CPXM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene likely encodes a member of the carboxypeptidase family of proteins. Cloning of a comparable locus in mouse indicates that the encoded protein contains a discoidin domain and a carboxypeptidase domain, but the protein appears to lack residues necessary for carboxypeptidase activity. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)7.27242578
2bone trabecula formation (GO:0060346)6.57498741
3collagen fibril organization (GO:0030199)5.46337131
4extracellular fibril organization (GO:0043206)4.91344135
5planar cell polarity pathway involved in neural tube closure (GO:0090179)4.76028246
6ribosomal small subunit assembly (GO:0000028)4.63630364
7viral transcription (GO:0019083)4.55639699
8protein-DNA complex disassembly (GO:0032986)4.39404655
9nucleosome disassembly (GO:0006337)4.39404655
10regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.38598297
11collagen metabolic process (GO:0032963)4.37228603
12collagen catabolic process (GO:0030574)4.30375270
13fibril organization (GO:0097435)4.29093780
14translational termination (GO:0006415)4.23950833
15chondrocyte proliferation (GO:0035988)4.22719270
16outer ear morphogenesis (GO:0042473)4.20850280
17negative regulation of mRNA splicing, via spliceosome (GO:0048025)4.17437864
18sequestering of extracellular ligand from receptor (GO:0035581)4.15795882
19paraxial mesoderm development (GO:0048339)4.12843472
20multicellular organismal macromolecule metabolic process (GO:0044259)4.10570749
21multicellular organismal catabolic process (GO:0044243)3.93873570
22negative regulation of chondrocyte differentiation (GO:0032331)3.87144555
23multicellular organismal metabolic process (GO:0044236)3.84924201
24dermatan sulfate biosynthetic process (GO:0030208)3.81283862
25glomerular basement membrane development (GO:0032836)3.80821296
26neuron projection extension involved in neuron projection guidance (GO:1902284)3.79574354
27axon extension involved in axon guidance (GO:0048846)3.79574354
28dosage compensation (GO:0007549)3.77396346
29keratan sulfate catabolic process (GO:0042340)3.76789779
30negative regulation of erythrocyte differentiation (GO:0045647)3.75269361
31definitive hemopoiesis (GO:0060216)3.73691621
32enteric nervous system development (GO:0048484)3.68206621
33translational elongation (GO:0006414)3.67105310
34endodermal cell differentiation (GO:0035987)3.64559922
35extracellular matrix disassembly (GO:0022617)3.62577390
36polarized epithelial cell differentiation (GO:0030859)3.61530972
37nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.60625057
38skin morphogenesis (GO:0043589)3.60254208
39craniofacial suture morphogenesis (GO:0097094)3.58549201
40embryonic digestive tract development (GO:0048566)3.58386317
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.58323021
42dermatan sulfate metabolic process (GO:0030205)3.57126874
43glomerular filtration (GO:0003094)3.56699586
44blood vessel maturation (GO:0001955)3.54972152
45positive regulation of hematopoietic progenitor cell differentiation (GO:1901534)3.54360556
46positive regulation of megakaryocyte differentiation (GO:0045654)3.52303498
47cell proliferation involved in metanephros development (GO:0072203)3.51119137
48G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.49265346
49mRNA splice site selection (GO:0006376)3.48687056
50positive regulation of receptor biosynthetic process (GO:0010870)3.47247256
51DNA ligation (GO:0006266)3.46987122
52metanephric mesenchyme development (GO:0072075)3.46820693
53regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.45797645
54somatic stem cell division (GO:0048103)3.44609523
55DNA integration (GO:0015074)3.44562096
56deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.43837375
57negative regulation of RNA splicing (GO:0033119)3.43056961
58negative regulation of cartilage development (GO:0061037)3.41727506
59regulation of SMAD protein import into nucleus (GO:0060390)3.41554509
60endothelium development (GO:0003158)3.41282643
61negative regulation of mRNA processing (GO:0050686)3.40913590
62mesenchymal-epithelial cell signaling (GO:0060638)3.39767040
63SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.37985963
64protein complex disassembly (GO:0043241)3.37522846
65cell migration involved in heart development (GO:0060973)3.36801172
66extracellular matrix assembly (GO:0085029)3.35690330
67pyrimidine nucleotide catabolic process (GO:0006244)3.34577627
68mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.31616768
69regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.30207042
70Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.30022830
71cell differentiation involved in metanephros development (GO:0072202)3.29068698
72cotranslational protein targeting to membrane (GO:0006613)3.27994635
73peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.26982170
74negative regulation of embryonic development (GO:0045992)3.26929044
75kidney mesenchyme development (GO:0072074)3.25399799
76renal filtration (GO:0097205)3.25033323
77cell proliferation involved in kidney development (GO:0072111)3.24256123
78basement membrane organization (GO:0071711)3.23253513
79regulation of penile erection (GO:0060405)3.22403315
80protein targeting to ER (GO:0045047)3.21563451
81viral life cycle (GO:0019058)3.21537760
82regulation of histone H3-K9 methylation (GO:0051570)3.20263666
83positive regulation of SMAD protein import into nucleus (GO:0060391)3.20232045
84pyrimidine nucleobase catabolic process (GO:0006208)3.18601620
85cellular response to vitamin (GO:0071295)3.18055403
86spinal cord association neuron differentiation (GO:0021527)3.17888828
87gonadal mesoderm development (GO:0007506)3.17715750
88non-canonical Wnt signaling pathway (GO:0035567)3.17493291
89tongue development (GO:0043586)3.17290593
90hyperosmotic salinity response (GO:0042538)3.16674829
91cellular protein complex disassembly (GO:0043624)3.15756014
92anatomical structure regression (GO:0060033)3.15679406
93negative regulation of catenin import into nucleus (GO:0035414)3.15353430
94regulation of establishment of planar polarity (GO:0090175)3.13587445
95lung-associated mesenchyme development (GO:0060484)3.11502964
96mesenchymal cell proliferation (GO:0010463)3.11287262
97positive regulation of epithelial to mesenchymal transition (GO:0010718)3.08130369
98cartilage development involved in endochondral bone morphogenesis (GO:0060351)3.08044016
99macromolecular complex disassembly (GO:0032984)3.08027669
100establishment of apical/basal cell polarity (GO:0035089)3.07465381
101UV protection (GO:0009650)3.06887426
102DNA topological change (GO:0006265)3.03017947
103protein localization to endoplasmic reticulum (GO:0070972)3.03002293
104hematopoietic stem cell proliferation (GO:0071425)3.02360570
105establishment of protein localization to endoplasmic reticulum (GO:0072599)3.01987083
106somite development (GO:0061053)3.01510711
107imidazole-containing compound metabolic process (GO:0052803)3.00970672
108regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.00934322
109convergent extension (GO:0060026)2.99370657
110seminiferous tubule development (GO:0072520)2.98904966
111mesenchyme morphogenesis (GO:0072132)2.98903260
112virion attachment to host cell (GO:0019062)2.98676347
113adhesion of symbiont to host cell (GO:0044650)2.98676347
114embryonic cranial skeleton morphogenesis (GO:0048701)2.98639134
115peptidyl-arginine omega-N-methylation (GO:0035247)2.97817116
116lateral sprouting from an epithelium (GO:0060601)2.96894751
117head development (GO:0060322)2.96621665
118trabecula formation (GO:0060343)2.94913949
119DNA unwinding involved in DNA replication (GO:0006268)2.93509396
120respiratory tube development (GO:0030323)2.92042398
121embryonic skeletal joint morphogenesis (GO:0060272)2.91310337
122mucosal-associated lymphoid tissue development (GO:0048537)2.91001315
123Peyers patch development (GO:0048541)2.91001315
124peptidyl-proline hydroxylation (GO:0019511)2.90761232
125mesenchyme development (GO:0060485)2.87404274
126urogenital system development (GO:0001655)2.86730728
127aggressive behavior (GO:0002118)2.86085201
128neuronal stem cell maintenance (GO:0097150)2.85410051
129postsynaptic membrane organization (GO:0001941)2.85304321
130extracellular matrix organization (GO:0030198)2.84541633
131extracellular structure organization (GO:0043062)2.84538906
132cranial suture morphogenesis (GO:0060363)2.84400837
1333-UTR-mediated mRNA stabilization (GO:0070935)2.83647647
134cellular response to vitamin D (GO:0071305)2.83291438
135cochlea morphogenesis (GO:0090103)2.82687615
136mesenchymal to epithelial transition (GO:0060231)2.82199516
137histone H3-K9 methylation (GO:0051567)2.81912772
138cranial nerve morphogenesis (GO:0021602)2.77397721
139vitamin A metabolic process (GO:0006776)2.75942100
140translational initiation (GO:0006413)2.75522369
141deoxyribonucleotide catabolic process (GO:0009264)2.75022278
142endocardial cushion morphogenesis (GO:0003203)2.72943084
143adhesion of symbiont to host (GO:0044406)2.72095434
144positive regulation of cartilage development (GO:0061036)2.71779945
145cell proliferation in forebrain (GO:0021846)2.71726738
146regulation of cartilage development (GO:0061035)2.70870988
147regulation of heart morphogenesis (GO:2000826)2.70727897
148hippo signaling (GO:0035329)2.70724086
149digestive tract morphogenesis (GO:0048546)2.68197013
150protein retention in ER lumen (GO:0006621)2.68194875
151negative regulation of cell fate specification (GO:0009996)2.67844493
152organ induction (GO:0001759)2.67186514
153regulation of non-canonical Wnt signaling pathway (GO:2000050)2.67185199
154establishment of integrated proviral latency (GO:0075713)2.67008126
155endothelial cell morphogenesis (GO:0001886)2.66346333
156negative regulation of B cell apoptotic process (GO:0002903)2.65508599
157peptidyl-arginine N-methylation (GO:0035246)2.65454222
158peptidyl-arginine methylation (GO:0018216)2.65454222
159lens fiber cell development (GO:0070307)2.63624599
160purine deoxyribonucleotide catabolic process (GO:0009155)2.62906049
161protein trimerization (GO:0070206)2.62845412
162protein hydroxylation (GO:0018126)2.62838626
163mesonephros development (GO:0001823)2.62799710
164face morphogenesis (GO:0060325)2.62317721
165epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.62147398
166positive regulation of neuroblast proliferation (GO:0002052)2.61821415
167establishment or maintenance of monopolar cell polarity (GO:0061339)2.61638952
168establishment of monopolar cell polarity (GO:0061162)2.61638952
169chondrocyte development (GO:0002063)2.61413017
170anterior/posterior axis specification, embryo (GO:0008595)2.60840001
171positive regulation of odontogenesis (GO:0042482)2.59977397
172regulation of chondrocyte differentiation (GO:0032330)2.59048447
173negative regulation of fatty acid transport (GO:2000192)2.58543543
174hematopoietic stem cell differentiation (GO:0060218)2.58379612
175histone H4 deacetylation (GO:0070933)2.57559194
176negative regulation of mRNA metabolic process (GO:1903312)2.57049310
177cell migration in hindbrain (GO:0021535)2.55651190
178positive regulation of gastrulation (GO:2000543)2.55190325
179negative regulation of gene expression, epigenetic (GO:0045814)2.55087616
180DNA strand elongation involved in DNA replication (GO:0006271)2.53994206
181ribosomal small subunit biogenesis (GO:0042274)2.53104475
182histone H3 deacetylation (GO:0070932)2.51854266
183regulation of cell fate specification (GO:0042659)2.50209111
184presynaptic membrane assembly (GO:0097105)2.49353550
185histone arginine methylation (GO:0034969)2.46942330

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.72729219
2TRIM28_21343339_ChIP-Seq_HEK293_Human5.41386439
3EZH2_22144423_ChIP-Seq_EOC_Human3.87158689
4RARG_19884340_ChIP-ChIP_MEFs_Mouse3.70286293
5BP1_19119308_ChIP-ChIP_Hs578T_Human3.57552377
6PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.46957536
7CLOCK_20551151_ChIP-Seq_293T_Human3.22129244
8RBPJ_22232070_ChIP-Seq_NCS_Mouse3.01611353
9E2F7_22180533_ChIP-Seq_HELA_Human2.97979764
10KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.72308718
11KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.72308718
12KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.72308718
13VDR_21846776_ChIP-Seq_THP-1_Human2.72157852
14TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.59348728
15TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.57419481
16NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.51047522
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.46688948
18RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.46266479
19* ZFP281_18757296_ChIP-ChIP_E14_Mouse2.26036355
20CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.23241837
21WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.15895955
22EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.15085451
23EGR1_19374776_ChIP-ChIP_THP-1_Human2.04850384
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.02890999
25MYC_22102868_ChIP-Seq_BL_Human2.01796247
26HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.99224003
27TP53_20018659_ChIP-ChIP_R1E_Mouse1.93276444
28SCL_19346495_ChIP-Seq_HPC-7_Human1.89515688
29ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.88528867
30ELK3_25401928_ChIP-Seq_HUVEC_Human1.87978925
31MYC_18358816_ChIP-ChIP_MESCs_Mouse1.85400480
32NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.85192704
33HIF1A_21447827_ChIP-Seq_MCF-7_Human1.84620919
34TCF3_18692474_ChIP-Seq_MEFs_Mouse1.83498079
35SOX2_16153702_ChIP-ChIP_HESCs_Human1.83243339
36ESR1_21235772_ChIP-Seq_MCF-7_Human1.80420152
37POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.79230727
38XRN2_22483619_ChIP-Seq_HELA_Human1.78673169
39CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.75545096
40TP63_19390658_ChIP-ChIP_HaCaT_Human1.73429892
41CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.72595975
42CIITA_25753668_ChIP-Seq_RAJI_Human1.72543428
43ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.72361004
44WT1_19549856_ChIP-ChIP_CCG9911_Human1.70996639
45PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.68915456
46CJUN_26792858_Chip-Seq_BT549_Human1.60185436
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.59351775
48HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.55841072
49BRD4_25478319_ChIP-Seq_HGPS_Human1.54327823
50CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.53849431
51MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.53821765
52SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.53801470
53ERG_21242973_ChIP-ChIP_JURKAT_Human1.52844850
54ESR1_15608294_ChIP-ChIP_MCF-7_Human1.52114619
55ZFP281_27345836_Chip-Seq_ESCs_Mouse1.49188435
56TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.48661117
57UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.48204510
58HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.47578524
59TTF2_22483619_ChIP-Seq_HELA_Human1.43764328
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.43683515
61EED_16625203_ChIP-ChIP_MESCs_Mouse1.42512052
62SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.42420856
63TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42230970
64NANOG_21062744_ChIP-ChIP_HESCs_Human1.42185682
65MYC_19079543_ChIP-ChIP_MESCs_Mouse1.41671002
66CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.40318410
67EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.38684864
68KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34211874
69SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33902495
70IGF1R_20145208_ChIP-Seq_DFB_Human1.33636656
71OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.32530116
72CTCF_18555785_ChIP-Seq_MESCs_Mouse1.32280956
73* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.31093053
74ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.30757201
75KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.30058661
76KDM2B_26808549_Chip-Seq_DND41_Human1.28150683
77IRF1_19129219_ChIP-ChIP_H3396_Human1.26849590
78IKZF1_21737484_ChIP-ChIP_HCT116_Human1.26759134
79STAT3_1855785_ChIP-Seq_MESCs_Mouse1.26266311
80EP300_21415370_ChIP-Seq_HL-1_Mouse1.25545330
81DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.25400515
82EZH2_27304074_Chip-Seq_ESCs_Mouse1.23618508
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.23555896
84AR_21909140_ChIP-Seq_LNCAP_Human1.23153966
85SOX3_22085726_ChIP-Seq_NPCs_Mouse1.22665067
86NANOG_16153702_ChIP-ChIP_HESCs_Human1.22572642
87RACK7_27058665_Chip-Seq_MCF-7_Human1.22298382
88YY1_21170310_ChIP-Seq_MESCs_Mouse1.21411404
89PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.20630368
90P300_27058665_Chip-Seq_ZR-75-30cells_Human1.20039359
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.19751467
92ISL1_27105846_Chip-Seq_CPCs_Mouse1.19678585
93UBF1/2_26484160_Chip-Seq_HMECs_Human1.19091823
94STAT6_21828071_ChIP-Seq_BEAS2B_Human1.16738924
95TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.16723793
96FOXP1_21924763_ChIP-Seq_HESCs_Human1.15687982
97CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.15073865
98EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.14905282
99SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14189325
100SA1_27219007_Chip-Seq_ERYTHROID_Human1.14113756
101LXR_22292898_ChIP-Seq_THP-1_Human1.13877045
102TP53_22127205_ChIP-Seq_IMR90_Human1.12855394
103ATF3_27146783_Chip-Seq_COLON_Human1.12365345
104STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.12113692
105P68_20966046_ChIP-Seq_HELA_Human1.11621004
106E2F4_17652178_ChIP-ChIP_JURKAT_Human1.11327784
107KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.09952924
108E2F1_18555785_ChIP-Seq_MESCs_Mouse1.09780702
109THAP11_20581084_ChIP-Seq_MESCs_Mouse1.09385231
110UTX_26944678_Chip-Seq_JUKART_Human1.08752629
111SMC1_22415368_ChIP-Seq_MEFs_Mouse1.08364793
112* ELF1_20517297_ChIP-Seq_JURKAT_Human1.07973365
113VDR_24763502_ChIP-Seq_THP-1_Human1.07548284
114ESR2_21235772_ChIP-Seq_MCF-7_Human1.07522774
115YY1_22570637_ChIP-Seq_MALME-3M_Human1.07503504
116TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.05676530
117SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.05342647
118EZH2_18974828_ChIP-Seq_MESCs_Mouse1.05030167
119RNF2_18974828_ChIP-Seq_MESCs_Mouse1.05030167
120SOX2_18555785_ChIP-Seq_MESCs_Mouse1.04691395
121TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.04643838
122TCF3_18692474_ChIP-Seq_MESCs_Mouse1.04207543
123POU5F1_16153702_ChIP-ChIP_HESCs_Human1.03642576
124MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.03460550
125ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02664518
126DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02636863
127NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01994666
128TCF7_22412390_ChIP-Seq_EML_Mouse1.01090325
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.00979851
130CTCF_26484167_Chip-Seq_Bcells_Mouse1.00826779
131ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.00468330
132NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00392125
133JARID2_20064375_ChIP-Seq_MESCs_Mouse1.00233946
134POU5F1_16518401_ChIP-PET_MESCs_Mouse0.99748485
135FOXM1_23109430_ChIP-Seq_U2OS_Human0.99678690
136NFIB_24661679_ChIP-Seq_LUNG_Mouse0.99137937
137RING1B_27294783_Chip-Seq_ESCs_Mouse0.98504036
138CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.98464748
139CBX2_27304074_Chip-Seq_ESCs_Mouse0.98000194
140* KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96765501
141GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96595516
142CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96541918
143SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96131735
144ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95969902
145MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.95145136
146RNF2_27304074_Chip-Seq_ESCs_Mouse0.94547958
147SMC3_22415368_ChIP-Seq_MEFs_Mouse0.94072909
148RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.93792152
149CTCF_27219007_Chip-Seq_Bcells_Human0.93478906
150NELFA_20434984_ChIP-Seq_ESCs_Mouse0.93284446
151TET1_21451524_ChIP-Seq_MESCs_Mouse0.93237890
152FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.91631789
153TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90431269
154NANOG_18692474_ChIP-Seq_MEFs_Mouse0.90055571
155SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.90055045
156TCF3_18347094_ChIP-ChIP_MESCs_Mouse0.89817557
157SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.89697141

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.50699634
2MP0005503_abnormal_tendon_morphology5.69207174
3MP0005275_abnormal_skin_tensile5.50801935
4MP0003705_abnormal_hypodermis_morpholog3.52992312
5MP0005171_absent_coat_pigmentation3.40502417
6MP0006292_abnormal_olfactory_placode3.39926810
7MP0001958_emphysema2.88625328
8MP0004272_abnormal_basement_membrane2.84042269
9MP0000566_synostosis2.74509673
10MP0003279_aneurysm2.71270778
11MP0006054_spinal_hemorrhage2.68286152
12MP0005499_abnormal_olfactory_system2.55451571
13MP0005394_taste/olfaction_phenotype2.55451571
14MP0002653_abnormal_ependyma_morphology2.49533508
15MP0010030_abnormal_orbit_morphology2.38127918
16MP0008789_abnormal_olfactory_epithelium2.36005937
17MP0005508_abnormal_skeleton_morphology2.31558310
18MP0003136_yellow_coat_color2.22819216
19MP0003941_abnormal_skin_development2.18796768
20MP0003385_abnormal_body_wall2.03698687
21MP0005257_abnormal_intraocular_pressure2.02042553
22MP0002249_abnormal_larynx_morphology1.95085396
23MP0002282_abnormal_trachea_morphology1.92897466
24MP0002060_abnormal_skin_morphology1.91717090
25MP0009250_abnormal_appendicular_skeleto1.90709054
26MP0003942_abnormal_urinary_system1.90479334
27MP0002108_abnormal_muscle_morphology1.85077480
28MP0005397_hematopoietic_system_phenotyp1.81712986
29MP0001545_abnormal_hematopoietic_system1.81712986
30MP0003115_abnormal_respiratory_system1.79188926
31MP0000534_abnormal_ureter_morphology1.74282080
32MP0009053_abnormal_anal_canal1.72703572
33MP0000778_abnormal_nervous_system1.72211204
34MP0000372_irregular_coat_pigmentation1.70729202
35MP0009384_cardiac_valve_regurgitation1.64089510
36MP0005623_abnormal_meninges_morphology1.59597877
37MP0001542_abnormal_bone_strength1.57659703
38MP0005075_abnormal_melanosome_morpholog1.56265776
39MP0005023_abnormal_wound_healing1.55251756
40MP0006276_abnormal_autonomic_nervous1.52893591
41MP0000049_abnormal_middle_ear1.47960851
42MP0002932_abnormal_joint_morphology1.45688008
43MP0003122_maternal_imprinting1.45600925
44MP0003566_abnormal_cell_adhesion1.44227897
45MP0002396_abnormal_hematopoietic_system1.42981923
46MP0000428_abnormal_craniofacial_morphol1.42597600
47MP0004808_abnormal_hematopoietic_stem1.40392513
48MP0003123_paternal_imprinting1.39830316
49MP0010368_abnormal_lymphatic_system1.38597677
50MP0000516_abnormal_urinary_system1.34135552
51MP0005367_renal/urinary_system_phenotyp1.34135552
52MP0000465_gastrointestinal_hemorrhage1.30548914
53MP0001243_abnormal_dermal_layer1.28248075
54MP0005646_abnormal_pituitary_gland1.27540365
55MP0002896_abnormal_bone_mineralization1.26869383
56MP0002751_abnormal_autonomic_nervous1.26320477
57MP0000537_abnormal_urethra_morphology1.25953881
58MP0000751_myopathy1.25073073
59MP0001984_abnormal_olfaction1.22910094
60MP0008995_early_reproductive_senescence1.22738789
61MP0000733_abnormal_muscle_development1.21551289
62MP0000163_abnormal_cartilage_morphology1.20938107
63MP0003787_abnormal_imprinting1.20867267
64MP0002295_abnormal_pulmonary_circulatio1.19504872
65MP0002115_abnormal_skeleton_extremities1.16908868
66MP0004134_abnormal_chest_morphology1.16767394
67MP0000762_abnormal_tongue_morphology1.15327452
68MP0003935_abnormal_craniofacial_develop1.12748480
69MP0005390_skeleton_phenotype1.11392257
70MP0002822_catalepsy1.09576647
71MP0003755_abnormal_palate_morphology1.09564024
72MP0008932_abnormal_embryonic_tissue1.09273252
73MP0002089_abnormal_postnatal_growth/wei1.08841332
74MP0001286_abnormal_eye_development1.07217157
75MP0000767_abnormal_smooth_muscle1.06149268
76MP0005248_abnormal_Harderian_gland1.06146090
77MP0002116_abnormal_craniofacial_bone1.04767672
78MP0000631_abnormal_neuroendocrine_gland1.03681193
79MP0002109_abnormal_limb_morphology1.03513481
80MP0005377_hearing/vestibular/ear_phenot1.00938376
81MP0003878_abnormal_ear_physiology1.00938376
82MP0003861_abnormal_nervous_system1.00871074
83MP0002233_abnormal_nose_morphology0.99330377
84MP0002111_abnormal_tail_morphology0.98985421
85MP0002697_abnormal_eye_size0.98305814
86MP0003937_abnormal_limbs/digits/tail_de0.98129998
87MP0010352_gastrointestinal_tract_polyps0.97981804
88MP0002113_abnormal_skeleton_development0.97652323
89MP0010094_abnormal_chromosome_stability0.96953071
90MP0000432_abnormal_head_morphology0.96908232
91MP0002938_white_spotting0.94064430
92MP0002114_abnormal_axial_skeleton0.92847050
93MP0002735_abnormal_chemical_nociception0.91458529
94MP0001879_abnormal_lymphatic_vessel0.90109395
95MP0003119_abnormal_digestive_system0.87379298
96MP0001175_abnormal_lung_morphology0.87186707
97MP0005670_abnormal_white_adipose0.86988565
98MP0005220_abnormal_exocrine_pancreas0.85682859
99MP0005391_vision/eye_phenotype0.85332808
100MP0004858_abnormal_nervous_system0.85056529
101MP0001849_ear_inflammation0.84506958
102MP0003283_abnormal_digestive_organ0.83803214
103MP0000467_abnormal_esophagus_morphology0.83619481
104MP0000026_abnormal_inner_ear0.83276226
105MP0004185_abnormal_adipocyte_glucose0.83171647
106MP0005076_abnormal_cell_differentiation0.82546703
107MP0004197_abnormal_fetal_growth/weight/0.82514199
108MP0003567_abnormal_fetal_cardiomyocyte0.81318369
109MP0003111_abnormal_nucleus_morphology0.81185769
110MP0009379_abnormal_foot_pigmentation0.81108139
111MP0000750_abnormal_muscle_regeneration0.79190742
112MP0008058_abnormal_DNA_repair0.79130141
113MP0001529_abnormal_vocalization0.78113022
114MP0009697_abnormal_copulation0.76855966
115MP0002092_abnormal_eye_morphology0.76200786
116MP0001293_anophthalmia0.76074668
117MP0002009_preneoplasia0.75056224
118MP0005197_abnormal_uvea_morphology0.74397504
119MP0001299_abnormal_eye_distance/0.73739300
120MP0004133_heterotaxia0.73675753
121MP0002152_abnormal_brain_morphology0.72516825
122MP0001614_abnormal_blood_vessel0.72355485
123MP0003948_abnormal_gas_homeostasis0.72165496
124MP0003315_abnormal_perineum_morphology0.71519316
125MP0009278_abnormal_bone_marrow0.71162707
126MP0002128_abnormal_blood_circulation0.71069739
127MP0002081_perinatal_lethality0.70974643
128MP0003121_genomic_imprinting0.70458346
129MP0001915_intracranial_hemorrhage0.70333918
130MP0009672_abnormal_birth_weight0.70092382
131MP0000955_abnormal_spinal_cord0.69976240
132MP0002925_abnormal_cardiovascular_devel0.69647249
133MP0005645_abnormal_hypothalamus_physiol0.69260311
134MP0005193_abnormal_anterior_eye0.68532167
135MP0000579_abnormal_nail_morphology0.67780606
136MP0002998_abnormal_bone_remodeling0.67546964
137MP0000343_altered_response_to0.66474471
138MP0006138_congestive_heart_failure0.65590506
139MP0003938_abnormal_ear_development0.65564189
140MP0002085_abnormal_embryonic_tissue0.65435560
141MP0008007_abnormal_cellular_replicative0.63287757
142MP0000462_abnormal_digestive_system0.62665331
143MP0002084_abnormal_developmental_patter0.62611888
144MP0002177_abnormal_outer_ear0.62591243
145MP0001348_abnormal_lacrimal_gland0.60778329
146MP0003795_abnormal_bone_structure0.60703467
147MP0005369_muscle_phenotype0.60305523
148MP0002133_abnormal_respiratory_system0.60208907

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.60102474
2Premature rupture of membranes (HP:0001788)6.14355986
3Ankle contracture (HP:0006466)5.18060154
4Broad metatarsal (HP:0001783)4.92068130
5Aortic dissection (HP:0002647)4.66149173
6Soft skin (HP:0000977)4.54271882
7Shallow orbits (HP:0000586)4.43691200
8Vitreoretinal degeneration (HP:0000655)4.35280854
9Bladder diverticulum (HP:0000015)4.19805061
10Atrophic scars (HP:0001075)4.10105892
11High anterior hairline (HP:0009890)3.75572816
12Abnormality of dentin (HP:0010299)3.69444780
13Follicular hyperkeratosis (HP:0007502)3.65256045
14Aortic aneurysm (HP:0004942)3.61492835
15Cervical subluxation (HP:0003308)3.61142673
16Biconcave vertebral bodies (HP:0004586)3.61040997
17Cerebral aneurysm (HP:0004944)3.54260829
18Vertebral compression fractures (HP:0002953)3.52248321
19Wrist flexion contracture (HP:0001239)3.46535669
20Fragile skin (HP:0001030)3.32871576
21Blue sclerae (HP:0000592)3.32014242
22Dilatation of the ascending aorta (HP:0005111)3.30042448
23Neonatal short-limb short stature (HP:0008921)3.29851368
24Trigonocephaly (HP:0000243)3.24495261
25Type 1 muscle fiber predominance (HP:0003803)3.23121967
26Acute lymphatic leukemia (HP:0006721)3.22020177
27Wormian bones (HP:0002645)3.13407033
28Mitral valve prolapse (HP:0001634)3.09209876
29Reticulocytopenia (HP:0001896)3.02384719
30Broad thumb (HP:0011304)3.01433160
31Rib fusion (HP:0000902)2.98658104
32Genu recurvatum (HP:0002816)2.93530417
33Peritonitis (HP:0002586)2.93064938
34Turricephaly (HP:0000262)2.91954995
35Renal duplication (HP:0000075)2.88699085
36Broad phalanges of the hand (HP:0009768)2.87323581
37Bowel diverticulosis (HP:0005222)2.85493769
38Short 4th metacarpal (HP:0010044)2.75347392
39Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.75347392
40Abnormality of cells of the erythroid lineage (HP:0012130)2.74286977
41Hyperextensible skin (HP:0000974)2.73406869
42Spinal rigidity (HP:0003306)2.69554377
43Absent epiphyses (HP:0010577)2.69191803
44Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.69191803
45Failure to thrive in infancy (HP:0001531)2.66725590
46Broad phalanx (HP:0006009)2.66420988
47Colon cancer (HP:0003003)2.66050676
48Broad finger (HP:0001500)2.64921268
49Hypoplastic ischia (HP:0003175)2.63522289
50Abnormal number of erythroid precursors (HP:0012131)2.61164727
51Wide anterior fontanel (HP:0000260)2.59872595
52Increased connective tissue (HP:0009025)2.57185100
53Abnormality of the phalanges of the 2nd finger (HP:0009541)2.54063003
54Agammaglobulinemia (HP:0004432)2.51339076
55Joint laxity (HP:0001388)2.48612143
56Abnormality of the ischium (HP:0003174)2.44048760
57Flat cornea (HP:0007720)2.41476561
58Breech presentation (HP:0001623)2.41352970
59Slender build (HP:0001533)2.39995300
60Broad distal phalanx of finger (HP:0009836)2.39111201
61Vascular tortuosity (HP:0004948)2.37200816
62Round ear (HP:0100830)2.37197335
63Abnormality of the 4th metacarpal (HP:0010012)2.36739353
64Abnormality of the acetabulum (HP:0003170)2.33347343
65Abnormal delivery (HP:0001787)2.30390704
66Deviation of the hallux (HP:0010051)2.30098663
67Cutaneous syndactyly (HP:0012725)2.28541122
68Morphological abnormality of the middle ear (HP:0008609)2.27709981
69Striae distensae (HP:0001065)2.25729293
70Camptodactyly of toe (HP:0001836)2.24749366
71Calcaneovalgus deformity (HP:0001848)2.24637336
72Anteriorly placed anus (HP:0001545)2.23196441
73Cutaneous finger syndactyly (HP:0010554)2.23013477
74Thin ribs (HP:0000883)2.22311225
75Irregular epiphyses (HP:0010582)2.22293129
76Arterial tortuosity (HP:0005116)2.21247928
77Metaphyseal cupping (HP:0003021)2.19159088
78Bell-shaped thorax (HP:0001591)2.17857358
79White forelock (HP:0002211)2.16806906
80Hallux valgus (HP:0001822)2.16582315
81Renovascular hypertension (HP:0100817)2.16484179
82Overgrowth (HP:0001548)2.16137122
83Septo-optic dysplasia (HP:0100842)2.13919112
84Abnormality of the diencephalon (HP:0010662)2.13716973
85Broad palm (HP:0001169)2.13424973
86Abnormality of the aortic arch (HP:0012303)2.13064583
87Inguinal hernia (HP:0000023)2.11606545
88Selective tooth agenesis (HP:0001592)2.10722615
89Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.09887425
90Broad long bones (HP:0005622)2.07301110
91Alopecia of scalp (HP:0002293)2.07064399
92Narrow nasal bridge (HP:0000446)2.05556426
93Deformed tarsal bones (HP:0008119)2.04861465
94Osteoarthritis (HP:0002758)2.04832937
95Short 5th finger (HP:0009237)2.04086497
96Supernumerary ribs (HP:0005815)2.02937888
97Hyperacusis (HP:0010780)2.02059382
98Heterochromia iridis (HP:0001100)2.00741080
99Elbow flexion contracture (HP:0002987)2.00646584
100Aneurysm (HP:0002617)1.99849486
101Megalocornea (HP:0000485)1.99591283
102Aortic regurgitation (HP:0001659)1.99068107
103Partial duplication of the phalanx of hand (HP:0009999)1.98628075
104Pulmonary artery stenosis (HP:0004415)1.98052415
105Mitral regurgitation (HP:0001653)1.97961279
106Hypoplasia of the iris (HP:0007676)1.97934815
107Decreased skull ossification (HP:0004331)1.97782538
108Coronal craniosynostosis (HP:0004440)1.95825642
109Delayed cranial suture closure (HP:0000270)1.95733908
110Broad ribs (HP:0000885)1.95171269
111Spondylolisthesis (HP:0003302)1.94807438
112Increased variability in muscle fiber diameter (HP:0003557)1.94786939
113Flat capital femoral epiphysis (HP:0003370)1.91929568
114Hypotelorism (HP:0000601)1.91278843
115Generalized hypotonia (HP:0001290)1.91148449
116Panhypogammaglobulinemia (HP:0003139)1.91127057
117Mesomelia (HP:0003027)1.90935287
118Thin bony cortex (HP:0002753)1.90809908
119Morphological abnormality of the inner ear (HP:0011390)1.90206989
120Broad hallux (HP:0010055)1.89887591
121Abnormality of the intervertebral disk (HP:0005108)1.89845972
122Anophthalmia (HP:0000528)1.89459507
123Ulnar bowing (HP:0003031)1.89057838
124Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.88517004
125Supernumerary bones of the axial skeleton (HP:0009144)1.88322159
126Abdominal situs inversus (HP:0003363)1.87697828
127Abnormality of abdominal situs (HP:0011620)1.87697828
128Hip contracture (HP:0003273)1.87179825
129Mildly elevated creatine phosphokinase (HP:0008180)1.86116816
130Thoracic kyphosis (HP:0002942)1.85776240
131Ectopia lentis (HP:0001083)1.85501101
132Venous insufficiency (HP:0005293)1.84093827
133Broad toe (HP:0001837)1.83209071
134Abnormality of the pubic bones (HP:0003172)1.82058104
135Asymmetry of the thorax (HP:0001555)1.81936515
136Partial duplication of thumb phalanx (HP:0009944)1.81639898
137Hyperglycinemia (HP:0002154)1.80095487
138Synostosis of carpal bones (HP:0005048)1.79918975
139Hepatoblastoma (HP:0002884)1.79793405
140Delayed closure of the anterior fontanelle (HP:0001476)1.79752247
141Abnormality of the peritoneum (HP:0002585)1.79463804
142Aortic valve stenosis (HP:0001650)1.78612764
143Abnormality of the parietal bone (HP:0002696)1.78206508
144Lymphangioma (HP:0100764)1.78051338
145Osteopenia (HP:0000938)1.77805191
146Occipital encephalocele (HP:0002085)1.77324687
147Tarsal synostosis (HP:0008368)1.77285812
148Abnormality of the calcaneus (HP:0008364)1.76747447
149Depressed nasal ridge (HP:0000457)1.76481576
150Abnormality of skeletal muscle fiber size (HP:0012084)1.75502886
151Mild short stature (HP:0003502)1.74781369
152Sprengel anomaly (HP:0000912)1.74731533
153Partial agenesis of the corpus callosum (HP:0001338)1.74593860
154Alacrima (HP:0000522)1.74201998
155Congenital diaphragmatic hernia (HP:0000776)1.73896732
156Abnormality of skull ossification (HP:0002703)1.73518200
157Osteolytic defects of the hand bones (HP:0009699)1.73450549
158Osteolytic defects of the phalanges of the hand (HP:0009771)1.73450549
159Knee flexion contracture (HP:0006380)1.73263770
160Flexion contracture of toe (HP:0005830)1.73062587
161Joint contractures involving the joints of the feet (HP:0100492)1.73062587
162Epiphyseal dysplasia (HP:0002656)1.72508428
163Annular pancreas (HP:0001734)1.71292282
164Tracheomalacia (HP:0002779)1.71243785
165Nephronophthisis (HP:0000090)1.70831525
166Renal hypoplasia (HP:0000089)1.70701997
167Venous abnormality (HP:0002624)1.69168420
168Patellar aplasia (HP:0006443)1.69162375
169Oligodactyly (HP:0012165)1.68242660
170Disproportionate tall stature (HP:0001519)1.67676491
171Wide cranial sutures (HP:0010537)1.67466665
172Generalized amyotrophy (HP:0003700)1.67196518
173Short middle phalanx of the 5th finger (HP:0004220)1.67166998
174Fibular hypoplasia (HP:0003038)1.67002186
175Pointed chin (HP:0000307)1.66672086
176Overriding aorta (HP:0002623)1.64253051
177Patchy hypopigmentation of hair (HP:0011365)1.63129301
178Coarctation of aorta (HP:0001680)1.61596712
179Synostosis involving the elbow (HP:0003938)1.61591543
180Humeroradial synostosis (HP:0003041)1.61591543
181Preaxial foot polydactyly (HP:0001841)1.60422117

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR24.55501578
2TRIB34.39565962
3PDGFRA3.66736663
4BCKDK3.66203864
5EPHB23.12973872
6VRK22.92297377
7LATS22.66510981
8PKN22.61308955
9TGFBR22.45732689
10LATS12.33926377
11TTN2.30043708
12CDK192.20889801
13TGFBR12.15229231
14PAK42.10543263
15MAPK152.04269782
16EPHA31.97876454
17ERN11.96749815
18SIK11.90252482
19MAP4K21.87346853
20DYRK21.85251278
21MYLK1.78435156
22FGFR21.77622001
23VRK11.72449827
24ACVR1B1.67984488
25BUB11.64376971
26PLK41.62390616
27SRPK11.58100475
28PAK21.56718588
29FES1.54584737
30RIPK11.52428903
31TIE11.50145295
32MKNK21.43517065
33FGFR11.42595343
34TESK11.42531961
35FER1.40299317
36CDC71.38118477
37MET1.34097912
38DYRK1B1.32440164
39DYRK31.32313094
40ILK1.30660555
41LRRK21.28854115
42TESK21.28113359
43PDK31.26455784
44PDK41.26455784
45ICK1.25688119
46EPHA21.22798329
47PTK21.20668321
48PRKD31.20624578
49MAP3K111.19978129
50RPS6KA41.17784150
51CDK121.17375422
52PTK61.13095979
53ATR1.12861056
54CSNK1G31.12666067
55MAP3K61.11974114
56NEK91.11435320
57NEK21.10425923
58PDGFRB1.10190327
59FLT31.09206838
60WEE11.08932019
61CDK71.05892673
62MTOR1.05066812
63TNK21.03498288
64NTRK21.00514873
65LIMK11.00085131
66TRIM280.97448683
67ERBB30.96227023
68MAP2K70.95873210
69MAP3K100.95509439
70DYRK1A0.94451339
71BMX0.93796878
72MKNK10.90546624
73MAP4K10.89869046
74EEF2K0.88891889
75CSNK1G20.88688534
76PTK2B0.87522440
77RPS6KL10.87519336
78RPS6KC10.87519336
79CSNK1A1L0.84565936
80STK30.84409126
81BTK0.84085526
82SCYL20.80957928
83PASK0.80866131
84CSNK1G10.80123754
85CSF1R0.79433318
86MAP3K30.78218884
87TYRO30.77082205
88CHEK20.76964589
89RPS6KB20.76867316
90CDK40.76599641
91LMTK20.76578668
92NTRK10.75923929
93RPS6KA60.73381251
94CAMK1D0.70719152
95UHMK10.70413007
96CDC42BPA0.69997891
97MAP3K40.69603366
98MARK20.69505329
99BRD40.68197558
100DMPK0.67984172
101CDK90.66639580
102MAP2K40.66351467
103NUAK10.65668824
104PIK3CA0.65630592
105CDK20.64182615
106PAK10.62879442
107ROCK10.62034823
108STK38L0.61440890
109ZAK0.61302325
110CDK11A0.61293220
111RET0.59903578
112TAOK20.58246820
113MAPK30.57824311
114ROCK20.57135761
115KSR10.55976844
116PDK20.55964712
117NEK10.55942814
118PAK30.55727813
119TTK0.54626048
120CDK80.52753440
121EPHA40.52598245
122MAP2K10.51044364
123TSSK60.50763090
124CDK30.50545428
125CHEK10.49624725
126RPS6KA20.49588264
127FGFR40.48504485
128RPS6KA50.48031972
129CDK150.47744452
130MAP3K70.47418847
131NME10.46193275
132AKT10.45805280
133PLK10.45210345
134KDR0.45161488
135MAP3K80.44801092
136MATK0.44754080
137PIM20.43806585
138MAPK70.43792807
139ATM0.43539584
140ERBB20.43357490
141PLK30.43115914
142MAPKAPK30.42633218
143TEC0.42237728
144CDK180.41706339
145CLK10.40975352
146CDK60.40781796
147AKT20.40051492
148FGFR30.39948635
149PRKCI0.38262016
150MAPK10.36688497
151GSK3A0.35265541
152MAPKAPK20.32704208
153INSR0.32065417
154SRC0.32029475
155KIT0.31220431
156MAP2K20.28107790
157AURKB0.27945363
158PLK20.27407489
159CAMK40.25673965
160PHKG10.25177245
161PHKG20.25177245

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.26378928
2Basal cell carcinoma_Homo sapiens_hsa052173.21343933
3Hedgehog signaling pathway_Homo sapiens_hsa043402.88525276
4Protein digestion and absorption_Homo sapiens_hsa049742.78423961
5Focal adhesion_Homo sapiens_hsa045102.70075351
6Hippo signaling pathway_Homo sapiens_hsa043902.32978779
7TGF-beta signaling pathway_Homo sapiens_hsa043502.28529149
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.22458257
9Other glycan degradation_Homo sapiens_hsa005112.13945379
10Asthma_Homo sapiens_hsa053102.09991823
11Proteoglycans in cancer_Homo sapiens_hsa052052.09895061
12DNA replication_Homo sapiens_hsa030301.97466846
13Fanconi anemia pathway_Homo sapiens_hsa034601.94545309
14AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.92184532
15Adherens junction_Homo sapiens_hsa045201.83273480
16Bladder cancer_Homo sapiens_hsa052191.82211217
17Mismatch repair_Homo sapiens_hsa034301.80351977
18Small cell lung cancer_Homo sapiens_hsa052221.78824834
19Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.76812679
20Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.74200163
21Amoebiasis_Homo sapiens_hsa051461.70874027
22Base excision repair_Homo sapiens_hsa034101.65987418
23Cell cycle_Homo sapiens_hsa041101.63067260
24Wnt signaling pathway_Homo sapiens_hsa043101.61390274
25MicroRNAs in cancer_Homo sapiens_hsa052061.56962585
26PI3K-Akt signaling pathway_Homo sapiens_hsa041511.53177469
27Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.47427374
28Non-homologous end-joining_Homo sapiens_hsa034501.47164437
29Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.46686017
30Pathways in cancer_Homo sapiens_hsa052001.43454407
31Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.41155291
32Notch signaling pathway_Homo sapiens_hsa043301.40633877
33Biosynthesis of amino acids_Homo sapiens_hsa012301.40616586
34Lysine degradation_Homo sapiens_hsa003101.36904683
35Pentose phosphate pathway_Homo sapiens_hsa000301.35944058
36Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.34016226
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.32337144
38Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.30437251
39HTLV-I infection_Homo sapiens_hsa051661.29992924
40Dilated cardiomyopathy_Homo sapiens_hsa054141.28288641
41Melanoma_Homo sapiens_hsa052181.25399830
42Spliceosome_Homo sapiens_hsa030401.24375799
432-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.23816240
44Colorectal cancer_Homo sapiens_hsa052101.23594099
45RNA transport_Homo sapiens_hsa030131.18646421
46Systemic lupus erythematosus_Homo sapiens_hsa053221.16360995
47Melanogenesis_Homo sapiens_hsa049161.16144504
48Chronic myeloid leukemia_Homo sapiens_hsa052201.15536345
49Malaria_Homo sapiens_hsa051441.14677251
50Nucleotide excision repair_Homo sapiens_hsa034201.14475501
51Pyrimidine metabolism_Homo sapiens_hsa002401.12823469
52p53 signaling pathway_Homo sapiens_hsa041151.08223569
53Alcoholism_Homo sapiens_hsa050341.07993738
54Prostate cancer_Homo sapiens_hsa052151.07989318
55Tight junction_Homo sapiens_hsa045301.03019687
56Carbon metabolism_Homo sapiens_hsa012000.99176694
57Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98079583
58Proteasome_Homo sapiens_hsa030500.97161433
59Renin-angiotensin system_Homo sapiens_hsa046140.94022448
60Thyroid cancer_Homo sapiens_hsa052160.93706668
61Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.93490888
62Regulation of actin cytoskeleton_Homo sapiens_hsa048100.92112650
63Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90658645
64Pancreatic cancer_Homo sapiens_hsa052120.90362592
65Ribosome_Homo sapiens_hsa030100.86457315
66Endometrial cancer_Homo sapiens_hsa052130.86023813
67Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.85939125
68Axon guidance_Homo sapiens_hsa043600.84966505
69Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.84636599
70Platelet activation_Homo sapiens_hsa046110.82198800
71RNA polymerase_Homo sapiens_hsa030200.82061750
72Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.81977106
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81677006
74HIF-1 signaling pathway_Homo sapiens_hsa040660.81642913
75Viral myocarditis_Homo sapiens_hsa054160.81605777
76Toxoplasmosis_Homo sapiens_hsa051450.81042483
77Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.79112855
78Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.77823311
79Rap1 signaling pathway_Homo sapiens_hsa040150.77516592
80Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.76548279
81Glioma_Homo sapiens_hsa052140.75836266
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.75048631
83Fatty acid metabolism_Homo sapiens_hsa012120.72081285
84Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.71462144
85Oocyte meiosis_Homo sapiens_hsa041140.71300486
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71129226
87Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.70030566
88RNA degradation_Homo sapiens_hsa030180.69737843
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69227735
90Estrogen signaling pathway_Homo sapiens_hsa049150.65871202
91N-Glycan biosynthesis_Homo sapiens_hsa005100.65515078
92Purine metabolism_Homo sapiens_hsa002300.65507597
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.65156276
94Gap junction_Homo sapiens_hsa045400.64375079
95Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.64292499
96Prion diseases_Homo sapiens_hsa050200.63131180
97mRNA surveillance pathway_Homo sapiens_hsa030150.62182586
98Shigellosis_Homo sapiens_hsa051310.61424414
99Peroxisome_Homo sapiens_hsa041460.61352095
100Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.60445675
101Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60346679
102Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59674512
103Renal cell carcinoma_Homo sapiens_hsa052110.58928184
104Arachidonic acid metabolism_Homo sapiens_hsa005900.58076022
105Viral carcinogenesis_Homo sapiens_hsa052030.57876572
106Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.57243169
107Primary immunodeficiency_Homo sapiens_hsa053400.56354505
108Insulin resistance_Homo sapiens_hsa049310.56010105
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.55548967
110Longevity regulating pathway - mammal_Homo sapiens_hsa042110.55021984
111Fatty acid elongation_Homo sapiens_hsa000620.54968040
112mTOR signaling pathway_Homo sapiens_hsa041500.52437458
113AMPK signaling pathway_Homo sapiens_hsa041520.51078443
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.50963220
115Acute myeloid leukemia_Homo sapiens_hsa052210.49558973
116Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.48994210
117Apoptosis_Homo sapiens_hsa042100.48990975
118Insulin signaling pathway_Homo sapiens_hsa049100.48031565
119Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.47927656
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.46634346
121Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.46613320
122Cyanoamino acid metabolism_Homo sapiens_hsa004600.45817577
123Homologous recombination_Homo sapiens_hsa034400.44646899
124Epstein-Barr virus infection_Homo sapiens_hsa051690.43941629
125Herpes simplex infection_Homo sapiens_hsa051680.42281313
126Glycerophospholipid metabolism_Homo sapiens_hsa005640.42089389
127TNF signaling pathway_Homo sapiens_hsa046680.41879679
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.39967092
129Hepatitis B_Homo sapiens_hsa051610.38163201
130Parkinsons disease_Homo sapiens_hsa050120.38122788
131Galactose metabolism_Homo sapiens_hsa000520.37192055
132Propanoate metabolism_Homo sapiens_hsa006400.37114494
133Glutathione metabolism_Homo sapiens_hsa004800.36917684
134VEGF signaling pathway_Homo sapiens_hsa043700.35998757
135Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35470448
136Non-small cell lung cancer_Homo sapiens_hsa052230.34829996
137Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.34267004
138Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.34210352
139Cocaine addiction_Homo sapiens_hsa050300.33003450
140Legionellosis_Homo sapiens_hsa051340.32348016
141Choline metabolism in cancer_Homo sapiens_hsa052310.31990662
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.31753397
143Cysteine and methionine metabolism_Homo sapiens_hsa002700.29158600
144Tyrosine metabolism_Homo sapiens_hsa003500.27088799
145Huntingtons disease_Homo sapiens_hsa050160.21923892

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