CPT1C

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the carnitine/choline acetyltransferase family. The encoded protein regulates the beta-oxidation and transport of long-chain fatty acids into mitochondria, and may play a role in the regulation of feeding behavior and whole-body energy homeostasis. Alternatively spliced transcript variants encoding multiple protein isoforms have been observed for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.84991326
2synaptic vesicle maturation (GO:0016188)5.39993183
3vocalization behavior (GO:0071625)5.35234616
4synaptic vesicle exocytosis (GO:0016079)5.34636369
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.31907034
6regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.22139854
7locomotory exploration behavior (GO:0035641)5.09451576
8positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.98341090
9behavioral response to nicotine (GO:0035095)4.97763053
10glutamate secretion (GO:0014047)4.92296069
11synaptic vesicle docking involved in exocytosis (GO:0016081)4.87619126
12regulation of synaptic vesicle exocytosis (GO:2000300)4.83873660
13pyrimidine nucleobase catabolic process (GO:0006208)4.83004042
14protein localization to synapse (GO:0035418)4.82789313
15regulation of glutamate receptor signaling pathway (GO:1900449)4.80993042
16neuron cell-cell adhesion (GO:0007158)4.79893679
17ionotropic glutamate receptor signaling pathway (GO:0035235)4.49684688
18neurotransmitter-gated ion channel clustering (GO:0072578)4.30193878
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.26728770
20regulation of synaptic vesicle transport (GO:1902803)4.24454162
21neurotransmitter secretion (GO:0007269)4.23779686
22exploration behavior (GO:0035640)4.22824596
23synaptic transmission, glutamatergic (GO:0035249)4.19292002
24glutamate receptor signaling pathway (GO:0007215)4.16978933
25positive regulation of synapse maturation (GO:0090129)4.16585124
26neuronal action potential propagation (GO:0019227)4.12374320
27regulation of neuronal synaptic plasticity (GO:0048168)4.12229247
28regulation of long-term neuronal synaptic plasticity (GO:0048169)4.02908286
29neuron-neuron synaptic transmission (GO:0007270)3.99185798
30nucleobase catabolic process (GO:0046113)3.88377823
31regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.87072422
32regulation of synapse structural plasticity (GO:0051823)3.85420219
33membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.71255264
34regulation of excitatory postsynaptic membrane potential (GO:0060079)3.69320424
35negative regulation of synaptic transmission, GABAergic (GO:0032229)3.67392780
36neuron recognition (GO:0008038)3.67086127
37long-term synaptic potentiation (GO:0060291)3.66613233
38postsynaptic membrane organization (GO:0001941)3.65149386
39synaptic vesicle endocytosis (GO:0048488)3.63340035
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.62621874
41layer formation in cerebral cortex (GO:0021819)3.60699657
42positive regulation of membrane potential (GO:0045838)3.57239287
43dendritic spine morphogenesis (GO:0060997)3.53317083
44regulation of postsynaptic membrane potential (GO:0060078)3.52817340
45regulation of synaptic transmission, glutamatergic (GO:0051966)3.51760037
46gamma-aminobutyric acid transport (GO:0015812)3.50867578
47long-term memory (GO:0007616)3.50597183
48negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.49043928
49nonmotile primary cilium assembly (GO:0035058)3.48952826
50G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.48605329
51positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.47738309
52regulation of synaptic plasticity (GO:0048167)3.47290132
53neurotransmitter transport (GO:0006836)3.43906693
54transmission of nerve impulse (GO:0019226)3.43323598
55presynaptic membrane assembly (GO:0097105)3.41234507
56axonal fasciculation (GO:0007413)3.38263114
57cellular potassium ion homeostasis (GO:0030007)3.37081442
58innervation (GO:0060384)3.34826911
59regulation of neurotransmitter secretion (GO:0046928)3.30390435
60positive regulation of synaptic transmission, GABAergic (GO:0032230)3.28353863
61regulation of dendritic spine morphogenesis (GO:0061001)3.27036961
62cerebellar granule cell differentiation (GO:0021707)3.26681778
63proline transport (GO:0015824)3.25974589
64presynaptic membrane organization (GO:0097090)3.23217140
65membrane hyperpolarization (GO:0060081)3.22530386
66regulation of synapse maturation (GO:0090128)3.20361344
67regulation of vesicle fusion (GO:0031338)3.19687755
68auditory behavior (GO:0031223)3.19658652
69membrane depolarization during action potential (GO:0086010)3.18687211
70neuromuscular process controlling balance (GO:0050885)3.17151555
71cerebellar Purkinje cell differentiation (GO:0021702)3.15354979
72regulation of neurotransmitter levels (GO:0001505)3.14157939
73membrane depolarization (GO:0051899)3.13035123
74regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10905623
75regulation of neurotransmitter transport (GO:0051588)3.09546532
76sodium ion export (GO:0071436)3.08916230
77behavioral fear response (GO:0001662)3.06525996
78behavioral defense response (GO:0002209)3.06525996
79spinal cord development (GO:0021510)3.03293390
80cell migration in hindbrain (GO:0021535)3.03011665
81response to auditory stimulus (GO:0010996)3.02305951
82protein polyglutamylation (GO:0018095)3.01067574
83learning (GO:0007612)3.00834879
84synapse assembly (GO:0007416)2.99948683
85cell communication by electrical coupling (GO:0010644)2.99857884
86retinal ganglion cell axon guidance (GO:0031290)2.97109625
87positive regulation of synapse assembly (GO:0051965)2.96832105
88cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.96415360
89positive regulation of synaptic transmission (GO:0050806)2.96005801
90dendrite morphogenesis (GO:0048813)2.95846850
91neuromuscular synaptic transmission (GO:0007274)2.95827243
92establishment of mitochondrion localization (GO:0051654)2.95512569
93response to histamine (GO:0034776)2.94789219
94regulation of synaptic transmission (GO:0050804)2.94568193
95neuronal ion channel clustering (GO:0045161)2.94478971
96mechanosensory behavior (GO:0007638)2.93686237
97activation of protein kinase A activity (GO:0034199)2.92925177
98positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.92379977
99positive regulation of neurotransmitter secretion (GO:0001956)2.92275626
100positive regulation of neurotransmitter transport (GO:0051590)2.92165530
101neuromuscular process controlling posture (GO:0050884)2.91010338
102regulation of glutamate secretion (GO:0014048)2.90803188
103synaptic transmission (GO:0007268)2.90714544
104calcium ion-dependent exocytosis (GO:0017156)2.89688319
105prepulse inhibition (GO:0060134)2.88579716
106dendritic spine organization (GO:0097061)2.88202385
107regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.87194145
108startle response (GO:0001964)2.86777487
109axon ensheathment in central nervous system (GO:0032291)2.85950342
110central nervous system myelination (GO:0022010)2.85950342
111fear response (GO:0042596)2.85785257
112positive regulation of dendritic spine morphogenesis (GO:0061003)2.85496115
113behavioral response to ethanol (GO:0048149)2.83526554
114negative regulation of cytosolic calcium ion concentration (GO:0051481)2.82258667
115head development (GO:0060322)2.78375605
116calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.75105081
117regulation of respiratory system process (GO:0044065)2.74325860
118retinal cone cell development (GO:0046549)2.72186341
119regulation of neurotransmitter uptake (GO:0051580)2.68799973
120synaptic transmission, cholinergic (GO:0007271)2.63820374
121somite development (GO:0061053)2.62342407
122epithelial cilium movement (GO:0003351)2.61086808
123epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.59403867
124synapse organization (GO:0050808)2.56459992
125central nervous system projection neuron axonogenesis (GO:0021952)2.53028448
126limb bud formation (GO:0060174)2.52147655
127detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.52143590
128regulation of respiratory gaseous exchange (GO:0043576)2.50076879
129C4-dicarboxylate transport (GO:0015740)2.47990395
130negative regulation of transcription regulatory region DNA binding (GO:2000678)2.47587748
131cell proliferation in forebrain (GO:0021846)2.45863372
132adult walking behavior (GO:0007628)2.44625240
133negative regulation of axon guidance (GO:1902668)2.44465757
134negative regulation of oligodendrocyte differentiation (GO:0048715)2.41230471
135glycosphingolipid biosynthetic process (GO:0006688)2.41081630
136regulation of cilium movement (GO:0003352)2.38445763
137inner ear receptor stereocilium organization (GO:0060122)2.38030196
138adult behavior (GO:0030534)2.37538226
139short-term memory (GO:0007614)2.37419827
140negative regulation of axon extension (GO:0030517)2.37170154
141primary amino compound metabolic process (GO:1901160)2.36336005
142regulation of synapse assembly (GO:0051963)2.36333417
143substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.33947907
144substrate-independent telencephalic tangential migration (GO:0021826)2.33947907
145cerebral cortex radially oriented cell migration (GO:0021799)2.33937429

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.73038598
2GBX2_23144817_ChIP-Seq_PC3_Human3.77793305
3SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.08512372
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.93930675
5JARID2_20064375_ChIP-Seq_MESCs_Mouse2.90456775
6REST_21632747_ChIP-Seq_MESCs_Mouse2.78467824
7RNF2_18974828_ChIP-Seq_MESCs_Mouse2.62822592
8EZH2_18974828_ChIP-Seq_MESCs_Mouse2.62822592
9* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.62440769
10EZH2_27304074_Chip-Seq_ESCs_Mouse2.59212395
11* RARB_27405468_Chip-Seq_BRAIN_Mouse2.54474367
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.52872950
13ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.51855272
14SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50503142
15SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.41608915
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.41411844
17MTF2_20144788_ChIP-Seq_MESCs_Mouse2.37774720
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.36525853
19CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.30835862
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.30720271
21REST_18959480_ChIP-ChIP_MESCs_Mouse2.30450584
22GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.26854188
23* DROSHA_22980978_ChIP-Seq_HELA_Human2.25442657
24EZH2_27294783_Chip-Seq_ESCs_Mouse2.23865988
25RNF2_27304074_Chip-Seq_ESCs_Mouse2.21226667
26SUZ12_27294783_Chip-Seq_ESCs_Mouse2.20561328
27IKZF1_21737484_ChIP-ChIP_HCT116_Human2.14795356
28CTBP2_25329375_ChIP-Seq_LNCAP_Human1.96605707
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.86190875
30MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.83936868
31CTBP1_25329375_ChIP-Seq_LNCAP_Human1.79120338
32TAF15_26573619_Chip-Seq_HEK293_Human1.63034226
33SMAD4_21799915_ChIP-Seq_A2780_Human1.60230492
34AR_21572438_ChIP-Seq_LNCaP_Human1.59456321
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.58464247
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.55170196
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.54524587
38ZNF274_21170338_ChIP-Seq_K562_Hela1.52558919
39GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45139497
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.44332799
41CBX2_27304074_Chip-Seq_ESCs_Mouse1.43746189
42ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43011883
43PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.42278952
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.42120258
45TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41523047
46POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41523047
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.40496368
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.37948721
49RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37338019
50RING1B_27294783_Chip-Seq_ESCs_Mouse1.35379521
51P300_19829295_ChIP-Seq_ESCs_Human1.34547750
52SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.34433093
53RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34118287
54SMAD3_21741376_ChIP-Seq_EPCs_Human1.31960663
55MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30797541
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.30778876
57EWS_26573619_Chip-Seq_HEK293_Human1.29034258
58RNF2_27304074_Chip-Seq_NSC_Mouse1.26082789
59KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.25638160
60* SOX2_21211035_ChIP-Seq_LN229_Gbm1.25636544
61RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22687062
62AR_25329375_ChIP-Seq_VCAP_Human1.18689229
63TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18004904
64AR_19668381_ChIP-Seq_PC3_Human1.17884513
65* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.17864217
66SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.17809227
67NR3C1_23031785_ChIP-Seq_PC12_Mouse1.14813163
68FLI1_27457419_Chip-Seq_LIVER_Mouse1.14681502
69RING1B_27294783_Chip-Seq_NPCs_Mouse1.14474245
70IRF1_19129219_ChIP-ChIP_H3396_Human1.14420733
71OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13871607
72CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.13764394
73TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13741803
74DNAJC2_21179169_ChIP-ChIP_NT2_Human1.13240127
75STAT3_23295773_ChIP-Seq_U87_Human1.13209131
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.10756537
77FUS_26573619_Chip-Seq_HEK293_Human1.09675638
78MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.08286595
79TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.08076362
80IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.07084190
81CBP_20019798_ChIP-Seq_JUKART_Human1.07084190
82MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.06755175
83YAP1_20516196_ChIP-Seq_MESCs_Mouse1.06572855
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06561593
85WT1_25993318_ChIP-Seq_PODOCYTE_Human1.05887654
86GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05110212
87GATA1_26923725_Chip-Seq_HPCs_Mouse1.04478409
88SALL1_21062744_ChIP-ChIP_HESCs_Human1.04316100
89IGF1R_20145208_ChIP-Seq_DFB_Human1.03700380
90TCF4_23295773_ChIP-Seq_U87_Human1.03270722
91FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.03249391
92RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.03243131
93SOX2_16153702_ChIP-ChIP_HESCs_Human1.02918050
94WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02831848
95PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.02180504
96ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00865630
97NR3C1_21868756_ChIP-Seq_MCF10A_Human1.00823097
98CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00463457
99VDR_22108803_ChIP-Seq_LS180_Human0.99945062
100SMAD3_21741376_ChIP-Seq_ESCs_Human0.98993834
101TP53_22573176_ChIP-Seq_HFKS_Human0.98674136
102* TP53_20018659_ChIP-ChIP_R1E_Mouse0.97558269
103BCAT_22108803_ChIP-Seq_LS180_Human0.97133100
104CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.96767147
105PCGF2_27294783_Chip-Seq_NPCs_Mouse0.96663576
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.96038737
107PCGF2_27294783_Chip-Seq_ESCs_Mouse0.96013963
108ETV2_25802403_ChIP-Seq_MESCs_Mouse0.95715508
109ARNT_22903824_ChIP-Seq_MCF-7_Human0.95380389
110JUN_21703547_ChIP-Seq_K562_Human0.95008164
111ER_23166858_ChIP-Seq_MCF-7_Human0.94384943
112MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93872650
113EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.92916689
114TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.92566849
115SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92259358
116SOX9_26525672_Chip-Seq_HEART_Mouse0.92055481
117RUNX2_22187159_ChIP-Seq_PCA_Human0.90772090
118ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.89650672
119POU3F2_20337985_ChIP-ChIP_501MEL_Human0.89331508
120SMAD_19615063_ChIP-ChIP_OVARY_Human0.89059092
121UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.88991882
122AHR_22903824_ChIP-Seq_MCF-7_Human0.88871735
123TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.88687533
124TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88575726
125OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.88088019
126PRDM14_20953172_ChIP-Seq_ESCs_Human0.87455702
127ZNF217_24962896_ChIP-Seq_MCF-7_Human0.85843902
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.85461653
129SMAD3_21741376_ChIP-Seq_HESCs_Human0.85258455
130TET1_21490601_ChIP-Seq_MESCs_Mouse0.85034423
131SMAD4_21741376_ChIP-Seq_HESCs_Human0.84760867
132TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84568788

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.86968666
2MP0003880_abnormal_central_pattern4.80433939
3MP0003635_abnormal_synaptic_transmissio3.85983254
4MP0004270_analgesia3.26994843
5MP0009745_abnormal_behavioral_response3.19414912
6MP0002063_abnormal_learning/memory/cond3.09995906
7MP0009046_muscle_twitch3.04624537
8MP0002064_seizures3.01523617
9MP0001968_abnormal_touch/_nociception2.85175309
10MP0002572_abnormal_emotion/affect_behav2.65944137
11MP0002272_abnormal_nervous_system2.47863108
12MP0002822_catalepsy2.45033434
13MP0002734_abnormal_mechanical_nocicepti2.44901308
14MP0005423_abnormal_somatic_nervous2.43500132
15MP0002736_abnormal_nociception_after2.37920654
16MP0001486_abnormal_startle_reflex2.35931687
17MP0006292_abnormal_olfactory_placode2.28541744
18MP0002735_abnormal_chemical_nociception2.10331514
19MP0001501_abnormal_sleep_pattern2.08696777
20MP0004858_abnormal_nervous_system1.96587684
21MP0001440_abnormal_grooming_behavior1.93722551
22MP0000778_abnormal_nervous_system1.87465277
23MP0002067_abnormal_sensory_capabilities1.85799343
24MP0002733_abnormal_thermal_nociception1.85511539
25MP0002184_abnormal_innervation1.85138978
26MP0003122_maternal_imprinting1.82788002
27MP0001970_abnormal_pain_threshold1.77103152
28MP0003136_yellow_coat_color1.75284361
29MP0009780_abnormal_chondrocyte_physiolo1.73408639
30MP0002557_abnormal_social/conspecific_i1.70117245
31MP0004811_abnormal_neuron_physiology1.70050640
32MP0001984_abnormal_olfaction1.67832481
33MP0003787_abnormal_imprinting1.66450140
34MP0008569_lethality_at_weaning1.65969817
35MP0006276_abnormal_autonomic_nervous1.65654791
36MP0003329_amyloid_beta_deposits1.64141391
37MP0002102_abnormal_ear_morphology1.58363278
38MP0000955_abnormal_spinal_cord1.58294828
39MP0005646_abnormal_pituitary_gland1.57492446
40MP0001529_abnormal_vocalization1.57076956
41MP0004924_abnormal_behavior1.54957715
42MP0005386_behavior/neurological_phenoty1.54957715
43MP0008789_abnormal_olfactory_epithelium1.53277966
44MP0002882_abnormal_neuron_morphology1.46019860
45MP0002653_abnormal_ependyma_morphology1.45615281
46MP0005645_abnormal_hypothalamus_physiol1.42331310
47MP0010030_abnormal_orbit_morphology1.39875682
48MP0000049_abnormal_middle_ear1.39453446
49MP0003879_abnormal_hair_cell1.38852822
50MP0002938_white_spotting1.37801039
51MP0001502_abnormal_circadian_rhythm1.35867496
52MP0002066_abnormal_motor_capabilities/c1.34208008
53MP0004885_abnormal_endolymph1.33997552
54MP0002909_abnormal_adrenal_gland1.31469628
55MP0001188_hyperpigmentation1.28656720
56MP0001905_abnormal_dopamine_level1.25202695
57MP0004142_abnormal_muscle_tone1.24948040
58MP0005623_abnormal_meninges_morphology1.23907796
59MP0003119_abnormal_digestive_system1.20556924
60MP0002152_abnormal_brain_morphology1.19813492
61MP0005253_abnormal_eye_physiology1.19448385
62MP0001986_abnormal_taste_sensitivity1.15864277
63MP0005551_abnormal_eye_electrophysiolog1.12949947
64MP0000566_synostosis1.10705008
65MP0003283_abnormal_digestive_organ1.10221218
66MP0004233_abnormal_muscle_weight1.09320033
67MP0005410_abnormal_fertilization1.04955559
68MP0004145_abnormal_muscle_electrophysio1.03973083
69MP0003633_abnormal_nervous_system1.03394882
70MP0000751_myopathy1.01610963
71MP0003878_abnormal_ear_physiology1.01523109
72MP0005377_hearing/vestibular/ear_phenot1.01523109
73MP0003938_abnormal_ear_development1.01513096
74MP0003631_nervous_system_phenotype0.98855969
75MP0001293_anophthalmia0.98058037
76MP0000013_abnormal_adipose_tissue0.96397876
77MP0005195_abnormal_posterior_eye0.95416313
78MP0004147_increased_porphyrin_level0.94065102
79MP0003634_abnormal_glial_cell0.93229391
80MP0002229_neurodegeneration0.93058788
81MP0005394_taste/olfaction_phenotype0.92376810
82MP0005499_abnormal_olfactory_system0.92376810
83MP0000631_abnormal_neuroendocrine_gland0.91733522
84MP0003937_abnormal_limbs/digits/tail_de0.91426843
85MP0002752_abnormal_somatic_nervous0.89761817
86MP0010386_abnormal_urinary_bladder0.88938652
87MP0004742_abnormal_vestibular_system0.88776453
88MP0003632_abnormal_nervous_system0.87806304
89MP0003121_genomic_imprinting0.87752181
90MP0002090_abnormal_vision0.87711705
91MP0002233_abnormal_nose_morphology0.87405600
92MP0002234_abnormal_pharynx_morphology0.87136870
93* MP0002069_abnormal_eating/drinking_beha0.86619537
94MP0006072_abnormal_retinal_apoptosis0.86211985
95MP0003890_abnormal_embryonic-extraembry0.85398668
96MP0003123_paternal_imprinting0.83799693
97MP0001963_abnormal_hearing_physiology0.83544225
98MP0003755_abnormal_palate_morphology0.82496176
99MP0001346_abnormal_lacrimal_gland0.82154081
100MP0003011_delayed_dark_adaptation0.81385409
101MP0001177_atelectasis0.80650746
102MP0009379_abnormal_foot_pigmentation0.80480515
103MP0003861_abnormal_nervous_system0.79868096
104MP0008877_abnormal_DNA_methylation0.78138250
105MP0008872_abnormal_physiological_respon0.77855922
106MP0000569_abnormal_digit_pigmentation0.76958338
107MP0001299_abnormal_eye_distance/0.76929192
108MP0004085_abnormal_heartbeat0.76294631
109MP0003942_abnormal_urinary_system0.73416885
110MP0005391_vision/eye_phenotype0.73051211
111MP0003385_abnormal_body_wall0.72842085
112MP0001485_abnormal_pinna_reflex0.71244833
113MP0005171_absent_coat_pigmentation0.70402671
114MP0000534_abnormal_ureter_morphology0.69401669
115MP0002751_abnormal_autonomic_nervous0.69116290
116MP0002837_dystrophic_cardiac_calcinosis0.68751897
117MP0001664_abnormal_digestion0.67801958
118MP0002638_abnormal_pupillary_reflex0.64484100
119MP0003698_abnormal_male_reproductive0.63436563
120MP0008874_decreased_physiological_sensi0.61506876
121MP0001943_abnormal_respiration0.60807116
122MP0000920_abnormal_myelination0.60742486
123MP0003137_abnormal_impulse_conducting0.59340900
124MP0004133_heterotaxia0.59036828
125MP0000026_abnormal_inner_ear0.58533664
126MP0004215_abnormal_myocardial_fiber0.58463559
127MP0010769_abnormal_survival0.55595083
128MP0000604_amyloidosis0.55373691

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.81919975
2Myokymia (HP:0002411)5.78632356
3Focal seizures (HP:0007359)5.04280221
4Epileptic encephalopathy (HP:0200134)4.92286592
5Atonic seizures (HP:0010819)4.49774825
6Visual hallucinations (HP:0002367)4.34287111
7Febrile seizures (HP:0002373)3.97800345
8Progressive cerebellar ataxia (HP:0002073)3.82639874
9Absence seizures (HP:0002121)3.74362824
10Type II lissencephaly (HP:0007260)3.63809990
11Molar tooth sign on MRI (HP:0002419)3.43349425
12Abnormality of midbrain morphology (HP:0002418)3.43349425
13Dialeptic seizures (HP:0011146)3.39907400
14Generalized tonic-clonic seizures (HP:0002069)3.23288650
15Pancreatic fibrosis (HP:0100732)3.21502525
16Nephronophthisis (HP:0000090)3.21304395
17Supranuclear gaze palsy (HP:0000605)3.15488150
18Pancreatic cysts (HP:0001737)3.14476883
19True hermaphroditism (HP:0010459)3.13718093
20Cerebellar dysplasia (HP:0007033)3.10426823
21Amblyopia (HP:0000646)3.04574976
22Dysdiadochokinesis (HP:0002075)3.04194554
23Action tremor (HP:0002345)2.97760248
24Hyperventilation (HP:0002883)2.92724703
25Ankle clonus (HP:0011448)2.90856005
26Gaze-evoked nystagmus (HP:0000640)2.89049287
27Impaired vibration sensation in the lower limbs (HP:0002166)2.87727218
28Broad-based gait (HP:0002136)2.85124312
29Abnormality of the lower motor neuron (HP:0002366)2.77656896
30Lissencephaly (HP:0001339)2.74079687
31Abnormal eating behavior (HP:0100738)2.72790084
32Depression (HP:0000716)2.71606130
33Congenital stationary night blindness (HP:0007642)2.71472361
34Hemiparesis (HP:0001269)2.71270569
35Truncal ataxia (HP:0002078)2.69908901
36Dysmetria (HP:0001310)2.59079084
37Abnormality of the renal medulla (HP:0100957)2.55783947
38Poor eye contact (HP:0000817)2.49163044
39Cerebral inclusion bodies (HP:0100314)2.48202153
40Optic nerve hypoplasia (HP:0000609)2.45767560
41Impaired smooth pursuit (HP:0007772)2.43557185
42Epileptiform EEG discharges (HP:0011182)2.43474514
43Anxiety (HP:0000739)2.43251156
44Chronic hepatic failure (HP:0100626)2.41334520
45Septo-optic dysplasia (HP:0100842)2.39662676
46Urinary bladder sphincter dysfunction (HP:0002839)2.38228495
47Neurofibrillary tangles (HP:0002185)2.37728018
48Vaginal atresia (HP:0000148)2.34960435
49Excessive salivation (HP:0003781)2.34094226
50Drooling (HP:0002307)2.34094226
51Genital tract atresia (HP:0001827)2.33592084
52Cystic liver disease (HP:0006706)2.31531884
53Postural instability (HP:0002172)2.30045383
54EEG with generalized epileptiform discharges (HP:0011198)2.29416209
55Scanning speech (HP:0002168)2.28790801
56Sclerocornea (HP:0000647)2.27303470
57Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.26645037
58Spastic gait (HP:0002064)2.26058030
59Abnormal social behavior (HP:0012433)2.24664951
60Impaired social interactions (HP:0000735)2.24664951
61Genetic anticipation (HP:0003743)2.24659379
62Occipital encephalocele (HP:0002085)2.24014211
63Polyphagia (HP:0002591)2.23868325
64Inability to walk (HP:0002540)2.23232590
65Megalencephaly (HP:0001355)2.22452103
66Abnormality of the labia minora (HP:0012880)2.18823536
67Abnormality of binocular vision (HP:0011514)2.17147955
68Diplopia (HP:0000651)2.17147955
69Pheochromocytoma (HP:0002666)2.17076354
70Abnormality of ocular smooth pursuit (HP:0000617)2.15022666
71Pachygyria (HP:0001302)2.14177911
72Limb dystonia (HP:0002451)2.14008105
73Rib fusion (HP:0000902)2.13683346
74Abnormality of the corticospinal tract (HP:0002492)2.13630740
75Hypsarrhythmia (HP:0002521)2.13219622
76Anophthalmia (HP:0000528)2.10958018
77Bradykinesia (HP:0002067)2.10850667
78Hypoventilation (HP:0002791)2.09668789
79Absent speech (HP:0001344)2.09500673
80Anencephaly (HP:0002323)2.09433140
81Abolished electroretinogram (ERG) (HP:0000550)2.08720647
82Torticollis (HP:0000473)2.08186746
83Urinary urgency (HP:0000012)2.08111828
84Narrow nasal bridge (HP:0000446)2.07826716
85Gait imbalance (HP:0002141)2.07508440
86Hemiplegia (HP:0002301)2.06889917
87Severe muscular hypotonia (HP:0006829)2.06509862
88Mutism (HP:0002300)2.06046944
89Insidious onset (HP:0003587)2.01372634
90Termporal pattern (HP:0011008)2.01372634
91Failure to thrive in infancy (HP:0001531)2.01148387
92Lower limb muscle weakness (HP:0007340)1.99778180
93Patellar aplasia (HP:0006443)1.99308731
94Absent/shortened dynein arms (HP:0200106)1.99003432
95Dynein arm defect of respiratory motile cilia (HP:0012255)1.99003432
96Delusions (HP:0000746)1.96161365
97Progressive inability to walk (HP:0002505)1.94879130
98Intestinal atresia (HP:0011100)1.94779294
99Focal dystonia (HP:0004373)1.94315035
100Specific learning disability (HP:0001328)1.93844123
101Postaxial hand polydactyly (HP:0001162)1.93127613
102Colon cancer (HP:0003003)1.91954634
103Pendular nystagmus (HP:0012043)1.90950379
104Aplasia/Hypoplasia of the patella (HP:0006498)1.90000084
105Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.89509772
106Pointed chin (HP:0000307)1.86021114
107Neuroendocrine neoplasm (HP:0100634)1.85076953
108Retinal dysplasia (HP:0007973)1.84295790
109Fetal akinesia sequence (HP:0001989)1.84113607
110Gait ataxia (HP:0002066)1.84095996
111Impaired vibratory sensation (HP:0002495)1.83571980
112Polydipsia (HP:0001959)1.83498399
113Abnormal drinking behavior (HP:0030082)1.83498399
114Stereotypic behavior (HP:0000733)1.83058902
115Acute necrotizing encephalopathy (HP:0006965)1.82354628
116Intention tremor (HP:0002080)1.82229876
117Anterior segment dysgenesis (HP:0007700)1.81484279
118Hypoplasia of the pons (HP:0012110)1.80439232
119Narrow forehead (HP:0000341)1.80248125
120Tubular atrophy (HP:0000092)1.79936640
121Keratoconus (HP:0000563)1.79578724
122Increased corneal curvature (HP:0100692)1.79578724
123Congenital primary aphakia (HP:0007707)1.78245327
124Agitation (HP:0000713)1.76966737
125Postaxial foot polydactyly (HP:0001830)1.76045766
126Dysmetric saccades (HP:0000641)1.75957420
127Preaxial hand polydactyly (HP:0001177)1.75870220
128Incomplete penetrance (HP:0003829)1.75823284
129Generalized myoclonic seizures (HP:0002123)1.75240781
130Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.73806762
131Cutaneous finger syndactyly (HP:0010554)1.73111492
132Medial flaring of the eyebrow (HP:0010747)1.72559104
133Broad foot (HP:0001769)1.71897099
134Annular pancreas (HP:0001734)1.71877292
135Hepatoblastoma (HP:0002884)1.71572141
136Sleep apnea (HP:0010535)1.71403102
137Neoplasm of the heart (HP:0100544)1.71379577
138Aplasia involving bones of the upper limbs (HP:0009823)1.71163262
139Aplasia of the phalanges of the hand (HP:0009802)1.71163262
140Aplasia involving bones of the extremities (HP:0009825)1.71163262
141Poor coordination (HP:0002370)1.70638860
142Hypoplasia of the brainstem (HP:0002365)1.70604432
143Aplasia/Hypoplasia of the brainstem (HP:0007362)1.70604432
144Degeneration of the lateral corticospinal tracts (HP:0002314)1.69858486
145Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.69858486
146Supernumerary spleens (HP:0009799)1.69766405
147Craniofacial dystonia (HP:0012179)1.68714055
148Dandy-Walker malformation (HP:0001305)1.67795690
149Retinal atrophy (HP:0001105)1.67492442
150Abnormality of the pons (HP:0007361)1.65920592
151Aplasia/Hypoplasia of the spleen (HP:0010451)1.65335746
152Aplasia/Hypoplasia of the tibia (HP:0005772)1.65309084
153Aplasia/Hypoplasia of the tongue (HP:0010295)1.65162876
154Insomnia (HP:0100785)1.65083853
155Nephrogenic diabetes insipidus (HP:0009806)1.65057754
156Abnormality of the phalanges of the 2nd finger (HP:0009541)1.64188291
157Resting tremor (HP:0002322)1.63657177
158Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.63465482
159Short 4th metacarpal (HP:0010044)1.63465482
160Status epilepticus (HP:0002133)1.62546929
161Shoulder girdle muscle weakness (HP:0003547)1.62490488
162Hyperglycinemia (HP:0002154)1.62453375
163Attenuation of retinal blood vessels (HP:0007843)1.62144932

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.27569194
2NTRK34.26081100
3MAP3K93.62574094
4CASK3.03509091
5MAP3K42.91251438
6MINK12.61318497
7MARK12.45800381
8FRK2.44530639
9DYRK22.28295337
10PAK62.25957004
11MAP2K72.25781719
12DAPK22.18725965
13PRKD32.13287299
14ADRBK22.11389459
15NTRK22.11357381
16PRPF4B2.10864527
17MAP4K22.07207308
18ARAF1.96417081
19GRK11.87574317
20KSR21.86645972
21MAP3K121.81634058
22PLK21.78242843
23NTRK11.75298400
24BMPR1B1.66751960
25KSR11.65454879
26PNCK1.61736239
27TIE11.60357108
28MAP2K41.53914092
29DAPK11.52832402
30FGFR21.52365379
31WNK41.52213385
32TRIM281.47535624
33CDK191.45668868
34CDK51.43156779
35ZAK1.42811845
36INSRR1.41482653
37TNIK1.36566469
38STK381.28224939
39CAMKK11.27244431
40NUAK11.25649874
41GRK51.23881084
42PRKCG1.23095999
43MAP3K131.22673609
44PTK2B1.22423442
45CSNK1G31.22098757
46MAPK131.18218681
47TYRO31.17959457
48MKNK21.14064987
49RIPK41.13471974
50CDK181.11681018
51CSNK1G11.10743593
52UHMK11.10261411
53CDK141.09259930
54AKT31.09123736
55CDK151.08032286
56SIK21.07951364
57LATS21.04919233
58CSNK1A1L1.04328332
59EPHB21.03697821
60CAMK2A1.01745078
61PAK30.96432398
62PHKG10.96355044
63PHKG20.96355044
64SGK4940.95570425
65SGK2230.95570425
66CDK11A0.94225821
67BCKDK0.93321319
68PKN10.87750808
69CAMK2B0.86639233
70BRAF0.85453333
71OXSR10.84295067
72ADRBK10.80226494
73PDK30.79987376
74PDK40.79987376
75MAPK150.79493023
76LMTK20.77846768
77CCNB10.76048197
78CAMK10.74941702
79TLK10.73534835
80MAP3K20.72481979
81DYRK1A0.72255916
82RAF10.71975715
83FER0.71721071
84DDR20.70406439
85BCR0.69644571
86NEK10.69508659
87FES0.68036711
88CAMKK20.66803755
89SGK20.66723083
90MKNK10.65386649
91DYRK30.62188087
92DAPK30.61766141
93SIK30.61739816
94NEK60.60305336
95ROCK20.58990145
96STK390.58671192
97SGK10.58570073
98CAMK2D0.58075565
99STK110.57919978
100STK38L0.57784905
101WNK30.57776125
102PRKCE0.57280135
103PRKCH0.56834728
104ICK0.55444749
105FGR0.53766877
106PLK30.53173645
107CDC42BPA0.52669963
108MAP2K10.52003366
109MARK20.51443119
110CSNK1D0.50896498
111NME10.49493052
112BMPR20.49374284
113RET0.48071250
114ERBB20.47968198
115PIK3CA0.47944587
116PRKACA0.47053736
117CSNK1A10.46666445
118MAPK100.45647607
119CSNK1G20.45499749
120CAMK2G0.45378070
121MOS0.45342595
122DYRK1B0.45179842
123RPS6KA30.45136517
124PLK40.44810475
125SGK30.44625447
126ALK0.43424490
127PINK10.43159683
128WNK10.43100882
129MAPKAPK50.42934913
130TNK20.42916355
131TSSK60.42399481
132TXK0.41684333
133PDPK10.41334380
134PRKCI0.41291916
135VRK10.41141725
136PRKCZ0.39607578
137TGFBR10.39081275
138CAMK1G0.37679260
139BRSK10.36938463
140NEK20.36877386
141PDK10.35317231
142ERBB30.34647689
143LIMK10.34441499
144FLT30.33331248
145PRKCA0.32937192
146CSNK1E0.31623225

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.91665649
2Synaptic vesicle cycle_Homo sapiens_hsa047213.69695141
3GABAergic synapse_Homo sapiens_hsa047272.74022746
4Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.70772723
5Circadian entrainment_Homo sapiens_hsa047132.69722323
6Olfactory transduction_Homo sapiens_hsa047402.66853505
7Long-term potentiation_Homo sapiens_hsa047202.51201228
8Glutamatergic synapse_Homo sapiens_hsa047242.49142626
9Morphine addiction_Homo sapiens_hsa050322.48947095
10Amphetamine addiction_Homo sapiens_hsa050312.46411633
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.20371385
12Dopaminergic synapse_Homo sapiens_hsa047282.17649140
13Collecting duct acid secretion_Homo sapiens_hsa049662.05702906
14Insulin secretion_Homo sapiens_hsa049112.05035390
15Salivary secretion_Homo sapiens_hsa049702.04611526
16Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85941285
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.83106825
18Taste transduction_Homo sapiens_hsa047421.78462752
19Cholinergic synapse_Homo sapiens_hsa047251.76285276
20Long-term depression_Homo sapiens_hsa047301.75788219
21Serotonergic synapse_Homo sapiens_hsa047261.69530873
22Gastric acid secretion_Homo sapiens_hsa049711.67498278
23Cocaine addiction_Homo sapiens_hsa050301.65034640
24Aldosterone synthesis and secretion_Homo sapiens_hsa049251.63798738
25Renin secretion_Homo sapiens_hsa049241.61271561
26Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60685855
27Oxytocin signaling pathway_Homo sapiens_hsa049211.60672010
28Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.58989641
29Calcium signaling pathway_Homo sapiens_hsa040201.57907790
30Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.55404114
31Vibrio cholerae infection_Homo sapiens_hsa051101.48522267
32Protein export_Homo sapiens_hsa030601.47043141
33Butanoate metabolism_Homo sapiens_hsa006501.44562978
34Gap junction_Homo sapiens_hsa045401.40268925
35Basal cell carcinoma_Homo sapiens_hsa052171.36824139
36Nitrogen metabolism_Homo sapiens_hsa009101.36523088
37GnRH signaling pathway_Homo sapiens_hsa049121.35972200
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.30463263
39Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29644012
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26564591
41Axon guidance_Homo sapiens_hsa043601.26094037
42Linoleic acid metabolism_Homo sapiens_hsa005911.25016683
43Cardiac muscle contraction_Homo sapiens_hsa042601.18540866
44Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.16872389
45Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.15531169
46cAMP signaling pathway_Homo sapiens_hsa040241.15017755
47Basal transcription factors_Homo sapiens_hsa030221.14596322
48Ether lipid metabolism_Homo sapiens_hsa005651.14373002
49Melanogenesis_Homo sapiens_hsa049161.12555184
50RNA polymerase_Homo sapiens_hsa030201.12434971
51Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.10838264
52Estrogen signaling pathway_Homo sapiens_hsa049151.06276704
53Glioma_Homo sapiens_hsa052141.05821254
54Oocyte meiosis_Homo sapiens_hsa041141.02190636
55cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01175899
56Phosphatidylinositol signaling system_Homo sapiens_hsa040701.00544570
57ErbB signaling pathway_Homo sapiens_hsa040120.99708904
58Vascular smooth muscle contraction_Homo sapiens_hsa042700.97161338
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.96119738
60Fanconi anemia pathway_Homo sapiens_hsa034600.95919561
61Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.95127119
62Type II diabetes mellitus_Homo sapiens_hsa049300.92789807
63Regulation of autophagy_Homo sapiens_hsa041400.86804058
64Dilated cardiomyopathy_Homo sapiens_hsa054140.85619218
65Selenocompound metabolism_Homo sapiens_hsa004500.84749596
66Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.84215292
67Phototransduction_Homo sapiens_hsa047440.82500636
68Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81346134
69Maturity onset diabetes of the young_Homo sapiens_hsa049500.80078292
70Phospholipase D signaling pathway_Homo sapiens_hsa040720.77416643
71Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.76376089
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72978812
73MAPK signaling pathway_Homo sapiens_hsa040100.71613636
74Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.71308948
75Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.69256013
76Steroid biosynthesis_Homo sapiens_hsa001000.68705016
77Thyroid hormone synthesis_Homo sapiens_hsa049180.68469681
78Sulfur relay system_Homo sapiens_hsa041220.68100684
79Alcoholism_Homo sapiens_hsa050340.67738984
80RNA degradation_Homo sapiens_hsa030180.67358303
81Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.64992384
82Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.64943650
83Tryptophan metabolism_Homo sapiens_hsa003800.64145243
84Pancreatic secretion_Homo sapiens_hsa049720.64032150
85Dorso-ventral axis formation_Homo sapiens_hsa043200.63885320
86Wnt signaling pathway_Homo sapiens_hsa043100.61769987
87Ribosome_Homo sapiens_hsa030100.60681888
88Choline metabolism in cancer_Homo sapiens_hsa052310.59742492
89Homologous recombination_Homo sapiens_hsa034400.59629455
90Hedgehog signaling pathway_Homo sapiens_hsa043400.59281847
91Ras signaling pathway_Homo sapiens_hsa040140.59074691
92Propanoate metabolism_Homo sapiens_hsa006400.57961756
93* Glucagon signaling pathway_Homo sapiens_hsa049220.57859613
94Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57323590
95Rap1 signaling pathway_Homo sapiens_hsa040150.56779746
96Oxidative phosphorylation_Homo sapiens_hsa001900.55645688
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.55031423
98Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.54894864
99Alzheimers disease_Homo sapiens_hsa050100.53725894
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53080838
101Peroxisome_Homo sapiens_hsa041460.51435402
102Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.49756540
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.49660704
104Neurotrophin signaling pathway_Homo sapiens_hsa047220.48969957
105Circadian rhythm_Homo sapiens_hsa047100.48752914
106ABC transporters_Homo sapiens_hsa020100.48685213
107Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48431848
108Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.48356842
109Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.47157625
110Endocytosis_Homo sapiens_hsa041440.46850206
111Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.46410780
112Type I diabetes mellitus_Homo sapiens_hsa049400.46073710
113VEGF signaling pathway_Homo sapiens_hsa043700.44537405
114Inositol phosphate metabolism_Homo sapiens_hsa005620.43932745
115Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.43211887
116Melanoma_Homo sapiens_hsa052180.42268934
117Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42123204
118Caffeine metabolism_Homo sapiens_hsa002320.41960124
119Ovarian steroidogenesis_Homo sapiens_hsa049130.41552949
120Prion diseases_Homo sapiens_hsa050200.39622654
121Sphingolipid signaling pathway_Homo sapiens_hsa040710.38979612
122beta-Alanine metabolism_Homo sapiens_hsa004100.38222555
123Rheumatoid arthritis_Homo sapiens_hsa053230.38034806
124Renal cell carcinoma_Homo sapiens_hsa052110.37831196
125Glycerolipid metabolism_Homo sapiens_hsa005610.37676716
126Vitamin B6 metabolism_Homo sapiens_hsa007500.36381217
127Endometrial cancer_Homo sapiens_hsa052130.36170183
128Metabolic pathways_Homo sapiens_hsa011000.36111422
129Hippo signaling pathway_Homo sapiens_hsa043900.36043559
130mTOR signaling pathway_Homo sapiens_hsa041500.35701684
131Bile secretion_Homo sapiens_hsa049760.35339286
132Parkinsons disease_Homo sapiens_hsa050120.34149793
133Tight junction_Homo sapiens_hsa045300.33068220
134Huntingtons disease_Homo sapiens_hsa050160.31741913
135Colorectal cancer_Homo sapiens_hsa052100.31569716
136Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.31268400
137Central carbon metabolism in cancer_Homo sapiens_hsa052300.29068832
138Non-small cell lung cancer_Homo sapiens_hsa052230.29066264
139Insulin signaling pathway_Homo sapiens_hsa049100.28907204
140Phagosome_Homo sapiens_hsa041450.27923682

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