CPT1A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)6.89156180
2L-phenylalanine catabolic process (GO:0006559)6.89156180
3erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)6.64094717
4L-phenylalanine metabolic process (GO:0006558)6.64094717
5aromatic amino acid family catabolic process (GO:0009074)6.22751066
6triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.83894474
7glyoxylate metabolic process (GO:0046487)5.69135561
8alpha-linolenic acid metabolic process (GO:0036109)5.68213695
9tryptophan catabolic process (GO:0006569)5.61583186
10indole-containing compound catabolic process (GO:0042436)5.61583186
11indolalkylamine catabolic process (GO:0046218)5.61583186
12kynurenine metabolic process (GO:0070189)5.49259358
13bile acid biosynthetic process (GO:0006699)5.41785280
14tryptophan metabolic process (GO:0006568)5.32711832
15cysteine metabolic process (GO:0006534)5.32081291
16sulfur amino acid catabolic process (GO:0000098)5.25729074
17urea metabolic process (GO:0019627)5.22482461
18urea cycle (GO:0000050)5.22482461
19peptidyl-glutamic acid carboxylation (GO:0017187)5.13292906
20protein carboxylation (GO:0018214)5.13292906
21fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.12260267
22negative regulation of fibrinolysis (GO:0051918)5.03484786
23high-density lipoprotein particle remodeling (GO:0034375)5.01538393
24lysine catabolic process (GO:0006554)4.94576198
25lysine metabolic process (GO:0006553)4.94576198
26complement activation, alternative pathway (GO:0006957)4.86991440
27serine family amino acid catabolic process (GO:0009071)4.82523604
28regulation of protein activation cascade (GO:2000257)4.81538840
29homocysteine metabolic process (GO:0050667)4.80715983
30nitrogen cycle metabolic process (GO:0071941)4.78714784
31regulation of fibrinolysis (GO:0051917)4.74357397
32bile acid metabolic process (GO:0008206)4.65979761
33* amino-acid betaine metabolic process (GO:0006577)4.54903093
34reverse cholesterol transport (GO:0043691)4.54690731
35regulation of complement activation (GO:0030449)4.51793056
36regulation of triglyceride catabolic process (GO:0010896)4.51000679
37aromatic amino acid family metabolic process (GO:0009072)4.50026973
38regulation of cholesterol esterification (GO:0010872)4.44208493
39plasma lipoprotein particle remodeling (GO:0034369)4.39306971
40protein-lipid complex remodeling (GO:0034368)4.39306971
41macromolecular complex remodeling (GO:0034367)4.39306971
42negative regulation of cholesterol transport (GO:0032375)4.34641547
43negative regulation of sterol transport (GO:0032372)4.34641547
44tyrosine metabolic process (GO:0006570)4.33983166
45phospholipid efflux (GO:0033700)4.32998240
46alpha-amino acid catabolic process (GO:1901606)4.31115892
47acylglycerol homeostasis (GO:0055090)4.22491353
48triglyceride homeostasis (GO:0070328)4.22491353
49cellular ketone body metabolic process (GO:0046950)4.17556122
50drug catabolic process (GO:0042737)4.12801555
51cellular glucuronidation (GO:0052695)4.11895287
52plasma lipoprotein particle clearance (GO:0034381)4.11890136
53ethanol oxidation (GO:0006069)4.04695241
54cellular amino acid catabolic process (GO:0009063)4.03171202
55bile acid and bile salt transport (GO:0015721)4.02640573
56cellular modified amino acid catabolic process (GO:0042219)4.01925828
57glycine metabolic process (GO:0006544)3.98951317
58serine family amino acid metabolic process (GO:0009069)3.97509642
59drug transmembrane transport (GO:0006855)3.96359932
60negative regulation of erythrocyte differentiation (GO:0045647)3.96020137
61benzene-containing compound metabolic process (GO:0042537)3.94707653
62glutamate metabolic process (GO:0006536)3.94526244
63regulation of cholesterol homeostasis (GO:2000188)3.93931734
64indolalkylamine metabolic process (GO:0006586)3.93646732
65cholesterol efflux (GO:0033344)3.88224980
66urate metabolic process (GO:0046415)3.86525548
67phospholipid homeostasis (GO:0055091)3.85337804
68short-chain fatty acid metabolic process (GO:0046459)3.79673259
69coenzyme catabolic process (GO:0009109)3.78704043
70plasma lipoprotein particle assembly (GO:0034377)3.78551886
71dicarboxylic acid biosynthetic process (GO:0043650)3.77092327
72cellular biogenic amine catabolic process (GO:0042402)3.76578732
73amine catabolic process (GO:0009310)3.76578732
74fibrinolysis (GO:0042730)3.71957217
75glucuronate metabolic process (GO:0019585)3.70262291
76uronic acid metabolic process (GO:0006063)3.70262291
77low-density lipoprotein particle remodeling (GO:0034374)3.69292374
78serine family amino acid biosynthetic process (GO:0009070)3.68509750
79imidazole-containing compound metabolic process (GO:0052803)3.68492996
80aldehyde catabolic process (GO:0046185)3.63667044
812-oxoglutarate metabolic process (GO:0006103)3.63008757
82exogenous drug catabolic process (GO:0042738)3.62380472
83arginine metabolic process (GO:0006525)3.62367856
84* carboxylic acid catabolic process (GO:0046395)3.60791678
85* organic acid catabolic process (GO:0016054)3.60791678
86cholesterol homeostasis (GO:0042632)3.60703332
87ketone body metabolic process (GO:1902224)3.59907027
88mannose metabolic process (GO:0006013)3.58360020
89flavonoid metabolic process (GO:0009812)3.56789988
90sterol homeostasis (GO:0055092)3.56435768
91acetyl-CoA metabolic process (GO:0006084)3.54994574
92regulation of bile acid biosynthetic process (GO:0070857)3.54474745
93* fatty acid beta-oxidation (GO:0006635)3.53397959
94positive regulation of triglyceride lipase activity (GO:0061365)3.53252284
95positive regulation of lipoprotein lipase activity (GO:0051006)3.53252284
96* fatty acid oxidation (GO:0019395)3.52703416
97epoxygenase P450 pathway (GO:0019373)3.48450756
98* lipid oxidation (GO:0034440)3.46814280
99valine metabolic process (GO:0006573)3.46810716
100desmosome organization (GO:0002934)3.46539767
101aspartate family amino acid catabolic process (GO:0009068)3.46046734
102protein-lipid complex assembly (GO:0065005)3.44961217
103* monocarboxylic acid catabolic process (GO:0072329)3.44948462
104blood coagulation, intrinsic pathway (GO:0007597)3.44869783
105Golgi transport vesicle coating (GO:0048200)3.44831135
106COPI coating of Golgi vesicle (GO:0048205)3.44831135
107negative regulation of fatty acid transport (GO:2000192)3.33198645
108positive regulation of Cdc42 GTPase activity (GO:0043089)3.20003120
109positive regulation of keratinocyte differentiation (GO:0045618)3.11390365
110angiotensin maturation (GO:0002003)3.02216200
111iron ion import (GO:0097286)3.00902126
112hepatocyte apoptotic process (GO:0097284)2.85990717
113embryonic process involved in female pregnancy (GO:0060136)2.83086657
114NADH metabolic process (GO:0006734)2.81231181
115proline biosynthetic process (GO:0006561)2.80634391
116negative regulation of cell size (GO:0045792)2.76335525
117regulation of integrin activation (GO:0033623)2.73905657
118hormone catabolic process (GO:0042447)2.73686895
119branching involved in mammary gland duct morphogenesis (GO:0060444)2.67515468
120pinocytosis (GO:0006907)2.67273425
121epithelial cell-cell adhesion (GO:0090136)2.63768463
122glycosphingolipid catabolic process (GO:0046479)2.63545201
123intestinal absorption (GO:0050892)2.61585015
124definitive hemopoiesis (GO:0060216)2.55096199
125antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.54930298
126antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.54190833
127ethanol metabolic process (GO:0006067)2.50696835
128regulation of vitamin metabolic process (GO:0030656)2.48411863
129response to thyroid hormone (GO:0097066)2.48198523
130protein localization to endosome (GO:0036010)2.45337886
131omega-hydroxylase P450 pathway (GO:0097267)2.45073326
132antigen processing and presentation of endogenous antigen (GO:0019883)2.41995670
133glycolipid catabolic process (GO:0019377)2.40425304
134regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.40157747
135intestinal epithelial cell development (GO:0060576)2.39735200
136amyloid precursor protein catabolic process (GO:0042987)2.38637833
137phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.38363730
138epithelial cell differentiation involved in prostate gland development (GO:0060742)2.36662086
139peptide catabolic process (GO:0043171)2.36284706
140very-low-density lipoprotein particle assembly (GO:0034379)2.35462200
141regulation of histone H3-K27 methylation (GO:0061085)2.35019147
142regulation of glucose import in response to insulin stimulus (GO:2001273)2.34299384
143glucose 6-phosphate metabolic process (GO:0051156)2.34298048
144regulation of water loss via skin (GO:0033561)2.34040711
145renal filtration (GO:0097205)2.32741192
146insulin-like growth factor receptor signaling pathway (GO:0048009)2.32511231
147negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.31094544
148glucose catabolic process (GO:0006007)2.29648760
149glutamine family amino acid biosynthetic process (GO:0009084)2.28726200
150regulation of leukocyte degranulation (GO:0043300)2.28507913
151glomerular filtration (GO:0003094)2.27314429
152positive regulation of epidermal cell differentiation (GO:0045606)2.27224358
153pentose-phosphate shunt (GO:0006098)2.25757750
154retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.24091258
155maternal placenta development (GO:0001893)2.22520334
156response to food (GO:0032094)2.22175105
157sphingomyelin metabolic process (GO:0006684)2.21012076
158activation of Rac GTPase activity (GO:0032863)2.20887206
159proline metabolic process (GO:0006560)2.20583715
160regulation of extracellular matrix disassembly (GO:0010715)2.18407234
161response to peptidoglycan (GO:0032494)2.17797129
162positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.17278792
163regulation of gamma-delta T cell differentiation (GO:0045586)2.16457581
164hyaluronan catabolic process (GO:0030214)2.16384696
165multicellular organismal water homeostasis (GO:0050891)2.14543345
166positive regulation of histone deacetylation (GO:0031065)2.13926414
167bundle of His cell to Purkinje myocyte communication (GO:0086069)2.13601981
168negative regulation of viral release from host cell (GO:1902187)2.13018400
169auditory receptor cell differentiation (GO:0042491)2.11778186
170positive regulation of extracellular matrix organization (GO:1903055)2.11234041
171negative regulation of interleukin-8 production (GO:0032717)2.11018991
172regulation of cholesterol metabolic process (GO:0090181)2.09699343
173striated muscle atrophy (GO:0014891)2.08771396
174citrulline biosynthetic process (GO:0019240)2.08628288
175COPII vesicle coating (GO:0048208)2.08247242
176response to laminar fluid shear stress (GO:0034616)2.06715676
177oxaloacetate metabolic process (GO:0006107)2.06532963
178cellular response to thyroid hormone stimulus (GO:0097067)2.05722878
179regulation of keratinocyte differentiation (GO:0045616)2.05702896
180response to water (GO:0009415)2.05229224
181regulation of viral release from host cell (GO:1902186)2.04379949
182positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.03812453
183positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.02490683
184complement activation, classical pathway (GO:0006958)2.02459951
185trophectodermal cell differentiation (GO:0001829)2.02287825
186citrulline metabolic process (GO:0000052)2.01963403

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* RXR_22158963_ChIP-Seq_LIVER_Mouse7.63472552
2* PPARA_22158963_ChIP-Seq_LIVER_Mouse6.66591961
3* LXR_22158963_ChIP-Seq_LIVER_Mouse5.98963199
4EGR1_23403033_ChIP-Seq_LIVER_Mouse5.81260268
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.99402290
6FOXO1_23066095_ChIP-Seq_LIVER_Mouse4.67091857
7CEBPA_23403033_ChIP-Seq_LIVER_Mouse4.25086526
8NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.66539966
9CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.29831113
10* VDR_21846776_ChIP-Seq_THP-1_Human2.40882527
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.35391693
12TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.25916467
13MYC_22102868_ChIP-Seq_BL_Human2.18099350
14CLOCK_20551151_ChIP-Seq_293T_Human2.17973677
15* ESR1_17901129_ChIP-ChIP_LIVER_Mouse10.6611386
16HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.98316159
17TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.95502912
18* TCF7_22412390_ChIP-Seq_EML_Mouse1.94907005
19VDR_24763502_ChIP-Seq_THP-1_Human1.94128370
20* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.91634178
21* TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.91580711
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.84012674
23GATA1_22025678_ChIP-Seq_K562_Human1.79862278
24* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.73055089
25MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.68185279
26* RUNX1_27514584_Chip-Seq_MCF-7_Human1.65317830
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63520461
28* FOXA2_19822575_ChIP-Seq_HepG2_Human1.63270079
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.56161259
30IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.51867180
31RUNX1_22412390_ChIP-Seq_EML_Mouse1.51824791
32STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.51210607
33RARG_19884340_ChIP-ChIP_MEFs_Mouse1.46183499
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.42350499
35* KDM2B_26808549_Chip-Seq_DND41_Human1.42332006
36STAT6_21828071_ChIP-Seq_BEAS2B_Human1.37902371
37* HNF4A_19822575_ChIP-Seq_HepG2_Human1.37268822
38GATA1_22383799_ChIP-Seq_G1ME_Mouse1.37141464
39MAF_26560356_Chip-Seq_TH1_Human1.34635786
40* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.30888670
41* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.25974788
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.24634273
43* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.23813685
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.23317789
45E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.22651855
46RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.21354211
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.20353137
48GATA2_22383799_ChIP-Seq_G1ME_Mouse1.17400892
49* UTX_26944678_Chip-Seq_JUKART_Human1.15695894
50SPI1_23127762_ChIP-Seq_K562_Human1.15451948
51Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.15320976
52ESR2_21235772_ChIP-Seq_MCF-7_Human1.14075263
53HIF1A_21447827_ChIP-Seq_MCF-7_Human1.13222532
54GATA4_25053715_ChIP-Seq_YYC3_Human1.12796852
55BP1_19119308_ChIP-ChIP_Hs578T_Human1.11838847
56* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.10713537
57CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.09006116
58SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.08906081
59SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.08906081
60ESR1_21235772_ChIP-Seq_MCF-7_Human1.08359500
61ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08090290
62* CTCF_27219007_Chip-Seq_ERYTHROID_Human1.07385399
63* CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06539491
64* NCOR1_26117541_ChIP-Seq_K562_Human1.06463566
65NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.05315800
66SPI1_23547873_ChIP-Seq_NB4_Human1.05260595
67ZNF263_19887448_ChIP-Seq_K562_Human1.04704188
68STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04589552
69CREB1_26743006_Chip-Seq_LNCaP_Human1.04500468
70* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.04267246
71STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03535098
72RXRA_24833708_ChIP-Seq_LIVER_Mouse1.02396996
73ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.01152122
74TP63_17297297_ChIP-ChIP_HaCaT_Human1.00214344
75PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.99093808
76* P68_20966046_ChIP-Seq_HELA_Human0.98873015
77SOX9_24532713_ChIP-Seq_HFSC_Mouse0.98521897
78* TET1_21451524_ChIP-Seq_MESCs_Mouse0.98334152
79FOXO3_23340844_ChIP-Seq_DLD1_Human0.93728408
80LXR_22292898_ChIP-Seq_THP-1_Human0.93723307
81PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.91187732
82HTT_18923047_ChIP-ChIP_STHdh_Human0.89047405
83PPAR_26484153_Chip-Seq_NCI-H1993_Human0.88925661
84* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.86853155
85BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.86562231
86STAT3_1855785_ChIP-Seq_MESCs_Mouse0.86397772
87SALL4_18804426_ChIP-ChIP_XEN_Mouse0.85225928
88CDX2_20551321_ChIP-Seq_CACO-2_Human0.84277156
89GATA6_25053715_ChIP-Seq_YYC3_Human0.82682123
90SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.81401138
91* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.80153422
92GATA1_19941826_ChIP-Seq_K562_Human0.78708790
93ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.78687379
94* BRD4_27068464_Chip-Seq_AML-cells_Mouse0.78093698
95GATA2_19941826_ChIP-Seq_K562_Human0.76624434
96* AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.76473055
97* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.74441126
98IRF8_27001747_Chip-Seq_BMDM_Mouse0.74055983
99FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.73551760
100* GATA1_19941827_ChIP-Seq_MEL_Mouse0.72930230
101* RACK7_27058665_Chip-Seq_MCF-7_Human0.72069373
102* SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.70086915
103MYB_21317192_ChIP-Seq_ERMYB_Mouse0.67742304
104AUTS2_25519132_ChIP-Seq_293T-REX_Human0.67427657
105SCL_19346495_ChIP-Seq_HPC-7_Human0.67382909
106* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.67242032
107GATA2_21666600_ChIP-Seq_HMVEC_Human0.66624121
108SOX2_20726797_ChIP-Seq_SW620_Human0.65533378
109TRIM28_21343339_ChIP-Seq_HEK293_Human0.64461479
110ESR1_20079471_ChIP-ChIP_T-47D_Human0.62920683
111FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.62902491
112RARA_24833708_ChIP-Seq_LIVER_Mouse0.62845570
113SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.62184909
114PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.61659324
115EGR1_19032775_ChIP-ChIP_M12_Human0.60575794
116* ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.60061279
117CEBPB_22108803_ChIP-Seq_LS180_Human0.58343183
118RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.58119387
119GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.57811774
120* TBX20_22328084_ChIP-Seq_HEART_Mouse0.57297936
121* TBX20_22080862_ChIP-Seq_HEART_Mouse0.57297936
122FOXA1_25552417_ChIP-Seq_VCAP_Human0.57266424
123* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.56908623
124* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.56908623
125* BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.56346550
126FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.56054267
127* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.56033033
128* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.55640291
129* ELK3_25401928_ChIP-Seq_HUVEC_Human0.54812311
130RARB_24833708_ChIP-Seq_LIVER_Mouse0.54413983
131FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.54082426
132* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.53645424
133* ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.53517586
134GATA3_24758297_ChIP-Seq_MCF-7_Human0.52869145
135* PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.52828386
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.52812965
137RAD21_21589869_ChIP-Seq_MESCs_Mouse0.51657836
138ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.50337625
139P63_26484246_Chip-Seq_KERATINOCYTES_Human0.48891446
140ATF3_27146783_Chip-Seq_COLON_Human0.48829989

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system7.49158971
2MP0005360_urolithiasis7.15987304
3MP0005085_abnormal_gallbladder_physiolo5.68271801
4MP0005365_abnormal_bile_salt5.62022454
5MP0008875_abnormal_xenobiotic_pharmacok4.83459042
6MP0003252_abnormal_bile_duct3.73832280
7MP0003806_abnormal_nucleotide_metabolis3.47050055
8MP0010329_abnormal_lipoprotein_level3.33444545
9MP0009840_abnormal_foam_cell3.20149501
10MP0005332_abnormal_amino_acid2.82751080
11MP0003195_calcinosis2.74752487
12MP0003191_abnormal_cellular_cholesterol2.63396646
13MP0005083_abnormal_biliary_tract2.62600697
14MP0001666_abnormal_nutrient_absorption2.48248334
15MP0004019_abnormal_vitamin_homeostasis2.37999777
16MP0002138_abnormal_hepatobiliary_system2.20553073
17MP0005409_darkened_coat_color2.19696243
18MP0003183_abnormal_peptide_metabolism2.11774355
19MP0000609_abnormal_liver_physiology2.10985832
20* MP0002118_abnormal_lipid_homeostasis1.96137936
21MP0002396_abnormal_hematopoietic_system1.91573920
22MP0002877_abnormal_melanocyte_morpholog1.90425109
23MP0001873_stomach_inflammation1.90082679
24MP0005319_abnormal_enzyme/_coenzyme1.85904569
25MP0002009_preneoplasia1.84230738
26MP0010352_gastrointestinal_tract_polyps1.73133542
27MP0005076_abnormal_cell_differentiation1.68376729
28MP0009643_abnormal_urine_homeostasis1.64621271
29MP0003705_abnormal_hypodermis_morpholog1.61666767
30MP0003868_abnormal_feces_composition1.61471272
31MP0003011_delayed_dark_adaptation1.55701856
32MP0003866_abnormal_defecation1.52937553
33MP0005584_abnormal_enzyme/coenzyme_acti1.51190805
34MP0001764_abnormal_homeostasis1.51039234
35MP0003172_abnormal_lysosome_physiology1.38272626
36MP0003186_abnormal_redox_activity1.33338281
37MP0001835_abnormal_antigen_presentation1.29191936
38MP0003763_abnormal_thymus_physiology1.24742196
39MP0004185_abnormal_adipocyte_glucose1.24047403
40MP0002098_abnormal_vibrissa_morphology1.22946660
41MP0000598_abnormal_liver_morphology1.22883100
42MP0005501_abnormal_skin_physiology1.22121221
43MP0010368_abnormal_lymphatic_system1.22038399
44MP0003303_peritoneal_inflammation1.21836956
45MP0002254_reproductive_system_inflammat1.21469666
46MP0002006_tumorigenesis1.19279279
47MP0000858_altered_metastatic_potential1.18570624
48MP0003656_abnormal_erythrocyte_physiolo1.17500780
49MP0005025_abnormal_response_to1.17410800
50MP0005451_abnormal_body_composition1.16740644
51MP0009764_decreased_sensitivity_to1.14680632
52MP0008438_abnormal_cutaneous_collagen1.13299223
53MP0001849_ear_inflammation1.09677702
54MP0003300_gastrointestinal_ulcer1.09189235
55MP0005636_abnormal_mineral_homeostasis1.08782595
56MP0004858_abnormal_nervous_system1.06935448
57MP0005670_abnormal_white_adipose1.05248907
58MP0001533_abnormal_skeleton_physiology1.04943477
59MP0010678_abnormal_skin_adnexa1.04274417
60MP0009763_increased_sensitivity_to1.03305992
61MP0001881_abnormal_mammary_gland1.03002099
62MP0004808_abnormal_hematopoietic_stem1.02871506
63MP0008469_abnormal_protein_level1.02612268
64MP0005647_abnormal_sex_gland1.02459035
65MP0000465_gastrointestinal_hemorrhage1.02250136
66MP0003828_pulmonary_edema1.00439747
67MP0001216_abnormal_epidermal_layer0.99350044
68MP0001756_abnormal_urination0.97922087
69MP0000604_amyloidosis0.97561410
70MP0008260_abnormal_autophagy0.97560060
71MP0000685_abnormal_immune_system0.97543696
72MP0003091_abnormal_cell_migration0.97357828
73MP0000627_abnormal_mammary_gland0.97180443
74MP0009780_abnormal_chondrocyte_physiolo0.97050274
75MP0000490_abnormal_crypts_of0.96113901
76MP0003045_fibrosis0.93197723
77MP0004233_abnormal_muscle_weight0.92495801
78MP0005397_hematopoietic_system_phenotyp0.91505037
79MP0001545_abnormal_hematopoietic_system0.91505037
80MP0000477_abnormal_intestine_morphology0.90515328
81MP0009278_abnormal_bone_marrow0.88756496
82MP0002136_abnormal_kidney_physiology0.88093464
83MP0009697_abnormal_copulation0.87616642
84MP0009931_abnormal_skin_appearance0.87393025
85* MP0009642_abnormal_blood_homeostasis0.87172709
86MP0002998_abnormal_bone_remodeling0.85734367
87MP0004130_abnormal_muscle_cell0.85547674
88MP0001664_abnormal_digestion0.85374542
89MP0001851_eye_inflammation0.85161874
90MP0000467_abnormal_esophagus_morphology0.84995202
91MP0009785_altered_susceptibility_to0.84765156
92MP0005000_abnormal_immune_tolerance0.84627680
93MP0009333_abnormal_splenocyte_physiolog0.82820307
94MP0005464_abnormal_platelet_physiology0.82430726
95MP0002896_abnormal_bone_mineralization0.81840093
96MP0005165_increased_susceptibility_to0.81598580
97MP0005058_abnormal_lysosome_morphology0.81041603
98MP0002148_abnormal_hypersensitivity_rea0.80515589
99MP0003436_decreased_susceptibility_to0.78871615
100MP0005220_abnormal_exocrine_pancreas0.77963265
101MP0005408_hypopigmentation0.77058164
102MP0005375_adipose_tissue_phenotype0.74649291
103MP0001661_extended_life_span0.73655515
104MP0002971_abnormal_brown_adipose0.72717452
105MP0009765_abnormal_xenobiotic_induced0.71779135
106MP0005376_homeostasis/metabolism_phenot0.70994563
107MP0003724_increased_susceptibility_to0.70656807
108* MP0002078_abnormal_glucose_homeostasis0.68051515
109MP0010234_abnormal_vibrissa_follicle0.67914516
110MP0005334_abnormal_fat_pad0.66780935
111MP0002928_abnormal_bile_duct0.66619159
112MP0005666_abnormal_adipose_tissue0.65626740
113MP0006036_abnormal_mitochondrial_physio0.64281108
114MP0005084_abnormal_gallbladder_morpholo0.63082931
115MP0003638_abnormal_response/metabolism_0.63019920
116MP0003690_abnormal_glial_cell0.62299784
117MP0009384_cardiac_valve_regurgitation0.59878448
118MP0004043_abnormal_pH_regulation0.59402079
119MP0001853_heart_inflammation0.58619896
120MP0001845_abnormal_inflammatory_respons0.55453553
121MP0002796_impaired_skin_barrier0.55152217
122MP0001765_abnormal_ion_homeostasis0.54966585
123MP0005535_abnormal_body_temperature0.54539320
124MP0003075_altered_response_to0.53309592
125MP0005023_abnormal_wound_healing0.52825144
126MP0004264_abnormal_extraembryonic_tissu0.51703433
127MP0005266_abnormal_metabolism0.50579848
128MP0005166_decreased_susceptibility_to0.50009924
129MP0004782_abnormal_surfactant_physiolog0.49194371
130MP0004947_skin_inflammation0.48994358
131MP0002060_abnormal_skin_morphology0.47191458
132MP0002135_abnormal_kidney_morphology0.46206563
133MP0009115_abnormal_fat_cell0.46176328
134MP0002876_abnormal_thyroid_physiology0.45989626
135MP0008873_increased_physiological_sensi0.44994119
136MP0000249_abnormal_blood_vessel0.44749098
137MP0009053_abnormal_anal_canal0.43964460
138MP0000639_abnormal_adrenal_gland0.43910097
139MP0003566_abnormal_cell_adhesion0.42954410
140MP0005167_abnormal_blood-brain_barrier0.42734777
141MP0005448_abnormal_energy_balance0.41714903
142MP0000230_abnormal_systemic_arterial0.41632999
143MP0003329_amyloid_beta_deposits0.41266601
144* MP0002168_other_aberrant_phenotype0.40809105
145MP0006082_CNS_inflammation0.40648721
146* MP0005395_other_phenotype0.40110470
147MP0003453_abnormal_keratinocyte_physiol0.39657550
148MP0002166_altered_tumor_susceptibility0.37813492
149MP0010155_abnormal_intestine_physiology0.37631639
150MP0002419_abnormal_innate_immunity0.37267058
151MP0001915_intracranial_hemorrhage0.36332748
152MP0008874_decreased_physiological_sensi0.36084732
153MP0003953_abnormal_hormone_level0.35997225

Predicted human phenotypes

RankGene SetZ-score
1Deep venous thrombosis (HP:0002625)6.66223896
2Abnormality of aromatic amino acid family metabolism (HP:0004338)6.51334847
3Intrahepatic cholestasis (HP:0001406)6.44842294
4Abnormality of monocarboxylic acid metabolism (HP:0010996)6.07870308
5Xanthomatosis (HP:0000991)5.98441751
6Prolonged partial thromboplastin time (HP:0003645)5.70702399
7Hypobetalipoproteinemia (HP:0003563)5.33680141
8Hyperlipoproteinemia (HP:0010980)5.05433824
9Complement deficiency (HP:0004431)4.82514642
10Joint hemorrhage (HP:0005261)4.67378701
11Abnormality of glutamine family amino acid metabolism (HP:0010902)4.40166547
12* Hyperammonemia (HP:0001987)4.36054115
13Hypolipoproteinemia (HP:0010981)4.27608367
14Ketosis (HP:0001946)4.26279415
15Abnormality of the common coagulation pathway (HP:0010990)4.16866879
16Hyperglycinuria (HP:0003108)4.16776353
17Epidermoid cyst (HP:0200040)4.02949263
18Hypoalphalipoproteinemia (HP:0003233)4.02726041
19Abnormality of sulfur amino acid metabolism (HP:0004339)4.00925750
20Hyperglycinemia (HP:0002154)3.99453707
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.95540413
22Abnormality of serine family amino acid metabolism (HP:0010894)3.94974038
23Abnormality of glycine metabolism (HP:0010895)3.94974038
24Abnormality of aspartate family amino acid metabolism (HP:0010899)3.89902972
25Hypoglycemic coma (HP:0001325)3.83897294
26Fat malabsorption (HP:0002630)3.67963781
27Abnormality of methionine metabolism (HP:0010901)3.62294687
28Abnormality of complement system (HP:0005339)3.58800996
29Abnormality of the intrinsic pathway (HP:0010989)3.54299337
30Abnormality of fatty-acid metabolism (HP:0004359)3.50952334
31Flat acetabular roof (HP:0003180)3.48570908
32Hypercholesterolemia (HP:0003124)3.42857082
33Abnormality of pyrimidine metabolism (HP:0004353)3.40766402
34Ketoacidosis (HP:0001993)3.29174788
35Thin bony cortex (HP:0002753)3.22124313
36Abnormality of nucleobase metabolism (HP:0010932)3.20207822
37Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.18196260
38J-shaped sella turcica (HP:0002680)3.16047572
39Conjugated hyperbilirubinemia (HP:0002908)3.12208104
40Myocardial infarction (HP:0001658)3.10022489
41Abnormality of purine metabolism (HP:0004352)3.09928533
42Gout (HP:0001997)3.09767153
43Hyperbilirubinemia (HP:0002904)3.01178616
44Hepatocellular carcinoma (HP:0001402)2.97742026
45Systemic lupus erythematosus (HP:0002725)2.87110092
46Vascular calcification (HP:0004934)2.86085437
47Delayed CNS myelination (HP:0002188)2.83257803
48Dysostosis multiplex (HP:0000943)2.80226309
49Asymmetry of the thorax (HP:0001555)2.77620992
50Steatorrhea (HP:0002570)2.70947768
51Metabolic acidosis (HP:0001942)2.68696836
52Abnormality of serum amino acid levels (HP:0003112)2.65703085
53Spastic diplegia (HP:0001264)2.64664921
54Mucopolysacchariduria (HP:0008155)2.64449176
55Urinary glycosaminoglycan excretion (HP:0003541)2.64449176
56Dicarboxylic aciduria (HP:0003215)2.64428695
57Abnormality of dicarboxylic acid metabolism (HP:0010995)2.64428695
58Skin nodule (HP:0200036)2.62285189
59Cardiovascular calcification (HP:0011915)2.61428663
60Abdominal distention (HP:0003270)2.61303897
61Esophageal varix (HP:0002040)2.61195959
62Generalized aminoaciduria (HP:0002909)2.53104356
63Glomerulonephritis (HP:0000099)2.50769013
64Spontaneous abortion (HP:0005268)2.50717379
65Mitral stenosis (HP:0001718)2.49730912
66Abnormality of polysaccharide metabolism (HP:0011012)2.45772649
67Abnormality of glycosaminoglycan metabolism (HP:0004371)2.45772649
68Abnormality of mucopolysaccharide metabolism (HP:0011020)2.45772649
69Recurrent gram-negative bacterial infections (HP:0005420)2.45542051
70Eczematoid dermatitis (HP:0000976)2.43989057
71Right ventricular cardiomyopathy (HP:0011663)2.41731665
72Alkalosis (HP:0001948)2.36800075
73Distal lower limb muscle weakness (HP:0009053)2.33489094
74Broad face (HP:0000283)2.32719004
75Hypochromic microcytic anemia (HP:0004840)2.32449293
76Malnutrition (HP:0004395)2.30903269
77Gingival bleeding (HP:0000225)2.28960432
78Osteolytic defects of the phalanges of the hand (HP:0009771)2.28299163
79Osteolytic defects of the hand bones (HP:0009699)2.28299163
80Abnormality of glycolipid metabolism (HP:0010969)2.28230416
81Abnormality of liposaccharide metabolism (HP:0010968)2.28230416
82Abnormality of glycosphingolipid metabolism (HP:0004343)2.28230416
83Hypoglycemic seizures (HP:0002173)2.26288009
84Neonatal onset (HP:0003623)2.24671043
85Proximal tubulopathy (HP:0000114)2.24552690
86Hydroxyprolinuria (HP:0003080)2.23984207
87Abnormality of proline metabolism (HP:0010907)2.23984207
88Irritability (HP:0000737)2.22158959
89Increased cerebral lipofuscin (HP:0011813)2.21751871
90Late onset (HP:0003584)2.21098399
91* Lethargy (HP:0001254)2.21006076
92Hyperactive renin-angiotensin system (HP:0000841)2.20441863
93Menorrhagia (HP:0000132)2.20224581
94Amyloidosis (HP:0011034)2.16452462
95Vertebral compression fractures (HP:0002953)2.16139929
96Pancreatitis (HP:0001733)2.15577439
97Increased neuronal autofluorescent lipopigment (HP:0002074)2.15184682
98Sensorimotor neuropathy (HP:0007141)2.14909517
99Prolonged bleeding time (HP:0003010)2.12705641
100Hemorrhage of the eye (HP:0011885)2.10656411
101Increased purine levels (HP:0004368)2.09826592
102Hyperuricemia (HP:0002149)2.09826592
103Hyperacusis (HP:0010780)2.08467596
104Acanthocytosis (HP:0001927)2.07331962
105Thrombophlebitis (HP:0004418)2.06504866
106Nephritis (HP:0000123)2.05294628
107Hyperparathyroidism (HP:0000843)2.05261971
108Abnormal cartilage morphology (HP:0002763)2.04798419
109Vomiting (HP:0002013)2.03546521
110Abnormal gallbladder morphology (HP:0012437)2.01242380
111Sparse lateral eyebrow (HP:0005338)2.01150673
112Cholelithiasis (HP:0001081)2.00577361
113Enlarged kidneys (HP:0000105)2.00332180
114Germ cell neoplasia (HP:0100728)1.97431883
115Colitis (HP:0002583)1.96320648
116Rickets (HP:0002748)1.96314422
117Bone pain (HP:0002653)1.95159348
118Cervical subluxation (HP:0003308)1.95138570
119Increased serum ferritin (HP:0003281)1.95133223
120Interstitial pulmonary disease (HP:0006530)1.95063971
121Impaired platelet aggregation (HP:0003540)1.94691505
122Abnormal platelet function (HP:0011869)1.94691505
123Abnormal enzyme/coenzyme activity (HP:0012379)1.94482935
124Abnormality of transition element cation homeostasis (HP:0011030)1.92104852
125Hypophosphatemia (HP:0002148)1.91942003
126Epistaxis (HP:0000421)1.90951167
127Abnormality of iron homeostasis (HP:0011031)1.90521013
128Protrusio acetabuli (HP:0003179)1.89010237
129Cholecystitis (HP:0001082)1.86554638
130Abnormal gallbladder physiology (HP:0012438)1.86554638
131Nausea (HP:0002018)1.86314775
132Renal cortical cysts (HP:0000803)1.85064341
133Chronic diarrhea (HP:0002028)1.84367281
134Deformed sella turcica (HP:0002681)1.82078612
135Glycosuria (HP:0003076)1.81963861
136Abnormality of urine glucose concentration (HP:0011016)1.81963861
137Opisthotonus (HP:0002179)1.81534094
138Cellulitis (HP:0100658)1.81385372
139Coarse hair (HP:0002208)1.80850720
140Spinal cord compression (HP:0002176)1.80745991
141Pigmentary retinal degeneration (HP:0001146)1.80296058
142Spondylolisthesis (HP:0003302)1.79095619
143Gingivitis (HP:0000230)1.79031825
144Cerebral edema (HP:0002181)1.78905208
145Polycythemia (HP:0001901)1.78670097
146Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.77134186
147Cerebral aneurysm (HP:0004944)1.76865243
148Hypertriglyceridemia (HP:0002155)1.76435662
149Gastrointestinal inflammation (HP:0004386)1.75899651
150Severe short stature (HP:0003510)1.75223548
151Abnormality of the thoracic spine (HP:0100711)1.75159479
152Abnormality of the distal phalanges of the toes (HP:0010182)1.74262842
153Aneurysm (HP:0002617)1.73569903
154Distal lower limb amyotrophy (HP:0008944)1.73506366
155Abnormality of carpal bone ossification (HP:0006257)1.73087783
156Testicular neoplasm (HP:0010788)1.72880980
157Reticulocytosis (HP:0001923)1.72722113
158Nephrolithiasis (HP:0000787)1.72617285
159Abnormality of the gastric mucosa (HP:0004295)1.72391577
160Micronodular cirrhosis (HP:0001413)1.68836911
161Visceral angiomatosis (HP:0100761)1.68310521
162Recurrent abscess formation (HP:0002722)1.68073952
163Short nail (HP:0001799)1.67838456
164Polygenic inheritance (HP:0010982)1.66280217
165Hemangiomatosis (HP:0007461)1.63238979
166Inflammation of the large intestine (HP:0002037)1.63196302
167Abnormality of the distal phalanx of the thumb (HP:0009617)1.62622821
168Abnormality of macrophages (HP:0004311)1.62065010
169Protuberant abdomen (HP:0001538)1.61964590
170Blue sclerae (HP:0000592)1.61732706
171Vacuolated lymphocytes (HP:0001922)1.61391127
172Abnormality of the fingertips (HP:0001211)1.61387231
173Stroke (HP:0001297)1.61126470
174Abnormal platelet volume (HP:0011876)1.60228090
175Growth hormone excess (HP:0000845)1.59970030

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK5.28589287
2ERN14.49557215
3FGFR43.92577809
4SIK13.47742197
5TRIB33.17171358
6EPHA22.93494639
7PRPF4B2.69927495
8PKN22.63977432
9SMG12.62844867
10TAOK32.38437101
11SCYL22.37058294
12TYK22.12634440
13PTK62.01520746
14MST1R2.00162454
15INSRR1.87042460
16RPS6KB21.73428091
17FLT31.69942454
18MAP3K101.68080185
19ICK1.63991025
20EPHB11.60512408
21TGFBR21.56952046
22CDK121.54435455
23ERBB41.53647142
24MAPK111.48141185
25PIK3CA1.44847382
26NEK91.42577713
27FRK1.38737722
28RIPK41.38472339
29TRPM71.37964263
30LATS11.37200870
31MAP2K31.35994197
32PIK3CG1.35688649
33KDR1.33789642
34MAP4K11.33776321
35TIE11.33756041
36TBK11.31892018
37JAK11.30129244
38CAMK1D1.29771641
39WNK41.23439916
40GRK61.21988570
41CDK61.21735000
42JAK21.19365070
43RIPK11.17131770
44TESK21.14311153
45MAP3K71.12892837
46TESK11.08819005
47IRAK31.05082013
48CSK1.04363950
49NME21.01406094
50MAP3K31.01324028
51FGFR31.00431417
52PRKAA21.00343671
53LRRK20.98372722
54PAK40.97700566
55MAP3K140.95271245
56MAP3K130.93538681
57TAOK10.93310916
58EPHA30.92699184
59ABL20.92595244
60RPS6KA20.91191366
61EEF2K0.91028328
62MAP2K40.89290148
63PRKD20.88633260
64TNK20.85378957
65KIT0.82664250
66FGFR20.81479356
67DYRK1B0.80905125
68ERBB20.79564446
69PTK20.79172577
70HIPK20.77884611
71SGK30.77843372
72EIF2AK10.77796325
73MAPK150.77411681
74MAPK40.76567878
75CDC42BPA0.75834878
76MET0.75612023
77IKBKE0.74814673
78CSF1R0.74704585
79PDGFRA0.74410558
80PDK10.73570489
81GSK3A0.73362704
82NEK60.72803491
83RPS6KC10.70994113
84RPS6KL10.70994113
85PRKG20.70250388
86TAOK20.68793725
87STK100.67632217
88WNK30.67313409
89MAP2K20.65976699
90JAK30.65682288
91IRAK40.65098263
92GRK10.64778748
93ZAP700.64404096
94CAMK1G0.61726833
95MTOR0.58262522
96MAPK120.57613544
97MAP3K110.57005841
98MAPKAPK20.56233444
99RPS6KA60.55144494
100PRKACG0.55061781
101TTN0.53756591
102BTK0.52160410
103FES0.51543462
104MAP2K10.51510934
105CDK70.51287591
106BMX0.50399251
107PRKAA10.50332633
108ILK0.49924990
109MAP3K20.49900578
110STK38L0.49871088
111HCK0.47697621
112CDK40.47666228
113PRKD30.47238933
114CHUK0.46591366
115PDPK10.46565099
116MAP2K60.46374272
117IRAK10.46025429
118BLK0.45955917
119PAK20.45691546
120MAPK70.44987817
121MELK0.44845954
122MATK0.44777995
123PRKCZ0.44716480
124ITK0.43153446
125STK30.42759691
126IKBKB0.42588759
127RET0.42517893
128IGF1R0.41826001
129STK390.41356971
130MYLK0.41337150
131EGFR0.40245618
132SGK20.40025832
133PDGFRB0.39489956
134TEC0.39444628
135BMPR20.39261354
136PINK10.38940685
137MAPKAPK30.38590398
138PIM10.37415856
139OXSR10.35811622
140LMTK20.35694145
141DAPK20.34513480
142FER0.34369080
143PDK40.33893342
144PDK30.33893342
145MAP3K10.32592298

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.12277236
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.61185969
3Nitrogen metabolism_Homo sapiens_hsa009103.56526066
4Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004003.14923338
5Arginine biosynthesis_Homo sapiens_hsa002202.88432404
6Tryptophan metabolism_Homo sapiens_hsa003802.68476032
7Complement and coagulation cascades_Homo sapiens_hsa046102.64011764
8Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.61994621
9* Fatty acid degradation_Homo sapiens_hsa000712.61884621
10Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.59001898
11Pentose and glucuronate interconversions_Homo sapiens_hsa000402.54963237
12Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.51811582
13Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.35522969
14Butanoate metabolism_Homo sapiens_hsa006502.16525905
15Peroxisome_Homo sapiens_hsa041462.06791759
16Propanoate metabolism_Homo sapiens_hsa006402.02551182
17Drug metabolism - cytochrome P450_Homo sapiens_hsa009822.01375324
18* PPAR signaling pathway_Homo sapiens_hsa033201.94252216
19Histidine metabolism_Homo sapiens_hsa003401.89721880
20Caffeine metabolism_Homo sapiens_hsa002321.88746749
21Acute myeloid leukemia_Homo sapiens_hsa052211.83667262
22* Fatty acid metabolism_Homo sapiens_hsa012121.82990562
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.82542550
24Chemical carcinogenesis_Homo sapiens_hsa052041.81508318
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.79259266
26Staphylococcus aureus infection_Homo sapiens_hsa051501.77408020
27beta-Alanine metabolism_Homo sapiens_hsa004101.74614979
28Drug metabolism - other enzymes_Homo sapiens_hsa009831.71391416
29Retinol metabolism_Homo sapiens_hsa008301.65241921
302-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.64947994
31Bile secretion_Homo sapiens_hsa049761.59160547
32Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.52727416
33Chronic myeloid leukemia_Homo sapiens_hsa052201.50291371
34Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.48814135
35Selenocompound metabolism_Homo sapiens_hsa004501.47441564
36Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.46829153
37Phenylalanine metabolism_Homo sapiens_hsa003601.44683486
38Pyruvate metabolism_Homo sapiens_hsa006201.42755087
39Starch and sucrose metabolism_Homo sapiens_hsa005001.40134344
40Non-small cell lung cancer_Homo sapiens_hsa052231.36542382
41Sulfur metabolism_Homo sapiens_hsa009201.34637780
42ABC transporters_Homo sapiens_hsa020101.28979345
43Pancreatic cancer_Homo sapiens_hsa052121.26040751
44Tyrosine metabolism_Homo sapiens_hsa003501.24468847
45B cell receptor signaling pathway_Homo sapiens_hsa046621.24185444
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.19505431
47Carbon metabolism_Homo sapiens_hsa012001.18747392
48Fatty acid elongation_Homo sapiens_hsa000621.17970455
49Fat digestion and absorption_Homo sapiens_hsa049751.17923126
50Folate biosynthesis_Homo sapiens_hsa007901.15419208
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.15110041
52Cyanoamino acid metabolism_Homo sapiens_hsa004601.14978651
53Biosynthesis of amino acids_Homo sapiens_hsa012301.13871416
54Thyroid cancer_Homo sapiens_hsa052161.12342196
55Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.11472130
56VEGF signaling pathway_Homo sapiens_hsa043701.04998937
57Vitamin digestion and absorption_Homo sapiens_hsa049771.04698605
58Leukocyte transendothelial migration_Homo sapiens_hsa046701.04248491
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04106255
60Lysine degradation_Homo sapiens_hsa003101.03772817
61Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.03763661
62Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99108330
63Endometrial cancer_Homo sapiens_hsa052130.97713609
64Platelet activation_Homo sapiens_hsa046110.97681219
65Maturity onset diabetes of the young_Homo sapiens_hsa049500.94435278
66Arginine and proline metabolism_Homo sapiens_hsa003300.93831615
67Leishmaniasis_Homo sapiens_hsa051400.93510904
68Prolactin signaling pathway_Homo sapiens_hsa049170.93294535
69Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.89560841
70Sulfur relay system_Homo sapiens_hsa041220.88270442
71Toxoplasmosis_Homo sapiens_hsa051450.87590497
72Steroid biosynthesis_Homo sapiens_hsa001000.85836014
73Osteoclast differentiation_Homo sapiens_hsa043800.84725454
74Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.84581284
75Glycerolipid metabolism_Homo sapiens_hsa005610.84402809
76Renal cell carcinoma_Homo sapiens_hsa052110.83510875
77AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.83103372
78mTOR signaling pathway_Homo sapiens_hsa041500.82531942
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.80843259
80Influenza A_Homo sapiens_hsa051640.80407612
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78153809
82Small cell lung cancer_Homo sapiens_hsa052220.76789061
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75977536
84Toll-like receptor signaling pathway_Homo sapiens_hsa046200.75834631
85Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.75481771
86TNF signaling pathway_Homo sapiens_hsa046680.75423641
87Hepatitis B_Homo sapiens_hsa051610.73958129
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73206508
89Inositol phosphate metabolism_Homo sapiens_hsa005620.72735630
90Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.71297902
91Sphingolipid metabolism_Homo sapiens_hsa006000.70820231
92T cell receptor signaling pathway_Homo sapiens_hsa046600.68651955
93Glutathione metabolism_Homo sapiens_hsa004800.68484585
94Choline metabolism in cancer_Homo sapiens_hsa052310.67154842
95Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66666155
96Pentose phosphate pathway_Homo sapiens_hsa000300.64498873
97Thyroid hormone signaling pathway_Homo sapiens_hsa049190.62904006
98Prostate cancer_Homo sapiens_hsa052150.62247816
99One carbon pool by folate_Homo sapiens_hsa006700.60730024
100Vitamin B6 metabolism_Homo sapiens_hsa007500.58560536
101Estrogen signaling pathway_Homo sapiens_hsa049150.57710264
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.57512703
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.56548753
104Measles_Homo sapiens_hsa051620.56498506
105Focal adhesion_Homo sapiens_hsa045100.55945445
106Tuberculosis_Homo sapiens_hsa051520.52017744
107Hematopoietic cell lineage_Homo sapiens_hsa046400.51982739
108Fatty acid biosynthesis_Homo sapiens_hsa000610.51519147
109Apoptosis_Homo sapiens_hsa042100.51436197
110Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.51207917
111Jak-STAT signaling pathway_Homo sapiens_hsa046300.49569646
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.48506209
113Neurotrophin signaling pathway_Homo sapiens_hsa047220.48318474
114Metabolic pathways_Homo sapiens_hsa011000.38716297
115Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.38306619
116* Insulin resistance_Homo sapiens_hsa049310.35855766
117Fructose and mannose metabolism_Homo sapiens_hsa000510.35132893
118Galactose metabolism_Homo sapiens_hsa000520.33895521
119* Adipocytokine signaling pathway_Homo sapiens_hsa049200.30461407
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.27757516
121Prion diseases_Homo sapiens_hsa050200.19820801
122Glycosaminoglycan degradation_Homo sapiens_hsa005310.18507136
123Linoleic acid metabolism_Homo sapiens_hsa005910.14262301
124Glycerophospholipid metabolism_Homo sapiens_hsa005640.11799737
125Renin-angiotensin system_Homo sapiens_hsa046140.08929292
126* AMPK signaling pathway_Homo sapiens_hsa041520.05205382
127Carbohydrate digestion and absorption_Homo sapiens_hsa049730.03579908
128Lysosome_Homo sapiens_hsa041420.02650510
129* Glucagon signaling pathway_Homo sapiens_hsa049220.02522901
130Other glycan degradation_Homo sapiens_hsa005110.01845433
131Longevity regulating pathway - mammal_Homo sapiens_hsa04211-0.1839146
132Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534-0.1709305
133Terpenoid backbone biosynthesis_Homo sapiens_hsa00900-0.1565777
134Bladder cancer_Homo sapiens_hsa05219-0.1557809
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141-0.1545149
136Thyroid hormone synthesis_Homo sapiens_hsa04918-0.1355148
137Pertussis_Homo sapiens_hsa05133-0.1292696
138Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604-0.1146559
139Arachidonic acid metabolism_Homo sapiens_hsa00590-0.0990918
140Central carbon metabolism in cancer_Homo sapiens_hsa05230-0.0771284
141Amoebiasis_Homo sapiens_hsa05146-0.0699535
142Mineral absorption_Homo sapiens_hsa04978-0.0582727
143Insulin signaling pathway_Homo sapiens_hsa04910-0.0549311
144Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520-0.0528081
145Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0363968
146Protein digestion and absorption_Homo sapiens_hsa04974-0.0347907
147Hepatitis C_Homo sapiens_hsa05160-0.0345471

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