CPSF7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Cleavage factor Im (CFIm) is one of six factors necessary for correct cleavage and polyadenylation of pre-mRNAs. CFIm is composed of three different subunits of 25, 59, and 68 kDa, and it functions as a heterotetramer, with a dimer of the 25 kDa subunit binding to two of the 59 or 68 kDa subunits. The protein encoded by this gene represents the 59 kDa subunit, which can interact with the splicing factor U2 snRNP Auxiliary Factor (U2AF) 65 to link the splicing and polyadenylation complexes. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.90194215
2positive regulation of gamma-delta T cell activation (GO:0046645)3.90254367
33-UTR-mediated mRNA stabilization (GO:0070935)3.89658521
4negative regulation of cell killing (GO:0031342)3.83523851
5negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.83523851
6histone H3-K4 trimethylation (GO:0080182)3.80583844
7nerve growth factor signaling pathway (GO:0038180)3.69504180
8mitotic chromosome condensation (GO:0007076)3.69042799
9spliceosomal tri-snRNP complex assembly (GO:0000244)3.65518258
10positive regulation of dendritic spine morphogenesis (GO:0061003)3.64284814
11mRNA splice site selection (GO:0006376)3.61549342
12negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.59703529
13peptidyl-lysine dimethylation (GO:0018027)3.49001602
14positive regulation of RNA splicing (GO:0033120)3.45486505
15regulation of gamma-delta T cell differentiation (GO:0045586)3.43083768
16negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.41891010
17negative regulation of translation, ncRNA-mediated (GO:0040033)3.41891010
18regulation of translation, ncRNA-mediated (GO:0045974)3.41891010
19histone H3-K4 methylation (GO:0051568)3.41639351
20glomerular visceral epithelial cell development (GO:0072015)3.36979692
21dosage compensation (GO:0007549)3.27327654
22positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.24583732
23negative regulation of RNA splicing (GO:0033119)3.19874692
24embryonic process involved in female pregnancy (GO:0060136)3.19420460
25negative regulation of activin receptor signaling pathway (GO:0032926)3.19323777
26pre-miRNA processing (GO:0031054)3.17402938
27poly(A)+ mRNA export from nucleus (GO:0016973)3.14742959
28regulation of chromatin binding (GO:0035561)3.13333087
29protein localization to endosome (GO:0036010)3.08740119
30positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)3.08105029
31regulation of gamma-delta T cell activation (GO:0046643)3.07495296
32response to laminar fluid shear stress (GO:0034616)3.05707282
33COPI coating of Golgi vesicle (GO:0048205)3.04905144
34Golgi transport vesicle coating (GO:0048200)3.04905144
35positive regulation of histone deacetylation (GO:0031065)3.04613719
36positive regulation of phosphoprotein phosphatase activity (GO:0032516)3.02584273
37negative regulation of histone methylation (GO:0031061)3.01812723
38histone H3-K9 demethylation (GO:0033169)3.01568691
39activation of Rac GTPase activity (GO:0032863)3.00806944
40focal adhesion assembly (GO:0048041)2.99837424
41cell-substrate adherens junction assembly (GO:0007045)2.99837424
42intracellular estrogen receptor signaling pathway (GO:0030520)2.97467199
43apoptotic process involved in morphogenesis (GO:0060561)2.97123497
44adherens junction assembly (GO:0034333)2.96883614
45epithelial cell differentiation involved in prostate gland development (GO:0060742)2.96149770
46mitotic sister chromatid cohesion (GO:0007064)2.95548368
47mannose metabolic process (GO:0006013)2.92922744
48response to muramyl dipeptide (GO:0032495)2.92031719
49peptidyl-lysine trimethylation (GO:0018023)2.91986993
50histone H4-K16 acetylation (GO:0043984)2.91840669
51positive T cell selection (GO:0043368)2.91735557
52negative regulation of mRNA processing (GO:0050686)2.91475105
53histone lysine methylation (GO:0034968)2.91072160
54planar cell polarity pathway involved in neural tube closure (GO:0090179)2.90993419
55glomerular epithelial cell development (GO:0072310)2.87954155
56nucleosome disassembly (GO:0006337)2.86574021
57protein-DNA complex disassembly (GO:0032986)2.86574021
58positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.83477864
59cellular response to epidermal growth factor stimulus (GO:0071364)2.83178615
60regulation of mammary gland epithelial cell proliferation (GO:0033599)2.81915745
61protein export from nucleus (GO:0006611)2.81726490
62negative T cell selection (GO:0043383)2.81589107
63histone H3-K9 methylation (GO:0051567)2.81471712
64B cell receptor signaling pathway (GO:0050853)2.81159870
65cellular hyperosmotic response (GO:0071474)2.80287446
66regulation of glucose import in response to insulin stimulus (GO:2001273)2.80246256
67establishment of nucleus localization (GO:0040023)2.79119351
68peptidyl-lysine methylation (GO:0018022)2.76936931
69nuclear pore complex assembly (GO:0051292)2.76895284
70regulation of histone methylation (GO:0031060)2.74607361
71maternal placenta development (GO:0001893)2.73556826
72negative thymic T cell selection (GO:0045060)2.72989377
73regulation of mRNA splicing, via spliceosome (GO:0048024)2.72275371
74alternative mRNA splicing, via spliceosome (GO:0000380)2.70428198
75T cell selection (GO:0045058)2.70099053
76regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.69517407
77antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.69248412
78positive thymic T cell selection (GO:0045059)2.68972817
79mRNA stabilization (GO:0048255)2.68500612
80RNA stabilization (GO:0043489)2.68500612
81modulation by symbiont of host cellular process (GO:0044068)2.68204669
82signal complex assembly (GO:0007172)2.65614567
83modulation by virus of host process (GO:0019054)2.65114310
84regulation of type I interferon-mediated signaling pathway (GO:0060338)2.61670115
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.61021224
86adaptation of signaling pathway (GO:0023058)2.60801498
87response to epidermal growth factor (GO:0070849)2.60678496
88germinal center formation (GO:0002467)2.60360850
89histone demethylation (GO:0016577)2.60231608
90DNA unwinding involved in DNA replication (GO:0006268)2.58711527
91positive regulation of gene expression, epigenetic (GO:0045815)2.57820216
92regulation of histone H3-K4 methylation (GO:0051569)2.57512700
93negative regulation of mRNA metabolic process (GO:1903312)2.57129229
94regulation of establishment of planar polarity (GO:0090175)2.56847792
95cytoplasmic mRNA processing body assembly (GO:0033962)2.56039367
96pore complex assembly (GO:0046931)2.54649224
97positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.53930878
98regulation of early endosome to late endosome transport (GO:2000641)2.53125853
99histone methylation (GO:0016571)2.52939552
100trophectodermal cell differentiation (GO:0001829)2.52432366
101negative regulation of cell size (GO:0045792)2.50931561
102regulation of RNA splicing (GO:0043484)2.50904169
103histone H3-K9 modification (GO:0061647)2.50835441
104heterochromatin organization (GO:0070828)2.50765317
105regulation of RNA export from nucleus (GO:0046831)2.50578292
106glucocorticoid receptor signaling pathway (GO:0042921)2.50406143
107regulation of interleukin-12 biosynthetic process (GO:0045075)2.50360625
108negative regulation of myotube differentiation (GO:0010832)2.48178363
109regulation of NFAT protein import into nucleus (GO:0051532)2.47686582
110positive regulation by organism of defense response of other organism involved in symbiotic interact2.47227330
111modulation by symbiont of host immune response (GO:0052553)2.47227330
112positive regulation by symbiont of host defense response (GO:0052509)2.47227330
113modulation by symbiont of host defense response (GO:0052031)2.47227330
114modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.47227330
115modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.47227330
116Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.46781190
117negative regulation of gene expression, epigenetic (GO:0045814)2.45568927
118histone H4-K5 acetylation (GO:0043981)2.44358731
119histone H4-K8 acetylation (GO:0043982)2.44358731
120response to peptidoglycan (GO:0032494)2.44005518
121histone H4 deacetylation (GO:0070933)2.44000810
122definitive hemopoiesis (GO:0060216)2.43203376
123stress granule assembly (GO:0034063)2.43026975
124central nervous system projection neuron axonogenesis (GO:0021952)2.42978834
125regulation of mRNA stability (GO:0043488)2.42906368
126antigen processing and presentation of endogenous antigen (GO:0019883)2.42571659
127regulation of B cell receptor signaling pathway (GO:0050855)2.42297621
128retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.42102583
129regulation of ARF protein signal transduction (GO:0032012)2.41594015
130regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.41532792
131stress fiber assembly (GO:0043149)2.41427594
132response to nerve growth factor (GO:1990089)2.41421817
133cellular response to nerve growth factor stimulus (GO:1990090)2.41421817
134positive regulation of peptidyl-threonine phosphorylation (GO:0010800)2.39768040
135histone H3-K36 demethylation (GO:0070544)2.39510585
136positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.39344251
137leukocyte aggregation (GO:0070486)2.38773777
138regulation of mRNA processing (GO:0050684)2.38703737
139DNA topological change (GO:0006265)2.38585780
140sister chromatid segregation (GO:0000819)2.38312531
141cellular response to virus (GO:0098586)2.38115164
142regulation of histone H3-K9 methylation (GO:0051570)2.37376281
143pentose-phosphate shunt (GO:0006098)2.37173979
144modulation by virus of host morphology or physiology (GO:0019048)2.37014107
145maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.36205620
146regulation of RNA stability (GO:0043487)2.35713517
147negative regulation of necroptotic process (GO:0060546)2.34938236
148thymic T cell selection (GO:0045061)2.34742549
149positive regulation of Cdc42 GTPase activity (GO:0043089)2.33116870
150positive regulation of dendrite morphogenesis (GO:0050775)2.32410642
151histone lysine demethylation (GO:0070076)2.32312239
152regulation of telomere maintenance (GO:0032204)2.32301935
153natural killer cell differentiation (GO:0001779)2.32122693
154corticosteroid receptor signaling pathway (GO:0031958)2.31974237
155negative regulation of viral release from host cell (GO:1902187)2.31698770
156activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.31327441
157locomotory exploration behavior (GO:0035641)2.31120236
158resolution of meiotic recombination intermediates (GO:0000712)2.28907824
159regulation of mRNA metabolic process (GO:1903311)2.27223133
160histone H4 acetylation (GO:0043967)2.27210477
161regulation of histone deacetylation (GO:0031063)2.24872158
162regulation of histone H3-K27 methylation (GO:0061085)2.23479892
163regulation of nucleobase-containing compound transport (GO:0032239)2.23381226
164nuclear pore organization (GO:0006999)2.23302684
165DNA duplex unwinding (GO:0032508)2.22309855
166regulation of ARF GTPase activity (GO:0032312)2.21419904
167germ cell migration (GO:0008354)2.20562596
168regulation of intracellular estrogen receptor signaling pathway (GO:0033146)2.19730525
169NLS-bearing protein import into nucleus (GO:0006607)2.19352228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.15096493
2MYC_22102868_ChIP-Seq_BL_Human4.17632286
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.96215519
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.87444500
5FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.86882316
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.33585203
7VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.60778239
8TCF7_22412390_ChIP-Seq_EML_Mouse2.59785953
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.59736865
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.56576774
11CIITA_25753668_ChIP-Seq_RAJI_Human2.53162565
12VDR_21846776_ChIP-Seq_THP-1_Human2.48593758
13KDM2B_26808549_Chip-Seq_DND41_Human2.48198741
14KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.47624387
15GATA1_22025678_ChIP-Seq_K562_Human2.39917770
16RUNX_20019798_ChIP-Seq_JUKART_Human2.32523904
17EZH2_22144423_ChIP-Seq_EOC_Human2.23797738
18KDM2B_26808549_Chip-Seq_SUP-B15_Human2.16923766
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.14643674
20THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.11632712
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.05957891
22MAF_26560356_Chip-Seq_TH1_Human2.05716630
23* ZFP281_27345836_Chip-Seq_ESCs_Mouse2.03522143
24* DMRT1_23473982_ChIP-Seq_TESTES_Mouse2.02537841
25FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.02148071
26UTX_26944678_Chip-Seq_JUKART_Human1.96115203
27SCL_19346495_ChIP-Seq_HPC-7_Human1.93101962
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.91881928
29SPI1_23127762_ChIP-Seq_K562_Human1.91614680
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.91556741
31WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.90805308
32RACK7_27058665_Chip-Seq_MCF-7_Human1.90336166
33NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.89095589
34MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.81930640
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.81486673
36MYB_26560356_Chip-Seq_TH2_Human1.79739236
37KDM2B_26808549_Chip-Seq_JURKAT_Human1.79704217
38IKZF1_21737484_ChIP-ChIP_HCT116_Human1.77711456
39MYB_26560356_Chip-Seq_TH1_Human1.76812059
40* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.75079045
41TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.71692052
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.70204835
43IRF8_22096565_ChIP-ChIP_GC-B_Human1.70028728
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.69151381
45CLOCK_20551151_ChIP-Seq_293T_Human1.62034887
46HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.59389362
47ESR1_15608294_ChIP-ChIP_MCF-7_Human1.55169894
48* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.54995031
49VDR_24763502_ChIP-Seq_THP-1_Human1.53961711
50TP63_19390658_ChIP-ChIP_HaCaT_Human1.53053576
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.49254652
52E2F4_17652178_ChIP-ChIP_JURKAT_Human1.47848008
53RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.46785482
54RARB_27405468_Chip-Seq_BRAIN_Mouse1.44827365
55SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.44701674
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.42154945
57SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.40455004
58SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40112484
59BP1_19119308_ChIP-ChIP_Hs578T_Human1.39161546
60ELK3_25401928_ChIP-Seq_HUVEC_Human1.37688275
61FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.37499983
62EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.35884223
63CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.34944565
64PKCTHETA_26484144_Chip-Seq_BREAST_Human1.34703062
65KDM2B_26808549_Chip-Seq_K562_Human1.31618510
66HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.30906610
67CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.30479595
68STAT6_21828071_ChIP-Seq_BEAS2B_Human1.29631246
69KLF4_18555785_ChIP-Seq_MESCs_Mouse1.28271963
70E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.27703615
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27396932
72NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.25732468
73E2F1_21310950_ChIP-Seq_MCF-7_Human1.25328771
74TP53_16413492_ChIP-PET_HCT116_Human1.24978848
75RUNX1_22412390_ChIP-Seq_EML_Mouse1.24034448
76IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.22778859
77* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.22619660
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22461257
79* CREB1_26743006_Chip-Seq_LNCaP_Human1.21734113
80MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19687810
81GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.19541547
82SA1_27219007_Chip-Seq_ERYTHROID_Human1.18185994
83ZNF263_19887448_ChIP-Seq_K562_Human1.17980821
84DROSHA_22980978_ChIP-Seq_HELA_Human1.17723701
85P300_27058665_Chip-Seq_ZR-75-30cells_Human1.17480895
86P68_20966046_ChIP-Seq_HELA_Human1.16420496
87SMAD_19615063_ChIP-ChIP_OVARY_Human1.15942540
88GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15249321
89EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.14226735
90MYC_19079543_ChIP-ChIP_MESCs_Mouse1.14016981
91MAF_26560356_Chip-Seq_TH2_Human1.14001783
92SMC4_20622854_ChIP-Seq_HELA_Human1.13563151
93ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12344408
94UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11972276
95CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.10776085
96IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09969152
97DNAJC2_21179169_ChIP-ChIP_NT2_Human1.09302524
98XRN2_22483619_ChIP-Seq_HELA_Human1.08436442
99CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.08268347
100KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07885418
101KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.07731054
102FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.07376501
103ESR2_21235772_ChIP-Seq_MCF-7_Human1.06495818
104MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06295324
105ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.06232981
106SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.05841713
107IRF8_27001747_Chip-Seq_BMDM_Mouse1.05328177
108BRD4_27068464_Chip-Seq_AML-cells_Mouse1.04901348
109MYC_18555785_ChIP-Seq_MESCs_Mouse1.04726573
110PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.04427768
111TET1_21451524_ChIP-Seq_MESCs_Mouse1.03264970
112SPI1_23547873_ChIP-Seq_NB4_Human1.03111689
113STAT3_1855785_ChIP-Seq_MESCs_Mouse1.02445644
114ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.02138221
115RUNX1_27514584_Chip-Seq_MCF-7_Human1.01793547
116ATF3_27146783_Chip-Seq_COLON_Human1.00690221
117TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.00042398
118TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.99387391
119GATA1_19941827_ChIP-Seq_MEL_Mouse0.98593240
120NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97942688
121PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97610680
122LXR_22292898_ChIP-Seq_THP-1_Human0.96136846
123TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.95407850
124GATA3_27048872_Chip-Seq_THYMUS_Human0.95096132
125SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.93964084
126TBX3_20139965_ChIP-Seq_ESCs_Mouse0.93912151
127* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93407296
128NCOR1_26117541_ChIP-Seq_K562_Human0.92945394
129STAT4_19710469_ChIP-ChIP_TH1__Mouse0.92692780
130SALL1_21062744_ChIP-ChIP_HESCs_Human0.92146585
131CHD1_26751641_Chip-Seq_LNCaP_Human0.92113212
132TBX3_20139965_ChIP-Seq_MESCs_Mouse0.91889272
133SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.91714898
134ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91192995
135ERG_21242973_ChIP-ChIP_JURKAT_Human0.91087711
136TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91001144
137POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.90907119
138STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.90106953
139KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.90025541
140GATA2_22383799_ChIP-Seq_G1ME_Mouse0.89950811
141YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.89193489
142ZIC3_20872845_ChIP-ChIP_MESCs_Mouse0.88240070
143SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.86618436
144WT1_25993318_ChIP-Seq_PODOCYTE_Human0.83717549
145CTNNB1_20460455_ChIP-Seq_HCT116_Human0.82860599
146TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.82752088
147TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82471803

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation6.34313612
2MP0003705_abnormal_hypodermis_morpholog3.89998813
3MP0004859_abnormal_synaptic_plasticity2.95942349
4MP0003787_abnormal_imprinting2.88552585
5MP0008961_abnormal_basal_metabolism2.73560669
6MP0005451_abnormal_body_composition2.63854286
7MP0005174_abnormal_tail_pigmentation2.59226603
8MP0004808_abnormal_hematopoietic_stem2.43111696
9MP0005076_abnormal_cell_differentiation2.21953568
10MP0009278_abnormal_bone_marrow2.21725381
11MP0008057_abnormal_DNA_replication2.21186784
12MP0002009_preneoplasia2.14661056
13MP0003763_abnormal_thymus_physiology2.06189213
14MP0003121_genomic_imprinting2.05825992
15MP0002877_abnormal_melanocyte_morpholog2.05303267
16MP0002396_abnormal_hematopoietic_system2.01487096
17MP0008260_abnormal_autophagy1.84742244
18MP0002398_abnormal_bone_marrow1.79019541
19MP0001800_abnormal_humoral_immune1.77231117
20MP0003300_gastrointestinal_ulcer1.72219452
21MP0010352_gastrointestinal_tract_polyps1.69357349
22MP0000703_abnormal_thymus_morphology1.66485832
23MP0005058_abnormal_lysosome_morphology1.65333967
24MP0003122_maternal_imprinting1.64552036
25MP0003303_peritoneal_inflammation1.64472141
26MP0001348_abnormal_lacrimal_gland1.64277515
27MP0003453_abnormal_keratinocyte_physiol1.63548022
28MP0003123_paternal_imprinting1.63490236
29MP0004947_skin_inflammation1.60674417
30MP0004233_abnormal_muscle_weight1.58358536
31MP0001849_ear_inflammation1.58183856
32MP0005409_darkened_coat_color1.55611128
33MP0004264_abnormal_extraembryonic_tissu1.54452071
34MP0004858_abnormal_nervous_system1.54329131
35MP0005387_immune_system_phenotype1.52214477
36MP0001790_abnormal_immune_system1.52214477
37MP0000685_abnormal_immune_system1.52196495
38MP0002420_abnormal_adaptive_immunity1.44814102
39MP0005666_abnormal_adipose_tissue1.44515834
40MP0002452_abnormal_antigen_presenting1.43717934
41MP0002166_altered_tumor_susceptibility1.43016180
42MP0001819_abnormal_immune_cell1.42270778
43MP0005499_abnormal_olfactory_system1.41471614
44MP0005394_taste/olfaction_phenotype1.41471614
45MP0000858_altered_metastatic_potential1.40408129
46MP0003693_abnormal_embryo_hatching1.39402100
47MP0000015_abnormal_ear_pigmentation1.38851346
48MP0009333_abnormal_splenocyte_physiolog1.38435689
49MP0001835_abnormal_antigen_presentation1.32078801
50MP0000716_abnormal_immune_system1.28558321
51MP0002249_abnormal_larynx_morphology1.28517269
52MP0004197_abnormal_fetal_growth/weight/1.27048162
53MP0010094_abnormal_chromosome_stability1.25474200
54MP0002089_abnormal_postnatal_growth/wei1.24811327
55MP0005671_abnormal_response_to1.24165839
56MP0001545_abnormal_hematopoietic_system1.23646237
57MP0005397_hematopoietic_system_phenotyp1.23646237
58MP0002723_abnormal_immune_serum1.23150934
59MP0005621_abnormal_cell_physiology1.22893243
60MP0008789_abnormal_olfactory_epithelium1.20556727
61MP0000490_abnormal_crypts_of1.20375249
62MP0000733_abnormal_muscle_development1.19411835
63MP0000350_abnormal_cell_proliferation1.18220567
64MP0004510_myositis1.16844299
65MP0000689_abnormal_spleen_morphology1.16207015
66MP0000678_abnormal_parathyroid_gland1.16143909
67MP0002722_abnormal_immune_system1.16017151
68MP0001346_abnormal_lacrimal_gland1.15017083
69MP0001915_intracranial_hemorrhage1.14974410
70MP0003111_abnormal_nucleus_morphology1.12787830
71MP0003436_decreased_susceptibility_to1.12178711
72MP0002429_abnormal_blood_cell1.11193585
73MP0002080_prenatal_lethality1.10746737
74MP0003191_abnormal_cellular_cholesterol1.10674016
75MP0005375_adipose_tissue_phenotype1.09135604
76MP0002796_impaired_skin_barrier1.07797899
77MP0002419_abnormal_innate_immunity1.06698296
78MP0004957_abnormal_blastocyst_morpholog1.06120392
79MP0008877_abnormal_DNA_methylation1.04056689
80MP0010630_abnormal_cardiac_muscle1.04011834
81MP0005623_abnormal_meninges_morphology1.01495174
82MP0005000_abnormal_immune_tolerance1.01455401
83MP0008569_lethality_at_weaning1.00833968
84MP0002925_abnormal_cardiovascular_devel0.98735879
85MP0003091_abnormal_cell_migration0.97795248
86MP0002006_tumorigenesis0.97175067
87MP0003077_abnormal_cell_cycle0.96929418
88MP0010234_abnormal_vibrissa_follicle0.94500043
89MP0002998_abnormal_bone_remodeling0.94104924
90MP0003221_abnormal_cardiomyocyte_apopto0.94066415
91MP0001697_abnormal_embryo_size0.93727553
92MP0003635_abnormal_synaptic_transmissio0.93506276
93MP0001873_stomach_inflammation0.92125451
94MP0009703_decreased_birth_body0.89553290
95MP0002092_abnormal_eye_morphology0.89116074
96MP0003984_embryonic_growth_retardation0.88599363
97MP0003828_pulmonary_edema0.88234051
98MP0002095_abnormal_skin_pigmentation0.88166811
99MP0010155_abnormal_intestine_physiology0.88160648
100MP0008007_abnormal_cellular_replicative0.88155198
101MP0000003_abnormal_adipose_tissue0.87981304
102MP0002086_abnormal_extraembryonic_tissu0.87926710
103MP0004381_abnormal_hair_follicle0.87599171
104MP0002088_abnormal_embryonic_growth/wei0.87288236
105MP0008770_decreased_survivor_rate0.87003294
106MP0000537_abnormal_urethra_morphology0.86270933
107MP0001851_eye_inflammation0.85918795
108MP0005501_abnormal_skin_physiology0.85908815
109MP0001853_heart_inflammation0.84578214
110MP0009931_abnormal_skin_appearance0.82912034
111MP0002084_abnormal_developmental_patter0.82568901
112MP0003943_abnormal_hepatobiliary_system0.82329666
113MP0003045_fibrosis0.82257019
114MP0003861_abnormal_nervous_system0.81353254
115MP0010307_abnormal_tumor_latency0.80361087
116MP0003183_abnormal_peptide_metabolism0.80260082
117MP0003935_abnormal_craniofacial_develop0.79737278
118MP0004185_abnormal_adipocyte_glucose0.78841262
119MP0000778_abnormal_nervous_system0.76502461
120MP0005380_embryogenesis_phenotype0.75517265
121MP0001672_abnormal_embryogenesis/_devel0.75517265
122MP0003890_abnormal_embryonic-extraembry0.75367955
123MP0005025_abnormal_response_to0.75226461
124MP0003566_abnormal_cell_adhesion0.74409803
125MP0001730_embryonic_growth_arrest0.73335167
126MP0002405_respiratory_system_inflammati0.73186865
127MP0002909_abnormal_adrenal_gland0.72564262
128MP0000313_abnormal_cell_death0.71953495
129MP0000371_diluted_coat_color0.71715634
130MP0002075_abnormal_coat/hair_pigmentati0.71149514
131MP0002933_joint_inflammation0.70379698
132MP0000465_gastrointestinal_hemorrhage0.70352064
133MP0000428_abnormal_craniofacial_morphol0.70069366
134MP0002085_abnormal_embryonic_tissue0.69694005
135MP0002081_perinatal_lethality0.68627433
136MP0001784_abnormal_fluid_regulation0.67954607
137MP0005464_abnormal_platelet_physiology0.67336831
138MP0003172_abnormal_lysosome_physiology0.66668477
139MP0003942_abnormal_urinary_system0.66295988
140MP0003115_abnormal_respiratory_system0.66260548
141MP0002019_abnormal_tumor_incidence0.65946899
142MP0009672_abnormal_birth_weight0.65543132

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.31255086
2Macroorchidism (HP:0000053)3.16402527
3Obstructive sleep apnea (HP:0002870)3.02836688
4Broad face (HP:0000283)2.93612391
5Hypoproteinemia (HP:0003075)2.87706699
6Volvulus (HP:0002580)2.78748799
7Syringomyelia (HP:0003396)2.61827887
8Spinal cord lesions (HP:0100561)2.61827887
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.60369955
10Short 4th metacarpal (HP:0010044)2.60369955
11Metaphyseal cupping (HP:0003021)2.58479153
12Eczematoid dermatitis (HP:0000976)2.44435542
13Asymmetry of the thorax (HP:0001555)2.43572268
14Flat acetabular roof (HP:0003180)2.41316518
15Hyperacusis (HP:0010780)2.38917373
16Recurrent viral infections (HP:0004429)2.36905158
17Shallow orbits (HP:0000586)2.32828427
18Long eyelashes (HP:0000527)2.31120244
19Vertebral arch anomaly (HP:0008438)2.30035977
20Ankyloglossia (HP:0010296)2.29599502
21Trigonocephaly (HP:0000243)2.27991178
22Persistence of primary teeth (HP:0006335)2.27680597
23Narrow palate (HP:0000189)2.26082205
24Supernumerary ribs (HP:0005815)2.25432965
25Mask-like facies (HP:0000298)2.24593905
26Cellulitis (HP:0100658)2.22547599
27Ependymoma (HP:0002888)2.20497314
28Dysmetric saccades (HP:0000641)2.19890201
29Abnormality of the distal phalanx of the thumb (HP:0009617)2.16523727
30Panhypogammaglobulinemia (HP:0003139)2.15394027
31Centrally nucleated skeletal muscle fibers (HP:0003687)2.14874255
32Pointed chin (HP:0000307)2.14539445
33Absent frontal sinuses (HP:0002688)2.14315197
34Annular pancreas (HP:0001734)2.10279157
35Increased IgE level (HP:0003212)2.08196860
36Heterotopia (HP:0002282)2.08076470
37Astrocytoma (HP:0009592)2.07979717
38Abnormality of the astrocytes (HP:0100707)2.07979717
39Prominent nose (HP:0000448)2.07750106
40Recurrent fungal infections (HP:0002841)2.07611397
41Exotropia (HP:0000577)2.05763465
42Agammaglobulinemia (HP:0004432)2.04811517
43Abnormality of the thoracic spine (HP:0100711)2.03443522
44Renal duplication (HP:0000075)2.01771371
45Papilledema (HP:0001085)2.00610078
46T lymphocytopenia (HP:0005403)2.00572978
47Tented upper lip vermilion (HP:0010804)1.98430074
48Increased connective tissue (HP:0009025)1.97827978
49Deep palmar crease (HP:0006191)1.97671317
50Verrucae (HP:0200043)1.96242104
51Papilloma (HP:0012740)1.96242104
52Urethral obstruction (HP:0000796)1.96143900
53Supernumerary bones of the axial skeleton (HP:0009144)1.95018755
54Obsessive-compulsive behavior (HP:0000722)1.94763279
55Lower limb asymmetry (HP:0100559)1.92702255
56Thin bony cortex (HP:0002753)1.92154664
57Distal lower limb amyotrophy (HP:0008944)1.92154632
58Basal cell carcinoma (HP:0002671)1.90927701
59Thick eyebrow (HP:0000574)1.90342946
60Protrusio acetabuli (HP:0003179)1.88879684
61Hemorrhage of the eye (HP:0011885)1.87456544
62Segmental peripheral demyelination/remyelination (HP:0003481)1.87140369
63Disproportionate tall stature (HP:0001519)1.85294733
64Acute lymphatic leukemia (HP:0006721)1.84775570
65Increased nuchal translucency (HP:0010880)1.84016076
66Achilles tendon contracture (HP:0001771)1.83960323
67Dislocated radial head (HP:0003083)1.83590886
68Mitral regurgitation (HP:0001653)1.83244116
69Bowel incontinence (HP:0002607)1.82562962
70Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.81986935
71Progressive external ophthalmoplegia (HP:0000590)1.81920782
72Abnormality of T cell number (HP:0011839)1.81070326
73Aqueductal stenosis (HP:0002410)1.78773419
74Thoracic kyphosis (HP:0002942)1.77630281
75Slow saccadic eye movements (HP:0000514)1.77472925
76Broad palm (HP:0001169)1.76968694
77Sparse lateral eyebrow (HP:0005338)1.75486562
78Deep philtrum (HP:0002002)1.74394498
79Deep venous thrombosis (HP:0002625)1.74193720
80Limited elbow extension (HP:0001377)1.74013995
81Midline defect of the nose (HP:0004122)1.74007329
82Abnormality of the radial head (HP:0003995)1.72781498
83Arnold-Chiari malformation (HP:0002308)1.71770832
84Abnormality of the 4th metacarpal (HP:0010012)1.71573511
85Viral hepatitis (HP:0006562)1.71536635
86Pseudobulbar signs (HP:0002200)1.71422572
87Elfin facies (HP:0004428)1.71121498
88Increased variability in muscle fiber diameter (HP:0003557)1.70392600
89Hypoplasia of the maxilla (HP:0000327)1.69826083
90Sacral dimple (HP:0000960)1.69226046
91Aneurysm (HP:0002617)1.69008223
92Abnormality of the calcaneus (HP:0008364)1.68530986
93Lip pit (HP:0100267)1.68126090
94Long palpebral fissure (HP:0000637)1.67397588
95Tapered finger (HP:0001182)1.67259398
96Neuronal loss in central nervous system (HP:0002529)1.67064820
97Chest pain (HP:0100749)1.67033701
98Abnormality of the intervertebral disk (HP:0005108)1.66902268
99Patellar dislocation (HP:0002999)1.66731931
100Abnormal large intestine physiology (HP:0012700)1.66602376
101Abnormality of the phalanges of the hallux (HP:0010057)1.64408510
102Abnormality of the Achilles tendon (HP:0005109)1.64395645
103Abnormality of homocysteine metabolism (HP:0010919)1.64369405
104Homocystinuria (HP:0002156)1.64369405
105Progressive muscle weakness (HP:0003323)1.64124776
106Back pain (HP:0003418)1.63527069
107Gastrointestinal inflammation (HP:0004386)1.63381295
108Thin ribs (HP:0000883)1.61986352
109Synophrys (HP:0000664)1.61622882
110Advanced eruption of teeth (HP:0006288)1.61593781
111Recurrent bronchitis (HP:0002837)1.61425446
112Vertebral compression fractures (HP:0002953)1.61342392
113Colitis (HP:0002583)1.60689928
114High pitched voice (HP:0001620)1.60347610
115Abnormality of skeletal muscle fiber size (HP:0012084)1.60340374
116Spinal muscular atrophy (HP:0007269)1.58785320
117Cerebral aneurysm (HP:0004944)1.58610489
118Upper limb amyotrophy (HP:0009129)1.58448996
119Distal upper limb amyotrophy (HP:0007149)1.58448996
120Increased density of long bones (HP:0006392)1.58258796
121Neoplasm of the oral cavity (HP:0100649)1.58083112
122Abnormal delayed hypersensitivity skin test (HP:0002963)1.57955779
123Inappropriate behavior (HP:0000719)1.57815334
124Ulnar bowing (HP:0003031)1.57805905
125Polygenic inheritance (HP:0010982)1.57190153
126Neoplasm of the heart (HP:0100544)1.56870294
127Flared metaphyses (HP:0003015)1.56052402
128Thyroiditis (HP:0100646)1.55161017
129Subacute progressive viral hepatitis (HP:0006572)1.55070440
130Cutis marmorata (HP:0000965)1.54695121
131Mitral valve prolapse (HP:0001634)1.54355038
132Abnormality of the salivary glands (HP:0010286)1.54273203
133Gastrointestinal stroma tumor (HP:0100723)1.54096706
134Hypercortisolism (HP:0001578)1.53922928
135Hypotelorism (HP:0000601)1.53904627
136Broad thumb (HP:0011304)1.53832605
137Abnormality of the columella (HP:0009929)1.53698615
138Skull defect (HP:0001362)1.53609730
139Hematochezia (HP:0002573)1.53573068
140Dilatation of the ascending aorta (HP:0005111)1.53456149
141Dysdiadochokinesis (HP:0002075)1.53426556
142Acute myeloid leukemia (HP:0004808)1.53383024
143Inflammation of the large intestine (HP:0002037)1.53306869
144Deviation of the thumb (HP:0009603)1.52583823
145Renovascular hypertension (HP:0100817)1.52106433
146Broad distal phalanx of finger (HP:0009836)1.51335105
147Biconcave vertebral bodies (HP:0004586)1.50781741
148Turricephaly (HP:0000262)1.50706111
149Spina bifida occulta (HP:0003298)1.50461882
150Skin tags (HP:0010609)1.49456714
151Precocious puberty (HP:0000826)1.49131358
152Abnormality of oral frenula (HP:0000190)1.48756199
153Overriding aorta (HP:0002623)1.48093299
154Osteomyelitis (HP:0002754)1.47782820
155Fatigue (HP:0012378)1.47743517
156Insomnia (HP:0100785)1.47498420
157Enlarged penis (HP:0000040)1.47069773
1582-3 toe syndactyly (HP:0004691)1.47005841
159Relative macrocephaly (HP:0004482)1.45976343
160Ectopic kidney (HP:0000086)1.45715425
161Abnormality of the humeroradial joint (HP:0100744)1.45655234
162Apathy (HP:0000741)1.45571395
163Glioma (HP:0009733)1.45270517
164Abnormality of the right ventricle (HP:0001707)1.44702753
165Aplasia/Hypoplasia of the sternum (HP:0006714)1.44623255
166Proximal placement of thumb (HP:0009623)1.44082406
167Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.43286068
168Abnormal vertebral ossification (HP:0100569)1.43146422
169Gingivitis (HP:0000230)1.42674713
170Recurrent abscess formation (HP:0002722)1.42478745

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BRD44.36175058
2MAP3K103.98521553
3SMG13.65047187
4CDK123.23230886
5EPHA33.15024654
6PRPF4B2.25495343
7EEF2K2.23097153
8SIK22.08484515
9MAP4K12.05268725
10RIPK41.81140640
11MAP3K131.79113494
12LATS11.78903238
13ERN11.76592508
14PDGFRA1.69928100
15CDC71.69206845
16IRAK31.58276332
17CAMKK21.45567557
18PTK61.41225046
19GRK61.39955373
20ACVR1B1.39638743
21KSR11.37716801
22MAP2K31.36615264
23KSR21.35472921
24CLK11.34717632
25PRKD21.34297257
26EPHB11.31846190
27TAOK21.26299802
28PKN21.23174310
29SIK31.21508101
30PASK1.20543807
31TRIB31.20045008
32PDGFRB1.18793719
33ALK1.16117749
34FGFR31.16101657
35NTRK21.15026406
36CSK1.10010627
37HCK1.08547143
38CAMK1G1.06871535
39TXK1.03310211
40ERBB31.01848454
41STK101.01262438
42TYK20.98910143
43CDK60.92832999
44BRSK20.92324515
45BTK0.91828342
46TYRO30.91555046
47CAMKK10.90854036
48WNK10.89295737
49ICK0.88833828
50BMX0.87199093
51TRPM70.84192044
52MAPK110.84058907
53ZAP700.83722702
54TTN0.83593231
55CDK70.82845851
56UHMK10.82357992
57CAMK1D0.81880165
58MAP3K70.81615355
59LATS20.78342130
60MAP3K10.78243300
61CSF1R0.78188657
62IRAK20.77306718
63RIPK10.76845581
64ITK0.76049196
65HIPK20.75957208
66ATR0.75883458
67RPS6KB20.75741005
68MTOR0.74618771
69JAK10.74573647
70CHEK10.74380293
71NEK20.74208069
72CDK90.74066092
73CDK40.74010079
74DAPK20.73347401
75PRKD10.71523976
76SYK0.69185035
77SGK30.68894278
78MAP3K140.68489119
79FGFR40.68382465
80MAP3K60.68059825
81TAOK10.67805730
82MAP3K80.66872340
83EPHA40.65947057
84JAK30.65371478
85FGFR20.65345232
86PRKCH0.65086490
87TGFBR10.64614179
88LCK0.63514654
89PTK20.63277117
90CDC42BPA0.63190564
91PDPK10.62304385
92MATK0.61225740
93RPS6KC10.59929228
94RPS6KL10.59929228
95MAP2K20.59343993
96SCYL20.56773249
97MKNK20.56328566
98MAP3K30.56186615
99STK110.56003893
100PRKD30.55905992
101CDK20.55189394
102YES10.54500733
103DAPK10.54306945
104FES0.54060507
105RET0.52869717
106BRSK10.52811780
107LYN0.52499813
108ATM0.51792145
109TESK20.51766826
110MAPK100.51479946
111SIK10.50914587
112IRAK40.50403216
113MARK20.49758548
114RPS6KA20.49756503
115CHUK0.48951900
116TBK10.47563473
117PAK40.47336611
118MELK0.47195889
119CSNK1A1L0.45945798
120MAPK80.45869819
121KIT0.45868962
122MAP3K90.45015629
123SGK20.44669277
124ERBB20.44653318
125GSK3B0.44269482
126MAPK120.44194493
127LRRK20.44048998
128TNK20.43603423
129MARK30.42896181
130MAPK140.42801977
131JAK20.42333575
132MAPK70.42214336
133DYRK1A0.41454899
134AKT10.40424052
135PDK10.40043073
136NME20.37517263
137FGR0.37360590
138RPS6KA10.36637544
139DMPK0.36538437
140RPS6KA60.34837755
141BLK0.34018994

Predicted pathways (KEGG)

RankGene SetZ-score
1B cell receptor signaling pathway_Homo sapiens_hsa046621.95609880
2Primary immunodeficiency_Homo sapiens_hsa053401.87914491
3Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.81855886
4Olfactory transduction_Homo sapiens_hsa047401.67422172
5Other glycan degradation_Homo sapiens_hsa005111.58566245
6Thyroid cancer_Homo sapiens_hsa052161.56873356
7T cell receptor signaling pathway_Homo sapiens_hsa046601.49759934
8Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.47099908
9Chronic myeloid leukemia_Homo sapiens_hsa052201.44287651
10Bladder cancer_Homo sapiens_hsa052191.44236390
11Central carbon metabolism in cancer_Homo sapiens_hsa052301.41966370
12Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.41402286
13Notch signaling pathway_Homo sapiens_hsa043301.41226538
14Non-small cell lung cancer_Homo sapiens_hsa052231.36593839
15* mRNA surveillance pathway_Homo sapiens_hsa030151.36593324
16Lysine degradation_Homo sapiens_hsa003101.36076633
17Long-term potentiation_Homo sapiens_hsa047201.35822137
18mTOR signaling pathway_Homo sapiens_hsa041501.32354574
19Colorectal cancer_Homo sapiens_hsa052101.32079448
20Osteoclast differentiation_Homo sapiens_hsa043801.23665017
21Endometrial cancer_Homo sapiens_hsa052131.23642691
22Type II diabetes mellitus_Homo sapiens_hsa049301.23434557
23NF-kappa B signaling pathway_Homo sapiens_hsa040641.22062750
24Chemokine signaling pathway_Homo sapiens_hsa040621.21519086
25Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.18122493
26Neurotrophin signaling pathway_Homo sapiens_hsa047221.17769904
27Hepatitis C_Homo sapiens_hsa051601.16866811
28Glutamatergic synapse_Homo sapiens_hsa047241.16428986
29Transcriptional misregulation in cancer_Homo sapiens_hsa052021.15998455
30Glioma_Homo sapiens_hsa052141.15189885
31Prion diseases_Homo sapiens_hsa050201.14424363
32Pancreatic cancer_Homo sapiens_hsa052121.13844071
33Acute myeloid leukemia_Homo sapiens_hsa052211.12831991
34MicroRNAs in cancer_Homo sapiens_hsa052061.11289131
35Adherens junction_Homo sapiens_hsa045201.09031686
36Measles_Homo sapiens_hsa051621.08734513
37Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.05509627
38Thyroid hormone signaling pathway_Homo sapiens_hsa049191.03840143
39VEGF signaling pathway_Homo sapiens_hsa043701.03458997
40Leishmaniasis_Homo sapiens_hsa051401.00949633
41Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.00390403
42Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.00287406
43Small cell lung cancer_Homo sapiens_hsa052220.99945210
44Inositol phosphate metabolism_Homo sapiens_hsa005620.99864021
45Herpes simplex infection_Homo sapiens_hsa051680.99446251
46Aldosterone synthesis and secretion_Homo sapiens_hsa049250.98855574
47DNA replication_Homo sapiens_hsa030300.98736751
48Phosphatidylinositol signaling system_Homo sapiens_hsa040700.98353046
49Amphetamine addiction_Homo sapiens_hsa050310.97810375
50ErbB signaling pathway_Homo sapiens_hsa040120.97742491
51Hepatitis B_Homo sapiens_hsa051610.96943417
52Morphine addiction_Homo sapiens_hsa050320.96114767
53MAPK signaling pathway_Homo sapiens_hsa040100.96094581
54Spliceosome_Homo sapiens_hsa030400.93961261
55Cell cycle_Homo sapiens_hsa041100.93884146
56Viral myocarditis_Homo sapiens_hsa054160.93248569
57Toxoplasmosis_Homo sapiens_hsa051450.92910994
58Pentose phosphate pathway_Homo sapiens_hsa000300.92546613
59Proteoglycans in cancer_Homo sapiens_hsa052050.92312377
60Axon guidance_Homo sapiens_hsa043600.90851283
61HTLV-I infection_Homo sapiens_hsa051660.90716229
62Oxytocin signaling pathway_Homo sapiens_hsa049210.89401295
63Choline metabolism in cancer_Homo sapiens_hsa052310.88641966
64Circadian entrainment_Homo sapiens_hsa047130.86032283
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.85336448
66Longevity regulating pathway - mammal_Homo sapiens_hsa042110.84917304
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84577521
68Phospholipase D signaling pathway_Homo sapiens_hsa040720.84390342
69Epstein-Barr virus infection_Homo sapiens_hsa051690.82866233
70Renin secretion_Homo sapiens_hsa049240.82648634
71Cholinergic synapse_Homo sapiens_hsa047250.82161226
72Dopaminergic synapse_Homo sapiens_hsa047280.81801147
73Prostate cancer_Homo sapiens_hsa052150.81473175
74Wnt signaling pathway_Homo sapiens_hsa043100.81128309
75Platelet activation_Homo sapiens_hsa046110.80740185
76Antigen processing and presentation_Homo sapiens_hsa046120.80197076
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79799438
78FoxO signaling pathway_Homo sapiens_hsa040680.79668465
79Hematopoietic cell lineage_Homo sapiens_hsa046400.78561596
80Dorso-ventral axis formation_Homo sapiens_hsa043200.76948376
81Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.76384815
82Adipocytokine signaling pathway_Homo sapiens_hsa049200.76307225
83Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76301504
84AMPK signaling pathway_Homo sapiens_hsa041520.75958491
85Estrogen signaling pathway_Homo sapiens_hsa049150.75727401
86RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75359047
87HIF-1 signaling pathway_Homo sapiens_hsa040660.75296340
88Focal adhesion_Homo sapiens_hsa045100.74263524
89Toll-like receptor signaling pathway_Homo sapiens_hsa046200.74166962
90Influenza A_Homo sapiens_hsa051640.73813128
91Rap1 signaling pathway_Homo sapiens_hsa040150.73256933
92cGMP-PKG signaling pathway_Homo sapiens_hsa040220.73178246
93Endocytosis_Homo sapiens_hsa041440.72540100
94Shigellosis_Homo sapiens_hsa051310.72222113
95Amoebiasis_Homo sapiens_hsa051460.71749912
96Viral carcinogenesis_Homo sapiens_hsa052030.71543787
97Tuberculosis_Homo sapiens_hsa051520.70154883
98Sphingolipid signaling pathway_Homo sapiens_hsa040710.70152296
99Insulin resistance_Homo sapiens_hsa049310.69689488
100Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.69188434
101TNF signaling pathway_Homo sapiens_hsa046680.69090893
102NOD-like receptor signaling pathway_Homo sapiens_hsa046210.68799515
103GnRH signaling pathway_Homo sapiens_hsa049120.68173058
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.67734149
105Pathways in cancer_Homo sapiens_hsa052000.66431535
106Cyanoamino acid metabolism_Homo sapiens_hsa004600.66197489
107Fructose and mannose metabolism_Homo sapiens_hsa000510.66068524
108Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.65396763
109Biosynthesis of amino acids_Homo sapiens_hsa012300.65387719
110Insulin signaling pathway_Homo sapiens_hsa049100.63969826
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.63763767
112Prolactin signaling pathway_Homo sapiens_hsa049170.63384919
113Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.62434057
114Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.62285215
115Jak-STAT signaling pathway_Homo sapiens_hsa046300.62162217
116Renal cell carcinoma_Homo sapiens_hsa052110.62040825
117Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61962652
118Gastric acid secretion_Homo sapiens_hsa049710.60240942
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.59716522
120Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59171731
121Long-term depression_Homo sapiens_hsa047300.59124726
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.58900317
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58625507
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.58597858
125Cocaine addiction_Homo sapiens_hsa050300.58147094
126Basal cell carcinoma_Homo sapiens_hsa052170.58088491
127Apoptosis_Homo sapiens_hsa042100.58002593
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.54193920
129Salmonella infection_Homo sapiens_hsa051320.48771386

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