CPSF1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cleavage and polyadenylation specificity factor (CPSF) is a multisubunit complex that plays a central role in 3-prime processing of pre-mRNAs. CPSF recognizes the AAUAAA signal in the pre-mRNA and interacts with other proteins to facilitate both RNA cleavage and poly(A) synthesis. CPSF1 is the largest subunit of the CPSF complex (Murthy and Manley, 1995 [PubMed 7590244]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)7.68936082
2transcription from mitochondrial promoter (GO:0006390)5.99006750
3embryonic process involved in female pregnancy (GO:0060136)5.94519013
4replication fork processing (GO:0031297)5.65049856
5proline metabolic process (GO:0006560)5.55331192
6establishment of apical/basal cell polarity (GO:0035089)5.36425748
7negative regulation of erythrocyte differentiation (GO:0045647)5.35016433
8regulation of translational fidelity (GO:0006450)5.11544764
9maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.00678133
10somatic hypermutation of immunoglobulin genes (GO:0016446)4.83334559
11somatic diversification of immune receptors via somatic mutation (GO:0002566)4.83334559
12DNA deamination (GO:0045006)4.75878722
13mitotic G1 DNA damage checkpoint (GO:0031571)4.68963364
14negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.64380289
15mannose metabolic process (GO:0006013)4.63119794
16positive regulation of protein homooligomerization (GO:0032464)4.62380678
17mitochondrial DNA metabolic process (GO:0032042)4.58554706
18regulation of integrin activation (GO:0033623)4.55055415
19spliceosomal tri-snRNP complex assembly (GO:0000244)4.54405230
20establishment or maintenance of monopolar cell polarity (GO:0061339)4.52829086
21establishment of monopolar cell polarity (GO:0061162)4.52829086
22dosage compensation (GO:0007549)4.51790377
23oxidative demethylation (GO:0070989)4.51323919
24DNA strand renaturation (GO:0000733)4.42489940
25formation of translation preinitiation complex (GO:0001731)4.37504007
26activation of Rac GTPase activity (GO:0032863)4.31827567
27planar cell polarity pathway involved in neural tube closure (GO:0090179)4.21707354
28telomere maintenance via semi-conservative replication (GO:0032201)4.18605836
29negative regulation of cell size (GO:0045792)4.17587273
30mitotic G1/S transition checkpoint (GO:0044819)4.08486061
31base-excision repair (GO:0006284)4.07458655
32Golgi transport vesicle coating (GO:0048200)4.07454002
33COPI coating of Golgi vesicle (GO:0048205)4.07454002
34regulation of protein homooligomerization (GO:0032462)4.07324429
35G1 DNA damage checkpoint (GO:0044783)4.03662715
36negative regulation of mRNA processing (GO:0050686)4.02340128
37viral mRNA export from host cell nucleus (GO:0046784)4.01378418
38DNA strand elongation involved in DNA replication (GO:0006271)4.00333036
39poly(A)+ mRNA export from nucleus (GO:0016973)3.95896865
40negative regulation of RNA splicing (GO:0033119)3.81376137
41regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.81181915
42DNA topological change (GO:0006265)3.78424087
43DNA strand elongation (GO:0022616)3.77787371
44pre-miRNA processing (GO:0031054)3.76678946
45embryonic placenta development (GO:0001892)3.72861151
46nucleotide-excision repair, DNA gap filling (GO:0006297)3.72704340
47protein retention in ER lumen (GO:0006621)3.70404325
48regulation of sister chromatid cohesion (GO:0007063)3.68500907
49histone H4-K12 acetylation (GO:0043983)3.66867008
50regulation of histone H3-K27 methylation (GO:0061085)3.64810477
51semaphorin-plexin signaling pathway (GO:0071526)3.64379933
52regulation of RNA export from nucleus (GO:0046831)3.59234959
53DNA unwinding involved in DNA replication (GO:0006268)3.59156581
54negative regulation of cell cycle arrest (GO:0071157)3.58896625
55maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.54401422
56regulation of posttranscriptional gene silencing (GO:0060147)3.54031628
57regulation of gene silencing by miRNA (GO:0060964)3.54031628
58regulation of gene silencing by RNA (GO:0060966)3.54031628
59adherens junction assembly (GO:0034333)3.54002966
60mitotic sister chromatid segregation (GO:0000070)3.53728761
61regulation of DNA damage checkpoint (GO:2000001)3.50600775
62regulation of mammary gland epithelial cell proliferation (GO:0033599)3.49918671
63positive regulation of mitotic sister chromatid separation (GO:1901970)3.49606562
64positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.49606562
65positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.49606562
66focal adhesion assembly (GO:0048041)3.47535590
67cell-substrate adherens junction assembly (GO:0007045)3.47535590
68histone H4 deacetylation (GO:0070933)3.47434500
69telomere maintenance via recombination (GO:0000722)3.46229357
70positive regulation by host of viral transcription (GO:0043923)3.46214398
71negative regulation of mRNA metabolic process (GO:1903312)3.41925203
72apoptotic process involved in morphogenesis (GO:0060561)3.38795081
73trophectodermal cell differentiation (GO:0001829)3.37297157
74maternal placenta development (GO:0001893)3.36903944
75nucleosome disassembly (GO:0006337)3.36815578
76protein-DNA complex disassembly (GO:0032986)3.36815578
773-UTR-mediated mRNA stabilization (GO:0070935)3.35215404
78mitotic nuclear envelope disassembly (GO:0007077)3.35063367
79nodal signaling pathway (GO:0038092)3.34323271
80double-strand break repair via nonhomologous end joining (GO:0006303)3.27010197
81non-recombinational repair (GO:0000726)3.27010197
82meiotic chromosome segregation (GO:0045132)3.26731627
83DNA duplex unwinding (GO:0032508)3.26608755
84mitochondrial RNA metabolic process (GO:0000959)3.26183217
85regulation of nucleobase-containing compound transport (GO:0032239)3.26102118
86sister chromatid segregation (GO:0000819)3.24195188
87DNA geometric change (GO:0032392)3.23954162
88retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.20817511
89positive regulation of chromosome segregation (GO:0051984)3.19681157
90negative regulation of JAK-STAT cascade (GO:0046426)3.18029984
91mitotic recombination (GO:0006312)3.15854764
92mitotic chromosome condensation (GO:0007076)3.15846643
93folic acid-containing compound biosynthetic process (GO:0009396)3.11300639
94heterochromatin organization (GO:0070828)3.09344243
95nuclear envelope disassembly (GO:0051081)3.08656984
96membrane disassembly (GO:0030397)3.08656984
97regulation of ARF GTPase activity (GO:0032312)3.07806928
98atrioventricular valve morphogenesis (GO:0003181)3.07390348
99* termination of RNA polymerase II transcription (GO:0006369)3.06408455
100determination of adult lifespan (GO:0008340)3.05950904
101regulation of double-strand break repair (GO:2000779)3.04527363
102base-excision repair, AP site formation (GO:0006285)3.04303495
103cellular response to epidermal growth factor stimulus (GO:0071364)3.03846243
104regulation of chromatin binding (GO:0035561)3.03665975
105regulation of double-strand break repair via homologous recombination (GO:0010569)3.03486802
106positive regulation of histone deacetylation (GO:0031065)3.01184765
107regulation of NFAT protein import into nucleus (GO:0051532)3.00720099
108negative regulation of fatty acid biosynthetic process (GO:0045717)3.00177778
109cell-cell junction maintenance (GO:0045217)3.00169466
110pentose-phosphate shunt (GO:0006098)3.00113647
111telomere maintenance via telomere lengthening (GO:0010833)3.00097558
112RNA stabilization (GO:0043489)2.97441269
113mRNA stabilization (GO:0048255)2.97441269
114glutamine family amino acid biosynthetic process (GO:0009084)2.97277953
115intracellular estrogen receptor signaling pathway (GO:0030520)2.96173324
116DNA double-strand break processing (GO:0000729)2.92651183
117positive regulation of protein oligomerization (GO:0032461)2.91931435
118cytoskeletal anchoring at plasma membrane (GO:0007016)2.91734647
119cellular response to zinc ion (GO:0071294)2.90795482
120positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.89088824
121cell-substrate junction assembly (GO:0007044)2.87862267
122protein localization to kinetochore (GO:0034501)2.87660110
123positive regulation of Cdc42 GTPase activity (GO:0043089)2.85842661
124regulation of glucose import in response to insulin stimulus (GO:2001273)2.84531464
125DNA integration (GO:0015074)2.83869354
126epithelial cell differentiation involved in prostate gland development (GO:0060742)2.83578425
127negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.82920479
128anatomical structure regression (GO:0060033)2.82659220
129DNA replication initiation (GO:0006270)2.81709406
130peptidyl-arginine omega-N-methylation (GO:0035247)2.81059192
131* mRNA transport (GO:0051028)2.80864673
132histone arginine methylation (GO:0034969)2.80562555
133regulation of early endosome to late endosome transport (GO:2000641)2.80310074
134regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.79422540
135apoptotic process involved in development (GO:1902742)2.78798420
136negative regulation of protein oligomerization (GO:0032460)2.78385226
137kinetochore assembly (GO:0051382)2.78133288
138embryonic camera-type eye development (GO:0031076)2.77776869
139snRNA metabolic process (GO:0016073)2.77471859
140glucose catabolic process (GO:0006007)2.77168311
141negative regulation of viral release from host cell (GO:1902187)2.76760574
142nuclear envelope organization (GO:0006998)2.75649881
143basement membrane organization (GO:0071711)2.75467279
144negative regulation of fatty acid transport (GO:2000192)2.75165383
145histone H3 deacetylation (GO:0070932)2.74683779
146activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.74677582
147DNA demethylation (GO:0080111)2.74411100
148convergent extension (GO:0060026)2.74369815
149maturation of 5.8S rRNA (GO:0000460)2.74242446
150epithelial cell-cell adhesion (GO:0090136)2.72241077
151positive regulation of nuclease activity (GO:0032075)2.70063401
152positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.67547632
153thymic T cell selection (GO:0045061)2.65795474
154modulation by virus of host process (GO:0019054)2.64050753
155activation of JUN kinase activity (GO:0007257)2.63571218
156positive regulation of blood vessel endothelial cell migration (GO:0043536)2.57982339
157response to epidermal growth factor (GO:0070849)2.56948355
158NADPH regeneration (GO:0006740)2.53676357
159positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.52256782
160regulation of extracellular matrix disassembly (GO:0010715)2.52194058
161negative regulation of myotube differentiation (GO:0010832)2.51424814
162pinocytosis (GO:0006907)2.50351535
163nuclear pore complex assembly (GO:0051292)2.49480070
164glucose 6-phosphate metabolic process (GO:0051156)2.49297180
165protein localization to endosome (GO:0036010)2.48888653
166histone H3-K36 demethylation (GO:0070544)2.48860163
167positive regulation of receptor recycling (GO:0001921)2.48584274
168stress granule assembly (GO:0034063)2.48469396
169Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.47443006
170developmental programmed cell death (GO:0010623)2.47367165
171peptidyl-lysine dimethylation (GO:0018027)2.45249239
172UV protection (GO:0009650)2.44874449
173modulation by symbiont of host cellular process (GO:0044068)2.44312177
174regulation of cholesterol homeostasis (GO:2000188)2.43587417
175insulin-like growth factor receptor signaling pathway (GO:0048009)2.43510470
176snRNA processing (GO:0016180)2.41490036
177response to laminar fluid shear stress (GO:0034616)2.40977693
178protein export from nucleus (GO:0006611)2.40976277
179regulation of nuclease activity (GO:0032069)2.40633542
180retrograde transport, endosome to Golgi (GO:0042147)2.40461432
181histone H3-K9 demethylation (GO:0033169)2.37891013
182stress fiber assembly (GO:0043149)2.35829910

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.87450436
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.44603883
3* MYC_18555785_ChIP-Seq_MESCs_Mouse3.03750997
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.95296721
5MYC_22102868_ChIP-Seq_BL_Human2.71832125
6TP63_17297297_ChIP-ChIP_HaCaT_Human2.61068392
7SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.60737676
8THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.53074932
9ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.48053879
10* VDR_21846776_ChIP-Seq_THP-1_Human2.46887642
11MYC_19079543_ChIP-ChIP_MESCs_Mouse2.45811350
12TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.30680389
13FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.21494210
14E2F4_17652178_ChIP-ChIP_JURKAT_Human2.14519367
15RARG_19884340_ChIP-ChIP_MEFs_Mouse2.10456443
16* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.09333269
17KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.08261615
18KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.08261615
19KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.08261615
20* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.98395465
21* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.87260139
22POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79187603
23SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.77769471
24KDM2B_26808549_Chip-Seq_K562_Human1.77326527
25* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.75396585
26STAT3_1855785_ChIP-Seq_MESCs_Mouse1.74159132
27NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.71394856
28EGR1_19374776_ChIP-ChIP_THP-1_Human1.70604009
29P68_20966046_ChIP-Seq_HELA_Human1.68431097
30SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.61718134
31STAT6_21828071_ChIP-Seq_BEAS2B_Human1.60672858
32NANOG_18555785_ChIP-Seq_MESCs_Mouse1.60435398
33NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.59657061
34LXR_22292898_ChIP-Seq_THP-1_Human1.59367039
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.57219591
36CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.55887468
37NELFA_20434984_ChIP-Seq_ESCs_Mouse1.54646520
38VDR_24763502_ChIP-Seq_THP-1_Human1.53875935
39NANOG_21062744_ChIP-ChIP_HESCs_Human1.53435458
40XRN2_22483619_ChIP-Seq_HELA_Human1.53091690
41NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.52745585
42* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.52415484
43CTCF_27219007_Chip-Seq_ERYTHROID_Human1.52045686
44POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.51882838
45ESR1_15608294_ChIP-ChIP_MCF-7_Human1.51788359
46* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.51085482
47POU5F1_16518401_ChIP-PET_MESCs_Mouse1.51003661
48KLF4_18555785_ChIP-Seq_MESCs_Mouse1.49295172
49NCOR1_26117541_ChIP-Seq_K562_Human1.48061792
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.47954690
51E2F1_21310950_ChIP-Seq_MCF-7_Human1.46760483
52SA1_27219007_Chip-Seq_ERYTHROID_Human1.46044935
53KDM2B_26808549_Chip-Seq_JURKAT_Human1.45809494
54* ERG_21242973_ChIP-ChIP_JURKAT_Human1.44686618
55THAP11_20581084_ChIP-Seq_MESCs_Mouse1.43571014
56KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43006555
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.42954095
58NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.42356317
59SMC4_20622854_ChIP-Seq_HELA_Human1.42179600
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.41445713
61CREB1_26743006_Chip-Seq_LNCaP_Human1.40326570
62KDM2B_26808549_Chip-Seq_DND41_Human1.40032351
63TCF3_18692474_ChIP-Seq_MESCs_Mouse1.38260907
64KDM5A_27292631_Chip-Seq_BREAST_Human1.37957898
65TCF3_18692474_ChIP-Seq_MEFs_Mouse1.37510659
66ETS1_20019798_ChIP-Seq_JURKAT_Human1.37320316
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.37263943
68* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37198813
69KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.37148996
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36035490
71* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.35745628
72MAF_26560356_Chip-Seq_TH2_Human1.35335852
73TCF7_22412390_ChIP-Seq_EML_Mouse1.33484304
74SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.32398965
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.32066134
76WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.31566652
77RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.30789511
78MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.30478261
79ELK3_25401928_ChIP-Seq_HUVEC_Human1.29994322
80CLOCK_20551151_ChIP-Seq_293T_Human1.29602112
81* GABP_19822575_ChIP-Seq_HepG2_Human1.29064142
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.28973934
83ESR2_21235772_ChIP-Seq_MCF-7_Human1.28956449
84SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.28854529
85P300_27058665_Chip-Seq_ZR-75-30cells_Human1.28170915
86* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.27689021
87HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.27607675
88ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.25792527
89ZNF263_19887448_ChIP-Seq_K562_Human1.25720715
90SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.25122103
91ZFP281_18757296_ChIP-ChIP_E14_Mouse1.25111718
92* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.24401497
93RUNX1_27514584_Chip-Seq_MCF-7_Human1.24299409
94RUNX1_22412390_ChIP-Seq_EML_Mouse1.23073851
95DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.22932569
96KDM2B_26808549_Chip-Seq_SUP-B15_Human1.22757367
97TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.22477414
98STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.22407846
99PU.1_20513432_ChIP-Seq_Bcells_Mouse1.22144089
100* ELF1_20517297_ChIP-Seq_JURKAT_Human1.21648320
101CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.21115575
102YY1_21170310_ChIP-Seq_MESCs_Mouse1.20111347
103KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.19261982
104ZFP281_27345836_Chip-Seq_ESCs_Mouse1.18957494
105SRY_22984422_ChIP-ChIP_TESTIS_Rat1.18897233
106* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18672305
107TP53_22127205_ChIP-Seq_IMR90_Human1.17752023
108RACK7_27058665_Chip-Seq_MCF-7_Human1.17408987
109GATA1_22383799_ChIP-Seq_G1ME_Mouse1.17346763
110ATF3_27146783_Chip-Seq_COLON_Human1.15515600
111DCP1A_22483619_ChIP-Seq_HELA_Human1.15230972
112SOX2_18555785_ChIP-Seq_MESCs_Mouse1.14403249
113MAF_26560356_Chip-Seq_TH1_Human1.11620684
114TET1_21451524_ChIP-Seq_MESCs_Mouse1.11427321
115POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.10902015
116CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.10680803
117BCOR_27268052_Chip-Seq_Bcells_Human1.09774697
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.08912034
119UTX_26944678_Chip-Seq_JUKART_Human1.08673385
120BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08628981
121TFEB_21752829_ChIP-Seq_HELA_Human1.08577547
122NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.08439101
123CIITA_25753668_ChIP-Seq_RAJI_Human1.08406272
124POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.07874076
125DNAJC2_21179169_ChIP-ChIP_NT2_Human1.07263539
126CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.07130008
127NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.06724193
128* TTF2_22483619_ChIP-Seq_HELA_Human1.06676964
129SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.06384376
130SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.05354365
131ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.04706219
132RARB_24833708_ChIP-Seq_LIVER_Mouse1.04013305
133ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.03849950
134CTCF_27219007_Chip-Seq_Bcells_Human1.03649433
135SOX2_18692474_ChIP-Seq_MESCs_Mouse1.02859367
136MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.02548844
137* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01945706
138BCL6_27268052_Chip-Seq_Bcells_Human1.01512398
139OCT4_18692474_ChIP-Seq_MEFs_Mouse1.01142864
140MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.01025031
141CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.99694243
142PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99529928
143TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.99215592
144RARA_24833708_ChIP-Seq_LIVER_Mouse0.97959691
145SOX2_18692474_ChIP-Seq_MEFs_Mouse0.97465016
146E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.97383109
147CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97250928
148EST1_17652178_ChIP-ChIP_JURKAT_Human0.97117045
149RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.97064255
150SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.96649741
151AR_21909140_ChIP-Seq_LNCAP_Human0.96202872
152SCL_19346495_ChIP-Seq_HPC-7_Human0.93657776
153PHF8_20622854_ChIP-Seq_HELA_Human0.93260023
154DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.92597266

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.43712430
2MP0009278_abnormal_bone_marrow3.90286076
3MP0010094_abnormal_chromosome_stability3.33148106
4MP0010030_abnormal_orbit_morphology3.01693871
5MP0003111_abnormal_nucleus_morphology2.84630401
6MP0004957_abnormal_blastocyst_morpholog2.72953966
7MP0005451_abnormal_body_composition2.57179174
8MP0004233_abnormal_muscle_weight2.54604380
9MP0010352_gastrointestinal_tract_polyps2.52977141
10MP0003693_abnormal_embryo_hatching2.46365752
11MP0005076_abnormal_cell_differentiation2.45601640
12MP0003077_abnormal_cell_cycle2.39017360
13MP0005409_darkened_coat_color2.36165992
14MP0005397_hematopoietic_system_phenotyp2.16888796
15MP0001545_abnormal_hematopoietic_system2.16888796
16MP0003890_abnormal_embryonic-extraembry2.16334206
17MP0008058_abnormal_DNA_repair2.13401766
18MP0008995_early_reproductive_senescence2.11571031
19MP0008260_abnormal_autophagy2.04773995
20MP0002653_abnormal_ependyma_morphology2.04421799
21MP0000678_abnormal_parathyroid_gland2.01011810
22MP0003786_premature_aging2.00262930
23MP0003283_abnormal_digestive_organ1.94697399
24MP0001730_embryonic_growth_arrest1.90745985
25MP0004185_abnormal_adipocyte_glucose1.90047195
26MP0000566_synostosis1.87630066
27MP0002086_abnormal_extraembryonic_tissu1.86576868
28MP0008877_abnormal_DNA_methylation1.86526201
29MP0002084_abnormal_developmental_patter1.86209167
30MP0001697_abnormal_embryo_size1.85087879
31MP0004197_abnormal_fetal_growth/weight/1.84596311
32MP0004133_heterotaxia1.83967611
33MP0010234_abnormal_vibrissa_follicle1.82763635
34MP0004858_abnormal_nervous_system1.81896687
35MP0005171_absent_coat_pigmentation1.80161198
36MP0002396_abnormal_hematopoietic_system1.75820283
37MP0000350_abnormal_cell_proliferation1.75798297
38MP0005380_embryogenesis_phenotype1.73747461
39MP0001672_abnormal_embryogenesis/_devel1.73747461
40MP0003119_abnormal_digestive_system1.73634714
41MP0002089_abnormal_postnatal_growth/wei1.72132742
42MP0002085_abnormal_embryonic_tissue1.71637636
43MP0008932_abnormal_embryonic_tissue1.67736117
44MP0010307_abnormal_tumor_latency1.67491236
45MP0002009_preneoplasia1.65549684
46MP0000490_abnormal_crypts_of1.65025356
47MP0002877_abnormal_melanocyte_morpholog1.64939984
48MP0001293_anophthalmia1.60096914
49MP0001348_abnormal_lacrimal_gland1.57749313
50MP0003984_embryonic_growth_retardation1.52997287
51MP0000003_abnormal_adipose_tissue1.51696219
52MP0001873_stomach_inflammation1.50623450
53MP0002088_abnormal_embryonic_growth/wei1.49828402
54MP0003705_abnormal_hypodermis_morpholog1.49627990
55MP0008438_abnormal_cutaneous_collagen1.48063652
56MP0005666_abnormal_adipose_tissue1.46551695
57MP0002080_prenatal_lethality1.45310479
58MP0005174_abnormal_tail_pigmentation1.43121557
59MP0009672_abnormal_birth_weight1.42860859
60MP0003567_abnormal_fetal_cardiomyocyte1.42116366
61MP0003091_abnormal_cell_migration1.41057295
62MP0000751_myopathy1.36331615
63MP0000371_diluted_coat_color1.34666712
64MP0005375_adipose_tissue_phenotype1.32877071
65MP0003172_abnormal_lysosome_physiology1.32841982
66MP0003436_decreased_susceptibility_to1.32800053
67MP0004381_abnormal_hair_follicle1.32704699
68MP0002019_abnormal_tumor_incidence1.30901789
69MP0002060_abnormal_skin_morphology1.29409825
70MP0002249_abnormal_larynx_morphology1.28025214
71MP0004947_skin_inflammation1.26114959
72MP0004264_abnormal_extraembryonic_tissu1.24926207
73MP0003453_abnormal_keratinocyte_physiol1.23089484
74MP0000858_altered_metastatic_potential1.18359112
75MP0003300_gastrointestinal_ulcer1.18187281
76MP0002269_muscular_atrophy1.18125541
77MP0002254_reproductive_system_inflammat1.15614728
78MP0005075_abnormal_melanosome_morpholog1.15595003
79MP0008007_abnormal_cellular_replicative1.14014639
80MP0003279_aneurysm1.13819928
81MP0009840_abnormal_foam_cell1.13797516
82MP0000313_abnormal_cell_death1.12206449
83MP0002282_abnormal_trachea_morphology1.12188006
84MP0009931_abnormal_skin_appearance1.09697735
85MP0005621_abnormal_cell_physiology1.09678004
86MP0000733_abnormal_muscle_development1.09307489
87MP0003115_abnormal_respiratory_system1.08126160
88MP0009384_cardiac_valve_regurgitation1.06356379
89MP0002111_abnormal_tail_morphology1.06278935
90MP0003566_abnormal_cell_adhesion1.05485805
91MP0000685_abnormal_immune_system1.05419366
92MP0009053_abnormal_anal_canal1.02170041
93MP0004272_abnormal_basement_membrane1.01958718
94MP0005257_abnormal_intraocular_pressure1.01013680
95MP0003763_abnormal_thymus_physiology0.99884143
96MP0000703_abnormal_thymus_morphology0.95472115
97MP0004808_abnormal_hematopoietic_stem0.94333114
98MP0005023_abnormal_wound_healing0.93407647
99MP0000689_abnormal_spleen_morphology0.91964878
100MP0003385_abnormal_body_wall0.91030814
101MP0003303_peritoneal_inflammation0.90647980
102MP0006072_abnormal_retinal_apoptosis0.90010396
103MP0003191_abnormal_cellular_cholesterol0.89358062
104MP0006138_congestive_heart_failure0.88316855
105MP0002933_joint_inflammation0.88195723
106MP0001216_abnormal_epidermal_layer0.87661205
107MP0009333_abnormal_splenocyte_physiolog0.86868431
108MP0002075_abnormal_coat/hair_pigmentati0.85370019
109MP0005670_abnormal_white_adipose0.85354223
110MP0000470_abnormal_stomach_morphology0.85039105
111MP0002932_abnormal_joint_morphology0.84387328
112MP0010630_abnormal_cardiac_muscle0.84158155
113MP0002398_abnormal_bone_marrow0.83204869
114MP0000767_abnormal_smooth_muscle0.82828619
115MP0003942_abnormal_urinary_system0.80323655
116MP0002405_respiratory_system_inflammati0.79948747
117MP0000579_abnormal_nail_morphology0.79509729
118MP0002722_abnormal_immune_system0.79124397
119MP0001915_intracranial_hemorrhage0.78928803
120MP0000477_abnormal_intestine_morphology0.78907056
121MP0002098_abnormal_vibrissa_morphology0.78069160
122MP0003935_abnormal_craniofacial_develop0.77896253
123MP0002092_abnormal_eye_morphology0.77507480
124MP0000428_abnormal_craniofacial_morphol0.76903951
125MP0005266_abnormal_metabolism0.76197155
126MP0002970_abnormal_white_adipose0.75364076
127MP0001145_abnormal_male_reproductive0.74441682
128MP0002166_altered_tumor_susceptibility0.73964739
129MP0005384_cellular_phenotype0.73367583
130MP0002925_abnormal_cardiovascular_devel0.71210978
131MP0002697_abnormal_eye_size0.70556521
132MP0003123_paternal_imprinting0.70461146
133MP0001958_emphysema0.69874159
134MP0009115_abnormal_fat_cell0.69173035
135MP0005501_abnormal_skin_physiology0.67360310
136MP0000462_abnormal_digestive_system0.66600864
137MP0002796_impaired_skin_barrier0.66042113
138MP0003806_abnormal_nucleotide_metabolis0.65417656
139MP0001849_ear_inflammation0.64160529
140MP0003828_pulmonary_edema0.63161211
141MP0000266_abnormal_heart_morphology0.62232885
142MP0003943_abnormal_hepatobiliary_system0.62154775
143MP0002114_abnormal_axial_skeleton0.62113434
144MP0008770_decreased_survivor_rate0.61944622
145MP0005058_abnormal_lysosome_morphology0.61551214
146MP0002210_abnormal_sex_determination0.61496241
147MP0000467_abnormal_esophagus_morphology0.60437603
148MP0000537_abnormal_urethra_morphology0.60300948

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)4.71971232
2Facial hemangioma (HP:0000329)4.31841767
3Poikiloderma (HP:0001029)4.04010974
4Annular pancreas (HP:0001734)4.03283397
5Pustule (HP:0200039)4.02967415
6Intestinal fistula (HP:0100819)3.80932706
7Ulnar bowing (HP:0003031)3.80480178
8Rectal fistula (HP:0100590)3.79217362
9Rectovaginal fistula (HP:0000143)3.79217362
10Hyperacusis (HP:0010780)3.70306586
11Selective tooth agenesis (HP:0001592)3.51087380
12Basal cell carcinoma (HP:0002671)3.45628633
13Ependymoma (HP:0002888)3.43106339
14Vaginal fistula (HP:0004320)3.40481850
15Turricephaly (HP:0000262)3.35771650
16Short humerus (HP:0005792)3.33349128
17Hypochromic microcytic anemia (HP:0004840)3.29908110
18Broad face (HP:0000283)3.28665741
19Astrocytoma (HP:0009592)3.25336532
20Abnormality of the astrocytes (HP:0100707)3.25336532
21Cervical subluxation (HP:0003308)3.23952686
22Aplasia/hypoplasia of the humerus (HP:0006507)3.23815766
23Flat acetabular roof (HP:0003180)3.20348846
24Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.20344420
25Orthostatic hypotension (HP:0001278)3.13640039
26Alopecia of scalp (HP:0002293)3.12929231
27Obstructive sleep apnea (HP:0002870)3.11112761
28Tongue fasciculations (HP:0001308)3.07789534
29Concave nail (HP:0001598)3.05867838
30Squamous cell carcinoma (HP:0002860)2.97136365
31Absent radius (HP:0003974)2.94182177
32Disproportionate tall stature (HP:0001519)2.94153907
33Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.92177248
34Vertebral hypoplasia (HP:0008417)2.92177248
35Absent thumb (HP:0009777)2.89643724
36Muscle fibrillation (HP:0010546)2.85586672
37Cerebral aneurysm (HP:0004944)2.85442047
38Patellar aplasia (HP:0006443)2.82744639
39Volvulus (HP:0002580)2.79122224
40Thin bony cortex (HP:0002753)2.76194284
41Absent forearm bone (HP:0003953)2.74720260
42Aplasia involving forearm bones (HP:0009822)2.74720260
43Intestinal atresia (HP:0011100)2.72944469
44Congenital hip dislocation (HP:0001374)2.72502449
45Increased IgM level (HP:0003496)2.70413531
46Abnormality of the thoracic spine (HP:0100711)2.68854269
47Abnormal number of incisors (HP:0011064)2.67312213
48Distal lower limb amyotrophy (HP:0008944)2.62373989
49Protrusio acetabuli (HP:0003179)2.61305574
50Upper limb amyotrophy (HP:0009129)2.58471749
51Distal upper limb amyotrophy (HP:0007149)2.58471749
52Broad alveolar ridges (HP:0000187)2.58002219
53Aplasia/Hypoplasia of the patella (HP:0006498)2.56378963
54Abnormality of the labia minora (HP:0012880)2.55602717
55Thoracic kyphosis (HP:0002942)2.50312853
56Male infertility (HP:0003251)2.47939641
57Pancreatic islet-cell hyperplasia (HP:0004510)2.47619705
58Abnormality of the aortic arch (HP:0012303)2.46505406
59Glioma (HP:0009733)2.44385917
60Anteriorly placed anus (HP:0001545)2.43982832
61Abnormality of the lower motor neuron (HP:0002366)2.43516016
62Coronal craniosynostosis (HP:0004440)2.42552397
63Stridor (HP:0010307)2.42301680
64Thin ribs (HP:0000883)2.40973453
65Neoplasm of the oral cavity (HP:0100649)2.39767441
66Premature rupture of membranes (HP:0001788)2.37337917
67Increased connective tissue (HP:0009025)2.37135453
68Abnormality of male internal genitalia (HP:0000022)2.34275118
69Albinism (HP:0001022)2.34159181
70Biconcave vertebral bodies (HP:0004586)2.30265452
71Reticulocytosis (HP:0001923)2.29949337
72Vertebral fusion (HP:0002948)2.29193802
73Premature graying of hair (HP:0002216)2.28489828
74Spinal muscular atrophy (HP:0007269)2.26908041
75J-shaped sella turcica (HP:0002680)2.26456118
76Shallow orbits (HP:0000586)2.25661804
77Long palpebral fissure (HP:0000637)2.23284435
78Short chin (HP:0000331)2.21400005
79Short 5th finger (HP:0009237)2.19980079
80IgA deficiency (HP:0002720)2.19708558
81Hemorrhage of the eye (HP:0011885)2.18799502
82Bowed forearm bones (HP:0003956)2.18320815
83Bowing of the arm (HP:0006488)2.18320815
84Premature skin wrinkling (HP:0100678)2.17757124
85Insomnia (HP:0100785)2.16734023
86Hypotelorism (HP:0000601)2.16351544
87Abnormal vertebral ossification (HP:0100569)2.15117365
88Abnormality of the fingertips (HP:0001211)2.14841080
89Acute lymphatic leukemia (HP:0006721)2.14364314
90Abnormal hemoglobin (HP:0011902)2.13746660
91Pointed chin (HP:0000307)2.12451692
92Hypochromic anemia (HP:0001931)2.11181984
93Asymmetry of the thorax (HP:0001555)2.10454550
94Dysautonomia (HP:0002459)2.08921987
95Diaphragmatic weakness (HP:0009113)2.08164117
96Missing ribs (HP:0000921)2.07823464
97Large for gestational age (HP:0001520)2.06289919
98Flattened epiphyses (HP:0003071)2.05999257
99Flared metaphyses (HP:0003015)2.05599421
100Fragile skin (HP:0001030)2.02185340
101Medulloblastoma (HP:0002885)2.00917548
102Ankyloglossia (HP:0010296)2.00834787
103Broad palm (HP:0001169)2.00467054
104Alacrima (HP:0000522)2.00437475
105Hamartoma (HP:0010566)2.00268675
106Abnormality of the pancreatic islet cells (HP:0006476)1.98829579
107Abnormality of endocrine pancreas physiology (HP:0012093)1.98829579
108Lymphangioma (HP:0100764)1.96892536
109Heterotopia (HP:0002282)1.96705987
110Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.96382741
111Centrally nucleated skeletal muscle fibers (HP:0003687)1.95187736
112Abnormal gallbladder physiology (HP:0012438)1.95164549
113Cholecystitis (HP:0001082)1.95164549
114Achilles tendon contracture (HP:0001771)1.93577494
115Neoplasm of striated muscle (HP:0009728)1.91998225
116Abnormality of the calcaneus (HP:0008364)1.91710732
117Rhabdomyosarcoma (HP:0002859)1.90874240
118Degeneration of anterior horn cells (HP:0002398)1.89283528
119Abnormality of the anterior horn cell (HP:0006802)1.89283528
120Split hand (HP:0001171)1.88773198
121Mitral regurgitation (HP:0001653)1.88598360
122Broad thumb (HP:0011304)1.88463316
123Cupped ribs (HP:0000887)1.88123684
124Abnormality of the ileum (HP:0001549)1.87892679
125Distal lower limb muscle weakness (HP:0009053)1.85513276
126Vitreoretinal degeneration (HP:0000655)1.85326249
127Abnormality of oral frenula (HP:0000190)1.85315398
128Gastrointestinal atresia (HP:0002589)1.85271051
129Dislocated radial head (HP:0003083)1.85158262
130Mucopolysacchariduria (HP:0008155)1.84894605
131Urinary glycosaminoglycan excretion (HP:0003541)1.84894605
132Urethral obstruction (HP:0000796)1.84104221
133Patellar dislocation (HP:0002999)1.82985524
134Truncus arteriosus (HP:0001660)1.82880729
135Advanced eruption of teeth (HP:0006288)1.82630016
136Polycythemia (HP:0001901)1.82069045
137Metaphyseal cupping (HP:0003021)1.80983716
138Mildly elevated creatine phosphokinase (HP:0008180)1.80728700
139Short 4th metacarpal (HP:0010044)1.80668177
140Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.80668177
141Long eyelashes (HP:0000527)1.79552255
142Growth hormone excess (HP:0000845)1.79079712
143Colitis (HP:0002583)1.78078966
144Capillary hemangiomas (HP:0005306)1.77971946
145Abnormality of the distal phalanx of the thumb (HP:0009617)1.77889570
146Bifid uvula (HP:0000193)1.77884398
147Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.77794962
148Absent epiphyses (HP:0010577)1.77794962
149Bronchomalacia (HP:0002780)1.77418191
150Hypoplasia of the radius (HP:0002984)1.77342628
151Short thumb (HP:0009778)1.77329540
152Abnormality of the lumbar spine (HP:0100712)1.75550303
153Hemivertebrae (HP:0002937)1.75395480
154Cellulitis (HP:0100658)1.74210570
155Broad distal phalanx of finger (HP:0009836)1.74105788
156Joint stiffness (HP:0001387)1.73624092
157Hypotrichosis (HP:0001006)1.73500780
158Cafe-au-lait spot (HP:0000957)1.72387065
159Lower limb amyotrophy (HP:0007210)1.72366705
160Deep venous thrombosis (HP:0002625)1.72330389
161Pseudobulbar signs (HP:0002200)1.72086091
162Abnormality of the radial head (HP:0003995)1.72065572
163Hand muscle atrophy (HP:0009130)1.71424300
164Aneurysm (HP:0002617)1.71084781
165Easy fatigability (HP:0003388)1.71063502
166Hypoplastic ischia (HP:0003175)1.69911691
167Abnormality of the Achilles tendon (HP:0005109)1.69689189
168Deep palmar crease (HP:0006191)1.69250456
169Bowel incontinence (HP:0002607)1.68430885
170Gastrointestinal inflammation (HP:0004386)1.67222113
171Seborrheic dermatitis (HP:0001051)1.66238424
172Blue sclerae (HP:0000592)1.65185318
173Atelectasis (HP:0100750)1.64633628
174Vertebral compression fractures (HP:0002953)1.63898929
175Coxa vara (HP:0002812)1.63656249
176Abdominal distention (HP:0003270)1.62137239
177Mitral valve prolapse (HP:0001634)1.62124514
178Polygenic inheritance (HP:0010982)1.61626410
179Germ cell neoplasia (HP:0100728)1.60913189
180Abnormality of reticulocytes (HP:0004312)1.60791170
181Elfin facies (HP:0004428)1.60789839
182Increased variability in muscle fiber diameter (HP:0003557)1.60625481
183Difficulty climbing stairs (HP:0003551)1.59938862
184Syringomyelia (HP:0003396)1.59339391
185Spinal cord lesions (HP:0100561)1.59339391
186Deviation of the thumb (HP:0009603)1.59335177
187Increased nuchal translucency (HP:0010880)1.58104620
188Bell-shaped thorax (HP:0001591)1.57563055
189Myopathic facies (HP:0002058)1.56144570
190Renal duplication (HP:0000075)1.55789023
191Bladder diverticulum (HP:0000015)1.54361833

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK5.30341504
2SMG13.78793966
3DDR23.63158913
4MAPK153.31885860
5MAP3K63.12525250
6MAP3K112.78876516
7TYRO32.60121977
8PRPF4B2.58705869
9MAP3K102.54389199
10CDK122.45841949
11MATK2.38151959
12DAPK12.16289802
13CDK72.05788677
14PDGFRA2.05296758
15FGFR42.03800740
16EEF2K1.96011001
17BMX1.92381887
18CDC71.86781169
19FGR1.82813209
20CSK1.81595901
21MST1R1.77415940
22IRAK31.77240041
23PIM21.75150909
24UHMK11.72572871
25NME21.70614658
26PINK11.70525162
27TRIB31.68777858
28DYRK1B1.59907226
29PRKD21.58682440
30PIM11.56691120
31NEK21.54160840
32CDK61.53963900
33PTK61.45400302
34RPS6KB21.34741486
35YES11.27846518
36MARK21.25581761
37MAP4K11.24104882
38WEE11.23723765
39PKN21.23595573
40MAP3K131.22189128
41NEK11.21487969
42ATR1.21181345
43MTOR1.19443590
44RPS6KC11.19432770
45RPS6KL11.19432770
46CHEK21.19109786
47PLK11.13892758
48PRKD31.13830739
49MAPK111.09429162
50BUB11.08369369
51RPS6KA61.06363286
52CDK41.06116696
53TRPM71.01691792
54DYRK30.99704133
55CDC42BPA0.96407755
56EPHA20.96021305
57TNK20.93358163
58MET0.91028451
59RPS6KA20.87542217
60MAP3K70.86714976
61FLT30.86076647
62STK100.86046488
63CHEK10.83788248
64LATS20.82888456
65ALK0.82075903
66TTK0.81693987
67EPHB10.80682315
68TESK10.79699244
69CDK20.77055274
70KSR20.77018060
71MAP2K20.75657057
72PAK40.75588707
73RPS6KA10.73717843
74GSK3A0.71676597
75MAP3K10.70952901
76NTRK10.70622531
77AURKB0.67949378
78MAPKAPK30.67283977
79SIK10.67011575
80RIPK40.65007702
81BRD40.63978883
82PDPK10.63827530
83RIPK10.63152814
84RET0.61529051
85TAOK20.61384342
86AKT30.60802621
87ATM0.60452824
88MAP3K80.60438917
89LRRK20.59266534
90CAMK1D0.58574775
91PASK0.58418043
92ERN10.57926525
93BTK0.57368380
94JAK30.57161640
95GRK60.55711442
96TBK10.54495879
97TYK20.54239674
98PAK20.52724889
99RAF10.52642772
100KDR0.52629752
101MAP3K140.52483236
102ZAP700.51835939
103SCYL20.50997246
104AURKA0.50969113
105HIPK20.50842744
106STK30.50401547
107RPS6KB10.49895965
108FGFR30.49351727
109NME10.49110088
110LMTK20.48654239
111PRKAA10.48569806
112MAP3K30.48324680
113TTN0.48275489
114CDK90.46799931
115IRAK20.46021144
116EGFR0.45908011
117TESK20.45767610
118STK40.45762893
119CDK10.44116358
120TSSK60.43454897
121MAPK10.41648067
122FGFR10.41523924
123MAPK120.38802434
124SIK20.38514007
125MAPK140.38072604
126CSNK2A20.38023778
127PDGFRB0.37887019
128CSNK2A10.37159263
129IRAK40.36595040
130TAOK10.36581157
131MAPK30.36183224
132AKT20.36055222
133CHUK0.35984972
134MAP2K30.34882525
135MAPK80.33188692
136MAP2K60.32330938
137BRAF0.31828285
138PTK20.31757516
139MAPK100.31384115
140ILK0.31130844
141LYN0.31112384
142BRSK20.30871131
143PRKG20.30828413
144SIK30.30624168
145MAPKAPK20.29770668
146BRSK10.29610534

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.62170043
2DNA replication_Homo sapiens_hsa030304.42115061
3Base excision repair_Homo sapiens_hsa034104.35553760
4Fatty acid biosynthesis_Homo sapiens_hsa000613.20238635
5Other glycan degradation_Homo sapiens_hsa005112.97430471
6Spliceosome_Homo sapiens_hsa030402.73809554
7RNA transport_Homo sapiens_hsa030132.54870286
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.50452384
9Nucleotide excision repair_Homo sapiens_hsa034202.29548096
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.16167594
11One carbon pool by folate_Homo sapiens_hsa006702.11796116
12Cell cycle_Homo sapiens_hsa041102.05846994
13Homologous recombination_Homo sapiens_hsa034402.00108772
14Notch signaling pathway_Homo sapiens_hsa043301.99303883
15* mRNA surveillance pathway_Homo sapiens_hsa030151.92237258
16mTOR signaling pathway_Homo sapiens_hsa041501.78893421
17Biosynthesis of amino acids_Homo sapiens_hsa012301.74933060
18Fanconi anemia pathway_Homo sapiens_hsa034601.68988116
192-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.66696998
20p53 signaling pathway_Homo sapiens_hsa041151.62234674
21Lysine degradation_Homo sapiens_hsa003101.53863061
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.49914495
23Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.44468554
24Hippo signaling pathway_Homo sapiens_hsa043901.43037311
25Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.33398513
26Adherens junction_Homo sapiens_hsa045201.30885758
27Sulfur relay system_Homo sapiens_hsa041221.30517613
28Hedgehog signaling pathway_Homo sapiens_hsa043401.30370513
29Neurotrophin signaling pathway_Homo sapiens_hsa047221.29225312
30Glioma_Homo sapiens_hsa052141.27361594
31Bladder cancer_Homo sapiens_hsa052191.23963356
32Basal cell carcinoma_Homo sapiens_hsa052171.17126284
33Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16564983
34AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.15933592
35Chronic myeloid leukemia_Homo sapiens_hsa052201.14648374
36Primary immunodeficiency_Homo sapiens_hsa053401.14088122
37Focal adhesion_Homo sapiens_hsa045101.08814431
38Renal cell carcinoma_Homo sapiens_hsa052111.08584158
39Choline metabolism in cancer_Homo sapiens_hsa052311.08545996
40Prostate cancer_Homo sapiens_hsa052151.07011717
41Inositol phosphate metabolism_Homo sapiens_hsa005621.05208677
42MicroRNAs in cancer_Homo sapiens_hsa052061.04078033
43Phospholipase D signaling pathway_Homo sapiens_hsa040721.04050409
44Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00835020
45Longevity regulating pathway - mammal_Homo sapiens_hsa042111.00552426
46Ribosome_Homo sapiens_hsa030100.99551805
47GnRH signaling pathway_Homo sapiens_hsa049120.99137477
48Colorectal cancer_Homo sapiens_hsa052100.98970763
49Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.98282657
50Fructose and mannose metabolism_Homo sapiens_hsa000510.97620981
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.96815439
52Viral carcinogenesis_Homo sapiens_hsa052030.96371747
53Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96066451
54Oocyte meiosis_Homo sapiens_hsa041140.95120207
55TGF-beta signaling pathway_Homo sapiens_hsa043500.94433692
56Shigellosis_Homo sapiens_hsa051310.94226489
57Estrogen signaling pathway_Homo sapiens_hsa049150.93558554
58Prion diseases_Homo sapiens_hsa050200.93409251
59Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.93218437
60Prolactin signaling pathway_Homo sapiens_hsa049170.92693361
61Arginine and proline metabolism_Homo sapiens_hsa003300.90206521
62Acute myeloid leukemia_Homo sapiens_hsa052210.89263225
63Selenocompound metabolism_Homo sapiens_hsa004500.88583342
64Central carbon metabolism in cancer_Homo sapiens_hsa052300.87556166
65Hepatitis C_Homo sapiens_hsa051600.86871242
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86644486
67Insulin resistance_Homo sapiens_hsa049310.85884084
68Small cell lung cancer_Homo sapiens_hsa052220.85840178
69Circadian rhythm_Homo sapiens_hsa047100.84834772
70RNA degradation_Homo sapiens_hsa030180.83052552
71VEGF signaling pathway_Homo sapiens_hsa043700.82431805
72Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.81255183
73HTLV-I infection_Homo sapiens_hsa051660.79891475
74Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77452783
75Viral myocarditis_Homo sapiens_hsa054160.76592721
76Herpes simplex infection_Homo sapiens_hsa051680.76079597
77ECM-receptor interaction_Homo sapiens_hsa045120.75519407
78Fatty acid metabolism_Homo sapiens_hsa012120.74956709
79Thyroid cancer_Homo sapiens_hsa052160.74929166
80T cell receptor signaling pathway_Homo sapiens_hsa046600.74723296
81Wnt signaling pathway_Homo sapiens_hsa043100.74346625
82Folate biosynthesis_Homo sapiens_hsa007900.73592815
83Epstein-Barr virus infection_Homo sapiens_hsa051690.73373245
84Pyrimidine metabolism_Homo sapiens_hsa002400.71398808
85Amoebiasis_Homo sapiens_hsa051460.70747172
86Non-homologous end-joining_Homo sapiens_hsa034500.69772250
87Legionellosis_Homo sapiens_hsa051340.68208119
88Melanogenesis_Homo sapiens_hsa049160.67827020
89Influenza A_Homo sapiens_hsa051640.67561953
90Adipocytokine signaling pathway_Homo sapiens_hsa049200.65411365
91Galactose metabolism_Homo sapiens_hsa000520.65372409
92Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.64694618
93Osteoclast differentiation_Homo sapiens_hsa043800.64308180
94Endocytosis_Homo sapiens_hsa041440.63418796
95Glycerophospholipid metabolism_Homo sapiens_hsa005640.62355955
96Toxoplasmosis_Homo sapiens_hsa051450.62330413
97Cyanoamino acid metabolism_Homo sapiens_hsa004600.61311602
98AMPK signaling pathway_Homo sapiens_hsa041520.59622817
99Glucagon signaling pathway_Homo sapiens_hsa049220.59598669
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.59487673
101Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.59295213
102B cell receptor signaling pathway_Homo sapiens_hsa046620.58607248
103Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.57144047
104Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.56808063
105Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.56790469
106Arginine biosynthesis_Homo sapiens_hsa002200.56779659
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.56380163
108Hepatitis B_Homo sapiens_hsa051610.54529876
109Insulin signaling pathway_Homo sapiens_hsa049100.54470653
110Platelet activation_Homo sapiens_hsa046110.54195479
111Endometrial cancer_Homo sapiens_hsa052130.54011814
112Proteoglycans in cancer_Homo sapiens_hsa052050.53294651
113TNF signaling pathway_Homo sapiens_hsa046680.53279140
114Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52344166
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.50169877
116Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.49266202
117Non-small cell lung cancer_Homo sapiens_hsa052230.47926520
118Rap1 signaling pathway_Homo sapiens_hsa040150.47847085
119Carbon metabolism_Homo sapiens_hsa012000.47188577
120Pentose phosphate pathway_Homo sapiens_hsa000300.46804712
121RNA polymerase_Homo sapiens_hsa030200.46163882
122HIF-1 signaling pathway_Homo sapiens_hsa040660.45864934
123Thyroid hormone signaling pathway_Homo sapiens_hsa049190.44618944
124Axon guidance_Homo sapiens_hsa043600.44512446
125Long-term potentiation_Homo sapiens_hsa047200.43848291
126Antigen processing and presentation_Homo sapiens_hsa046120.42631907
127Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.42166085
128Regulation of actin cytoskeleton_Homo sapiens_hsa048100.42156054
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.41140711
130Pancreatic cancer_Homo sapiens_hsa052120.40628829
131Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.40240168
132Measles_Homo sapiens_hsa051620.38430762
133Tight junction_Homo sapiens_hsa045300.36365061
134Basal transcription factors_Homo sapiens_hsa030220.35436386
135Dorso-ventral axis formation_Homo sapiens_hsa043200.35254998
136Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34602120
137Pathways in cancer_Homo sapiens_hsa052000.33948177
138Apoptosis_Homo sapiens_hsa042100.33743232
139Drug metabolism - other enzymes_Homo sapiens_hsa009830.33061012
140N-Glycan biosynthesis_Homo sapiens_hsa005100.33004685
141Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31823163
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.30957185
143ErbB signaling pathway_Homo sapiens_hsa040120.29332979

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