ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	positive regulation of cell size (GO:0045793)	5.98849516
2	positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)	5.86009057
3	diaphragm development (GO:0060539)	5.23090621
4	skeletal muscle organ development (GO:0060538)	5.06896744
5	regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)	4.70886608
6	negative regulation of vascular permeability (GO:0043116)	4.59559615
7	arginine catabolic process (GO:0006527)	4.41392001
8	negative regulation of peptidyl-threonine phosphorylation (GO:0010801)	4.36851313
9	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	4.36491388
10	negative regulation of neurotransmitter transport (GO:0051589)	4.24318104
11	apical protein localization (GO:0045176)	4.13502892
12	cellular protein complex localization (GO:0034629)	4.02948928
13	response to lipoprotein particle (GO:0055094)	3.92966740
14	arginine metabolic process (GO:0006525)	3.83930822
15	branching involved in prostate gland morphogenesis (GO:0060442)	3.76357626
16	histone H3-K4 methylation (GO:0051568)	3.74919669
17	protein complex localization (GO:0031503)	3.69919766
18	chromatin silencing (GO:0006342)	3.67973610
19	pyrimidine nucleoside salvage (GO:0043097)	3.62830770
20	pyrimidine-containing compound salvage (GO:0008655)	3.62830770
21	cell migration involved in gastrulation (GO:0042074)	3.54005012
22	axonal fasciculation (GO:0007413)	3.45083629
23	regulation of intracellular estrogen receptor signaling pathway (GO:0033146)	3.43153433
24	regulation of stem cell maintenance (GO:2000036)	3.39701639
25	pyrimidine ribonucleoside monophosphate metabolic process (GO:0009173)	3.36233181
26	UMP biosynthetic process (GO:0006222)	3.36233181
27	pyrimidine ribonucleoside monophosphate biosynthetic process (GO:0009174)	3.36233181
28	UMP metabolic process (GO:0046049)	3.36233181
29	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.36036848
30	regulation of NFAT protein import into nucleus (GO:0051532)	3.27371727
31	cytoskeletal anchoring at plasma membrane (GO:0007016)	3.26923551
32	myoblast fusion (GO:0007520)	3.19698807
33	acrosome reaction (GO:0007340)	3.19569059
34	regulation of synaptic vesicle exocytosis (GO:2000300)	3.15699524
35	regulation of neurotransmitter uptake (GO:0051580)	3.08689155
36	regulation of mRNA catabolic process (GO:0061013)	3.05033269
37	positive regulation of catecholamine secretion (GO:0033605)	3.02321833
38	negative regulation of potassium ion transport (GO:0043267)	3.01120262
39	regulation of cilium assembly (GO:1902017)	3.00428729
40	RNA stabilization (GO:0043489)	3.00125358
41	mRNA stabilization (GO:0048255)	3.00125358
42	regulation of cholesterol biosynthetic process (GO:0045540)	2.98474901
43	regulation of synaptic vesicle transport (GO:1902803)	2.97364665
44	positive regulation of DNA-dependent DNA replication (GO:2000105)	2.96070737
45	protein targeting to Golgi (GO:0000042)	2.94639821
46	asymmetric protein localization (GO:0008105)	2.93707821
47	positive regulation of guanylate cyclase activity (GO:0031284)	2.88122977
48	sperm motility (GO:0030317)	2.84436708
49	syncytium formation by plasma membrane fusion (GO:0000768)	2.80786369
50	3-UTR-mediated mRNA stabilization (GO:0070935)	2.79905259
51	negative regulation of gene expression, epigenetic (GO:0045814)	2.79495866
52	fusion of sperm to egg plasma membrane (GO:0007342)	2.77523098
53	positive regulation of mRNA catabolic process (GO:0061014)	2.76001835
54	establishment of protein localization to Golgi (GO:0072600)	2.75332091
55	positive regulation of receptor biosynthetic process (GO:0010870)	2.74991141
56	DNA packaging (GO:0006323)	2.74637478
57	retrograde transport, vesicle recycling within Golgi (GO:0000301)	2.74025560
58	chromosome condensation (GO:0030261)	2.73980525
59	camera-type eye morphogenesis (GO:0048593)	2.70933137
60	artery development (GO:0060840)	2.62001900
61	regulation of protein deacetylation (GO:0090311)	2.60779688
62	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.60738686
63	negative regulation of cell size (GO:0045792)	2.58764413
64	exogenous drug catabolic process (GO:0042738)	2.57960928
65	positive regulation of Rab GTPase activity (GO:0032851)	2.56890651
66	regulation of Rab GTPase activity (GO:0032313)	2.56890651
67	gastrulation with mouth forming second (GO:0001702)	2.56787301
68	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.56028560
69	pyrimidine nucleobase catabolic process (GO:0006208)	2.55969241
70	positive regulation of cell cycle checkpoint (GO:1901978)	2.55146347
71	regulation of mitochondrial translation (GO:0070129)	2.54942601
72	CTP metabolic process (GO:0046036)	2.54461810
73	CTP biosynthetic process (GO:0006241)	2.54461810
74	microtubule depolymerization (GO:0007019)	2.53967616
75	embryonic retina morphogenesis in camera-type eye (GO:0060059)	2.53636098
76	protein-DNA complex disassembly (GO:0032986)	2.52741034
77	nucleosome disassembly (GO:0006337)	2.52741034
78	pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)	2.52121608
79	regulation of guanylate cyclase activity (GO:0031282)	2.51194956
80	establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)	2.50711334
81	synaptic vesicle exocytosis (GO:0016079)	2.49964976
82	regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)	2.48354252
83	neurofilament cytoskeleton organization (GO:0060052)	2.48134606
84	biotin metabolic process (GO:0006768)	2.47149416
85	negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)	2.47085962
86	DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla	2.46384140
87	neuron recognition (GO:0008038)	2.45898233
88	regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)	2.45763899
89	positive regulation of signal transduction by p53 class mediator (GO:1901798)	2.45340141
90	neuron cell-cell adhesion (GO:0007158)	2.44816479
91	positive regulation of transcription from RNA polymerase III promoter (GO:0045945)	2.44615095
92	pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)	2.44585498
93	neurotransmitter biosynthetic process (GO:0042136)	2.44287367
94	negative regulation of retinoic acid receptor signaling pathway (GO:0048387)	2.44152136
95	peptidyl-cysteine modification (GO:0018198)	2.42569115
96	regulation of cell size (GO:0008361)	2.41584026
97	insulin-like growth factor receptor signaling pathway (GO:0048009)	2.41550825
98	regulation of cilium movement (GO:0003352)	2.40657522
99	DNA damage response, signal transduction resulting in transcription (GO:0042772)	2.38302127
100	protein localization to synapse (GO:0035418)	2.37795261

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	8.04663113
2	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	4.35906697
3	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	3.12660201
4	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	2.83039989
5	MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human	2.81695317
6	E2F7_22180533_ChIP-Seq_HELA_Human	2.58754894
7	ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse	2.34535438
8	MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse	2.33190700
9	DROSHA_22980978_ChIP-Seq_HELA_Human	2.32191749
10	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	2.29621264
11	PIAS1_25552417_ChIP-Seq_VCAP_Human	2.22287004
12	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.95344461
13	ZNF274_21170338_ChIP-Seq_K562_Hela	1.93801112
14	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.90033252
15	AR_21572438_ChIP-Seq_LNCaP_Human	1.84692108
16	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.79833404
17	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.77140235
18	KDM2B_26808549_Chip-Seq_K562_Human	1.75575351
19	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.75171363
20	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.74134601
21	AR_21909140_ChIP-Seq_LNCAP_Human	1.67390795
22	SMC4_20622854_ChIP-Seq_HELA_Human	1.66826282
23	GATA1_22025678_ChIP-Seq_K562_Human	1.65423344
24	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.65376165
25	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.65364421
26	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.58088819
27	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	1.56387367
28	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.53360774
29	NANOG_21062744_ChIP-ChIP_HESCs_Human	1.51758546
30	TCF3_18467660_ChIP-ChIP_MESCs_Mouse	1.50864626
31	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.49658600
32	IGF1R_20145208_ChIP-Seq_DFB_Human	1.43829455
33	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.43689582
34	RNF2_18974828_ChIP-Seq_MESCs_Mouse	1.42245709
35	EZH2_18974828_ChIP-Seq_MESCs_Mouse	1.42245709
36	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.39284270
37	REST_21632747_ChIP-Seq_MESCs_Mouse	1.37365852
38	TFAP2C_20629094_ChIP-Seq_MCF-7_Human	1.36393781
39	FUS_26573619_Chip-Seq_HEK293_Human	1.32582846
40	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.28123055
41	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.27672153
42	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	1.27019133
43	RNF2_27304074_Chip-Seq_NSC_Mouse	1.25849852
44	SMAD4_21741376_ChIP-Seq_HESCs_Human	1.25143749
45	GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	1.23912064
46	ZFP281_27345836_Chip-Seq_ESCs_Mouse	1.22905297
47	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.21568628
48	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.21441949
49	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.19957027
50	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.19380423
51	CHD1_26751641_Chip-Seq_LNCaP_Human	1.19370477
52	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.19051696
53	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.18978284
54	ARNT_22903824_ChIP-Seq_MCF-7_Human	1.18487320
55	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.18401536
56	CREM_20920259_ChIP-Seq_GC1-SPG_Mouse	1.18340872
57	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.17858083
58	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.16218438
59	ISL1_27105846_Chip-Seq_CPCs_Mouse	1.15882153
60	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.15573909
61	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.15062444
62	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.13963758
63	FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human	1.13177543
64	RCOR2_21632747_ChIP-Seq_MESCs_Mouse	1.11229758
65	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.09996111
66	AR_19668381_ChIP-Seq_PC3_Human	1.08225520
67	SMAD4_21741376_ChIP-Seq_ESCs_Human	1.07602669
68	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.06550542
69	SMAD3_22036565_ChIP-Seq_ESCs_Mouse	1.05735410
70	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.05450746
71	E2F1_17053090_ChIP-ChIP_MCF-7_Human	1.05128347
72	LXR_22292898_ChIP-Seq_THP-1_Human	1.04353301
73	RARB_27405468_Chip-Seq_BRAIN_Mouse	1.03846888
74	OCT1_27270436_Chip-Seq_PROSTATE_Human	1.02757998
75	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.00694842
76	AR_21915096_ChIP-Seq_LNCaP-1F5_Human	1.00411418
77	P53_22127205_ChIP-Seq_FIBROBLAST_Human	1.00293840
78	FOXA1_25552417_ChIP-Seq_VCAP_Human	0.99784736
79	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.99450382
80	SMAD4_21741376_ChIP-Seq_EPCs_Human	0.99120538
81	CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat	0.97841427
82	CTNNB1_20460455_ChIP-Seq_HCT116_Human	0.97605489
83	AHR_22903824_ChIP-Seq_MCF-7_Human	0.97392919
84	AR_25329375_ChIP-Seq_VCAP_Human	0.97358709
85	YAP1_20516196_ChIP-Seq_MESCs_Mouse	0.96672310
86	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	0.95773212
87	SOX3_22085726_ChIP-Seq_NPCs_Mouse	0.95505232
88	RCOR3_21632747_ChIP-Seq_MESCs_Mouse	0.94488470
89	SOX2_18358816_ChIP-ChIP_MESCs_Mouse	0.93231257
90	ERG_21242973_ChIP-ChIP_JURKAT_Human	0.92590366
91	ZFP281_18757296_ChIP-ChIP_E14_Mouse	0.91958631
92	KDM5A_27292631_Chip-Seq_BREAST_Human	0.91004904
93	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.90836340
94	CREB1_26743006_Chip-Seq_LNCaP_Human	0.90606279
95	TAF15_26573619_Chip-Seq_HEK293_Human	0.89092985
96	DMRT1_23473982_ChIP-Seq_TESTES_Mouse	0.88066357
97	ZNF217_24962896_ChIP-Seq_MCF-7_Human	0.85968847
98	GATA1_26923725_Chip-Seq_HPCs_Mouse	0.85602828
99	TET1_21490601_ChIP-Seq_MESCs_Mouse	0.85563510
100	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.85473444

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0002234_abnormal_pharynx_morphology	4.80269992
2	MP0003646_muscle_fatigue	4.22734266
3	MP0000566_synostosis	4.18848970
4	MP0004858_abnormal_nervous_system	4.17822706
5	MP0005645_abnormal_hypothalamus_physiol	3.70512325
6	MP0004233_abnormal_muscle_weight	3.62604856
7	MP0003283_abnormal_digestive_organ	3.57643420
8	MP0002822_catalepsy	3.38120224
9	MP0000537_abnormal_urethra_morphology	2.75638799
10	MP0005167_abnormal_blood-brain_barrier	2.69937693
11	MP0002009_preneoplasia	2.43521785
12	MP0004043_abnormal_pH_regulation	2.25397196
13	MP0009053_abnormal_anal_canal	2.00421958
14	MP0004859_abnormal_synaptic_plasticity	1.90925975
15	MP0004270_analgesia	1.84332261
16	MP0003315_abnormal_perineum_morphology	1.78416099
17	MP0005076_abnormal_cell_differentiation	1.78185913
18	MP0005360_urolithiasis	1.62418263
19	MP0005187_abnormal_penis_morphology	1.61451207
20	MP0000955_abnormal_spinal_cord	1.60833535
21	MP0005394_taste/olfaction_phenotype	1.52614347
22	MP0005499_abnormal_olfactory_system	1.52614347
23	MP0003718_maternal_effect	1.52084771
24	MP0003890_abnormal_embryonic-extraembry	1.41380390
25	MP0001984_abnormal_olfaction	1.39074174
26	MP0000778_abnormal_nervous_system	1.34875932
27	MP0002233_abnormal_nose_morphology	1.33776257
28	MP0003119_abnormal_digestive_system	1.32620959
29	MP0003635_abnormal_synaptic_transmissio	1.31941370
30	MP0003937_abnormal_limbs/digits/tail_de	1.30127645
31	MP0005410_abnormal_fertilization	1.28931263
32	MP0004742_abnormal_vestibular_system	1.27465853
33	MP0004811_abnormal_neuron_physiology	1.22831666
34	MP0010368_abnormal_lymphatic_system	1.21949462
35	MP0002184_abnormal_innervation	1.21063940
36	MP0002063_abnormal_learning/memory/cond	1.20579202
37	MP0001664_abnormal_digestion	1.19072915
38	MP0005670_abnormal_white_adipose	1.16340955
39	MP0002735_abnormal_chemical_nociception	1.14507763
40	MP0003861_abnormal_nervous_system	1.12255289
41	MP0004084_abnormal_cardiac_muscle	1.11750999
42	MP0000733_abnormal_muscle_development	1.10665524
43	MP0000631_abnormal_neuroendocrine_gland	1.09628696
44	MP0002734_abnormal_mechanical_nocicepti	1.01936239
45	MP0000538_abnormal_urinary_bladder	1.01706060
46	MP0003698_abnormal_male_reproductive	1.01540052
47	MP0009745_abnormal_behavioral_response	1.01310559
48	MP0010307_abnormal_tumor_latency	0.99847653
49	MP0001529_abnormal_vocalization	0.99436383
50	MP0002064_seizures	0.98672174
51	MP0002572_abnormal_emotion/affect_behav	0.98587216
52	MP0005423_abnormal_somatic_nervous	0.97141612
53	MP0002084_abnormal_developmental_patter	0.96907211
54	MP0004133_heterotaxia	0.96016803
55	MP0000467_abnormal_esophagus_morphology	0.95959306
56	MP0002557_abnormal_social/conspecific_i	0.95220378
57	MP0001348_abnormal_lacrimal_gland	0.93875014
58	MP0003631_nervous_system_phenotype	0.92481704
59	MP0002152_abnormal_brain_morphology	0.92279071
60	MP0002736_abnormal_nociception_after	0.87909259
61	MP0001919_abnormal_reproductive_system	0.86161287
62	MP0003633_abnormal_nervous_system	0.85942263
63	MP0001485_abnormal_pinna_reflex	0.85803166
64	MP0003880_abnormal_central_pattern	0.85268341
65	MP0001501_abnormal_sleep_pattern	0.85062467
66	MP0008961_abnormal_basal_metabolism	0.84884572
67	MP0002249_abnormal_larynx_morphology	0.84400160
68	MP0000534_abnormal_ureter_morphology	0.83638911
69	MP0003045_fibrosis	0.82963533
70	MP0002116_abnormal_craniofacial_bone	0.82235804
71	MP0002272_abnormal_nervous_system	0.80375681
72	MP0005623_abnormal_meninges_morphology	0.79841573
73	MP0005380_embryogenesis_phenotype	0.78730666
74	MP0001672_abnormal_embryogenesis/_devel	0.78730666
75	MP0003942_abnormal_urinary_system	0.78522622
76	MP0002067_abnormal_sensory_capabilities	0.78374020
77	MP0002882_abnormal_neuron_morphology	0.78047447
78	MP0001440_abnormal_grooming_behavior	0.76984307
79	MP0003879_abnormal_hair_cell	0.76759306
80	MP0003122_maternal_imprinting	0.76057041
81	MP0000432_abnormal_head_morphology	0.75293211
82	MP0001486_abnormal_startle_reflex	0.75166671
83	MP0002109_abnormal_limb_morphology	0.74371258
84	MP0003935_abnormal_craniofacial_develop	0.74110058
85	MP0009672_abnormal_birth_weight	0.73725709
86	MP0001929_abnormal_gametogenesis	0.73638403
87	MP0001968_abnormal_touch/_nociception	0.72593418
88	MP0002161_abnormal_fertility/fecundity	0.72105368
89	MP0008872_abnormal_physiological_respon	0.71982477
90	MP0004036_abnormal_muscle_relaxation	0.71201445
91	MP0010234_abnormal_vibrissa_follicle	0.69206226
92	MP0002085_abnormal_embryonic_tissue	0.67654434
93	MP0003632_abnormal_nervous_system	0.67201373
94	MP0003878_abnormal_ear_physiology	0.66999964
95	MP0005377_hearing/vestibular/ear_phenot	0.66999964
96	MP0009046_muscle_twitch	0.66695141
97	MP0003123_paternal_imprinting	0.66028477
98	MP0001970_abnormal_pain_threshold	0.66020342
99	MP0002069_abnormal_eating/drinking_beha	0.65868580
100	MP0003984_embryonic_growth_retardation	0.65856327

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Sparse lateral eyebrow (HP:0005338)	6.17277390
2	Anal stenosis (HP:0002025)	6.02753100
3	Intestinal fistula (HP:0100819)	4.94481849
4	Abnormality of the fingertips (HP:0001211)	4.85261599
5	Lip pit (HP:0100267)	4.79332216
6	Autoimmune thrombocytopenia (HP:0001973)	4.27932456
7	Short 5th finger (HP:0009237)	4.15420440
8	Depressed nasal tip (HP:0000437)	4.02596527
9	Aplasia/Hypoplasia of the 5th finger (HP:0006262)	3.87922811
10	Ureteral stenosis (HP:0000071)	3.66099745
11	Ureteral obstruction (HP:0006000)	3.40168918
12	Long palpebral fissure (HP:0000637)	3.02794381
13	Myokymia (HP:0002411)	2.92567697
14	Absent eyebrow (HP:0002223)	2.90681635
15	Periauricular skin pits (HP:0100277)	2.88018410
16	Preauricular pit (HP:0004467)	2.88018410
17	Lower limb hyperreflexia (HP:0002395)	2.87436843
18	Ectopic kidney (HP:0000086)	2.84430204
19	Resting tremor (HP:0002322)	2.74736201
20	Aplasia/Hypoplasia of the vertebrae (HP:0008515)	2.62712320
21	Vertebral hypoplasia (HP:0008417)	2.62712320
22	Abnormality of the distal phalanges of the toes (HP:0010182)	2.62046579
23	Dysmetric saccades (HP:0000641)	2.61878437
24	Cerebellar dysplasia (HP:0007033)	2.58270026
25	High anterior hairline (HP:0009890)	2.52326257
26	Self-mutilation (HP:0000742)	2.44595467
27	Facial cleft (HP:0002006)	2.40356013
28	Aplasia involving bones of the extremities (HP:0009825)	2.38278201
29	Aplasia involving bones of the upper limbs (HP:0009823)	2.38278201
30	Aplasia of the phalanges of the hand (HP:0009802)	2.38278201
31	Precocious puberty (HP:0000826)	2.29869049
32	Pheochromocytoma (HP:0002666)	2.27347750
33	Abnormal tarsal ossification (HP:0008369)	2.21717314
34	Popliteal pterygium (HP:0009756)	2.18265863
35	Preaxial foot polydactyly (HP:0001841)	2.13897970
36	Broad thumb (HP:0011304)	2.11243319
37	Neonatal death (HP:0003811)	2.10398631
38	Atonic seizures (HP:0010819)	2.10086599
39	Short 1st metacarpal (HP:0010034)	2.09185703
40	Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)	2.09185703
41	Morphological abnormality of the inner ear (HP:0011390)	2.07879593
42	Skin pits (HP:0100276)	2.05049174
43	Mask-like facies (HP:0000298)	2.01042727
44	Termporal pattern (HP:0011008)	2.00596267
45	Insidious onset (HP:0003587)	2.00596267
46	Abnormality of the aortic arch (HP:0012303)	1.99953382
47	Cortical dysplasia (HP:0002539)	1.99878166
48	Fibular aplasia (HP:0002990)	1.99772464
49	Coarctation of aorta (HP:0001680)	1.98275223
50	Anal atresia (HP:0002023)	1.97539069
51	Abnormality of the 1st metacarpal (HP:0010009)	1.94670428
52	Non-midline cleft lip (HP:0100335)	1.92127928
53	Abnormality of abdominal situs (HP:0011620)	1.90118849
54	Abdominal situs inversus (HP:0003363)	1.90118849
55	Septate vagina (HP:0001153)	1.89996818
56	Morphological abnormality of the middle ear (HP:0008609)	1.89017523
57	Abnormality of the phalanges of the hallux (HP:0010057)	1.87372816
58	Pachygyria (HP:0001302)	1.84803674
59	Leiomyosarcoma (HP:0100243)	1.84609925
60	Uterine leiomyosarcoma (HP:0002891)	1.84609925
61	Short palm (HP:0004279)	1.84316803
62	Obstructive sleep apnea (HP:0002870)	1.77984366
63	Progressive sensorineural hearing impairment (HP:0000408)	1.77432361
64	Absent eyelashes (HP:0000561)	1.76004342
65	Narrow palate (HP:0000189)	1.75621758
66	Abnormality of the distal phalanx of the thumb (HP:0009617)	1.74032923
67	Fatigue (HP:0012378)	1.73471965
68	Turricephaly (HP:0000262)	1.71217009
69	Transitional cell carcinoma of the bladder (HP:0006740)	1.71139858
70	Urinary urgency (HP:0000012)	1.70996717
71	Neoplasm of the heart (HP:0100544)	1.68970852
72	Short phalanx of the thumb (HP:0009660)	1.67790697
73	Generalized aminoaciduria (HP:0002909)	1.66975705
74	Shawl scrotum (HP:0000049)	1.66207000
75	Bifid scrotum (HP:0000048)	1.64044958
76	Amblyopia (HP:0000646)	1.63638497
77	Broad face (HP:0000283)	1.62936259
78	Flat acetabular roof (HP:0003180)	1.62167924
79	Broad phalanges of the hand (HP:0009768)	1.59886902
80	Abnormality of the parathyroid morphology (HP:0011766)	1.59730635
81	Poor head control (HP:0002421)	1.59616120
82	Abnormality of the periventricular white matter (HP:0002518)	1.59591968
83	Type II lissencephaly (HP:0007260)	1.59314208
84	Aplasia/Hypoplasia of the brainstem (HP:0007362)	1.58901731
85	Hypoplasia of the brainstem (HP:0002365)	1.58901731
86	Asymmetry of the thorax (HP:0001555)	1.58598726
87	Neuroendocrine neoplasm (HP:0100634)	1.58335174
88	Abnormal ventriculo-arterial connection (HP:0011563)	1.55639679
89	Transposition of the great arteries (HP:0001669)	1.55639679
90	Abnormal connection of the cardiac segments (HP:0011545)	1.55639679
91	Wide intermamillary distance (HP:0006610)	1.55497110
92	Generalized hypotonia (HP:0001290)	1.55259433
93	Renal cell carcinoma (HP:0005584)	1.54950569
94	Fetal akinesia sequence (HP:0001989)	1.54358759
95	Impaired smooth pursuit (HP:0007772)	1.53327292
96	Bladder neoplasm (HP:0009725)	1.52595094
97	Bladder carcinoma (HP:0002862)	1.52595094
98	Frequent falls (HP:0002359)	1.52516254
99	Hyperacusis (HP:0010780)	1.51837877
100	Partial agenesis of the corpus callosum (HP:0001338)	1.50335379

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	EEF2K	4.70066401
2	CAMK1D	4.67136926
3	CAMK1G	4.49023452
4	STK24	4.31864470
5	WNK4	3.66323416
6	STK39	3.38848365
7	MAP3K4	2.93268652
8	MAP2K7	2.68003291
9	CCNB1	2.59345920
10	MAP3K2	2.19523145
11	PINK1	2.16894883
12	PRKD3	2.14934908
13	PKN2	2.04385486
14	TAOK1	2.00642628
15	MAP3K3	1.97890932
16	CASK	1.82846155
17	WNK1	1.74114257
18	ZAK	1.69787535
19	BRD4	1.65550036
20	PNCK	1.61575404
21	MARK1	1.57153320
22	INSRR	1.48682607
23	NTRK2	1.48164553
24	CAMK1	1.39355778
25	AKT3	1.36452990
26	PLK4	1.34086229
27	CDK12	1.33522434
28	CAMK4	1.31785294
29	BMPR1B	1.29559661
30	ILK	1.28714529
31	MAP2K4	1.23775137
32	TRIB3	1.21649236
33	MINK1	1.20586593
34	CHEK2	1.17695889
35	EPHA4	1.07189644
36	SRPK1	1.01678363
37	CSNK1A1L	0.98700542
38	TNK2	0.95204840
39	ICK	0.92787166
40	CSNK1G2	0.85213331
41	CSNK1G3	0.84558309
42	RPS6KL1	0.79841150
43	RPS6KC1	0.79841150
44	MTOR	0.79505027
45	SGK494	0.79311778
46	SGK223	0.79311778
47	IRAK2	0.79164354
48	IRAK3	0.76324216
49	CDK9	0.76208012
50	RPS6KA6	0.75233786
51	ERBB4	0.71792969
52	RPS6KA2	0.70998289
53	CSNK1G1	0.68167936
54	MAPKAPK3	0.65870916
55	NTRK3	0.65088215
56	CDC7	0.64630722
57	RET	0.59833175
58	ACVR1B	0.57573690
59	MAPK13	0.56502943
60	ERBB3	0.55402387
61	BCR	0.54689724
62	MARK2	0.54689059
63	TYRO3	0.52726724
64	FER	0.52148950
65	JAK3	0.51071964
66	DAPK2	0.50944045
67	PRKCZ	0.50447672
68	PRKD2	0.50434410
69	PRKAA1	0.49941607
70	CDK7	0.48373205
71	MAP3K10	0.48032454
72	SGK2	0.46880418
73	MAP3K9	0.45116247
74	LATS2	0.44135822
75	TNIK	0.43294719
76	CAMKK1	0.42039910
77	TGFBR1	0.39447707
78	EPHA3	0.37150620
79	SIK2	0.33946276
80	TTK	0.33914269
81	FLT3	0.30726889
82	CDK2	0.30537334
83	AKT2	0.30396124
84	PBK	0.30018853
85	RPS6KB1	0.27012998
86	PRKCQ	0.26824542
87	SMG1	0.26007356
88	PRKCI	0.25830564
89	CDK1	0.25607316
90	MAPKAPK5	0.25236148
91	PDPK1	0.25179081
92	PDK1	0.24147742
93	CDK5	0.23993391
94	PLK2	0.22872833
95	AURKA	0.22171478
96	SGK3	0.21582616
97	RPS6KA5	0.21514882
98	MAPK10	0.20858228
99	GSK3B	0.20614513
100	DYRK3	0.19201652

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Fatty acid biosynthesis_Homo sapiens_hsa00061	4.70551303
2	Arginine biosynthesis_Homo sapiens_hsa00220	3.40945683
3	Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961	2.21998845
4	Lysine degradation_Homo sapiens_hsa00310	2.17161720
5	AMPK signaling pathway_Homo sapiens_hsa04152	1.95763789
6	Nicotine addiction_Homo sapiens_hsa05033	1.92757789
7	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	1.82067256
8	Dopaminergic synapse_Homo sapiens_hsa04728	1.78001325
9	Circadian entrainment_Homo sapiens_hsa04713	1.76933356
10	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.61948163
11	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	1.51637510
12	Alcoholism_Homo sapiens_hsa05034	1.49834627
13	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.49427172
14	mRNA surveillance pathway_Homo sapiens_hsa03015	1.48031481
15	Type II diabetes mellitus_Homo sapiens_hsa04930	1.47088658
16	Fatty acid metabolism_Homo sapiens_hsa01212	1.37711381
17	Longevity regulating pathway - mammal_Homo sapiens_hsa04211	1.34922537
18	Insulin signaling pathway_Homo sapiens_hsa04910	1.33401747
19	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	1.29639136
20	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.24769404
21	N-Glycan biosynthesis_Homo sapiens_hsa00510	1.24647379
22	Salivary secretion_Homo sapiens_hsa04970	1.24219586
23	Arginine and proline metabolism_Homo sapiens_hsa00330	1.22176578
24	Long-term potentiation_Homo sapiens_hsa04720	1.21812777
25	Taste transduction_Homo sapiens_hsa04742	1.21033774
26	Hippo signaling pathway_Homo sapiens_hsa04390	1.19984733
27	Olfactory transduction_Homo sapiens_hsa04740	1.19543129
28	Cocaine addiction_Homo sapiens_hsa05030	1.17839485
29	Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141	1.16557083
30	Adherens junction_Homo sapiens_hsa04520	1.12764366
31	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	1.09262706
32	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.06767521
33	Vitamin B6 metabolism_Homo sapiens_hsa00750	1.06420825
34	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.04359281
35	GABAergic synapse_Homo sapiens_hsa04727	1.02444331
36	Glutamatergic synapse_Homo sapiens_hsa04724	1.00491772
37	mTOR signaling pathway_Homo sapiens_hsa04150	0.99150785
38	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.99078618
39	Cholinergic synapse_Homo sapiens_hsa04725	0.99006917
40	Amphetamine addiction_Homo sapiens_hsa05031	0.98435824
41	ErbB signaling pathway_Homo sapiens_hsa04012	0.97775033
42	Long-term depression_Homo sapiens_hsa04730	0.97566909
43	Thyroid hormone signaling pathway_Homo sapiens_hsa04919	0.97390976
44	Axon guidance_Homo sapiens_hsa04360	0.97150141
45	Melanogenesis_Homo sapiens_hsa04916	0.97022661
46	Phosphatidylinositol signaling system_Homo sapiens_hsa04070	0.96875156
47	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.95488801
48	Estrogen signaling pathway_Homo sapiens_hsa04915	0.94120859
49	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.93098623
50	Insulin secretion_Homo sapiens_hsa04911	0.90742513
51	Prostate cancer_Homo sapiens_hsa05215	0.87418086
52	Morphine addiction_Homo sapiens_hsa05032	0.86924694
53	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.83902659
54	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.81429563
55	Oocyte meiosis_Homo sapiens_hsa04114	0.79978532
56	Pyrimidine metabolism_Homo sapiens_hsa00240	0.79030137
57	Glucagon signaling pathway_Homo sapiens_hsa04922	0.78638434
58	Inositol phosphate metabolism_Homo sapiens_hsa00562	0.77208842
59	RNA transport_Homo sapiens_hsa03013	0.76969269
60	Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914	0.76521381
61	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	0.76090360
62	Wnt signaling pathway_Homo sapiens_hsa04310	0.75683701
63	Glioma_Homo sapiens_hsa05214	0.75671539
64	Vibrio cholerae infection_Homo sapiens_hsa05110	0.73981127
65	Neurotrophin signaling pathway_Homo sapiens_hsa04722	0.73728784
66	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.71754395
67	Steroid biosynthesis_Homo sapiens_hsa00100	0.71633925
68	Gastric acid secretion_Homo sapiens_hsa04971	0.71107640
69	Gap junction_Homo sapiens_hsa04540	0.70661397
70	cAMP signaling pathway_Homo sapiens_hsa04024	0.70637215
71	Sphingolipid signaling pathway_Homo sapiens_hsa04071	0.69581996
72	Colorectal cancer_Homo sapiens_hsa05210	0.66626288
73	Basal cell carcinoma_Homo sapiens_hsa05217	0.66229870
74	Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923	0.65074920
75	Choline metabolism in cancer_Homo sapiens_hsa05231	0.64713379
76	Endometrial cancer_Homo sapiens_hsa05213	0.61517439
77	Renin-angiotensin system_Homo sapiens_hsa04614	0.61342174
78	Renin secretion_Homo sapiens_hsa04924	0.61199591
79	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.60376834
80	Tight junction_Homo sapiens_hsa04530	0.59951177
81	Other types of O-glycan biosynthesis_Homo sapiens_hsa00514	0.59373826
82	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.58292054
83	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.57716206
84	Central carbon metabolism in cancer_Homo sapiens_hsa05230	0.56353847
85	Calcium signaling pathway_Homo sapiens_hsa04020	0.56298148
86	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.55699110
87	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.55687326
88	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.54808960
89	GnRH signaling pathway_Homo sapiens_hsa04912	0.53851224
90	Pyruvate metabolism_Homo sapiens_hsa00620	0.53356200
91	Rap1 signaling pathway_Homo sapiens_hsa04015	0.52307183
92	Bile secretion_Homo sapiens_hsa04976	0.51181565
93	ABC transporters_Homo sapiens_hsa02010	0.49704833
94	Renal cell carcinoma_Homo sapiens_hsa05211	0.49544433
95	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.49223821
96	One carbon pool by folate_Homo sapiens_hsa00670	0.45210296
97	Nucleotide excision repair_Homo sapiens_hsa03420	0.42367638
98	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.41961858
99	Basal transcription factors_Homo sapiens_hsa03022	0.41607439
100	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	0.40556981

CPSF1P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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