CPSF4L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)9.03877608
2base-excision repair, AP site formation (GO:0006285)7.55685557
3pyrimidine deoxyribonucleotide catabolic process (GO:0009223)7.08805410
4regulation of female gonad development (GO:2000194)7.07659944
5pyrimidine nucleotide catabolic process (GO:0006244)6.02119647
6retinal cone cell development (GO:0046549)5.87180796
7protein K6-linked ubiquitination (GO:0085020)5.54239396
8mitotic metaphase plate congression (GO:0007080)5.54166476
9female gamete generation (GO:0007292)5.21500466
10mitotic chromosome condensation (GO:0007076)5.20246844
11DNA methylation involved in gamete generation (GO:0043046)5.09698856
12regulation of acrosome reaction (GO:0060046)4.91870063
13multicellular organism reproduction (GO:0032504)4.89833155
14protein localization to kinetochore (GO:0034501)4.87433584
15notochord development (GO:0030903)4.82769574
16detection of light stimulus involved in visual perception (GO:0050908)4.75004768
17detection of light stimulus involved in sensory perception (GO:0050962)4.75004768
18regulation of meiosis (GO:0040020)4.65421802
19metaphase plate congression (GO:0051310)4.52405412
20protein localization to chromosome, centromeric region (GO:0071459)4.47566024
21histone H2A ubiquitination (GO:0033522)4.40671385
22positive regulation of gastrulation (GO:2000543)4.37486708
23behavioral response to nicotine (GO:0035095)4.36477612
24endothelium development (GO:0003158)4.35914306
25gene silencing by RNA (GO:0031047)4.35509686
26negative regulation of meiosis (GO:0045835)4.30806071
27male meiosis (GO:0007140)4.29503710
28histone H2A monoubiquitination (GO:0035518)4.17084343
29DNA strand renaturation (GO:0000733)4.15627350
30pyrimidine deoxyribonucleotide metabolic process (GO:0009219)4.13796550
31establishment of chromosome localization (GO:0051303)4.13172437
32regulation of exit from mitosis (GO:0007096)4.11429852
33regulation of sister chromatid cohesion (GO:0007063)4.09278632
34reproduction (GO:0000003)4.03002695
35attachment of spindle microtubules to kinetochore (GO:0008608)4.01871182
36negative regulation of meiotic cell cycle (GO:0051447)3.99587294
37binding of sperm to zona pellucida (GO:0007339)3.95943990
38epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.88107605
39positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.87901196
40positive regulation of histone H3-K4 methylation (GO:0051571)3.87628523
41oocyte development (GO:0048599)3.86423781
42negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.84097562
43negative regulation of DNA-templated transcription, elongation (GO:0032785)3.84097562
44oogenesis (GO:0048477)3.83804041
45meiotic cell cycle (GO:0051321)3.83581963
46microtubule severing (GO:0051013)3.83510174
47mitotic sister chromatid segregation (GO:0000070)3.78134829
48glycine transport (GO:0015816)3.75289556
49regulation of histone H3-K9 methylation (GO:0051570)3.71324236
50protein complex localization (GO:0031503)3.67290268
51oocyte maturation (GO:0001556)3.61996220
52DNA alkylation (GO:0006305)3.59606190
53DNA methylation (GO:0006306)3.59606190
54regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.58937268
55regulation of meiotic cell cycle (GO:0051445)3.58158600
56negative regulation of smooth muscle cell differentiation (GO:0051151)3.57871380
57negative regulation of translation, ncRNA-mediated (GO:0040033)3.57322525
58regulation of translation, ncRNA-mediated (GO:0045974)3.57322525
59negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.57322525
60negative regulation of cell aging (GO:0090344)3.56293200
61citrulline biosynthetic process (GO:0019240)3.55986850
62negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.55251807
63centriole replication (GO:0007099)3.49231673
64transepithelial transport (GO:0070633)3.48040268
65protein localization to chromosome (GO:0034502)3.47672810
66synaptonemal complex assembly (GO:0007130)3.45248461
67regulation of spindle organization (GO:0090224)3.44806718
68urea metabolic process (GO:0019627)3.44558586
69urea cycle (GO:0000050)3.44558586
70synapsis (GO:0007129)3.42720298
71folic acid-containing compound biosynthetic process (GO:0009396)3.41923545
72protein kinase C signaling (GO:0070528)3.41866032
73negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.41313748
74protein deneddylation (GO:0000338)3.40182399
75sperm-egg recognition (GO:0035036)3.40096747
76positive regulation of chromosome segregation (GO:0051984)3.39231461
77regulation of phospholipid biosynthetic process (GO:0071071)3.36585491
78regulation of hypersensitivity (GO:0002883)3.35206590
79fertilization (GO:0009566)3.33639336
80G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.30817878
81DNA modification (GO:0006304)3.28929084
82regulation of mitotic spindle organization (GO:0060236)3.26848204
83mitotic sister chromatid cohesion (GO:0007064)3.26728291
84regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.24856650
85chaperone-mediated protein transport (GO:0072321)3.22904362
86regulation of chromosome segregation (GO:0051983)3.21822137
87primitive streak formation (GO:0090009)3.20803152
88chromosome condensation (GO:0030261)3.19484182
89histone exchange (GO:0043486)3.17229371
90somatic diversification of immune receptors via somatic mutation (GO:0002566)3.16919316
91somatic hypermutation of immunoglobulin genes (GO:0016446)3.16919316
92synaptonemal complex organization (GO:0070193)3.15793572
93deoxyribonucleotide catabolic process (GO:0009264)3.15601496
94DNA replication-dependent nucleosome organization (GO:0034723)3.15374401
95DNA replication-dependent nucleosome assembly (GO:0006335)3.15374401
96peptidyl-lysine trimethylation (GO:0018023)3.14036437
97negative regulation of histone methylation (GO:0031061)3.12758874
98eye photoreceptor cell development (GO:0042462)3.11921922
99kinetochore assembly (GO:0051382)3.11761543
100mitotic nuclear envelope disassembly (GO:0007077)3.11176965
101olfactory bulb development (GO:0021772)3.10958158
102nitrogen cycle metabolic process (GO:0071941)3.10100430
103regulation of DNA methylation (GO:0044030)3.09886621
104single fertilization (GO:0007338)3.09124220
105positive regulation of histone methylation (GO:0031062)3.08975069
106peptidyl-glutamic acid carboxylation (GO:0017187)3.04349790
107protein carboxylation (GO:0018214)3.04349790
108regulation of histone H3-K27 methylation (GO:0061085)3.04218851
109DNA replication checkpoint (GO:0000076)3.04077380
110gene silencing (GO:0016458)3.04014083
111regulation of cytokine production involved in inflammatory response (GO:1900015)3.04010813
112sister chromatid segregation (GO:0000819)3.03439994
113type B pancreatic cell development (GO:0003323)3.02809213
114negative regulation of transcription regulatory region DNA binding (GO:2000678)3.02012189
115regulation of synapse structural plasticity (GO:0051823)3.01939047
116negative regulation of reproductive process (GO:2000242)2.98555835
117photoreceptor cell development (GO:0042461)2.98384682
118deoxyribose phosphate catabolic process (GO:0046386)2.97967764
119cellular response to ATP (GO:0071318)2.97474613
120microtubule depolymerization (GO:0007019)2.96783669
121regulation of meiosis I (GO:0060631)2.96680475
122kinetochore organization (GO:0051383)2.96624400
123nuclear envelope disassembly (GO:0051081)2.96529300
124membrane disassembly (GO:0030397)2.96529300
125positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.95382730
126positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.95382730
127positive regulation of mitotic sister chromatid separation (GO:1901970)2.95382730
128cell-cell recognition (GO:0009988)2.94583041
129spindle checkpoint (GO:0031577)2.93500014
130chromatin remodeling at centromere (GO:0031055)2.93225761
131regulation of cell maturation (GO:1903429)2.92388191
132epithelial cilium movement (GO:0003351)2.92059500
133peristalsis (GO:0030432)2.91996749
134adenosine receptor signaling pathway (GO:0001973)2.91635626
135phosphorelay signal transduction system (GO:0000160)2.90009699
136negative regulation of chromosome segregation (GO:0051985)2.87780891
137cerebral cortex radially oriented cell migration (GO:0021799)2.87757977
138meiotic chromosome segregation (GO:0045132)2.87666110
139substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.86216738
140substrate-independent telencephalic tangential migration (GO:0021826)2.86216738
141meiotic cell cycle process (GO:1903046)2.86192552
142one-carbon metabolic process (GO:0006730)2.85087560
143body morphogenesis (GO:0010171)2.84776748
144centriole assembly (GO:0098534)2.83830094
145chromosome segregation (GO:0007059)2.82614327
146DNA methylation or demethylation (GO:0044728)2.82174997
147CENP-A containing nucleosome assembly (GO:0034080)2.81576000
148sulfate transmembrane transport (GO:1902358)2.80962585
149neuron fate determination (GO:0048664)2.80473150
150cell migration in hindbrain (GO:0021535)2.80380782
151positive regulation of neurological system process (GO:0031646)2.78215180
152negative regulation of cAMP-mediated signaling (GO:0043951)2.78149419
153nucleotide transmembrane transport (GO:1901679)2.76528120
154cilium or flagellum-dependent cell motility (GO:0001539)2.75452126
155purine deoxyribonucleotide catabolic process (GO:0009155)2.74969018
156regulation of histone methylation (GO:0031060)2.73048214
157cerebral cortex neuron differentiation (GO:0021895)2.68814898
158regulation of skeletal muscle contraction (GO:0014819)2.67376339
159histone H3-K4 trimethylation (GO:0080182)2.67100986
160regulation of histone H3-K4 methylation (GO:0051569)2.65139307
161regulation of calcium ion-dependent exocytosis (GO:0017158)2.64927374
162histone H3-K9 methylation (GO:0051567)2.62493736
163peptidyl-lysine methylation (GO:0018022)2.62209485

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.38537047
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.28972505
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse5.09206827
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.78011652
5BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.60225908
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.32896784
7SALL1_21062744_ChIP-ChIP_HESCs_Human3.19452455
8AR_21909140_ChIP-Seq_LNCAP_Human2.80748181
9NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.80577593
10ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.79030010
11TP63_19390658_ChIP-ChIP_HaCaT_Human2.72662201
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.59751998
13E2F4_17652178_ChIP-ChIP_JURKAT_Human2.49396783
14SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.28143771
15POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.20794857
16NANOG_18555785_ChIP-Seq_MESCs_Mouse2.18869966
17MYC_18555785_ChIP-Seq_MESCs_Mouse2.16156527
18FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.15746728
19RXR_22158963_ChIP-Seq_LIVER_Mouse2.11653564
20KAP1_22055183_ChIP-Seq_ESCs_Mouse2.07999232
21EZH2_22144423_ChIP-Seq_EOC_Human10.3485259
22DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.94794456
23E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.92002744
24NOTCH1_21737748_ChIP-Seq_TLL_Human1.89625132
25TCF3_18692474_ChIP-Seq_MESCs_Mouse1.84678907
26EGR1_23403033_ChIP-Seq_LIVER_Mouse1.84354290
27XRN2_22483619_ChIP-Seq_HELA_Human1.84097389
28ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.82393986
29TCF3_18692474_ChIP-Seq_MEFs_Mouse1.80278080
30MYCN_18555785_ChIP-Seq_MESCs_Mouse1.77005795
31P68_20966046_ChIP-Seq_HELA_Human1.75671071
32NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.71936720
33NANOG_21062744_ChIP-ChIP_HESCs_Human1.71849747
34EZH2_27304074_Chip-Seq_ESCs_Mouse1.70559846
35* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.69967295
36POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.67641084
37EWS_26573619_Chip-Seq_HEK293_Human1.63207959
38TP53_22573176_ChIP-Seq_HFKS_Human1.62161889
39* SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.61647392
40CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59818332
41MYC_19079543_ChIP-ChIP_MESCs_Mouse1.59240928
42MYC_18358816_ChIP-ChIP_MESCs_Mouse1.58056345
43KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.57465014
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.56475497
45KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.56475497
46KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.56475497
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.55690829
48NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.55090750
49CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.53758680
50CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.52103067
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.51264794
52STAT3_1855785_ChIP-Seq_MESCs_Mouse1.50222606
53EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.50060291
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.46293985
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.45626585
56NELFA_20434984_ChIP-Seq_ESCs_Mouse1.45225912
57NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.45180026
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.44462301
59KLF4_18555785_ChIP-Seq_MESCs_Mouse1.43297682
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.40835074
61NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.40468370
62* LXR_22158963_ChIP-Seq_LIVER_Mouse1.40003094
63SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.39513932
64NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.38720618
65PHF8_20622854_ChIP-Seq_HELA_Human1.38713134
66E2F1_18555785_ChIP-Seq_MESCs_Mouse1.37837467
67GATA1_26923725_Chip-Seq_HPCs_Mouse1.37279742
68KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.35482429
69E2F1_20622854_ChIP-Seq_HELA_Human1.35345362
70BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35276202
71* BCL6_27268052_Chip-Seq_Bcells_Human1.35263975
72* BCOR_27268052_Chip-Seq_Bcells_Human1.35159919
73STAT6_21828071_ChIP-Seq_BEAS2B_Human1.32960886
74NANOG_20526341_ChIP-Seq_ESCs_Human1.32409628
75NANOG_18692474_ChIP-Seq_MESCs_Mouse1.32297646
76MYC_18940864_ChIP-ChIP_HL60_Human1.31443960
77SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.30760656
78NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.29686165
79JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.29572256
80POU5F1_16518401_ChIP-PET_MESCs_Mouse1.29420115
81ZNF274_21170338_ChIP-Seq_K562_Hela1.28703458
82HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.27356572
83POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.25995993
84EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.25784819
85CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.25450674
86GBX2_23144817_ChIP-Seq_PC3_Human1.23979631
87NANOG_18692474_ChIP-Seq_MEFs_Mouse1.22490156
88VDR_21846776_ChIP-Seq_THP-1_Human1.22385405
89* CTCF_20526341_ChIP-Seq_ESCs_Human1.22312242
90* KAP1_27257070_Chip-Seq_ESCs_Mouse1.21701366
91EST1_17652178_ChIP-ChIP_JURKAT_Human1.21561921
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21471536
93MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.21212299
94GABP_19822575_ChIP-Seq_HepG2_Human1.19900671
95RNF2_27304074_Chip-Seq_NSC_Mouse1.17148640
96EZH2_27294783_Chip-Seq_ESCs_Mouse1.16301406
97CBX2_27304074_Chip-Seq_ESCs_Mouse1.15961800
98SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.13338056
99CTCF_27219007_Chip-Seq_Bcells_Human1.12949195
100ERA_21632823_ChIP-Seq_H3396_Human1.12837910
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11973770
102IRF1_19129219_ChIP-ChIP_H3396_Human1.11369598
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.09256635
104REST_21632747_ChIP-Seq_MESCs_Mouse1.09055361
105RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.07853561
106FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.07389637
107VDR_22108803_ChIP-Seq_LS180_Human1.07269872
108E2F1_17053090_ChIP-ChIP_MCF-7_Human1.06768399
109TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.06404692
110TAF2_19829295_ChIP-Seq_ESCs_Human1.06067178
111ERG_21242973_ChIP-ChIP_JURKAT_Human1.05796454
112KDM5A_27292631_Chip-Seq_BREAST_Human1.04585306
113* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04544553
114SOX2_18692474_ChIP-Seq_MESCs_Mouse1.03170547
115* OCT4_19829295_ChIP-Seq_ESCs_Human1.02505512
116RXRA_24833708_ChIP-Seq_LIVER_Mouse1.01481730
117SOX2_18692474_ChIP-Seq_MEFs_Mouse1.00880617
118TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00674149
119* MYC_19829295_ChIP-Seq_ESCs_Human0.99095408
120SOX2_18555785_ChIP-Seq_MESCs_Mouse0.98739712
121ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.97842124
122CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97363583
123NANOG_16518401_ChIP-PET_MESCs_Mouse0.97133461
124SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96944656
125GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95747554
126CTCF_21964334_Chip-Seq_Bcells_Human0.94760623
127PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94621912
128* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.94518903
129SPI1_26923725_Chip-Seq_HPCs_Mouse0.94396680
130E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.93887097
131CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.93702908
132RARA_24833708_ChIP-Seq_LIVER_Mouse0.93569276
133FOXP1_21924763_ChIP-Seq_HESCs_Human0.92942396
134GATA3_21867929_ChIP-Seq_TH1_Mouse0.92788536
135GABP_17652178_ChIP-ChIP_JURKAT_Human0.91172157
136ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90758433
137CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.90726614
138ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90352221
139* PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.90331066
140CIITA_25753668_ChIP-Seq_RAJI_Human0.90270309
141ETS1_20019798_ChIP-Seq_JURKAT_Human0.89661559
142ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89648377
143IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.89589348
144CBP_20019798_ChIP-Seq_JUKART_Human0.89589348
145IGF1R_20145208_ChIP-Seq_DFB_Human0.89585044
146GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.88667577
147ESET_19884257_ChIP-Seq_ESCs_Mouse0.88467550
148DCP1A_22483619_ChIP-Seq_HELA_Human0.88281294
149KLF4_19829295_ChIP-Seq_ESCs_Human0.88264620
150BCL6_25482012_ChIP-Seq_CML-JURL-MK1_Human0.87810414
151FUS_26573619_Chip-Seq_HEK293_Human0.87698019
152DROSHA_22980978_ChIP-Seq_HELA_Human0.87567180
153GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87352284
154P53_21459846_ChIP-Seq_SAOS-2_Human0.87098735
155SETDB1_19884257_ChIP-Seq_MESCs_Mouse0.86803080
156STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86581529
157RUNX1_26923725_Chip-Seq_HPCs_Mouse0.86204555
158P300_27268052_Chip-Seq_Bcells_Human0.86192810
159THAP11_20581084_ChIP-Seq_MESCs_Mouse0.84951029
160CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.84842438
161YY1_22570637_ChIP-Seq_MALME-3M_Human0.84674315
162* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.84484162
163RARB_24833708_ChIP-Seq_LIVER_Mouse0.83690340
164* FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.83107703
165PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82630549
166PKCTHETA_26484144_Chip-Seq_BREAST_Human0.82106837
167RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.82062770
168TBX5_21415370_ChIP-Seq_HL-1_Mouse0.81891919
169SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81616270
170WDR5_24793694_ChIP-Seq_LNCAP_Human0.81219428
171AUTS2_25519132_ChIP-Seq_293T-REX_Human0.79684550
172MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.79437954
173ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.79411379
174ATF3_27146783_Chip-Seq_COLON_Human0.79349252
175FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.79335162

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003718_maternal_effect5.94490296
2MP0003806_abnormal_nucleotide_metabolis3.82065665
3MP0003693_abnormal_embryo_hatching3.74972958
4MP0010094_abnormal_chromosome_stability3.59923203
5MP0005360_urolithiasis3.50953119
6MP0003646_muscle_fatigue3.41392583
7MP0008789_abnormal_olfactory_epithelium3.34704867
8MP0005423_abnormal_somatic_nervous3.28122904
9MP0003111_abnormal_nucleus_morphology3.25532553
10MP0004957_abnormal_blastocyst_morpholog3.14769942
11MP0008877_abnormal_DNA_methylation3.09799638
12MP0002139_abnormal_hepatobiliary_system3.07349983
13MP0002653_abnormal_ependyma_morphology3.03218665
14MP0001986_abnormal_taste_sensitivity3.01107043
15MP0001929_abnormal_gametogenesis3.00482167
16MP0005171_absent_coat_pigmentation2.99686560
17MP0005499_abnormal_olfactory_system2.89775082
18MP0005394_taste/olfaction_phenotype2.89775082
19MP0006292_abnormal_olfactory_placode2.82792444
20MP0003699_abnormal_female_reproductive2.69813244
21MP0003077_abnormal_cell_cycle2.67302469
22MP0005395_other_phenotype2.66564731
23MP0001119_abnormal_female_reproductive2.65053553
24MP0003136_yellow_coat_color2.56725586
25MP0000653_abnormal_sex_gland2.37903058
26MP0005174_abnormal_tail_pigmentation2.37544022
27MP0005085_abnormal_gallbladder_physiolo2.36927918
28MP0002210_abnormal_sex_determination2.30770503
29MP0005365_abnormal_bile_salt2.23179106
30MP0005451_abnormal_body_composition2.17145913
31MP0008875_abnormal_xenobiotic_pharmacok2.14480706
32MP0000778_abnormal_nervous_system2.06633031
33MP0005551_abnormal_eye_electrophysiolog1.92658115
34MP0002161_abnormal_fertility/fecundity1.91832771
35MP0009840_abnormal_foam_cell1.89536800
36MP0002295_abnormal_pulmonary_circulatio1.89184171
37MP0005409_darkened_coat_color1.87989922
38MP0003122_maternal_imprinting1.86948590
39MP0008057_abnormal_DNA_replication1.84375176
40MP0001502_abnormal_circadian_rhythm1.81673753
41MP0001145_abnormal_male_reproductive1.79694609
42MP0006276_abnormal_autonomic_nervous1.78997651
43MP0008932_abnormal_embryonic_tissue1.78606623
44MP0005410_abnormal_fertilization1.74622232
45MP0002938_white_spotting1.64592848
46MP0002638_abnormal_pupillary_reflex1.61744132
47MP0001730_embryonic_growth_arrest1.60874569
48MP0008058_abnormal_DNA_repair1.57384234
49MP0001968_abnormal_touch/_nociception1.52942689
50MP0003705_abnormal_hypodermis_morpholog1.52370544
51MP0003698_abnormal_male_reproductive1.50472874
52MP0001293_anophthalmia1.49519645
53MP0002234_abnormal_pharynx_morphology1.48968809
54MP0000350_abnormal_cell_proliferation1.41494449
55MP0002085_abnormal_embryonic_tissue1.39824337
56MP0002736_abnormal_nociception_after1.36444696
57MP0005380_embryogenesis_phenotype1.33625919
58MP0001672_abnormal_embryogenesis/_devel1.33625919
59MP0001188_hyperpigmentation1.33396930
60MP0000579_abnormal_nail_morphology1.32973097
61MP0000465_gastrointestinal_hemorrhage1.30825892
62MP0008260_abnormal_autophagy1.30153337
63MP0003121_genomic_imprinting1.26829557
64MP0005253_abnormal_eye_physiology1.24875869
65MP0003123_paternal_imprinting1.22531467
66MP0004264_abnormal_extraembryonic_tissu1.22046400
67MP0003787_abnormal_imprinting1.20000418
68MP0001697_abnormal_embryo_size1.19933979
69MP0002249_abnormal_larynx_morphology1.18293500
70MP0005646_abnormal_pituitary_gland1.18289141
71MP0001915_intracranial_hemorrhage1.16782891
72MP0004043_abnormal_pH_regulation1.15921720
73MP0005670_abnormal_white_adipose1.15113578
74MP0002084_abnormal_developmental_patter1.13598883
75MP0003878_abnormal_ear_physiology1.13356569
76MP0005377_hearing/vestibular/ear_phenot1.13356569
77MP0000631_abnormal_neuroendocrine_gland1.12372503
78MP0002735_abnormal_chemical_nociception1.10982971
79MP0002019_abnormal_tumor_incidence1.07039560
80MP0000015_abnormal_ear_pigmentation1.06503429
81MP0003453_abnormal_keratinocyte_physiol1.05548371
82MP0001324_abnormal_eye_pigmentation1.05193466
83MP0010234_abnormal_vibrissa_follicle1.04714432
84MP0003950_abnormal_plasma_membrane1.03738358
85MP0002932_abnormal_joint_morphology1.02276677
86MP0003890_abnormal_embryonic-extraembry1.01198486
87MP0000566_synostosis1.00546443
88MP0010329_abnormal_lipoprotein_level0.99045736
89MP0001756_abnormal_urination0.94499299
90MP0002080_prenatal_lethality0.94058299
91MP0005266_abnormal_metabolism0.92027878
92MP0002138_abnormal_hepatobiliary_system0.91155970
93MP0003252_abnormal_bile_duct0.91108021
94MP0002572_abnormal_emotion/affect_behav0.91004062
95MP0005332_abnormal_amino_acid0.90937225
96MP0005195_abnormal_posterior_eye0.90620033
97MP0005389_reproductive_system_phenotype0.90207063
98MP0002086_abnormal_extraembryonic_tissu0.87092514
99MP0002269_muscular_atrophy0.86998619
100MP0003984_embryonic_growth_retardation0.86290196
101MP0006072_abnormal_retinal_apoptosis0.84949296
102MP0002088_abnormal_embryonic_growth/wei0.84286641
103MP0005083_abnormal_biliary_tract0.83769098
104MP0004185_abnormal_adipocyte_glucose0.83729415
105MP0001486_abnormal_startle_reflex0.83485553
106MP0003861_abnormal_nervous_system0.83417458
107MP0001919_abnormal_reproductive_system0.82726273
108MP0003880_abnormal_central_pattern0.82525869
109MP0004811_abnormal_neuron_physiology0.80789111
110MP0000427_abnormal_hair_cycle0.80696575
111MP0003011_delayed_dark_adaptation0.80692613
112MP0003879_abnormal_hair_cell0.80644195
113MP0002752_abnormal_somatic_nervous0.80402502
114MP0010352_gastrointestinal_tract_polyps0.80131052
115MP0005391_vision/eye_phenotype0.79610317
116MP0003119_abnormal_digestive_system0.78342871
117MP0001666_abnormal_nutrient_absorption0.78302563
118MP0003186_abnormal_redox_activity0.77740000
119MP0003635_abnormal_synaptic_transmissio0.77552321
120MP0008995_early_reproductive_senescence0.77398044
121MP0000609_abnormal_liver_physiology0.76921162
122MP0002152_abnormal_brain_morphology0.75657036
123MP0005647_abnormal_sex_gland0.75570902
124MP0000639_abnormal_adrenal_gland0.75178047
125MP0000751_myopathy0.75121971
126MP0000490_abnormal_crypts_of0.74828923
127MP0002063_abnormal_learning/memory/cond0.74752368
128MP0006036_abnormal_mitochondrial_physio0.74684005
129MP0004133_heterotaxia0.74418808
130MP0005023_abnormal_wound_healing0.72931145
131MP0002233_abnormal_nose_morphology0.72568922
132MP0004197_abnormal_fetal_growth/weight/0.72430403
133MP0002272_abnormal_nervous_system0.71821058
134MP0002102_abnormal_ear_morphology0.70695975
135MP0008007_abnormal_cellular_replicative0.70568457
136MP0003937_abnormal_limbs/digits/tail_de0.69893902
137MP0002751_abnormal_autonomic_nervous0.68693227
138MP0001664_abnormal_digestion0.68151340
139MP0002928_abnormal_bile_duct0.66390040
140MP0002127_abnormal_cardiovascular_syste0.64616523
141MP0002734_abnormal_mechanical_nocicepti0.64217002
142MP0002282_abnormal_trachea_morphology0.63958609
143MP0002822_catalepsy0.63631334
144MP0000647_abnormal_sebaceous_gland0.63103740
145MP0001529_abnormal_vocalization0.62326380
146MP0005501_abnormal_skin_physiology0.62083741
147MP0001905_abnormal_dopamine_level0.61730099
148MP0001849_ear_inflammation0.60279563
149MP0004782_abnormal_surfactant_physiolog0.60125224
150MP0003315_abnormal_perineum_morphology0.59730921
151MP0000313_abnormal_cell_death0.59654886
152MP0010030_abnormal_orbit_morphology0.59430995
153MP0000598_abnormal_liver_morphology0.59316495
154MP0005621_abnormal_cell_physiology0.58539609
155MP0005187_abnormal_penis_morphology0.54361904
156MP0002160_abnormal_reproductive_system0.51574566
157MP0002332_abnormal_exercise_endurance0.51311779
158MP0005384_cellular_phenotype0.51199126
159MP0005257_abnormal_intraocular_pressure0.50388016
160MP0003786_premature_aging0.49707258

Predicted human phenotypes

RankGene SetZ-score
1Premature ovarian failure (HP:0008209)7.05341322
2Deep venous thrombosis (HP:0002625)6.45754282
3Cortical dysplasia (HP:0002539)6.42812350
4Male infertility (HP:0003251)6.02948412
5Birth length less than 3rd percentile (HP:0003561)5.53145453
6Infertility (HP:0000789)5.47614644
7Breast hypoplasia (HP:0003187)5.24860319
8Attenuation of retinal blood vessels (HP:0007843)4.89923314
9Abnormality of the labia minora (HP:0012880)4.25145773
10Rhabdomyosarcoma (HP:0002859)4.03856635
11Poikiloderma (HP:0001029)3.98594229
12Bony spicule pigmentary retinopathy (HP:0007737)3.90157062
13Shawl scrotum (HP:0000049)3.69558103
14Patellar aplasia (HP:0006443)3.68114262
15Hypoplastic pelvis (HP:0008839)3.57966994
16Septo-optic dysplasia (HP:0100842)3.51932350
17Capillary hemangiomas (HP:0005306)3.48000811
18Atelectasis (HP:0100750)3.40196174
19Dyschromatopsia (HP:0007641)3.38522287
20Abnormality of midbrain morphology (HP:0002418)3.37635213
21Molar tooth sign on MRI (HP:0002419)3.37635213
22Intrahepatic cholestasis (HP:0001406)3.36820893
23Neoplasm of striated muscle (HP:0009728)3.34295693
24Secondary amenorrhea (HP:0000869)3.31824708
25Aplasia/Hypoplasia of the patella (HP:0006498)3.31103049
26Aplasia of the musculature (HP:0100854)3.29899081
27Hypophosphatemic rickets (HP:0004912)3.29286057
28Pendular nystagmus (HP:0012043)3.25942109
29Testicular atrophy (HP:0000029)3.25857372
30Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.19360764
31Hypobetalipoproteinemia (HP:0003563)3.17376613
32Malnutrition (HP:0004395)3.15274309
33Impulsivity (HP:0100710)3.14286380
34Chronic hepatic failure (HP:0100626)3.12560884
35Carpal bone hypoplasia (HP:0001498)3.00563047
36Increased hepatocellular lipid droplets (HP:0006565)2.99520672
37Abnormality of monocarboxylic acid metabolism (HP:0010996)2.99289503
38Decreased central vision (HP:0007663)2.98937630
39Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.97671084
40Abnormality of lateral ventricle (HP:0030047)2.95458128
41Oligodactyly (hands) (HP:0001180)2.92812023
42Aplasia/Hypoplasia of the sternum (HP:0006714)2.91440312
43Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.87187245
44Lipid accumulation in hepatocytes (HP:0006561)2.86123437
45Congenital stationary night blindness (HP:0007642)2.85330433
46Bile duct proliferation (HP:0001408)2.80462010
47Abnormal biliary tract physiology (HP:0012439)2.80462010
48Abnormality of pyrimidine metabolism (HP:0004353)2.79829581
49Abnormality of aromatic amino acid family metabolism (HP:0004338)2.76610248
50Absent septum pellucidum (HP:0001331)2.76327367
51Medulloblastoma (HP:0002885)2.75953144
52Popliteal pterygium (HP:0009756)2.75549599
53Chromsome breakage (HP:0040012)2.74674350
54Breast aplasia (HP:0100783)2.72503280
55Myokymia (HP:0002411)2.71489797
56Fetal akinesia sequence (HP:0001989)2.70246431
57Abnormality of the intrinsic pathway (HP:0010989)2.70066342
58Facial hemangioma (HP:0000329)2.69061675
59Annular pancreas (HP:0001734)2.68565760
60Abnormality of cochlea (HP:0000375)2.67727059
61Chronic bronchitis (HP:0004469)2.64168786
62Supernumerary spleens (HP:0009799)2.63852249
63Aplasia/Hypoplasia of the breasts (HP:0010311)2.63723032
64Overlapping toe (HP:0001845)2.60232870
65Prolonged partial thromboplastin time (HP:0003645)2.60175870
66Increased number of teeth (HP:0011069)2.59534368
67Neoplasm of the oral cavity (HP:0100649)2.57022016
68Cholecystitis (HP:0001082)2.54263287
69Abnormal gallbladder physiology (HP:0012438)2.54263287
70Decreased electroretinogram (ERG) amplitude (HP:0000654)2.50220593
71Mesangial abnormality (HP:0001966)2.47448707
72Renal Fanconi syndrome (HP:0001994)2.47444350
73Rib fusion (HP:0000902)2.45282811
74Chromosomal breakage induced by crosslinking agents (HP:0003221)2.40059364
75Choroideremia (HP:0001139)2.38879750
76Abnormality of the septum pellucidum (HP:0007375)2.38079495
77Retinal dysplasia (HP:0007973)2.37810267
78Flat capital femoral epiphysis (HP:0003370)2.36343647
79Thin bony cortex (HP:0002753)2.36176784
80Turricephaly (HP:0000262)2.32482484
81Hypolipoproteinemia (HP:0010981)2.32385122
82Oral leukoplakia (HP:0002745)2.31472597
83Absent radius (HP:0003974)2.28856480
84Ependymoma (HP:0002888)2.27739520
85Tubulointerstitial nephritis (HP:0001970)2.27699027
86Abnormality of methionine metabolism (HP:0010901)2.27235391
87Joint hemorrhage (HP:0005261)2.26644511
88Type II lissencephaly (HP:0007260)2.26638616
89Abnormal sex determination (HP:0012244)2.24307964
90Sex reversal (HP:0012245)2.24307964
91Cerebellar dysplasia (HP:0007033)2.23078636
92Abnormality of aspartate family amino acid metabolism (HP:0010899)2.23077370
93Myotonia (HP:0002486)2.22807955
94Bronchiectasis (HP:0002110)2.22806987
95Abnormality of sulfur amino acid metabolism (HP:0004339)2.21875555
96Absent forearm bone (HP:0003953)2.18690552
97Aplasia involving forearm bones (HP:0009822)2.18690552
98Spastic diplegia (HP:0001264)2.13928336
99Aplasia/Hypoplasia of the fovea (HP:0008060)2.13866158
100Hypoplasia of the fovea (HP:0007750)2.13866158
101Chorioretinal atrophy (HP:0000533)2.13783149
102Xanthomatosis (HP:0000991)2.12856922
103Abnormal albumin level (HP:0012116)2.11147918
104Hypoalbuminemia (HP:0003073)2.11147918
105Neonatal onset (HP:0003623)2.10194941
106Hyperammonemia (HP:0001987)2.09864339
107Nephronophthisis (HP:0000090)2.08208733
108Rectovaginal fistula (HP:0000143)2.08168411
109Rectal fistula (HP:0100590)2.08168411
110Sloping forehead (HP:0000340)2.07773394
111Severe visual impairment (HP:0001141)2.05481092
112Abnormality of serum amino acid levels (HP:0003112)2.04949941
113Hypoplasia of the capital femoral epiphysis (HP:0003090)2.03857962
114Cystic liver disease (HP:0006706)2.03384947
115Abdominal situs inversus (HP:0003363)2.03303895
116Abnormality of abdominal situs (HP:0011620)2.03303895
117Abnormality of alanine metabolism (HP:0010916)2.01390067
118Hyperalaninemia (HP:0003348)2.01390067
119Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01390067
120Pancreatic fibrosis (HP:0100732)2.01262150
121Hypergonadotropic hypogonadism (HP:0000815)2.01054284
122Progressive inability to walk (HP:0002505)2.00856387
123Aplasia/Hypoplasia of the tongue (HP:0010295)2.00629535
124Hyperglycinemia (HP:0002154)2.00463597
125Insulin-resistant diabetes mellitus (HP:0000831)2.00192793
126Small hand (HP:0200055)1.99827115
127Hypochromic microcytic anemia (HP:0004840)1.98177485
128Cerebral hypomyelination (HP:0006808)1.97092662
129Vaginal fistula (HP:0004320)1.95468803
130Pancreatic cysts (HP:0001737)1.95302377
131Squamous cell carcinoma (HP:0002860)1.94868317
132Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.93785599
133Sandal gap (HP:0001852)1.92854936
134Hypoalphalipoproteinemia (HP:0003233)1.92313108
135Aplasia/Hypoplasia involving the musculature (HP:0001460)1.92041938
136Hyperglycemia (HP:0003074)1.91499045
137Non-midline cleft lip (HP:0100335)1.91363893
138Papillary thyroid carcinoma (HP:0002895)1.91327141
139Optic nerve hypoplasia (HP:0000609)1.90961260
140Abnormality of the fovea (HP:0000493)1.90853631
141Hypogonadotrophic hypogonadism (HP:0000044)1.90835187
142Progressive external ophthalmoplegia (HP:0000590)1.90377167
143Median cleft lip (HP:0000161)1.86989650
144Hyperglycinuria (HP:0003108)1.86757202
145Combined immunodeficiency (HP:0005387)1.86630389
146Aplasia/Hypoplasia of the macula (HP:0008059)1.85982502
147Diastasis recti (HP:0001540)1.84280251
148Akinesia (HP:0002304)1.84047451
149Delayed epiphyseal ossification (HP:0002663)1.83746079
150Anterior segment dysgenesis (HP:0007700)1.82949651
151Adrenal hypoplasia (HP:0000835)1.82599728
152Tubular atrophy (HP:0000092)1.82331994
153Colon cancer (HP:0003003)1.81455204
154Facial diplegia (HP:0001349)1.80762345
155Exertional dyspnea (HP:0002875)1.79612973
156Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.79385262
157Metaphyseal irregularity (HP:0003025)1.79349248
158Complement deficiency (HP:0004431)1.79234056
159Abnormality of the labia majora (HP:0012881)1.78904035
160Breech presentation (HP:0001623)1.77948179
161Agnosia (HP:0010524)1.77664462
162Short humerus (HP:0005792)1.75692806
163Intestinal fistula (HP:0100819)1.75664939
164Abnormality of chromosome segregation (HP:0002916)1.74529695
165Abnormality of placental membranes (HP:0011409)1.74453721
166Amniotic constriction ring (HP:0009775)1.74453721
167Selective tooth agenesis (HP:0001592)1.74317606
168Abnormality of the renal medulla (HP:0100957)1.72882429
169Small intestinal stenosis (HP:0012848)1.71925290
170Duodenal stenosis (HP:0100867)1.71925290
171Delayed puberty (HP:0000823)1.71068563
172Abnormality of the labia (HP:0000058)1.70480413
173Abnormal lung lobation (HP:0002101)1.69903369
174Abnormality of the clitoris (HP:0000056)1.69612648
175Aplasia/Hypoplasia affecting the retina (HP:0008061)1.69521406
176Epidermoid cyst (HP:0200040)1.67587794
177Upper motor neuron abnormality (HP:0002127)1.67125413
178Oligodactyly (HP:0012165)1.65550481
179Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.64355070

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAPK155.45088469
2MOS4.82736996
3MAP3K64.68796945
4BMPR24.62681867
5WNK34.50984291
6TTK4.21348886
7LATS23.14959570
8TAOK33.01309838
9TNIK2.68610509
10ERBB42.63277334
11LATS12.61278744
12BRAF2.43551170
13WNK42.42267322
14PLK42.33131074
15KSR22.28581101
16NTRK22.27995533
17STK38L2.22570332
18MAP3K92.18222058
19EEF2K2.16529910
20CDC72.13898835
21BMPR1B2.09675309
22PRKD32.06456998
23TRIM282.03005842
24ZAK2.02755073
25STK101.99234042
26EPHA41.97744637
27BUB11.96620159
28PNCK1.94133586
29BRD41.90091718
30NEK21.88725489
31CHEK21.84899698
32PLK11.80703911
33MELK1.79632008
34TGFBR11.77876045
35TAOK11.72916673
36MAPKAPK31.61396902
37MAP3K131.59547098
38MARK11.58372811
39STK161.57978773
40NEK61.49263602
41TYRO31.37581510
42PDK31.35967443
43PDK41.35967443
44AURKA1.32283030
45EIF2AK31.30729618
46CDK81.30212789
47MAP3K81.28821190
48CDK11A1.26952124
49CDK151.26733274
50WEE11.24439935
51DMPK1.20868392
52CASK1.20451788
53CDK181.19803189
54MET1.18836975
55ACVR1B1.18440563
56ARAF1.17393582
57WNK11.15668208
58SRPK11.15621841
59DYRK21.14764780
60EPHB21.09997772
61RAF11.09001229
62CDK71.06862549
63NUAK11.05150328
64CDK141.03270805
65CDK121.02289203
66AURKB1.02161359
67NEK11.01975225
68ICK1.01930678
69STK31.01735287
70RPS6KB20.92080301
71BCKDK0.90820888
72BCR0.89354842
73STK390.89179865
74CDK40.88502663
75STK380.88468015
76PRKD20.87550583
77CDK90.86593462
78CSNK1G10.84420068
79SIK20.78017545
80PINK10.76195092
81CDK50.73856201
82PDK20.72993348
83ADRBK20.72200255
84MKNK20.70220413
85NLK0.68744264
86MUSK0.67888902
87DYRK1B0.67717626
88PRKCG0.66999522
89MAPK110.64329386
90PAK60.64173196
91EIF2AK10.63566453
92OXSR10.63340015
93MAP3K40.63221906
94CHEK10.62189908
95MAPK130.61981206
96EPHA20.61229502
97TLK10.60540960
98ATM0.60022904
99ATR0.58204720
100ADRBK10.54380846
101MAP2K40.53671453
102CSNK1G30.52864253
103CDK20.52515322
104PLK30.52066319
105PRKACA0.51253270
106PKN10.50536443
107PRKAA10.50364623
108MAP3K110.49516261
109DYRK30.49183040
110PRKCZ0.48395175
111ABL20.48228362
112CAMK1G0.45014286
113BLK0.44925340
114KSR10.43574737
115RET0.43222735
116CCNB10.42368026
117GSK3B0.42124259
118MAP3K50.41366740
119EIF2AK20.40583525
120CDK10.40538998
121PRKG10.40010927
122AKT30.39126901
123MAPK80.38989706
124TESK20.38871097
125MTOR0.37616368
126CSNK1G20.37553545
127PTK20.37245617
128PIM10.37085937
129CSNK1D0.36190315
130PAK10.35744345
131PRKACB0.34930806
132BRSK20.34511713
133CSNK1A1L0.33894062
134NME10.33586484
135CDK60.31911475
136MAPK140.31901329
137STK240.31416446
138SGK2230.29772889
139MAPKAPK50.29455786
140PRKCI0.27930593
141RPS6KA10.27431346
142CSNK1E0.25485999
143PRKAA20.20318282
144PKN20.18818616
145BRSK10.17646685
146MAPK10.16602040
147TESK10.14844001
148MARK20.14572665
149RPS6KA40.13679493
150MAP3K10.13544813
151AKT10.13081358
152ABL10.12397368
153STK40.12126052
154JAK20.11273929

Predicted pathways (KEGG)

RankGene SetZ-score
1Terpenoid backbone biosynthesis_Homo sapiens_hsa009004.42429291
2Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006043.36005602
3Vitamin B6 metabolism_Homo sapiens_hsa007502.89026221
4Mismatch repair_Homo sapiens_hsa034302.80706516
5Basal transcription factors_Homo sapiens_hsa030222.72494934
6Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.61315154
7Arginine biosynthesis_Homo sapiens_hsa002202.58097385
8Phototransduction_Homo sapiens_hsa047442.54078589
9Primary bile acid biosynthesis_Homo sapiens_hsa001202.52699901
10DNA replication_Homo sapiens_hsa030302.52629512
11Cell cycle_Homo sapiens_hsa041102.49717180
12Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.44589220
13Cysteine and methionine metabolism_Homo sapiens_hsa002702.32724775
14RNA degradation_Homo sapiens_hsa030182.09736589
15Homologous recombination_Homo sapiens_hsa034402.05623696
16Base excision repair_Homo sapiens_hsa034102.05167399
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.04137527
18Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.04043462
19RNA transport_Homo sapiens_hsa030132.01796348
20Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.96969384
21Ovarian steroidogenesis_Homo sapiens_hsa049131.90909637
22One carbon pool by folate_Homo sapiens_hsa006701.88899699
23Fanconi anemia pathway_Homo sapiens_hsa034601.83765795
24Oocyte meiosis_Homo sapiens_hsa041141.75030040
25Nitrogen metabolism_Homo sapiens_hsa009101.74678919
26Biosynthesis of amino acids_Homo sapiens_hsa012301.67828685
27Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65905720
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.62842816
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.62535925
30Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.61412958
31Complement and coagulation cascades_Homo sapiens_hsa046101.52475731
32Folate biosynthesis_Homo sapiens_hsa007901.51998320
33Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.50391724
34Nucleotide excision repair_Homo sapiens_hsa034201.47824641
35RNA polymerase_Homo sapiens_hsa030201.47693804
36Non-homologous end-joining_Homo sapiens_hsa034501.47077646
37Linoleic acid metabolism_Homo sapiens_hsa005911.45032159
38Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.44434498
39alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.42338744
40Selenocompound metabolism_Homo sapiens_hsa004501.37799953
41Vitamin digestion and absorption_Homo sapiens_hsa049771.34530302
42Pyruvate metabolism_Homo sapiens_hsa006201.33224221
43mRNA surveillance pathway_Homo sapiens_hsa030151.31597739
44Drug metabolism - other enzymes_Homo sapiens_hsa009831.30260605
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.26696425
46Nicotine addiction_Homo sapiens_hsa050331.25851822
47Taste transduction_Homo sapiens_hsa047421.24490587
48Tryptophan metabolism_Homo sapiens_hsa003801.20475103
49Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.20192368
50Propanoate metabolism_Homo sapiens_hsa006401.17593018
51Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.13061410
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.12641423
53Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.12542927
54Fatty acid degradation_Homo sapiens_hsa000711.10604066
55Circadian rhythm_Homo sapiens_hsa047101.09897865
562-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.09801039
57Arginine and proline metabolism_Homo sapiens_hsa003301.07440639
58Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.06245914
59Pyrimidine metabolism_Homo sapiens_hsa002401.05193889
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.03070178
61Chemical carcinogenesis_Homo sapiens_hsa052041.00329934
62Peroxisome_Homo sapiens_hsa041460.99728112
63Fatty acid biosynthesis_Homo sapiens_hsa000610.98831153
64TGF-beta signaling pathway_Homo sapiens_hsa043500.97360437
65Other glycan degradation_Homo sapiens_hsa005110.96897395
66Basal cell carcinoma_Homo sapiens_hsa052170.95135792
67Retinol metabolism_Homo sapiens_hsa008300.91188373
68Pentose and glucuronate interconversions_Homo sapiens_hsa000400.89232228
69Gap junction_Homo sapiens_hsa045400.88994938
70Olfactory transduction_Homo sapiens_hsa047400.87565543
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.87399358
72Cyanoamino acid metabolism_Homo sapiens_hsa004600.83700441
73Fatty acid metabolism_Homo sapiens_hsa012120.82037603
74PPAR signaling pathway_Homo sapiens_hsa033200.80397262
75Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.79008151
76Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.78798437
77beta-Alanine metabolism_Homo sapiens_hsa004100.78489120
78Dorso-ventral axis formation_Homo sapiens_hsa043200.78211484
79Lysine degradation_Homo sapiens_hsa003100.76727729
80p53 signaling pathway_Homo sapiens_hsa041150.76624940
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76453875
82Steroid hormone biosynthesis_Homo sapiens_hsa001400.74391976
83Histidine metabolism_Homo sapiens_hsa003400.72958453
84Sphingolipid metabolism_Homo sapiens_hsa006000.70217162
85Axon guidance_Homo sapiens_hsa043600.70199139
86Carbon metabolism_Homo sapiens_hsa012000.67429270
87Glycerophospholipid metabolism_Homo sapiens_hsa005640.67422521
88Bile secretion_Homo sapiens_hsa049760.67328486
89Spliceosome_Homo sapiens_hsa030400.65606345
90Morphine addiction_Homo sapiens_hsa050320.64209127
91MicroRNAs in cancer_Homo sapiens_hsa052060.63341486
92Caffeine metabolism_Homo sapiens_hsa002320.62664811
93Pancreatic cancer_Homo sapiens_hsa052120.62580136
94Glutathione metabolism_Homo sapiens_hsa004800.61919659
95Glutamatergic synapse_Homo sapiens_hsa047240.61149023
96Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61143226
97Huntingtons disease_Homo sapiens_hsa050160.60662344
98Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.60388556
99Sulfur relay system_Homo sapiens_hsa041220.60297302
100Glycerolipid metabolism_Homo sapiens_hsa005610.59497793
101Ether lipid metabolism_Homo sapiens_hsa005650.58883526
102Purine metabolism_Homo sapiens_hsa002300.58101086
103mTOR signaling pathway_Homo sapiens_hsa041500.57823125
104Maturity onset diabetes of the young_Homo sapiens_hsa049500.57603744
105Butanoate metabolism_Homo sapiens_hsa006500.56403994
106Hippo signaling pathway_Homo sapiens_hsa043900.55022369
107GABAergic synapse_Homo sapiens_hsa047270.52302046
108Colorectal cancer_Homo sapiens_hsa052100.51382075
109Notch signaling pathway_Homo sapiens_hsa043300.51214132
110Inositol phosphate metabolism_Homo sapiens_hsa005620.48465899
111Cocaine addiction_Homo sapiens_hsa050300.47496851
112Steroid biosynthesis_Homo sapiens_hsa001000.45737745
113Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.44511817
114Tyrosine metabolism_Homo sapiens_hsa003500.44202926
115Glycosaminoglycan degradation_Homo sapiens_hsa005310.42667294
116Wnt signaling pathway_Homo sapiens_hsa043100.41815830
117Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.41352109
118Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.40194987
119Bladder cancer_Homo sapiens_hsa052190.39305822
120Melanogenesis_Homo sapiens_hsa049160.38217115
121ABC transporters_Homo sapiens_hsa020100.37625167
122Hedgehog signaling pathway_Homo sapiens_hsa043400.33863163
123Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.33419709
124Glucagon signaling pathway_Homo sapiens_hsa049220.32745869
125Regulation of autophagy_Homo sapiens_hsa041400.32352134
126Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.32244521
127Longevity regulating pathway - mammal_Homo sapiens_hsa042110.30421853
128Staphylococcus aureus infection_Homo sapiens_hsa051500.30309318
129Metabolic pathways_Homo sapiens_hsa011000.29622511
130Fat digestion and absorption_Homo sapiens_hsa049750.29607988
131Phenylalanine metabolism_Homo sapiens_hsa003600.27417741
132GnRH signaling pathway_Homo sapiens_hsa049120.26271680
133Alcoholism_Homo sapiens_hsa050340.25603990
134Cholinergic synapse_Homo sapiens_hsa047250.23951412
135Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.23423416
136Synaptic vesicle cycle_Homo sapiens_hsa047210.21398769
137Serotonergic synapse_Homo sapiens_hsa047260.20659776
138cAMP signaling pathway_Homo sapiens_hsa040240.19971863
139Calcium signaling pathway_Homo sapiens_hsa040200.18802368

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