CPXCR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is one of several genes identified in a region of the X chromosome associated with an X-linked cleft palate (CPX) disorder. The encoded protein contains a motif similar to a motif found in zinc-finger proteins. Mutation analysis of this gene has not revealed any mutation which causes the CPX disorder. Multiple alternatively spliced variants, encoding the same protein, have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1reproduction (GO:0000003)9.94978547
2epithelial cilium movement (GO:0003351)9.86830319
3axonemal dynein complex assembly (GO:0070286)9.61887695
4spermatid development (GO:0007286)9.42296771
5cilium or flagellum-dependent cell motility (GO:0001539)9.28823948
6motile cilium assembly (GO:0044458)9.20045265
7cilium movement (GO:0003341)7.96110811
8single fertilization (GO:0007338)7.77128476
9regulation of cilium movement (GO:0003352)7.64033327
10epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)7.59959100
11male meiosis (GO:0007140)7.17369652
12piRNA metabolic process (GO:0034587)7.00911580
13sperm capacitation (GO:0048240)6.86155064
14synaptonemal complex organization (GO:0070193)6.75564556
15synaptonemal complex assembly (GO:0007130)6.74284943
16microtubule depolymerization (GO:0007019)6.72584922
17spermatogenesis (GO:0007283)6.52431304
18fertilization (GO:0009566)6.51751906
19male gamete generation (GO:0048232)6.50000991
20negative regulation of inclusion body assembly (GO:0090084)6.08743252
21gamete generation (GO:0007276)5.99888302
22organic cation transport (GO:0015695)5.80915749
23calcium ion-dependent exocytosis (GO:0017156)5.44496435
24cellular process involved in reproduction in multicellular organism (GO:0022412)5.35311488
25germ cell development (GO:0007281)5.31297411
26regulation of inclusion body assembly (GO:0090083)5.28411755
27glycerol ether metabolic process (GO:0006662)5.17819883
28spermatid nucleus differentiation (GO:0007289)5.08921570
29cell recognition (GO:0008037)5.08794397
30ventricular system development (GO:0021591)5.07809544
31DNA methylation involved in gamete generation (GO:0043046)4.80001575
32chromosome organization involved in meiosis (GO:0070192)4.79229208
33ether metabolic process (GO:0018904)4.78005730
34multicellular organismal reproductive process (GO:0048609)4.72786712
35male meiosis I (GO:0007141)4.56616008
36regulation of microtubule-based movement (GO:0060632)4.46619184
37seminiferous tubule development (GO:0072520)4.43994040
38chromosome condensation (GO:0030261)4.39028211
39microtubule severing (GO:0051013)4.15630855
40meiotic nuclear division (GO:0007126)4.13928076
41DNA packaging (GO:0006323)4.09573666
42left/right pattern formation (GO:0060972)4.01217490
43genitalia morphogenesis (GO:0035112)4.01154631
44sequestering of actin monomers (GO:0042989)3.93380079
45single strand break repair (GO:0000012)3.89093887
46sexual reproduction (GO:0019953)3.88024904
47monoubiquitinated protein deubiquitination (GO:0035520)3.87586976
48multicellular organismal development (GO:0007275)3.84172759
49chaperone-mediated protein complex assembly (GO:0051131)3.79096978
50protein K11-linked deubiquitination (GO:0035871)3.78469812
51meiosis I (GO:0007127)3.63839052
52microtubule polymerization or depolymerization (GO:0031109)3.47990221
53GTP biosynthetic process (GO:0006183)3.44475329
54nucleoside diphosphate phosphorylation (GO:0006165)3.29923145
55meiotic cell cycle (GO:0051321)3.18333542
56polyol catabolic process (GO:0046174)3.17808383
57regulation of spindle checkpoint (GO:0090231)3.14395844
58synapsis (GO:0007129)3.13812591
59mitotic sister chromatid cohesion (GO:0007064)3.11747004
60protein polyglutamylation (GO:0018095)3.08660089
61lactate metabolic process (GO:0006089)3.08103501
62alditol metabolic process (GO:0019400)3.07101791
63glycolytic process (GO:0006096)3.06736936
64UTP biosynthetic process (GO:0006228)3.05107432
65protein localization to cilium (GO:0061512)2.94247807
66amino-acid betaine transport (GO:0015838)2.90316200
67carnitine transport (GO:0015879)2.90316200
68nucleus organization (GO:0006997)2.88769175
69carnitine transmembrane transport (GO:1902603)2.77160127
70cellular component assembly involved in morphogenesis (GO:0010927)2.76515298
71cilium organization (GO:0044782)2.76043877
72UTP metabolic process (GO:0046051)2.74431043
73meiotic cell cycle process (GO:1903046)2.72787479
74interferon-gamma secretion (GO:0072643)2.72045240
75regulation of centriole replication (GO:0046599)2.69852848
76microtubule-based movement (GO:0007018)2.67379479
77protein refolding (GO:0042026)2.66680497
78cilium assembly (GO:0042384)2.66542271
79cilium morphogenesis (GO:0060271)2.64165598
80glycerol metabolic process (GO:0006071)2.63883916
81centriole assembly (GO:0098534)2.61523259
82axoneme assembly (GO:0035082)2.57511650
83RNA localization (GO:0006403)2.47682392
84single-organism membrane fusion (GO:0044801)2.44752947
85intraciliary transport (GO:0042073)2.41912768
86cell redox homeostasis (GO:0045454)2.39774283
87polyamine biosynthetic process (GO:0006596)2.38061694
88negative regulation of organelle assembly (GO:1902116)2.33403974
89positive regulation of macrophage activation (GO:0043032)2.30531862
90fusion of sperm to egg plasma membrane (GO:0007342)14.7908591
91sperm motility (GO:0030317)13.8726174
92acrosome assembly (GO:0001675)12.9120674
93cell wall macromolecule catabolic process (GO:0016998)12.8630769
94cell wall macromolecule metabolic process (GO:0044036)12.8630769
95multicellular organism reproduction (GO:0032504)11.6839387
96acrosome reaction (GO:0007340)11.6112369
97sperm-egg recognition (GO:0035036)11.6095569
98plasma membrane fusion (GO:0045026)11.2985588
99binding of sperm to zona pellucida (GO:0007339)10.5881693
100cell-cell recognition (GO:0009988)10.4268353

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.40304920
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.50547097
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.31746343
4EZH2_22144423_ChIP-Seq_EOC_Human4.01254442
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.19259515
6PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse3.00360849
7FLI1_27457419_Chip-Seq_LIVER_Mouse2.82416992
8ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.47997742
9PCGF2_27294783_Chip-Seq_ESCs_Mouse2.44454089
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.35327966
11ZNF274_21170338_ChIP-Seq_K562_Hela2.21904443
12KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse2.00323634
13VDR_22108803_ChIP-Seq_LS180_Human1.99559992
14EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.95426622
15CBX2_27304074_Chip-Seq_ESCs_Mouse1.95125578
16* KAP1_22055183_ChIP-Seq_ESCs_Mouse1.91606724
17PCGF2_27294783_Chip-Seq_NPCs_Mouse1.85726215
18STAT6_21828071_ChIP-Seq_BEAS2B_Human1.78858530
19STAT1_17558387_ChIP-Seq_HELA_Human1.76940580
20KDM2B_26808549_Chip-Seq_REH_Human1.76845212
21RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.73957405
22MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.68389539
23NFE2_27457419_Chip-Seq_LIVER_Mouse1.68362407
24ZFP57_27257070_Chip-Seq_ESCs_Mouse1.67958422
25SUZ12_27294783_Chip-Seq_NPCs_Mouse1.65716659
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.64968930
27TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.60975353
28CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.60024875
29TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.57812024
30ELK4_26923725_Chip-Seq_MESODERM_Mouse1.56837488
31TAL1_26923725_Chip-Seq_HPCs_Mouse1.54434434
32NANOG_18555785_Chip-Seq_ESCs_Mouse1.48050306
33SOX2_22085726_ChIP-Seq_NPCs_Mouse1.45989735
34MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41427163
35GATA1_26923725_Chip-Seq_HPCs_Mouse1.38786882
36GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.38350469
37EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.38299562
38WDR5_24793694_ChIP-Seq_LNCAP_Human1.36981408
39P53_22387025_ChIP-Seq_ESCs_Mouse1.36909397
40FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.34510224
41CMYC_18555785_Chip-Seq_ESCs_Mouse1.30349887
42CRX_20693478_ChIP-Seq_RETINA_Mouse1.29963124
43GATA3_21867929_ChIP-Seq_CD8_Mouse1.29280555
44OCT4_18555785_Chip-Seq_ESCs_Mouse1.28972373
45POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.28949523
46TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28949523
47TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27924021
48REST_21632747_ChIP-Seq_MESCs_Mouse1.27728833
49IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.26988439
50CBP_20019798_ChIP-Seq_JUKART_Human1.26988439
51EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.26173557
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.25599579
53GATA3_21867929_ChIP-Seq_TH1_Mouse1.25260345
54P300_18555785_Chip-Seq_ESCs_Mouse1.24304692
55GF1_26923725_Chip-Seq_HPCs_Mouse1.24267770
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.23292706
57CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.21616089
58NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.20671744
59SUZ12_18555785_Chip-Seq_ESCs_Mouse1.20634592
60PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.19586269
61EZH2_27294783_Chip-Seq_NPCs_Mouse1.19421663
62* RNF2_27304074_Chip-Seq_NSC_Mouse1.18684991
63ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.16032184
64FLI1_21867929_ChIP-Seq_TH2_Mouse1.15493304
65EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.14243218
66KLF4_18555785_Chip-Seq_ESCs_Mouse1.13510525
67STAT3_18555785_Chip-Seq_ESCs_Mouse1.11914505
68ESRRB_18555785_Chip-Seq_ESCs_Mouse1.10928391
69ESET_19884257_ChIP-Seq_ESCs_Mouse1.10825437
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.10180388
71CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.10152261
72SOX2_18555785_Chip-Seq_ESCs_Mouse1.10119045
73SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.09545018
74LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.08606170
75P53_21459846_ChIP-Seq_SAOS-2_Human1.08115781
76OCT4_21477851_ChIP-Seq_ESCs_Mouse1.08089120
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.07847138
78PU1_27457419_Chip-Seq_LIVER_Mouse1.06392721
79NMYC_18555785_Chip-Seq_ESCs_Mouse1.03144191
80PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03124097
81SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.02538176
82CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.99529047
83FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99396131
84RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98024258
85RUNX1_27457419_Chip-Seq_LIVER_Mouse0.97427774
86SOX9_26525672_Chip-Seq_HEART_Mouse0.96165825
87NFYB_21822215_ChIP-Seq_K562_Human0.95413196
88CTCF_18555785_Chip-Seq_ESCs_Mouse0.94787464
89ERG_20517297_ChIP-Seq_VCAP_Human0.93827514
90SMAD1_18555785_Chip-Seq_ESCs_Mouse0.93412670
91RAD21_21589869_ChIP-Seq_MESCs_Mouse0.92997657
92SPI1_26923725_Chip-Seq_HPCs_Mouse0.92473684
93ZFX_18555785_Chip-Seq_ESCs_Mouse0.92421407
94SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91854044
95TBL1_22424771_ChIP-Seq_293T_Human0.91628847
96GF1B_26923725_Chip-Seq_HPCs_Mouse0.90491100
97PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.90119493
98PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.89175058
99STAT3_18555785_ChIP-Seq_MESCs_Mouse0.87530426
100SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86378740

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.97520689
2MP0001929_abnormal_gametogenesis5.50931735
3MP0008877_abnormal_DNA_methylation4.20218855
4MP0002210_abnormal_sex_determination3.41132126
5MP0002161_abnormal_fertility/fecundity3.22410852
6MP0001145_abnormal_male_reproductive2.84501547
7MP0000653_abnormal_sex_gland2.53924360
8MP0005670_abnormal_white_adipose2.47284850
9MP0009278_abnormal_bone_marrow2.04620686
10MP0002102_abnormal_ear_morphology2.02099716
11MP0005410_abnormal_fertilization16.0784329
12MP0002653_abnormal_ependyma_morphology1.68259453
13MP0002160_abnormal_reproductive_system1.56720200
14MP0008995_early_reproductive_senescence1.50113952
15MP0002234_abnormal_pharynx_morphology1.42771082
16MP0003950_abnormal_plasma_membrane1.36449721
17MP0005623_abnormal_meninges_morphology1.28483051
18MP0001765_abnormal_ion_homeostasis1.27248580
19MP0005397_hematopoietic_system_phenotyp1.24125598
20MP0001545_abnormal_hematopoietic_system1.24125598
21MP0008058_abnormal_DNA_repair1.17182300
22MP0005647_abnormal_sex_gland1.13096205
23MP0002282_abnormal_trachea_morphology1.06915549
24MP0005389_reproductive_system_phenotype0.97039819
25MP0004036_abnormal_muscle_relaxation0.95640947
26MP0008057_abnormal_DNA_replication0.89592365
27MP0003646_muscle_fatigue0.81878869
28MP0008007_abnormal_cellular_replicative0.81857094
29MP0009046_muscle_twitch0.79688003
30MP0000566_synostosis0.78143534
31MP0004233_abnormal_muscle_weight0.68022936
32MP0005636_abnormal_mineral_homeostasis0.63647725
33MP0001727_abnormal_embryo_implantation0.63600396
34MP0003786_premature_aging0.59234426
35MP0010094_abnormal_chromosome_stability0.58681104
36MP0001984_abnormal_olfaction0.58347926
37MP0003136_yellow_coat_color0.56376980
38MP0001293_anophthalmia0.55417787
39MP0002736_abnormal_nociception_after0.54956003
40MP0001986_abnormal_taste_sensitivity0.52003728
41MP0002928_abnormal_bile_duct0.50536085
42MP0003699_abnormal_female_reproductive0.50078456
43MP0001968_abnormal_touch/_nociception0.49715717
44MP0008961_abnormal_basal_metabolism0.48744440
45MP0001324_abnormal_eye_pigmentation0.46165654
46MP0001119_abnormal_female_reproductive0.44076826
47MP0004808_abnormal_hematopoietic_stem0.41794726
48MP0000015_abnormal_ear_pigmentation0.41489484
49MP0005551_abnormal_eye_electrophysiolog0.40975444
50MP0001919_abnormal_reproductive_system0.39885533
51MP0005365_abnormal_bile_salt0.39647829
52MP0003111_abnormal_nucleus_morphology0.39520974
53MP0005409_darkened_coat_color0.39044308
54MP0002735_abnormal_chemical_nociception0.39036255
55MP0001764_abnormal_homeostasis0.38596887
56MP0004484_altered_response_of0.38237324
57MP0003011_delayed_dark_adaptation0.36138520
58MP0005503_abnormal_tendon_morphology0.34897334
59MP0004147_increased_porphyrin_level0.34849814
60MP0005253_abnormal_eye_physiology0.32757220
61MP0000678_abnormal_parathyroid_gland0.31842026
62MP0003115_abnormal_respiratory_system0.31590100
63MP0001873_stomach_inflammation0.31503603
64MP0005391_vision/eye_phenotype0.31004148
65MP0001270_distended_abdomen0.28460513
66MP0000462_abnormal_digestive_system0.27573495
67MP0003878_abnormal_ear_physiology0.27560882
68MP0005377_hearing/vestibular/ear_phenot0.27560882
69MP0000372_irregular_coat_pigmentation0.27215473
70MP0002168_other_aberrant_phenotype0.26871416
71MP0004019_abnormal_vitamin_homeostasis0.26477207
72MP0003091_abnormal_cell_migration0.26067340
73MP0003879_abnormal_hair_cell0.24427084
74MP0002139_abnormal_hepatobiliary_system0.24415183
75MP0005666_abnormal_adipose_tissue0.24237709
76MP0003633_abnormal_nervous_system0.23909404
77MP0003631_nervous_system_phenotype0.23421227
78MP0001963_abnormal_hearing_physiology0.22225724
79MP0002108_abnormal_muscle_morphology0.22044371
80MP0002092_abnormal_eye_morphology0.21881519
81MP0003861_abnormal_nervous_system0.21768544
82MP0003045_fibrosis0.20676481
83MP0004133_heterotaxia0.20565338
84MP0002295_abnormal_pulmonary_circulatio0.20284965
85MP0002152_abnormal_brain_morphology0.19673512
86MP0000569_abnormal_digit_pigmentation0.18535702
87MP0002873_normal_phenotype0.17796253
88MP0002169_no_abnormal_phenotype0.17313978
89MP0002796_impaired_skin_barrier0.16960179
90MP0002971_abnormal_brown_adipose0.16797866
91MP0009115_abnormal_fat_cell0.16282164
92MP0009379_abnormal_foot_pigmentation0.15908617
93MP0000534_abnormal_ureter_morphology0.15042458
94MP0003943_abnormal_hepatobiliary_system0.14017041
95MP0002269_muscular_atrophy0.13491091
96MP0003077_abnormal_cell_cycle0.13418134
97MP0005085_abnormal_gallbladder_physiolo0.13009110
98MP0001486_abnormal_startle_reflex0.12973289
99MP0001299_abnormal_eye_distance/0.12823131
100MP0000313_abnormal_cell_death0.12650720

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)9.70644768
2Abnormal respiratory epithelium morphology (HP:0012253)9.56850046
3Abnormal respiratory motile cilium morphology (HP:0005938)9.56850046
4Abnormal ciliary motility (HP:0012262)8.11906644
5Chronic bronchitis (HP:0004469)7.52104598
6Rhinitis (HP:0012384)7.38449198
7Infertility (HP:0000789)6.56519337
8Nasal polyposis (HP:0100582)5.88600573
9Abnormality of the nasal mucosa (HP:0000433)4.82330620
10Male infertility (HP:0003251)4.55937666
11Bronchitis (HP:0012387)4.20666625
12Bronchiectasis (HP:0002110)4.13565260
13Recurrent sinusitis (HP:0011108)3.87931486
14Nephronophthisis (HP:0000090)3.87775301
15Abnormal spermatogenesis (HP:0008669)3.28401529
16Recurrent otitis media (HP:0000403)3.07222857
17Abnormality of the renal medulla (HP:0100957)3.06603738
18Tubulointerstitial nephritis (HP:0001970)2.68555278
19Abnormality of midbrain morphology (HP:0002418)2.32098881
20Molar tooth sign on MRI (HP:0002419)2.32098881
21Dyschromatopsia (HP:0007641)2.25331221
22Tubular atrophy (HP:0000092)2.14357607
23Medial flaring of the eyebrow (HP:0010747)2.13894164
24Tubulointerstitial abnormality (HP:0001969)2.10348666
25Azoospermia (HP:0000027)2.09088125
26Absent/shortened dynein arms (HP:0200106)14.0706033
27Dynein arm defect of respiratory motile cilia (HP:0012255)14.0706033
28Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.1118813
29Recurrent bronchitis (HP:0002837)1.99707976
30Congenital malformation of the right heart (HP:0011723)1.98618423
31Double outlet right ventricle (HP:0001719)1.98618423
32Gonadotropin excess (HP:0000837)1.94964539
33Decreased central vision (HP:0007663)1.91781981
34Abnormality of the renal cortex (HP:0011035)1.82637268
35Impulsivity (HP:0100710)1.78583904
36Hypoplasia of the capital femoral epiphysis (HP:0003090)1.77525987
37Asymmetric septal hypertrophy (HP:0001670)1.76100754
38Congenital hepatic fibrosis (HP:0002612)1.72761556
39Stage 5 chronic kidney disease (HP:0003774)1.70711583
40Postaxial foot polydactyly (HP:0001830)1.68590868
41Spastic tetraparesis (HP:0001285)1.64780285
42Renal dysplasia (HP:0000110)1.64103765
43Abnormality of renal excretion (HP:0011036)1.62501583
44Abnormality of permanent molar morphology (HP:0011071)1.61730232
45Abnormality of the dental root (HP:0006486)1.61730232
46Taurodontia (HP:0000679)1.61730232
47Abnormal gallbladder physiology (HP:0012438)1.60714422
48Cholecystitis (HP:0001082)1.60714422
49Tubulointerstitial fibrosis (HP:0005576)1.54358697
50Hemorrhage of the eye (HP:0011885)1.54277576
51Abnormality of molar (HP:0011077)1.52452162
52Abnormality of molar morphology (HP:0011070)1.52452162
53Abnormality of the dental pulp (HP:0006479)1.47728129
54Fibular hypoplasia (HP:0003038)1.47397533
55Vascular calcification (HP:0004934)1.45659753
56Abnormal biliary tract physiology (HP:0012439)1.45405165
57Bile duct proliferation (HP:0001408)1.45405165
58Abnormal drinking behavior (HP:0030082)1.42128029
59Polydipsia (HP:0001959)1.42128029
60Choroideremia (HP:0001139)1.39529211
61Bell-shaped thorax (HP:0001591)1.38142234
62Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.37374404
63Absent epiphyses (HP:0010577)1.37374404
64Constricted visual fields (HP:0001133)1.33161468
65Exercise-induced myalgia (HP:0003738)1.31105238
66Postaxial hand polydactyly (HP:0001162)1.29609914
67Cardiovascular calcification (HP:0011915)1.28940185
68Microglossia (HP:0000171)1.27963575
69True hermaphroditism (HP:0010459)1.27391517
70Abdominal situs inversus (HP:0003363)1.27051554
71Abnormality of abdominal situs (HP:0011620)1.27051554
72Abnormal ventriculo-arterial connection (HP:0011563)1.24457412
73Transposition of the great arteries (HP:0001669)1.24457412
74Abnormal connection of the cardiac segments (HP:0011545)1.24457412
75Oculomotor apraxia (HP:0000657)1.24257361
76Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.22597468
77Renovascular hypertension (HP:0100817)1.21904102
78Aplasia/Hypoplasia of the lens (HP:0008063)1.21856008
79Abnormal urine output (HP:0012590)1.21522845
80Decreased electroretinogram (ERG) amplitude (HP:0000654)1.21096555
81Tetany (HP:0001281)1.20771542
82Elfin facies (HP:0004428)1.20686861
83J-shaped sella turcica (HP:0002680)1.19575985
84Heterotopia (HP:0002282)1.18657518
85Short ribs (HP:0000773)1.18131987
86Chronic sinusitis (HP:0011109)1.16928467
87Short femoral neck (HP:0100864)1.16478433
88Bundle branch block (HP:0011710)1.16227993
89Facial cleft (HP:0002006)1.16021232
90Cystic liver disease (HP:0006706)1.15536695
91Pachygyria (HP:0001302)1.14022303
92Flattened epiphyses (HP:0003071)1.13788255
93Gait imbalance (HP:0002141)1.13444329
94Abnormality of dentin (HP:0010299)1.12345802
95Abnormality of the lower motor neuron (HP:0002366)1.12114132
96Hyperphosphatemia (HP:0002905)1.12113158
97Absent frontal sinuses (HP:0002688)1.11909527
98Sensory axonal neuropathy (HP:0003390)1.11851372
99Congenital primary aphakia (HP:0007707)1.11365979
100Aplasia/Hypoplasia of the tongue (HP:0010295)1.11297327

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK49.03414030
2PDK39.03414030
3PDK25.98957373
4TESK14.65886026
5PRKD34.02762929
6ICK3.45989464
7STK392.02551330
8PTK2B1.97883261
9WNK41.96962304
10PNCK1.70194096
11STK381.39475595
12DYRK1B1.26148516
13PDK11.26018435
14NEK21.25876915
15DYRK30.91922772
16TYRO30.85510867
17IRAK10.80831608
18INSRR0.80751793
19NTRK20.78143567
20MAPK150.75968677
21WNK10.72835483
22OBSCN0.70924972
23PDPK10.69204721
24TTK0.64612065
25CAMK1G0.59854134
26CHEK20.58718209
27PINK10.57740515
28PASK0.57654728
29NTRK10.56737261
30MAP2K60.56554062
31STK30.53424812
32GRK10.51973410
33NLK0.48939767
34IRAK20.47797163
35RIPK40.43780988
36CHEK10.43250435
37MUSK0.43152720
38CCNB10.43058651
39LMTK20.41480444
40PKN10.41459741
41MARK20.40238287
42EEF2K0.39855766
43STK38L0.39019597
44PIM10.36209024
45WNK30.36078920
46PRKCG0.35237330
47ATM0.33866300
48MST40.31134122
49TESK20.30918992
50WEE10.29394308
51PAK10.26578132
52FRK0.25348829
53CAMKK10.24040434
54PLK10.24018188
55NEK60.20464318
56FGFR20.20181933
57ATR0.17709236
58RPS6KB10.17662855
59MAPKAPK50.17449182
60PLK40.17417424
61PAK60.16225009
62PRKG20.15841769
63BRSK20.15708232
64PRKCQ0.14347945
65MELK0.14336995
66CSNK1E0.14108406
67PRKG10.13969755
68MAP3K50.13369039
69PAK20.12245593
70PRKAA10.11820532
71MTOR0.10837626
72CSNK2A10.09539131
73PRKCZ0.09528221
74CAMK2A0.08728844
75CSNK1D0.08208362
76PRPF4B0.08124136
77CDK150.07710012
78ADRBK20.07667706
79GSK3B0.07545079
80CSNK2A20.07136510
81CDK10.05976605
82PAK40.05792772
83PRKACG0.05600805
84YES10.05441019
85TBK10.05224832
86STK110.04841135
87MAP3K100.04751991
88CDK60.04620671
89CDK180.04540459
90EGFR0.04457054
91CDK20.03657139
92PRKACA0.03622084
93PRKACB0.03459026
94BRSK10.03207785
95GSK3A0.02989958
96CDK11A0.02938703
97MAPK10.02269347
98RPS6KA30.02115086
99PIM20.02014448
100MAPK80.01777014

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007506.16153741
2Glycolysis / Gluconeogenesis_Homo sapiens_hsa000104.15439383
3Fatty acid biosynthesis_Homo sapiens_hsa000614.09581365
4Pyruvate metabolism_Homo sapiens_hsa006203.60601313
5Propanoate metabolism_Homo sapiens_hsa006403.28424162
6Glucagon signaling pathway_Homo sapiens_hsa049222.80596698
7alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.51871593
8Linoleic acid metabolism_Homo sapiens_hsa005912.45108142
9Basal transcription factors_Homo sapiens_hsa030222.35844677
10PPAR signaling pathway_Homo sapiens_hsa033202.28529972
11Glycosaminoglycan degradation_Homo sapiens_hsa005312.26606041
12Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049642.17058070
13Carbohydrate digestion and absorption_Homo sapiens_hsa049731.91742469
14Selenocompound metabolism_Homo sapiens_hsa004501.82922070
15Glycerolipid metabolism_Homo sapiens_hsa005611.82233503
16Pentose phosphate pathway_Homo sapiens_hsa000301.75710661
17Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.73766579
18Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.66014533
19Oocyte meiosis_Homo sapiens_hsa041141.65810225
20Amphetamine addiction_Homo sapiens_hsa050311.65047397
21Fanconi anemia pathway_Homo sapiens_hsa034601.64959930
22Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.49047790
23Fructose and mannose metabolism_Homo sapiens_hsa000511.45172982
24Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.43897244
25Mineral absorption_Homo sapiens_hsa049781.36835913
26Renin secretion_Homo sapiens_hsa049241.34592486
27Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.33104530
28Glycerophospholipid metabolism_Homo sapiens_hsa005641.26378121
29Ether lipid metabolism_Homo sapiens_hsa005651.19055698
30Fatty acid metabolism_Homo sapiens_hsa012121.18287661
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.17630837
32Dorso-ventral axis formation_Homo sapiens_hsa043201.13746723
33Fatty acid degradation_Homo sapiens_hsa000711.12789832
34Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05423288
35Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.03627949
36Carbon metabolism_Homo sapiens_hsa012001.03531026
37Cardiac muscle contraction_Homo sapiens_hsa042600.98742948
38Collecting duct acid secretion_Homo sapiens_hsa049660.96747299
39Fat digestion and absorption_Homo sapiens_hsa049750.95423157
40Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92450434
41Purine metabolism_Homo sapiens_hsa002300.89906632
42cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88777254
43Insulin secretion_Homo sapiens_hsa049110.87991210
44Long-term potentiation_Homo sapiens_hsa047200.86409163
45Taste transduction_Homo sapiens_hsa047420.86015945
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.85362250
47Antigen processing and presentation_Homo sapiens_hsa046120.84358030
48Estrogen signaling pathway_Homo sapiens_hsa049150.81467912
49Chemical carcinogenesis_Homo sapiens_hsa052040.77881832
50Sphingolipid metabolism_Homo sapiens_hsa006000.76058539
51Thyroid hormone synthesis_Homo sapiens_hsa049180.74128374
52Biosynthesis of amino acids_Homo sapiens_hsa012300.74047708
53ABC transporters_Homo sapiens_hsa020100.67989579
54Glutathione metabolism_Homo sapiens_hsa004800.66075250
55Huntingtons disease_Homo sapiens_hsa050160.64208175
56Bile secretion_Homo sapiens_hsa049760.61995845
57Calcium signaling pathway_Homo sapiens_hsa040200.60239334
58Salivary secretion_Homo sapiens_hsa049700.59481880
59mRNA surveillance pathway_Homo sapiens_hsa030150.57511626
60Adipocytokine signaling pathway_Homo sapiens_hsa049200.57361935
61Arachidonic acid metabolism_Homo sapiens_hsa005900.52336926
62Protein digestion and absorption_Homo sapiens_hsa049740.50752757
63RNA transport_Homo sapiens_hsa030130.48140370
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.47839189
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.45903984
66Central carbon metabolism in cancer_Homo sapiens_hsa052300.43902071
67Pancreatic secretion_Homo sapiens_hsa049720.42826879
68Inositol phosphate metabolism_Homo sapiens_hsa005620.42116805
69cAMP signaling pathway_Homo sapiens_hsa040240.39005583
70Glutamatergic synapse_Homo sapiens_hsa047240.38452546
71Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.38373978
72Gastric acid secretion_Homo sapiens_hsa049710.36713047
73B cell receptor signaling pathway_Homo sapiens_hsa046620.34438383
74VEGF signaling pathway_Homo sapiens_hsa043700.33924070
75Metabolic pathways_Homo sapiens_hsa011000.32630303
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.32404245
77Vitamin digestion and absorption_Homo sapiens_hsa049770.32295709
78Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.30652567
79Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.30601200
80Hedgehog signaling pathway_Homo sapiens_hsa043400.29516357
81Circadian entrainment_Homo sapiens_hsa047130.28739118
82Rheumatoid arthritis_Homo sapiens_hsa053230.27982242
83AMPK signaling pathway_Homo sapiens_hsa041520.27652929
84Thyroid hormone signaling pathway_Homo sapiens_hsa049190.27464698
85Steroid hormone biosynthesis_Homo sapiens_hsa001400.27333469
86Cocaine addiction_Homo sapiens_hsa050300.26547193
87Endocytosis_Homo sapiens_hsa041440.23661150
88Legionellosis_Homo sapiens_hsa051340.22908864
89Synaptic vesicle cycle_Homo sapiens_hsa047210.22258527
90Sulfur metabolism_Homo sapiens_hsa009200.20325842
91Wnt signaling pathway_Homo sapiens_hsa043100.19647329
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.19579527
93Renin-angiotensin system_Homo sapiens_hsa046140.18561481
94Aldosterone synthesis and secretion_Homo sapiens_hsa049250.17538514
95Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.16286511
96Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15562423
97Axon guidance_Homo sapiens_hsa043600.14916096
98Retinol metabolism_Homo sapiens_hsa008300.14756475
99T cell receptor signaling pathway_Homo sapiens_hsa046600.11276206
100Olfactory transduction_Homo sapiens_hsa047400.10726542

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