CPS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The mitochondrial enzyme encoded by this gene catalyzes synthesis of carbamoyl phosphate from ammonia and bicarbonate. This reaction is the first committed step of the urea cycle, which is important in the removal of excess urea from cells. The encoded protein may also represent a core mitochondrial nucleoid protein. Three transcript variants encoding different isoforms have been found for this gene. The shortest isoform may not be localized to the mitochondrion. Mutations in this gene have been associated with carbamoyl phosphate synthetase deficiency, susceptibility to persistent pulmonary hypertension, and susceptibility to venoocclusive disease after bone marrow transplantation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of protein activation cascade (GO:2000258)7.82207352
2L-phenylalanine catabolic process (GO:0006559)7.64459683
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)7.64459683
4negative regulation of complement activation (GO:0045916)7.55556840
5L-phenylalanine metabolic process (GO:0006558)7.29375970
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)7.29375970
7aromatic amino acid family catabolic process (GO:0009074)6.84269658
8triglyceride-rich lipoprotein particle remodeling (GO:0034370)6.27330480
9indole-containing compound catabolic process (GO:0042436)6.12684216
10indolalkylamine catabolic process (GO:0046218)6.12684216
11tryptophan catabolic process (GO:0006569)6.12684216
12epoxygenase P450 pathway (GO:0019373)6.04674518
13exogenous drug catabolic process (GO:0042738)6.01886497
14kynurenine metabolic process (GO:0070189)5.99748723
15bile acid biosynthetic process (GO:0006699)5.96437988
16nuclear pore complex assembly (GO:0051292)5.93190135
17negative regulation of humoral immune response (GO:0002921)5.81019911
18tryptophan metabolic process (GO:0006568)5.77506868
19omega-hydroxylase P450 pathway (GO:0097267)5.71090024
20glyoxylate metabolic process (GO:0046487)5.69803677
21* urea metabolic process (GO:0019627)5.62107926
22* urea cycle (GO:0000050)5.62107926
23negative regulation of fibrinolysis (GO:0051918)5.61450566
24alpha-linolenic acid metabolic process (GO:0036109)5.54108419
25cysteine metabolic process (GO:0006534)5.49305575
26high-density lipoprotein particle remodeling (GO:0034375)5.48477271
27complement activation, alternative pathway (GO:0006957)5.42968082
28regulation of protein activation cascade (GO:2000257)5.42510825
29regulation of fibrinolysis (GO:0051917)5.40204957
30sulfur amino acid catabolic process (GO:0000098)5.39051302
31protein carboxylation (GO:0018214)5.32844434
32peptidyl-glutamic acid carboxylation (GO:0017187)5.32844434
33serine family amino acid catabolic process (GO:0009071)5.18261717
34bile acid metabolic process (GO:0008206)5.14480236
35* nitrogen cycle metabolic process (GO:0071941)5.11439561
36regulation of complement activation (GO:0030449)5.05648798
37nuclear pore organization (GO:0006999)4.98001051
38aromatic amino acid family metabolic process (GO:0009072)4.97011183
39tyrosine metabolic process (GO:0006570)4.87533506
40fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.85221753
41regulation of triglyceride catabolic process (GO:0010896)4.82876578
42regulation of cholesterol esterification (GO:0010872)4.82875499
43reverse cholesterol transport (GO:0043691)4.82779311
44macromolecular complex remodeling (GO:0034367)4.82042942
45plasma lipoprotein particle remodeling (GO:0034369)4.82042942
46protein-lipid complex remodeling (GO:0034368)4.82042942
47amino-acid betaine metabolic process (GO:0006577)4.67701194
48lysine catabolic process (GO:0006554)4.64138320
49lysine metabolic process (GO:0006553)4.64138320
50* alpha-amino acid catabolic process (GO:1901606)4.63586300
51triglyceride homeostasis (GO:0070328)4.62740299
52acylglycerol homeostasis (GO:0055090)4.62740299
53bile acid and bile salt transport (GO:0015721)4.55421829
54phospholipid efflux (GO:0033700)4.54011757
55negative regulation of cholesterol transport (GO:0032375)4.52841510
56negative regulation of sterol transport (GO:0032372)4.52841510
57glycine metabolic process (GO:0006544)4.47371633
58imidazole-containing compound metabolic process (GO:0052803)4.43639330
59drug metabolic process (GO:0017144)4.42918363
60plasma lipoprotein particle clearance (GO:0034381)4.42078639
61* midgut development (GO:0007494)4.40965385
62* homocysteine metabolic process (GO:0050667)4.39354108
63cellular glucuronidation (GO:0052695)4.37387331
64cellular ketone body metabolic process (GO:0046950)4.35805858
65indolalkylamine metabolic process (GO:0006586)4.34848014
66glutamate metabolic process (GO:0006536)4.33136761
67cholesterol efflux (GO:0033344)4.31287056
68coenzyme catabolic process (GO:0009109)4.30907452
69pore complex assembly (GO:0046931)4.29657261
70* cellular amino acid catabolic process (GO:0009063)4.26178014
71amine catabolic process (GO:0009310)4.23812300
72cellular biogenic amine catabolic process (GO:0042402)4.23812300
73serine family amino acid metabolic process (GO:0009069)4.23490790
74low-density lipoprotein particle remodeling (GO:0034374)4.22106698
75cAMP catabolic process (GO:0006198)4.16393232
76plasma lipoprotein particle assembly (GO:0034377)4.14227501
77arginine metabolic process (GO:0006525)4.12055661
78cellular modified amino acid catabolic process (GO:0042219)4.10940097
79serine family amino acid biosynthetic process (GO:0009070)4.10514786
80benzene-containing compound metabolic process (GO:0042537)4.10245832
81dicarboxylic acid biosynthetic process (GO:0043650)4.08796959
82ethanol oxidation (GO:0006069)4.06632631
83drug catabolic process (GO:0042737)4.04588306
84fibrinolysis (GO:0042730)4.00208502
85regulation of humoral immune response (GO:0002920)3.99627358
86oxidative demethylation (GO:0070989)3.98780489
87aldehyde catabolic process (GO:0046185)3.98592283
88very-low-density lipoprotein particle assembly (GO:0034379)3.98443328
89regulation of bile acid biosynthetic process (GO:0070857)3.97185274
90phospholipid homeostasis (GO:0055091)3.92295317
91S-adenosylmethionine metabolic process (GO:0046500)3.89203258
92glucuronate metabolic process (GO:0019585)3.87599698
93uronic acid metabolic process (GO:0006063)3.87599698
94heme transport (GO:0015886)3.87310162
95blood coagulation, intrinsic pathway (GO:0007597)3.86623642
96cholesterol homeostasis (GO:0042632)3.85754382
97hormone catabolic process (GO:0042447)3.82214386
98sterol homeostasis (GO:0055092)3.79397999
99positive regulation of vascular permeability (GO:0043117)3.78289579
100ketone body metabolic process (GO:1902224)3.76993782
101positive regulation of lipid catabolic process (GO:0050996)3.75253542
102cofactor catabolic process (GO:0051187)3.74990582
103folic acid metabolic process (GO:0046655)3.74646171
104complement activation, classical pathway (GO:0006958)3.74346736
105regulation of centriole replication (GO:0046599)3.74229073
106regulation of cholesterol homeostasis (GO:2000188)3.73704098
107protein activation cascade (GO:0072376)3.73491350
108complement activation (GO:0006956)3.73427723
109positive regulation of triglyceride lipase activity (GO:0061365)3.73228559
110positive regulation of lipoprotein lipase activity (GO:0051006)3.73228559
111protein-lipid complex assembly (GO:0065005)3.72343933
112* organic acid catabolic process (GO:0016054)3.71635194
113* carboxylic acid catabolic process (GO:0046395)3.71635194
114plasma lipoprotein particle organization (GO:0071827)3.69094340
115acetyl-CoA metabolic process (GO:0006084)3.68748517
116negative regulation of lipase activity (GO:0060192)3.67792704
117short-chain fatty acid metabolic process (GO:0046459)3.61553782
118flavonoid metabolic process (GO:0009812)3.59940713
119cytolysis (GO:0019835)3.59550817
120cyclic nucleotide catabolic process (GO:0009214)3.57359616
121lipoprotein metabolic process (GO:0042157)3.57253899
122negative regulation of B cell mediated immunity (GO:0002713)3.38921423
123negative regulation of immunoglobulin mediated immune response (GO:0002890)3.38921423
124L-alpha-amino acid transmembrane transport (GO:1902475)3.35132050
125cGMP-mediated signaling (GO:0019934)3.34685444
126establishment of apical/basal cell polarity (GO:0035089)3.31402249
127acute-phase response (GO:0006953)3.27036199
128drug transmembrane transport (GO:0006855)3.16670588
129iron ion import (GO:0097286)3.14267768
130glutamine family amino acid biosynthetic process (GO:0009084)3.14018131
131ethanol metabolic process (GO:0006067)3.10738518
132L-serine metabolic process (GO:0006563)3.10454760
133polyketide metabolic process (GO:0030638)3.08813828
134doxorubicin metabolic process (GO:0044598)3.08813828
135daunorubicin metabolic process (GO:0044597)3.08813828
136regulation of plasminogen activation (GO:0010755)3.00715028
137phenylpropanoid metabolic process (GO:0009698)2.99807831
138intestinal cholesterol absorption (GO:0030299)2.99504842
139positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.97850380
140regulation of lipoprotein particle clearance (GO:0010984)2.96173415
141response to nitrosative stress (GO:0051409)2.89586186
142biotin metabolic process (GO:0006768)2.88083259
143oxaloacetate metabolic process (GO:0006107)2.86594236
144alkaloid metabolic process (GO:0009820)2.84271368
145regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.84044575
146negative regulation of hemostasis (GO:1900047)2.80546892
147negative regulation of blood coagulation (GO:0030195)2.80546892

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.88759170
2* RXR_22158963_ChIP-Seq_LIVER_Mouse8.36608220
3PPARA_22158963_ChIP-Seq_LIVER_Mouse7.19900330
4* EGR1_23403033_ChIP-Seq_LIVER_Mouse6.96483907
5* LXR_22158963_ChIP-Seq_LIVER_Mouse6.54877868
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse5.30878488
7* CEBPA_23403033_ChIP-Seq_LIVER_Mouse5.05731597
8PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.68139524
9* NR1I2_20693526_ChIP-Seq_LIVER_Mouse4.06249379
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse4.02085449
11FOXM1_23109430_ChIP-Seq_U2OS_Human3.12801230
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.88932674
13AR_21909140_ChIP-Seq_LNCAP_Human2.59315249
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.58412566
15* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat2.07432050
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human2.06300689
17ESR1_17901129_ChIP-ChIP_LIVER_Mouse11.9633028
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.98132690
19KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.92390886
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88782484
21PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.86796196
22FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.71907438
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.66344128
24* FOXA2_19822575_ChIP-Seq_HepG2_Human1.65822263
25MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64304971
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.62577501
27E2F1_21310950_ChIP-Seq_MCF-7_Human1.58706541
28CLOCK_20551151_ChIP-Seq_293T_Human1.57759217
29GATA1_22025678_ChIP-Seq_K562_Human1.55384270
30HTT_18923047_ChIP-ChIP_STHdh_Human1.55372828
31SALL1_21062744_ChIP-ChIP_HESCs_Human1.52511961
32SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.46157633
33* HNF4A_19822575_ChIP-Seq_HepG2_Human1.45386899
34EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.40947092
35XRN2_22483619_ChIP-Seq_HELA_Human1.37039760
36MYC_18358816_ChIP-ChIP_MESCs_Mouse1.34855661
37CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.34605228
38DCP1A_22483619_ChIP-Seq_HELA_Human1.32453037
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.28343405
40HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.26245826
41STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.22582503
42THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22111591
43NELFA_20434984_ChIP-Seq_ESCs_Mouse1.20157658
44RXRA_24833708_ChIP-Seq_LIVER_Mouse1.16764076
45ZFX_18555785_ChIP-Seq_MESCs_Mouse1.15425537
46RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.14919380
47TFEB_21752829_ChIP-Seq_HELA_Human1.14793545
48NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.14757122
49ESR1_15608294_ChIP-ChIP_MCF-7_Human1.14001292
50KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.13615476
51MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.11748644
52HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.11579127
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11065516
54EGR1_19374776_ChIP-ChIP_THP-1_Human1.10554396
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.07542058
56SOX2_27498859_Chip-Seq_STOMACH_Mouse1.06167967
57ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.05697464
58EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.05427980
59KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.03152066
60IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02786622
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.01957688
62KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.01721716
63MYCN_18555785_ChIP-Seq_MESCs_Mouse1.01462123
64SOX17_20123909_ChIP-Seq_XEN_Mouse1.01317427
65TTF2_22483619_ChIP-Seq_HELA_Human1.00307730
66CREB1_15753290_ChIP-ChIP_HEK293T_Human0.98206415
67ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.97512717
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96777665
69SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.96093358
70SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.96093358
71CHD1_26751641_Chip-Seq_LNCaP_Human0.95623860
72SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.95325235
73KDM5A_27292631_Chip-Seq_BREAST_Human0.94333429
74GATA4_25053715_ChIP-Seq_YYC3_Human0.92736807
75PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.91352102
76DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90943204
77SMC4_20622854_ChIP-Seq_HELA_Human0.90185471
78* PADI4_21655091_ChIP-ChIP_MCF-7_Human0.89853830
79KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87281684
80ELK1_19687146_ChIP-ChIP_HELA_Human0.87121756
81GATA6_21074721_ChIP-Seq_CACO-2_Human0.86363698
82P300_27058665_Chip-Seq_ZR-75-30cells_Human0.85484499
83E2F1_18555785_ChIP-Seq_MESCs_Mouse0.84997250
84GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.84899369
85IRF8_22096565_ChIP-ChIP_GC-B_Human0.83575259
86CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83444409
87CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.83118917
88AUTS2_25519132_ChIP-Seq_293T-REX_Human0.82190973
89HNFA_21074721_ChIP-Seq_CACO-2_Human0.81586649
90ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.81454889
91BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.81426497
92ZNF263_19887448_ChIP-Seq_K562_Human0.79929335
93PHF8_20622853_ChIP-Seq_HELA_Human0.79445082
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.78747711
95UBF1/2_26484160_Chip-Seq_HMECs_Human0.78155432
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.77805887
97Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.77012872
98KAP1_22055183_ChIP-Seq_ESCs_Mouse0.76871710
99ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76376093
100* TCF4_18268006_ChIP-ChIP_LS174T_Human0.76193313
101NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.75967039
102CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.75818750
103SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.75814738
104RARG_19884340_ChIP-ChIP_MEFs_Mouse0.74510836
105E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.74382268
106AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.74218924
107SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.73251191
108SALL4_18804426_ChIP-ChIP_XEN_Mouse0.72861041
109RARA_24833708_ChIP-Seq_LIVER_Mouse0.72608606
110CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.71211803
111ESR2_21235772_ChIP-Seq_MCF-7_Human0.66717853
112RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.66527030
113NRF2_20460467_ChIP-Seq_MEFs_Mouse0.66148556
114NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.66148556
115CDX2_20551321_ChIP-Seq_CACO-2_Human0.66053312
116NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.60626460
117RARB_24833708_ChIP-Seq_LIVER_Mouse0.60336362
118CEBPB_22108803_ChIP-Seq_LS180_Human0.58147757
119BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.57942098
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.57823452
121RAD21_21589869_ChIP-Seq_MESCs_Mouse0.56991155
122NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.55582317
123FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.55509259
124FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.54736180
125EGR1_19032775_ChIP-ChIP_M12_Human0.54029231
126TAF15_26573619_Chip-Seq_HEK293_Human0.53032398
127AR_20517297_ChIP-Seq_VCAP_Human0.52128672
128GATA6_25053715_ChIP-Seq_YYC3_Human0.50929025
129CBP_21632823_ChIP-Seq_H3396_Human0.50835471
130FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.50193625
131MYC_19915707_ChIP-ChIP_AK7_Human0.50115982
132FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.49633576
133STAT3_1855785_ChIP-Seq_MESCs_Mouse0.48891262
134PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.48636022
135PPAR_26484153_Chip-Seq_NCI-H1993_Human0.48634515
136* STAT1_17558387_ChIP-Seq_HELA_Human0.48601688
137ESET_19884257_ChIP-Seq_ESCs_Mouse0.48016343
138NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.47300710
139LXR_22292898_ChIP-Seq_THP-1_Human0.47147675
140FOXO3_23340844_ChIP-Seq_DLD1_Human0.47118373
141P53_21459846_ChIP-Seq_SAOS-2_Human0.46355905
142* PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.46117243
143PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.45574935
144ESR1_21235772_ChIP-Seq_MCF-7_Human0.45050622
145ESR1_20079471_ChIP-ChIP_T-47D_Human0.44827992
146GATA2_19941826_ChIP-Seq_K562_Human0.43384260
147E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.43308059
148PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.43090110
149BCAT_22108803_ChIP-Seq_LS180_Human0.42768265
150GATA1_19941826_ChIP-Seq_K562_Human0.42738138
151* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.41884504
152SOX2_20726797_ChIP-Seq_SW620_Human0.40870881
153TAF2_19829295_ChIP-Seq_ESCs_Human0.40363033
154GATA1_19941827_ChIP-Seq_MEL_Mouse0.39266242
155BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.38469543
156CDX2_22108803_ChIP-Seq_LS180_Human0.37752601
157* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.36282397
158FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.35753927
159SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.35557006
160GATA3_24758297_ChIP-Seq_MCF-7_Human0.35504422
161EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.35276781
162MYC_27129775_Chip-Seq_CORNEA_Mouse0.35258000
163LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.34752872
164ERG_21242973_ChIP-ChIP_JURKAT_Human0.34468458
165NCOR_22424771_ChIP-Seq_293T_Human0.34157495

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system8.15541021
2MP0005360_urolithiasis7.75723465
3MP0005085_abnormal_gallbladder_physiolo6.52379935
4MP0005365_abnormal_bile_salt6.16461453
5MP0008875_abnormal_xenobiotic_pharmacok5.13119547
6MP0003806_abnormal_nucleotide_metabolis4.22539809
7MP0003252_abnormal_bile_duct3.99909971
8MP0010329_abnormal_lipoprotein_level3.60360731
9MP0009840_abnormal_foam_cell3.20665759
10MP0005083_abnormal_biliary_tract3.08736213
11MP0005332_abnormal_amino_acid2.76256834
12MP0003195_calcinosis2.76210353
13MP0001666_abnormal_nutrient_absorption2.70973092
14MP0002009_preneoplasia2.55880995
15MP0008057_abnormal_DNA_replication2.54243604
16MP0003191_abnormal_cellular_cholesterol2.22644561
17MP0004019_abnormal_vitamin_homeostasis2.19396817
18MP0000609_abnormal_liver_physiology2.17118461
19MP0002118_abnormal_lipid_homeostasis2.07403421
20MP0010352_gastrointestinal_tract_polyps2.04944223
21MP0000013_abnormal_adipose_tissue2.02262504
22MP0010094_abnormal_chromosome_stability2.00760260
23MP0002138_abnormal_hepatobiliary_system2.00749104
24MP0003868_abnormal_feces_composition1.94873168
25MP0000003_abnormal_adipose_tissue1.82092243
26MP0005319_abnormal_enzyme/_coenzyme1.81443886
27MP0004957_abnormal_blastocyst_morpholog1.79092925
28MP0008058_abnormal_DNA_repair1.72979034
29MP0004233_abnormal_muscle_weight1.68229919
30MP0001764_abnormal_homeostasis1.67567122
31MP0009697_abnormal_copulation1.66093483
32MP0003693_abnormal_embryo_hatching1.59182650
33MP0005584_abnormal_enzyme/coenzyme_acti1.54503229
34MP0003077_abnormal_cell_cycle1.54174345
35MP0002877_abnormal_melanocyte_morpholog1.50174751
36MP0005451_abnormal_body_composition1.36676901
37MP0005076_abnormal_cell_differentiation1.36531035
38MP0003011_delayed_dark_adaptation1.34388738
39MP0003111_abnormal_nucleus_morphology1.30292350
40MP0002697_abnormal_eye_size1.29588844
41MP0003186_abnormal_redox_activity1.23371145
42MP0009643_abnormal_urine_homeostasis1.22661179
43MP0003656_abnormal_erythrocyte_physiolo1.21950231
44MP0000598_abnormal_liver_morphology1.18707741
45MP0003705_abnormal_hypodermis_morpholog1.17814705
46MP0001348_abnormal_lacrimal_gland1.14481643
47MP0002254_reproductive_system_inflammat1.11633596
48MP0005623_abnormal_meninges_morphology1.11428962
49MP0005647_abnormal_sex_gland1.07406822
50MP0000604_amyloidosis1.05211495
51MP0009764_decreased_sensitivity_to1.02347061
52MP0009763_increased_sensitivity_to1.01949783
53MP0005636_abnormal_mineral_homeostasis0.91615948
54MP0001915_intracranial_hemorrhage0.91224843
55MP0010307_abnormal_tumor_latency0.91170738
56MP0010368_abnormal_lymphatic_system0.89495586
57MP0004808_abnormal_hematopoietic_stem0.89142787
58MP0005408_hypopigmentation0.87641401
59MP0008469_abnormal_protein_level0.87211252
60MP0003984_embryonic_growth_retardation0.86524302
61MP0002088_abnormal_embryonic_growth/wei0.85447824
62MP0003879_abnormal_hair_cell0.85344133
63* MP0009642_abnormal_blood_homeostasis0.85100027
64MP0008932_abnormal_embryonic_tissue0.83410280
65MP0000490_abnormal_crypts_of0.81839275
66MP0005084_abnormal_gallbladder_morpholo0.81163728
67MP0006138_congestive_heart_failure0.81040730
68MP0009765_abnormal_xenobiotic_induced0.79881868
69MP0005376_homeostasis/metabolism_phenot0.79621508
70MP0002086_abnormal_extraembryonic_tissu0.79021567
71MP0005375_adipose_tissue_phenotype0.78401685
72MP0005220_abnormal_exocrine_pancreas0.78354104
73MP0005670_abnormal_white_adipose0.77886634
74MP0001672_abnormal_embryogenesis/_devel0.77700756
75MP0005380_embryogenesis_phenotype0.77700756
76MP0006036_abnormal_mitochondrial_physio0.77595183
77MP0002078_abnormal_glucose_homeostasis0.76648388
78MP0002396_abnormal_hematopoietic_system0.74234939
79MP0001661_extended_life_span0.71339073
80MP0002971_abnormal_brown_adipose0.71239984
81MP0002166_altered_tumor_susceptibility0.69993115
82MP0002876_abnormal_thyroid_physiology0.69858799
83MP0009053_abnormal_anal_canal0.69009675
84MP0004130_abnormal_muscle_cell0.67976668
85MP0003699_abnormal_female_reproductive0.67823328
86MP0004147_increased_porphyrin_level0.67704529
87MP0005334_abnormal_fat_pad0.67308937
88MP0005409_darkened_coat_color0.67145384
89MP0002092_abnormal_eye_morphology0.66761343
90MP0001730_embryonic_growth_arrest0.66035001
91MP0005266_abnormal_metabolism0.64992973
92MP0003566_abnormal_cell_adhesion0.64395224
93MP0003690_abnormal_glial_cell0.64194026
94MP0005535_abnormal_body_temperature0.63198704
95MP0005197_abnormal_uvea_morphology0.62562645
96MP0010030_abnormal_orbit_morphology0.61515579
97MP0000350_abnormal_cell_proliferation0.60591745
98MP0001697_abnormal_embryo_size0.59455313
99MP0003329_amyloid_beta_deposits0.59205909
100MP0003183_abnormal_peptide_metabolism0.58762720
101MP0005448_abnormal_energy_balance0.58751645
102MP0002080_prenatal_lethality0.57902099
103MP0003959_abnormal_lean_body0.57898240
104MP0000639_abnormal_adrenal_gland0.57845813
105MP0001756_abnormal_urination0.57120226
106MP0010678_abnormal_skin_adnexa0.55735401
107MP0006035_abnormal_mitochondrial_morpho0.55203606
108MP0005464_abnormal_platelet_physiology0.53136188
109MP0003950_abnormal_plasma_membrane0.52651584
110MP0005187_abnormal_penis_morphology0.52465097
111MP0002084_abnormal_developmental_patter0.51695473
112MP0003786_premature_aging0.51669955
113MP0002822_catalepsy0.50974330
114MP0003937_abnormal_limbs/digits/tail_de0.49989117
115MP0000537_abnormal_urethra_morphology0.48841483
116MP0003718_maternal_effect0.48200008
117MP0002928_abnormal_bile_duct0.48189251
118MP0005395_other_phenotype0.47235561
119MP0008873_increased_physiological_sensi0.45581392
120MP0002136_abnormal_kidney_physiology0.44411360
121MP0003638_abnormal_response/metabolism_0.43959700
122MP0008874_decreased_physiological_sensi0.42296021
123MP0005248_abnormal_Harderian_gland0.41515709
124MP0003724_increased_susceptibility_to0.40995447
125MP0003436_decreased_susceptibility_to0.40619014
126MP0004782_abnormal_surfactant_physiolog0.40596084
127MP0008872_abnormal_physiological_respon0.40484833
128MP0009384_cardiac_valve_regurgitation0.40353879
129MP0003953_abnormal_hormone_level0.40092581
130MP0000579_abnormal_nail_morphology0.38920736
131MP0005166_decreased_susceptibility_to0.36849118
132MP0005666_abnormal_adipose_tissue0.36720265
133MP0003075_altered_response_to0.36576013
134MP0009672_abnormal_birth_weight0.35851289
135MP0010234_abnormal_vibrissa_follicle0.35033813
136MP0004381_abnormal_hair_follicle0.34430128
137MP0002837_dystrophic_cardiac_calcinosis0.33418766
138MP0002796_impaired_skin_barrier0.33404455
139MP0004264_abnormal_extraembryonic_tissu0.32691041
140MP0009115_abnormal_fat_cell0.31582440
141MP0001243_abnormal_dermal_layer0.31437548
142MP0000230_abnormal_systemic_arterial0.30831310
143MP0000249_abnormal_blood_vessel0.30646517
144MP0004883_abnormal_blood_vessel0.29811184
145MP0001853_heart_inflammation0.29768206
146MP0001881_abnormal_mammary_gland0.29437890
147MP0002970_abnormal_white_adipose0.28421244
148MP0001845_abnormal_inflammatory_respons0.28080652
149MP0002168_other_aberrant_phenotype0.27592434
150MP0003300_gastrointestinal_ulcer0.27397620
151MP0002132_abnormal_respiratory_system0.26725036
152MP0002060_abnormal_skin_morphology0.26685675

Predicted human phenotypes

RankGene SetZ-score
1Intrahepatic cholestasis (HP:0001406)7.46293031
2Deep venous thrombosis (HP:0002625)7.42180220
3Abnormality of aromatic amino acid family metabolism (HP:0004338)7.36292761
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.89460472
5Hypobetalipoproteinemia (HP:0003563)6.75544540
6Prolonged partial thromboplastin time (HP:0003645)6.59195244
7Xanthomatosis (HP:0000991)6.39523930
8Hyperlipoproteinemia (HP:0010980)5.40406886
9Complement deficiency (HP:0004431)5.38812723
10Hypolipoproteinemia (HP:0010981)4.94006225
11Epidermoid cyst (HP:0200040)4.81796060
12Joint hemorrhage (HP:0005261)4.76611346
13Abnormality of the common coagulation pathway (HP:0010990)4.53540678
14Abnormality of the level of lipoprotein cholesterol (HP:0010979)4.51327194
15* Hyperammonemia (HP:0001987)4.43325786
16Hyperglycinemia (HP:0002154)4.36092612
17Abnormality of methionine metabolism (HP:0010901)4.35845576
18Abnormality of sulfur amino acid metabolism (HP:0004339)4.32213426
19Fat malabsorption (HP:0002630)4.30841057
20Abnormality of aspartate family amino acid metabolism (HP:0010899)4.22418048
21Ketosis (HP:0001946)4.18549830
22Cerebellar dysplasia (HP:0007033)4.14945490
23Hypoalphalipoproteinemia (HP:0003233)4.13060316
24Conjugated hyperbilirubinemia (HP:0002908)4.07793834
25Fair hair (HP:0002286)4.05211561
26Abnormality of pyrimidine metabolism (HP:0004353)3.95811717
27Abnormality of complement system (HP:0005339)3.93336942
28Hyperglycinuria (HP:0003108)3.89623984
29Abnormality of serine family amino acid metabolism (HP:0010894)3.88169881
30Abnormality of glycine metabolism (HP:0010895)3.88169881
31Hypercholesterolemia (HP:0003124)3.82496233
32* Abnormality of glutamine family amino acid metabolism (HP:0010902)3.80601151
33Hypoglycemic coma (HP:0001325)3.80594552
34Abnormality of the intrinsic pathway (HP:0010989)3.75016922
35Retinal atrophy (HP:0001105)3.54212316
36Hyperbilirubinemia (HP:0002904)3.40784214
37Submucous cleft hard palate (HP:0000176)3.27671619
38Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.27616071
39Abnormality of fatty-acid metabolism (HP:0004359)3.19932662
40Abnormality of nucleobase metabolism (HP:0010932)3.09299944
41Acanthocytosis (HP:0001927)3.09266822
42Abnormality of serum amino acid levels (HP:0003112)3.09233056
43Spontaneous abortion (HP:0005268)3.05208359
44Steatorrhea (HP:0002570)3.04229260
45Hepatocellular carcinoma (HP:0001402)3.03123154
46Delayed CNS myelination (HP:0002188)3.02795002
47Skin nodule (HP:0200036)2.98804710
48Ketoacidosis (HP:0001993)2.97165972
49Myocardial infarction (HP:0001658)2.94658779
50Hypochromic microcytic anemia (HP:0004840)2.92407657
51Abnormality of alanine metabolism (HP:0010916)2.90396435
52Hyperalaninemia (HP:0003348)2.90396435
53Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.90396435
54Metabolic acidosis (HP:0001942)2.73440941
55Blue irides (HP:0000635)2.67440871
56Systemic lupus erythematosus (HP:0002725)2.66824441
57Abnormality of purine metabolism (HP:0004352)2.66044057
58Generalized hypopigmentation of hair (HP:0011358)2.62198236
59Abnormality of glycolysis (HP:0004366)2.61667476
60Abnormality of the Achilles tendon (HP:0005109)2.60624556
61Vascular calcification (HP:0004934)2.56294230
62Glomerulonephritis (HP:0000099)2.55397817
63Increased serum pyruvate (HP:0003542)2.54968521
64Calcaneovalgus deformity (HP:0001848)2.51197722
65* Lethargy (HP:0001254)2.49475332
66Elbow flexion contracture (HP:0002987)2.48837344
67Spastic diplegia (HP:0001264)2.48832362
68Hypoglycemic seizures (HP:0002173)2.48504968
69Abnormality of the nasal septum (HP:0000419)2.48127982
70Abnormality of dicarboxylic acid metabolism (HP:0010995)2.46674023
71Dicarboxylic aciduria (HP:0003215)2.46674023
72Abnormal gallbladder morphology (HP:0012437)2.45726332
73Cholelithiasis (HP:0001081)2.38183782
74Mitral stenosis (HP:0001718)2.36112456
75Gout (HP:0001997)2.34752923
76Cholecystitis (HP:0001082)2.33928261
77Abnormal gallbladder physiology (HP:0012438)2.33928261
78Malnutrition (HP:0004395)2.33621053
79Neonatal onset (HP:0003623)2.30828006
80Esophageal varix (HP:0002040)2.28645167
81Sparse lateral eyebrow (HP:0005338)2.27609206
82Recurrent gram-negative bacterial infections (HP:0005420)2.27403026
83Cardiovascular calcification (HP:0011915)2.27207059
84Gingival bleeding (HP:0000225)2.26173009
85* Alkalosis (HP:0001948)2.25500137
86Microvesicular hepatic steatosis (HP:0001414)2.24436781
87Amyloidosis (HP:0011034)2.24221733
88Poikilocytosis (HP:0004447)2.22382466
89Ragged-red muscle fibers (HP:0003200)2.18099917
90* Irritability (HP:0000737)2.16419844
91Menorrhagia (HP:0000132)2.16036376
92Impaired pain sensation (HP:0007328)2.15611432
93Abnormality of pain sensation (HP:0010832)2.15611432
94Reduced antithrombin III activity (HP:0001976)2.15493080
95Osteomalacia (HP:0002749)2.14304192
96* Cerebral edema (HP:0002181)2.13545456
97Pancreatitis (HP:0001733)2.13064187
98Late onset (HP:0003584)2.11197646
99Deformed tarsal bones (HP:0008119)2.10575104
100Sensorimotor neuropathy (HP:0007141)2.08672632
101Thrombophlebitis (HP:0004418)2.07355802
102Enlarged kidneys (HP:0000105)2.06267905
103Abnormality of the periventricular white matter (HP:0002518)2.03819736
104Brushfield spots (HP:0001088)2.03595174
105Vertebral compression fractures (HP:0002953)2.00951121
106Hyperinsulinemic hypoglycemia (HP:0000825)2.00537693
107Megaloblastic anemia (HP:0001889)2.00392042
108Abnormality of the calcaneus (HP:0008364)2.00113671
109Achilles tendon contracture (HP:0001771)1.98327812
110Abnormality of the gallbladder (HP:0005264)1.98296660
111Hemorrhage of the eye (HP:0011885)1.95041084
112Overlapping toe (HP:0001845)1.94755664
113Opisthotonus (HP:0002179)1.94567301
114Generalized aminoaciduria (HP:0002909)1.94507634
115Dysmetric saccades (HP:0000641)1.94188541
116Asymmetry of the thorax (HP:0001555)1.93836367
117Chromosomal breakage induced by crosslinking agents (HP:0003221)1.93210392
118* Vomiting (HP:0002013)1.92813060
119Arthropathy (HP:0003040)1.90479349
120Hydroxyprolinuria (HP:0003080)1.90258739
121Abnormality of proline metabolism (HP:0010907)1.90258739
122Rickets (HP:0002748)1.89911557
123Abnormality of iron homeostasis (HP:0011031)1.88430971
124Abnormality of transition element cation homeostasis (HP:0011030)1.88326604
125Abnormal cartilage morphology (HP:0002763)1.87840555
126Chromsome breakage (HP:0040012)1.87117499
127Abnormality of the ischium (HP:0003174)1.84292003
128Abnormal enzyme/coenzyme activity (HP:0012379)1.83505977
129Renal cortical cysts (HP:0000803)1.82538226
130Elevated hepatic transaminases (HP:0002910)1.81424754
131Nephritis (HP:0000123)1.80955893
132Abnormality of vitamin metabolism (HP:0100508)1.80852753
133Knee flexion contracture (HP:0006380)1.80311238
134Pathologic fracture (HP:0002756)1.79742995
135Hypophosphatemic rickets (HP:0004912)1.79692023
136Osteolytic defects of the hand bones (HP:0009699)1.79013824
137Osteolytic defects of the phalanges of the hand (HP:0009771)1.79013824
138Hyperglycemia (HP:0003074)1.77286788
139Progressive muscle weakness (HP:0003323)1.75964772
140Oligodactyly (hands) (HP:0001180)1.73444094
141Status epilepticus (HP:0002133)1.72778787
142Acute hepatic failure (HP:0006554)1.72481455
143Scanning speech (HP:0002168)1.70360985
144Increased circulating renin level (HP:0000848)1.68522120
145Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)1.68158976
146Back pain (HP:0003418)1.62005001
147Deep philtrum (HP:0002002)1.61795022
148Amblyopia (HP:0000646)1.61258510
149Mild short stature (HP:0003502)1.60984529
150Elevated alkaline phosphatase (HP:0003155)1.59720796
151Abnormal delivery (HP:0001787)1.57341368
152Ulnar bowing (HP:0003031)1.54528858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK29.62729100
2BCKDK6.74850207
3SIK14.56373133
4FGFR44.44719386
5ERN13.96135930
6INSRR3.22084739
7TAOK33.20172220
8ERBB43.13442329
9STK392.83588481
10WNK42.72367078
11MST1R2.51680821
12NEK62.32469065
13PKN22.31230330
14EEF2K2.30649982
15FRK2.24897939
16BRSK22.24852431
17MAP2K42.24469777
18MAPK112.02474878
19LATS11.97410510
20ACVR1B1.97064716
21NEK11.94810142
22OXSR11.94570883
23FLT31.87662846
24CDK121.85499719
25PIK3CG1.83206568
26MKNK11.73595570
27TSSK61.66166457
28TYK21.65635923
29TTK1.65599007
30CDC71.65262766
31PTK61.58093720
32TRIB31.58072700
33FGFR21.53805978
34RPS6KB21.51479117
35DAPK21.47857087
36ABL21.42720461
37SRPK11.42537146
38NEK91.40195911
39BRD41.34747597
40LATS21.34283507
41SCYL21.28370599
42WEE11.27075047
43MAP3K71.25128742
44KDR1.24121189
45JAK21.22488880
46PRKAA21.22390807
47ERBB21.22125062
48MAP3K101.20135244
49AKT31.18733756
50MAPKAPK51.12361779
51GRK61.10925535
52EIF2AK11.10622022
53CAMKK21.05417913
54JAK11.04536912
55BMPR21.03885376
56TBK10.99043157
57MET0.98753951
58MAPK40.98196487
59PINK10.97095869
60BRSK10.96001845
61AURKB0.95570011
62MAP3K140.92004038
63MAP2K30.89889768
64STK38L0.89814024
65PRKCZ0.88809509
66CDK60.83119930
67MAP3K30.82198597
68RIPK10.81432248
69CAMK1D0.80504434
70EPHB10.79416576
71PRKACG0.77545804
72MAP2K60.76421030
73ZAK0.75291642
74PRKAA10.74231388
75NME20.73212978
76CAMK2G0.72725870
77EPHA30.72431460
78ATR0.70572452
79CHEK20.69642413
80GSK3A0.69234761
81DYRK1B0.67861147
82MAPK150.67778099
83CSK0.67699600
84MAP3K110.67662310
85MAPK120.67528636
86NEK20.66852581
87FGFR30.65587828
88PIM20.64072474
89SGK30.63766422
90TIE10.63028843
91PIM10.62876140
92EIF2AK30.62136962
93RAF10.61133682
94LMTK20.58801286
95PRPF4B0.58327703
96CHEK10.57819691
97PTK20.57450501
98PBK0.57072767
99STK110.55522137
100CSF1R0.55391241
101CDK70.54467787
102GRK10.53630171
103IRAK30.53629968
104AKT20.53586125
105FER0.53133399
106ERBB30.52902447
107PLK10.52312479
108RPS6KB10.51987580
109TGFBR20.51778499
110MAPK70.51357486
111CSNK1G10.51265715
112PRKCQ0.51161831
113CCNB10.50107382
114IKBKE0.50070135
115CSNK1E0.49365668
116PDPK10.48686502
117TTN0.46686989
118CDK20.46528684
119YES10.46178148
120BUB10.45289045
121SGK20.45259029
122IGF1R0.45094172
123RPS6KA50.45034821
124RET0.43125078
125CDK10.42541651
126CDK40.42391132
127BMPR1B0.42028081
128MAP3K50.41740462
129MAP2K10.41361590
130ATM0.40362765
131NUAK10.37906424
132PKN10.37606049
133MELK0.37486418
134SMG10.37454224
135EPHA40.37147632
136MAP3K20.35945722
137MAPK100.35877593
138MAP3K130.35855266
139PAK40.35085069
140ICK0.35066192
141MTOR0.34849763
142AURKA0.34528668
143PIK3CA0.33345589
144EGFR0.32944068
145PRKG20.32656043
146TAOK20.32511408
147PRKCG0.32219206
148TGFBR10.32198887
149MAP2K20.32059214
150CDK80.31421136
151PDK10.31116429
152MAPK140.30357065
153SGK2230.28921094
154SGK4940.28921094
155PRKDC0.28711315
156GSK3B0.28169211
157PDK30.27551394
158PDK40.27551394
159MAP3K60.27399256
160PRKCA0.27151904
161CSNK1G20.26763298
162CAMK40.26653318
163ALK0.26538607
164STK30.26481082
165CAMK1G0.25585440
166MAP3K10.25466281
167TLK10.24852154
168CSNK2A20.22814057
169RPS6KA10.22590986

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.54105434
2Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.55702408
3Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.47681865
4* Arginine biosynthesis_Homo sapiens_hsa002203.03649816
5Complement and coagulation cascades_Homo sapiens_hsa046102.81268864
6Tryptophan metabolism_Homo sapiens_hsa003802.73451478
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.65142250
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.63252600
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.59389340
10Fatty acid degradation_Homo sapiens_hsa000712.51154649
11Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.38152662
12* Nitrogen metabolism_Homo sapiens_hsa009102.33392072
13Pentose and glucuronate interconversions_Homo sapiens_hsa000402.33282846
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.17266286
15Butanoate metabolism_Homo sapiens_hsa006502.12517999
16Peroxisome_Homo sapiens_hsa041462.04924247
17Histidine metabolism_Homo sapiens_hsa003401.99755933
18Chemical carcinogenesis_Homo sapiens_hsa052041.96034625
19Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.93958073
20Steroid hormone biosynthesis_Homo sapiens_hsa001401.93916137
21Propanoate metabolism_Homo sapiens_hsa006401.92886308
22PPAR signaling pathway_Homo sapiens_hsa033201.86028168
23Caffeine metabolism_Homo sapiens_hsa002321.82023645
24Staphylococcus aureus infection_Homo sapiens_hsa051501.80459546
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.79760322
26Fatty acid metabolism_Homo sapiens_hsa012121.78727819
27beta-Alanine metabolism_Homo sapiens_hsa004101.75054616
28Retinol metabolism_Homo sapiens_hsa008301.71469621
29Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.67603408
30* Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.67460258
31Selenocompound metabolism_Homo sapiens_hsa004501.66360872
32Phenylalanine metabolism_Homo sapiens_hsa003601.61783448
332-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.57490300
34Bile secretion_Homo sapiens_hsa049761.56565985
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.53806833
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.52310259
37Tyrosine metabolism_Homo sapiens_hsa003501.45111196
38Sulfur metabolism_Homo sapiens_hsa009201.41279031
39Pyruvate metabolism_Homo sapiens_hsa006201.37844882
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.37529992
41Starch and sucrose metabolism_Homo sapiens_hsa005001.36607962
42Fat digestion and absorption_Homo sapiens_hsa049751.29731462
43Fatty acid elongation_Homo sapiens_hsa000621.29160538
44ABC transporters_Homo sapiens_hsa020101.28600513
45Steroid biosynthesis_Homo sapiens_hsa001001.24251399
46DNA replication_Homo sapiens_hsa030301.24224347
47Folate biosynthesis_Homo sapiens_hsa007901.21803277
48* Biosynthesis of amino acids_Homo sapiens_hsa012301.19838972
49* Carbon metabolism_Homo sapiens_hsa012001.11072672
50Maturity onset diabetes of the young_Homo sapiens_hsa049501.09700699
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04943790
52Non-homologous end-joining_Homo sapiens_hsa034501.04668111
53Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.02009923
54Arginine and proline metabolism_Homo sapiens_hsa003301.01317875
55Cyanoamino acid metabolism_Homo sapiens_hsa004601.00495480
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.98641635
57Vitamin digestion and absorption_Homo sapiens_hsa049770.96070737
58Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.91809680
59Vitamin B6 metabolism_Homo sapiens_hsa007500.90404165
60Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88639470
61Sulfur relay system_Homo sapiens_hsa041220.87911290
62Mismatch repair_Homo sapiens_hsa034300.86892971
63Lysine degradation_Homo sapiens_hsa003100.84915780
64One carbon pool by folate_Homo sapiens_hsa006700.79447611
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74618897
66Glycerolipid metabolism_Homo sapiens_hsa005610.70750040
67Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.69226703
68Glutathione metabolism_Homo sapiens_hsa004800.67683932
69Pentose phosphate pathway_Homo sapiens_hsa000300.62653486
70Fatty acid biosynthesis_Homo sapiens_hsa000610.57564272
71Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.53386522
72RNA transport_Homo sapiens_hsa030130.52004017
73Cell cycle_Homo sapiens_hsa041100.50642828
74Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.48018634
75* Metabolic pathways_Homo sapiens_hsa011000.46436913
76Nucleotide excision repair_Homo sapiens_hsa034200.43800340
77TGF-beta signaling pathway_Homo sapiens_hsa043500.39371926
78Small cell lung cancer_Homo sapiens_hsa052220.39343467
79Prion diseases_Homo sapiens_hsa050200.32548699
80Galactose metabolism_Homo sapiens_hsa000520.32381937
81Fructose and mannose metabolism_Homo sapiens_hsa000510.29582658
82Purine metabolism_Homo sapiens_hsa002300.29421640
83Insulin resistance_Homo sapiens_hsa049310.24416418
84alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.24023375
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.22391480
86Linoleic acid metabolism_Homo sapiens_hsa005910.20481328
87N-Glycan biosynthesis_Homo sapiens_hsa005100.19592449
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.18385607
89Pyrimidine metabolism_Homo sapiens_hsa002400.18275262
90Fanconi anemia pathway_Homo sapiens_hsa034600.17901088
91Glycerophospholipid metabolism_Homo sapiens_hsa005640.16205198
92Protein digestion and absorption_Homo sapiens_hsa049740.15794525
93Thyroid cancer_Homo sapiens_hsa052160.11988199
94Glucagon signaling pathway_Homo sapiens_hsa049220.10327203
95Spliceosome_Homo sapiens_hsa030400.10130609
96Base excision repair_Homo sapiens_hsa034100.09501300
97Other glycan degradation_Homo sapiens_hsa005110.09059190
98AMPK signaling pathway_Homo sapiens_hsa041520.03198749
99Amoebiasis_Homo sapiens_hsa05146-0.2441306
100Bladder cancer_Homo sapiens_hsa05219-0.2413963
101Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.2409626
102Longevity regulating pathway - multiple species_Homo sapiens_hsa04213-0.2373667
103Mineral absorption_Homo sapiens_hsa04978-0.2124763
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1932462
105Regulation of autophagy_Homo sapiens_hsa04140-0.1823174
106Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1751982
107Glycosaminoglycan degradation_Homo sapiens_hsa00531-0.1746114
108Arachidonic acid metabolism_Homo sapiens_hsa00590-0.1685950
109Hepatitis C_Homo sapiens_hsa05160-0.1579549
110African trypanosomiasis_Homo sapiens_hsa05143-0.1547361
111Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.1447158
112Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.1381475
113Systemic lupus erythematosus_Homo sapiens_hsa05322-0.1364554
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1082887
115Renin-angiotensin system_Homo sapiens_hsa04614-0.1038270
116Insulin signaling pathway_Homo sapiens_hsa04910-0.0925678
117Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0753077
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932-0.0508394
119Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0428238

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