CPT1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene, a member of the carnitine/choline acetyltransferase family, is the rate-controlling enzyme of the long-chain fatty acid beta-oxidation pathway in muscle mitochondria. This enzyme is required for the net transport of long-chain fatty acyl-CoAs from the cytoplasm into the mitochondria. Multiple transcript variants encoding different isoforms have been found for this gene, and read-through transcripts are expressed from the upstream locus that include exons from this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sarcomere organization (GO:0045214)8.55825641
2cardiac myofibril assembly (GO:0055003)8.04421620
3tricarboxylic acid cycle (GO:0006099)7.64907405
4negative regulation of potassium ion transmembrane transporter activity (GO:1901017)7.63774686
5myofibril assembly (GO:0030239)7.31796665
6actin-myosin filament sliding (GO:0033275)7.04912540
7muscle filament sliding (GO:0030049)7.04912540
8negative regulation of potassium ion transmembrane transport (GO:1901380)6.87487246
9regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)6.46469262
10cardiac muscle contraction (GO:0060048)6.33994182
11positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)6.22178441
12regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO6.21203370
13regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)6.17226324
14cardiac muscle cell development (GO:0055013)5.97546519
15regulation of acyl-CoA biosynthetic process (GO:0050812)5.87955305
16actin-mediated cell contraction (GO:0070252)5.86740596
17regulation of skeletal muscle contraction (GO:0014819)5.78676654
18plasma membrane repair (GO:0001778)5.77207540
19regulation of relaxation of muscle (GO:1901077)5.69141103
20regulation of actin filament-based movement (GO:1903115)5.63663370
21cardiac cell development (GO:0055006)5.60594294
22regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)5.45258483
23actomyosin structure organization (GO:0031032)5.40715993
24regulation of cofactor metabolic process (GO:0051193)5.38543014
25regulation of coenzyme metabolic process (GO:0051196)5.38543014
26cardiac muscle tissue morphogenesis (GO:0055008)5.30065040
27* carnitine shuttle (GO:0006853)5.29630486
28adult heart development (GO:0007512)5.26119219
29cardiac muscle hypertrophy (GO:0003300)5.21337260
30ventricular cardiac muscle cell action potential (GO:0086005)5.18061162
31striated muscle contraction (GO:0006941)5.12392455
32regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)5.10317518
33regulation of sequestering of triglyceride (GO:0010889)5.04308264
34regulation of sarcomere organization (GO:0060297)5.01704502
35ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.00833922
36sarcoplasmic reticulum calcium ion transport (GO:0070296)5.00333211
37striated muscle hypertrophy (GO:0014897)4.96584936
38bundle of His cell to Purkinje myocyte communication (GO:0086069)4.89490559
39NADH metabolic process (GO:0006734)4.87291066
40heart trabecula formation (GO:0060347)4.85439697
41response to inactivity (GO:0014854)4.78384481
42muscle tissue morphogenesis (GO:0060415)4.76817945
43regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)4.76178345
44* fatty acid transmembrane transport (GO:1902001)4.67307256
45regulation of striated muscle contraction (GO:0006942)4.63130468
46heart process (GO:0003015)4.61561052
47heart contraction (GO:0060047)4.61561052
48regulation of cell communication by electrical coupling (GO:0010649)4.57870985
49actin filament-based movement (GO:0030048)4.39902215
50cell communication by electrical coupling involved in cardiac conduction (GO:0086064)4.39777413
51regulation of the force of heart contraction (GO:0002026)4.37937728
52muscle hypertrophy (GO:0014896)4.37791221
53regulation of sulfur metabolic process (GO:0042762)4.35038729
54regulation of fatty acid oxidation (GO:0046320)4.27616781
55regulation of membrane repolarization (GO:0060306)4.26128823
56cell communication involved in cardiac conduction (GO:0086065)4.22630302
57* carnitine transmembrane transport (GO:1902603)4.22531849
582-oxoglutarate metabolic process (GO:0006103)4.12598808
59skeletal muscle adaptation (GO:0043501)4.10296099
60mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.08987261
61oxidative phosphorylation (GO:0006119)4.08676921
62respiratory electron transport chain (GO:0022904)4.04849918
63mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.00760192
64response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.97360119
65electron transport chain (GO:0022900)3.93702643
66* amino-acid betaine transport (GO:0015838)3.89964745
67* carnitine transport (GO:0015879)3.89964745
68* fatty acid beta-oxidation (GO:0006635)3.89846548
69regulation of cardiac muscle contraction (GO:0055117)3.80327879
70regulation of cardiac muscle cell contraction (GO:0086004)3.76473027
71response to muscle activity (GO:0014850)3.76461586
72cardiac muscle hypertrophy in response to stress (GO:0014898)3.75785766
73muscle hypertrophy in response to stress (GO:0003299)3.75785766
74cardiac muscle adaptation (GO:0014887)3.75785766
75cell communication by electrical coupling (GO:0010644)3.75009297
76creatine metabolic process (GO:0006600)3.72558131
77energy coupled proton transport, down electrochemical gradient (GO:0015985)3.71648008
78ATP synthesis coupled proton transport (GO:0015986)3.71648008
79succinate metabolic process (GO:0006105)3.71533741
80aspartate family amino acid catabolic process (GO:0009068)3.71505598
81negative regulation of necroptotic process (GO:0060546)3.69821513
82negative regulation of potassium ion transport (GO:0043267)3.67891452
83negative regulation of cardiac muscle cell apoptotic process (GO:0010667)3.63968804
84regulation of heart rate (GO:0002027)3.63766984
85lysine metabolic process (GO:0006553)3.63135979
86lysine catabolic process (GO:0006554)3.63135979
87cardiac muscle cell action potential involved in contraction (GO:0086002)3.61198773
88cardiac muscle cell action potential (GO:0086001)3.59719293
89positive regulation of calcium ion transmembrane transporter activity (GO:1901021)3.59053085
90relaxation of cardiac muscle (GO:0055119)3.54320962
91skeletal muscle contraction (GO:0003009)3.49755373
92muscle adaptation (GO:0043500)3.48462111
93regulation of ATPase activity (GO:0043462)3.44970402
94regulation of ATP catabolic process (GO:1903289)3.44970402
95striated muscle cell development (GO:0055002)3.43796863
96negative regulation of necrotic cell death (GO:0060547)3.43451052
97negative regulation of protein localization to cell surface (GO:2000009)3.43295568
98muscle contraction (GO:0006936)3.42009450
99tricarboxylic acid metabolic process (GO:0072350)3.40723393
100regulation of cardioblast differentiation (GO:0051890)3.37785387
101regulation of heart contraction (GO:0008016)3.33953834
102negative regulation of striated muscle cell apoptotic process (GO:0010664)3.33871304
103regulation of necroptotic process (GO:0060544)3.31123179
104ventricular cardiac muscle cell development (GO:0055015)3.29693700
105negative regulation of erythrocyte differentiation (GO:0045647)3.25614996
106striated muscle atrophy (GO:0014891)3.24163573
107biotin metabolic process (GO:0006768)3.23688026
108striated muscle adaptation (GO:0014888)3.22345101
109regulation of calcium ion transmembrane transport (GO:1903169)3.20392108
110regulation of calcium ion transmembrane transporter activity (GO:1901019)3.20392108
111muscle system process (GO:0003012)3.20247941
112positive regulation of myotube differentiation (GO:0010831)3.15640188
113glycogen catabolic process (GO:0005980)3.10720173
114germinal center formation (GO:0002467)3.07969326
115mitochondrial genome maintenance (GO:0000002)3.03552688
116cardiac ventricle formation (GO:0003211)2.99905275
117cellular response to epinephrine stimulus (GO:0071872)2.98463652
118glucan catabolic process (GO:0009251)2.98191923
119cardiac chamber formation (GO:0003207)2.98148327
120membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.96053189
121mannose metabolic process (GO:0006013)2.95367843
122positive regulation of cation channel activity (GO:2001259)2.84188181
123response to epinephrine (GO:0071871)2.82553338
124cellular polysaccharide catabolic process (GO:0044247)2.80913454
125negative regulation of myotube differentiation (GO:0010832)2.80780013
126regulation of muscle contraction (GO:0006937)2.79202115
127negative regulation of cell size (GO:0045792)2.78734350
128positive regulation of gamma-delta T cell activation (GO:0046645)2.77203080
129negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.76588006
130negative regulation of cell killing (GO:0031342)2.76588006
131skeletal muscle fiber development (GO:0048741)2.75152692
132histone H3-K9 demethylation (GO:0033169)2.74461695
133muscle atrophy (GO:0014889)2.72853597
134regulation of gamma-delta T cell activation (GO:0046643)2.72785081
135muscle fiber development (GO:0048747)2.72064470
136regulation of muscle system process (GO:0090257)2.72010365
137activation of protein kinase A activity (GO:0034199)2.71633006
138regulation of ARF GTPase activity (GO:0032312)2.69337238

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse8.69213688
2* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.82009125
3EP300_21415370_ChIP-Seq_HL-1_Mouse4.62057249
4ESRRB_18555785_ChIP-Seq_MESCs_Mouse4.43389514
5TBX20_22328084_ChIP-Seq_HEART_Mouse3.96105273
6TBX20_22080862_ChIP-Seq_HEART_Mouse3.96105273
7RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.42795912
8ZNF263_19887448_ChIP-Seq_K562_Human3.24359921
9MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.92603897
10ESR1_20079471_ChIP-ChIP_T-47D_Human2.62300610
11VDR_21846776_ChIP-Seq_THP-1_Human2.55692256
12RARG_19884340_ChIP-ChIP_MEFs_Mouse2.45450115
13TCF7_22412390_ChIP-Seq_EML_Mouse2.39964810
14ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.38701653
15EZH2_22144423_ChIP-Seq_EOC_Human2.23189457
16CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.22713232
17GATA4_21415370_ChIP-Seq_HL-1_Mouse2.21402681
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.21334595
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.15452323
20MYC_22102868_ChIP-Seq_BL_Human2.09924984
21EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.09344717
22PPARD_23208498_ChIP-Seq_MDA-MB-231_Human2.06987660
23ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.04717385
24IRF8_22096565_ChIP-ChIP_GC-B_Human2.04138501
25NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.03008161
26CDX2_19796622_ChIP-Seq_MESCs_Mouse1.87161415
27EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.86419459
28NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.83158139
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.73482818
30CLOCK_20551151_ChIP-Seq_293T_Human1.73413573
31BP1_19119308_ChIP-ChIP_Hs578T_Human1.71392947
32PPARA_22158963_ChIP-Seq_LIVER_Mouse1.70911229
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.68982209
34KDM2B_26808549_Chip-Seq_K562_Human1.66871947
35MAF_26560356_Chip-Seq_TH1_Human1.65010348
36LXR_22158963_ChIP-Seq_LIVER_Mouse1.64865189
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.64663466
38GATA1_19941827_ChIP-Seq_MEL_Mouse1.62332437
39STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.60153309
40CTCF_27219007_Chip-Seq_ERYTHROID_Human1.58029192
41FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.56219128
42* MAF_26560356_Chip-Seq_TH2_Human1.54402900
43ELF1_20517297_ChIP-Seq_JURKAT_Human1.51430513
44KDM2B_26808549_Chip-Seq_JURKAT_Human1.51416222
45VDR_24763502_ChIP-Seq_THP-1_Human1.50329912
46SA1_27219007_Chip-Seq_ERYTHROID_Human1.48546370
47TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.48315275
48NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.46976406
49ZFP281_18757296_ChIP-ChIP_E14_Mouse1.46852745
50DNAJC2_21179169_ChIP-ChIP_NT2_Human1.43588559
51UTX_26944678_Chip-Seq_JUKART_Human1.40694446
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.39388251
53CREB1_26743006_Chip-Seq_LNCaP_Human1.39305691
54GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.37524247
55SPI1_23127762_ChIP-Seq_K562_Human1.35503525
56* RXR_22158963_ChIP-Seq_LIVER_Mouse1.33849938
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.33630961
58RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.32337868
59RUNX_20019798_ChIP-Seq_JUKART_Human1.32090491
60PPAR_26484153_Chip-Seq_NCI-H1993_Human1.31928183
61* TET1_21451524_ChIP-Seq_MESCs_Mouse1.31508751
62* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30961144
63OCT4_19829295_ChIP-Seq_ESCs_Human1.30306954
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.29017316
65* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.27904955
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.24473438
67CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.24293968
68SA1_27219007_Chip-Seq_Bcells_Human1.22320552
69RARB_27405468_Chip-Seq_BRAIN_Mouse1.19772522
70PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.18400651
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.18223286
72ESR2_21235772_ChIP-Seq_MCF-7_Human1.18219160
73MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18086755
74EZH2_27294783_Chip-Seq_ESCs_Mouse1.17085022
75* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.16702876
76TP63_22573176_ChIP-Seq_HFKS_Human1.16081397
77RUNX1_22412390_ChIP-Seq_EML_Mouse1.14826527
78PHF8_20622854_ChIP-Seq_HELA_Human1.12072359
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.11544156
80* CTCF_27219007_Chip-Seq_Bcells_Human1.10865910
81LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.08909443
82SCL_19346495_ChIP-Seq_HPC-7_Human1.07983511
83ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.07211383
84KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06122459
85CTCF_26484167_Chip-Seq_Bcells_Mouse1.06114165
86IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.05997140
87ISL1_27105846_Chip-Seq_CPCs_Mouse1.05897466
88ZNF274_21170338_ChIP-Seq_K562_Hela1.05823350
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05448798
90* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.05251332
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04968878
92MYC_27129775_Chip-Seq_CORNEA_Mouse1.02861783
93IKZF1_21737484_ChIP-ChIP_HCT116_Human1.02261702
94PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.01108204
95FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.00660114
96RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.00422358
97AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99717658
98NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.99450084
99GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98253031
100KDM2B_26808549_Chip-Seq_DND41_Human0.98217594
101PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.97979726
102RUNX1_27514584_Chip-Seq_MCF-7_Human0.97921819
103SUZ12_27294783_Chip-Seq_ESCs_Mouse0.96641145
104* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95767241
105SPI1_20517297_ChIP-Seq_HL60_Human0.95235629
106SOX9_24532713_ChIP-Seq_HFSC_Mouse0.94118453
107FOXA2_19822575_ChIP-Seq_HepG2_Human0.93927971
108GATA2_21666600_ChIP-Seq_HMVEC_Human0.92753098
109SMC3_22415368_ChIP-Seq_MEFs_Mouse0.92605913
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91023657
111GATA1_19941826_ChIP-Seq_K562_Human0.90902411
112STAT3_1855785_ChIP-Seq_MESCs_Mouse0.89766021
113TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89562876
114P68_20966046_ChIP-Seq_HELA_Human0.89011536
115BCAT_22108803_ChIP-Seq_LS180_Human0.88956503
116DROSHA_22980978_ChIP-Seq_HELA_Human0.88381729
117EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.88221380
118CTNNB1_20460455_ChIP-Seq_HCT116_Human0.88143912
119OCT4_20526341_ChIP-Seq_ESCs_Human0.88102381
120GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87525383
121FOXH1_21741376_ChIP-Seq_ESCs_Human0.86888088
122HIF1A_21447827_ChIP-Seq_MCF-7_Human0.86645623
123STAT6_21828071_ChIP-Seq_BEAS2B_Human0.84378228
124SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.81503325
125BCOR_27268052_Chip-Seq_Bcells_Human0.81483320
126GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.81328748
127CJUN_26792858_Chip-Seq_BT549_Human0.80080201
128GATA2_19941826_ChIP-Seq_K562_Human0.79195159
129TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.78707105
130TRIM28_21343339_ChIP-Seq_HEK293_Human0.78546722
131RACK7_27058665_Chip-Seq_MCF-7_Human0.78362149
132ATF3_27146783_Chip-Seq_COLON_Human0.76724060
133SMAD3_21741376_ChIP-Seq_HESCs_Human0.76718173
134KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.75669453
135LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.75112765
136LXR_22292898_ChIP-Seq_THP-1_Human0.74797072
137EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.74407035
138YY1_22570637_ChIP-Seq_MALME-3M_Human0.74308359
139BCL6_27268052_Chip-Seq_Bcells_Human0.73451363
140CTCF_21964334_Chip-Seq_Bcells_Human0.72276944
141E2F1_20622854_ChIP-Seq_HELA_Human0.72048525
142CTCF_21964334_ChIP-Seq_BJAB-B_Human0.71413073
143ELK3_25401928_ChIP-Seq_HUVEC_Human0.70451897
144GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.70395448
145SMAD4_21741376_ChIP-Seq_HESCs_Human0.69105332
146GATA1_22025678_ChIP-Seq_K562_Human0.67481398
147NR3C1_23031785_ChIP-Seq_PC12_Mouse0.66936311
148WT1_25993318_ChIP-Seq_PODOCYTE_Human0.66635989
149SMC4_20622854_ChIP-Seq_HELA_Human0.66141183
150TP53_23651856_ChIP-Seq_MEFs_Mouse0.65674776
151MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.65605076
152SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.65448539
153FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.64653872

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis6.55903316
2MP0003646_muscle_fatigue5.95878172
3MP0004084_abnormal_cardiac_muscle5.38258105
4MP0000751_myopathy4.99697931
5MP0004215_abnormal_myocardial_fiber4.44963245
6MP0004036_abnormal_muscle_relaxation4.17056160
7MP0000749_muscle_degeneration3.91409781
8MP0005330_cardiomyopathy3.85290018
9MP0004087_abnormal_muscle_fiber3.12241161
10MP0004130_abnormal_muscle_cell3.09739399
11MP0002972_abnormal_cardiac_muscle3.00570464
12MP0008775_abnormal_heart_ventricle2.87781830
13MP0005620_abnormal_muscle_contractility2.69861736
14MP0003137_abnormal_impulse_conducting2.66815870
15MP0000750_abnormal_muscle_regeneration2.62893636
16MP0002106_abnormal_muscle_physiology2.58259664
17MP0010630_abnormal_cardiac_muscle2.56683679
18MP0005385_cardiovascular_system_phenoty2.53108272
19MP0001544_abnormal_cardiovascular_syste2.53108272
20MP0004145_abnormal_muscle_electrophysio2.47635945
21MP0002269_muscular_atrophy2.36712799
22MP0006138_congestive_heart_failure2.32855631
23MP0005670_abnormal_white_adipose2.31320364
24MP0004484_altered_response_of2.30260216
25MP0005666_abnormal_adipose_tissue2.11810845
26MP0003828_pulmonary_edema2.09189556
27MP0005369_muscle_phenotype2.06324552
28MP0006036_abnormal_mitochondrial_physio2.05426968
29MP0000759_abnormal_skeletal_muscle2.04760064
30MP0000747_muscle_weakness2.03400348
31MP0004233_abnormal_muscle_weight2.01922342
32MP0003221_abnormal_cardiomyocyte_apopto2.01638105
33MP0004085_abnormal_heartbeat1.97697474
34MP0004510_myositis1.71704126
35MP0002332_abnormal_exercise_endurance1.62908579
36MP0002127_abnormal_cardiovascular_syste1.53550579
37MP0003950_abnormal_plasma_membrane1.51586203
38MP0004185_abnormal_adipocyte_glucose1.48265991
39MP0005375_adipose_tissue_phenotype1.37158889
40MP0002971_abnormal_brown_adipose1.20197293
41MP0003567_abnormal_fetal_cardiomyocyte1.16829022
42MP0003303_peritoneal_inflammation1.16160622
43MP0006035_abnormal_mitochondrial_morpho1.13880916
44MP0000343_altered_response_to1.13640949
45MP0000266_abnormal_heart_morphology1.13476694
46MP0004381_abnormal_hair_follicle1.08226241
47MP0003436_decreased_susceptibility_to1.05969047
48MP0002234_abnormal_pharynx_morphology1.04789690
49MP0010368_abnormal_lymphatic_system1.01329196
50MP0003279_aneurysm0.99643890
51MP0001790_abnormal_immune_system0.98508530
52MP0005387_immune_system_phenotype0.98508530
53MP0001800_abnormal_humoral_immune0.95462282
54MP0003763_abnormal_thymus_physiology0.93407912
55MP0003172_abnormal_lysosome_physiology0.93341759
56MP0009278_abnormal_bone_marrow0.90447104
57MP0005165_increased_susceptibility_to0.89388949
58MP0002108_abnormal_muscle_morphology0.88587661
59MP0005266_abnormal_metabolism0.88324821
60MP0008260_abnormal_autophagy0.87364404
61MP0005409_darkened_coat_color0.85607381
62MP0001835_abnormal_antigen_presentation0.85142296
63MP0003724_increased_susceptibility_to0.82949596
64MP0000230_abnormal_systemic_arterial0.79142459
65MP0000003_abnormal_adipose_tissue0.78717256
66MP0002933_joint_inflammation0.78653877
67MP0005623_abnormal_meninges_morphology0.76612604
68MP0003705_abnormal_hypodermis_morpholog0.75616998
69MP0000013_abnormal_adipose_tissue0.75066968
70MP0002128_abnormal_blood_circulation0.74196929
71MP0004043_abnormal_pH_regulation0.74058750
72MP0005410_abnormal_fertilization0.73676578
73MP0005451_abnormal_body_composition0.73561802
74MP0008569_lethality_at_weaning0.72580664
75MP0000685_abnormal_immune_system0.72459185
76MP0001661_extended_life_span0.71040302
77MP0005025_abnormal_response_to0.70369588
78MP0003879_abnormal_hair_cell0.69380216
79MP0001348_abnormal_lacrimal_gland0.68104932
80MP0003566_abnormal_cell_adhesion0.67576856
81MP0001879_abnormal_lymphatic_vessel0.67390685
82MP0002723_abnormal_immune_serum0.66182924
83MP0000733_abnormal_muscle_development0.65650743
84MP0002078_abnormal_glucose_homeostasis0.65590542
85MP0008961_abnormal_basal_metabolism0.63787031
86MP0008438_abnormal_cutaneous_collagen0.62222305
87MP0003806_abnormal_nucleotide_metabolis0.60629787
88MP0005000_abnormal_immune_tolerance0.59877232
89MP0002419_abnormal_innate_immunity0.58986802
90MP0002452_abnormal_antigen_presenting0.58202291
91MP0009115_abnormal_fat_cell0.57692958
92MP0005319_abnormal_enzyme/_coenzyme0.57213163
93MP0000678_abnormal_parathyroid_gland0.56831648
94MP0002420_abnormal_adaptive_immunity0.56652286
95MP0001819_abnormal_immune_cell0.55818397
96MP0005334_abnormal_fat_pad0.55780191
97MP0002138_abnormal_hepatobiliary_system0.55427788
98MP0001986_abnormal_taste_sensitivity0.55223770
99* MP0005535_abnormal_body_temperature0.53961628
100MP0008874_decreased_physiological_sensi0.53750429
101MP0004272_abnormal_basement_membrane0.53619891
102MP0001873_stomach_inflammation0.52902730
103MP0002132_abnormal_respiratory_system0.52845297
104MP0002822_catalepsy0.52058973
105MP0002118_abnormal_lipid_homeostasis0.51444394
106MP0005275_abnormal_skin_tensile0.51269623
107MP0002909_abnormal_adrenal_gland0.49392891
108MP0000767_abnormal_smooth_muscle0.48867639
109MP0002970_abnormal_white_adipose0.48676662
110MP0001849_ear_inflammation0.48155994
111MP0005671_abnormal_response_to0.47060581
112MP0000716_abnormal_immune_system0.45593392
113MP0002396_abnormal_hematopoietic_system0.44116515
114MP0003656_abnormal_erythrocyte_physiolo0.43858388
115MP0002398_abnormal_bone_marrow0.43289317
116MP0003948_abnormal_gas_homeostasis0.43119017
117MP0003984_embryonic_growth_retardation0.42296635
118MP0002925_abnormal_cardiovascular_devel0.41728507
119MP0005187_abnormal_penis_morphology0.41482779
120MP0002088_abnormal_embryonic_growth/wei0.40978214
121MP0005584_abnormal_enzyme/coenzyme_acti0.40716981
122MP0005332_abnormal_amino_acid0.40147330
123MP0009785_altered_susceptibility_to0.39209413
124MP0002249_abnormal_larynx_morphology0.39071508
125MP0004147_increased_porphyrin_level0.38611577
126MP0005058_abnormal_lysosome_morphology0.37714181
127MP0005167_abnormal_blood-brain_barrier0.37578170
128MP0005452_abnormal_adipose_tissue0.36518346
129MP0001784_abnormal_fluid_regulation0.35150501
130MP0001614_abnormal_blood_vessel0.34926390
131MP0005448_abnormal_energy_balance0.30316217
132MP0003959_abnormal_lean_body0.29510881
133MP0009384_cardiac_valve_regurgitation0.28159721
134MP0001727_abnormal_embryo_implantation0.27938188
135MP0001853_heart_inflammation0.27135285
136MP0003045_fibrosis0.26877024
137MP0003195_calcinosis0.25912743
138MP0005595_abnormal_vascular_smooth0.24856482
139MP0001672_abnormal_embryogenesis/_devel0.22221001
140MP0005380_embryogenesis_phenotype0.22221001
141MP0005376_homeostasis/metabolism_phenot0.21169205
142MP0000249_abnormal_blood_vessel0.20116749
143MP0009840_abnormal_foam_cell0.18968563

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.69230230
2Exercise-induced myalgia (HP:0003738)6.41005967
3Ventricular tachycardia (HP:0004756)6.32644573
4Calf muscle hypertrophy (HP:0008981)6.22094310
5Exercise-induced muscle cramps (HP:0003710)6.01831713
6Muscle hypertrophy of the lower extremities (HP:0008968)5.80675317
7Myoglobinuria (HP:0002913)5.77739608
8Muscle fiber splitting (HP:0003555)5.54195265
9Atrial fibrillation (HP:0005110)5.44755204
10Primary atrial arrhythmia (HP:0001692)5.06897715
11Lipoatrophy (HP:0100578)5.04729796
12Abnormality of the calf musculature (HP:0001430)5.01808766
13Hyporeflexia of lower limbs (HP:0002600)4.94445701
14Abnormality of the left ventricular outflow tract (HP:0011103)4.92067281
15Subaortic stenosis (HP:0001682)4.92067281
16Supraventricular tachycardia (HP:0004755)4.90254146
17Supraventricular arrhythmia (HP:0005115)4.81020484
18Centrally nucleated skeletal muscle fibers (HP:0003687)4.66624878
19Rhabdomyolysis (HP:0003201)4.60035219
20Myopathic facies (HP:0002058)4.40642122
21Right ventricular cardiomyopathy (HP:0011663)4.38416780
22Syncope (HP:0001279)4.30668591
23Dilated cardiomyopathy (HP:0001644)4.28054142
24Bundle branch block (HP:0011710)4.24925129
25Palpitations (HP:0001962)4.18013445
26EMG: myopathic abnormalities (HP:0003458)4.00400107
27Asymmetric septal hypertrophy (HP:0001670)3.99096275
28Increased connective tissue (HP:0009025)3.95810494
29Difficulty running (HP:0009046)3.92793557
30Prolonged QT interval (HP:0001657)3.92326405
31Ventricular arrhythmia (HP:0004308)3.74199611
32Heart block (HP:0012722)3.55263790
33Distal arthrogryposis (HP:0005684)3.54652313
34Atrioventricular block (HP:0001678)3.46184457
35Hepatic necrosis (HP:0002605)3.39708052
36Abnormal atrioventricular conduction (HP:0005150)3.33607132
37Round ear (HP:0100830)3.28124366
38Ventricular fibrillation (HP:0001663)3.26566737
39Myotonia (HP:0002486)3.25115957
40Ulnar deviation of the wrist (HP:0003049)3.22106254
41Hypoglycemic coma (HP:0001325)3.17836203
42Abnormality of fatty-acid metabolism (HP:0004359)3.06916893
43Distal lower limb amyotrophy (HP:0008944)3.05937668
44Abnormal mitochondria in muscle tissue (HP:0008316)3.01679426
45Type 1 muscle fiber predominance (HP:0003803)3.00311042
46Ketoacidosis (HP:0001993)2.98845332
47Muscle stiffness (HP:0003552)2.96693247
48Difficulty climbing stairs (HP:0003551)2.95189384
49Muscle fiber inclusion bodies (HP:0100299)2.95156497
50Dicarboxylic aciduria (HP:0003215)2.94746395
51Abnormality of dicarboxylic acid metabolism (HP:0010995)2.94746395
52Acute necrotizing encephalopathy (HP:0006965)2.91945843
53Increased muscle lipid content (HP:0009058)2.88265305
54Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.87941651
55Bulbar palsy (HP:0001283)2.87203818
56Hepatocellular necrosis (HP:0001404)2.81766920
57Frequent falls (HP:0002359)2.80487088
58Abnormal EKG (HP:0003115)2.80478498
59Left ventricular hypertrophy (HP:0001712)2.70125707
60Acute encephalopathy (HP:0006846)2.63808055
61Increased variability in muscle fiber diameter (HP:0003557)2.54194473
62Neck muscle weakness (HP:0000467)2.48810427
63Foot dorsiflexor weakness (HP:0009027)2.48768105
64Conjunctival hamartoma (HP:0100780)2.46108835
65Cerebral edema (HP:0002181)2.45759865
66Ketosis (HP:0001946)2.44888268
67Progressive macrocephaly (HP:0004481)2.42089728
68Palmoplantar keratoderma (HP:0000982)2.40563920
69Mitochondrial inheritance (HP:0001427)2.39592880
70Ragged-red muscle fibers (HP:0003200)2.38357141
71Distal lower limb muscle weakness (HP:0009053)2.37543361
72Abnormality of skeletal muscle fiber size (HP:0012084)2.37100602
73Areflexia of lower limbs (HP:0002522)2.36370038
74Scapular winging (HP:0003691)2.35189835
75Increased CSF lactate (HP:0002490)2.34114343
76Increased intramyocellular lipid droplets (HP:0012240)2.30096639
77Lactic acidosis (HP:0003128)2.27050341
78Nemaline bodies (HP:0003798)2.26736306
79Hyperglycinuria (HP:0003108)2.25705611
80Generalized muscle weakness (HP:0003324)2.25631391
81Hyperkalemia (HP:0002153)2.24096721
82Calcaneovalgus deformity (HP:0001848)2.23586362
83Exercise intolerance (HP:0003546)2.23252378
84Abnormality of alanine metabolism (HP:0010916)2.22165931
85Hyperalaninemia (HP:0003348)2.22165931
86Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.22165931
87Testicular atrophy (HP:0000029)2.16459600
88Waddling gait (HP:0002515)2.15900059
89Pheochromocytoma (HP:0002666)2.15574619
90Facial diplegia (HP:0001349)2.10776325
91Respiratory failure (HP:0002878)2.10442233
92Dysmetric saccades (HP:0000641)2.10167822
93Lower limb amyotrophy (HP:0007210)2.09237681
94Generalized aminoaciduria (HP:0002909)2.08427100
95Rimmed vacuoles (HP:0003805)2.07096625
96Hamartoma of the eye (HP:0010568)2.06145545
97EMG: neuropathic changes (HP:0003445)2.04719552
98Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.04661468
99Abnormality of the endocardium (HP:0004306)2.04176170
100Limb-girdle muscle atrophy (HP:0003797)2.03681863
101Progressive muscle weakness (HP:0003323)2.03071773
102Obstructive sleep apnea (HP:0002870)2.00015937
103Weak cry (HP:0001612)1.98501709
104Muscular dystrophy (HP:0003560)1.96518660
105Hyperammonemia (HP:0001987)1.96410533
106Hypoplastic ischia (HP:0003175)1.96201331
107Sudden cardiac death (HP:0001645)1.94829733
108Gowers sign (HP:0003391)1.94793700
109Abnormality of the foot musculature (HP:0001436)1.94529020
110Hyperinsulinemic hypoglycemia (HP:0000825)1.93615760
111Esophageal neoplasm (HP:0100751)1.92477078
112Neoplasm of head and neck (HP:0012288)1.92477078
113Colitis (HP:0002583)1.91777895
114Congestive heart failure (HP:0001635)1.91672761
115Neoplasm of the adrenal gland (HP:0100631)1.90682611
116Neuroendocrine neoplasm (HP:0100634)1.90382138
117Mildly elevated creatine phosphokinase (HP:0008180)1.90159785
118Malignant hyperthermia (HP:0002047)1.89381853
119Increased serum pyruvate (HP:0003542)1.86729891
120Abnormality of glycolysis (HP:0004366)1.86729891
121Progressive external ophthalmoplegia (HP:0000590)1.85338118
122Deformed tarsal bones (HP:0008119)1.84434180
123Absent phalangeal crease (HP:0006109)1.82524407
124Easy fatigability (HP:0003388)1.81873608
125Hip contracture (HP:0003273)1.80565342
126Proximal amyotrophy (HP:0007126)1.76205357
127Abnormality of the neuromuscular junction (HP:0003398)1.74811561
128Fatigable weakness (HP:0003473)1.74811561
129Chest pain (HP:0100749)1.69090771
130Abnormality of the shoulder girdle musculature (HP:0001435)1.62726216
131Steppage gait (HP:0003376)1.60903496
132Abnormality of the calcaneus (HP:0008364)1.59979121
133Fetal akinesia sequence (HP:0001989)1.55720847
134Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.55681388
135Abnormality of the ischium (HP:0003174)1.47762783
136Fatigue (HP:0012378)1.46199878
137Eczematoid dermatitis (HP:0000976)1.45920982
138Gastrointestinal stroma tumor (HP:0100723)1.45505400
139Metaphyseal cupping (HP:0003021)1.45453229
140Rapidly progressive (HP:0003678)1.41561728

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN5.31148636
2OBSCN4.90685288
3PDK44.85551700
4PDK34.85551700
5PHKG23.71831760
6PHKG13.71831760
7LMTK23.33509052
8MYLK3.09416098
9PDK23.04713321
10TRIB32.89163160
11BCKDK2.82923870
12PKN22.76501366
13DMPK2.60164961
14NEK12.10710495
15TNK22.07006179
16TIE11.94483051
17PIK3CA1.94407934
18PINK11.92406260
19MAP4K11.89464943
20STK241.82523988
21MUSK1.81137739
22BLK1.75726948
23MAPK151.74539226
24ICK1.71074739
25MAP3K61.69842498
26MAP3K131.57245050
27PRPF4B1.50841874
28RIPK41.30710446
29EEF2K1.26770349
30ERN11.23342374
31WNK41.22422647
32MAP2K31.17747297
33PRKD11.15295182
34GRK71.14127639
35ZAP701.11550382
36TBK11.11227467
37SIK21.10258539
38ILK1.06906468
39MAP3K71.04609049
40TYK21.03094014
41PAK31.03014766
42CAMK2D1.01821630
43FGFR41.00829424
44PRKAA11.00589200
45PRKAA20.99513935
46STK38L0.98142116
47MAP2K40.96638283
48MAPK70.96203703
49ZAK0.95758106
50DYRK1B0.95087588
51INSRR0.91308809
52PRKD30.91075652
53CSK0.89654355
54MAPK120.89163530
55MAP3K30.83593098
56MAP3K50.83131559
57ROCK10.81605519
58SYK0.79159004
59CDC42BPA0.78820947
60STK380.77362154
61IKBKE0.76918150
62STK40.75428441
63RIPK10.75104890
64KSR20.74800817
65MAP3K10.74282975
66TRPM70.73875363
67FLT30.73264780
68PTK2B0.71331788
69MARK30.69460873
70BTK0.69445725
71MAPKAPK30.68096068
72PKN10.67716262
73ITK0.66993149
74PRKD20.66318304
75JAK30.66083663
76SIK30.65019831
77STK390.63295436
78MAPK40.63271239
79CAMK1D0.63052802
80MARK10.62745267
81WNK10.59444790
82PDGFRA0.59420470
83HCK0.59305344
84IRAK40.58203396
85PDPK10.57167066
86CAMK40.56879723
87KIT0.56714985
88CSF1R0.56713507
89PDK10.56310372
90FES0.55746452
91RPS6KL10.55163124
92RPS6KC10.55163124
93MAP3K140.53868992
94CAMK1G0.53341200
95TGFBR20.53111571
96DAPK30.53096939
97CDK190.51249729
98SIK10.51227435
99STK110.50032501
100CAMK10.46450483
101RPS6KA60.46223195
102KDR0.45375622
103GRK60.45272042
104PTK60.43175359
105TAOK10.42699263
106NEK90.41811283
107JAK20.41393746
108PRKACB0.41277154
109PRKACG0.40814408
110CAMK2A0.40577683
111BMX0.40390028
112EPHB10.39320463
113ROCK20.37139966
114FGR0.36465806
115MAP2K20.35120984
116PIK3CG0.34314838
117AKT20.33704067
118PRKACA0.33497789
119NME10.33305807
120MTOR0.32063993
121LATS10.30142420
122RPS6KA10.28858757
123CAMK2G0.27846368
124MAPK110.27570910
125PRKCE0.27558968
126PRKCH0.24849287
127SGK30.21222169
128MAP3K110.19845203
129FGFR30.18579001
130EPHB20.18286578
131RET0.16068588
132MARK20.15708091
133LATS20.15555552
134PRKG10.14694840
135TAOK20.14269989
136JAK10.13460256
137RPS6KA30.13116438
138MAP2K60.12289776
139MAP3K100.11927892
140SGK10.11852141
141TESK10.11638290
142PDGFRB0.10384076
143PRKG20.09652581
144RPS6KA20.09197886

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.45119662
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.38347034
3Propanoate metabolism_Homo sapiens_hsa006404.09319597
4Cardiac muscle contraction_Homo sapiens_hsa042603.78777517
5* Fatty acid degradation_Homo sapiens_hsa000713.15059810
6Dilated cardiomyopathy_Homo sapiens_hsa054143.13548884
7Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.09747300
8Carbon metabolism_Homo sapiens_hsa012002.77425057
9Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.74783698
10Parkinsons disease_Homo sapiens_hsa050122.74761980
11Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.71007234
12Oxidative phosphorylation_Homo sapiens_hsa001902.65501784
13* Fatty acid metabolism_Homo sapiens_hsa012122.55134181
14Pyruvate metabolism_Homo sapiens_hsa006202.33319019
15Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.05240289
16Alzheimers disease_Homo sapiens_hsa050102.03065935
17Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.95575993
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.88589431
19Huntingtons disease_Homo sapiens_hsa050161.82850490
20Fatty acid elongation_Homo sapiens_hsa000621.69332490
21Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.57691695
22Butanoate metabolism_Homo sapiens_hsa006501.57260199
23B cell receptor signaling pathway_Homo sapiens_hsa046621.53004821
24* PPAR signaling pathway_Homo sapiens_hsa033201.48122024
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.47804957
26Fatty acid biosynthesis_Homo sapiens_hsa000611.46021358
27Notch signaling pathway_Homo sapiens_hsa043301.43663358
28Viral myocarditis_Homo sapiens_hsa054161.43037555
29Osteoclast differentiation_Homo sapiens_hsa043801.30873867
30Acute myeloid leukemia_Homo sapiens_hsa052211.28784981
31Other glycan degradation_Homo sapiens_hsa005111.27296191
32Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.24240548
33Biosynthesis of amino acids_Homo sapiens_hsa012301.24178500
34* Glucagon signaling pathway_Homo sapiens_hsa049221.17828801
35Leishmaniasis_Homo sapiens_hsa051401.12167747
36Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.09481710
37Starch and sucrose metabolism_Homo sapiens_hsa005001.05440791
38Insulin signaling pathway_Homo sapiens_hsa049101.03145091
39* Insulin resistance_Homo sapiens_hsa049311.02365147
40Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00152123
41Phospholipase D signaling pathway_Homo sapiens_hsa040720.97539455
42beta-Alanine metabolism_Homo sapiens_hsa004100.95043731
43* Adipocytokine signaling pathway_Homo sapiens_hsa049200.94887911
44Tryptophan metabolism_Homo sapiens_hsa003800.94009929
45MAPK signaling pathway_Homo sapiens_hsa040100.93610823
46Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.93347818
47Neurotrophin signaling pathway_Homo sapiens_hsa047220.91129462
48Lysine degradation_Homo sapiens_hsa003100.91096297
49T cell receptor signaling pathway_Homo sapiens_hsa046600.90630108
50cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90257785
51RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86035444
52Primary immunodeficiency_Homo sapiens_hsa053400.83998186
53Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.83756084
54Long-term potentiation_Homo sapiens_hsa047200.83524377
55Allograft rejection_Homo sapiens_hsa053300.80670979
56Non-small cell lung cancer_Homo sapiens_hsa052230.80332036
57* AMPK signaling pathway_Homo sapiens_hsa041520.79732587
58Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79720439
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.77496008
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.76739926
61Choline metabolism in cancer_Homo sapiens_hsa052310.74254419
62Inositol phosphate metabolism_Homo sapiens_hsa005620.74122160
63Autoimmune thyroid disease_Homo sapiens_hsa053200.73616630
64Peroxisome_Homo sapiens_hsa041460.72661589
65Prolactin signaling pathway_Homo sapiens_hsa049170.72348231
66Staphylococcus aureus infection_Homo sapiens_hsa051500.71214507
67Influenza A_Homo sapiens_hsa051640.69171335
68Cholinergic synapse_Homo sapiens_hsa047250.68757880
69Graft-versus-host disease_Homo sapiens_hsa053320.66762936
70Tuberculosis_Homo sapiens_hsa051520.66740650
71Estrogen signaling pathway_Homo sapiens_hsa049150.66189518
72Calcium signaling pathway_Homo sapiens_hsa040200.64571026
73Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.64437630
74HIF-1 signaling pathway_Homo sapiens_hsa040660.63984111
75Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.62578955
76Chemokine signaling pathway_Homo sapiens_hsa040620.62209897
77Jak-STAT signaling pathway_Homo sapiens_hsa046300.60372641
78Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59960902
79Chronic myeloid leukemia_Homo sapiens_hsa052200.59617428
80Fructose and mannose metabolism_Homo sapiens_hsa000510.59267297
81Arginine biosynthesis_Homo sapiens_hsa002200.57393372
82Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.56912035
83Galactose metabolism_Homo sapiens_hsa000520.56246642
84Focal adhesion_Homo sapiens_hsa045100.56124497
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55917089
86Endometrial cancer_Homo sapiens_hsa052130.55509738
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.55202356
88Type II diabetes mellitus_Homo sapiens_hsa049300.55200820
89NF-kappa B signaling pathway_Homo sapiens_hsa040640.55143989
90Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.54802833
91Regulation of autophagy_Homo sapiens_hsa041400.50682926
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.49701483
93Glycerolipid metabolism_Homo sapiens_hsa005610.49254682
94Oxytocin signaling pathway_Homo sapiens_hsa049210.48948354
95AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48441987
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.47771266
97Arginine and proline metabolism_Homo sapiens_hsa003300.47738839
98Measles_Homo sapiens_hsa051620.47318793
99Renin secretion_Homo sapiens_hsa049240.46511751
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.45417678
101Phenylalanine metabolism_Homo sapiens_hsa003600.45365138
102ErbB signaling pathway_Homo sapiens_hsa040120.45048549
103NOD-like receptor signaling pathway_Homo sapiens_hsa046210.44001233
104TNF signaling pathway_Homo sapiens_hsa046680.43646743
105Tight junction_Homo sapiens_hsa045300.43452997
106Hepatitis C_Homo sapiens_hsa051600.43395435
107Herpes simplex infection_Homo sapiens_hsa051680.41853265
108Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41061454
109Fat digestion and absorption_Homo sapiens_hsa049750.38035798
110ECM-receptor interaction_Homo sapiens_hsa045120.34546162
111Pentose phosphate pathway_Homo sapiens_hsa000300.31652011
112cAMP signaling pathway_Homo sapiens_hsa040240.30982570
113Metabolic pathways_Homo sapiens_hsa011000.30698710
114Gastric acid secretion_Homo sapiens_hsa049710.28289053
115Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.27793488
116Adherens junction_Homo sapiens_hsa045200.25924129
117Circadian rhythm_Homo sapiens_hsa047100.24577103
118Cysteine and methionine metabolism_Homo sapiens_hsa002700.24224172
119Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.23797747
120Insulin secretion_Homo sapiens_hsa049110.20698121
121mTOR signaling pathway_Homo sapiens_hsa041500.20412602
122Amoebiasis_Homo sapiens_hsa051460.18230923
123Dorso-ventral axis formation_Homo sapiens_hsa043200.16107274
124Tyrosine metabolism_Homo sapiens_hsa003500.15925560
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.13417423
126Bile secretion_Homo sapiens_hsa049760.09657761
127Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.09334547
128VEGF signaling pathway_Homo sapiens_hsa043700.07842030
129ABC transporters_Homo sapiens_hsa020100.07324745
130Circadian entrainment_Homo sapiens_hsa047130.07059989
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.06906772
132Ovarian steroidogenesis_Homo sapiens_hsa049130.06291102
133Proteoglycans in cancer_Homo sapiens_hsa052050.05653553
134Leukocyte transendothelial migration_Homo sapiens_hsa046700.05598757
135Regulation of actin cytoskeleton_Homo sapiens_hsa048100.05184171
136Platelet activation_Homo sapiens_hsa046110.03857071
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.03349848
138Renal cell carcinoma_Homo sapiens_hsa052110.02623757
139Pancreatic secretion_Homo sapiens_hsa049720.01405552
140FoxO signaling pathway_Homo sapiens_hsa040680.01048209
141Toxoplasmosis_Homo sapiens_hsa051450.00382460
142Small cell lung cancer_Homo sapiens_hsa05222-0.0396098
143Protein digestion and absorption_Homo sapiens_hsa04974-0.0337786
144Carbohydrate digestion and absorption_Homo sapiens_hsa04973-0.0214217
145alpha-Linolenic acid metabolism_Homo sapiens_hsa00592-0.0145201
146GnRH signaling pathway_Homo sapiens_hsa04912-0.0128326

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