CPZ

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the metallocarboxypeptidase family. This enzyme displays carboxypeptidase activity towards substrates with basic C-terminal residues. It is most active at neutral pH and is inhibited by active site-directed inhibitors of metallocarboxypeptidases. Alternative splicing in the coding region results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein heterotrimerization (GO:0070208)9.16653519
2collagen fibril organization (GO:0030199)7.29835922
3bone trabecula formation (GO:0060346)6.99712640
4keratan sulfate catabolic process (GO:0042340)6.04408940
5collagen metabolic process (GO:0032963)6.03360960
6collagen catabolic process (GO:0030574)6.01422929
7multicellular organismal macromolecule metabolic process (GO:0044259)5.67376794
8multicellular organismal catabolic process (GO:0044243)5.53976702
9multicellular organismal metabolic process (GO:0044236)5.36765745
10skin morphogenesis (GO:0043589)5.13973347
11chondrocyte proliferation (GO:0035988)5.12820751
12planar cell polarity pathway involved in neural tube closure (GO:0090179)4.91818251
13negative regulation of chondrocyte differentiation (GO:0032331)4.82518228
14extracellular matrix disassembly (GO:0022617)4.73754625
15cartilage development involved in endochondral bone morphogenesis (GO:0060351)4.66860505
16extracellular fibril organization (GO:0043206)4.61323098
17regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.61038906
18paraxial mesoderm development (GO:0048339)4.58357981
19endodermal cell differentiation (GO:0035987)4.54429677
20outer ear morphogenesis (GO:0042473)4.24728250
21negative regulation of cartilage development (GO:0061037)4.21025499
22kidney mesenchyme development (GO:0072074)4.07339910
23chondrocyte development (GO:0002063)4.01238463
24regulation of extracellular matrix disassembly (GO:0010715)3.98403628
25G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.96377964
26regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.94965688
27mesenchymal-epithelial cell signaling (GO:0060638)3.91466309
28fibril organization (GO:0097435)3.88109801
29regulation of vascular endothelial growth factor signaling pathway (GO:1900746)3.84037225
30sequestering of extracellular ligand from receptor (GO:0035581)3.83529714
31regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.76468035
32craniofacial suture morphogenesis (GO:0097094)3.74597323
33axon extension involved in axon guidance (GO:0048846)3.71599478
34neuron projection extension involved in neuron projection guidance (GO:1902284)3.71599478
35protein retention in ER lumen (GO:0006621)3.68008391
36establishment of apical/basal cell polarity (GO:0035089)3.64669898
37extracellular matrix assembly (GO:0085029)3.64402172
38maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.62765367
39tooth mineralization (GO:0034505)3.62631222
40pattern specification involved in kidney development (GO:0061004)3.61395633
41endothelial cell morphogenesis (GO:0001886)3.60676827
42embryonic cranial skeleton morphogenesis (GO:0048701)3.59980124
43non-canonical Wnt signaling pathway (GO:0035567)3.59278576
44Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.55761612
45positive regulation of SMAD protein import into nucleus (GO:0060391)3.54725468
46negative regulation of smooth muscle cell migration (GO:0014912)3.53836773
47endocardial cushion development (GO:0003197)3.51858274
48basement membrane organization (GO:0071711)3.50554207
49mesenchyme morphogenesis (GO:0072132)3.49979060
50vascular endothelial growth factor signaling pathway (GO:0038084)3.44502529
51regulation of establishment of planar polarity (GO:0090175)3.42941865
52positive regulation of fatty acid beta-oxidation (GO:0032000)3.42145126
53negative regulation of fatty acid transport (GO:2000192)3.41551429
54cell proliferation involved in metanephros development (GO:0072203)3.39790417
55positive regulation of endothelial cell apoptotic process (GO:2000353)3.38352272
56virion attachment to host cell (GO:0019062)3.37946194
57adhesion of symbiont to host cell (GO:0044650)3.37946194
58embryonic skeletal joint morphogenesis (GO:0060272)3.35795739
59extracellular matrix organization (GO:0030198)3.35431895
60cellular response to vitamin D (GO:0071305)3.34765079
61extracellular structure organization (GO:0043062)3.34335038
62cell proliferation involved in kidney development (GO:0072111)3.30013869
63protein trimerization (GO:0070206)3.28977617
64anatomical structure regression (GO:0060033)3.28730121
65adherens junction assembly (GO:0034333)3.28262927
66endocardial cushion morphogenesis (GO:0003203)3.27298370
67cellular response to vitamin (GO:0071295)3.25798325
68regulation of plasminogen activation (GO:0010755)3.24853563
69positive regulation of epithelial to mesenchymal transition (GO:0010718)3.24282069
70regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.22358089
71glomerular basement membrane development (GO:0032836)3.21527650
72cell-substrate adherens junction assembly (GO:0007045)3.20002208
73focal adhesion assembly (GO:0048041)3.20002208
74replacement ossification (GO:0036075)3.18695091
75endochondral ossification (GO:0001958)3.18695091
76Golgi transport vesicle coating (GO:0048200)3.17331750
77COPI coating of Golgi vesicle (GO:0048205)3.17331750
78type B pancreatic cell proliferation (GO:0044342)3.16375849
79apoptotic cell clearance (GO:0043277)3.16361002
80convergent extension (GO:0060026)3.15045374
81regulation of cartilage development (GO:0061035)3.14715044
82dichotomous subdivision of an epithelial terminal unit (GO:0060600)3.13528627
83digestive tract morphogenesis (GO:0048546)3.13441561
84cellular response to amino acid stimulus (GO:0071230)3.10582983
85negative regulation of catenin import into nucleus (GO:0035414)3.10054249
86negative regulation of embryonic development (GO:0045992)3.09668316
87negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)3.08717916
88adhesion of symbiont to host (GO:0044406)3.08596246
89regulation of chondrocyte differentiation (GO:0032330)3.06001550
90peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.03095709
91cochlea morphogenesis (GO:0090103)3.02186536
92cartilage condensation (GO:0001502)3.02028510
93cell aggregation (GO:0098743)3.02028510
94anterior/posterior axis specification, embryo (GO:0008595)3.01416402
95negative regulation of cell fate specification (GO:0009996)3.01414358
96cranial suture morphogenesis (GO:0060363)3.00417896
97cell migration involved in heart development (GO:0060973)3.00289807
98glycoprotein catabolic process (GO:0006516)2.98150082
99bone morphogenesis (GO:0060349)2.97977505
100positive regulation of extracellular matrix organization (GO:1903055)2.97643859
101phagocytosis, recognition (GO:0006910)2.97032901
102atrioventricular valve morphogenesis (GO:0003181)2.96287567
103protein localization to cell surface (GO:0034394)2.96204247
104hyaluronan catabolic process (GO:0030214)2.95884706
105positive regulation of fatty acid oxidation (GO:0046321)2.95475183
106polarized epithelial cell differentiation (GO:0030859)2.95327072
107cell-substrate junction assembly (GO:0007044)2.94614012
108cell migration involved in sprouting angiogenesis (GO:0002042)2.94385646
109glial cell migration (GO:0008347)2.93723146
110regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.93518915
111positive regulation of glycogen biosynthetic process (GO:0045725)2.91607862
112middle ear morphogenesis (GO:0042474)2.90915673
113regulation of gastrulation (GO:0010470)2.90810891
114ossification (GO:0001503)2.90509623
115trabecula formation (GO:0060343)2.89800237
116cellular response to BMP stimulus (GO:0071773)2.89367125
117response to BMP (GO:0071772)2.89367125
118regulation of SMAD protein import into nucleus (GO:0060390)2.89116718
119blood vessel maturation (GO:0001955)2.88713115
120positive regulation of cartilage development (GO:0061036)2.88061813
121regulation of non-canonical Wnt signaling pathway (GO:2000050)2.87558745
122glomerular visceral epithelial cell development (GO:0072015)2.87172214
123hippo signaling (GO:0035329)2.86501358
124dermatan sulfate biosynthetic process (GO:0030208)2.86333853
125establishment of monopolar cell polarity (GO:0061162)2.85943098
126establishment or maintenance of monopolar cell polarity (GO:0061339)2.85943098
127establishment of planar polarity (GO:0001736)2.85706784
128establishment of tissue polarity (GO:0007164)2.85706784
129branching involved in salivary gland morphogenesis (GO:0060445)2.85580787
130positive regulation of catenin import into nucleus (GO:0035413)2.84713341
131regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.84470137
132metanephric mesenchyme development (GO:0072075)2.84395239
133establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.84150943
134regulation of catenin import into nucleus (GO:0035412)2.83815665
135substrate adhesion-dependent cell spreading (GO:0034446)2.83443589
136positive regulation of osteoblast proliferation (GO:0033690)2.82460186
137dermatan sulfate metabolic process (GO:0030205)2.77403916
138negative regulation of BMP signaling pathway (GO:0030514)2.75816209
139negative regulation of androgen receptor signaling pathway (GO:0060766)2.75609063
140midgut development (GO:0007494)2.73431533
141lung-associated mesenchyme development (GO:0060484)2.70677208
142eyelid development in camera-type eye (GO:0061029)2.70344099
143negative regulation of osteoblast proliferation (GO:0033689)2.70292061

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human7.40043654
2TP63_17297297_ChIP-ChIP_HaCaT_Human7.03860699
3RARG_19884340_ChIP-ChIP_MEFs_Mouse3.43496356
4PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse3.30157746
5TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.14474441
6CLOCK_20551151_ChIP-Seq_293T_Human2.96625964
7TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human2.52995105
8ESR1_22446102_ChIP-Seq_UTERUS_Mouse2.44399091
9POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.42694072
10RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.31131129
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.13647622
12WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.13205754
13* TP53_20018659_ChIP-ChIP_R1E_Mouse2.09937930
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.05908056
15NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.97926911
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.97304568
17WT1_19549856_ChIP-ChIP_CCG9911_Human1.95143752
18RNF2_18974828_ChIP-Seq_MESCs_Mouse1.89585340
19EZH2_18974828_ChIP-Seq_MESCs_Mouse1.89585340
20CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.81208143
21CJUN_26792858_Chip-Seq_BT549_Human1.77839827
22KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.75993426
23KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.75993426
24KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.75993426
25SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.72587273
26CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.70973201
27ESR2_21235772_ChIP-Seq_MCF-7_Human1.69407209
28NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.66246592
29* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.64913243
30ZNF263_19887448_ChIP-Seq_K562_Human1.62221623
31* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.59967793
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.58786472
33PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.56270209
34SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.56165447
35ELK3_25401928_ChIP-Seq_HUVEC_Human1.55715126
36SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.53574933
37* SA1_22415368_ChIP-Seq_MEFs_Mouse1.49102790
38ERG_21242973_ChIP-ChIP_JURKAT_Human1.47115480
39EZH2_27304074_Chip-Seq_ESCs_Mouse1.46972080
40JARID2_20075857_ChIP-Seq_MESCs_Mouse1.46733561
41BRD4_25478319_ChIP-Seq_HGPS_Human1.44521007
42SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.44002161
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.42556016
44ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.40521669
45UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.40454775
46KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35602778
47TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.34694344
48RBPJ_22232070_ChIP-Seq_NCS_Mouse1.34276052
49EP300_21415370_ChIP-Seq_HL-1_Mouse1.34158771
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.32680093
51KDM2B_26808549_Chip-Seq_K562_Human1.32374812
52ISL1_27105846_Chip-Seq_CPCs_Mouse1.28457642
53RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.27912338
54SMC1_22415368_ChIP-Seq_MEFs_Mouse1.24167820
55EGR1_19374776_ChIP-ChIP_THP-1_Human1.24144787
56SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.23448792
57TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23263610
58RACK7_27058665_Chip-Seq_MCF-7_Human1.22686318
59NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.20074023
60FOXO3_23340844_ChIP-Seq_DLD1_Human1.20022878
61STAT6_21828071_ChIP-Seq_BEAS2B_Human1.19427169
62SOX9_24532713_ChIP-Seq_HFSC_Mouse1.19066255
63ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18861000
64* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17838626
65* LXR_22292898_ChIP-Seq_THP-1_Human1.17334001
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16890045
67ZFP281_27345836_Chip-Seq_ESCs_Mouse1.15948403
68TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.15906134
69RING1B_27294783_Chip-Seq_ESCs_Mouse1.15121584
70HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.13875014
71THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.13871255
72SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.13684303
73NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.13359136
74JARID2_20064375_ChIP-Seq_MESCs_Mouse1.12934166
75TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.11072437
76RING1B_27294783_Chip-Seq_NPCs_Mouse1.09315165
77* TP53_23651856_ChIP-Seq_MEFs_Mouse1.08594875
78TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.08029496
79* TET1_21490601_ChIP-Seq_MESCs_Mouse1.07917530
80KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.07663668
81KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.07509570
82EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.07436276
83BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07293771
84TP53_22127205_ChIP-Seq_IMR90_Human1.06454817
85TCF3_18692474_ChIP-Seq_MEFs_Mouse1.05988108
86KDM2B_26808549_Chip-Seq_JURKAT_Human1.04204447
87UBF1/2_26484160_Chip-Seq_HMECs_Human1.03658408
88PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.03652003
89NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03190135
90CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02811115
91SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.02479018
92TP53_18474530_ChIP-ChIP_U2OS_Human1.02212333
93NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.01633416
94WT1_25993318_ChIP-Seq_PODOCYTE_Human1.01584917
95EZH2_27294783_Chip-Seq_ESCs_Mouse1.01133914
96NRF2_20460467_ChIP-Seq_MEFs_Mouse1.00821904
97NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.00821904
98IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00184152
99DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.99794200
100SOX2_18358816_ChIP-ChIP_MESCs_Mouse0.99624766
101MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.99414547
102AR_21909140_ChIP-Seq_LNCAP_Human0.99200587
103PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99187494
104KDM2B_26808549_Chip-Seq_DND41_Human0.98988946
105EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98917647
106ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98768115
107TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.98630981
108CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98132651
109JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.97598699
110TBX20_22328084_ChIP-Seq_HEART_Mouse0.96923214
111TBX20_22080862_ChIP-Seq_HEART_Mouse0.96923214
112SALL4_18804426_ChIP-ChIP_XEN_Mouse0.96599344
113MTF2_20144788_ChIP-Seq_MESCs_Mouse0.95520018
114STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.95376207
115HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.95213883
116ATF3_27146783_Chip-Seq_COLON_Human0.95025457
117P63_26484246_Chip-Seq_KERATINOCYTES_Human0.94300464
118ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.93800169
119JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.93584536
120SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.93457275
121GATA1_22025678_ChIP-Seq_K562_Human0.93384859
122RAD21_21589869_ChIP-Seq_MESCs_Mouse0.93183597
123SMC3_22415368_ChIP-Seq_MEFs_Mouse0.92245158
124* SA1_27219007_Chip-Seq_ERYTHROID_Human0.91980348
125SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91837423
126* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.91093981

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008438_abnormal_cutaneous_collagen7.71935174
2MP0005503_abnormal_tendon_morphology6.77527091
3MP0005275_abnormal_skin_tensile5.90080715
4MP0003705_abnormal_hypodermis_morpholog3.27978796
5MP0002254_reproductive_system_inflammat3.23186399
6MP0004272_abnormal_basement_membrane2.87612337
7MP0005508_abnormal_skeleton_morphology2.76093653
8MP0001958_emphysema2.69135759
9MP0006054_spinal_hemorrhage2.63289673
10MP0003283_abnormal_digestive_organ2.61377746
11MP0001542_abnormal_bone_strength2.49997788
12MP0005257_abnormal_intraocular_pressure2.48868847
13MP0003279_aneurysm2.35799744
14MP0002108_abnormal_muscle_morphology2.17810943
15MP0004134_abnormal_chest_morphology2.14575702
16MP0002060_abnormal_skin_morphology2.12477950
17MP0002896_abnormal_bone_mineralization2.06570186
18MP0009250_abnormal_appendicular_skeleto1.99791694
19MP0005623_abnormal_meninges_morphology1.92808244
20MP0003385_abnormal_body_wall1.87067658
21MP0003941_abnormal_skin_development1.85912591
22MP0010030_abnormal_orbit_morphology1.83184829
23MP0004858_abnormal_nervous_system1.80043471
24MP0000534_abnormal_ureter_morphology1.67560741
25MP0000163_abnormal_cartilage_morphology1.64934524
26MP0001243_abnormal_dermal_layer1.58807542
27MP0002115_abnormal_skeleton_extremities1.56847689
28MP0005390_skeleton_phenotype1.56108372
29MP0003942_abnormal_urinary_system1.50667650
30MP0002282_abnormal_trachea_morphology1.50586158
31MP0009384_cardiac_valve_regurgitation1.47614826
32MP0002932_abnormal_joint_morphology1.45298147
33MP0009053_abnormal_anal_canal1.41625286
34MP0000049_abnormal_middle_ear1.39308682
35MP0000751_myopathy1.38848712
36MP0000733_abnormal_muscle_development1.33459454
37MP0003115_abnormal_respiratory_system1.33413471
38MP0001348_abnormal_lacrimal_gland1.33229409
39MP0000428_abnormal_craniofacial_morphol1.31684325
40MP0003878_abnormal_ear_physiology1.29435937
41MP0005377_hearing/vestibular/ear_phenot1.29435937
42MP0003122_maternal_imprinting1.29378862
43MP0005023_abnormal_wound_healing1.28169919
44MP0002249_abnormal_larynx_morphology1.27657757
45MP0002113_abnormal_skeleton_development1.25722480
46MP0009780_abnormal_chondrocyte_physiolo1.24381492
47MP0000762_abnormal_tongue_morphology1.24214588
48MP0000462_abnormal_digestive_system1.23603761
49MP0002089_abnormal_postnatal_growth/wei1.21965209
50MP0003566_abnormal_cell_adhesion1.21551885
51MP0002295_abnormal_pulmonary_circulatio1.20440579
52MP0002998_abnormal_bone_remodeling1.19591880
53MP0001299_abnormal_eye_distance/1.18654529
54MP0004185_abnormal_adipocyte_glucose1.18216982
55MP0002933_joint_inflammation1.17556148
56MP0002109_abnormal_limb_morphology1.16098909
57MP0010368_abnormal_lymphatic_system1.14906278
58MP0003950_abnormal_plasma_membrane1.13606480
59MP0002116_abnormal_craniofacial_bone1.11374457
60MP0002233_abnormal_nose_morphology1.11148561
61MP0002111_abnormal_tail_morphology1.09172082
62MP0000767_abnormal_smooth_muscle1.07967274
63MP0005367_renal/urinary_system_phenotyp1.07736424
64MP0000516_abnormal_urinary_system1.07736424
65MP0004233_abnormal_muscle_weight1.02774121
66MP0000579_abnormal_nail_morphology1.00229986
67MP0003755_abnormal_palate_morphology0.97293846
68MP0000432_abnormal_head_morphology0.96219002
69MP0003879_abnormal_hair_cell0.94693233
70MP0005248_abnormal_Harderian_gland0.94138092
71MP0003795_abnormal_bone_structure0.93780800
72MP0005076_abnormal_cell_differentiation0.93489284
73MP0005595_abnormal_vascular_smooth0.92688357
74MP0003123_paternal_imprinting0.92161860
75MP0001533_abnormal_skeleton_physiology0.90840971
76MP0003935_abnormal_craniofacial_develop0.88648529
77MP0002697_abnormal_eye_size0.86865503
78MP0002114_abnormal_axial_skeleton0.81252178
79MP0000537_abnormal_urethra_morphology0.80654216
80MP0003119_abnormal_digestive_system0.78615088
81MP0000750_abnormal_muscle_regeneration0.78482537
82MP0003937_abnormal_limbs/digits/tail_de0.72172205
83MP0005197_abnormal_uvea_morphology0.71747739
84MP0000759_abnormal_skeletal_muscle0.70828528
85MP0010771_integument_phenotype0.70784964
86MP0000003_abnormal_adipose_tissue0.70500725
87MP0004197_abnormal_fetal_growth/weight/0.70071542
88MP0002234_abnormal_pharynx_morphology0.68798386
89MP0003091_abnormal_cell_migration0.66738820
90MP0001849_ear_inflammation0.65222604
91MP0002925_abnormal_cardiovascular_devel0.64533700
92MP0000013_abnormal_adipose_tissue0.63677669
93MP0001915_intracranial_hemorrhage0.62674036
94MP0005193_abnormal_anterior_eye0.62572975
95MP0003448_altered_tumor_morphology0.62506755
96MP0009278_abnormal_bone_marrow0.62280352
97MP0001340_abnormal_eyelid_morphology0.62223873
98MP0002837_dystrophic_cardiac_calcinosis0.61209050
99MP0001661_extended_life_span0.60978690
100MP0009840_abnormal_foam_cell0.60814901
101MP0001286_abnormal_eye_development0.60794483
102MP0002092_abnormal_eye_morphology0.60702710
103MP0000467_abnormal_esophagus_morphology0.60628616
104MP0001270_distended_abdomen0.60575976
105MP0010352_gastrointestinal_tract_polyps0.60496040
106MP0001175_abnormal_lung_morphology0.59395123
107MP0000681_abnormal_thyroid_gland0.59029191
108MP0005058_abnormal_lysosome_morphology0.58835988
109MP0005369_muscle_phenotype0.58740845
110MP0005375_adipose_tissue_phenotype0.58614188
111MP0002796_impaired_skin_barrier0.58585949
112MP0001614_abnormal_blood_vessel0.58550423
113MP0002128_abnormal_blood_circulation0.58412405
114MP0002877_abnormal_melanocyte_morpholog0.57327724
115MP0005164_abnormal_response_to0.56364305
116MP0010234_abnormal_vibrissa_follicle0.56240609
117MP0004133_heterotaxia0.56051106
118MP0002133_abnormal_respiratory_system0.55513860
119MP0005388_respiratory_system_phenotype0.55513860
120MP0002168_other_aberrant_phenotype0.55320858
121MP0005171_absent_coat_pigmentation0.54429571
122MP0001881_abnormal_mammary_gland0.53699129
123MP0010386_abnormal_urinary_bladder0.51534346

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)8.23491892
2Premature rupture of membranes (HP:0001788)6.64092001
3Ankle contracture (HP:0006466)5.49286139
4Biconcave vertebral bodies (HP:0004586)4.71261367
5Atrophic scars (HP:0001075)4.64815422
6Follicular hyperkeratosis (HP:0007502)4.64569640
7Neonatal short-limb short stature (HP:0008921)4.62113102
8Vascular tortuosity (HP:0004948)4.51618127
9Soft skin (HP:0000977)4.50951700
10Aortic dissection (HP:0002647)4.34128936
11Shallow orbits (HP:0000586)4.21402408
12Broad metatarsal (HP:0001783)4.05083284
13Abnormality of dentin (HP:0010299)3.95802984
14Type 1 muscle fiber predominance (HP:0003803)3.93323725
15Bladder diverticulum (HP:0000015)3.75908713
16Fragile skin (HP:0001030)3.74710935
17Wormian bones (HP:0002645)3.72712649
18Arterial tortuosity (HP:0005116)3.67900791
19Mitral valve prolapse (HP:0001634)3.67892728
20Epiphyseal dysplasia (HP:0002656)3.61539615
21Peritonitis (HP:0002586)3.44115223
22Slender build (HP:0001533)3.42049188
23Mild short stature (HP:0003502)3.32880931
24Genu recurvatum (HP:0002816)3.29569093
25Osteoarthritis (HP:0002758)3.25171582
26Blue sclerae (HP:0000592)3.14267048
27Cerebral aneurysm (HP:0004944)3.08847943
28Cervical subluxation (HP:0003308)3.06667369
29Hypoplastic ischia (HP:0003175)3.04193181
30Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.95901560
31Hyperextensible skin (HP:0000974)2.91995533
32Increased connective tissue (HP:0009025)2.86937310
33Morphological abnormality of the middle ear (HP:0008609)2.86327868
34Dilatation of the ascending aorta (HP:0005111)2.81107464
35Spinal rigidity (HP:0003306)2.78921292
36Vertebral compression fractures (HP:0002953)2.78892129
37Abnormality of the ischium (HP:0003174)2.66424794
38Increased variability in muscle fiber diameter (HP:0003557)2.58253063
39Platyspondyly (HP:0000926)2.58066664
40Wrist flexion contracture (HP:0001239)2.54590508
41Joint laxity (HP:0001388)2.54110966
42Mildly elevated creatine phosphokinase (HP:0008180)2.52446621
43Vitreoretinal degeneration (HP:0000655)2.51802854
44Premature skin wrinkling (HP:0100678)2.46768749
45Aortic aneurysm (HP:0004942)2.46279611
46Wide anterior fontanel (HP:0000260)2.44703315
47Nonimmune hydrops fetalis (HP:0001790)2.41341537
48Abnormality of the acetabulum (HP:0003170)2.41228301
49Spondylolisthesis (HP:0003302)2.40134188
50Turricephaly (HP:0000262)2.40116219
51Metaphyseal cupping (HP:0003021)2.38667204
52Aortic valve stenosis (HP:0001650)2.37012607
53Overgrowth (HP:0001548)2.37008586
54Bell-shaped thorax (HP:0001591)2.35360459
55Abnormal delivery (HP:0001787)2.34401025
56Breech presentation (HP:0001623)2.32616068
57Aneurysm (HP:0002617)2.28308616
58Short 4th metacarpal (HP:0010044)2.27984833
59Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.27984833
60Hypoventilation (HP:0002791)2.25492813
61Ectopia lentis (HP:0001083)2.24032246
62Hip contracture (HP:0003273)2.21352090
63Delayed cranial suture closure (HP:0000270)2.20764091
64Deviation of the hallux (HP:0010051)2.19081293
65Striae distensae (HP:0001065)2.18538963
66Abnormality of skeletal muscle fiber size (HP:0012084)2.17489913
67Severe Myopia (HP:0011003)2.17058549
68Hallux valgus (HP:0001822)2.16567424
69Cupped ribs (HP:0000887)2.12286907
70Redundant skin (HP:0001582)2.12146135
71Natal tooth (HP:0000695)2.10677848
72Bowel diverticulosis (HP:0005222)2.09744418
73Broad ribs (HP:0000885)2.07708675
74Mesomelia (HP:0003027)2.07590601
75Femoral bowing (HP:0002980)2.07045962
76Abnormality of the 2nd finger (HP:0004100)2.06286395
77Small epiphyses (HP:0010585)2.05832597
78Absent frontal sinuses (HP:0002688)2.05817791
79Elbow flexion contracture (HP:0002987)2.04203511
80Abnormality of the parietal bone (HP:0002696)2.02136218
81Alopecia of scalp (HP:0002293)2.01362446
82Tibial bowing (HP:0002982)2.01075426
83Coronal craniosynostosis (HP:0004440)2.00773644
84Mitral regurgitation (HP:0001653)2.00412782
85Coxa vara (HP:0002812)1.97664766
86Infantile muscular hypotonia (HP:0008947)1.95604585
87Venous insufficiency (HP:0005293)1.94555457
88Osteopenia (HP:0000938)1.93921094
89Abnormality of the 4th metacarpal (HP:0010012)1.92292250
90Limited hip movement (HP:0008800)1.92166130
91Asymmetry of the thorax (HP:0001555)1.92128379
92Dislocated radial head (HP:0003083)1.91657095
93Irregular epiphyses (HP:0010582)1.91364721
94Delayed closure of the anterior fontanelle (HP:0001476)1.89697708
95Protruding ear (HP:0000411)1.88877381
96Lymphangioma (HP:0100764)1.88543556
97Camptodactyly of toe (HP:0001836)1.86956689
98Abnormality of the phalanges of the 2nd finger (HP:0009541)1.86207742
99Long toe (HP:0010511)1.86118562
100Joint stiffness (HP:0001387)1.86071727
101Aortic regurgitation (HP:0001659)1.84197803
102Persistence of primary teeth (HP:0006335)1.83979346
103Decreased skull ossification (HP:0004331)1.83905843
104Ulnar bowing (HP:0003031)1.83525251
105Thoracolumbar scoliosis (HP:0002944)1.83045201
106Venous abnormality (HP:0002624)1.82403107
107Renal duplication (HP:0000075)1.80986602
108Abnormality of the radial head (HP:0003995)1.80833736
109Inguinal hernia (HP:0000023)1.80388897
110Calcaneovalgus deformity (HP:0001848)1.80380658
111Disproportionate tall stature (HP:0001519)1.80123027
112Broad long bones (HP:0005622)1.79081912
113Abnormal vertebral ossification (HP:0100569)1.78841539
114Arachnodactyly (HP:0001166)1.78762316
115Osteolytic defects of the hand bones (HP:0009699)1.78536271
116Osteolytic defects of the phalanges of the hand (HP:0009771)1.78536271
117Generalized amyotrophy (HP:0003700)1.78164711
118Lumbar hyperlordosis (HP:0002938)1.77734439
119Thin skin (HP:0000963)1.77040779
120Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.76873392
121Flat cornea (HP:0007720)1.76364247
122Round ear (HP:0100830)1.75406975
123Abnormality of skull ossification (HP:0002703)1.75252740
124Thin ribs (HP:0000883)1.74993204
125Choanal stenosis (HP:0000452)1.71438453
126Deformed tarsal bones (HP:0008119)1.70450458
127Selective tooth agenesis (HP:0001592)1.68207267
128Narrow nasal bridge (HP:0000446)1.67118239
129Limb-girdle muscle weakness (HP:0003325)1.65410290
130Hyperacusis (HP:0010780)1.59357996
131Gingival overgrowth (HP:0000212)1.57373502
132Bowed forearm bones (HP:0003956)1.56789580
133Bowing of the arm (HP:0006488)1.56789580
134Short middle phalanx of the 5th finger (HP:0004220)1.56541071

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR27.95753927
2TRIB35.07302652
3PDGFRA3.71411211
4EPHB23.30174880
5SIK13.25109137
6LATS12.73330345
7PKN22.62433537
8LATS22.41510606
9RIPK12.27682611
10TTN2.04266164
11SMG11.99369134
12ERN11.99050717
13PTK61.94332299
14MET1.68049714
15PAK21.60100521
16EPHA31.54191152
17BMX1.50638507
18PTK21.50147208
19FER1.43533627
20MAP3K101.43052588
21TGFBR21.43043908
22EEF2K1.39151126
23DYRK1B1.37195791
24FGFR11.31692979
25AKT31.31324263
26PDGFRB1.26662213
27PIM21.26373312
28STK31.20575257
29CDK61.20194980
30PAK41.19718158
31ILK1.15684002
32LRRK21.14953716
33KIT1.10146657
34MYLK1.06636549
35GRK51.06625497
36MST1R1.04868740
37EPHA21.02276175
38CLK11.02140801
39ROCK11.02092398
40MOS1.00952802
41TTK0.99172562
42DAPK30.97856357
43MTOR0.97073550
44DMPK0.93955705
45PTK2B0.92329371
46MAPK70.91463492
47STK380.90515451
48NTRK10.89357765
49ROCK20.85662418
50EPHB10.85453776
51CAMK1D0.84793013
52NME20.80179987
53PAK30.79716218
54PRKD30.79202825
55FGFR20.76916254
56ICK0.76417245
57TRPM70.74601410
58ERBB20.72305034
59MAP2K10.70475622
60MAP3K60.69068670
61FGFR40.68481430
62CAMK1G0.67754306
63PRKCI0.65740451
64RPS6KA40.61788165
65MAP3K70.60264181
66GRK10.59780921
67RET0.57979548
68CAMK2G0.54271146
69RPS6KA20.52900693
70DAPK20.52795872
71CHUK0.52132081
72NEK20.50375080
73LMTK20.50246000
74MAP2K20.50127457
75TAOK10.50030885
76RPS6KL10.49606110
77RPS6KC10.49606110
78MARK20.48367351
79MELK0.47086128
80RPS6KA60.46799700
81BRAF0.46114662
82SRC0.45157192
83TGFBR10.44487135
84TYRO30.43455697
85TESK10.42635302
86FGFR30.42203909
87RPS6KB20.40144967
88ARAF0.39832453
89FLT30.39438783
90CDC42BPA0.39415353
91PRKD10.39294570
92KDR0.39096368
93MAP3K20.38602145
94MAPK10.37830540
95INSR0.37437816
96TAOK20.36299131
97CDK120.36081252
98STK40.35266621
99SCYL20.35035454
100ERBB40.34024231
101GSK3A0.33921428
102KSR20.33918491
103DYRK20.33078126
104PRKG20.32820340
105CDK90.31677356
106GRK70.30955753
107STK38L0.30297705
108ADRBK10.29791539
109CDK70.28227860
110ERBB30.27135105
111NEK90.27124684
112LIMK10.27033135
113JAK30.26801576
114MAPKAPK20.26323310
115RPS6KA10.25941331
116AKT10.25675729
117ABL20.25567972
118IGF1R0.24831872
119MAPK40.24503608
120WNK10.23615549
121PRKCH0.23584258
122AKT20.23486161
123MAP3K30.23407402
124CDK11A0.23191834
125PRKD20.23015220
126MAP3K120.22968766
127HIPK20.22953208
128PAK10.21793625
129GRK60.20518486
130MAP3K80.17969746
131PIK3CG0.17663425

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045125.91270726
2Protein digestion and absorption_Homo sapiens_hsa049744.79446448
3Basal cell carcinoma_Homo sapiens_hsa052173.64354321
4Focal adhesion_Homo sapiens_hsa045103.25156999
5Hedgehog signaling pathway_Homo sapiens_hsa043403.15212785
6Hippo signaling pathway_Homo sapiens_hsa043902.49102906
7Glycosaminoglycan degradation_Homo sapiens_hsa005312.33826738
8Amoebiasis_Homo sapiens_hsa051462.28977194
9Proteoglycans in cancer_Homo sapiens_hsa052052.24213477
10Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.20854407
11TGF-beta signaling pathway_Homo sapiens_hsa043502.18326515
12AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049332.12128476
13Bladder cancer_Homo sapiens_hsa052191.94447493
14Other glycan degradation_Homo sapiens_hsa005111.92521246
15PI3K-Akt signaling pathway_Homo sapiens_hsa041511.80239588
16Cyanoamino acid metabolism_Homo sapiens_hsa004601.74555783
17Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.67717600
18Wnt signaling pathway_Homo sapiens_hsa043101.66704216
19Small cell lung cancer_Homo sapiens_hsa052221.63330293
20Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.50626196
21Adherens junction_Homo sapiens_hsa045201.47774987
22Malaria_Homo sapiens_hsa051441.42084891
23MicroRNAs in cancer_Homo sapiens_hsa052061.41577988
24Melanogenesis_Homo sapiens_hsa049161.39661124
25Galactose metabolism_Homo sapiens_hsa000521.39540089
26Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.36446235
27N-Glycan biosynthesis_Homo sapiens_hsa005101.34931421
28Melanoma_Homo sapiens_hsa052181.29357213
29Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.27765773
30Dilated cardiomyopathy_Homo sapiens_hsa054141.26314458
31Chronic myeloid leukemia_Homo sapiens_hsa052201.25665278
32Pathways in cancer_Homo sapiens_hsa052001.24860774
33Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.24508161
34Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23767871
35Prostate cancer_Homo sapiens_hsa052151.15207915
36Notch signaling pathway_Homo sapiens_hsa043301.13360826
37Nitrogen metabolism_Homo sapiens_hsa009101.10951000
38Biosynthesis of amino acids_Homo sapiens_hsa012301.04541944
39Axon guidance_Homo sapiens_hsa043601.01781603
40Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.01250856
41Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.97162937
42Glioma_Homo sapiens_hsa052140.97137099
43Pentose phosphate pathway_Homo sapiens_hsa000300.96222579
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.95344997
45Tight junction_Homo sapiens_hsa045300.94361619
46Lysine degradation_Homo sapiens_hsa003100.93217276
47Regulation of actin cytoskeleton_Homo sapiens_hsa048100.89644152
48HTLV-I infection_Homo sapiens_hsa051660.89202357
49Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.88605747
50Selenocompound metabolism_Homo sapiens_hsa004500.88148695
51Folate biosynthesis_Homo sapiens_hsa007900.85319192
52Insulin resistance_Homo sapiens_hsa049310.84989487
53Estrogen signaling pathway_Homo sapiens_hsa049150.84313675
54Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.83428045
55Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.83195125
56One carbon pool by folate_Homo sapiens_hsa006700.82707455
57Colorectal cancer_Homo sapiens_hsa052100.81903094
58Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79368461
59Central carbon metabolism in cancer_Homo sapiens_hsa052300.78835472
60p53 signaling pathway_Homo sapiens_hsa041150.78285114
61Glutathione metabolism_Homo sapiens_hsa004800.77267802
62Platelet activation_Homo sapiens_hsa046110.77172383
63Toxoplasmosis_Homo sapiens_hsa051450.75240936
64Pancreatic cancer_Homo sapiens_hsa052120.74284023
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.73799766
66Leukocyte transendothelial migration_Homo sapiens_hsa046700.73344666
67Vibrio cholerae infection_Homo sapiens_hsa051100.70840030
68Endometrial cancer_Homo sapiens_hsa052130.69266160
69Longevity regulating pathway - mammal_Homo sapiens_hsa042110.67890036
70Viral myocarditis_Homo sapiens_hsa054160.67267672
71Thyroid hormone synthesis_Homo sapiens_hsa049180.67040528
72Renin-angiotensin system_Homo sapiens_hsa046140.66845366
73Complement and coagulation cascades_Homo sapiens_hsa046100.66118101
74Adipocytokine signaling pathway_Homo sapiens_hsa049200.66000483
75Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65634282
76PPAR signaling pathway_Homo sapiens_hsa033200.63804255
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.63493143
78Rap1 signaling pathway_Homo sapiens_hsa040150.61829904
79AMPK signaling pathway_Homo sapiens_hsa041520.60784358
80Thyroid hormone signaling pathway_Homo sapiens_hsa049190.58675995
81Gap junction_Homo sapiens_hsa045400.57822813
82mTOR signaling pathway_Homo sapiens_hsa041500.57754617
83Renal cell carcinoma_Homo sapiens_hsa052110.57351744
84Prion diseases_Homo sapiens_hsa050200.56658386
85Phagosome_Homo sapiens_hsa041450.50703181
86Sulfur relay system_Homo sapiens_hsa041220.50491676
87Dorso-ventral axis formation_Homo sapiens_hsa043200.49431815
88Sphingolipid metabolism_Homo sapiens_hsa006000.47394456
89cGMP-PKG signaling pathway_Homo sapiens_hsa040220.46447836
90Carbon metabolism_Homo sapiens_hsa012000.46081388
91Vitamin B6 metabolism_Homo sapiens_hsa007500.45829605
92Lysosome_Homo sapiens_hsa041420.45330259
93Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.44989565
94TNF signaling pathway_Homo sapiens_hsa046680.43993118
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.43880644
96Neurotrophin signaling pathway_Homo sapiens_hsa047220.42080177
97Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41753925
98Phenylalanine metabolism_Homo sapiens_hsa003600.41182906
99FoxO signaling pathway_Homo sapiens_hsa040680.40981744
100Prolactin signaling pathway_Homo sapiens_hsa049170.38845136
101Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37458484
102Hepatitis B_Homo sapiens_hsa051610.37271872
103Insulin signaling pathway_Homo sapiens_hsa049100.36483880
104Thyroid cancer_Homo sapiens_hsa052160.36315724
105Vascular smooth muscle contraction_Homo sapiens_hsa042700.35574970
106Shigellosis_Homo sapiens_hsa051310.35015759
107Phospholipase D signaling pathway_Homo sapiens_hsa040720.34066102
108GnRH signaling pathway_Homo sapiens_hsa049120.32910988
109Cell cycle_Homo sapiens_hsa041100.32266225
110Endocytosis_Homo sapiens_hsa041440.31560495
111Apoptosis_Homo sapiens_hsa042100.31430842
112Non-small cell lung cancer_Homo sapiens_hsa052230.31388869
113Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.30786833
114Ras signaling pathway_Homo sapiens_hsa040140.28628535
115VEGF signaling pathway_Homo sapiens_hsa043700.27731083
116Bile secretion_Homo sapiens_hsa049760.27421261
117Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.26559466
118Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.24872051
119Viral carcinogenesis_Homo sapiens_hsa052030.24233637
120Acute myeloid leukemia_Homo sapiens_hsa052210.23813600
121Ovarian steroidogenesis_Homo sapiens_hsa049130.23326520
122Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.21237807
123Choline metabolism in cancer_Homo sapiens_hsa052310.20226422
124Cocaine addiction_Homo sapiens_hsa050300.20170075
125Glucagon signaling pathway_Homo sapiens_hsa049220.19777195
126MAPK signaling pathway_Homo sapiens_hsa040100.19497258
127ErbB signaling pathway_Homo sapiens_hsa040120.19046004

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