CR1L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protoporphyrinogen IX metabolic process (GO:0046501)9.61846098
2erythrocyte maturation (GO:0043249)8.92196327
3protoporphyrinogen IX biosynthetic process (GO:0006782)7.26954559
4porphyrin-containing compound biosynthetic process (GO:0006779)6.26835811
5hemoglobin metabolic process (GO:0020027)5.90876043
6antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.77105847
7tetrapyrrole biosynthetic process (GO:0033014)5.65092249
8erythrocyte development (GO:0048821)5.63488993
9porphyrin-containing compound metabolic process (GO:0006778)5.48782967
10heme biosynthetic process (GO:0006783)5.34446774
11regulation of response to osmotic stress (GO:0047484)4.71651732
12antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.65661372
13antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.65661372
14heme metabolic process (GO:0042168)4.61096919
15DNA replication checkpoint (GO:0000076)4.55526656
16antigen processing and presentation of endogenous antigen (GO:0019883)4.35789398
17positive regulation of gamma-delta T cell activation (GO:0046645)4.23802604
18myeloid cell development (GO:0061515)4.15840986
19negative regulation of erythrocyte differentiation (GO:0045647)3.94991115
20regulation of B cell receptor signaling pathway (GO:0050855)3.90138434
21neutrophil activation involved in immune response (GO:0002283)3.82663378
22meiotic chromosome segregation (GO:0045132)3.77244572
23positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.68544427
24nuclear pore complex assembly (GO:0051292)3.68541800
25response to methylmercury (GO:0051597)3.55606929
26tetrapyrrole metabolic process (GO:0033013)3.53885293
27granulocyte differentiation (GO:0030851)3.53700116
28signal peptide processing (GO:0006465)3.49285058
29iron ion import (GO:0097286)3.40082587
30organelle membrane fusion (GO:0090174)3.39521390
31autophagic vacuole fusion (GO:0000046)3.33216975
32megakaryocyte development (GO:0035855)3.27071063
33DNA methylation involved in gamete generation (GO:0043046)3.26840576
34nuclear pore organization (GO:0006999)3.25867309
35regulation of B cell differentiation (GO:0045577)3.25178198
36positive regulation of B cell differentiation (GO:0045579)3.18902306
37regulation of RNA export from nucleus (GO:0046831)3.18625479
38definitive hemopoiesis (GO:0060216)3.06884625
39protein K11-linked deubiquitination (GO:0035871)3.05209297
40positive regulation of granulocyte differentiation (GO:0030854)3.03002275
41leukocyte aggregation (GO:0070486)3.02766568
42ribosomal small subunit assembly (GO:0000028)3.02420145
43regulation of erythrocyte differentiation (GO:0045646)3.01330221
44neutrophil activation (GO:0042119)2.99738280
45positive regulation of T cell mediated cytotoxicity (GO:0001916)2.98455097
46response to interferon-beta (GO:0035456)2.97537603
47mitotic G2/M transition checkpoint (GO:0044818)2.95992256
48positive regulation of interferon-alpha production (GO:0032727)2.94068237
49regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.93828721
50regulation of interferon-beta biosynthetic process (GO:0045357)2.93190771
51regulation of gamma-delta T cell activation (GO:0046643)2.90919868
52regulation of gamma-delta T cell differentiation (GO:0045586)2.90397205
53myeloid dendritic cell activation (GO:0001773)2.89303679
54cellular response to zinc ion (GO:0071294)2.87816457
55cellular extravasation (GO:0045123)2.87177559
56negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.86986482
57positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.86481727
58antigen processing and presentation via MHC class Ib (GO:0002475)2.86024973
59response to type I interferon (GO:0034340)2.84572183
60immunoglobulin mediated immune response (GO:0016064)2.84010143
61response to insecticide (GO:0017085)2.83639031
62cellular response to type I interferon (GO:0071357)2.83248583
63type I interferon signaling pathway (GO:0060337)2.83248583
64mast cell activation (GO:0045576)2.80294177
65regulation of interferon-alpha production (GO:0032647)2.79088846
66regulation of meiosis I (GO:0060631)2.78849075
67mitotic sister chromatid segregation (GO:0000070)2.78617670
68pore complex assembly (GO:0046931)2.77814842
69response to interferon-alpha (GO:0035455)2.77364794
70terpenoid biosynthetic process (GO:0016114)2.76308582
71regulation of histone H3-K9 methylation (GO:0051570)2.75919873
72platelet formation (GO:0030220)2.75551485
73regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.75531777
74DNA replication initiation (GO:0006270)2.75202856
75pigment biosynthetic process (GO:0046148)2.74898272
76positive regulation of erythrocyte differentiation (GO:0045648)2.73982762
77negative regulation of mast cell activation (GO:0033004)2.73832349
78regulation of platelet aggregation (GO:0090330)2.73820629
79modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.73114460
80positive regulation by organism of defense response of other organism involved in symbiotic interact2.73114460
81modulation by symbiont of host immune response (GO:0052553)2.73114460
82positive regulation by symbiont of host defense response (GO:0052509)2.73114460
83modulation by symbiont of host defense response (GO:0052031)2.73114460
84modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.73114460
85mature B cell differentiation involved in immune response (GO:0002313)2.72309152
86positive regulation of antigen processing and presentation (GO:0002579)2.72135355
87lymph node development (GO:0048535)2.71495034
88response to peptidoglycan (GO:0032494)2.69886471
89regulation of oxidative phosphorylation (GO:0002082)2.69798514
90mitotic G2 DNA damage checkpoint (GO:0007095)2.68332409
91cellular response to cadmium ion (GO:0071276)2.67977955
92response to protozoan (GO:0001562)2.67718470
93B cell receptor signaling pathway (GO:0050853)2.67479390
94mature B cell differentiation (GO:0002335)2.67054002
95T cell migration (GO:0072678)2.67048899
96regulation of interleukin-12 biosynthetic process (GO:0045075)2.66535572
97protein-cofactor linkage (GO:0018065)2.66313293
98mitotic nuclear envelope disassembly (GO:0007077)2.66286939
99synapsis (GO:0007129)2.64788471
100granulocyte activation (GO:0036230)2.64710196
101purine nucleobase biosynthetic process (GO:0009113)2.64403343
102vitamin transmembrane transport (GO:0035461)2.63326469
103germinal center formation (GO:0002467)2.63263926
104leukocyte degranulation (GO:0043299)2.61492836
105sphingosine metabolic process (GO:0006670)2.60245119
106respiratory burst (GO:0045730)2.60230328
107proline biosynthetic process (GO:0006561)2.59447888
108microtubule depolymerization (GO:0007019)2.58219525
109detection of other organism (GO:0098543)2.58204642
110sister chromatid segregation (GO:0000819)2.57960324
111regulation of T cell mediated cytotoxicity (GO:0001914)2.57493849
112proteasome assembly (GO:0043248)2.57452530
113interferon-gamma-mediated signaling pathway (GO:0060333)2.57333003
114membrane disassembly (GO:0030397)2.55402578
115nuclear envelope disassembly (GO:0051081)2.55402578
116regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.55375266
117one-carbon compound transport (GO:0019755)2.54728849
118negative thymic T cell selection (GO:0045060)2.54559022
119regulation of histone H3-K4 methylation (GO:0051569)2.54445248
120regulation of mast cell activation (GO:0033003)2.54397682
121pentose metabolic process (GO:0019321)2.54128206
122cellular response to interferon-beta (GO:0035458)2.53696551
123regulation of protein glycosylation (GO:0060049)2.53198315
124negative T cell selection (GO:0043383)2.52254279
125defense response to protozoan (GO:0042832)2.51773277
126regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.51593608
127erythrocyte differentiation (GO:0030218)2.51337053
128DNA topological change (GO:0006265)2.48255306
129negative regulation of viral entry into host cell (GO:0046597)2.46755327
130negative regulation of nitric oxide biosynthetic process (GO:0045019)2.46754200
131pinocytosis (GO:0006907)2.46700193
132regulation of DNA methylation (GO:0044030)2.46388386
133hepatocyte apoptotic process (GO:0097284)2.46251444
134pigment metabolic process (GO:0042440)2.46102009
1352-deoxyribonucleotide biosynthetic process (GO:0009265)2.45216930
136deoxyribose phosphate biosynthetic process (GO:0046385)2.45216930
137negative regulation of cell cycle G2/M phase transition (GO:1902750)2.45187684
138regulation of hypersensitivity (GO:0002883)2.45053154
139N-terminal protein amino acid acetylation (GO:0006474)2.44794991
140positive regulation of humoral immune response (GO:0002922)2.44681480
141myeloid dendritic cell differentiation (GO:0043011)2.44547147
142Arp2/3 complex-mediated actin nucleation (GO:0034314)2.44320101
143detection of molecule of bacterial origin (GO:0032490)2.44301268
144myeloid cell activation involved in immune response (GO:0002275)2.44300668
145pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.42927074
146peptide catabolic process (GO:0043171)2.42459359
147cellular response to thyroid hormone stimulus (GO:0097067)2.42306203
148regulation of respiratory burst (GO:0060263)2.42019799
149regulation of nucleobase-containing compound transport (GO:0032239)2.41400054
150positive regulation of macrophage differentiation (GO:0045651)2.41135151
151production of molecular mediator involved in inflammatory response (GO:0002532)2.41077279
152response to lead ion (GO:0010288)2.41033833
153necroptotic process (GO:0070266)2.40291020
154DNA unwinding involved in DNA replication (GO:0006268)2.39871484
155regulation of inositol phosphate biosynthetic process (GO:0010919)2.38872772
156negative regulation of phagocytosis (GO:0050765)2.36860469
157negative regulation of protein acetylation (GO:1901984)2.36630046
158regulation of antigen processing and presentation (GO:0002577)2.35798504
159centriole replication (GO:0007099)2.34758251
160detection of external biotic stimulus (GO:0098581)2.34742763
161secretory granule organization (GO:0033363)2.33722641
162dendritic cell chemotaxis (GO:0002407)2.33400886
163positive regulation of alpha-beta T cell proliferation (GO:0046641)2.32558636
164B cell mediated immunity (GO:0019724)2.32455228
165myeloid leukocyte activation (GO:0002274)2.32370114
166deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.32258595
167positive regulation of interferon-beta production (GO:0032728)2.31528418
168regulation of mast cell degranulation (GO:0043304)2.30831076
169regulation of alpha-beta T cell proliferation (GO:0046640)2.30382155
170negative regulation of histone methylation (GO:0031061)2.30171176
171detection of bacterium (GO:0016045)2.29859718
172platelet dense granule organization (GO:0060155)2.29611912
173leukocyte cell-cell adhesion (GO:0007159)2.29529838
174chromosome segregation (GO:0007059)2.28964481
175T cell homeostasis (GO:0043029)2.28671976
176positive regulation of megakaryocyte differentiation (GO:0045654)2.28634024
177glycine transport (GO:0015816)2.28270799
178macrophage activation involved in immune response (GO:0002281)2.27834557
179T-helper 1 type immune response (GO:0042088)2.27509122
180dendritic cell migration (GO:0036336)2.27286982
181JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.27059843
182lipopolysaccharide-mediated signaling pathway (GO:0031663)2.26762196
183interferon-gamma production (GO:0032609)2.26573373
184DNA synthesis involved in DNA repair (GO:0000731)2.26514059
185DNA strand elongation involved in DNA replication (GO:0006271)2.26356985
186positive regulation of natural killer cell differentiation (GO:0032825)2.26016362
187CENP-A containing nucleosome assembly (GO:0034080)2.25889528
188negative regulation of viral genome replication (GO:0045071)2.25631681
189glycosphingolipid catabolic process (GO:0046479)2.24269008
190oxygen transport (GO:0015671)13.9699820
191gas transport (GO:0015669)12.3001428

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.10699444
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.68084754
3* GATA1_19941826_ChIP-Seq_K562_Human4.57475027
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.18249977
5IRF8_21731497_ChIP-ChIP_J774_Mouse3.97386173
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.46139632
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.42982789
8FOXM1_23109430_ChIP-Seq_U2OS_Human3.34291901
9SCL_19346495_ChIP-Seq_HPC-7_Human3.29961993
10* GATA2_19941826_ChIP-Seq_K562_Human3.21207185
11MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.17566077
12IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.15639727
13BP1_19119308_ChIP-ChIP_Hs578T_Human3.08891338
14E2F4_17652178_ChIP-ChIP_JURKAT_Human3.07905446
15IRF8_27001747_Chip-Seq_BMDM_Mouse2.88811873
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.83756453
17SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.73093075
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.63351467
19NCOR1_26117541_ChIP-Seq_K562_Human2.61748615
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.56718468
21GATA1_22025678_ChIP-Seq_K562_Human2.55980330
22NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.48270951
23STAT4_19710469_ChIP-ChIP_TH1__Mouse2.42235566
24* MYB_21317192_ChIP-Seq_ERMYB_Mouse2.42092681
25KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.37906472
26SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.28669029
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.26559990
28* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.25779796
29FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.25300716
30EGR1_23403033_ChIP-Seq_LIVER_Mouse2.19708788
31EST1_17652178_ChIP-ChIP_JURKAT_Human2.13133945
32RUNX_20019798_ChIP-Seq_JUKART_Human2.11150772
33SPI1_23547873_ChIP-Seq_NB4_Human2.08637231
34GATA2_21666600_ChIP-Seq_HMVEC_Human2.01494841
35FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.98972772
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.97195110
37MYB_26560356_Chip-Seq_TH2_Human1.96109002
38LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.94076650
39Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.93184419
40NOTCH1_21737748_ChIP-Seq_TLL_Human1.90471659
41ELF1_17652178_ChIP-ChIP_JURKAT_Human1.85099678
42* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.84341847
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.83527463
44SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.79536406
45MYB_26560356_Chip-Seq_TH1_Human1.74947113
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.65815767
47THAP11_20581084_ChIP-Seq_MESCs_Mouse1.64539841
48MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.64529092
49GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.62117008
50KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse1.60936883
51ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.60422603
52SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.57579505
53BRD4_27068464_Chip-Seq_AML-cells_Mouse1.56681604
54ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.56363468
55TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.54935351
56HOXB4_20404135_ChIP-ChIP_EML_Mouse1.53965859
57HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53155226
58CREB1_15753290_ChIP-ChIP_HEK293T_Human1.52914940
59RUNX1_22412390_ChIP-Seq_EML_Mouse1.49348411
60ETS1_20019798_ChIP-Seq_JURKAT_Human1.48058167
61E2F7_22180533_ChIP-Seq_HELA_Human1.46300971
62MAF_26560356_Chip-Seq_TH1_Human1.44512465
63ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44196395
64STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.43708599
65FOXP3_21729870_ChIP-Seq_TREG_Human1.43566996
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43285642
67SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.39734933
68GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.39315092
69* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.37005000
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.35697306
71MYC_18358816_ChIP-ChIP_MESCs_Mouse1.35085285
72VDR_24763502_ChIP-Seq_THP-1_Human1.34669701
73* PU_27001747_Chip-Seq_BMDM_Mouse1.32695455
74CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.32061459
75DCP1A_22483619_ChIP-Seq_HELA_Human1.31239798
76PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.30294226
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29399956
78MYC_18555785_ChIP-Seq_MESCs_Mouse1.28932345
79RXR_22158963_ChIP-Seq_LIVER_Mouse1.27403319
80MYC_19030024_ChIP-ChIP_MESCs_Mouse1.26976354
81SMAD_19615063_ChIP-ChIP_OVARY_Human1.23601591
82E2F1_21310950_ChIP-Seq_MCF-7_Human1.22974555
83GATA3_26560356_Chip-Seq_TH2_Human1.19994952
84* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18917813
85PPARA_22158963_ChIP-Seq_LIVER_Mouse1.17978963
86GATA3_27048872_Chip-Seq_THYMUS_Human1.16663630
87JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.15786899
88HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.15313959
89GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14527159
90PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12712116
91CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.11634090
92CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.10257539
93NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.10049856
94SRF_21415370_ChIP-Seq_HL-1_Mouse1.09783312
95ELK1_19687146_ChIP-ChIP_HELA_Human1.09711567
96LXR_22158963_ChIP-Seq_LIVER_Mouse1.08647267
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.07289857
98PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07232105
99SPI1_23127762_ChIP-Seq_K562_Human1.06539167
100CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.06331160
101E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.06218373
102KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.05985313
103KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.05985313
104KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.05985313
105* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.05678911
106FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.04552649
107TFEB_21752829_ChIP-Seq_HELA_Human1.03976138
108SALL4_22934838_ChIP-ChIP_CD34+_Human1.03879018
109CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.03552663
110NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02776907
111CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01932766
112PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.01920094
113CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.01911923
114POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.98927843
115E2F1_18555785_ChIP-Seq_MESCs_Mouse0.96986478
116CIITA_25753668_ChIP-Seq_RAJI_Human0.96674381
117UTX_26944678_Chip-Seq_JUKART_Human0.96445684
118EGR1_19374776_ChIP-ChIP_THP-1_Human0.95750804
119CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95528332
120MYC_19079543_ChIP-ChIP_MESCs_Mouse0.95374925
121PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.94327716
122VDR_21846776_ChIP-Seq_THP-1_Human0.93420636
123CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.92801825
124RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.92735049
125SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.91893468
126CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.91822741
127SOX2_20726797_ChIP-Seq_SW620_Human0.90874742
128XRN2_22483619_ChIP-Seq_HELA_Human0.89867305
129GATA1_19941827_ChIP-Seq_MEL_Mouse0.89476053
130TP63_17297297_ChIP-ChIP_HaCaT_Human0.89090753
131CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88555224
132FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.86738750
133KDM5A_27292631_Chip-Seq_BREAST_Human0.86289774
134MYC_22102868_ChIP-Seq_BL_Human0.85939351
135BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.85739340
136STAT1_20625510_ChIP-Seq_HELA_Human0.84806182
137TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.84603777
138VDR_24787735_ChIP-Seq_THP-1_Human0.83606141
139* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83383649
140SPI1_20517297_ChIP-Seq_HL60_Human0.82833102
141ETS1_22383799_ChIP-Seq_G1ME_Mouse0.82631445
142MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.82153423
143SALL1_21062744_ChIP-ChIP_HESCs_Human0.81753823
144AR_21909140_ChIP-Seq_LNCAP_Human0.81752120
145STAT3_1855785_ChIP-Seq_MESCs_Mouse0.81617894
146PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.81132718
147SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.80956084
148KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.80840125
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.80159831
150GABP_17652178_ChIP-ChIP_JURKAT_Human0.76460226
151SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.75192927
152SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.75192927
153TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.74850719
154VDR_23849224_ChIP-Seq_CD4+_Human0.74739834
155FLI1_27457419_Chip-Seq_LIVER_Mouse0.74739792

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.75925011
2MP0005083_abnormal_biliary_tract3.38241140
3MP0008995_early_reproductive_senescence2.92089190
4MP0005671_abnormal_response_to2.90710101
5MP0009785_altered_susceptibility_to2.81290075
6MP0003724_increased_susceptibility_to2.78064882
7MP0000685_abnormal_immune_system2.74551659
8MP0003111_abnormal_nucleus_morphology2.51503122
9MP0002148_abnormal_hypersensitivity_rea2.50463155
10MP0005171_absent_coat_pigmentation2.47555286
11MP0008260_abnormal_autophagy2.42640651
12MP0002837_dystrophic_cardiac_calcinosis2.40772564
13MP0001800_abnormal_humoral_immune2.40326969
14MP0005025_abnormal_response_to2.38765660
15MP0003878_abnormal_ear_physiology2.33478941
16MP0005377_hearing/vestibular/ear_phenot2.33478941
17MP0005387_immune_system_phenotype2.32477178
18MP0001790_abnormal_immune_system2.32477178
19MP0003436_decreased_susceptibility_to2.30138025
20MP0002419_abnormal_innate_immunity2.29597437
21MP0002452_abnormal_antigen_presenting2.25649320
22MP0005000_abnormal_immune_tolerance2.21618965
23* MP0004957_abnormal_blastocyst_morpholog2.12911789
24MP0002723_abnormal_immune_serum2.10755950
25MP0002420_abnormal_adaptive_immunity2.06129881
26MP0001819_abnormal_immune_cell2.05080721
27MP0002166_altered_tumor_susceptibility1.97312182
28MP0005379_endocrine/exocrine_gland_phen1.88989498
29MP0002396_abnormal_hematopoietic_system1.87837090
30MP0003763_abnormal_thymus_physiology1.86867113
31MP0005464_abnormal_platelet_physiology1.86169719
32MP0008057_abnormal_DNA_replication1.84510769
33MP0010094_abnormal_chromosome_stability1.83398066
34MP0010155_abnormal_intestine_physiology1.77583974
35MP0006054_spinal_hemorrhage1.76671194
36MP0001853_heart_inflammation1.76559394
37MP0003786_premature_aging1.76240365
38MP0003890_abnormal_embryonic-extraembry1.74614620
39MP0003136_yellow_coat_color1.74339575
40MP0005451_abnormal_body_composition1.69669384
41MP0001873_stomach_inflammation1.69094296
42MP0002398_abnormal_bone_marrow1.65083529
43MP0006082_CNS_inflammation1.63781635
44* MP0001845_abnormal_inflammatory_respons1.62796104
45MP0003300_gastrointestinal_ulcer1.62760042
46MP0002006_tumorigenesis1.62268395
47* MP0000716_abnormal_immune_system1.60484173
48MP0001879_abnormal_lymphatic_vessel1.60185368
49MP0002132_abnormal_respiratory_system1.60175549
50MP0002405_respiratory_system_inflammati1.59833726
51MP0008058_abnormal_DNA_repair1.55236518
52MP0003045_fibrosis1.53363622
53MP0006036_abnormal_mitochondrial_physio1.51644519
54MP0008469_abnormal_protein_level1.46821999
55MP0010368_abnormal_lymphatic_system1.45663217
56MP0002138_abnormal_hepatobiliary_system1.45047406
57MP0000689_abnormal_spleen_morphology1.43126636
58MP0005058_abnormal_lysosome_morphology1.42906319
59MP0002933_joint_inflammation1.41609554
60MP0001533_abnormal_skeleton_physiology1.40117093
61MP0000465_gastrointestinal_hemorrhage1.39486651
62MP0003191_abnormal_cellular_cholesterol1.39361924
63MP0003077_abnormal_cell_cycle1.38547436
64MP0001545_abnormal_hematopoietic_system1.35995434
65MP0005397_hematopoietic_system_phenotyp1.35995434
66* MP0002429_abnormal_blood_cell1.35853944
67MP0005636_abnormal_mineral_homeostasis1.34260301
68MP0009764_decreased_sensitivity_to1.31908875
69MP0005174_abnormal_tail_pigmentation1.31783242
70* MP0002722_abnormal_immune_system1.30003403
71MP0010307_abnormal_tumor_latency1.29662901
72MP0004947_skin_inflammation1.27350335
73MP0006035_abnormal_mitochondrial_morpho1.27171670
74MP0003828_pulmonary_edema1.25544719
75MP0004808_abnormal_hematopoietic_stem1.24696335
76MP0004147_increased_porphyrin_level1.24228500
77MP0002998_abnormal_bone_remodeling1.21949003
78MP0001661_extended_life_span1.20988303
79MP0003693_abnormal_embryo_hatching1.20001804
80MP0005075_abnormal_melanosome_morpholog1.19498213
81MP0002139_abnormal_hepatobiliary_system1.18072650
82MP0003879_abnormal_hair_cell1.17013075
83MP0009333_abnormal_splenocyte_physiolog1.16426535
84MP0000343_altered_response_to1.12955007
85MP0003718_maternal_effect1.12180307
86MP0009697_abnormal_copulation1.12159512
87MP0008004_abnormal_stomach_pH1.11018745
88MP0000490_abnormal_crypts_of1.10870126
89MP0003646_muscle_fatigue1.10604126
90MP0008775_abnormal_heart_ventricle1.10289099
91MP0002653_abnormal_ependyma_morphology1.09636787
92MP0000372_irregular_coat_pigmentation1.08583261
93MP0003866_abnormal_defecation1.06308025
94MP0000313_abnormal_cell_death1.05083357
95MP0008438_abnormal_cutaneous_collagen1.04404506
96MP0004381_abnormal_hair_follicle1.03420721
97MP0003186_abnormal_redox_activity1.03210977
98MP0003172_abnormal_lysosome_physiology1.02969886
99MP0000858_altered_metastatic_potential1.02459336
100MP0008932_abnormal_embryonic_tissue0.99408436
101MP0009763_increased_sensitivity_to0.99170326
102MP0005408_hypopigmentation0.98080121
103MP0005360_urolithiasis0.97254328
104MP0003303_peritoneal_inflammation0.96290649
105MP0003656_abnormal_erythrocyte_physiolo0.96121061
106MP0005365_abnormal_bile_salt0.94207629
107MP0003279_aneurysm0.92249701
108MP0009765_abnormal_xenobiotic_induced0.91724459
109MP0004019_abnormal_vitamin_homeostasis0.91538472
110MP0005310_abnormal_salivary_gland0.91517882
111MP0001730_embryonic_growth_arrest0.91337600
112MP0002332_abnormal_exercise_endurance0.90699057
113MP0000015_abnormal_ear_pigmentation0.89754478
114MP0002019_abnormal_tumor_incidence0.87889970
115MP0003252_abnormal_bile_duct0.87755738
116MP0003806_abnormal_nucleotide_metabolis0.87601351
117MP0003448_altered_tumor_morphology0.87412677
118MP0000767_abnormal_smooth_muscle0.87324947
119MP0000249_abnormal_blood_vessel0.86288032
120MP0002009_preneoplasia0.86072512
121MP0000703_abnormal_thymus_morphology0.84331414
122MP0003795_abnormal_bone_structure0.84289146
123MP0005085_abnormal_gallbladder_physiolo0.83485542
124MP0002095_abnormal_skin_pigmentation0.82719728
125MP0009278_abnormal_bone_marrow0.82468476
126MP0005167_abnormal_blood-brain_barrier0.82159750
127MP0002136_abnormal_kidney_physiology0.82154924
128MP0004782_abnormal_surfactant_physiolog0.81786160
129MP0003183_abnormal_peptide_metabolism0.80848705
130MP0000350_abnormal_cell_proliferation0.80761763
131MP0005076_abnormal_cell_differentiation0.80636194
132MP0001915_intracranial_hemorrhage0.80518417
133MP0000749_muscle_degeneration0.80397101
134MP0001697_abnormal_embryo_size0.78791811
135MP0005390_skeleton_phenotype0.77632331
136MP0008877_abnormal_DNA_methylation0.77469418
137MP0002254_reproductive_system_inflammat0.76987854
138MP0009379_abnormal_foot_pigmentation0.76903980
139MP0004145_abnormal_muscle_electrophysio0.76778406
140MP0004510_myositis0.76230705
141MP0000609_abnormal_liver_physiology0.75978333
142MP0001929_abnormal_gametogenesis0.75821404
143* MP0002086_abnormal_extraembryonic_tissu0.75193850
144MP0001666_abnormal_nutrient_absorption0.74477888
145MP0005380_embryogenesis_phenotype0.73947684
146MP0001672_abnormal_embryogenesis/_devel0.73947684
147MP0003566_abnormal_cell_adhesion0.73821352
148MP0005647_abnormal_sex_gland0.72907293
149MP0009643_abnormal_urine_homeostasis0.72659617
150MP0003221_abnormal_cardiomyocyte_apopto0.70789982
151MP0005645_abnormal_hypothalamus_physiol0.70425129
152MP0001764_abnormal_homeostasis0.70374096
153MP0002210_abnormal_sex_determination0.70263884
154MP0000358_abnormal_cell_content/0.69406229
155* MP0002080_prenatal_lethality0.68772553
156MP0003984_embryonic_growth_retardation0.66633649
157MP0008007_abnormal_cellular_replicative0.65213142

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hemoglobin (HP:0011902)8.96336562
2Poikilocytosis (HP:0004447)8.07743519
3Acanthocytosis (HP:0001927)6.23288580
4Reticulocytosis (HP:0001923)5.76775017
5Hypochromic microcytic anemia (HP:0004840)5.54121978
6Recurrent abscess formation (HP:0002722)5.20951158
7Recurrent bacterial skin infections (HP:0005406)4.87143633
8Polycythemia (HP:0001901)4.71105909
9Abnormal gallbladder physiology (HP:0012438)4.34574093
10Cholecystitis (HP:0001082)4.34574093
11Abnormality of reticulocytes (HP:0004312)4.32003509
12Thrombocytosis (HP:0001894)4.27231236
13Cholelithiasis (HP:0001081)4.05036208
14Chromosomal breakage induced by crosslinking agents (HP:0003221)3.95126393
15Paralysis (HP:0003470)3.80447202
16Ileus (HP:0002595)3.66823045
17Eczematoid dermatitis (HP:0000976)3.65925411
18Abnormal gallbladder morphology (HP:0012437)3.65175931
19Chromsome breakage (HP:0040012)3.60860064
20Myositis (HP:0100614)3.36962866
21Chronic otitis media (HP:0000389)3.36933643
22Hematochezia (HP:0002573)3.31935397
23Pallor (HP:0000980)3.28283440
24Hypochromic anemia (HP:0001931)3.27820676
25Recurrent skin infections (HP:0001581)3.23728981
26Truncus arteriosus (HP:0001660)3.18531071
27Colitis (HP:0002583)3.15859301
28Homocystinuria (HP:0002156)3.10715284
29Abnormality of homocysteine metabolism (HP:0010919)3.10715284
30IgM deficiency (HP:0002850)2.95274757
31Hyperbilirubinemia (HP:0002904)2.94135922
32Recurrent viral infections (HP:0004429)2.91208190
33Inflammation of the large intestine (HP:0002037)2.89634694
34Elevated erythrocyte sedimentation rate (HP:0003565)2.87838450
35Renal cortical cysts (HP:0000803)2.86521869
36Recurrent gram-negative bacterial infections (HP:0005420)2.84876077
37Vacuolated lymphocytes (HP:0001922)2.84854758
38Orchitis (HP:0100796)2.80108660
39Abnormality of macrophages (HP:0004311)2.79528597
40Prolonged bleeding time (HP:0003010)2.79303205
41Recurrent fungal infections (HP:0002841)2.78877096
42Gingival bleeding (HP:0000225)2.76704054
43Optic neuritis (HP:0100653)2.74934430
44Retrobulbar optic neuritis (HP:0100654)2.74934430
45Nausea (HP:0002018)2.69410086
46Autoimmune hemolytic anemia (HP:0001890)2.68961029
47Hypertensive crisis (HP:0100735)2.67093877
48Abnormality of the gallbladder (HP:0005264)2.67048492
49Agammaglobulinemia (HP:0004432)2.66788970
50Spontaneous hematomas (HP:0007420)2.63692578
51Petechiae (HP:0000967)2.63141304
52Gastrointestinal inflammation (HP:0004386)2.61122910
53Hyperthyroidism (HP:0000836)2.59273216
54Abnormal platelet volume (HP:0011876)2.59197039
55Reduced antithrombin III activity (HP:0001976)2.58053479
56Epistaxis (HP:0000421)2.57454576
57Increased neuronal autofluorescent lipopigment (HP:0002074)2.56157015
58Meningitis (HP:0001287)2.55311055
59Vasculitis (HP:0002633)2.55058644
60Aplasia/Hypoplasia of the uvula (HP:0010293)2.51481849
61Hepatocellular carcinoma (HP:0001402)2.50182923
62Autoimmune thrombocytopenia (HP:0001973)2.48214127
63Mediastinal lymphadenopathy (HP:0100721)2.47666070
64Abnormality of T cell number (HP:0011839)2.46885145
65Syringomyelia (HP:0003396)2.38522390
66Spinal cord lesions (HP:0100561)2.38522390
67Cellulitis (HP:0100658)2.37253380
68T lymphocytopenia (HP:0005403)2.34774522
69Birth length less than 3rd percentile (HP:0003561)2.33387720
70Recurrent bronchitis (HP:0002837)2.32300234
71Diaphragmatic weakness (HP:0009113)2.29994259
72Arterial thrombosis (HP:0004420)2.28399811
73Increased mean platelet volume (HP:0011877)2.26846656
74Abnormal delayed hypersensitivity skin test (HP:0002963)2.26594945
75Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.26132765
76Conjugated hyperbilirubinemia (HP:0002908)2.25998758
77Encephalitis (HP:0002383)2.25110398
78Interstitial pulmonary disease (HP:0006530)2.23983759
79Tinnitus (HP:0000360)2.22032427
80Periodontitis (HP:0000704)2.21890340
81Chronic mucocutaneous candidiasis (HP:0002728)2.20650411
82Recurrent cutaneous fungal infections (HP:0011370)2.20650411
83Abnormality of T cells (HP:0002843)2.16882296
84Toxemia of pregnancy (HP:0100603)2.16742078
85Abnormality of the prostate (HP:0008775)2.16627330
86Joint hemorrhage (HP:0005261)2.15322601
87Pulmonary infiltrates (HP:0002113)2.14423025
88Abnormality of the fingertips (HP:0001211)2.12755479
89Gastrointestinal stroma tumor (HP:0100723)2.11308789
90Chronic diarrhea (HP:0002028)2.11181341
91Increased cerebral lipofuscin (HP:0011813)2.10917004
92Myocardial infarction (HP:0001658)2.10450352
93Osteomyelitis (HP:0002754)2.10212651
94Keratoconjunctivitis sicca (HP:0001097)2.10075249
95Abnormality of transition element cation homeostasis (HP:0011030)2.09729815
96Abnormality of chromosome stability (HP:0003220)2.09549264
97Recurrent pneumonia (HP:0006532)2.09228005
98Orthostatic hypotension (HP:0001278)2.08769573
99Abnormality of T cell physiology (HP:0011840)2.07136462
100Lymphopenia (HP:0001888)2.05822749
101Nonimmune hydrops fetalis (HP:0001790)2.04666168
102Obstructive lung disease (HP:0006536)2.03471830
103Chronic obstructive pulmonary disease (HP:0006510)2.03471830
104Abnormal large intestine physiology (HP:0012700)2.01342194
105Purpura (HP:0000979)2.00811141
106Type I transferrin isoform profile (HP:0003642)2.00239108
107Abnormality of the heme biosynthetic pathway (HP:0010472)10.6002798
108Aplasia/Hypoplasia of the earlobes (HP:0009906)1.99410425
109Abnormality of cells of the lymphoid lineage (HP:0012140)1.99029950
110Spondylolisthesis (HP:0003302)1.99029304
111Panhypogammaglobulinemia (HP:0003139)1.98548402
112Gastrointestinal infarctions (HP:0005244)1.97737511
113Neutropenia (HP:0001875)1.96146278
114Pustule (HP:0200039)1.95481414
115Neoplasm of the small intestine (HP:0100833)1.95039180
116Biliary tract neoplasm (HP:0100574)1.94967288
117Reticulocytopenia (HP:0001896)1.94451340
118Abnormal number of erythroid precursors (HP:0012131)1.94168357
119Myelodysplasia (HP:0002863)1.93566886
120Abnormal platelet function (HP:0011869)1.93499047
121Impaired platelet aggregation (HP:0003540)1.93499047
122Microcytic anemia (HP:0001935)1.93353449
123Abnormality of the preputium (HP:0100587)1.91801944
124Keratoconjunctivitis (HP:0001096)1.91495067
125Duplicated collecting system (HP:0000081)1.91215079
126Anorexia (HP:0002039)1.90689272
127Systemic lupus erythematosus (HP:0002725)1.90595620
128Bowel incontinence (HP:0002607)1.89784283
129Recurrent lower respiratory tract infections (HP:0002783)1.88710042
130Leukocytosis (HP:0001974)1.87657469
131Abnormality of iron homeostasis (HP:0011031)1.87652792
132Ankyloglossia (HP:0010296)1.87292054
133IgG deficiency (HP:0004315)1.87137884
134Aplastic anemia (HP:0001915)1.86593365
135Hemoptysis (HP:0002105)1.85848600
136Stomach cancer (HP:0012126)1.84941402
137Generalized aminoaciduria (HP:0002909)1.84518411
138Aortic regurgitation (HP:0001659)1.82914751
139Stillbirth (HP:0003826)1.81688618
140Hypoparathyroidism (HP:0000829)1.81422990
141Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.80811059
142Albinism (HP:0001022)1.78095375
143Increased IgM level (HP:0003496)1.77661490
144Prostate neoplasm (HP:0100787)1.77074654
145Abnormality of the nasal mucosa (HP:0000433)1.77009537
146Acute myeloid leukemia (HP:0004808)1.76985295
147Increased serum ferritin (HP:0003281)1.76917191
148Congenital, generalized hypertrichosis (HP:0004540)1.76735168
149Granulocytopenia (HP:0001913)1.76704113
150Gingivitis (HP:0000230)1.76646501
151Abnormal protein N-linked glycosylation (HP:0012347)1.76318383
152Abnormal protein glycosylation (HP:0012346)1.76318383
153Abnormal glycosylation (HP:0012345)1.76318383
154Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.76318383
155IgA deficiency (HP:0002720)1.76066097
156Seborrheic dermatitis (HP:0001051)1.73911169
157Dysautonomia (HP:0002459)1.70670330
158Amelogenesis imperfecta (HP:0000705)1.69028962
159Abnormality of pyrimidine metabolism (HP:0004353)1.68557266
160Duodenal stenosis (HP:0100867)1.67699342
161Small intestinal stenosis (HP:0012848)1.67699342
162Submucous cleft hard palate (HP:0000176)1.67505442
163Meckel diverticulum (HP:0002245)1.66520588
164Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.66484850
165Abnormality of the renal collecting system (HP:0004742)1.65973729
166Cutaneous photosensitivity (HP:0000992)1.65327802
167Exertional dyspnea (HP:0002875)1.63296881
168Abnormality of sulfur amino acid metabolism (HP:0004339)1.62260953
169Menorrhagia (HP:0000132)1.60058856
170Nephroblastoma (Wilms tumor) (HP:0002667)1.59758752
171Abnormality of cells of the erythroid lineage (HP:0012130)1.57612584
172Conjunctival hamartoma (HP:0100780)1.57462469
173Short middle phalanx of the 5th finger (HP:0004220)1.56699656
174Bone marrow hypocellularity (HP:0005528)1.56049192
175Neoplasm of the rectum (HP:0100743)1.55819764
176Abnormality of the ileum (HP:0001549)1.54212145
177Ventricular fibrillation (HP:0001663)1.53676858

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EIF2AK17.35362767
2TYK23.25800170
3MAP3K142.92357388
4IRAK42.66604654
5TEC2.58249056
6MAP4K12.52940267
7IRAK32.51419360
8KSR22.50089129
9JAK32.48624799
10LATS12.45849035
11KIT2.33194467
12NME22.26568190
13MAP3K22.24575800
14TGFBR22.24491149
15TXK2.23352570
16CDC72.23341356
17TBK12.19038126
18BMX2.07242832
19STK101.99599622
20IKBKE1.99404948
21TIE11.97836592
22JAK11.91082686
23PLK41.87330209
24BTK1.86496272
25IKBKB1.79245874
26STK31.77892151
27TTK1.77669168
28KDR1.77132027
29TGFBR11.72757955
30PRPF4B1.69891366
31GRK61.65879535
32RAF11.62668870
33TAOK21.55654949
34LRRK21.51250059
35TAOK31.50978966
36PIM21.43770247
37FLT31.42756327
38MAP2K31.41418709
39ZAP701.40647226
40CSK1.38868221
41PIK3CG1.37082781
42BUB11.34856382
43NLK1.34696541
44INSRR1.34097063
45NEK91.33570806
46BMPR1B1.33200917
47PTK2B1.30273276
48PLK31.29596257
49BLK1.27179241
50KSR11.26686890
51ITK1.25509298
52ERN11.25201959
53LATS21.25086687
54RPS6KA41.24594676
55BCKDK1.22210452
56CSF1R1.19583107
57MAP3K61.15957196
58FGR1.15938611
59TRPM71.14793625
60PIK3CA1.14643229
61MST41.13607283
62NTRK31.12893454
63MAP3K81.10868564
64LYN1.09329687
65SYK1.07213004
66SIK31.06358774
67BRSK21.04086009
68EEF2K1.03594592
69CHUK1.03163785
70FGFR31.01434097
71GRK50.99795273
72LCK0.98527128
73MAP3K10.95902764
74FGFR40.94842266
75PLK20.93928082
76STK240.92073510
77MYLK0.90511878
78NME10.90491416
79IRAK10.88318191
80EIF2AK20.87827198
81ZAK0.87310913
82NEK10.87072970
83PRKG20.86492353
84PBK0.84685020
85NEK60.83663432
86CDK80.83554668
87VRK10.83421517
88MAP3K30.83015080
89EPHA30.81127682
90NEK20.80309579
91YES10.78666222
92CDK120.76768391
93HCK0.75889892
94PIM10.75281721
95NUAK10.71649213
96PRKCQ0.70780932
97MAP2K10.70109740
98BMPR20.69703939
99PLK10.68847153
100CHEK20.68537227
101STK38L0.67778566
102GRK10.67741832
103CDK90.66820104
104SIK10.63172885
105TAOK10.62385044
106FRK0.61458638
107MATK0.60958420
108EPHB10.60874858
109WEE10.60507449
110CLK10.60344854
111MAP3K50.60133034
112PRKAA20.59806854
113PAK10.58759995
114STK40.58578750
115JAK20.57685971
116RPS6KA50.57114536
117ERBB30.56391277
118CCNB10.55224422
119MAP3K40.54507632
120DYRK30.54192934
121WNK10.53169036
122RIPK40.52704408
123MAPKAPK20.51317931
124EIF2AK30.48020551
125ACVR1B0.47861610
126MAPK150.47106815
127IRAK20.46679516
128IGF1R0.45803863
129GRK70.45463438
130HIPK20.44856396
131MARK30.42617860
132BRSK10.41523828
133MAPK110.40900165
134RET0.40329165
135CHEK10.40303275
136ATR0.39935234
137ADRBK20.39896752
138PRKCD0.39097642
139RPS6KA60.38621627
140MAP2K60.38199702
141MAPK70.37699191
142TNK20.36995757
143ABL10.36984626
144MELK0.36644517
145PINK10.36599434
146RPS6KB20.36322822
147MAPK40.36226838
148PTK60.35851442
149STK160.35709139
150LMTK20.35258729
151PASK0.34596607
152MST1R0.34181601
153MAPKAPK30.33918433
154CDK190.33831041
155ATM0.32584670
156MAP2K40.32232827
157MKNK20.29625109

Predicted pathways (KEGG)

RankGene SetZ-score
1Butirosin and neomycin biosynthesis_Homo sapiens_hsa005244.07135434
2Homologous recombination_Homo sapiens_hsa034402.81327176
3Primary immunodeficiency_Homo sapiens_hsa053402.54756168
4Mismatch repair_Homo sapiens_hsa034302.53089013
5Other glycan degradation_Homo sapiens_hsa005112.35200324
6Intestinal immune network for IgA production_Homo sapiens_hsa046722.31533915
7NF-kappa B signaling pathway_Homo sapiens_hsa040642.28387567
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.24453836
9Leishmaniasis_Homo sapiens_hsa051402.23868229
10Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.23596506
11Staphylococcus aureus infection_Homo sapiens_hsa051502.10170416
12Hematopoietic cell lineage_Homo sapiens_hsa046402.04248463
13Measles_Homo sapiens_hsa051622.03022860
14Cell cycle_Homo sapiens_hsa041102.00378326
15Graft-versus-host disease_Homo sapiens_hsa053321.94971069
16Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.94047432
17Fanconi anemia pathway_Homo sapiens_hsa034601.93199986
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.90464164
19Allograft rejection_Homo sapiens_hsa053301.90285991
20Malaria_Homo sapiens_hsa051441.81984477
21Protein export_Homo sapiens_hsa030601.79420633
22Antigen processing and presentation_Homo sapiens_hsa046121.70023999
23Toll-like receptor signaling pathway_Homo sapiens_hsa046201.69497982
24RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.66835815
25Ribosome_Homo sapiens_hsa030101.64602976
26Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.64203947
27Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.62266905
28Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.57831276
29Osteoclast differentiation_Homo sapiens_hsa043801.56176783
30Legionellosis_Homo sapiens_hsa051341.53444113
31Herpes simplex infection_Homo sapiens_hsa051681.52391242
32Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.49530657
33Caffeine metabolism_Homo sapiens_hsa002321.48289330
34B cell receptor signaling pathway_Homo sapiens_hsa046621.47166279
35Jak-STAT signaling pathway_Homo sapiens_hsa046301.45063689
36Toxoplasmosis_Homo sapiens_hsa051451.38277724
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.37495303
38Pancreatic cancer_Homo sapiens_hsa052121.36092575
39Pentose and glucuronate interconversions_Homo sapiens_hsa000401.33268562
40Glycosaminoglycan degradation_Homo sapiens_hsa005311.31623118
41Pertussis_Homo sapiens_hsa051331.31600441
42Spliceosome_Homo sapiens_hsa030401.29588468
43Complement and coagulation cascades_Homo sapiens_hsa046101.27196353
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.26635399
45Chronic myeloid leukemia_Homo sapiens_hsa052201.25831617
46NOD-like receptor signaling pathway_Homo sapiens_hsa046211.24487612
47Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.21542425
48Non-small cell lung cancer_Homo sapiens_hsa052231.21130536
49TNF signaling pathway_Homo sapiens_hsa046681.20078778
50Influenza A_Homo sapiens_hsa051641.17887304
51RNA transport_Homo sapiens_hsa030131.17628318
52Collecting duct acid secretion_Homo sapiens_hsa049661.16220387
53Lysosome_Homo sapiens_hsa041421.15606797
54Basal transcription factors_Homo sapiens_hsa030221.12429085
55Leukocyte transendothelial migration_Homo sapiens_hsa046701.10114553
56Tuberculosis_Homo sapiens_hsa051521.09696978
57Parkinsons disease_Homo sapiens_hsa050121.08124796
58Nitrogen metabolism_Homo sapiens_hsa009101.07559789
59Asthma_Homo sapiens_hsa053101.06203773
60Apoptosis_Homo sapiens_hsa042101.06092500
61Mineral absorption_Homo sapiens_hsa049781.03698069
62Autoimmune thyroid disease_Homo sapiens_hsa053201.02235026
63VEGF signaling pathway_Homo sapiens_hsa043701.01710963
64Sphingolipid metabolism_Homo sapiens_hsa006001.01453286
65Olfactory transduction_Homo sapiens_hsa047401.01052891
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.99602446
67Oocyte meiosis_Homo sapiens_hsa041140.99359654
68Viral myocarditis_Homo sapiens_hsa054160.96570759
69Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.96436298
70Folate biosynthesis_Homo sapiens_hsa007900.95775947
71Viral carcinogenesis_Homo sapiens_hsa052030.93919637
72Type II diabetes mellitus_Homo sapiens_hsa049300.89804839
73Primary bile acid biosynthesis_Homo sapiens_hsa001200.89518414
74Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88761369
75Oxidative phosphorylation_Homo sapiens_hsa001900.87528727
76Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86563737
77ABC transporters_Homo sapiens_hsa020100.86435307
78HIF-1 signaling pathway_Homo sapiens_hsa040660.85933085
79Vitamin digestion and absorption_Homo sapiens_hsa049770.85003428
80Renal cell carcinoma_Homo sapiens_hsa052110.83506340
81Arachidonic acid metabolism_Homo sapiens_hsa005900.83382579
82Peroxisome_Homo sapiens_hsa041460.82710755
83Thyroid cancer_Homo sapiens_hsa052160.82576746
84Pentose phosphate pathway_Homo sapiens_hsa000300.81225923
85Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.79401973
86Hepatitis B_Homo sapiens_hsa051610.78108829
87Platelet activation_Homo sapiens_hsa046110.76073693
88Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75967605
89Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.75574851
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.75529432
91Histidine metabolism_Homo sapiens_hsa003400.73669032
92Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73264091
93Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.71730140
94Rheumatoid arthritis_Homo sapiens_hsa053230.71720139
95Hepatitis C_Homo sapiens_hsa051600.71318363
96Base excision repair_Homo sapiens_hsa034100.71047496
97N-Glycan biosynthesis_Homo sapiens_hsa005100.70433387
98Dorso-ventral axis formation_Homo sapiens_hsa043200.70380828
99Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.70122979
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69961773
101Systemic lupus erythematosus_Homo sapiens_hsa053220.69846217
102Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.69668476
103Chemokine signaling pathway_Homo sapiens_hsa040620.69290056
104Fatty acid degradation_Homo sapiens_hsa000710.68903026
105Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.68836499
106DNA replication_Homo sapiens_hsa030300.68629018
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.68154996
108Adipocytokine signaling pathway_Homo sapiens_hsa049200.67804265
109Pyruvate metabolism_Homo sapiens_hsa006200.67484255
110Selenocompound metabolism_Homo sapiens_hsa004500.67481389
111Shigellosis_Homo sapiens_hsa051310.64415767
112African trypanosomiasis_Homo sapiens_hsa051430.64107006
113Maturity onset diabetes of the young_Homo sapiens_hsa049500.62946350
114T cell receptor signaling pathway_Homo sapiens_hsa046600.62404027
115Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.61361768
116Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.60181112
117p53 signaling pathway_Homo sapiens_hsa041150.59917913
118Chemical carcinogenesis_Homo sapiens_hsa052040.59541065
119Retinol metabolism_Homo sapiens_hsa008300.59425423
120Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58497615
121One carbon pool by folate_Homo sapiens_hsa006700.57725820
122Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.57647941
123Starch and sucrose metabolism_Homo sapiens_hsa005000.56863887
124Proteasome_Homo sapiens_hsa030500.56751900
125Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.56593065
126Salmonella infection_Homo sapiens_hsa051320.55591119
127Glutathione metabolism_Homo sapiens_hsa004800.55258918
128Sulfur metabolism_Homo sapiens_hsa009200.55095943
129Acute myeloid leukemia_Homo sapiens_hsa052210.54994996
130Endometrial cancer_Homo sapiens_hsa052130.53629127
131Regulation of autophagy_Homo sapiens_hsa041400.53220932
132Small cell lung cancer_Homo sapiens_hsa052220.52888406
133AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52230529
134Fatty acid elongation_Homo sapiens_hsa000620.52091119
135Huntingtons disease_Homo sapiens_hsa050160.51220142
136Non-homologous end-joining_Homo sapiens_hsa034500.51077703
137mRNA surveillance pathway_Homo sapiens_hsa030150.50995403
138Epstein-Barr virus infection_Homo sapiens_hsa051690.50353252
139Type I diabetes mellitus_Homo sapiens_hsa049400.50042984
140ECM-receptor interaction_Homo sapiens_hsa045120.49079098
141Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.48772504
142Tryptophan metabolism_Homo sapiens_hsa003800.48559092
143Pyrimidine metabolism_Homo sapiens_hsa002400.48558412
144Drug metabolism - other enzymes_Homo sapiens_hsa009830.47377600
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47003145
146Steroid biosynthesis_Homo sapiens_hsa001000.46544618
147Nucleotide excision repair_Homo sapiens_hsa034200.46538641
148beta-Alanine metabolism_Homo sapiens_hsa004100.46452460
149Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.45990988
150mTOR signaling pathway_Homo sapiens_hsa041500.45974302
151Phagosome_Homo sapiens_hsa041450.45597528
152RNA degradation_Homo sapiens_hsa030180.44589798
153Carbohydrate digestion and absorption_Homo sapiens_hsa049730.44304816
154FoxO signaling pathway_Homo sapiens_hsa040680.43564734
155Purine metabolism_Homo sapiens_hsa002300.42048532
156Biosynthesis of amino acids_Homo sapiens_hsa012300.41508720
157Inositol phosphate metabolism_Homo sapiens_hsa005620.38472626

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