CPQ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a metallopeptidase that belongs to the peptidase M28 family. The encoded protein may catalyze the cleavage of dipeptides with unsubstituted terminals into amino acids. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.74033978
2L-phenylalanine catabolic process (GO:0006559)5.74033978
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.41705728
4L-phenylalanine metabolic process (GO:0006558)5.41705728
5Golgi transport vesicle coating (GO:0048200)5.00110457
6COPI coating of Golgi vesicle (GO:0048205)5.00110457
7aromatic amino acid family catabolic process (GO:0009074)4.57281363
8neutrophil activation involved in immune response (GO:0002283)4.39464426
9sulfur amino acid catabolic process (GO:0000098)4.17838100
10complement activation, alternative pathway (GO:0006957)4.11997549
11triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.09960697
12signal peptide processing (GO:0006465)4.08259498
13maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.92187709
14peptidyl-glutamic acid carboxylation (GO:0017187)3.90134125
15protein carboxylation (GO:0018214)3.90134125
16alpha-linolenic acid metabolic process (GO:0036109)3.89367420
17valine metabolic process (GO:0006573)3.84799847
18glyoxylate metabolic process (GO:0046487)3.80359348
19bile acid biosynthetic process (GO:0006699)3.77844447
20fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.73309554
21detection of molecule of bacterial origin (GO:0032490)3.71442896
22antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.64573124
23protein retention in ER lumen (GO:0006621)3.60947289
24regulation of protein activation cascade (GO:2000257)3.58814788
25tryptophan catabolic process (GO:0006569)3.58723669
26indole-containing compound catabolic process (GO:0042436)3.58723669
27indolalkylamine catabolic process (GO:0046218)3.58723669
28tyrosine metabolic process (GO:0006570)3.56973321
29tryptophan metabolic process (GO:0006568)3.55472652
30* thyroid hormone generation (GO:0006590)3.55385876
31fatty acid beta-oxidation (GO:0006635)3.49203209
32regulation of complement activation (GO:0030449)3.46592848
33COPII vesicle coating (GO:0048208)3.46363020
34low-density lipoprotein particle remodeling (GO:0034374)3.46305422
35negative regulation of complement activation (GO:0045916)3.39712171
36cysteine metabolic process (GO:0006534)3.39287054
37high-density lipoprotein particle remodeling (GO:0034375)3.38821949
38negative regulation of fibrinolysis (GO:0051918)3.37017220
39regulation of fibrinolysis (GO:0051917)3.36592997
40regulation of cholesterol esterification (GO:0010872)3.36301832
41bile acid metabolic process (GO:0008206)3.35422836
42fatty acid oxidation (GO:0019395)3.31766741
43reverse cholesterol transport (GO:0043691)3.31378642
44lipid oxidation (GO:0034440)3.30891544
45kynurenine metabolic process (GO:0070189)3.28911621
46aromatic amino acid family metabolic process (GO:0009072)3.28090506
47cellular ketone body metabolic process (GO:0046950)3.25755891
48protein-lipid complex remodeling (GO:0034368)3.25508052
49macromolecular complex remodeling (GO:0034367)3.25508052
50plasma lipoprotein particle remodeling (GO:0034369)3.25508052
51lysine catabolic process (GO:0006554)3.24966116
52lysine metabolic process (GO:0006553)3.24966116
53macrophage activation involved in immune response (GO:0002281)3.24501058
54amino-acid betaine metabolic process (GO:0006577)3.23747902
55fatty acid catabolic process (GO:0009062)3.23591663
56drug transmembrane transport (GO:0006855)3.23501645
57negative regulation of cell killing (GO:0031342)3.18651709
58negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.18651709
59peptide hormone processing (GO:0016486)3.18473858
60homocysteine metabolic process (GO:0050667)3.18468421
61negative regulation of protein activation cascade (GO:2000258)3.17263585
62tricarboxylic acid metabolic process (GO:0072350)3.17188480
63short-chain fatty acid metabolic process (GO:0046459)3.12144799
64regulation of cholesterol metabolic process (GO:0090181)3.10847356
65cellular extravasation (GO:0045123)3.10618515
66urea cycle (GO:0000050)3.10205612
67urea metabolic process (GO:0019627)3.10205612
68phospholipid efflux (GO:0033700)3.09758183
69monocarboxylic acid catabolic process (GO:0072329)3.09523244
70retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.07481642
71positive regulation of gamma-delta T cell activation (GO:0046645)3.06000743
72modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.04912170
73positive regulation by organism of defense response of other organism involved in symbiotic interact3.04912170
74modulation by symbiont of host immune response (GO:0052553)3.04912170
75positive regulation by symbiont of host defense response (GO:0052509)3.04912170
76modulation by symbiont of host defense response (GO:0052031)3.04912170
77modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.04912170
78neutrophil activation (GO:0042119)3.04786991
79detection of external biotic stimulus (GO:0098581)3.04460015
80microglial cell activation (GO:0001774)3.03484785
81opsonization (GO:0008228)3.01735262
82regulation of cholesterol biosynthetic process (GO:0045540)3.00351975
83branched-chain amino acid metabolic process (GO:0009081)2.98167011
84sequestering of metal ion (GO:0051238)2.97394074
85bile acid and bile salt transport (GO:0015721)2.96050803
86regulation of plasminogen activation (GO:0010755)2.95352788
87regulation of triglyceride catabolic process (GO:0010896)2.94028425
88branched-chain amino acid catabolic process (GO:0009083)2.93894174
89* thyroid hormone metabolic process (GO:0042403)2.92971182
90acylglycerol homeostasis (GO:0055090)2.92543192
91triglyceride homeostasis (GO:0070328)2.92543192
92nitrogen cycle metabolic process (GO:0071941)2.92198159
93negative regulation of humoral immune response (GO:0002921)2.92115637
94macrophage activation (GO:0042116)2.90920333
95toxin metabolic process (GO:0009404)2.89738411
96alpha-amino acid catabolic process (GO:1901606)2.89660206
97urate metabolic process (GO:0046415)2.89091330
98positive regulation of cellular amide metabolic process (GO:0034250)2.89089650
99detection of other organism (GO:0098543)2.87842584
100granulocyte activation (GO:0036230)2.86756478
101coenzyme catabolic process (GO:0009109)2.84843250
102antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.84539626
103antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84539626
104endocrine pancreas development (GO:0031018)2.84271253
105cellular amino acid catabolic process (GO:0009063)2.82617037
106organic acid catabolic process (GO:0016054)2.81538904
107carboxylic acid catabolic process (GO:0046395)2.81538904
108negative regulation of interleukin-12 production (GO:0032695)2.80202848
109ketone body metabolic process (GO:1902224)2.79372011
110antigen processing and presentation of endogenous antigen (GO:0019883)2.78541994
111amine catabolic process (GO:0009310)2.77864199
112cellular biogenic amine catabolic process (GO:0042402)2.77864199
113cellular modified amino acid catabolic process (GO:0042219)2.77382170
1142-oxoglutarate metabolic process (GO:0006103)2.74927606
115indolalkylamine metabolic process (GO:0006586)2.74247670
116response to peptidoglycan (GO:0032494)2.74028345
117plasma lipoprotein particle clearance (GO:0034381)2.73446241
118regulation of B cell receptor signaling pathway (GO:0050855)2.71408379
119lipoprotein metabolic process (GO:0042157)2.70716228
120drug transport (GO:0015893)2.70086001
121carnitine metabolic process (GO:0009437)2.70074204
122regulation of interferon-beta biosynthetic process (GO:0045357)2.68619597
123ethanol oxidation (GO:0006069)2.68128186
124blood coagulation, intrinsic pathway (GO:0007597)2.66701005
125negative regulation of digestive system process (GO:0060457)2.65323172
126plasma lipoprotein particle organization (GO:0071827)2.65267028
127keratan sulfate catabolic process (GO:0042340)2.64799948
128drug metabolic process (GO:0017144)2.64166660
129positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.64117640
130positive regulation of glycolytic process (GO:0045821)2.64116830
131protein activation cascade (GO:0072376)2.64085285
132detection of biotic stimulus (GO:0009595)2.60562721
133detection of bacterium (GO:0016045)2.56360143
134myeloid cell activation involved in immune response (GO:0002275)2.51531003
135regulation of gamma-delta T cell activation (GO:0046643)2.48312619
136cellular response to ethanol (GO:0071361)2.47864079
137oxygen transport (GO:0015671)2.47121600
138immunoglobulin mediated immune response (GO:0016064)2.46479757
139positive regulation of mast cell activation (GO:0033005)2.42050648
140xenobiotic catabolic process (GO:0042178)2.40607054
141regulation of mast cell activation involved in immune response (GO:0033006)2.40399230
142regulation of mast cell degranulation (GO:0043304)2.36481041
143regulation of mast cell activation (GO:0033003)2.36409270
144production of molecular mediator involved in inflammatory response (GO:0002532)2.35588362
145cellular response to zinc ion (GO:0071294)2.33287232
146lipopolysaccharide-mediated signaling pathway (GO:0031663)2.32871478
147leukocyte migration involved in inflammatory response (GO:0002523)2.31073515
148positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.26693008
149type I interferon signaling pathway (GO:0060337)2.26173426
150cellular response to type I interferon (GO:0071357)2.26173426
151response to type I interferon (GO:0034340)2.25899815
152regulation of platelet activation (GO:0010543)2.24401774
153negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.22568787
154neutrophil mediated immunity (GO:0002446)2.22321191
155regulation of myeloid leukocyte mediated immunity (GO:0002886)2.21569255
156response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.20375607
157response to host immune response (GO:0052572)2.20375607
158regulation of platelet aggregation (GO:0090330)2.20241488
159positive regulation of mast cell activation involved in immune response (GO:0033008)2.19195872
160positive regulation of mast cell degranulation (GO:0043306)2.19195872
161negative regulation of T-helper cell differentiation (GO:0045623)2.18475712
162negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.18475712
163regulation of gamma-delta T cell differentiation (GO:0045586)2.18441479
164positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.17730152
165negative regulation of interleukin-8 production (GO:0032717)2.17277295
166interferon-gamma-mediated signaling pathway (GO:0060333)2.16806343
167positive regulation of toll-like receptor signaling pathway (GO:0034123)2.16318560
168positive regulation of receptor recycling (GO:0001921)2.14065867
169regulation of T-helper 2 cell differentiation (GO:0045628)2.13931591
170positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.13771788
171regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.13030598
172cellular response to thyroid hormone stimulus (GO:0097067)2.12875398
173negative regulation of lymphocyte mediated immunity (GO:0002707)2.12020983
174positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.10112878
175regulation of antigen processing and presentation (GO:0002577)2.08799522
176interleukin-6-mediated signaling pathway (GO:0070102)2.08478058
177regulation of leukocyte degranulation (GO:0043300)2.07495196
178positive regulation of blood coagulation (GO:0030194)2.06945339
179positive regulation of hemostasis (GO:1900048)2.06945339
180regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.06846862
181T-helper 1 type immune response (GO:0042088)2.06786332
182positive regulation of coagulation (GO:0050820)2.05899786
183dendritic cell migration (GO:0036336)2.05786840
184myeloid leukocyte activation (GO:0002274)2.05031188
185phagocytosis, engulfment (GO:0006911)2.04678089
186neutrophil chemotaxis (GO:0030593)2.03699140
187superoxide anion generation (GO:0042554)2.02643203
188germinal center formation (GO:0002467)2.02067718
189angiogenesis involved in wound healing (GO:0060055)2.01638755
190positive regulation of tumor necrosis factor production (GO:0032760)1.99864612
191neutrophil migration (GO:1990266)1.98792173
192positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)1.97626888
193negative regulation of amyloid precursor protein catabolic process (GO:1902992)1.97322139
194response to defenses of other organism involved in symbiotic interaction (GO:0052173)1.97198163
195response to host defenses (GO:0052200)1.97198163

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.32326409
2RXR_22158963_ChIP-Seq_LIVER_Mouse6.15229406
3PPARA_22158963_ChIP-Seq_LIVER_Mouse5.14101596
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.93684988
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.71172988
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.17791048
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.95265804
8FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.62883784
9GATA1_22025678_ChIP-Seq_K562_Human3.61118825
10FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.59669531
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.37125259
12FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.24431334
13IRF8_22096565_ChIP-ChIP_GC-B_Human3.15497866
14IRF8_21731497_ChIP-ChIP_J774_Mouse2.82954047
15SMAD_19615063_ChIP-ChIP_OVARY_Human2.65899466
16NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.63984037
17STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.62209645
18TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.32058601
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.09939968
20BP1_19119308_ChIP-ChIP_Hs578T_Human2.07732991
21CLOCK_20551151_ChIP-Seq_293T_Human2.04733291
22PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.91509041
23TRIM28_21343339_ChIP-Seq_HEK293_Human1.78118534
24VDR_24787735_ChIP-Seq_THP-1_Human1.77644859
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.74263272
26HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.70228190
27STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.67899392
28ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.66230692
29RUNX_20019798_ChIP-Seq_JUKART_Human1.64855239
30SPI1_23127762_ChIP-Seq_K562_Human1.62082505
31RARG_19884340_ChIP-ChIP_MEFs_Mouse1.61482558
32LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.56707154
33GBX2_23144817_ChIP-Seq_PC3_Human1.56174548
34PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.55437326
35SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.51992913
36TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.45504429
37SCL_19346495_ChIP-Seq_HPC-7_Human1.44550805
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40027458
39GATA2_21666600_ChIP-Seq_HMVEC_Human1.38280580
40SOX2_27498859_Chip-Seq_STOMACH_Mouse1.36072167
41IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32261521
42RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.30811955
43SOX2_20726797_ChIP-Seq_SW620_Human1.25108102
44AR_20517297_ChIP-Seq_VCAP_Human1.25075863
45GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.24305183
46GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.23992519
47CJUN_26792858_Chip-Seq_BT549_Human1.22128115
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.20687960
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.20046352
50ESR1_21235772_ChIP-Seq_MCF-7_Human1.17590654
51PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.17446130
52ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17210397
53FOXA2_19822575_ChIP-Seq_HepG2_Human1.17176414
54TP53_16413492_ChIP-PET_HCT116_Human1.17064663
55GATA4_25053715_ChIP-Seq_YYC3_Human1.16207392
56VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.16162797
57BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.15119643
58NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14349698
59NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14349698
60FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.13439184
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13046338
62ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.12934984
63LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.11373686
64TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.10573115
65JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09371963
66CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09314512
67ZNF217_24962896_ChIP-Seq_MCF-7_Human1.07952052
68EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.07086467
69SRF_21415370_ChIP-Seq_HL-1_Mouse1.05344988
70STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.03776547
71HTT_18923047_ChIP-ChIP_STHdh_Human1.03418105
72PIAS1_25552417_ChIP-Seq_VCAP_Human1.02679461
73FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.02375013
74Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01936433
75BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.99959324
76JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.99632557
77AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.99040429
78MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.98577273
79PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.97741333
80THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.97384637
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.96615709
82FOXA1_25552417_ChIP-Seq_VCAP_Human0.96165480
83HNF4A_19822575_ChIP-Seq_HepG2_Human0.95994021
84RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.95140727
85ERG_20517297_ChIP-Seq_VCAP_Human0.94467139
86ERG_20887958_ChIP-Seq_HPC-7_Mouse0.93809191
87SUZ12_27294783_Chip-Seq_NPCs_Mouse0.93245517
88ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.93082404
89EZH2_27294783_Chip-Seq_NPCs_Mouse0.92924554
90FOXO3_23340844_ChIP-Seq_DLD1_Human0.92656051
91POU3F2_20337985_ChIP-ChIP_501MEL_Human0.91470071
92PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.91220668
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90197263
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.89707221
95SALL4_18804426_ChIP-ChIP_XEN_Mouse0.89357499
96CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.88639307
97MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88637349
98* SPI1_23547873_ChIP-Seq_NB4_Human0.88506404
99GATA3_27048872_Chip-Seq_THYMUS_Human0.88129598
100IKZF1_21737484_ChIP-ChIP_HCT116_Human0.87586438
101TP63_23658742_ChIP-Seq_EP156T_Human0.85626459
102NFE2_27457419_Chip-Seq_LIVER_Mouse0.84957862
103SMAD4_21799915_ChIP-Seq_A2780_Human0.84299402
104GATA1_19941826_ChIP-Seq_K562_Human0.83776123
105NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.83413804
106ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.82977409
107MYB_26560356_Chip-Seq_TH2_Human0.82722567
108PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.82394945
109SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.82106505
110CDX2_22108803_ChIP-Seq_LS180_Human0.81254973
111GATA1_22383799_ChIP-Seq_G1ME_Mouse0.81107116
112SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.81087730
113PU_27001747_Chip-Seq_BMDM_Mouse0.80155794
114SMRT_27268052_Chip-Seq_Bcells_Human0.80064889
115STAT4_19710469_ChIP-ChIP_TH1__Mouse0.79684198
116VDR_24763502_ChIP-Seq_THP-1_Human0.79453796
117DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.79397675
118OCT4_21477851_ChIP-Seq_ESCs_Mouse0.78957960
119ESR1_20079471_ChIP-ChIP_T-47D_Human0.78267200
120CRX_20693478_ChIP-Seq_RETINA_Mouse0.77792091
121BRD4_27068464_Chip-Seq_AML-cells_Mouse0.76646589
122PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.76035705
123PRDM14_20953172_ChIP-Seq_ESCs_Human0.75902085
124DROSHA_22980978_ChIP-Seq_HELA_Human0.75431781
125CDX2_19796622_ChIP-Seq_MESCs_Mouse0.74597961
126CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.74198266
127IRF8_27001747_Chip-Seq_BMDM_Mouse0.73734129
128RXRA_24833708_ChIP-Seq_LIVER_Mouse0.71618736
129CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.70851348
130PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.70729323
131EP300_21415370_ChIP-Seq_HL-1_Mouse0.70018915
132RAD21_21589869_ChIP-Seq_MESCs_Mouse0.69179597
133GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.68737438
134PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.66407815
135CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.65830084
136TBX20_22080862_ChIP-Seq_HEART_Mouse0.65050913
137TBX20_22328084_ChIP-Seq_HEART_Mouse0.65050913
138ESR2_21235772_ChIP-Seq_MCF-7_Human0.64706494
139NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.64525776
140GATA2_22383799_ChIP-Seq_G1ME_Mouse0.62416906
141GATA1_19941827_ChIP-Seq_MEL_Mouse0.61828060
142GATA3_24758297_ChIP-Seq_MCF-7_Human0.61465277
143MYB_21317192_ChIP-Seq_ERMYB_Mouse0.61038654
144SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.60694499
145VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.60564073
146GATA3_26560356_Chip-Seq_TH2_Human0.60541183
147BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.58999300
148BCAT_22108803_ChIP-Seq_LS180_Human0.58884234
149SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.58701615
150PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.58640327
151PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.58228698
152GATA2_19941826_ChIP-Seq_K562_Human0.58139649
153TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.58135603

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.26033374
2MP0005365_abnormal_bile_salt4.59532008
3MP0005360_urolithiasis4.22930918
4MP0005085_abnormal_gallbladder_physiolo3.81161155
5MP0003195_calcinosis3.80233715
6MP0008875_abnormal_xenobiotic_pharmacok3.23809079
7MP0003252_abnormal_bile_duct2.88784458
8MP0003806_abnormal_nucleotide_metabolis2.73054479
9MP0006082_CNS_inflammation2.65218771
10MP0010329_abnormal_lipoprotein_level2.48205910
11MP0003303_peritoneal_inflammation2.44847788
12MP0003183_abnormal_peptide_metabolism2.41166768
13MP0005332_abnormal_amino_acid2.37207563
14MP0009840_abnormal_foam_cell2.32144832
15MP0002138_abnormal_hepatobiliary_system2.30881368
16MP0003436_decreased_susceptibility_to2.30174311
17MP0000013_abnormal_adipose_tissue2.28380748
18MP0004043_abnormal_pH_regulation2.25487423
19MP0002837_dystrophic_cardiac_calcinosis2.08278092
20MP0002419_abnormal_innate_immunity2.07391094
21MP0009785_altered_susceptibility_to2.06337447
22MP0001666_abnormal_nutrient_absorption2.03436615
23MP0009643_abnormal_urine_homeostasis1.98485711
24MP0005379_endocrine/exocrine_gland_phen1.97961353
25MP0003868_abnormal_feces_composition1.96137468
26MP0003191_abnormal_cellular_cholesterol1.94709677
27MP0000569_abnormal_digit_pigmentation1.93645354
28MP0002877_abnormal_melanocyte_morpholog1.89281728
29MP0002148_abnormal_hypersensitivity_rea1.87516676
30MP0001533_abnormal_skeleton_physiology1.86807757
31MP0004019_abnormal_vitamin_homeostasis1.84713422
32MP0005058_abnormal_lysosome_morphology1.80594339
33MP0005220_abnormal_exocrine_pancreas1.78327057
34MP0001958_emphysema1.77434063
35MP0008438_abnormal_cutaneous_collagen1.74715983
36MP0005025_abnormal_response_to1.72158537
37MP0002118_abnormal_lipid_homeostasis1.71689232
38MP0005387_immune_system_phenotype1.69227778
39MP0001790_abnormal_immune_system1.69227778
40MP0000678_abnormal_parathyroid_gland1.67420630
41MP0005000_abnormal_immune_tolerance1.63751157
42MP0005083_abnormal_biliary_tract1.63187086
43MP0001944_abnormal_pancreas_morphology1.62492612
44MP0000343_altered_response_to1.59274748
45MP0005084_abnormal_gallbladder_morpholo1.58272044
46MP0005319_abnormal_enzyme/_coenzyme1.58146183
47MP0005670_abnormal_white_adipose1.57766820
48MP0000609_abnormal_liver_physiology1.57690592
49MP0002693_abnormal_pancreas_physiology1.52215141
50MP0005164_abnormal_response_to1.50968244
51MP0002909_abnormal_adrenal_gland1.49666425
52MP0000604_amyloidosis1.49223459
53MP0001756_abnormal_urination1.49068412
54MP0003075_altered_response_to1.48952486
55MP0010386_abnormal_urinary_bladder1.48868784
56MP0004883_abnormal_blood_vessel1.47974950
57MP0005636_abnormal_mineral_homeostasis1.46246433
58MP0001764_abnormal_homeostasis1.45211497
59MP0003045_fibrosis1.45040991
60MP0006054_spinal_hemorrhage1.42568459
61MP0002078_abnormal_glucose_homeostasis1.41322075
62MP0002723_abnormal_immune_serum1.40826218
63MP0005584_abnormal_enzyme/coenzyme_acti1.39611945
64MP0003724_increased_susceptibility_to1.39321964
65MP0002452_abnormal_antigen_presenting1.38455946
66MP0001800_abnormal_humoral_immune1.38094011
67MP0003186_abnormal_redox_activity1.37866348
68MP0003828_pulmonary_edema1.37049658
69MP0002998_abnormal_bone_remodeling1.36286406
70MP0001845_abnormal_inflammatory_respons1.35172181
71MP0005167_abnormal_blood-brain_barrier1.34549883
72MP0000681_abnormal_thyroid_gland1.34067079
73MP0008004_abnormal_stomach_pH1.32308299
74MP0010368_abnormal_lymphatic_system1.30968840
75MP0003172_abnormal_lysosome_physiology1.30381464
76MP0005671_abnormal_response_to1.25612224
77MP0002876_abnormal_thyroid_physiology1.24853609
78MP0003656_abnormal_erythrocyte_physiolo1.22158405
79MP0009697_abnormal_copulation1.21197116
80MP0002420_abnormal_adaptive_immunity1.16986907
81MP0001819_abnormal_immune_cell1.15746763
82MP0009780_abnormal_chondrocyte_physiolo1.15544423
83MP0000003_abnormal_adipose_tissue1.13860581
84MP0008260_abnormal_autophagy1.09895963
85MP0010155_abnormal_intestine_physiology1.09762152
86MP0000230_abnormal_systemic_arterial1.09731637
87MP0002405_respiratory_system_inflammati1.07580167
88MP0002132_abnormal_respiratory_system1.07085234
89MP0006036_abnormal_mitochondrial_physio1.06804601
90MP0008469_abnormal_protein_level1.06598636
91MP0001542_abnormal_bone_strength1.05122872
92MP0000465_gastrointestinal_hemorrhage1.04984769
93MP0001765_abnormal_ion_homeostasis1.04912265
94MP0005310_abnormal_salivary_gland1.03358405
95MP0003300_gastrointestinal_ulcer1.02355934
96MP0004510_myositis1.02175306
97MP0004147_increased_porphyrin_level0.98741598
98MP0004264_abnormal_extraembryonic_tissu0.98684708
99MP0009642_abnormal_blood_homeostasis0.98287341
100MP0002928_abnormal_bile_duct0.96553833
101MP0000249_abnormal_blood_vessel0.96519294
102MP0005390_skeleton_phenotype0.95457389
103MP0005397_hematopoietic_system_phenotyp0.93895154
104MP0001545_abnormal_hematopoietic_system0.93895154
105MP0001986_abnormal_taste_sensitivity0.93004376
106MP0004130_abnormal_muscle_cell0.92597242
107MP0005166_decreased_susceptibility_to0.90170984
108MP0002933_joint_inflammation0.90083243
109MP0001851_eye_inflammation0.89495930
110MP0004782_abnormal_surfactant_physiolog0.89060818
111MP0000598_abnormal_liver_morphology0.88802652
112MP0009764_decreased_sensitivity_to0.88395114
113MP0004947_skin_inflammation0.87850913
114MP0009384_cardiac_valve_regurgitation0.87278164
115MP0005595_abnormal_vascular_smooth0.87274564
116MP0003953_abnormal_hormone_level0.86978559
117MP0003329_amyloid_beta_deposits0.86442764
118MP0005408_hypopigmentation0.86044850
119MP0003879_abnormal_hair_cell0.85178479
120MP0000015_abnormal_ear_pigmentation0.85124718
121MP0001501_abnormal_sleep_pattern0.83897483
122MP0003011_delayed_dark_adaptation0.83265650
123MP0005334_abnormal_fat_pad0.82555937
124MP0000920_abnormal_myelination0.82174183
125MP0000639_abnormal_adrenal_gland0.82059017
126MP0003959_abnormal_lean_body0.81583889
127MP0005503_abnormal_tendon_morphology0.80620392
128MP0005275_abnormal_skin_tensile0.80601462
129MP0005174_abnormal_tail_pigmentation0.79707460
130MP0003866_abnormal_defecation0.79148470
131MP0009763_increased_sensitivity_to0.78778503
132MP0002136_abnormal_kidney_physiology0.78729023
133MP0001879_abnormal_lymphatic_vessel0.78624737
134MP0005171_absent_coat_pigmentation0.78111055
135MP0005375_adipose_tissue_phenotype0.77224657
136MP0001270_distended_abdomen0.77137368
137MP0001661_extended_life_span0.76990219
138MP0000685_abnormal_immune_system0.76149614
139MP0005535_abnormal_body_temperature0.75838099
140MP0003795_abnormal_bone_structure0.74502418
141MP0002295_abnormal_pulmonary_circulatio0.73789557
142MP0003279_aneurysm0.73733989
143MP0000371_diluted_coat_color0.73299776
144MP0005451_abnormal_body_composition0.73117178
145MP0003690_abnormal_glial_cell0.72632103
146MP0002254_reproductive_system_inflammat0.72453738
147MP0005464_abnormal_platelet_physiology0.70517906
148MP0002896_abnormal_bone_mineralization0.69065910
149MP0002060_abnormal_skin_morphology0.67364125
150MP0005666_abnormal_adipose_tissue0.65700434
151MP0004272_abnormal_basement_membrane0.65160594
152MP0002168_other_aberrant_phenotype0.64787990
153MP0001835_abnormal_antigen_presentation0.64647595
154MP0002166_altered_tumor_susceptibility0.64140928
155MP0000613_abnormal_salivary_gland0.63729805
156MP0001853_heart_inflammation0.62205628
157MP0003638_abnormal_response/metabolism_0.61757366
158MP0005448_abnormal_energy_balance0.61695084
159MP0002971_abnormal_brown_adipose0.60395279

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of aromatic amino acid family metabolism (HP:0004338)5.92972912
2Hypoglycemic coma (HP:0001325)5.68229145
3Hypoglycemic seizures (HP:0002173)4.48342601
4Intrahepatic cholestasis (HP:0001406)4.45312567
5Ketoacidosis (HP:0001993)4.44549507
6Hyperinsulinemic hypoglycemia (HP:0000825)4.32851763
7Generalized aminoaciduria (HP:0002909)4.26109223
8Eczematoid dermatitis (HP:0000976)4.08389055
9Abnormality of liposaccharide metabolism (HP:0010968)4.08041677
10Abnormality of glycosphingolipid metabolism (HP:0004343)4.08041677
11Abnormality of glycolipid metabolism (HP:0010969)4.08041677
12Ketosis (HP:0001946)3.98363195
13Prolonged partial thromboplastin time (HP:0003645)3.97075080
14Abnormality of the intrinsic pathway (HP:0010989)3.92973585
15Abnormality of monocarboxylic acid metabolism (HP:0010996)3.90626622
16Xanthomatosis (HP:0000991)3.84369855
17Orchitis (HP:0100796)3.79209739
18Abnormality of macrophages (HP:0004311)3.77252119
19Late onset (HP:0003584)3.72420732
20Deep venous thrombosis (HP:0002625)3.72079880
21Myositis (HP:0100614)3.67927148
22Symptomatic seizures (HP:0011145)3.67054285
23Complement deficiency (HP:0004431)3.65312514
24Retrobulbar optic neuritis (HP:0100654)3.61693844
25Optic neuritis (HP:0100653)3.61693844
26Recurrent abscess formation (HP:0002722)3.56181418
27Recurrent bacterial skin infections (HP:0005406)3.51844341
28Stomatitis (HP:0010280)3.51796224
29Hyperlipoproteinemia (HP:0010980)3.48745758
30Abnormality of the common coagulation pathway (HP:0010990)3.46793402
31Gingival bleeding (HP:0000225)3.41844722
32Conjugated hyperbilirubinemia (HP:0002908)3.39126584
33Abnormality of fatty-acid metabolism (HP:0004359)3.36866982
34Prolonged bleeding time (HP:0003010)3.31851038
35Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.24363170
36Spontaneous hematomas (HP:0007420)3.21175829
37Hyperglycemia (HP:0003074)3.15385033
38Purpura (HP:0000979)3.08582409
39Peritonitis (HP:0002586)3.00063866
40Loss of speech (HP:0002371)2.99616893
41Mucopolysacchariduria (HP:0008155)2.99005189
42Urinary glycosaminoglycan excretion (HP:0003541)2.99005189
43Hematochezia (HP:0002573)2.95046197
44Joint hemorrhage (HP:0005261)2.95016452
45Large for gestational age (HP:0001520)2.87225030
46Abnormality of endocrine pancreas physiology (HP:0012093)2.84994508
47Abnormality of the pancreatic islet cells (HP:0006476)2.84994508
48Hyperammonemia (HP:0001987)2.84197100
49Vacuolated lymphocytes (HP:0001922)2.80744707
50Pancreatic islet-cell hyperplasia (HP:0004510)2.80730438
51Increased CSF protein (HP:0002922)2.80435876
52Fat malabsorption (HP:0002630)2.79614748
53Dysostosis multiplex (HP:0000943)2.79024303
54Epistaxis (HP:0000421)2.78531644
55Hyperglycinuria (HP:0003108)2.77272746
56Amyloidosis (HP:0011034)2.75753952
57Increased cerebral lipofuscin (HP:0011813)2.74110413
58Episodic fever (HP:0001954)2.73586618
59Hyperbilirubinemia (HP:0002904)2.71648807
60Dicarboxylic aciduria (HP:0003215)2.71455055
61Abnormality of dicarboxylic acid metabolism (HP:0010995)2.71455055
62Abnormality of polysaccharide metabolism (HP:0011012)2.70126750
63Abnormality of glycosaminoglycan metabolism (HP:0004371)2.70126750
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.70126750
65Hypobetalipoproteinemia (HP:0003563)2.69897015
66Elevated erythrocyte sedimentation rate (HP:0003565)2.69676881
67Abnormality of complement system (HP:0005339)2.65562692
68Elevated circulating parathyroid hormone (PTH) level (HP:0003165)2.62823113
69Epidermoid cyst (HP:0200040)2.58875551
70Abnormality of glutamine family amino acid metabolism (HP:0010902)2.58701143
71Keratoconjunctivitis sicca (HP:0001097)2.54241073
72Petechiae (HP:0000967)2.53267982
73Keratoconjunctivitis (HP:0001096)2.47466228
74Gastrointestinal infarctions (HP:0005244)2.43598073
75Gingivitis (HP:0000230)2.41034550
76Hemoptysis (HP:0002105)2.40178135
77Systemic lupus erythematosus (HP:0002725)2.39148127
78Abnormality of serine family amino acid metabolism (HP:0010894)2.38701663
79Abnormality of glycine metabolism (HP:0010895)2.38701663
80Insulin-resistant diabetes mellitus (HP:0000831)2.38325983
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.37407944
82Skin nodule (HP:0200036)2.36889701
83Proximal tubulopathy (HP:0000114)2.34985350
84Pulmonary embolism (HP:0002204)2.34760021
85Hyperglycinemia (HP:0002154)2.33905169
86Pulmonary infiltrates (HP:0002113)2.33860898
87Abnormality of aspartate family amino acid metabolism (HP:0010899)2.32321284
88Abnormality of methionine metabolism (HP:0010901)2.32275526
89Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.32178065
90Recurrent skin infections (HP:0001581)2.32085064
91Hypolipoproteinemia (HP:0010981)2.30491505
92Hypoalphalipoproteinemia (HP:0003233)2.30182360
93Metabolic acidosis (HP:0001942)2.27750077
94Hypothermia (HP:0002045)2.27067285
95Delayed CNS myelination (HP:0002188)2.27019983
96Arthropathy (HP:0003040)2.25185754
97Abnormality of sulfur amino acid metabolism (HP:0004339)2.24472454
98Gout (HP:0001997)2.19426119
99Abnormal hemoglobin (HP:0011902)2.19419592
100Abnormality of purine metabolism (HP:0004352)2.19353172
101Abnormality of urine glucose concentration (HP:0011016)2.18599694
102Glycosuria (HP:0003076)2.18599694
103Arterial thrombosis (HP:0004420)2.17222426
104Congenital sensorineural hearing impairment (HP:0008527)2.16802526
105Mitral stenosis (HP:0001718)2.16114189
106Insulin resistance (HP:0000855)2.12097937
107Abnormality of calcium-phosphate metabolism (HP:0100530)2.10567536
108Beaking of vertebral bodies (HP:0004568)2.09334032
109Cerebral palsy (HP:0100021)2.07659929
110Vasculitis (HP:0002633)2.07362721
111Steatorrhea (HP:0002570)2.07105540
112Pancreatitis (HP:0001733)2.06231212
113Progressive neurologic deterioration (HP:0002344)2.04429580
114Goiter (HP:0000853)2.04146916
115Aortic aneurysm (HP:0004942)2.04024686
116Abnormal platelet volume (HP:0011876)2.02042750
117Reduced antithrombin III activity (HP:0001976)2.01405058
118Hypercholesterolemia (HP:0003124)2.01288593
119Hypochromic microcytic anemia (HP:0004840)2.01030287
120Joint swelling (HP:0001386)2.00832006
121Renal cortical cysts (HP:0000803)2.00563111
122Acne (HP:0001061)1.98910532
123Irritability (HP:0000737)1.98027604
124Abnormality of the vasculature of the conjunctiva (HP:0008054)1.97771078
125Nephritis (HP:0000123)1.97016983
126Glomerulonephritis (HP:0000099)1.96086350
127Recurrent fungal infections (HP:0002841)1.95383798
128Abnormality of T cell number (HP:0011839)1.95226442
129Chronic obstructive pulmonary disease (HP:0006510)1.94789041
130Obstructive lung disease (HP:0006536)1.94789041
131Myocardial infarction (HP:0001658)1.93332574
132Hepatic necrosis (HP:0002605)1.93242101
133Retinal atrophy (HP:0001105)1.92588493
134Recurrent gram-negative bacterial infections (HP:0005420)1.91824967
135Abnormality of nucleobase metabolism (HP:0010932)1.91603697
136T lymphocytopenia (HP:0005403)1.91146435
137Mediastinal lymphadenopathy (HP:0100721)1.90752075
138Spondylolisthesis (HP:0003302)1.90327899
139Bruising susceptibility (HP:0000978)1.89017855
140Polycythemia (HP:0001901)1.88988860
141Enlarged kidneys (HP:0000105)1.88254119
142Abnormality of the pericardium (HP:0001697)1.88237571
143Hypophosphatemia (HP:0002148)1.87495168
144Albinism (HP:0001022)1.87084695
145Asymmetric septal hypertrophy (HP:0001670)1.84977625
146Lethargy (HP:0001254)1.84937290
147Increased mean platelet volume (HP:0011877)1.83995760
148Protrusio acetabuli (HP:0003179)1.81891121
149Aortic dissection (HP:0002647)1.81212620
150Protuberant abdomen (HP:0001538)1.80994284
151Bone cyst (HP:0012062)1.80605274
152Growth hormone excess (HP:0000845)1.79640634
153Cervical subluxation (HP:0003308)1.78735255
154Abnormality of iron homeostasis (HP:0011031)1.78050643
155Gangrene (HP:0100758)1.77119514
156Alkalosis (HP:0001948)1.76643347
157Chest pain (HP:0100749)1.76576830
158Microcytic anemia (HP:0001935)1.75630870
159Hyperphosphatemia (HP:0002905)1.75256408
160Menorrhagia (HP:0000132)1.75078865
161Nausea (HP:0002018)1.74005419
162Conjunctival telangiectasia (HP:0000524)1.73793487
163Vomiting (HP:0002013)1.73537053
164Abnormal protein glycosylation (HP:0012346)1.73474861
165Abnormal glycosylation (HP:0012345)1.73474861
166Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.73474861
167Abnormal protein N-linked glycosylation (HP:0012347)1.73474861
168Hydroxyprolinuria (HP:0003080)1.73462530
169Abnormality of proline metabolism (HP:0010907)1.73462530
170Basal ganglia calcification (HP:0002135)1.73119474
171Vertigo (HP:0002321)1.72224438
172Nuclear cataract (HP:0100018)1.71676343
173Encephalitis (HP:0002383)1.71255356
174Malnutrition (HP:0004395)1.70249383
175Cardiovascular calcification (HP:0011915)1.67685513
176Vascular tortuosity (HP:0004948)1.66294742
177Leukocytosis (HP:0001974)1.66207303
178Urticaria (HP:0001025)1.65747806
179Neurofibrillary tangles (HP:0002185)1.65608038
180Anorexia (HP:0002039)1.64949603

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR4.71478148
2MAPK154.68459181
3BCKDK3.80592366
4ERN13.57648397
5PIK3CG3.51908707
6TAOK33.31044358
7FRK3.23220245
8RIPK43.07030609
9BLK2.69751595
10FLT32.62242416
11WNK32.60480596
12WNK42.20375948
13SIK12.10124089
14TNIK1.84512792
15TIE11.82899662
16PRKD31.80173984
17TGFBR21.75175020
18IRAK31.66889129
19ACVR1B1.65140160
20FGFR41.58431331
21BMPR21.55311444
22TXK1.55063786
23EPHA31.53227452
24GRK61.52627245
25TRIB31.51561184
26KIT1.47861786
27TEC1.41644913
28MYLK1.38634789
29PTK2B1.34091264
30FES1.31607088
31DAPK21.31469509
32PASK1.27170262
33TNK21.26520886
34FGFR31.24990557
35STK161.22103873
36SYK1.18911236
37FGR1.17380524
38MAP4K11.14509270
39TYK21.13520120
40HIPK21.11869738
41CAMKK21.11224344
42MUSK1.09754129
43PRKG21.09584365
44DDR21.08949217
45IRAK41.06555879
46BTK1.06540493
47MAP3K131.06361541
48FER1.03710352
49HCK1.02374664
50PTK61.01901479
51PINK11.00745732
52MAP2K30.99906687
53IRAK10.99399396
54NUAK10.97792684
55ZAP700.94848873
56TBK10.93969307
57CDC42BPA0.93384532
58KDR0.89795154
59MAP3K20.89194806
60JAK30.86958476
61JAK10.84186642
62NEK90.83702275
63MAP3K10.83558757
64NLK0.82901042
65BRSK20.82848305
66DYRK1B0.82532441
67MAPK70.82240194
68YES10.80293141
69PRKAA20.80128845
70TAOK10.80117636
71RIPK10.77990922
72MAP3K120.77008422
73TGFBR10.76593112
74PDK10.75031181
75EIF2AK30.73297959
76ADRBK10.72778183
77LCK0.72493972
78JAK20.72237828
79PDGFRB0.71619909
80BMPR1B0.71131804
81PDPK10.71013889
82MOS0.69880261
83MAPK110.67726060
84IKBKE0.67364545
85MARK30.67356532
86CDK80.66746649
87KSR20.66135021
88PKN20.66130681
89SGK20.65219735
90PDGFRA0.64153250
91PIK3CA0.63528656
92LMTK20.62535317
93MST1R0.61952010
94NME20.61319400
95MAPKAPK50.61182634
96PTK20.60649710
97SCYL20.60083717
98EPHB10.59981049
99NTRK30.59878988
100PRKD10.59077663
101MAP3K50.57798644
102STK240.56754267
103SGK30.56562563
104MAP3K110.55187621
105MAP3K60.54406998
106PIM20.53931372
107MAP3K140.53789278
108MAP3K30.53757828
109MAPK120.52471665
110GRK10.52191004
111GRK50.51926285
112IGF1R0.51379628
113STK380.50287006
114PRKD20.49731484
115CSK0.48510867
116TRPM70.47547359
117UHMK10.47516438
118IRAK20.47465280
119AKT30.46532249
120DMPK0.44826487
121PRKCQ0.44390122
122MAP4K20.43031515
123MET0.42876080
124PRKAA10.42688297
125MAP2K60.42528063
126CAMK1D0.42342359
127ADRBK20.42199439
128PRKCH0.40966422
129STK38L0.38296901
130LYN0.35623706
131MATK0.35507490
132PRKACG0.33529193
133CHUK0.33152852
134ZAK0.30825601
135PAK30.30777660
136GSK3A0.29187092
137MAP3K70.28758983
138CSF1R0.28651386
139ABL20.27663753
140ITK0.27485117
141RET0.26508452
142NTRK10.25984953
143PRKCE0.25449753
144PHKG20.25126492
145PHKG10.25126492
146WNK10.23543272
147IKBKB0.23183691
148GRK70.22268799

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049504.13244301
2Primary bile acid biosynthesis_Homo sapiens_hsa001203.31555963
3Sulfur metabolism_Homo sapiens_hsa009202.84657009
4Protein export_Homo sapiens_hsa030602.82639486
5Fatty acid degradation_Homo sapiens_hsa000712.72148333
6Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.71084908
7Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.63156023
8Tryptophan metabolism_Homo sapiens_hsa003802.52562590
9Pentose and glucuronate interconversions_Homo sapiens_hsa000402.27509515
10Complement and coagulation cascades_Homo sapiens_hsa046102.23861535
11Peroxisome_Homo sapiens_hsa041462.20590391
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.14515593
13Propanoate metabolism_Homo sapiens_hsa006402.10337427
14Nitrogen metabolism_Homo sapiens_hsa009102.02512635
15Fatty acid metabolism_Homo sapiens_hsa012121.94418990
16Leishmaniasis_Homo sapiens_hsa051401.93896131
17Osteoclast differentiation_Homo sapiens_hsa043801.93117852
18Butanoate metabolism_Homo sapiens_hsa006501.87283545
19Histidine metabolism_Homo sapiens_hsa003401.84789807
20Folate biosynthesis_Homo sapiens_hsa007901.83553800
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.82785793
22Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81827591
23Malaria_Homo sapiens_hsa051441.80576610
24Caffeine metabolism_Homo sapiens_hsa002321.77751035
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.77670566
26Selenocompound metabolism_Homo sapiens_hsa004501.72787505
27PPAR signaling pathway_Homo sapiens_hsa033201.66460629
28Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.64976811
29Allograft rejection_Homo sapiens_hsa053301.62719727
30Arginine biosynthesis_Homo sapiens_hsa002201.61570233
31Graft-versus-host disease_Homo sapiens_hsa053321.59685512
32Fatty acid elongation_Homo sapiens_hsa000621.57388742
33Type I diabetes mellitus_Homo sapiens_hsa049401.54030695
34Starch and sucrose metabolism_Homo sapiens_hsa005001.52395595
35Chemical carcinogenesis_Homo sapiens_hsa052041.49336826
36Tyrosine metabolism_Homo sapiens_hsa003501.48175037
37beta-Alanine metabolism_Homo sapiens_hsa004101.47476270
38Drug metabolism - other enzymes_Homo sapiens_hsa009831.47186184
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46460152
40Toll-like receptor signaling pathway_Homo sapiens_hsa046201.44652065
41Tuberculosis_Homo sapiens_hsa051521.44516020
42Rheumatoid arthritis_Homo sapiens_hsa053231.44298704
43ABC transporters_Homo sapiens_hsa020101.43136419
44Pertussis_Homo sapiens_hsa051331.41406858
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.41003467
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.40784035
47Other glycan degradation_Homo sapiens_hsa005111.36731837
48Glycosaminoglycan degradation_Homo sapiens_hsa005311.35615142
49Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.35558222
50Staphylococcus aureus infection_Homo sapiens_hsa051501.33795801
51Platelet activation_Homo sapiens_hsa046111.32454972
52Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.32123387
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31925354
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.29715884
55Asthma_Homo sapiens_hsa053101.28331492
56Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.26112425
57Phenylalanine metabolism_Homo sapiens_hsa003601.24240156
58Phagosome_Homo sapiens_hsa041451.23628264
59Intestinal immune network for IgA production_Homo sapiens_hsa046721.21078953
60Retinol metabolism_Homo sapiens_hsa008301.19388495
61Hematopoietic cell lineage_Homo sapiens_hsa046401.16775679
62Bile secretion_Homo sapiens_hsa049761.16255704
63Pyruvate metabolism_Homo sapiens_hsa006201.14684473
64Toxoplasmosis_Homo sapiens_hsa051451.07543748
65African trypanosomiasis_Homo sapiens_hsa051431.05742142
66Fat digestion and absorption_Homo sapiens_hsa049751.04991455
67Chemokine signaling pathway_Homo sapiens_hsa040621.03956393
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.02282808
69TNF signaling pathway_Homo sapiens_hsa046681.02122448
70B cell receptor signaling pathway_Homo sapiens_hsa046621.00065738
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.99075817
72Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.98616610
73Lysosome_Homo sapiens_hsa041420.98062451
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.97634782
75Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96859375
76Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.95729915
77Vitamin digestion and absorption_Homo sapiens_hsa049770.95435233
78NF-kappa B signaling pathway_Homo sapiens_hsa040640.94576284
79Mineral absorption_Homo sapiens_hsa049780.92962063
80N-Glycan biosynthesis_Homo sapiens_hsa005100.92164798
81Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.91553350
82Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.90164557
83Arginine and proline metabolism_Homo sapiens_hsa003300.89667957
84Galactose metabolism_Homo sapiens_hsa000520.87885274
85Dorso-ventral axis formation_Homo sapiens_hsa043200.87395777
86Jak-STAT signaling pathway_Homo sapiens_hsa046300.86940673
87Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.86342346
88Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.85810124
89Amoebiasis_Homo sapiens_hsa051460.84617730
90Leukocyte transendothelial migration_Homo sapiens_hsa046700.83720765
91Carbon metabolism_Homo sapiens_hsa012000.81766984
92Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.81032743
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.80514552
94Collecting duct acid secretion_Homo sapiens_hsa049660.78562619
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.74351439
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.72975136
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.72235229
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.72217450
99Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.72060265
100Thyroid hormone synthesis_Homo sapiens_hsa049180.71957845
101Influenza A_Homo sapiens_hsa051640.70566978
102Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.70220844
103Antigen processing and presentation_Homo sapiens_hsa046120.69135230
104Linoleic acid metabolism_Homo sapiens_hsa005910.68001984
105Sulfur relay system_Homo sapiens_hsa041220.66054602
106Measles_Homo sapiens_hsa051620.65752947
107Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.65572668
108Steroid biosynthesis_Homo sapiens_hsa001000.65344201
109Hepatitis C_Homo sapiens_hsa051600.63652261
110RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62778545
111Glutathione metabolism_Homo sapiens_hsa004800.61307349
112Renin secretion_Homo sapiens_hsa049240.58263324
113Lysine degradation_Homo sapiens_hsa003100.58199234
114T cell receptor signaling pathway_Homo sapiens_hsa046600.57868731
115Viral myocarditis_Homo sapiens_hsa054160.56952116
116Metabolic pathways_Homo sapiens_hsa011000.56441365
117Type II diabetes mellitus_Homo sapiens_hsa049300.56200195
118Sphingolipid signaling pathway_Homo sapiens_hsa040710.55562445
119Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54226347
120Arachidonic acid metabolism_Homo sapiens_hsa005900.53885438
121Cysteine and methionine metabolism_Homo sapiens_hsa002700.53796419
122Glycerolipid metabolism_Homo sapiens_hsa005610.53496474
123Salmonella infection_Homo sapiens_hsa051320.53412605
124Fructose and mannose metabolism_Homo sapiens_hsa000510.53178865
125Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.52737775
126Biosynthesis of amino acids_Homo sapiens_hsa012300.51704465
127Acute myeloid leukemia_Homo sapiens_hsa052210.51375691
128Phospholipase D signaling pathway_Homo sapiens_hsa040720.50810493
129Insulin resistance_Homo sapiens_hsa049310.50743505
130Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.48181484
131Ether lipid metabolism_Homo sapiens_hsa005650.47678365
132Prolactin signaling pathway_Homo sapiens_hsa049170.47180968
133Pentose phosphate pathway_Homo sapiens_hsa000300.46712926
134Protein digestion and absorption_Homo sapiens_hsa049740.46180517
135Prion diseases_Homo sapiens_hsa050200.45849371
136Insulin secretion_Homo sapiens_hsa049110.45833344
137Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.44575022
138Focal adhesion_Homo sapiens_hsa045100.43072123
139Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42245960
140Renin-angiotensin system_Homo sapiens_hsa046140.40293058
141Pancreatic secretion_Homo sapiens_hsa049720.39998115
142SNARE interactions in vesicular transport_Homo sapiens_hsa041300.38294031
143ECM-receptor interaction_Homo sapiens_hsa045120.37899581
144Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.35759905
145Glucagon signaling pathway_Homo sapiens_hsa049220.34444699
146Adipocytokine signaling pathway_Homo sapiens_hsa049200.33014856
147Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.31012333
148Regulation of autophagy_Homo sapiens_hsa041400.30878050
149Circadian rhythm_Homo sapiens_hsa047100.29992361
150Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27067545
151Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.23248400
152Cyanoamino acid metabolism_Homo sapiens_hsa004600.19216123
153Autoimmune thyroid disease_Homo sapiens_hsa053200.19159722
154Sphingolipid metabolism_Homo sapiens_hsa006000.16658105
155Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.15963760
156Ovarian steroidogenesis_Homo sapiens_hsa049130.14153813
157Fatty acid biosynthesis_Homo sapiens_hsa000610.14016303
158Legionellosis_Homo sapiens_hsa051340.11650584
159Glycerophospholipid metabolism_Homo sapiens_hsa005640.11061484
160Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.10331947

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