome localization (GO:0051303)2.70617032
176metaphase plate congression (GO:0051310)2.69545947
177tRNA aminoacylation for protein translation (GO:0006418)2.67504771
178negative regulation of DNA repair (GO:0045738)2.65843112
179ribosome biogenesis (GO:0042254)2.64912291
180mitochondrial fusion (GO:0008053)2.63020630
181negative regulation of potassium ion transmembrane transport (GO:1901380)2.62934497
182regulation of histone H3-K9 methylation (GO:0051570)2.62238867
183protein localization to chromosome (GO:0034502)2.59343099
184meiotic chromosome segregation (GO:0045132)2.58631516
185proline metabolic process (GO:0006560)2.58207457
186regulation of protein export from nucleus (GO:0046825)2.56992525
187tetrahydrofolate metabolic process (GO:0046653)2.54843482
188tRNA aminoacylation (GO:0043039)2.54114353
189amino acid activation (GO:0043038)2.54114353
190negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.53817878
191innate immune response in mucosa (GO:0002227)2.53309119
192embryonic process involved in female pregnancy (GO:0060136)2.52878201
193G1 DNA damage checkpoint (GO:0044783)2.52103530

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.17698281
2EGR1_23403033_ChIP-Seq_LIVER_Mouse6.60324411
3PPARA_22158963_ChIP-Seq_LIVER_Mouse6.23528210
4* LXR_22158963_ChIP-Seq_LIVER_Mouse5.56060006
5CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.59562486
6GATA1_22025678_ChIP-Seq_K562_Human4.48301246
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.40014387
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.84123458
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.63457508
10PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.60459766
11EGR1_19374776_ChIP-ChIP_THP-1_Human3.53181122
12MYC_18555785_ChIP-Seq_MESCs_Mouse3.37799323
13* GATA1_19941826_ChIP-Seq_K562_Human3.25615442
14* NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.24521490
15E2F4_17652178_ChIP-ChIP_JURKAT_Human3.22791210
16FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.06274634
17GATA1_19941827_ChIP-Seq_MEL_Mouse2.66489002
18* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse2.62068977
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.55404721
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.47296749
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.44173988
22MYC_22102868_ChIP-Seq_BL_Human2.38223284
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.37843140
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.36698133
25KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse2.31868791
26TP63_17297297_ChIP-ChIP_HaCaT_Human2.26051240
27MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16091665
28E2F1_21310950_ChIP-Seq_MCF-7_Human2.15778598
29NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15513906
30MYC_18358816_ChIP-ChIP_MESCs_Mouse2.04674244
31ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.6747614
32ZFX_18555785_ChIP-Seq_MESCs_Mouse1.99321300
33KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.97270876
34* GATA2_19941826_ChIP-Seq_K562_Human1.89834131
35* DCP1A_22483619_ChIP-Seq_HELA_Human1.89545899
36MYCN_18555785_ChIP-Seq_MESCs_Mouse1.89401657
37POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.87975485
38RBPJ_22232070_ChIP-Seq_NCS_Mouse1.86049707
39SCL_19346495_ChIP-Seq_HPC-7_Human1.81021139
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.80869282
41XRN2_22483619_ChIP-Seq_HELA_Human1.78791822
42HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.70970320
43CREB1_15753290_ChIP-ChIP_HEK293T_Human1.69855388
44GATA1_22383799_ChIP-Seq_G1ME_Mouse1.65467717
45CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.62274293
46KLF4_18555785_ChIP-Seq_MESCs_Mouse1.62088449
47ZNF263_19887448_ChIP-Seq_K562_Human1.61536007
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.60654704
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.58466126
50DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.57065124
51* FOXA2_19822575_ChIP-Seq_HepG2_Human1.56432620
52TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56323204
53* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.49115132
54CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.44032365
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.43596828
56TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.42561070
57TTF2_22483619_ChIP-Seq_HELA_Human1.38831327
58CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.36967294
59SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36873283
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35550521
61CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.35276556
62TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.34831109
63MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.34187646
64TFEB_21752829_ChIP-Seq_HELA_Human1.33676554
65CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33463037
66* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.30842790
67HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.30747659
68SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.30695143
69VDR_21846776_ChIP-Seq_THP-1_Human1.30214621
70ATF3_27146783_Chip-Seq_COLON_Human1.26846375
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.25364413
72THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.25151111
73PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25123014
74HNF4A_19822575_ChIP-Seq_HepG2_Human1.22431323
75HTT_18923047_ChIP-ChIP_STHdh_Human1.22154550
76SOX2_27498859_Chip-Seq_STOMACH_Mouse1.21226609
77KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.20534734
78HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20506483
79CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14629254
80ETS1_20019798_ChIP-Seq_JURKAT_Human1.14604387
81ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.12496660
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11470404
83KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11224055
84TCF7_22412390_ChIP-Seq_EML_Mouse1.11220194
85JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10855660
86SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10235473
87SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.10103089
88FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.09461916
89MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09047589
90CHD1_26751641_Chip-Seq_LNCaP_Human1.08835874
91PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.08436236
92FOXM1_23109430_ChIP-Seq_U2OS_Human1.07725476
93KDM5A_27292631_Chip-Seq_BREAST_Human1.06340070
94AR_21909140_ChIP-Seq_LNCAP_Human1.03204351
95NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02516320
96E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.02179994
97GABP_19822575_ChIP-Seq_HepG2_Human1.01689286
98PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.00701390
99KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00613885
100TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99944814
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.99337807
102KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98791462
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.98468215
104CLOCK_20551151_ChIP-Seq_293T_Human0.97476450
105FOXP3_21729870_ChIP-Seq_TREG_Human0.96963819
106ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96418717
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.95270212
108ELK3_25401928_ChIP-Seq_HUVEC_Human0.92981460
109ESR1_15608294_ChIP-ChIP_MCF-7_Human0.91948199
110VDR_23849224_ChIP-Seq_CD4+_Human0.91759177
111BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91489628
112EST1_17652178_ChIP-ChIP_JURKAT_Human0.90654856
113GATA4_25053715_ChIP-Seq_YYC3_Human0.89301651
114MAF_26560356_Chip-Seq_TH1_Human0.89031034
115STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.87369198
116TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.85332812
117POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.84789858
118ELK1_19687146_ChIP-ChIP_HELA_Human0.83940018
119SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83914042
120AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.83870115
121SOX17_20123909_ChIP-Seq_XEN_Mouse0.83830420
122PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.80763891
123GATA6_25053715_ChIP-Seq_YYC3_Human0.80415808
124AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79710052
125TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78732775
126RXRA_24833708_ChIP-Seq_LIVER_Mouse0.76673650
127* FOXA1_25552417_ChIP-Seq_VCAP_Human0.72792903
128E2F7_22180533_ChIP-Seq_HELA_Human0.71771739
129GATA2_22383799_ChIP-Seq_G1ME_Mouse0.70730401
130* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.67522300
131* SALL4_18804426_ChIP-ChIP_XEN_Mouse0.67239446
132* FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.64313969
133* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.64070007
134GATA1_19941827_ChIP-Seq_MEL86_Mouse0.63581810
135LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.62345450
136FOXO3_23340844_ChIP-Seq_DLD1_Human0.62171825
137CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.61119612
138* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.60753839
139IRF1_19129219_ChIP-ChIP_H3396_Human0.59758269
140BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.59648468
141SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.59185275
142NCOR1_26117541_ChIP-Seq_K562_Human0.59083493
143FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.58071722
144ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.57348976
145MYC_19915707_ChIP-ChIP_AK7_Human0.56981254
146ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.56081430
147MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.55330605
148SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.54298233
149GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.54222268
150* GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.54108701
151RARA_24833708_ChIP-Seq_LIVER_Mouse0.53427333
152BRD4_27068464_Chip-Seq_AML-cells_Mouse0.52449157
153GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.52361946
154BCOR_27268052_Chip-Seq_Bcells_Human0.52080173
155PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.51327479
156CEBPB_22108803_ChIP-Seq_LS180_Human0.50188857
157EOMES_21245162_ChIP-Seq_HESCs_Human0.49326717
158STAT3_1855785_ChIP-Seq_MESCs_Mouse0.48410081
159NANOG_20526341_ChIP-Seq_ESCs_Human0.48225761
160OCT4_20526341_ChIP-Seq_ESCs_Human0.47528737
161CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.47180388
162ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.46954676
163CTCF_27219007_Chip-Seq_ERYTHROID_Human0.45693171
164P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.45112653
165EGR1_19032775_ChIP-ChIP_M12_Human0.43550227
166SALL4_22934838_ChIP-ChIP_CD34+_Human0.43340080
167NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.43171638
168P53_21459846_ChIP-Seq_SAOS-2_Human0.43138217
169VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.42302960
170KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.42276412
171HNFA_21074721_ChIP-Seq_CACO-2_Human0.41787777
172NCOR_22424771_ChIP-Seq_293T_Human0.41655473
173TAF2_19829295_ChIP-Seq_ESCs_Human0.41556760
174PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.41342140
175RAD21_21589869_ChIP-Seq_MESCs_Mouse0.40285821
176CTCF_20526341_ChIP-Seq_ESCs_Human0.39780236
177EBNA1_20929547_Chip-Seq_RAJI-cells_Human0.39438201

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.45522312
2MP0003656_abnormal_erythrocyte_physiolo6.38226194
3MP0005360_urolithiasis6.35992566
4MP0005085_abnormal_gallbladder_physiolo5.59484658
5MP0004147_increased_porphyrin_level5.12502260
6MP0005365_abnormal_bile_salt4.87787888
7MP0003806_abnormal_nucleotide_metabolis4.78799546
8MP0005083_abnormal_biliary_tract4.39545387
9MP0008875_abnormal_xenobiotic_pharmacok4.24766779
10MP0010234_abnormal_vibrissa_follicle3.75124870
11MP0004957_abnormal_blastocyst_morpholog3.49723653
12MP0010094_abnormal_chromosome_stability3.49399678
13MP0002877_abnormal_melanocyte_morpholog3.36024436
14MP0008057_abnormal_DNA_replication3.33766590
15MP0003693_abnormal_embryo_hatching3.25007853
16MP0003252_abnormal_bile_duct3.23505997
17MP0009840_abnormal_foam_cell2.96987412
18MP0003077_abnormal_cell_cycle2.85519614
19MP0010352_gastrointestinal_tract_polyps2.83876556
20MP0010329_abnormal_lipoprotein_level2.80678906
21MP0003195_calcinosis2.70853488
22MP0001666_abnormal_nutrient_absorption2.43551931
23MP0005332_abnormal_amino_acid2.36222142
24MP0001730_embryonic_growth_arrest2.12622604
25MP0005076_abnormal_cell_differentiation2.05762264
26MP0000350_abnormal_cell_proliferation1.97904930
27MP0000609_abnormal_liver_physiology1.96859460
28MP0002118_abnormal_lipid_homeostasis1.93138986
29MP0004808_abnormal_hematopoietic_stem1.92756868
30MP0002396_abnormal_hematopoietic_system1.81969887
31MP0003868_abnormal_feces_composition1.77560456
32MP0008058_abnormal_DNA_repair1.72888614
33MP0003191_abnormal_cellular_cholesterol1.71389242
34MP0002009_preneoplasia1.71384631
35MP0005636_abnormal_mineral_homeostasis1.71117166
36MP0002138_abnormal_hepatobiliary_system1.68952955
37MP0008932_abnormal_embryonic_tissue1.62118282
38MP0010307_abnormal_tumor_latency1.61624978
39MP0005380_embryogenesis_phenotype1.56629303
40MP0001672_abnormal_embryogenesis/_devel1.56629303
41MP0001697_abnormal_embryo_size1.55580315
42MP0005451_abnormal_body_composition1.53639384
43MP0005584_abnormal_enzyme/coenzyme_acti1.51413305
44MP0002080_prenatal_lethality1.49824971
45MP0003984_embryonic_growth_retardation1.49444247
46MP0005319_abnormal_enzyme/_coenzyme1.48859377
47MP0002086_abnormal_extraembryonic_tissu1.47730014
48MP0003186_abnormal_redox_activity1.47677113
49MP0000920_abnormal_myelination1.46262050
50MP0000313_abnormal_cell_death1.45590660
51MP0004019_abnormal_vitamin_homeostasis1.43672133
52MP0008007_abnormal_cellular_replicative1.41923835
53MP0002088_abnormal_embryonic_growth/wei1.40638398
54MP0002006_tumorigenesis1.38199952
55MP0003566_abnormal_cell_adhesion1.34451708
56MP0002166_altered_tumor_susceptibility1.31283198
57MP0006036_abnormal_mitochondrial_physio1.28300273
58MP0001764_abnormal_homeostasis1.27503679
59MP0001348_abnormal_lacrimal_gland1.25288139
60MP0003690_abnormal_glial_cell1.24370095
61MP0009643_abnormal_urine_homeostasis1.24058526
62MP0001727_abnormal_embryo_implantation1.19390310
63MP0003329_amyloid_beta_deposits1.18063422
64MP0003221_abnormal_cardiomyocyte_apopto1.13112029
65MP0000598_abnormal_liver_morphology1.10024286
66MP0005257_abnormal_intraocular_pressure1.09419651
67MP0000604_amyloidosis1.09313749
68MP0008961_abnormal_basal_metabolism1.09142542
69MP0000490_abnormal_crypts_of1.08879742
70MP0004264_abnormal_extraembryonic_tissu1.08681476
71MP0002084_abnormal_developmental_patter1.08223312
72MP0002019_abnormal_tumor_incidence1.07488066
73MP0005621_abnormal_cell_physiology1.06724158
74MP0009333_abnormal_splenocyte_physiolog1.05538262
75MP0002060_abnormal_skin_morphology1.04236499
76MP0009765_abnormal_xenobiotic_induced1.02635064
77MP0002398_abnormal_bone_marrow1.00063530
78MP0002085_abnormal_embryonic_tissue0.97984859
79MP0003011_delayed_dark_adaptation0.96309454
80MP0004197_abnormal_fetal_growth/weight/0.95164544
81MP0009763_increased_sensitivity_to0.94791531
82MP0003786_premature_aging0.94641520
83MP0001881_abnormal_mammary_gland0.94492579
84MP0003763_abnormal_thymus_physiology0.91963897
85MP0005384_cellular_phenotype0.91929058
86MP0004233_abnormal_muscle_weight0.91400526
87MP0005647_abnormal_sex_gland0.90986316
88MP0009697_abnormal_copulation0.90408952
89MP0009764_decreased_sensitivity_to0.90056333
90MP0000703_abnormal_thymus_morphology0.89770809
91MP0008872_abnormal_physiological_respon0.88208421
92MP0001986_abnormal_taste_sensitivity0.86327761
93MP0001216_abnormal_epidermal_layer0.85490394
94MP0000358_abnormal_cell_content/0.84816376
95MP0004043_abnormal_pH_regulation0.84179575
96MP0002722_abnormal_immune_system0.82370577
97MP0000858_altered_metastatic_potential0.81414639
98MP0001915_intracranial_hemorrhage0.81260220
99MP0001529_abnormal_vocalization0.80623506
100MP0005408_hypopigmentation0.79459868
101MP0003943_abnormal_hepatobiliary_system0.78859296
102MP0003890_abnormal_embryonic-extraembry0.74800058
103MP0000685_abnormal_immune_system0.73895206
104MP0002429_abnormal_blood_cell0.72379653
105MP0004272_abnormal_basement_membrane0.72340376
106MP0001873_stomach_inflammation0.72099965
107MP0004947_skin_inflammation0.71212265
108MP0005376_homeostasis/metabolism_phenot0.70037808
109MP0005375_adipose_tissue_phenotype0.69506699
110MP0009642_abnormal_blood_homeostasis0.68864928
111MP0001661_extended_life_span0.68742842
112MP0000689_abnormal_spleen_morphology0.68545236
113MP0008438_abnormal_cutaneous_collagen0.66007738
114MP0005266_abnormal_metabolism0.65964622
115MP0008260_abnormal_autophagy0.65295588
116MP0009379_abnormal_foot_pigmentation0.65087707
117MP0009278_abnormal_bone_marrow0.64391129
118MP0008469_abnormal_protein_level0.64078666
119MP0002092_abnormal_eye_morphology0.63886096
120MP0005501_abnormal_skin_physiology0.63676148
121MP0005464_abnormal_platelet_physiology0.62510490
122MP0004185_abnormal_adipocyte_glucose0.61451417
123MP0003950_abnormal_plasma_membrane0.61071926
124MP0003091_abnormal_cell_migration0.61022039
125MP0003941_abnormal_skin_development0.60672566
126MP0005334_abnormal_fat_pad0.60457495
127MP0003315_abnormal_perineum_morphology0.59241492
128MP0006035_abnormal_mitochondrial_morpho0.57910402
129MP0002078_abnormal_glucose_homeostasis0.57480545
130MP0004381_abnormal_hair_follicle0.56913246
131MP0002971_abnormal_brown_adipose0.56104626
132MP0002132_abnormal_respiratory_system0.55230486
133MP0005535_abnormal_body_temperature0.54789436
134MP0003705_abnormal_hypodermis_morpholog0.54666256
135MP0008873_increased_physiological_sensi0.51870722
136MP0009931_abnormal_skin_appearance0.50776000
137MP0002229_neurodegeneration0.49596020
138MP0003632_abnormal_nervous_system0.49236419
139MP0003718_maternal_effect0.48575904
140MP0000747_muscle_weakness0.47833736
141MP0005220_abnormal_exocrine_pancreas0.47239765
142MP0008775_abnormal_heart_ventricle0.46495879
143MP0004142_abnormal_muscle_tone0.46407477
144MP0009672_abnormal_birth_weight0.46219726
145MP0001756_abnormal_urination0.44402062
146MP0003300_gastrointestinal_ulcer0.44181811
147MP0004885_abnormal_endolymph0.42401349
148MP0000639_abnormal_adrenal_gland0.41933047
149MP0005666_abnormal_adipose_tissue0.41483994
150MP0008874_decreased_physiological_sensi0.39587516
151MP0002136_abnormal_kidney_physiology0.38930850
152MP0003631_nervous_system_phenotype0.37310070
153MP0003453_abnormal_keratinocyte_physiol0.37126985
154MP0004130_abnormal_muscle_cell0.36287225
155MP0000579_abnormal_nail_morphology0.35208208
156MP0005448_abnormal_energy_balance0.35016510
157MP0001765_abnormal_ion_homeostasis0.34588602
158MP0005084_abnormal_gallbladder_morpholo0.34257441
159MP0002796_impaired_skin_barrier0.33967798
160MP0001545_abnormal_hematopoietic_system0.33534879
161MP0005397_hematopoietic_system_phenotyp0.33534879
162MP0001243_abnormal_dermal_layer0.33291301
163MP0009053_abnormal_anal_canal0.33228259
164MP0008770_decreased_survivor_rate0.28970137
165MP0003075_altered_response_to0.28786333
166MP0002970_abnormal_white_adipose0.28784376
167MP0003633_abnormal_nervous_system0.28705693
168MP0005670_abnormal_white_adipose0.28349853
169MP0010678_abnormal_skin_adnexa0.27369251
170MP0005452_abnormal_adipose_tissue0.27189303
171MP0003111_abnormal_nucleus_morphology0.25765340
172MP0010771_integument_phenotype0.25487968

Predicted human phenotypes

RankGene SetZ-score
1Poikilocytosis (HP:0004447)7.85999920
2Abnormality of the heme biosynthetic pathway (HP:0010472)7.29663427
3Acanthocytosis (HP:0001927)6.89752508
4Intrahepatic cholestasis (HP:0001406)6.40728425
5Abnormality of aromatic amino acid family metabolism (HP:0004338)6.00085056
6Hypochromic microcytic anemia (HP:0004840)5.85676437
7Deep venous thrombosis (HP:0002625)5.79175046
8Reticulocytosis (HP:0001923)5.33654451
9Xanthomatosis (HP:0000991)5.21401554
10Hyperbilirubinemia (HP:0002904)5.20330447
11Abnormality of monocarboxylic acid metabolism (HP:0010996)5.10360155
12Cholelithiasis (HP:0001081)5.06565770
13Prolonged partial thromboplastin time (HP:0003645)4.94095895
14Abnormal gallbladder morphology (HP:0012437)4.93283161
15Hypobetalipoproteinemia (HP:0003563)4.88926975
16Hyperlipoproteinemia (HP:0010980)4.56189539
17Abnormal gallbladder physiology (HP:0012438)4.17019861
18Cholecystitis (HP:0001082)4.17019861
19Abnormality of methionine metabolism (HP:0010901)3.71726804
20Complement deficiency (HP:0004431)3.70261016
21Abnormality of sulfur amino acid metabolism (HP:0004339)3.66908873
22Hyperammonemia (HP:0001987)3.62677962
23Abnormality of the gallbladder (HP:0005264)3.61971143
24Hypolipoproteinemia (HP:0010981)3.59464230
25Abnormality of aspartate family amino acid metabolism (HP:0010899)3.54050069
26Progressive external ophthalmoplegia (HP:0000590)3.51972177
27Joint hemorrhage (HP:0005261)3.49564307
28Epidermoid cyst (HP:0200040)3.46195995
29Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.45562063
30Ankyloglossia (HP:0010296)3.40984207
31Abnormality of the common coagulation pathway (HP:0010990)3.40053320
32Paralysis (HP:0003470)3.35435365
33Ketosis (HP:0001946)3.34770262
34Hyperglycinemia (HP:0002154)3.33604610
35Fat malabsorption (HP:0002630)3.32074688
36Hepatocellular carcinoma (HP:0001402)3.26664410
37Abnormality of serine family amino acid metabolism (HP:0010894)3.22782027
38Abnormality of glycine metabolism (HP:0010895)3.22782027
39Abnormality of reticulocytes (HP:0004312)3.14838944
40Hypoalphalipoproteinemia (HP:0003233)3.06463304
41Chromsome breakage (HP:0040012)3.02191409
42Hypoglycemic coma (HP:0001325)2.99154865
43Chromosomal breakage induced by crosslinking agents (HP:0003221)2.98226268
44Ileus (HP:0002595)2.97280230
45* Insomnia (HP:0100785)2.96195697
46Abnormality of glutamine family amino acid metabolism (HP:0010902)2.87898882
47Metabolic acidosis (HP:0001942)2.78881540
48Abnormality of oral frenula (HP:0000190)2.75621403
49Orthostatic hypotension (HP:0001278)2.75238027
50Abnormal hemoglobin (HP:0011902)2.72672068
51Abnormality of iron homeostasis (HP:0011031)2.72594817
52Abnormality of pyrimidine metabolism (HP:0004353)2.72558071
53Hypercholesterolemia (HP:0003124)2.70138815
54Osteomalacia (HP:0002749)2.68780624
55Dysmetric saccades (HP:0000641)2.67618625
56Hyperglycinuria (HP:0003108)2.67199748
57Increased nuchal translucency (HP:0010880)2.66267329
58Rickets (HP:0002748)2.65377253
59Abnormality of transition element cation homeostasis (HP:0011030)2.65368662
60Increased serum ferritin (HP:0003281)2.63704963
61Abnormality of the intrinsic pathway (HP:0010989)2.63318065
62Microcytic anemia (HP:0001935)2.58370796
63Abnormality of complement system (HP:0005339)2.57938667
64Polycythemia (HP:0001901)2.56370473
65Conjugated hyperbilirubinemia (HP:0002908)2.56152449
66Steatorrhea (HP:0002570)2.53856820
67Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.52874583
68Abnormality of fatty-acid metabolism (HP:0004359)2.52217322
69Delayed CNS myelination (HP:0002188)2.52056354
70Termporal pattern (HP:0011008)2.48838216
71Insidious onset (HP:0003587)2.48838216
72Leiomyosarcoma (HP:0100243)2.45054496
73Uterine leiomyosarcoma (HP:0002891)2.45054496
74Hypochromic anemia (HP:0001931)2.43214459
75Abnormality of serum amino acid levels (HP:0003112)2.42938940
76Pallor (HP:0000980)2.40718628
77Microvesicular hepatic steatosis (HP:0001414)2.39996060
78Progressive muscle weakness (HP:0003323)2.36241362
79Hyperacusis (HP:0010780)2.30847042
80Spastic paraparesis (HP:0002313)2.30196795
81Missing ribs (HP:0000921)2.29377379
82Abnormality of nucleobase metabolism (HP:0010932)2.28439232
83Brushfield spots (HP:0001088)2.23896679
84Malignant gastrointestinal tract tumors (HP:0006749)2.21676215
85Gastrointestinal carcinoma (HP:0002672)2.21676215
86Ketoacidosis (HP:0001993)2.21613949
87Hypertensive crisis (HP:0100735)2.21128766
88Abnormality of the gastric mucosa (HP:0004295)2.20265356
89Poikiloderma (HP:0001029)2.19024311
90Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.18697813
91Birth length less than 3rd percentile (HP:0003561)2.18610423
92Squamous cell carcinoma (HP:0002860)2.17537879
93Pili torti (HP:0003777)2.17151797
94Hypophosphatemic rickets (HP:0004912)2.15509691
95Neurofibrillary tangles (HP:0002185)2.15252264
96Spontaneous abortion (HP:0005268)2.14780742
97Abnormality of dicarboxylic acid metabolism (HP:0010995)2.14296216
98Dicarboxylic aciduria (HP:0003215)2.14296216
99Abnormality of the fingertips (HP:0001211)2.11917827
100Lethargy (HP:0001254)2.11137590
101Multiple enchondromatosis (HP:0005701)2.09667506
102Cerebral edema (HP:0002181)2.09239861
10311 pairs of ribs (HP:0000878)2.07335084
104Abnormality of purine metabolism (HP:0004352)2.06379813
105Microglossia (HP:0000171)2.05716769
106Abnormality of cells of the erythroid lineage (HP:0012130)2.05606040
107Cerebral inclusion bodies (HP:0100314)2.05528501
108Transitional cell carcinoma of the bladder (HP:0006740)2.04604352
109Onycholysis (HP:0001806)2.04598449
110Entropion (HP:0000621)2.03350345
111Bladder neoplasm (HP:0009725)2.03156816
112Bladder carcinoma (HP:0002862)2.03156816
113Fatigue (HP:0012378)2.02447781
114Decreased number of large peripheral myelinated nerve fibers (HP:0003387)2.01823582
115Global brain atrophy (HP:0002283)2.01702753
116Overlapping toe (HP:0001845)2.01451416
117Vascular calcification (HP:0004934)2.01224047
118Cafe-au-lait spot (HP:0000957)2.00859186
119Upper limb muscle weakness (HP:0003484)2.00095195
120Hemorrhage of the eye (HP:0011885)1.98620275
121Irritability (HP:0000737)1.97010287
122Deviation of the thumb (HP:0009603)1.94323189
123Gingival bleeding (HP:0000225)1.94085131
124Cortical dysplasia (HP:0002539)1.93708067
125Myelodysplasia (HP:0002863)1.92438480
126Gastrointestinal stroma tumor (HP:0100723)1.90648525
127Proximal placement of thumb (HP:0009623)1.89619417
128* Vomiting (HP:0002013)1.88078397
129Hypoglycemic seizures (HP:0002173)1.87865933
130Renal cell carcinoma (HP:0005584)1.86862313
131Myocardial infarction (HP:0001658)1.86331553
132Uterine neoplasm (HP:0010784)1.86234264
133Reticulocytopenia (HP:0001896)1.85783983
134Acute myeloid leukemia (HP:0004808)1.85596174
135Degeneration of the lateral corticospinal tracts (HP:0002314)1.85119639
136Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.85119639
137Nonimmune hydrops fetalis (HP:0001790)1.83873374
138Ridged nail (HP:0001807)1.83535198
139Amyloidosis (HP:0011034)1.83419051
140Skin nodule (HP:0200036)1.82449144
141Subacute progressive viral hepatitis (HP:0006572)1.81617768
142Nausea (HP:0002018)1.81311411
143Vertebral arch anomaly (HP:0008438)1.80685142
144Gout (HP:0001997)1.80670761
145Abnormality of glycolysis (HP:0004366)1.79489748
146Increased serum pyruvate (HP:0003542)1.79489748
147Opisthotonus (HP:0002179)1.76461976
148Neoplasm of the colon (HP:0100273)1.76301432
149IgA deficiency (HP:0002720)1.76174719
150Spastic diplegia (HP:0001264)1.75353842
151Menorrhagia (HP:0000132)1.75272861
152Lower limb hyperreflexia (HP:0002395)1.75151128
153Sensorimotor neuropathy (HP:0007141)1.75071401
154Axonal loss (HP:0003447)1.74902299
155Abnormality of the preputium (HP:0100587)1.74438198
156Overriding aorta (HP:0002623)1.72889718
157Increased connective tissue (HP:0009025)1.72153053
158Cardiovascular calcification (HP:0011915)1.71707433
159Elfin facies (HP:0004428)1.71570466
160Impaired proprioception (HP:0010831)1.71106947
161Osteolytic defects of the hand bones (HP:0009699)1.70786364
162Osteolytic defects of the phalanges of the hand (HP:0009771)1.70786364
163Malnutrition (HP:0004395)1.70781323
164Abnormality of urine glucose concentration (HP:0011016)1.69662997
165Glycosuria (HP:0003076)1.69662997
166Osteomyelitis (HP:0002754)1.69553874
167Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.68590797
168Viral hepatitis (HP:0006562)1.66005781
169Progressive hearing impairment (HP:0001730)1.64096303
170Short middle phalanx of the 5th finger (HP:0004220)1.63258631
171Nephroblastoma (Wilms tumor) (HP:0002667)1.63026862
172Relative macrocephaly (HP:0004482)1.61836253
173Basal cell carcinoma (HP:0002671)1.60660580
174Aplasia cutis congenita (HP:0001057)1.60332518
175Long palpebral fissure (HP:0000637)1.59060458
176Increased mean platelet volume (HP:0011877)1.57976111
177Selective tooth agenesis (HP:0001592)1.55702496
178Toxemia of pregnancy (HP:0100603)1.54716956
179Aplasia/Hypoplasia of the sacrum (HP:0008517)1.54468439
180Premature skin wrinkling (HP:0100678)1.54190872

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK14.67423121
2BCKDK4.13170421
3STK393.68706247
4TLK13.47729424
5MST43.21151433
6PRPF4B3.18377292
7SCYL23.00528801
8EPHB12.92770508
9BUB12.92311131
10SMG12.66497449
11STK42.65770733
12TAOK32.54437066
13PBK2.52582817
14OXSR12.40510563
15PKN12.37368167
16SIK12.33359021
17MET2.24837143
18MAPKAPK52.11767238
19MAPK111.94753778
20WEE11.86007927
21WNK41.84784689
22FGFR41.77229869
23TAF11.66675896
24NEK21.65426524
25TSSK61.63322312
26ERBB41.62982138
27NEK11.59879718
28EIF2AK31.50628063
29CDK121.50503500
30ERN11.49394065
31RPS6KA51.40019535
32KSR21.37752376
33TRIB31.36455445
34CDC71.34831460
35STK101.31167382
36ABL21.29914891
37MAP3K101.26757007
38ICK1.26062732
39BMPR21.25586375
40LATS21.24751115
41NEK91.23631577
42MAP3K81.23418639
43SRPK11.22005707
44MAP3K141.21795111
45CHEK21.21585682
46SGK4941.21384834
47SGK2231.21384834
48JAK21.21140053
49INSRR1.19180273
50BRAF1.18911340
51TAOK21.17349241
52CCNB11.15416140
53ERBB21.14709805
54RPS6KB21.13551489
55STK241.11263086
56GRK61.07465452
57PKN21.05682359
58TRPM71.05022577
59MAP2K31.04387669
60MAP3K111.01556614
61FLT30.99157461
62CDK60.98970253
63PRKAA20.98624870
64PLK40.94829144
65PRKCQ0.92676657
66BMX0.91647911
67DYRK30.88207437
68KSR10.88060213
69PRKAA10.87602532
70PLK10.85634302
71CDK70.85250375
72ZAK0.84516023
73CDK40.84105698
74PASK0.83991676
75CSNK1D0.83961782
76MELK0.82520331
77WNK10.81127774
78IRAK30.79528563
79FGFR20.79307436
80NME20.77150254
81EPHA20.76839422
82AURKA0.76468389
83BRSK10.76188523
84BRSK20.76018768
85ALK0.75864432
86MAP3K130.75654567
87PLK30.75218497
88RAF10.74865070
89TESK20.74484628
90PDPK10.73737518
91STK30.73154601
92MST1R0.71742252
93LATS10.71737285
94AKT20.71317527
95MAP2K20.70950468
96NTRK10.70440442
97RIPK40.70338314
98PRKACG0.69842059
99EIF2AK20.69750904
100PIM10.69416516
101MAPK120.69208496
102PDGFRA0.67682103
103DYRK1B0.67485230
104GSK3A0.66427348
105FGFR10.66321698
106TTK0.65162315
107RPS6KA40.64895962
108MAP2K40.64405534
109DAPK20.64073074
110ATR0.63518248
111CSNK1G30.63028277
112MAP3K70.61227181
113CAMK2G0.60928632
114UHMK10.59976921
115MAP3K90.59143895
116TNIK0.58960050
117LRRK20.56984937
118CSNK1G10.55692943
119MAP3K20.55447145
120CDK190.52985445
121PAK40.52557293
122PINK10.51260668
123CAMK2B0.50416985
124CSNK1A1L0.47878437
125EEF2K0.47635173
126VRK10.46701847
127CDK20.45622795
128ATM0.45350841
129PNCK0.45335436
130CDK80.44366992
131ERBB30.44353484
132PRKD10.43894372
133PDK10.43654473
134FGR0.43640232
135PRKACB0.43297427
136CDK10.41923924
137ARAF0.41718908
138PIK3CG0.41490028
139BRD40.40768360
140MTOR0.40417285
141CSNK2A20.37965312
142SGK10.37130354
143PRKCZ0.36724888
144MAP2K10.36704306
145CAMK1D0.36431133
146DAPK30.36275277
147SGK30.36101764
148CLK10.35066022
149RPS6KA30.34927177
150AURKB0.34203354
151MKNK10.33796973
152TYK20.33768967
153KDR0.33390876
154RET0.32641569
155CSNK1E0.32336155
156YES10.32230667
157CSNK1G20.31322726
158CHEK10.31138162
159MAP3K10.30969035
160CDK90.30873253
161ROCK20.29780620

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001203.90046617
2DNA replication_Homo sapiens_hsa030303.76425560
3Nitrogen metabolism_Homo sapiens_hsa009103.53031766
4Glycine, serine and threonine metabolism_Homo sapiens_hsa002603.03625247
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.92591218
6Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.88369421
7* Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.85955308
8Cell cycle_Homo sapiens_hsa041102.81950266
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.81078479
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.55524930
11Mismatch repair_Homo sapiens_hsa034302.53885204
12Arginine biosynthesis_Homo sapiens_hsa002202.52918553
13Vitamin B6 metabolism_Homo sapiens_hsa007502.46982325
14Tryptophan metabolism_Homo sapiens_hsa003802.42844568
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.31023748
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.28837722
17Complement and coagulation cascades_Homo sapiens_hsa046102.26152581
18Fatty acid degradation_Homo sapiens_hsa000712.24862432
19Butanoate metabolism_Homo sapiens_hsa006502.23491119
20Non-homologous end-joining_Homo sapiens_hsa034502.19763258
21Nucleotide excision repair_Homo sapiens_hsa034202.17730493
22Steroid biosynthesis_Homo sapiens_hsa001002.14480596
23Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.13530366
24Fatty acid elongation_Homo sapiens_hsa000622.10199129
25RNA transport_Homo sapiens_hsa030132.00401387
26Histidine metabolism_Homo sapiens_hsa003401.94763194
27Spliceosome_Homo sapiens_hsa030401.90872954
28Peroxisome_Homo sapiens_hsa041461.89612375
29Propanoate metabolism_Homo sapiens_hsa006401.88798732
30Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.88744551
31Chronic myeloid leukemia_Homo sapiens_hsa052201.79457296
32Fatty acid metabolism_Homo sapiens_hsa012121.77607789
33Thyroid cancer_Homo sapiens_hsa052161.77506067
34mRNA surveillance pathway_Homo sapiens_hsa030151.73691387
35Pentose and glucuronate interconversions_Homo sapiens_hsa000401.72199166
36beta-Alanine metabolism_Homo sapiens_hsa004101.68123720
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.67715137
38Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.64863425
39Chemical carcinogenesis_Homo sapiens_hsa052041.62363835
40Base excision repair_Homo sapiens_hsa034101.61951759
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.60657668
42Sulfur metabolism_Homo sapiens_hsa009201.60249932
43ABC transporters_Homo sapiens_hsa020101.57078453
44PPAR signaling pathway_Homo sapiens_hsa033201.56830105
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.56650973
46Selenocompound metabolism_Homo sapiens_hsa004501.53291883
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.48355360
48Pyruvate metabolism_Homo sapiens_hsa006201.48317544
49Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48164625
50Pancreatic cancer_Homo sapiens_hsa052121.47068593
51Ribosome_Homo sapiens_hsa030101.45501977
52Retinol metabolism_Homo sapiens_hsa008301.45435274
53Folate biosynthesis_Homo sapiens_hsa007901.45156687
54Systemic lupus erythematosus_Homo sapiens_hsa053221.43597863
55Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.43524057
56Caffeine metabolism_Homo sapiens_hsa002321.39805103
57Bile secretion_Homo sapiens_hsa049761.39656659
58Cysteine and methionine metabolism_Homo sapiens_hsa002701.38597748
59Drug metabolism - other enzymes_Homo sapiens_hsa009831.36412103
60Sulfur relay system_Homo sapiens_hsa041221.31578946
61p53 signaling pathway_Homo sapiens_hsa041151.28549395
62Phenylalanine metabolism_Homo sapiens_hsa003601.27048321
63Non-small cell lung cancer_Homo sapiens_hsa052231.23543926
64Arginine and proline metabolism_Homo sapiens_hsa003301.22374807
65Tyrosine metabolism_Homo sapiens_hsa003501.20275316
662-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.19041365
67Fat digestion and absorption_Homo sapiens_hsa049751.17486574
68Staphylococcus aureus infection_Homo sapiens_hsa051501.16797054
69Cyanoamino acid metabolism_Homo sapiens_hsa004601.16119709
70Biosynthesis of amino acids_Homo sapiens_hsa012301.13183852
71Endometrial cancer_Homo sapiens_hsa052131.05327101
72Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.04588413
73Homologous recombination_Homo sapiens_hsa034401.04441558
74Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.04353586
75Renal cell carcinoma_Homo sapiens_hsa052111.03247463
76One carbon pool by folate_Homo sapiens_hsa006701.03036102
77Carbon metabolism_Homo sapiens_hsa012001.02515159
78Herpes simplex infection_Homo sapiens_hsa051680.99678860
79Glutathione metabolism_Homo sapiens_hsa004800.98739972
80Maturity onset diabetes of the young_Homo sapiens_hsa049500.96637383
81MicroRNAs in cancer_Homo sapiens_hsa052060.95998656
82Pyrimidine metabolism_Homo sapiens_hsa002400.95897295
83Oocyte meiosis_Homo sapiens_hsa041140.95355182
84Acute myeloid leukemia_Homo sapiens_hsa052210.95113343
85Epstein-Barr virus infection_Homo sapiens_hsa051690.92973709
86B cell receptor signaling pathway_Homo sapiens_hsa046620.91314040
87Starch and sucrose metabolism_Homo sapiens_hsa005000.91059472
88Small cell lung cancer_Homo sapiens_hsa052220.90688938
89Prostate cancer_Homo sapiens_hsa052150.90625088
90Hepatitis B_Homo sapiens_hsa051610.89432359
91Vitamin digestion and absorption_Homo sapiens_hsa049770.87776054
92Lysine degradation_Homo sapiens_hsa003100.85243465
93Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.85222463
94Apoptosis_Homo sapiens_hsa042100.84429012
95Adherens junction_Homo sapiens_hsa045200.83950466
96Measles_Homo sapiens_hsa051620.83561949
97Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.82998884
98Basal transcription factors_Homo sapiens_hsa030220.82341316
99Colorectal cancer_Homo sapiens_hsa052100.82121681
100HTLV-I infection_Homo sapiens_hsa051660.81766801
101N-Glycan biosynthesis_Homo sapiens_hsa005100.79790441
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.78928532
103ErbB signaling pathway_Homo sapiens_hsa040120.72605571
104Shigellosis_Homo sapiens_hsa051310.69027744
105RNA degradation_Homo sapiens_hsa030180.67129639
106Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.66944912
107Insulin signaling pathway_Homo sapiens_hsa049100.66857454
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.65524378
109Fanconi anemia pathway_Homo sapiens_hsa034600.63804045
110Proteoglycans in cancer_Homo sapiens_hsa052050.62201505
111mTOR signaling pathway_Homo sapiens_hsa041500.61823718
112Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61661068
113Glioma_Homo sapiens_hsa052140.61533554
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.61031294
115Glycerolipid metabolism_Homo sapiens_hsa005610.61014742
116Influenza A_Homo sapiens_hsa051640.59755088
117Proteasome_Homo sapiens_hsa030500.58573331
118Linoleic acid metabolism_Homo sapiens_hsa005910.57193009
119* Metabolic pathways_Homo sapiens_hsa011000.57087078
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.56620386
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56328794
122VEGF signaling pathway_Homo sapiens_hsa043700.53657154
123Pentose phosphate pathway_Homo sapiens_hsa000300.53554001
124HIF-1 signaling pathway_Homo sapiens_hsa040660.51024427
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49576291
126African trypanosomiasis_Homo sapiens_hsa051430.49463927
127Fatty acid biosynthesis_Homo sapiens_hsa000610.49286936
128Inositol phosphate metabolism_Homo sapiens_hsa005620.48728348
129Ether lipid metabolism_Homo sapiens_hsa005650.46558978
130RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45416142
131NF-kappa B signaling pathway_Homo sapiens_hsa040640.44938338
132Neurotrophin signaling pathway_Homo sapiens_hsa047220.44792021
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.44042213
134Prolactin signaling pathway_Homo sapiens_hsa049170.42055518
135TGF-beta signaling pathway_Homo sapiens_hsa043500.41919763
136Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.39563960
137Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.38590676
138Wnt signaling pathway_Homo sapiens_hsa043100.38293953
139Purine metabolism_Homo sapiens_hsa002300.38049601
140Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.34926186
141Alcoholism_Homo sapiens_hsa050340.34764439
142Glycerophospholipid metabolism_Homo sapiens_hsa005640.32223802
143Sphingolipid signaling pathway_Homo sapiens_hsa040710.32017592
144Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30642041
145Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.16339383
146Prion diseases_Homo sapiens_hsa050200.15917754
147Adipocytokine signaling pathway_Homo sapiens_hsa049200.15286953
148Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.13939336
149AMPK signaling pathway_Homo sapiens_hsa041520.06704819
150Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.04907952
151Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.02601554
152Bladder cancer_Homo sapiens_hsa052190.01228541
153Insulin resistance_Homo sapiens_hsa049310.01072191
154Galactose metabolism_Homo sapiens_hsa00052-0.2119278
155Hepatitis C_Homo sapiens_hsa05160-0.2053973
156Mineral absorption_Homo sapiens_hsa04978-0.1974652
157Alzheimers disease_Homo sapiens_hsa05010-0.1911307
158Dorso-ventral axis formation_Homo sapiens_hsa04320-0.1866194
159Protein export_Homo sapiens_hsa03060-0.1676003
160Glucagon signaling pathway_Homo sapiens_hsa04922-0.1544048
161Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970-0.1300358
162Oxidative phosphorylation_Homo sapiens_hsa00190-0.1145580
163Viral carcinogenesis_Homo sapiens_hsa05203-0.1101687
164Regulation of autophagy_Homo sapiens_hsa04140-0.1050866
165Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0955619
166Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.0806386
167Fructose and mannose metabolism_Homo sapiens_hsa00051-0.0795409
168Parkinsons disease_Homo sapiens_hsa05012-0.0610347
169Malaria_Homo sapiens_hsa05144-0.0262405
170Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0195150

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