CPPED1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.30365811
2L-phenylalanine catabolic process (GO:0006559)6.30365811
3antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G6.29386417
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.22301577
5L-phenylalanine metabolic process (GO:0006558)6.22301577
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.19786313
7positive regulation by organism of defense response of other organism involved in symbiotic interact6.19786313
8modulation by symbiont of host immune response (GO:0052553)6.19786313
9positive regulation by symbiont of host defense response (GO:0052509)6.19786313
10modulation by symbiont of host defense response (GO:0052031)6.19786313
11modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.19786313
12negative regulation of cell killing (GO:0031342)6.10766854
13negative regulation of leukocyte mediated cytotoxicity (GO:0001911)6.10766854
14positive regulation of gamma-delta T cell activation (GO:0046645)5.78094677
15aromatic amino acid family catabolic process (GO:0009074)5.54737318
16triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.48274210
17neutrophil activation involved in immune response (GO:0002283)5.46283088
18alpha-linolenic acid metabolic process (GO:0036109)5.37606735
19detection of molecule of bacterial origin (GO:0032490)5.29565987
20lysine catabolic process (GO:0006554)5.26210661
21lysine metabolic process (GO:0006553)5.26210661
22glyoxylate metabolic process (GO:0046487)5.18388585
23antigen processing and presentation of endogenous antigen (GO:0019883)5.10245854
24detection of other organism (GO:0098543)5.09758524
25antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.08183433
26sulfur amino acid catabolic process (GO:0000098)5.05425959
27macrophage activation involved in immune response (GO:0002281)5.03192319
28regulation of B cell receptor signaling pathway (GO:0050855)4.99484401
29kynurenine metabolic process (GO:0070189)4.96182043
30cysteine metabolic process (GO:0006534)4.95079277
31indole-containing compound catabolic process (GO:0042436)4.89189010
32indolalkylamine catabolic process (GO:0046218)4.89189010
33tryptophan catabolic process (GO:0006569)4.89189010
34response to peptidoglycan (GO:0032494)4.78322721
35detection of external biotic stimulus (GO:0098581)4.77366164
36cellular extravasation (GO:0045123)4.76015644
37bile acid biosynthetic process (GO:0006699)4.75241595
38fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.74419268
39detection of bacterium (GO:0016045)4.68159126
40tryptophan metabolic process (GO:0006568)4.59812908
41amino-acid betaine metabolic process (GO:0006577)4.57510724
42antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.52118888
43microglial cell activation (GO:0001774)4.49990846
44positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)4.44056339
45urea metabolic process (GO:0019627)4.43041779
46urea cycle (GO:0000050)4.43041779
47neutrophil activation (GO:0042119)4.42756854
48cellular ketone body metabolic process (GO:0046950)4.39093843
49high-density lipoprotein particle remodeling (GO:0034375)4.38632757
50short-chain fatty acid metabolic process (GO:0046459)4.38306717
51serine family amino acid catabolic process (GO:0009071)4.37697481
52regulation of interferon-beta biosynthetic process (GO:0045357)4.37280617
53negative regulation of interleukin-12 production (GO:0032695)4.34801592
54negative regulation of fibrinolysis (GO:0051918)4.33709192
55protein carboxylation (GO:0018214)4.33597243
56peptidyl-glutamic acid carboxylation (GO:0017187)4.33597243
57regulation of triglyceride catabolic process (GO:0010896)4.30985926
58fatty acid beta-oxidation (GO:0006635)4.28252691
59response to interleukin-15 (GO:0070672)4.25141460
60homocysteine metabolic process (GO:0050667)4.24140649
61negative regulation of lymphocyte mediated immunity (GO:0002707)4.21010140
62response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.17066994
63response to host immune response (GO:0052572)4.17066994
64detection of biotic stimulus (GO:0009595)4.17048991
65complement activation, alternative pathway (GO:0006957)4.15667002
66alpha-amino acid catabolic process (GO:1901606)4.14537347
67ethanol oxidation (GO:0006069)4.14081205
68acetyl-CoA metabolic process (GO:0006084)4.13896934
69positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.12704198
70aspartate family amino acid catabolic process (GO:0009068)4.12386222
712-oxoglutarate metabolic process (GO:0006103)4.09796675
72bile acid metabolic process (GO:0008206)4.09753888
73regulation of gamma-delta T cell activation (GO:0046643)4.08540072
74leukocyte migration involved in inflammatory response (GO:0002523)4.08432124
75nitrogen cycle metabolic process (GO:0071941)4.07664378
76aromatic amino acid family metabolic process (GO:0009072)4.05692310
77fatty acid oxidation (GO:0019395)4.05162703
78macrophage activation (GO:0042116)4.03789677
79regulation of protein activation cascade (GO:2000257)4.03572689
80respiratory burst (GO:0045730)4.02710534
81neutrophil mediated immunity (GO:0002446)4.02668292
82regulation of fibrinolysis (GO:0051917)4.01224032
83cellular amino acid catabolic process (GO:0009063)4.01100229
84cellular modified amino acid catabolic process (GO:0042219)3.98154110
85lipid oxidation (GO:0034440)3.97678697
86leukocyte aggregation (GO:0070486)3.96860948
87positive regulation of fatty acid beta-oxidation (GO:0032000)3.96685403
88granulocyte activation (GO:0036230)3.96466624
89reverse cholesterol transport (GO:0043691)3.94496128
90glutamate metabolic process (GO:0006536)3.93498412
91acylglycerol homeostasis (GO:0055090)3.92957372
92triglyceride homeostasis (GO:0070328)3.92957372
93fatty acid catabolic process (GO:0009062)3.90788630
94valine metabolic process (GO:0006573)3.90673643
95coenzyme catabolic process (GO:0009109)3.90163647
96regulation of mast cell degranulation (GO:0043304)3.85272381
97immunoglobulin mediated immune response (GO:0016064)3.85088525
98carnitine metabolic process (GO:0009437)3.84693182
99response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.83315616
100response to host (GO:0075136)3.83315616
101response to host defenses (GO:0052200)3.83315616
102plasma lipoprotein particle remodeling (GO:0034369)3.83121330
103protein-lipid complex remodeling (GO:0034368)3.83121330
104macromolecular complex remodeling (GO:0034367)3.83121330
105positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.83107324
106dicarboxylic acid biosynthetic process (GO:0043650)3.82876994
107regulation of cholesterol esterification (GO:0010872)3.82788214
108cellular response to interleukin-15 (GO:0071350)3.81084401
109tyrosine metabolic process (GO:0006570)3.80958003
110regulation of complement activation (GO:0030449)3.80297778
111monocarboxylic acid catabolic process (GO:0072329)3.79473978
112ketone body metabolic process (GO:1902224)3.79023291
113positive regulation of lipid catabolic process (GO:0050996)3.74771168
114plasma lipoprotein particle clearance (GO:0034381)3.74346826
115myeloid cell activation involved in immune response (GO:0002275)3.74064926
116branched-chain amino acid catabolic process (GO:0009083)3.73510956
117organic acid catabolic process (GO:0016054)3.71302556
118carboxylic acid catabolic process (GO:0046395)3.71302556
119negative regulation of cholesterol transport (GO:0032375)3.70796099
120negative regulation of sterol transport (GO:0032372)3.70796099
121positive regulation of mast cell activation (GO:0033005)3.70473357
122cellular glucuronidation (GO:0052695)3.68037820
123drug catabolic process (GO:0042737)3.67925311
124serine family amino acid metabolic process (GO:0009069)3.66823846
125drug transmembrane transport (GO:0006855)3.66561949
126negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.65333202
127negative regulation of leukocyte mediated immunity (GO:0002704)3.63676161
128fatty acid transmembrane transport (GO:1902001)3.62555076
129positive regulation of fatty acid oxidation (GO:0046321)3.61651422
130antigen processing and presentation via MHC class Ib (GO:0002475)3.60889505
131phospholipid efflux (GO:0033700)3.59758256
132regulation of gamma-delta T cell differentiation (GO:0045586)3.59628311
133regulation of mast cell activation involved in immune response (GO:0033006)3.58969281
134negative regulation of T cell mediated immunity (GO:0002710)3.55344030
135glycine metabolic process (GO:0006544)3.54847221
136regulation of cholesterol homeostasis (GO:2000188)3.54816301
137branched-chain amino acid metabolic process (GO:0009081)3.53833848
138regulation of myeloid leukocyte mediated immunity (GO:0002886)3.51903954
139indolalkylamine metabolic process (GO:0006586)3.49241853
140regulation of fatty acid beta-oxidation (GO:0031998)3.48951511
141production of molecular mediator involved in inflammatory response (GO:0002532)3.47459926
142regulation of mast cell activation (GO:0033003)3.46555391
143serine family amino acid biosynthetic process (GO:0009070)3.44808179
144bile acid and bile salt transport (GO:0015721)3.43740477
145benzene-containing compound metabolic process (GO:0042537)3.42321013
146flavonoid metabolic process (GO:0009812)3.41831768
147carnitine shuttle (GO:0006853)3.41542502
148B cell receptor signaling pathway (GO:0050853)3.36630620
149phospholipid homeostasis (GO:0055091)3.35600752
150epoxygenase P450 pathway (GO:0019373)3.35526120
151urate metabolic process (GO:0046415)3.33979419
152myeloid leukocyte mediated immunity (GO:0002444)3.32855378
153cholesterol efflux (GO:0033344)3.32426888
154regulation of cholesterol metabolic process (GO:0090181)3.31489424
155regulation of leukocyte degranulation (GO:0043300)3.30791974
156arginine metabolic process (GO:0006525)3.30551386
157biotin metabolic process (GO:0006768)3.28384422
158negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.26844374
159regulation of fatty acid oxidation (GO:0046320)3.26080082
160positive regulation of triglyceride metabolic process (GO:0090208)3.25244001
161cholesterol homeostasis (GO:0042632)3.24273098
162dendritic cell migration (GO:0036336)3.23312137
163regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.23089504
164sterol homeostasis (GO:0055092)3.22499227
165regulation of tolerance induction (GO:0002643)3.21226822
166positive regulation of mast cell degranulation (GO:0043306)3.18893315
167positive regulation of mast cell activation involved in immune response (GO:0033008)3.18893315
168regulation of T cell tolerance induction (GO:0002664)3.17908967
169leukocyte degranulation (GO:0043299)3.15216286
170positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.15103725
171regulation of B cell differentiation (GO:0045577)3.14181768
172regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.12851788
173B cell mediated immunity (GO:0019724)3.10008971
174positive regulation of B cell differentiation (GO:0045579)3.08399617
175negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.06689942
176negative regulation of T-helper cell differentiation (GO:0045623)3.06689942
177regulation of tumor necrosis factor biosynthetic process (GO:0042534)3.06197547
178positive regulation of cellular amide metabolic process (GO:0034250)3.06051452
179lipopolysaccharide-mediated signaling pathway (GO:0031663)3.05159639
180dendritic cell chemotaxis (GO:0002407)3.03898348
181cellular response to type I interferon (GO:0071357)3.02771943
182type I interferon signaling pathway (GO:0060337)3.02771943
183response to type I interferon (GO:0034340)3.00477938
184interferon-gamma-mediated signaling pathway (GO:0060333)2.98842246
185regulation of T-helper 2 cell differentiation (GO:0045628)2.98739598
186defense response to protozoan (GO:0042832)2.98407491
187myeloid leukocyte activation (GO:0002274)2.96244817
188positive regulation of interferon-alpha production (GO:0032727)2.94767427
189positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.92931982
190regulation of regulated secretory pathway (GO:1903305)2.92388938
191positive regulation of T cell mediated cytotoxicity (GO:0001916)2.92197790
192regulation of T cell mediated cytotoxicity (GO:0001914)2.91959698
193negative thymic T cell selection (GO:0045060)2.91203623
194negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.86236641
195response to muramyl dipeptide (GO:0032495)2.85887574
196negative regulation of phagocytosis (GO:0050765)2.85393122
197negative T cell selection (GO:0043383)2.84501821
198negative regulation of type 2 immune response (GO:0002829)2.83584110
199germinal center formation (GO:0002467)2.82805520
200negative regulation of interleukin-6 production (GO:0032715)2.80804432

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RXR_22158963_ChIP-Seq_LIVER_Mouse7.23491548
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.68859476
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.25178770
4IRF8_22096565_ChIP-ChIP_GC-B_Human5.66840754
5LXR_22158963_ChIP-Seq_LIVER_Mouse5.61173061
6BP1_19119308_ChIP-ChIP_Hs578T_Human4.91074782
7EGR1_23403033_ChIP-Seq_LIVER_Mouse4.89452271
8IRF8_21731497_ChIP-ChIP_J774_Mouse4.47114669
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.38840626
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.84969521
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.80942333
12NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.78542931
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.75952150
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.68594670
15SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.40343631
16IRF8_27001747_Chip-Seq_BMDM_Mouse3.38688783
17TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.32385203
18MYB_21317192_ChIP-Seq_ERMYB_Mouse3.02103098
19* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.95574679
20IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.89744889
21SPI1_23547873_ChIP-Seq_NB4_Human2.88267977
22RUNX_20019798_ChIP-Seq_JUKART_Human2.76650070
23CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.73079315
24SPI1_23127762_ChIP-Seq_K562_Human2.71411153
25STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.67766696
26RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.46048798
27CLOCK_20551151_ChIP-Seq_293T_Human2.42859654
28SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.41057966
29VDR_24763502_ChIP-Seq_THP-1_Human2.38281379
30SCL_19346495_ChIP-Seq_HPC-7_Human2.36203103
31MYB_26560356_Chip-Seq_TH2_Human2.30137227
32FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.17621500
33SMAD_19615063_ChIP-ChIP_OVARY_Human2.16292723
34RUNX1_22412390_ChIP-Seq_EML_Mouse2.14124023
35BRD4_27068464_Chip-Seq_AML-cells_Mouse2.13504969
36STAT4_19710469_ChIP-ChIP_TH1__Mouse2.08144322
37RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08109660
38MAF_26560356_Chip-Seq_TH1_Human2.06947406
39VDR_21846776_ChIP-Seq_THP-1_Human2.02429856
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.01711465
41ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.1355668
42* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.95956670
43* MYB_26560356_Chip-Seq_TH1_Human1.95455241
44CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.91004089
45VDR_24787735_ChIP-Seq_THP-1_Human1.90609513
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.84619595
47ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.82603522
48UTX_26944678_Chip-Seq_JUKART_Human1.82047111
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.80896347
50MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.78108278
51GATA3_27048872_Chip-Seq_THYMUS_Human1.75955306
52LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.73134085
53PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.68828311
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.65382314
55FOXA2_19822575_ChIP-Seq_HepG2_Human1.64595813
56LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.63101006
57CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.61697625
58EGR1_19374776_ChIP-ChIP_THP-1_Human1.59833321
59GATA3_26560356_Chip-Seq_TH2_Human1.50107298
60TCF7_22412390_ChIP-Seq_EML_Mouse1.48055614
61FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46032644
62PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.45262170
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44633199
64TRIM28_21343339_ChIP-Seq_HEK293_Human1.44522519
65ZNF263_19887448_ChIP-Seq_K562_Human1.43543255
66THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.43115753
67PU_27001747_Chip-Seq_BMDM_Mouse1.41612873
68ESR2_21235772_ChIP-Seq_MCF-7_Human1.41292749
69GATA2_22383799_ChIP-Seq_G1ME_Mouse1.40403814
70MYC_22102868_ChIP-Seq_BL_Human1.40050175
71ELF1_17652178_ChIP-ChIP_JURKAT_Human1.39776745
72MAF_26560356_Chip-Seq_TH2_Human1.39338117
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.38966113
74GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.38010100
75ESR1_20079471_ChIP-ChIP_T-47D_Human1.36134077
76* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.36064193
77PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35966785
78* PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.34425042
79CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.32707257
80PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30793908
81GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.30376599
82HNF4A_19822575_ChIP-Seq_HepG2_Human1.29277487
83KDM2B_26808549_Chip-Seq_SUP-B15_Human1.27782668
84CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27426653
85SOX2_27498859_Chip-Seq_STOMACH_Mouse1.26847564
86CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.26497818
87STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.24894646
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.21307610
89TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.19538058
90SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17449903
91ESR1_15608294_ChIP-ChIP_MCF-7_Human1.15626533
92PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.13914156
93SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.13055229
94KDM2B_26808549_Chip-Seq_DND41_Human1.08848555
95CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.08045755
96SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.07264822
97KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.06773825
98ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06524923
99NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.06494608
100TBX20_22328084_ChIP-Seq_HEART_Mouse1.05122403
101TBX20_22080862_ChIP-Seq_HEART_Mouse1.05122403
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.04826104
103ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.04546108
104RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.04156820
105ESR1_21235772_ChIP-Seq_MCF-7_Human1.03940543
106NRF2_20460467_ChIP-Seq_MEFs_Mouse1.03821791
107NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.03821791
108VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.02725710
109GATA4_25053715_ChIP-Seq_YYC3_Human0.98799860
110BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.98626911
111CDX2_20551321_ChIP-Seq_CACO-2_Human0.96995025
112PU.1_20513432_ChIP-Seq_Bcells_Mouse0.96488468
113PPAR_26484153_Chip-Seq_NCI-H1993_Human0.96330702
114TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.96130345
115GATA1_22025678_ChIP-Seq_K562_Human0.94613325
116GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94230897
117EP300_21415370_ChIP-Seq_HL-1_Mouse0.91539116
118HTT_18923047_ChIP-ChIP_STHdh_Human0.91255548
119BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.90536259
120ELK3_25401928_ChIP-Seq_HUVEC_Human0.89473648
121LXR_22292898_ChIP-Seq_THP-1_Human0.88509909
122ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.87648726
123SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87569799
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.87511732
125PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86302866
126RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85715992
127NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.85302909
128IKZF1_21737484_ChIP-ChIP_HCT116_Human0.83048659
129SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.82925590
130AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.82408567
131BCL6_27268052_Chip-Seq_Bcells_Human0.82261411
132STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.81794489
133AUTS2_25519132_ChIP-Seq_293T-REX_Human0.80958970
134NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.78840516
135SPI1_20517297_ChIP-Seq_HL60_Human0.78773444
136* RXRA_24833708_ChIP-Seq_LIVER_Mouse0.78285147
137TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.78274914
138SOX2_20726797_ChIP-Seq_SW620_Human0.76797647
139STAT3_1855785_ChIP-Seq_MESCs_Mouse0.73805060
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.72562089
141RBPJ_22232070_ChIP-Seq_NCS_Mouse0.70582474
142SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.69010547
143RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.67775251
144RACK7_27058665_Chip-Seq_MCF-7_Human0.66592570
145GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.65613419
146ERG_21242973_ChIP-ChIP_JURKAT_Human0.65110993
147IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.63333539
148GATA2_19941826_ChIP-Seq_K562_Human0.63330466
149Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.61517945
150GATA1_19941826_ChIP-Seq_K562_Human0.60633056
151PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.60353887
152NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.60349171
153* BCAT_22108803_ChIP-Seq_LS180_Human0.60328705
154* AR_20517297_ChIP-Seq_VCAP_Human0.60073462
155GATA2_21666600_ChIP-Seq_HMVEC_Human0.59552587
156GATA3_24758297_ChIP-Seq_MCF-7_Human0.59354625
157RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.58896466
158ATF3_27146783_Chip-Seq_COLON_Human0.58833732
159TP63_17297297_ChIP-ChIP_HaCaT_Human0.58496955
160ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.58473872
161GATA6_25053715_ChIP-Seq_YYC3_Human0.57802798
162ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.56757609
163CDX2_19796622_ChIP-Seq_MESCs_Mouse0.56385305
164* RARA_24833708_ChIP-Seq_LIVER_Mouse0.56085144
165CJUN_26792858_Chip-Seq_BT549_Human0.55363926
166PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.55264751
167HIF1A_21447827_ChIP-Seq_MCF-7_Human0.55006047
168FOXA1_25552417_ChIP-Seq_VCAP_Human0.54830108
169EGR1_19032775_ChIP-ChIP_M12_Human0.54748794
170GATA1_19941827_ChIP-Seq_MEL_Mouse0.54234843
171KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.52974929
172CBP_21632823_ChIP-Seq_H3396_Human0.52044895
173MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.51445129
174SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.51410838
175FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.51290264
176CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.50441911
177CEBPB_22108803_ChIP-Seq_LS180_Human0.49384903
178FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.49383335
179P63_26484246_Chip-Seq_KERATINOCYTES_Human0.49315643

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.99236884
2MP0005360_urolithiasis6.83171584
3MP0005085_abnormal_gallbladder_physiolo5.58924056
4MP0003724_increased_susceptibility_to5.23807067
5MP0005365_abnormal_bile_salt5.19628491
6MP0008875_abnormal_xenobiotic_pharmacok4.33453325
7MP0003806_abnormal_nucleotide_metabolis4.18106060
8MP0003436_decreased_susceptibility_to4.10962791
9MP0001835_abnormal_antigen_presentation3.78590634
10MP0003303_peritoneal_inflammation3.59181914
11MP0003252_abnormal_bile_duct3.53379988
12MP0010329_abnormal_lipoprotein_level3.21713083
13MP0002419_abnormal_innate_immunity3.13408525
14MP0003195_calcinosis2.99197171
15MP0005332_abnormal_amino_acid2.90720802
16MP0009840_abnormal_foam_cell2.89640554
17MP0009785_altered_susceptibility_to2.77374533
18MP0005025_abnormal_response_to2.77091857
19MP0001800_abnormal_humoral_immune2.75571432
20MP0005671_abnormal_response_to2.74955401
21MP0000685_abnormal_immune_system2.73094884
22MP0006082_CNS_inflammation2.67491878
23MP0005000_abnormal_immune_tolerance2.62361703
24MP0001666_abnormal_nutrient_absorption2.50077598
25MP0005387_immune_system_phenotype2.49607751
26MP0001790_abnormal_immune_system2.49607751
27MP0002723_abnormal_immune_serum2.46639046
28MP0005083_abnormal_biliary_tract2.42248818
29MP0005464_abnormal_platelet_physiology2.40628956
30MP0002452_abnormal_antigen_presenting2.38384411
31MP0002420_abnormal_adaptive_immunity2.37542762
32MP0001819_abnormal_immune_cell2.35031799
33MP0008260_abnormal_autophagy2.20533833
34MP0002148_abnormal_hypersensitivity_rea2.20154470
35MP0002132_abnormal_respiratory_system2.19651983
36MP0001533_abnormal_skeleton_physiology2.16593599
37MP0003172_abnormal_lysosome_physiology2.13423865
38MP0002118_abnormal_lipid_homeostasis2.07854971
39MP0004130_abnormal_muscle_cell2.06821582
40MP0004019_abnormal_vitamin_homeostasis2.02803026
41MP0003191_abnormal_cellular_cholesterol1.93200878
42MP0002405_respiratory_system_inflammati1.91900313
43MP0000609_abnormal_liver_physiology1.89239664
44MP0003828_pulmonary_edema1.87558464
45MP0003705_abnormal_hypodermis_morpholog1.85499743
46MP0002837_dystrophic_cardiac_calcinosis1.82316746
47MP0005319_abnormal_enzyme/_coenzyme1.81767559
48MP0002398_abnormal_bone_marrow1.77102233
49MP0000716_abnormal_immune_system1.76192629
50MP0003763_abnormal_thymus_physiology1.75575257
51MP0004883_abnormal_blood_vessel1.73652194
52MP0001845_abnormal_inflammatory_respons1.71699918
53MP0003183_abnormal_peptide_metabolism1.68122762
54MP0005584_abnormal_enzyme/coenzyme_acti1.67652978
55MP0010155_abnormal_intestine_physiology1.64452561
56MP0005670_abnormal_white_adipose1.64257566
57MP0000465_gastrointestinal_hemorrhage1.60218208
58MP0002396_abnormal_hematopoietic_system1.58868314
59MP0003866_abnormal_defecation1.58573045
60MP0000689_abnormal_spleen_morphology1.51728720
61MP0009643_abnormal_urine_homeostasis1.48830259
62MP0002722_abnormal_immune_system1.47346751
63MP0009333_abnormal_splenocyte_physiolog1.44938303
64MP0000858_altered_metastatic_potential1.42565485
65MP0004947_skin_inflammation1.41441379
66MP0002277_abnormal_respiratory_mucosa1.40366547
67MP0005164_abnormal_response_to1.40110767
68MP0002429_abnormal_blood_cell1.39785607
69MP0009278_abnormal_bone_marrow1.39399934
70MP0004381_abnormal_hair_follicle1.37010673
71MP0003075_altered_response_to1.36287401
72MP0001764_abnormal_homeostasis1.32932501
73MP0005397_hematopoietic_system_phenotyp1.31720588
74MP0001545_abnormal_hematopoietic_system1.31720588
75MP0003186_abnormal_redox_activity1.31414260
76MP0006036_abnormal_mitochondrial_physio1.29048481
77MP0005666_abnormal_adipose_tissue1.28211285
78MP0002138_abnormal_hepatobiliary_system1.27356629
79MP0003868_abnormal_feces_composition1.22319735
80MP0009697_abnormal_copulation1.21309457
81MP0002166_altered_tumor_susceptibility1.20172630
82MP0000703_abnormal_thymus_morphology1.19806598
83MP0002971_abnormal_brown_adipose1.19600515
84MP0005310_abnormal_salivary_gland1.19015912
85MP0003646_muscle_fatigue1.17200531
86MP0000569_abnormal_digit_pigmentation1.16852198
87MP0001851_eye_inflammation1.16678875
88MP0002998_abnormal_bone_remodeling1.15452415
89MP0003656_abnormal_erythrocyte_physiolo1.15261365
90MP0010368_abnormal_lymphatic_system1.13421294
91MP0005451_abnormal_body_composition1.11281972
92MP0005330_cardiomyopathy1.06669101
93MP0003011_delayed_dark_adaptation1.05100020
94MP0008438_abnormal_cutaneous_collagen1.02686160
95MP0000598_abnormal_liver_morphology1.02546361
96MP0005166_decreased_susceptibility_to1.00726098
97MP0000015_abnormal_ear_pigmentation0.99051551
98MP0002269_muscular_atrophy0.98529626
99MP0005075_abnormal_melanosome_morpholog0.97887040
100MP0006054_spinal_hemorrhage0.97854193
101MP0004043_abnormal_pH_regulation0.97394779
102MP0004084_abnormal_cardiac_muscle0.95446310
103MP0005084_abnormal_gallbladder_morpholo0.95235152
104MP0005636_abnormal_mineral_homeostasis0.95153495
105MP0004036_abnormal_muscle_relaxation0.93672964
106MP0000749_muscle_degeneration0.93253883
107MP0002078_abnormal_glucose_homeostasis0.92472637
108MP0005535_abnormal_body_temperature0.91313761
109MP0000751_myopathy0.89951301
110MP0001853_heart_inflammation0.89216542
111MP0000343_altered_response_to0.85928804
112MP0004087_abnormal_muscle_fiber0.85603152
113MP0003448_altered_tumor_morphology0.85233520
114MP0008004_abnormal_stomach_pH0.85127112
115MP0005266_abnormal_metabolism0.83214261
116MP0004215_abnormal_myocardial_fiber0.82917644
117MP0001756_abnormal_urination0.82771060
118MP0009642_abnormal_blood_homeostasis0.80808920
119MP0005390_skeleton_phenotype0.80223557
120MP0005376_homeostasis/metabolism_phenot0.80139372
121MP0009764_decreased_sensitivity_to0.79940952
122MP0005334_abnormal_fat_pad0.79343259
123MP0000604_amyloidosis0.78047469
124MP0005375_adipose_tissue_phenotype0.76799485
125MP0009763_increased_sensitivity_to0.76583472
126MP0001663_abnormal_digestive_system0.75991869
127MP0004185_abnormal_adipocyte_glucose0.75239708
128MP0003045_fibrosis0.74979757
129MP0005448_abnormal_energy_balance0.74968186
130MP0008775_abnormal_heart_ventricle0.74527559
131MP0006035_abnormal_mitochondrial_morpho0.74452875
132MP0000249_abnormal_blood_vessel0.73361357
133MP0002006_tumorigenesis0.70448085
134MP0008961_abnormal_basal_metabolism0.69919833
135MP0001986_abnormal_taste_sensitivity0.69608576
136MP0000747_muscle_weakness0.66962356
137MP0009115_abnormal_fat_cell0.66923270
138MP0004510_myositis0.66605803
139MP0002933_joint_inflammation0.66147987
140MP0001544_abnormal_cardiovascular_syste0.64658245
141MP0005385_cardiovascular_system_phenoty0.64658245
142MP0002972_abnormal_cardiac_muscle0.64361707
143MP0005620_abnormal_muscle_contractility0.64000995
144MP0005647_abnormal_sex_gland0.63641388
145MP0001958_emphysema0.63496485
146MP0003795_abnormal_bone_structure0.62380451
147MP0002822_catalepsy0.62266859
148MP0005058_abnormal_lysosome_morphology0.61639635
149MP0010630_abnormal_cardiac_muscle0.61543915
150MP0001661_extended_life_span0.61359668
151MP0008469_abnormal_protein_level0.60588577
152MP0003221_abnormal_cardiomyocyte_apopto0.60125646
153MP0004484_altered_response_of0.59193627
154MP0002254_reproductive_system_inflammat0.59121361
155MP0006138_congestive_heart_failure0.58501957
156MP0009384_cardiac_valve_regurgitation0.58479269
157MP0005248_abnormal_Harderian_gland0.58155557
158MP0003300_gastrointestinal_ulcer0.57953924
159MP0003329_amyloid_beta_deposits0.57429483
160MP0000230_abnormal_systemic_arterial0.57083594
161MP0000371_diluted_coat_color0.56913082
162MP0002168_other_aberrant_phenotype0.56589736
163MP0004808_abnormal_hematopoietic_stem0.56406335
164MP0002876_abnormal_thyroid_physiology0.56008441
165MP0002136_abnormal_kidney_physiology0.55908269
166MP0005275_abnormal_skin_tensile0.55779995
167MP0002970_abnormal_white_adipose0.54876816
168MP0005408_hypopigmentation0.52925572
169MP0009765_abnormal_xenobiotic_induced0.51383073
170MP0003690_abnormal_glial_cell0.51175000
171MP0003279_aneurysm0.50279236
172MP0003953_abnormal_hormone_level0.49623086
173MP0005165_increased_susceptibility_to0.47814726
174MP0008874_decreased_physiological_sensi0.46611567
175MP0009780_abnormal_chondrocyte_physiolo0.46353772
176MP0001765_abnormal_ion_homeostasis0.46277410
177MP0010234_abnormal_vibrissa_follicle0.46105707

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)6.46521910
2Recurrent abscess formation (HP:0002722)6.06079344
3Myositis (HP:0100614)6.05575046
4Recurrent bacterial skin infections (HP:0005406)5.99195079
5Abnormality of aromatic amino acid family metabolism (HP:0004338)5.85367712
6Orchitis (HP:0100796)5.80758456
7Intrahepatic cholestasis (HP:0001406)5.77941141
8Deep venous thrombosis (HP:0002625)5.61572076
9Optic neuritis (HP:0100653)5.50020771
10Retrobulbar optic neuritis (HP:0100654)5.50020771
11Abnormality of macrophages (HP:0004311)5.34140289
12Xanthomatosis (HP:0000991)5.30146220
13Recurrent gram-negative bacterial infections (HP:0005420)5.20798202
14Abnormality of monocarboxylic acid metabolism (HP:0010996)5.11299604
15Hypobetalipoproteinemia (HP:0003563)4.96224467
16Stomatitis (HP:0010280)4.92558522
17Hyperammonemia (HP:0001987)4.74131757
18Ketosis (HP:0001946)4.73354835
19Elevated erythrocyte sedimentation rate (HP:0003565)4.72652076
20Gastrointestinal infarctions (HP:0005244)4.55072039
21Hypoglycemic coma (HP:0001325)4.41181134
22Hyperlipoproteinemia (HP:0010980)4.40454718
23Hyperglycinuria (HP:0003108)4.30333515
24Prolonged partial thromboplastin time (HP:0003645)4.17152651
25Recurrent fungal infections (HP:0002841)4.16116170
26Ketoacidosis (HP:0001993)4.15705458
27Hypolipoproteinemia (HP:0010981)4.10647093
28Obstructive lung disease (HP:0006536)4.10407631
29Chronic obstructive pulmonary disease (HP:0006510)4.10407631
30Abnormality of serine family amino acid metabolism (HP:0010894)4.09678681
31Abnormality of glycine metabolism (HP:0010895)4.09678681
32Abnormality of glutamine family amino acid metabolism (HP:0010902)4.08485577
33Recurrent skin infections (HP:0001581)4.04937496
34Hyperglycinemia (HP:0002154)3.97971186
35Keratoconjunctivitis sicca (HP:0001097)3.95547421
36Abnormality of fatty-acid metabolism (HP:0004359)3.91658378
37Complement deficiency (HP:0004431)3.86267050
38Abnormal delayed hypersensitivity skin test (HP:0002963)3.84516447
39Hypoalphalipoproteinemia (HP:0003233)3.84440557
40Meningitis (HP:0001287)3.78877681
41Mediastinal lymphadenopathy (HP:0100721)3.78468166
42Gingival bleeding (HP:0000225)3.78461985
43Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.73466601
44Encephalitis (HP:0002383)3.69335043
45Epidermoid cyst (HP:0200040)3.68175912
46Keratoconjunctivitis (HP:0001096)3.67079036
47Abnormality of aspartate family amino acid metabolism (HP:0010899)3.65103919
48Peritonitis (HP:0002586)3.64494968
49Spontaneous hematomas (HP:0007420)3.64075980
50Prolonged bleeding time (HP:0003010)3.59481646
51Recurrent cutaneous fungal infections (HP:0011370)3.54316690
52Chronic mucocutaneous candidiasis (HP:0002728)3.54316690
53Gingivitis (HP:0000230)3.51703699
54Abnormality of sulfur amino acid metabolism (HP:0004339)3.48095359
55Urticaria (HP:0001025)3.47629805
56Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.45963660
57Vasculitis (HP:0002633)3.43288168
58Episodic fever (HP:0001954)3.42334010
59Abnormality of the common coagulation pathway (HP:0010990)3.35671366
60Amyloidosis (HP:0011034)3.29223402
61Chest pain (HP:0100749)3.24288280
62Dicarboxylic aciduria (HP:0003215)3.24185819
63Abnormality of dicarboxylic acid metabolism (HP:0010995)3.24185819
64Fat malabsorption (HP:0002630)3.21117603
65Hypochromic anemia (HP:0001931)3.19413299
66T lymphocytopenia (HP:0005403)3.18072782
67Epistaxis (HP:0000421)3.14336395
68Arterial thrombosis (HP:0004420)3.13487375
69Hemoptysis (HP:0002105)3.11827677
70Abnormality of T cell number (HP:0011839)3.11714560
71Conjugated hyperbilirubinemia (HP:0002908)3.11379319
72Pulmonary infiltrates (HP:0002113)3.10694571
73Abnormality of methionine metabolism (HP:0010901)3.09686276
74Metabolic acidosis (HP:0001942)3.08086617
75Joint hemorrhage (HP:0005261)3.05279882
76Pulmonary embolism (HP:0002204)3.03176566
77Hyperbilirubinemia (HP:0002904)3.01306304
78Abnormality of serum amino acid levels (HP:0003112)3.00193209
79Increased IgE level (HP:0003212)2.99559887
80Abnormality of purine metabolism (HP:0004352)2.98405512
81Gout (HP:0001997)2.94925648
82Hypercholesterolemia (HP:0003124)2.92776883
83Anorexia (HP:0002039)2.91475737
84Abnormality of the intrinsic pathway (HP:0010989)2.90278092
85Delayed CNS myelination (HP:0002188)2.89542980
86Cerebral edema (HP:0002181)2.87633374
87Myoglobinuria (HP:0002913)2.85519649
88Leukocytosis (HP:0001974)2.83698395
89Cellulitis (HP:0100658)2.83333815
90Lethargy (HP:0001254)2.82580297
91Abnormality of nucleobase metabolism (HP:0010932)2.81993825
92Generalized aminoaciduria (HP:0002909)2.81493792
93Abnormality of complement system (HP:0005339)2.70312833
94Late onset (HP:0003584)2.68733469
95Skin nodule (HP:0200036)2.68685561
96Abnormality of T cells (HP:0002843)2.60006378
97Gangrene (HP:0100758)2.59330742
98Abnormality of the peritoneum (HP:0002585)2.58444912
99Recurrent viral infections (HP:0004429)2.55213194
100Myocardial infarction (HP:0001658)2.53698801
101Pustule (HP:0200039)2.52728476
102Vascular calcification (HP:0004934)2.52572211
103Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.51944530
104Petechiae (HP:0000967)2.49230368
105Abnormality of pyrimidine metabolism (HP:0004353)2.49170450
106Abnormality of the pleura (HP:0002103)2.46153765
107Purpura (HP:0000979)2.45045966
108Vomiting (HP:0002013)2.44659079
109Inflammation of the large intestine (HP:0002037)2.43799864
110Hydroxyprolinuria (HP:0003080)2.43411427
111Abnormality of proline metabolism (HP:0010907)2.43411427
112Microcytic anemia (HP:0001935)2.40387627
113Cardiovascular calcification (HP:0011915)2.39885422
114Osteomyelitis (HP:0002754)2.39607787
115Cholelithiasis (HP:0001081)2.39036610
116Increased IgM level (HP:0003496)2.36300190
117Granulocytopenia (HP:0001913)2.35881669
118Hepatocellular carcinoma (HP:0001402)2.34479147
119Gastrointestinal inflammation (HP:0004386)2.34144972
120Abnormal gallbladder morphology (HP:0012437)2.34039822
121Hypoglycemic seizures (HP:0002173)2.29479240
122Glomerulopathy (HP:0100820)2.29055555
123Proximal tubulopathy (HP:0000114)2.26837032
124Right ventricular cardiomyopathy (HP:0011663)2.26560793
125Abnormal platelet volume (HP:0011876)2.25631135
126Esophageal varix (HP:0002040)2.25282824
127Increased serum ferritin (HP:0003281)2.24987726
128Acute hepatic failure (HP:0006554)2.22888157
129Abnormality of iron homeostasis (HP:0011031)2.22098848
130Panhypogammaglobulinemia (HP:0003139)2.22033561
131Steatorrhea (HP:0002570)2.21457104
132Polycythemia (HP:0001901)2.20786982
133Thrombophlebitis (HP:0004418)2.20670563
134Rhabdomyolysis (HP:0003201)2.20625754
135Neonatal onset (HP:0003623)2.19572467
136Abnormality of T cell physiology (HP:0011840)2.17230825
137Hyperinsulinemic hypoglycemia (HP:0000825)2.16504273
138Hyperuricemia (HP:0002149)2.16423131
139Increased purine levels (HP:0004368)2.16423131
140Sensorimotor neuropathy (HP:0007141)2.16104808
141Keratitis (HP:0000491)2.15885726
142Acne (HP:0001061)2.15566220
143Abnormal gallbladder physiology (HP:0012438)2.14271136
144Cholecystitis (HP:0001082)2.14271136
145Nausea (HP:0002018)2.13626397
146Abnormality of the endocardium (HP:0004306)2.12379605
147Sepsis (HP:0100806)2.12014996
148Hepatic necrosis (HP:0002605)2.11633966
149Vertigo (HP:0002321)2.11490349
150Pancreatitis (HP:0001733)2.11197514
151Increased cerebral lipofuscin (HP:0011813)2.09117803
152Abnormal cartilage morphology (HP:0002763)2.08223688
153Malnutrition (HP:0004395)2.07454287
154Eosinophilia (HP:0001880)2.04288964
155Palpitations (HP:0001962)2.03932442
156Spastic diplegia (HP:0001264)2.03166249
157Abnormality of the Achilles tendon (HP:0005109)2.02260244
158Polyneuropathy (HP:0001271)2.01272607
159Abnormality of glycolipid metabolism (HP:0010969)2.00326929
160Abnormality of liposaccharide metabolism (HP:0010968)2.00326929
161Abnormality of glycosphingolipid metabolism (HP:0004343)2.00326929
162Irritability (HP:0000737)1.97354263
163Skin ulcer (HP:0200042)1.96973061
164Glycosuria (HP:0003076)1.96762664
165Abnormality of urine glucose concentration (HP:0011016)1.96762664
166Menorrhagia (HP:0000132)1.96737509
167Hypergammaglobulinemia (HP:0010702)1.95821178
168Viral hepatitis (HP:0006562)1.95160094
169Abnormality of the pericardium (HP:0001697)1.94979694
170Exercise-induced muscle cramps (HP:0003710)1.94406482
171Subacute progressive viral hepatitis (HP:0006572)1.93927401
172Spontaneous abortion (HP:0005268)1.93625146
173Hemorrhage of the eye (HP:0011885)1.91742487
174Abnormality of transition element cation homeostasis (HP:0011030)1.91730292
175Cheilitis (HP:0100825)1.91213836
176Skin rash (HP:0000988)1.89905931
177Acute encephalopathy (HP:0006846)1.89673815
178Exercise-induced myalgia (HP:0003738)1.89409502
179Lymphopenia (HP:0001888)1.88256634
180Loss of speech (HP:0002371)1.88239917
181Hepatosplenomegaly (HP:0001433)1.86422834
182Mitral stenosis (HP:0001718)1.84974190
183Joint swelling (HP:0001386)1.84828598
184Abnormality of the gallbladder (HP:0005264)1.83529387
185Acanthocytosis (HP:0001927)1.81437086
186Slow saccadic eye movements (HP:0000514)1.81177312
187Opisthotonus (HP:0002179)1.81088028
188Hyperglycemia (HP:0003074)1.79026026
189Hypochromic microcytic anemia (HP:0004840)1.78942690
190Abnormality of cells of the lymphoid lineage (HP:0012140)1.78388940
191Rickets (HP:0002748)1.77849018
192Axonal loss (HP:0003447)1.75725553
193Enlarged kidneys (HP:0000105)1.75684554
194Renal cortical cysts (HP:0000803)1.75031635
195Increased muscle lipid content (HP:0009058)1.73349674
196Systemic lupus erythematosus (HP:0002725)1.73076627

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.45560342
2RIPK44.92784373
3TRIB34.30461190
4ERN13.46575752
5SIK13.43173852
6BLK3.28076680
7MAP4K13.18482654
8IRAK43.12589274
9TYK23.01420865
10CSK2.90241838
11PKN22.89257760
12FGFR42.85865038
13FES2.70444720
14GRK62.31295737
15LMTK22.23831891
16PDK32.20227169
17PDK42.20227169
18ZAP702.12815571
19TNK22.08055752
20MAP3K31.99899347
21JAK31.92929504
22FGR1.91560910
23TTN1.91210077
24TXK1.88787397
25BTK1.84078658
26HCK1.80041093
27SYK1.76843960
28NEK11.72851126
29MST1R1.65536389
30PDGFRA1.61288038
31PRPF4B1.52826041
32MAP3K141.51572935
33PIK3CG1.50867250
34LYN1.44906156
35TIE11.42716357
36MAP3K71.42131139
37INSRR1.40565838
38YES11.37486642
39IKBKE1.35887750
40MYLK1.34485496
41PTK61.33725975
42CSF1R1.32003688
43WNK41.31615204
44MAPK111.29948019
45RIPK11.28918019
46MATK1.28914216
47FLT31.27088627
48LATS11.24078047
49BMPR21.22501645
50TGFBR21.21722864
51LCK1.20009818
52PHKG11.19606121
53PHKG21.19606121
54MAP2K41.17238531
55MAP3K21.17048184
56ITK1.16178879
57NEK91.15528568
58PIK3CA1.15288808
59IRAK11.15213590
60TEC1.14818987
61ERBB41.14198691
62KIT1.13359078
63SIK31.11149655
64FGFR21.10891178
65OBSCN1.10488409
66PDK21.03573886
67PINK11.02924545
68FRK1.02469489
69KDR1.01222284
70CAMK1D0.99463786
71PRKAA20.98942244
72PAK30.97476105
73MARK30.96581683
74EPHB10.95002635
75MAP3K60.93244631
76PTK2B0.91066301
77DAPK20.90065204
78STK100.89054531
79IRAK20.87281491
80PTK20.87034325
81MAP2K30.85650105
82MET0.82674121
83LRRK20.82117922
84MARK20.80867036
85DYRK1B0.79968631
86CDK60.79500154
87MAP2K10.77155886
88MAPK120.77146928
89IKBKB0.76405797
90MAP3K110.75791529
91CDK190.75745188
92PRKAA10.75496363
93ABL20.74256002
94PRKD20.73525004
95DDR20.69546283
96RET0.68013879
97BMX0.66005009
98FYN0.65917320
99CAMK2G0.65299193
100PRKD10.64750258
101SGK30.63579946
102PRKACG0.62603937
103TBK10.62404389
104RAF10.62049734
105FER0.59438437
106GSK3A0.59236463
107FGFR10.57672285
108DAPK30.56975140
109MAP3K10.56760849
110PDPK10.56648534
111WNK10.56398434
112TAOK10.56264789
113STK380.55817312
114PRKCQ0.55801779
115NME20.54969813
116TAOK30.54939764
117JAK20.54861345
118PRKG20.54702703
119DMPK0.53975324
120STK38L0.52148556
121KSR10.50733072
122STK110.50335614
123KSR20.50128243
124MAPK150.50125035
125TESK20.49182711
126FGFR30.48663397
127PAK20.48504258
128CAMKK20.47969099
129ICK0.47770031
130CAMK40.47735946
131CAMKK10.47540254
132EPHA30.46507204
133GRK70.46038103
134SIK20.45945409
135MTOR0.44242094
136MAP3K130.43530667
137NLK0.43246803
138MAPKAPK20.42636077
139SGK20.42394356
140MAP3K50.42299973
141PIM20.41965227
142PIM10.41829643
143MAPK40.41749491
144MAPK70.40616726
145MAP2K60.40519881
146SGK2230.39809424
147SGK4940.39809424
148CDC42BPA0.39687704
149LATS20.39383185
150PDK10.39365870
151TAOK20.38155420
152HIPK20.37827790
153ILK0.36191169
154CAMK2D0.36014952
155AKT20.34689731
156CAMK1G0.34683147
157PRKCZ0.34440694
158WNK30.33747325
159ACVR1B0.33430679
160JAK10.33403924
161MAP3K120.32666844
162SMG10.32620825
163PRKCD0.27626298
164RPS6KC10.27358405

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009103.74802055
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.53450588
3Leishmaniasis_Homo sapiens_hsa051403.32426530
4Osteoclast differentiation_Homo sapiens_hsa043803.05424425
5Fatty acid degradation_Homo sapiens_hsa000712.99454155
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.99148505
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.99143199
8Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.88094965
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.81772964
10Propanoate metabolism_Homo sapiens_hsa006402.78092587
11Arginine biosynthesis_Homo sapiens_hsa002202.75889338
12Tryptophan metabolism_Homo sapiens_hsa003802.59232766
13Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.53023102
14Graft-versus-host disease_Homo sapiens_hsa053322.51831478
15Allograft rejection_Homo sapiens_hsa053302.44415865
16Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.40412262
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.36903082
18Tuberculosis_Homo sapiens_hsa051522.35922926
19Butanoate metabolism_Homo sapiens_hsa006502.33466365
20Autoimmune thyroid disease_Homo sapiens_hsa053202.27935521
21Fatty acid metabolism_Homo sapiens_hsa012122.27162918
22Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.14540290
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046662.13152554
24B cell receptor signaling pathway_Homo sapiens_hsa046622.12837153
25PPAR signaling pathway_Homo sapiens_hsa033202.09187825
26Pentose and glucuronate interconversions_Homo sapiens_hsa000402.07672399
27Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.05685464
28Peroxisome_Homo sapiens_hsa041462.03788449
29Toll-like receptor signaling pathway_Homo sapiens_hsa046202.02166513
30Complement and coagulation cascades_Homo sapiens_hsa046101.99009396
31NOD-like receptor signaling pathway_Homo sapiens_hsa046211.95613298
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.90928866
33Malaria_Homo sapiens_hsa051441.89931230
34Primary immunodeficiency_Homo sapiens_hsa053401.86018825
35Pyruvate metabolism_Homo sapiens_hsa006201.84481741
36Type I diabetes mellitus_Homo sapiens_hsa049401.82306702
37Caffeine metabolism_Homo sapiens_hsa002321.77679555
38Hematopoietic cell lineage_Homo sapiens_hsa046401.76473234
39Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.75541095
40Measles_Homo sapiens_hsa051621.75028146
41beta-Alanine metabolism_Homo sapiens_hsa004101.73440677
42Antigen processing and presentation_Homo sapiens_hsa046121.73333194
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.71538078
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.69555760
45Chemokine signaling pathway_Homo sapiens_hsa040621.68069168
46Carbon metabolism_Homo sapiens_hsa012001.66959746
47Legionellosis_Homo sapiens_hsa051341.64451682
48Histidine metabolism_Homo sapiens_hsa003401.59703326
49Sulfur metabolism_Homo sapiens_hsa009201.57952018
50Toxoplasmosis_Homo sapiens_hsa051451.57672066
51Phagosome_Homo sapiens_hsa041451.54719083
52Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.53851591
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.53674656
54Chemical carcinogenesis_Homo sapiens_hsa052041.53520718
55Starch and sucrose metabolism_Homo sapiens_hsa005001.51936512
56T cell receptor signaling pathway_Homo sapiens_hsa046601.51341755
57Bile secretion_Homo sapiens_hsa049761.50570430
58Acute myeloid leukemia_Homo sapiens_hsa052211.49417504
59Viral myocarditis_Homo sapiens_hsa054161.49209052
60NF-kappa B signaling pathway_Homo sapiens_hsa040641.48549638
61Influenza A_Homo sapiens_hsa051641.47420826
62Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.46852873
63Drug metabolism - other enzymes_Homo sapiens_hsa009831.42314309
64Asthma_Homo sapiens_hsa053101.41478539
65Jak-STAT signaling pathway_Homo sapiens_hsa046301.39803819
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37575868
67Platelet activation_Homo sapiens_hsa046111.37386827
68African trypanosomiasis_Homo sapiens_hsa051431.37137933
69Steroid hormone biosynthesis_Homo sapiens_hsa001401.36305940
70Fatty acid elongation_Homo sapiens_hsa000621.36065717
71Other glycan degradation_Homo sapiens_hsa005111.35341419
72Biosynthesis of amino acids_Homo sapiens_hsa012301.33842226
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.31336533
74Intestinal immune network for IgA production_Homo sapiens_hsa046721.30963278
75Leukocyte transendothelial migration_Homo sapiens_hsa046701.29689691
76Retinol metabolism_Homo sapiens_hsa008301.26910644
77Phenylalanine metabolism_Homo sapiens_hsa003601.23918534
78Selenocompound metabolism_Homo sapiens_hsa004501.23459946
79Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23127236
80Non-small cell lung cancer_Homo sapiens_hsa052231.22272463
81Herpes simplex infection_Homo sapiens_hsa051681.22206269
82Fat digestion and absorption_Homo sapiens_hsa049751.21911873
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.20485483
84Pertussis_Homo sapiens_hsa051331.18740395
85TNF signaling pathway_Homo sapiens_hsa046681.17482321
86Folate biosynthesis_Homo sapiens_hsa007901.17110243
87Tyrosine metabolism_Homo sapiens_hsa003501.11916469
88Cysteine and methionine metabolism_Homo sapiens_hsa002701.09516528
89Hepatitis B_Homo sapiens_hsa051611.05321259
90Sulfur relay system_Homo sapiens_hsa041221.03422858
91Rheumatoid arthritis_Homo sapiens_hsa053231.02673697
92Staphylococcus aureus infection_Homo sapiens_hsa051501.01388697
93Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.01180243
94Arginine and proline metabolism_Homo sapiens_hsa003301.00765861
95Salmonella infection_Homo sapiens_hsa051320.97348707
96Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95495857
97ABC transporters_Homo sapiens_hsa020100.94629758
98Hepatitis C_Homo sapiens_hsa051600.94112073
99Shigellosis_Homo sapiens_hsa051310.93643443
100Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92330722
101Cyanoamino acid metabolism_Homo sapiens_hsa004600.92079727
102Fatty acid biosynthesis_Homo sapiens_hsa000610.91218946
103Pancreatic cancer_Homo sapiens_hsa052120.90846390
104Glycosaminoglycan degradation_Homo sapiens_hsa005310.89343165
105Lysosome_Homo sapiens_hsa041420.89274611
106Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.88599030
107SNARE interactions in vesicular transport_Homo sapiens_hsa041300.88159094
108Vitamin digestion and absorption_Homo sapiens_hsa049770.86916814
109Apoptosis_Homo sapiens_hsa042100.83665079
110Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82441624
111Glycerolipid metabolism_Homo sapiens_hsa005610.80011511
112VEGF signaling pathway_Homo sapiens_hsa043700.78958596
113Steroid biosynthesis_Homo sapiens_hsa001000.77977032
114Endocytosis_Homo sapiens_hsa041440.76749139
115Lysine degradation_Homo sapiens_hsa003100.76079813
116Chronic myeloid leukemia_Homo sapiens_hsa052200.74452985
117Maturity onset diabetes of the young_Homo sapiens_hsa049500.73851918
118Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73599319
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70601452
120Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70355451
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.70242275
122Glutathione metabolism_Homo sapiens_hsa004800.69320761
123Renal cell carcinoma_Homo sapiens_hsa052110.69320561
124Prolactin signaling pathway_Homo sapiens_hsa049170.67916888
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.67715045
126Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.65398766
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.64745152
128Dorso-ventral axis formation_Homo sapiens_hsa043200.63039587
129AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.61917198
130Pentose phosphate pathway_Homo sapiens_hsa000300.61144062
131Amoebiasis_Homo sapiens_hsa051460.60021502
132FoxO signaling pathway_Homo sapiens_hsa040680.58556493
133Regulation of autophagy_Homo sapiens_hsa041400.57110902
134Phospholipase D signaling pathway_Homo sapiens_hsa040720.54260044
135HIF-1 signaling pathway_Homo sapiens_hsa040660.52815256
136Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.51958770
137Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51942316
138Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49715522
139Epstein-Barr virus infection_Homo sapiens_hsa051690.49365443
140Galactose metabolism_Homo sapiens_hsa000520.47746043
141Choline metabolism in cancer_Homo sapiens_hsa052310.47469077
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.46978898
143Metabolic pathways_Homo sapiens_hsa011000.46487348
144Fructose and mannose metabolism_Homo sapiens_hsa000510.45370567
145Inositol phosphate metabolism_Homo sapiens_hsa005620.45114186
146Endometrial cancer_Homo sapiens_hsa052130.44493852
147GnRH signaling pathway_Homo sapiens_hsa049120.43986053
148Viral carcinogenesis_Homo sapiens_hsa052030.43503427
149Insulin resistance_Homo sapiens_hsa049310.43363150
150Vitamin B6 metabolism_Homo sapiens_hsa007500.39026168
151Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38828910
152mTOR signaling pathway_Homo sapiens_hsa041500.35813433
153Notch signaling pathway_Homo sapiens_hsa043300.35769118
154Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.33820222
155Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33247785
156Arachidonic acid metabolism_Homo sapiens_hsa005900.32700544
157Regulation of actin cytoskeleton_Homo sapiens_hsa048100.31980857
158MAPK signaling pathway_Homo sapiens_hsa040100.31098937
159Rap1 signaling pathway_Homo sapiens_hsa040150.30776063
160One carbon pool by folate_Homo sapiens_hsa006700.29983859
161Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.29686567
162Type II diabetes mellitus_Homo sapiens_hsa049300.27937723
163HTLV-I infection_Homo sapiens_hsa051660.27911481
164Glucagon signaling pathway_Homo sapiens_hsa049220.26230025
165AMPK signaling pathway_Homo sapiens_hsa041520.25776077
166Prion diseases_Homo sapiens_hsa050200.19447860
167Insulin signaling pathway_Homo sapiens_hsa049100.17085640
168alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.16352993
169Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.12442269
170Parkinsons disease_Homo sapiens_hsa050120.09476833
171Glycerophospholipid metabolism_Homo sapiens_hsa005640.08797707
172Cardiac muscle contraction_Homo sapiens_hsa042600.06654714
173Oxidative phosphorylation_Homo sapiens_hsa001900.05749050
174Central carbon metabolism in cancer_Homo sapiens_hsa052300.04488578
175Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.03126384
176Protein digestion and absorption_Homo sapiens_hsa049740.02741911
177Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.02544922
178Linoleic acid metabolism_Homo sapiens_hsa005910.02250307
179Dilated cardiomyopathy_Homo sapiens_hsa054140.02029168
180Thyroid hormone synthesis_Homo sapiens_hsa04918-0.0910681
181Mineral absorption_Homo sapiens_hsa04978-0.0709559
182Bladder cancer_Homo sapiens_hsa05219-0.0653114
183Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923-0.0486371
184Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0456774
185Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0418824
186Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.0406423
187Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.0377810
188Alzheimers disease_Homo sapiens_hsa05010-0.0215539
189Renin-angiotensin system_Homo sapiens_hsa04614-0.0191396
190Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0132016

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