CPSF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one subunit of a cleavage factor required for 3' RNA cleavage and polyadenylation processing. The interaction of the protein with the RNA is one of the earliest steps in the assembly of the 3' end processing complex and facilitates the recruitment of other processing factors. The cleavage factor complex is composed of four polypeptides. This gene encodes the 68kD subunit. It has a domain organization reminiscent of spliceosomal proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)4.91536830
2mitotic sister chromatid cohesion (GO:0007064)4.18786954
3negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.15691853
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.14374211
5protein localization to kinetochore (GO:0034501)4.01911602
6negative regulation of histone methylation (GO:0031061)4.01222025
7negative regulation of RNA splicing (GO:0033119)3.97628120
8nuclear pore organization (GO:0006999)3.92989098
9nuclear pore complex assembly (GO:0051292)3.89324112
10kinetochore organization (GO:0051383)3.86861366
11DNA topological change (GO:0006265)3.83049210
12regulation of histone H3-K9 methylation (GO:0051570)3.82304280
13non-recombinational repair (GO:0000726)3.81092100
14double-strand break repair via nonhomologous end joining (GO:0006303)3.81092100
15sister chromatid segregation (GO:0000819)3.73499109
16pre-miRNA processing (GO:0031054)3.73225482
17mitotic chromosome condensation (GO:0007076)3.68108749
18dosage compensation (GO:0007549)3.68094131
19mRNA splice site selection (GO:0006376)3.60047816
20DNA replication checkpoint (GO:0000076)3.58645238
21regulation of sister chromatid cohesion (GO:0007063)3.58517170
22histone H2A acetylation (GO:0043968)3.55253491
23DNA duplex unwinding (GO:0032508)3.52673107
24negative regulation of mRNA processing (GO:0050686)3.52503174
25protein localization to chromosome, centromeric region (GO:0071459)3.52064767
26DNA replication initiation (GO:0006270)3.51462195
27DNA geometric change (GO:0032392)3.50911936
28somatic diversification of immune receptors via somatic mutation (GO:0002566)3.46825264
29somatic hypermutation of immunoglobulin genes (GO:0016446)3.46825264
30nucleosome disassembly (GO:0006337)3.41044937
31protein-DNA complex disassembly (GO:0032986)3.41044937
32DNA replication-dependent nucleosome organization (GO:0034723)3.39169784
33DNA replication-dependent nucleosome assembly (GO:0006335)3.39169784
34regulation of DNA endoreduplication (GO:0032875)3.34015621
35mitotic sister chromatid segregation (GO:0000070)3.29849403
36DNA replication-independent nucleosome assembly (GO:0006336)3.29762988
37DNA replication-independent nucleosome organization (GO:0034724)3.29762988
38DNA strand elongation involved in DNA replication (GO:0006271)3.26990350
39DNA ligation (GO:0006266)3.26726700
40positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.26048755
41positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.26048755
42positive regulation of mitotic sister chromatid separation (GO:1901970)3.26048755
43ATP-dependent chromatin remodeling (GO:0043044)3.25269355
44IMP biosynthetic process (GO:0006188)3.24582022
45kinetochore assembly (GO:0051382)3.24107685
46establishment of integrated proviral latency (GO:0075713)3.21972002
47mitotic recombination (GO:0006312)3.19462320
48CENP-A containing nucleosome assembly (GO:0034080)3.18320561
49regulation of RNA export from nucleus (GO:0046831)3.17433743
50DNA strand elongation (GO:0022616)3.17313485
51negative regulation of DNA recombination (GO:0045910)3.17285617
52chromatin remodeling at centromere (GO:0031055)3.17066774
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.12950611
54regulation of telomere maintenance via telomerase (GO:0032210)3.12210345
55mitotic nuclear envelope disassembly (GO:0007077)3.11150025
56protein localization to chromosome (GO:0034502)3.10079645
57mitotic metaphase plate congression (GO:0007080)3.05211064
58V(D)J recombination (GO:0033151)3.03417511
59positive regulation of chromosome segregation (GO:0051984)3.03279972
60RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)3.02562795
61mRNA splicing, via spliceosome (GO:0000398)3.02562795
62chromatin assembly or disassembly (GO:0006333)3.02279859
63attachment of spindle microtubules to kinetochore (GO:0008608)3.01938497
64interkinetic nuclear migration (GO:0022027)3.01737715
65regulation of mRNA splicing, via spliceosome (GO:0048024)3.01254741
66viral mRNA export from host cell nucleus (GO:0046784)3.00989111
67RNA splicing, via transesterification reactions (GO:0000375)3.00856602
68regulation of DNA damage checkpoint (GO:2000001)3.00386918
69nucleotide-excision repair, DNA gap filling (GO:0006297)2.99651152
70regulation of centrosome cycle (GO:0046605)2.99390606
71regulation of centriole replication (GO:0046599)2.98302223
72negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.98121940
73negative regulation of translation, ncRNA-mediated (GO:0040033)2.98121940
74regulation of translation, ncRNA-mediated (GO:0045974)2.98121940
75regulation of centrosome duplication (GO:0010824)2.97461768
76membrane disassembly (GO:0030397)2.96283948
77nuclear envelope disassembly (GO:0051081)2.96283948
78spindle assembly checkpoint (GO:0071173)2.95829836
79regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.95815006
80regulation of mitotic spindle checkpoint (GO:1903504)2.95815006
81regulation of nuclear cell cycle DNA replication (GO:0033262)2.95328648
82positive regulation of histone H3-K4 methylation (GO:0051571)2.95323939
83telomere maintenance via semi-conservative replication (GO:0032201)2.94911212
84termination of RNA polymerase II transcription (GO:0006369)2.94425879
85DNA conformation change (GO:0071103)2.94403385
86regulation of chromosome segregation (GO:0051983)2.93346941
87microtubule depolymerization (GO:0007019)2.92080421
88alternative mRNA splicing, via spliceosome (GO:0000380)2.91872311
89DNA double-strand break processing (GO:0000729)2.91768235
90negative regulation of DNA-dependent DNA replication (GO:2000104)2.91430591
91spindle checkpoint (GO:0031577)2.91301971
92regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91200471
93formation of translation preinitiation complex (GO:0001731)2.90739129
94positive regulation of cell cycle checkpoint (GO:1901978)2.90494446
95metaphase plate congression (GO:0051310)2.89311102
96negative regulation of mRNA metabolic process (GO:1903312)2.89013437
97regulation of sister chromatid segregation (GO:0033045)2.88723016
98regulation of mitotic sister chromatid separation (GO:0010965)2.88723016
99regulation of mitotic sister chromatid segregation (GO:0033047)2.88723016
100negative regulation of chromosome segregation (GO:0051985)2.88433071
101negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.88360577
102negative regulation of sister chromatid segregation (GO:0033046)2.88360577
103negative regulation of mitotic sister chromatid separation (GO:2000816)2.88360577
104negative regulation of mitotic sister chromatid segregation (GO:0033048)2.88360577
105mitotic spindle assembly checkpoint (GO:0007094)2.87562647
106pore complex assembly (GO:0046931)2.87316344
107telomere maintenance via recombination (GO:0000722)2.87287230
108translesion synthesis (GO:0019985)2.86075665
109RNA export from nucleus (GO:0006405)2.85910936
110RNA transport (GO:0050658)2.84896218
111establishment of RNA localization (GO:0051236)2.84896218
112nucleic acid transport (GO:0050657)2.84896218
113maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.84847331
114ribosome assembly (GO:0042255)2.84485238
115chromatin assembly (GO:0031497)2.83967812
116regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.82955602
117mRNA export from nucleus (GO:0006406)2.82301660
118spliceosomal tri-snRNP complex assembly (GO:0000244)2.81083795
119postreplication repair (GO:0006301)2.80080528
120histone exchange (GO:0043486)2.79949993
121mitotic spindle checkpoint (GO:0071174)2.79568944
122regulation of helicase activity (GO:0051095)2.79212465
123regulation of telomere maintenance (GO:0032204)2.79122453
124negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.77774274
125mRNA transport (GO:0051028)2.76231093
126nucleosome organization (GO:0034728)2.73918737
127mRNA stabilization (GO:0048255)2.72197292
128RNA stabilization (GO:0043489)2.72197292

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human5.46642644
2E2F4_17652178_ChIP-ChIP_JURKAT_Human4.63799057
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.80946523
4RBPJ_22232070_ChIP-Seq_NCS_Mouse3.57302702
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.32328421
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.19260126
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.18978319
8TP63_19390658_ChIP-ChIP_HaCaT_Human3.05947286
9MYC_18555785_ChIP-Seq_MESCs_Mouse3.01505759
10SALL1_21062744_ChIP-ChIP_HESCs_Human2.83941654
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.59071584
12E2F1_21310950_ChIP-Seq_MCF-7_Human2.47449995
13* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.26861599
14CIITA_25753668_ChIP-Seq_RAJI_Human2.20041854
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17557434
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.16782387
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.10631065
18MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.09365862
19MYC_22102868_ChIP-Seq_BL_Human2.08442855
20* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.00695020
21E2F7_22180533_ChIP-Seq_HELA_Human10.7764727
22SOX2_18555785_ChIP-Seq_MESCs_Mouse1.91570072
23IGF1R_20145208_ChIP-Seq_DFB_Human1.90216799
24MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.88838487
25XRN2_22483619_ChIP-Seq_HELA_Human1.79871721
26EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.79260711
27PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75585124
28MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.71560687
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69110248
30EST1_17652178_ChIP-ChIP_JURKAT_Human1.60682045
31AR_21909140_ChIP-Seq_LNCAP_Human1.60194670
32HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.59519742
33VDR_23849224_ChIP-Seq_CD4+_Human1.58439501
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.58330039
35POU3F2_20337985_ChIP-ChIP_501MEL_Human1.57173931
36POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55348796
37POU5F1_16153702_ChIP-ChIP_HESCs_Human1.54325738
38ELK1_19687146_ChIP-ChIP_HELA_Human1.51403879
39SOX2_16153702_ChIP-ChIP_HESCs_Human1.50144921
40FOXP3_21729870_ChIP-Seq_TREG_Human1.49306513
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.48906545
42THAP11_20581084_ChIP-Seq_MESCs_Mouse1.48184262
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.47022051
44KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.46178354
45ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.42956153
46TTF2_22483619_ChIP-Seq_HELA_Human1.40851052
47IRF1_19129219_ChIP-ChIP_H3396_Human1.37841305
48KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.36758088
49KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.36758088
50KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.36758088
51PADI4_21655091_ChIP-ChIP_MCF-7_Human1.36470385
52* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.35051226
53SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.33948990
54* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33650042
55* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.31341051
56CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31072653
57SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.27523439
58SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.27482258
59* KDM5A_27292631_Chip-Seq_BREAST_Human1.27424754
60PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.27386420
61FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.27336123
62KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25509869
63ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.24170849
64* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.23340846
65ETS1_20019798_ChIP-Seq_JURKAT_Human1.22654784
66* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.22391831
67E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.20780587
68EWS_26573619_Chip-Seq_HEK293_Human1.19436223
69PKCTHETA_26484144_Chip-Seq_BREAST_Human1.18148213
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.16342587
71ZNF274_21170338_ChIP-Seq_K562_Hela1.13339477
72CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12338044
73GABP_19822575_ChIP-Seq_HepG2_Human1.09634970
74TAF15_26573619_Chip-Seq_HEK293_Human1.08506127
75DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.08067212
76FUS_26573619_Chip-Seq_HEK293_Human1.06235763
77POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06167407
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06122264
79NANOG_16153702_ChIP-ChIP_HESCs_Human1.05354972
80TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05176752
81TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04892937
82GABP_17652178_ChIP-ChIP_JURKAT_Human1.04777056
83* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.00284221
84DCP1A_22483619_ChIP-Seq_HELA_Human1.00026039
85MYC_18940864_ChIP-ChIP_HL60_Human0.99452850
86FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.99447140
87ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99446445
88NANOG_18555785_ChIP-Seq_MESCs_Mouse0.99396749
89* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99396370
90E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98622110
91RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97002940
92BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.94800012
93POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.92140109
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human0.91644915
95NOTCH1_21737748_ChIP-Seq_TLL_Human0.90725818
96* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.88557910
97* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.87845127
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.85926773
99SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.85623441
100SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.85616399
101SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.85583977
102CHD1_26751641_Chip-Seq_LNCaP_Human0.85563431
103GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.85489650
104NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.85297924
105SOX9_26525672_Chip-Seq_HEART_Mouse0.84564104
106JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.84402911
107SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.83767743
108NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.82576632
109* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.81582047
110TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.80975184
111CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.80485396
112NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.79498913
113ESR1_15608294_ChIP-ChIP_MCF-7_Human0.78280241
114* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.77084558
115ZFP281_18757296_ChIP-ChIP_E14_Mouse0.76180502
116TCF3_18692474_ChIP-Seq_MESCs_Mouse0.75116844
117CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.71912135

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.59886711
2MP0003111_abnormal_nucleus_morphology3.09525924
3MP0003121_genomic_imprinting3.08474538
4MP0003787_abnormal_imprinting2.92382059
5MP0008057_abnormal_DNA_replication2.87333240
6MP0003693_abnormal_embryo_hatching2.82545728
7MP0003123_paternal_imprinting2.80920008
8MP0003077_abnormal_cell_cycle2.77899797
9MP0004957_abnormal_blastocyst_morpholog2.53799985
10MP0001188_hyperpigmentation2.35373170
11MP0000569_abnormal_digit_pigmentation2.32270286
12MP0008058_abnormal_DNA_repair2.31528208
13MP0006292_abnormal_olfactory_placode2.28366391
14MP0008789_abnormal_olfactory_epithelium2.22641641
15MP0008007_abnormal_cellular_replicative2.18756849
16MP0003890_abnormal_embryonic-extraembry2.15245948
17MP0010030_abnormal_orbit_morphology1.95375057
18MP0008877_abnormal_DNA_methylation1.94335305
19MP0005394_taste/olfaction_phenotype1.93215290
20MP0005499_abnormal_olfactory_system1.93215290
21MP0000537_abnormal_urethra_morphology1.90191709
22MP0001293_anophthalmia1.83586419
23MP0008932_abnormal_embryonic_tissue1.77442927
24MP0000350_abnormal_cell_proliferation1.77006125
25MP0003122_maternal_imprinting1.68879773
26MP0009697_abnormal_copulation1.68373086
27MP0002084_abnormal_developmental_patter1.63447957
28MP0001730_embryonic_growth_arrest1.63047360
29MP0002396_abnormal_hematopoietic_system1.62755541
30MP0002085_abnormal_embryonic_tissue1.59573594
31MP0002938_white_spotting1.53857309
32MP0003937_abnormal_limbs/digits/tail_de1.53063519
33MP0001672_abnormal_embryogenesis/_devel1.49099199
34MP0005380_embryogenesis_phenotype1.49099199
35MP0001697_abnormal_embryo_size1.46861438
36MP0004197_abnormal_fetal_growth/weight/1.44085975
37MP0003119_abnormal_digestive_system1.43227995
38MP0010352_gastrointestinal_tract_polyps1.41069939
39MP0003567_abnormal_fetal_cardiomyocyte1.40912514
40MP0003861_abnormal_nervous_system1.39946942
41MP0008995_early_reproductive_senescence1.39814298
42MP0002822_catalepsy1.39289461
43MP0004808_abnormal_hematopoietic_stem1.36747359
44MP0000049_abnormal_middle_ear1.35123918
45MP0003984_embryonic_growth_retardation1.34568915
46MP0002088_abnormal_embryonic_growth/wei1.33953139
47MP0003935_abnormal_craniofacial_develop1.32086869
48MP0000566_synostosis1.30623586
49MP0000778_abnormal_nervous_system1.25389583
50MP0009053_abnormal_anal_canal1.23666160
51MP0001286_abnormal_eye_development1.23591317
52MP0005076_abnormal_cell_differentiation1.23491306
53MP0002086_abnormal_extraembryonic_tissu1.22699338
54MP0003938_abnormal_ear_development1.22044307
55MP0002080_prenatal_lethality1.21263253
56MP0010307_abnormal_tumor_latency1.20331638
57MP0003115_abnormal_respiratory_system1.18329705
58MP0003385_abnormal_body_wall1.18318013
59MP0003755_abnormal_palate_morphology1.15913326
60MP0005187_abnormal_penis_morphology1.14613825
61MP0001346_abnormal_lacrimal_gland1.13485955
62MP0002249_abnormal_larynx_morphology1.11418552
63MP0009703_decreased_birth_body1.10395152
64MP0003315_abnormal_perineum_morphology1.10330251
65MP0002102_abnormal_ear_morphology1.10249566
66MP0003941_abnormal_skin_development1.09193948
67MP0002092_abnormal_eye_morphology1.07551047
68MP0000703_abnormal_thymus_morphology1.06524174
69MP0000428_abnormal_craniofacial_morphol1.06303916
70MP0003718_maternal_effect1.06041694
71MP0002233_abnormal_nose_morphology1.05229021
72MP0003942_abnormal_urinary_system1.05094249
73MP0002095_abnormal_skin_pigmentation1.05047650
74MP0005174_abnormal_tail_pigmentation1.04849653
75MP0000631_abnormal_neuroendocrine_gland1.04074483
76MP0001177_atelectasis1.03881261
77MP0002163_abnormal_gland_morphology1.03796631
78MP0002751_abnormal_autonomic_nervous1.02223270
79MP0002697_abnormal_eye_size1.01669745
80MP0003763_abnormal_thymus_physiology1.00808081
81MP0002081_perinatal_lethality0.99398191
82MP0003221_abnormal_cardiomyocyte_apopto0.97609156
83MP0000490_abnormal_crypts_of0.97352305
84MP0002116_abnormal_craniofacial_bone0.95759356
85MP0002932_abnormal_joint_morphology0.95486047
86MP0000432_abnormal_head_morphology0.94083836
87MP0000516_abnormal_urinary_system0.94028498
88MP0005367_renal/urinary_system_phenotyp0.94028498
89MP0002111_abnormal_tail_morphology0.92414730
90MP0000313_abnormal_cell_death0.90690876
91MP0002114_abnormal_axial_skeleton0.90434821
92MP0005220_abnormal_exocrine_pancreas0.90428104
93MP0001849_ear_inflammation0.90148312
94MP0003786_premature_aging0.89658513
95MP0009672_abnormal_birth_weight0.88995988
96MP0001529_abnormal_vocalization0.88908352
97MP0002177_abnormal_outer_ear0.87704865
98MP0002009_preneoplasia0.87403222
99MP0003943_abnormal_hepatobiliary_system0.86293532
100MP0001929_abnormal_gametogenesis0.85970865
101MP0002160_abnormal_reproductive_system0.85916119
102MP0004133_heterotaxia0.84929371
103MP0002210_abnormal_sex_determination0.83756396
104MP0002152_abnormal_brain_morphology0.81303373
105MP0001145_abnormal_male_reproductive0.80934304
106MP0000678_abnormal_parathyroid_gland0.80605311
107MP0002234_abnormal_pharynx_morphology0.79443675
108MP0005391_vision/eye_phenotype0.79430953
109MP0000015_abnormal_ear_pigmentation0.75886400
110MP0002653_abnormal_ependyma_morphology0.75589368
111MP0006054_spinal_hemorrhage0.74579307
112MP0005253_abnormal_eye_physiology0.74337102
113MP0002075_abnormal_coat/hair_pigmentati0.73109419
114MP0002184_abnormal_innervation0.72665091
115MP0000653_abnormal_sex_gland0.72112290
116MP0001485_abnormal_pinna_reflex0.71842702
117MP0006072_abnormal_retinal_apoptosis0.71641865
118MP0001340_abnormal_eyelid_morphology0.71001437
119MP0001299_abnormal_eye_distance/0.70567492
120MP0002019_abnormal_tumor_incidence0.70427315
121MP0010368_abnormal_lymphatic_system0.69394826
122MP0003698_abnormal_male_reproductive0.66011516
123MP0005645_abnormal_hypothalamus_physiol0.64045982
124MP0008770_decreased_survivor_rate0.63775294

Predicted human phenotypes

RankGene SetZ-score
1Volvulus (HP:0002580)3.52431557
2Short 4th metacarpal (HP:0010044)3.35494758
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.35494758
4Abnormality of the fingertips (HP:0001211)3.24535761
5Colon cancer (HP:0003003)3.14672816
6Medulloblastoma (HP:0002885)3.08229323
7Patellar aplasia (HP:0006443)2.85701061
8Abnormality of the labia minora (HP:0012880)2.79554310
9Increased nuchal translucency (HP:0010880)2.75111903
10Aplasia/Hypoplasia of the patella (HP:0006498)2.68088597
11Chromsome breakage (HP:0040012)2.67705257
12Acute lymphatic leukemia (HP:0006721)2.64564473
13Cortical dysplasia (HP:0002539)2.63075665
14Chromosomal breakage induced by crosslinking agents (HP:0003221)2.62248377
15Neoplasm of the adrenal cortex (HP:0100641)2.59890321
16Ependymoma (HP:0002888)2.55347837
17Birth length less than 3rd percentile (HP:0003561)2.40592931
18Aplasia/Hypoplasia of the sternum (HP:0006714)2.37570594
19Abnormal number of incisors (HP:0011064)2.35903189
20Nephroblastoma (Wilms tumor) (HP:0002667)2.34600261
21Hepatoblastoma (HP:0002884)2.32303880
22Abnormality of the intervertebral disk (HP:0005108)2.30450349
23Renal duplication (HP:0000075)2.29803902
24Trigonocephaly (HP:0000243)2.27858884
25Abnormality of chromosome stability (HP:0003220)2.25777159
26Embryonal renal neoplasm (HP:0011794)2.25637736
27Acute myeloid leukemia (HP:0004808)2.23028005
28Astrocytoma (HP:0009592)2.21411524
29Abnormality of the astrocytes (HP:0100707)2.21411524
30Ectopic kidney (HP:0000086)2.19803508
31Meckel diverticulum (HP:0002245)2.18530880
32Abnormality of the 4th metacarpal (HP:0010012)2.16867100
33Abnormality of cochlea (HP:0000375)2.15076820
34Aqueductal stenosis (HP:0002410)2.14075226
35Abnormality of the ileum (HP:0001549)2.13122675
36Pelvic girdle muscle weakness (HP:0003749)2.13068914
37Cutis marmorata (HP:0000965)2.10861507
38Long eyelashes (HP:0000527)2.10342127
39Aplasia/Hypoplasia of the uvula (HP:0010293)2.09666166
40Obsessive-compulsive behavior (HP:0000722)2.09559316
41Stenosis of the external auditory canal (HP:0000402)2.07049804
42Myelodysplasia (HP:0002863)2.06896302
43Renovascular hypertension (HP:0100817)2.05425474
44Absent radius (HP:0003974)2.04456426
45Hyperacusis (HP:0010780)2.02987655
46Neoplasm of the oral cavity (HP:0100649)2.02454954
47Partial agenesis of the corpus callosum (HP:0001338)2.02052104
48Atresia of the external auditory canal (HP:0000413)1.99672327
49Triphalangeal thumb (HP:0001199)1.99373096
50Shoulder girdle muscle weakness (HP:0003547)1.98663041
51Abnormality of the carotid arteries (HP:0005344)1.98090894
52Abnormal lung lobation (HP:0002101)1.96911198
53Thyroid carcinoma (HP:0002890)1.96204221
54Glioma (HP:0009733)1.95907573
55Protruding tongue (HP:0010808)1.95165760
56Small intestinal stenosis (HP:0012848)1.94159066
57Duodenal stenosis (HP:0100867)1.94159066
58Selective tooth agenesis (HP:0001592)1.93493641
59Proximal placement of thumb (HP:0009623)1.93281071
60Intestinal atresia (HP:0011100)1.93213998
61Asymmetry of the thorax (HP:0001555)1.92436527
62Arteriovenous malformation (HP:0100026)1.92293109
63Neoplasm of striated muscle (HP:0009728)1.88870366
64Absent forearm bone (HP:0003953)1.88693966
65Aplasia involving forearm bones (HP:0009822)1.88693966
66Abnormality of the preputium (HP:0100587)1.87650408
67Abnormality of chromosome segregation (HP:0002916)1.87136293
68Facial hemangioma (HP:0000329)1.86330797
69Drooling (HP:0002307)1.86268628
70Deviation of the thumb (HP:0009603)1.85323688
71Malignant gastrointestinal tract tumors (HP:0006749)1.83642906
72Gastrointestinal carcinoma (HP:0002672)1.83642906
73Cutaneous finger syndactyly (HP:0010554)1.83569067
74Optic nerve coloboma (HP:0000588)1.81680680
75Clubbing of toes (HP:0100760)1.80477041
76Hypoplastic labia majora (HP:0000059)1.80279741
77Truncal obesity (HP:0001956)1.80105134
78Cutaneous syndactyly (HP:0012725)1.80078352
79Diastasis recti (HP:0001540)1.79329061
80Spina bifida occulta (HP:0003298)1.78304680
81Abnormality of the hip-girdle musculature (HP:0001445)1.76758841
82Abnormality of the musculature of the pelvis (HP:0001469)1.76758841
83Supernumerary spleens (HP:0009799)1.76658116
84Sandal gap (HP:0001852)1.76195647
85Horseshoe kidney (HP:0000085)1.75947163
86Nervous tissue neoplasm (HP:0030060)1.75287206
87Neuroectodermal neoplasm (HP:0030061)1.75287206
88Neuroepithelial neoplasm (HP:0030063)1.75287206
89Overlapping toe (HP:0001845)1.74510729
90Abnormality of the duodenum (HP:0002246)1.74187717
91Abnormality of the metopic suture (HP:0005556)1.72004233
92Skin tags (HP:0010609)1.71893239
93Overriding aorta (HP:0002623)1.71776879
94Abnormality of the parathyroid morphology (HP:0011766)1.71412679
95Morphological abnormality of the inner ear (HP:0011390)1.71120876
96Papillary thyroid carcinoma (HP:0002895)1.70640470
97Neuroblastic tumors (HP:0004376)1.70225297
98Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.70225297
99Neuroblastoma (HP:0003006)1.70225297
100Primitive neuroectodermal tumor (HP:0030065)1.70225297
101Central scotoma (HP:0000603)1.69593129
102Oligodactyly (HP:0012165)1.69273634
103Basal cell carcinoma (HP:0002671)1.68867380
104High anterior hairline (HP:0009890)1.68528214
105Neoplasm of the colon (HP:0100273)1.68241031
106Embryonal neoplasm (HP:0002898)1.67873488
107Malignant neoplasm of the central nervous system (HP:0100836)1.67487646
108Cafe-au-lait spot (HP:0000957)1.66554050
109Gonadotropin excess (HP:0000837)1.66345768
110Elfin facies (HP:0004428)1.66015088
111Esophageal atresia (HP:0002032)1.65475275
112Microtia (HP:0008551)1.65087920
113Clitoromegaly (HP:0000057)1.64975458
114Abnormality of hair growth rate (HP:0011363)1.64710670
115Slow-growing hair (HP:0002217)1.64710670
116Bilateral microphthalmos (HP:0007633)1.64700763
117Carpal bone hypoplasia (HP:0001498)1.64363404
118Midline defect of the nose (HP:0004122)1.63492693
119Excessive salivation (HP:0003781)1.63042591
120Thyroiditis (HP:0100646)1.62809223
121Impulsivity (HP:0100710)1.62331026
122Sloping forehead (HP:0000340)1.62265966
123High pitched voice (HP:0001620)1.61727756
124Deep philtrum (HP:0002002)1.61509022
125Broad palm (HP:0001169)1.61442872
126Skull defect (HP:0001362)1.61277713
127Bifid tongue (HP:0010297)1.60896664
128Preauricular skin tag (HP:0000384)1.60236700
129Prominent nose (HP:0000448)1.59627088
130Transitional cell carcinoma of the bladder (HP:0006740)1.58650471
131Broad thumb (HP:0011304)1.58392590
132Urethral obstruction (HP:0000796)1.58023838
133Tented upper lip vermilion (HP:0010804)1.57832445
134Rhabdomyosarcoma (HP:0002859)1.57357758
135Abnormality of the labia majora (HP:0012881)1.57315115
136Cupped ear (HP:0000378)1.57248038
137Aplastic anemia (HP:0001915)1.56760097
138Gastrointestinal atresia (HP:0002589)1.56453700
139Sacral dimple (HP:0000960)1.55517345
140Broad phalanges of the hand (HP:0009768)1.55382982
141Facial cleft (HP:0002006)1.55322043
142Short middle phalanx of the 5th finger (HP:0004220)1.55164609
143Abnormal hair whorl (HP:0010721)1.55137631
144Renal hypoplasia (HP:0000089)1.54302852
145Neoplasm of the pancreas (HP:0002894)1.53910101
146Absent eyebrow (HP:0002223)1.53811300
147Myelomeningocele (HP:0002475)1.53352959
148Cystic hygroma (HP:0000476)1.53150218
149Hyperglycinemia (HP:0002154)1.52950988
150Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.50323663
151Neoplasm of the adrenal gland (HP:0100631)1.49733686

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.42764817
2SRPK13.40367400
3MKNK13.06476137
4MKNK22.65727569
5WEE12.44172942
6EEF2K2.41704096
7NEK22.40710106
8BRD42.36226725
9ERBB32.31239255
10BUB12.28780300
11CDK122.25048352
12BCR2.18990689
13MAP3K102.17477707
14DYRK32.09873082
15PASK2.04750649
16STK38L1.99105989
17ATR1.97262402
18TIE11.92971633
19TAF11.91280875
20TLK11.74581358
21EIF2AK31.74377835
22RPS6KB21.73187621
23TSSK61.67297271
24TTK1.65402064
25CHEK21.62327350
26PLK31.61585002
27PLK41.56742030
28ACVR1B1.41076115
29PLK11.39329667
30CHEK11.36545752
31AURKB1.36251291
32NEK11.34861121
33CDK71.30995701
34MARK11.29756313
35MAPK131.29715916
36VRK11.29358709
37WNK31.26876472
38FGFR11.26721163
39RPS6KA41.25199529
40BRSK11.23724634
41TGFBR11.23486153
42PBK1.23081920
43STK241.22719897
44ATM1.21712585
45CDK41.21507016
46CDK61.18038704
47BRSK21.15653107
48YES11.13991620
49FGFR21.13587847
50ZAK1.12318329
51SIK21.11670621
52TRIM281.09934505
53CASK1.06522460
54CDK21.05433643
55CCNB11.01341791
56EIF2AK20.96758187
57UHMK10.96312035
58MAP3K40.96249869
59CDK10.96039993
60CDK190.93922369
61TEC0.92796276
62SMG10.92590798
63CDK80.90062673
64PKN20.90020341
65SIK30.86448385
66FLT30.85818398
67KSR10.85215768
68NTRK20.83048756
69CSNK1A1L0.81339477
70ALK0.80076713
71BMPR1B0.79056837
72MAP3K60.78759426
73VRK20.77957194
74TNIK0.77634303
75AURKA0.73905691
76MELK0.69923275
77RPS6KA50.69658158
78RPS6KB10.68330831
79STK40.67947080
80PRKDC0.66585261
81CLK10.65867255
82DYRK20.65226729
83SGK20.64648424
84NLK0.64204606
85CDK90.62434910
86MTOR0.61458051
87CDK30.60330712
88MAP4K20.59806225
89MAPK140.58688381
90MAP3K80.58213189
91AKT20.57795736
92CSNK1G30.55994549
93DYRK1B0.55911346
94PAK40.55803846
95SCYL20.54494239
96RPS6KA20.54084567
97AKT30.53546276
98PDGFRA0.52396191
99NUAK10.51764494
100CSNK1D0.50559134
101GSK3B0.50336609
102DAPK10.50016530
103TAOK20.49450188
104MAP2K70.47107484
105FGFR30.47090003
106STK30.46908795
107AKT10.46539367
108EPHA40.46334063
109MAPK100.44689767
110CAMK1G0.44351612
111HIPK20.44093812
112CSNK1E0.43880132
113CSNK2A20.43781070
114CSNK1G10.43451910
115CSNK1G20.43028769
116DYRK1A0.42070370
117LATS10.41396497
118FRK0.40651051
119CAMK1D0.40125783
120MAPK90.39725760
121MAPK80.39334102
122ERBB20.38141983
123EIF2AK10.37510154
124RPS6KL10.37412417
125RPS6KC10.37412417
126PLK20.34098856
127CSNK2A10.31560570

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.64522380
2Mismatch repair_Homo sapiens_hsa034303.33520658
3Spliceosome_Homo sapiens_hsa030403.22043719
4Cell cycle_Homo sapiens_hsa041102.87169177
5* mRNA surveillance pathway_Homo sapiens_hsa030152.60650518
6RNA transport_Homo sapiens_hsa030132.60644756
7Base excision repair_Homo sapiens_hsa034102.44514217
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.32020004
9Nucleotide excision repair_Homo sapiens_hsa034202.27482587
10Non-homologous end-joining_Homo sapiens_hsa034502.23589186
11Fanconi anemia pathway_Homo sapiens_hsa034602.22250591
12Homologous recombination_Homo sapiens_hsa034402.18436221
13Systemic lupus erythematosus_Homo sapiens_hsa053221.94766005
14Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.90394639
15RNA degradation_Homo sapiens_hsa030181.86775266
16Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.81615466
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.72433364
18Selenocompound metabolism_Homo sapiens_hsa004501.64782238
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.60281411
20One carbon pool by folate_Homo sapiens_hsa006701.57810247
21Alcoholism_Homo sapiens_hsa050341.53054930
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.52910822
23RNA polymerase_Homo sapiens_hsa030201.49915737
24Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.45967651
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.43465866
26Oocyte meiosis_Homo sapiens_hsa041141.42340741
27MicroRNAs in cancer_Homo sapiens_hsa052061.41780773
28Basal transcription factors_Homo sapiens_hsa030221.40079814
29Basal cell carcinoma_Homo sapiens_hsa052171.40073608
30Steroid biosynthesis_Homo sapiens_hsa001001.38621504
31Colorectal cancer_Homo sapiens_hsa052101.38178907
32Transcriptional misregulation in cancer_Homo sapiens_hsa052021.34719687
33Viral carcinogenesis_Homo sapiens_hsa052031.29427659
34p53 signaling pathway_Homo sapiens_hsa041151.29291918
35Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.13445113
36Chronic myeloid leukemia_Homo sapiens_hsa052201.11884602
37Notch signaling pathway_Homo sapiens_hsa043301.11523598
38HTLV-I infection_Homo sapiens_hsa051661.11502587
39Epstein-Barr virus infection_Homo sapiens_hsa051691.10980484
40Pyrimidine metabolism_Homo sapiens_hsa002401.09773216
41Hippo signaling pathway_Homo sapiens_hsa043901.09213928
42Herpes simplex infection_Homo sapiens_hsa051681.02931974
43Biosynthesis of amino acids_Homo sapiens_hsa012301.01514270
44Hedgehog signaling pathway_Homo sapiens_hsa043401.00143090
45Endometrial cancer_Homo sapiens_hsa052131.00048976
46Wnt signaling pathway_Homo sapiens_hsa043100.99645368
47Propanoate metabolism_Homo sapiens_hsa006400.96011187
48mTOR signaling pathway_Homo sapiens_hsa041500.91988038
49TGF-beta signaling pathway_Homo sapiens_hsa043500.91219924
50Small cell lung cancer_Homo sapiens_hsa052220.90989361
51Primary immunodeficiency_Homo sapiens_hsa053400.89355617
52Non-small cell lung cancer_Homo sapiens_hsa052230.88590312
53Ribosome_Homo sapiens_hsa030100.87748458
54Thyroid cancer_Homo sapiens_hsa052160.80076691
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.78016980
56Adherens junction_Homo sapiens_hsa045200.77948016
57Lysine degradation_Homo sapiens_hsa003100.76677684
58Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76276315
59Hepatitis B_Homo sapiens_hsa051610.76173292
60Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75517971
61Prostate cancer_Homo sapiens_hsa052150.74995671
62Neurotrophin signaling pathway_Homo sapiens_hsa047220.72575780
63Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71504731
64Axon guidance_Homo sapiens_hsa043600.71032991
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70625617
66T cell receptor signaling pathway_Homo sapiens_hsa046600.70187391
67Pathways in cancer_Homo sapiens_hsa052000.69926129
68Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69802430
69FoxO signaling pathway_Homo sapiens_hsa040680.69167782
70Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.68228782
71Viral myocarditis_Homo sapiens_hsa054160.67022554
72Pancreatic cancer_Homo sapiens_hsa052120.66632207
73Glioma_Homo sapiens_hsa052140.64777428
74Taste transduction_Homo sapiens_hsa047420.64648818
75Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.63819647
762-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.59798130
77Butanoate metabolism_Homo sapiens_hsa006500.58504299
78Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57678659
79Proteoglycans in cancer_Homo sapiens_hsa052050.57511343
80ErbB signaling pathway_Homo sapiens_hsa040120.57501093
81Purine metabolism_Homo sapiens_hsa002300.55872334
82B cell receptor signaling pathway_Homo sapiens_hsa046620.55408953
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.53842765
84Fatty acid biosynthesis_Homo sapiens_hsa000610.53811833
85Long-term potentiation_Homo sapiens_hsa047200.52616213
86Carbon metabolism_Homo sapiens_hsa012000.51684709
87Phototransduction_Homo sapiens_hsa047440.51646828
88Dopaminergic synapse_Homo sapiens_hsa047280.50925626
89Shigellosis_Homo sapiens_hsa051310.50117109
90Melanogenesis_Homo sapiens_hsa049160.48707433
91NF-kappa B signaling pathway_Homo sapiens_hsa040640.48248963
92Melanoma_Homo sapiens_hsa052180.47835806
93Proteasome_Homo sapiens_hsa030500.46593947
94Measles_Homo sapiens_hsa051620.44941613
95Long-term depression_Homo sapiens_hsa047300.44818846
96MAPK signaling pathway_Homo sapiens_hsa040100.44573149
97N-Glycan biosynthesis_Homo sapiens_hsa005100.44242601
98Pyruvate metabolism_Homo sapiens_hsa006200.44009010
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.42246782
100Acute myeloid leukemia_Homo sapiens_hsa052210.42209586
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.41844531
102Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41722994
103Central carbon metabolism in cancer_Homo sapiens_hsa052300.41438501
104Tight junction_Homo sapiens_hsa045300.41397039
105Apoptosis_Homo sapiens_hsa042100.41361855
106Antigen processing and presentation_Homo sapiens_hsa046120.39885168
107Prolactin signaling pathway_Homo sapiens_hsa049170.39822009
108Renal cell carcinoma_Homo sapiens_hsa052110.39616385
109PI3K-Akt signaling pathway_Homo sapiens_hsa041510.37546881
110Bladder cancer_Homo sapiens_hsa052190.37138106
111Fatty acid metabolism_Homo sapiens_hsa012120.36463435
112Rap1 signaling pathway_Homo sapiens_hsa040150.36115560
113Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35307685
114Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.34826299
115Nicotine addiction_Homo sapiens_hsa050330.34152887
116Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.33506597
117Inositol phosphate metabolism_Homo sapiens_hsa005620.33181575
118Gap junction_Homo sapiens_hsa045400.32977509
119RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.32601860
120Focal adhesion_Homo sapiens_hsa045100.32571834
121Estrogen signaling pathway_Homo sapiens_hsa049150.32035688
122Influenza A_Homo sapiens_hsa051640.31593537
123Choline metabolism in cancer_Homo sapiens_hsa052310.30998402
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29644455
125Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.22310498
126Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.21367397
127Protein export_Homo sapiens_hsa030600.21073879
128Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20777966
129AMPK signaling pathway_Homo sapiens_hsa041520.20320716
130Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20213960
131Vitamin B6 metabolism_Homo sapiens_hsa007500.18104525
132Cholinergic synapse_Homo sapiens_hsa047250.16640420

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