CRABP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-directed differentiation in epithelial tissue. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1substrate-independent telencephalic tangential migration (GO:0021826)7.10899087
2substrate-independent telencephalic tangential interneuron migration (GO:0021843)7.10899087
3peristalsis (GO:0030432)6.38804755
4neuron projection extension involved in neuron projection guidance (GO:1902284)6.01625322
5axon extension involved in axon guidance (GO:0048846)6.01625322
6behavioral response to nicotine (GO:0035095)5.91969910
7chondrocyte proliferation (GO:0035988)5.74399346
8outer ear morphogenesis (GO:0042473)5.57628911
9cranial nerve structural organization (GO:0021604)5.41940688
10positive regulation of growth hormone secretion (GO:0060124)5.28651176
11mesenchymal-epithelial cell signaling (GO:0060638)5.15570008
12olfactory bulb development (GO:0021772)5.14938835
13facial nerve structural organization (GO:0021612)5.11613960
14eyelid development in camera-type eye (GO:0061029)5.04837019
15planar cell polarity pathway involved in neural tube closure (GO:0090179)4.89060760
16regulation of chromatin binding (GO:0035561)4.88526102
17positive regulation of synaptic transmission, dopaminergic (GO:0032226)4.87897194
18auditory behavior (GO:0031223)4.86649825
19negative regulation of DNA repair (GO:0045738)4.80343935
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.76679952
21regulation of synapse structural plasticity (GO:0051823)4.76649219
22striatum development (GO:0021756)4.73784020
23G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071994.73601650
24regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.71480721
25neuronal ion channel clustering (GO:0045161)4.69191232
26presynaptic membrane organization (GO:0097090)4.68753610
27pyrimidine nucleobase catabolic process (GO:0006208)4.57170536
28neuron fate determination (GO:0048664)4.54982816
29regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)4.54775765
30axonal fasciculation (GO:0007413)4.54670711
31negative regulation of catecholamine secretion (GO:0033604)4.52538509
32sequestering of extracellular ligand from receptor (GO:0035581)4.48402044
33paraxial mesoderm development (GO:0048339)4.41824964
34bone trabecula formation (GO:0060346)4.32213907
35neuron recognition (GO:0008038)4.17815295
36middle ear morphogenesis (GO:0042474)4.12577752
37energy coupled proton transport, down electrochemical gradient (GO:0015985)4.09909840
38ATP synthesis coupled proton transport (GO:0015986)4.09909840
39dosage compensation (GO:0007549)4.09549746
40chaperone-mediated protein transport (GO:0072321)4.09151753
41mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.08141859
42regulation of growth hormone secretion (GO:0060123)4.03884011
43craniofacial suture morphogenesis (GO:0097094)4.02776218
44neurofilament cytoskeleton organization (GO:0060052)4.00948261
45protein neddylation (GO:0045116)3.98737665
46behavioral response to ethanol (GO:0048149)3.97165260
47hippo signaling (GO:0035329)3.96494910
48metanephric mesenchyme development (GO:0072075)3.95128709
49embryonic cranial skeleton morphogenesis (GO:0048701)3.92732875
50negative regulation of fatty acid transport (GO:2000192)3.87249875
51anatomical structure arrangement (GO:0048532)3.84119711
52mechanosensory behavior (GO:0007638)3.81251676
53polarized epithelial cell differentiation (GO:0030859)3.80792180
54collagen fibril organization (GO:0030199)3.77068896
55sequestering of actin monomers (GO:0042989)3.70685323
56kidney mesenchyme development (GO:0072074)3.69496675
57negative regulation of transcription regulatory region DNA binding (GO:2000678)3.67492170
58synaptic transmission, dopaminergic (GO:0001963)3.62128548
59embryonic skeletal joint morphogenesis (GO:0060272)3.59588081
60negative regulation of cytosolic calcium ion concentration (GO:0051481)3.58255897
61negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.57819844
62respiratory electron transport chain (GO:0022904)3.52360603
63protein heterotrimerization (GO:0070208)3.52105438
64negative regulation of chondrocyte differentiation (GO:0032331)3.51730809
65heterochromatin organization (GO:0070828)3.50768845
66cell migration involved in heart development (GO:0060973)3.50067206
67embryonic forelimb morphogenesis (GO:0035115)3.47781622
68phasic smooth muscle contraction (GO:0014821)3.47493698
69electron transport chain (GO:0022900)3.47161731
70establishment of protein localization to mitochondrial membrane (GO:0090151)3.45381363
71negative regulation of catenin import into nucleus (GO:0035414)3.44390932
72negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.43756935
73nucleobase catabolic process (GO:0046113)3.41959610
74body morphogenesis (GO:0010171)3.41893775
75positive regulation of gastrulation (GO:2000543)3.41700273
76neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)3.41012878
77regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)3.40867468
78regulation of dopamine uptake involved in synaptic transmission (GO:0051584)3.40867468
79cell proliferation involved in metanephros development (GO:0072203)3.38258778
80embryonic body morphogenesis (GO:0010172)3.35286593
81forebrain neuron differentiation (GO:0021879)3.32601898
82protein localization to cilium (GO:0061512)3.30018325
83axon extension (GO:0048675)3.29904426
84endocrine hormone secretion (GO:0060986)3.29798225
85regulation of cellular senescence (GO:2000772)3.28679013
86mesenchymal cell proliferation (GO:0010463)3.27938719
87regulation of dopamine secretion (GO:0014059)3.27431222
88behavioral response to cocaine (GO:0048148)3.25912463
89cranial nerve development (GO:0021545)3.25876840
90cranial suture morphogenesis (GO:0060363)3.25839220
91cochlea morphogenesis (GO:0090103)3.23229882
92lateral sprouting from an epithelium (GO:0060601)3.23034049
93negative chemotaxis (GO:0050919)3.19642217
94regulation of transcription regulatory region DNA binding (GO:2000677)3.19603794
95spinal cord association neuron differentiation (GO:0021527)3.16943945
96Wnt signaling pathway, planar cell polarity pathway (GO:0060071)3.15402142
97endodermal cell differentiation (GO:0035987)3.12547541
98negative regulation of axon extension involved in axon guidance (GO:0048843)3.11927162
99positive regulation of epithelial to mesenchymal transition (GO:0010718)3.10228556
100embryonic hindlimb morphogenesis (GO:0035116)3.08414680
101retinal ganglion cell axon guidance (GO:0031290)3.06953885
102forelimb morphogenesis (GO:0035136)3.06222413
103positive regulation of transcription regulatory region DNA binding (GO:2000679)3.05919683
104mesenchyme morphogenesis (GO:0072132)3.05498377
105intraciliary transport (GO:0042073)3.04039856
106cell migration in hindbrain (GO:0021535)3.03597556
107extracellular negative regulation of signal transduction (GO:1900116)3.03170890
108extracellular regulation of signal transduction (GO:1900115)3.03170890
109notochord development (GO:0030903)3.02569719
110regulation of establishment of planar polarity (GO:0090175)3.02083389
111response to auditory stimulus (GO:0010996)3.01720957
112synapse assembly (GO:0007416)3.00718144
113postsynaptic membrane organization (GO:0001941)2.99881958
114hindlimb morphogenesis (GO:0035137)2.99717532
115locomotory exploration behavior (GO:0035641)2.98900192
116response to inactivity (GO:0014854)2.98610412
117response to histamine (GO:0034776)2.98490694
118ganglion development (GO:0061548)2.98461250
119cranial nerve morphogenesis (GO:0021602)2.97686232
120embryonic skeletal system morphogenesis (GO:0048704)2.96946984
121nonmotile primary cilium assembly (GO:0035058)2.95040721
122urogenital system development (GO:0001655)2.94828927
123peptidyl-arginine omega-N-methylation (GO:0035247)2.94634148
124protein localization to synapse (GO:0035418)2.94610334
125proximal/distal pattern formation (GO:0009954)2.90406794
126presynaptic membrane assembly (GO:0097105)2.86753326
127epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.85180852
128cell differentiation in spinal cord (GO:0021515)2.84838964
129regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.84684056
130neuromuscular synaptic transmission (GO:0007274)2.83921506
131establishment of mitochondrion localization (GO:0051654)2.83906070
132convergent extension (GO:0060026)2.83002256
133cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.82632332
134pattern specification involved in kidney development (GO:0061004)2.82612469
135response to nicotine (GO:0035094)2.82415132
136mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.81931766
137nucleosome disassembly (GO:0006337)2.81132572
138protein-DNA complex disassembly (GO:0032986)2.81132572
139transmission of nerve impulse (GO:0019226)2.81034762
140regulation of double-strand break repair (GO:2000779)2.80768183
141positive regulation of fatty acid beta-oxidation (GO:0032000)2.79215507
142positive regulation of smoothened signaling pathway (GO:0045880)2.78837612
143viral transcription (GO:0019083)2.78348716
144negative regulation of cartilage development (GO:0061037)2.78261213
145neuron cell-cell adhesion (GO:0007158)2.77619889
146regulation of cell aging (GO:0090342)2.77302220
147regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)2.77212710
148mesoderm development (GO:0007498)2.76027813
149regulation of cilium movement (GO:0003352)2.75134049
150regulation of heart morphogenesis (GO:2000826)2.74278847
151collagen metabolic process (GO:0032963)2.74099771
152adult walking behavior (GO:0007628)2.74045867
153neuron projection extension (GO:1990138)2.72177164
154regulation of SMAD protein import into nucleus (GO:0060390)2.71809871
155negative regulation of signal transduction by p53 class mediator (GO:1901797)2.71156825
156collagen catabolic process (GO:0030574)2.70315063
157peptidyl-arginine N-methylation (GO:0035246)2.69436742
158peptidyl-arginine methylation (GO:0018216)2.69436742
159regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.69323911
160regulation of epithelial to mesenchymal transition (GO:0010717)2.68637390
161phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.68071606
162negative regulation of neurotransmitter secretion (GO:0046929)2.68056139
163translational termination (GO:0006415)2.66248895
164prepulse inhibition (GO:0060134)2.66132649
165embryonic limb morphogenesis (GO:0030326)2.65612321
166embryonic appendage morphogenesis (GO:0035113)2.65612321
167glial cell migration (GO:0008347)2.65503642
168protein complex biogenesis (GO:0070271)2.64479730
169histone arginine methylation (GO:0034969)2.64295751
170artery development (GO:0060840)2.63796924
171protein polyglutamylation (GO:0018095)2.63789628
172lung-associated mesenchyme development (GO:0060484)2.63107592
173cell proliferation involved in kidney development (GO:0072111)2.62233676
174dermatan sulfate biosynthetic process (GO:0030208)2.60412200
175mesenchyme development (GO:0060485)2.59856755
176skeletal system morphogenesis (GO:0048705)2.59555278
177negative regulation of axon guidance (GO:1902668)2.59249735
178non-canonical Wnt signaling pathway (GO:0035567)2.58974443
179multicellular organismal macromolecule metabolic process (GO:0044259)2.57278147
180negative regulation of circadian rhythm (GO:0042754)2.57188095
181maturation of SSU-rRNA (GO:0030490)2.55997012
182epithelial cilium movement (GO:0003351)2.55452816
183negative regulation of amine transport (GO:0051953)2.54709271
184nerve development (GO:0021675)2.51391041
185ribosomal small subunit assembly (GO:0000028)2.49407138
186central nervous system myelination (GO:0022010)2.47431363
187axon ensheathment in central nervous system (GO:0032291)2.47431363
188regulation of voltage-gated calcium channel activity (GO:1901385)2.47263114
189hydrogen ion transmembrane transport (GO:1902600)2.45880786
190synaptic transmission, cholinergic (GO:0007271)2.45878471
191regulation of neurotransmitter uptake (GO:0051580)2.43931001
192mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.43591292
193NADH dehydrogenase complex assembly (GO:0010257)2.43591292

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse5.92336054
2EZH2_22144423_ChIP-Seq_EOC_Human4.10757434
3TRIM28_21343339_ChIP-Seq_HEK293_Human3.96497703
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.96282005
5NR4A2_19515692_ChIP-ChIP_MN9D_Mouse3.54810790
6TP63_19390658_ChIP-ChIP_HaCaT_Human3.54498815
7RARG_19884340_ChIP-ChIP_MEFs_Mouse2.98168499
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.92996304
9EGR1_19374776_ChIP-ChIP_THP-1_Human2.78366858
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.77053690
11WT1_19549856_ChIP-ChIP_CCG9911_Human2.71195091
12FOXM1_23109430_ChIP-Seq_U2OS_Human2.66495404
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.65081607
14TP53_20018659_ChIP-ChIP_R1E_Mouse2.58153034
15* PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.43023900
16EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.41654391
17ZFP281_18757296_ChIP-ChIP_E14_Mouse2.37103343
18EST1_17652178_ChIP-ChIP_JURKAT_Human2.32162551
19WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse2.23847204
20* EED_16625203_ChIP-ChIP_MESCs_Mouse2.23140655
21TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.21499134
22HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.20129205
23TP63_17297297_ChIP-ChIP_HaCaT_Human2.19398642
24REST_21632747_ChIP-Seq_MESCs_Mouse2.06214102
25RUNX2_24764292_ChIP-Seq_MC3T3_Mouse2.05784486
26* KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.04952731
27MYC_18555785_ChIP-Seq_MESCs_Mouse2.04900100
28ZIC3_20872845_ChIP-ChIP_MESCs_Mouse2.03497946
29SOX2_18555785_ChIP-Seq_MESCs_Mouse2.02750482
30STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02581758
31RNF2_27304074_Chip-Seq_NSC_Mouse2.00351708
32HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.99627857
33* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.97105167
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.95107663
35IRF1_19129219_ChIP-ChIP_H3396_Human1.93207876
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.89048604
37REST_18959480_ChIP-ChIP_MESCs_Mouse1.82278877
38ZFP281_27345836_Chip-Seq_ESCs_Mouse1.80090834
39* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.79614986
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.79546398
41EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.78839578
42EZH2_27304074_Chip-Seq_ESCs_Mouse1.73669299
43CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.72692776
44* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.71491400
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.70777690
46MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.68553792
47* EZH2_18974828_ChIP-Seq_MESCs_Mouse1.64857260
48* RNF2_18974828_ChIP-Seq_MESCs_Mouse1.64857260
49ETS1_20019798_ChIP-Seq_JURKAT_Human1.63387982
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.63191181
51MYC_19079543_ChIP-ChIP_MESCs_Mouse1.61910271
52JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58753299
53* RING1B_27294783_Chip-Seq_NPCs_Mouse1.58243841
54E2F7_22180533_ChIP-Seq_HELA_Human1.56742006
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.55750655
56* SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.54940820
57NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.54534821
58* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.54304251
59GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52154280
60* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.51726951
61BRD4_25478319_ChIP-Seq_HGPS_Human1.51285898
62VDR_22108803_ChIP-Seq_LS180_Human1.50908810
63XRN2_22483619_ChIP-Seq_HELA_Human1.48649419
64CLOCK_20551151_ChIP-Seq_293T_Human1.48414068
65* RING1B_27294783_Chip-Seq_ESCs_Mouse1.47719412
66SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.46199863
67NANOG_16153702_ChIP-ChIP_HESCs_Human1.43765397
68* TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.43497985
69CBX2_27304074_Chip-Seq_ESCs_Mouse1.41721288
70CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.41437609
71FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.40906097
72CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.39777474
73IGF1R_20145208_ChIP-Seq_DFB_Human1.37113351
74NFIB_24661679_ChIP-Seq_LUNG_Mouse1.36434894
75* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.35312973
76TP53_22127205_ChIP-Seq_IMR90_Human1.33901713
77FUS_26573619_Chip-Seq_HEK293_Human1.33730764
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29361980
79MYC_18940864_ChIP-ChIP_HL60_Human1.29305993
80HIF1A_21447827_ChIP-Seq_MCF-7_Human1.28582652
81P300_27058665_Chip-Seq_ZR-75-30cells_Human1.27931766
82THAP11_20581084_ChIP-Seq_MESCs_Mouse1.27352211
83HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.25767227
84RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.25237528
85* ISL1_27105846_Chip-Seq_CPCs_Mouse1.24980901
86CTBP1_25329375_ChIP-Seq_LNCAP_Human1.24438913
87NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.23627234
88SOX2_16153702_ChIP-ChIP_HESCs_Human1.23621937
89FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.22696334
90TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.22177317
91SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.22148210
92ZFP57_27257070_Chip-Seq_ESCs_Mouse1.21486379
93* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.20071547
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.19025912
95SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.18946510
96* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.18821884
97TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.17343789
98ELK3_25401928_ChIP-Seq_HUVEC_Human1.17317045
99TTF2_22483619_ChIP-Seq_HELA_Human1.17223045
100ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17125984
101RNF2_27304074_Chip-Seq_ESCs_Mouse1.16933480
102ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14814139
103* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.14254927
104E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.13791588
105TP53_23651856_ChIP-Seq_MEFs_Mouse1.12952796
106OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.11399533
107SA1_22415368_ChIP-Seq_MEFs_Mouse1.11250015
108SMC1_22415368_ChIP-Seq_MEFs_Mouse1.10696809
109TP53_18474530_ChIP-ChIP_U2OS_Human1.10402418
110SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.08807963
111NELFA_20434984_ChIP-Seq_ESCs_Mouse1.08079572
112EWS_26573619_Chip-Seq_HEK293_Human1.07228919
113UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.05977176
114* SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05866480
115* SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.03523822
116REST_19997604_ChIP-ChIP_NEURONS_Mouse1.03051475
117TCF3_18692474_ChIP-Seq_MEFs_Mouse1.02952586
118ZFX_18555785_ChIP-Seq_MESCs_Mouse1.02479401
119ELK1_19687146_ChIP-ChIP_HELA_Human1.01684512
120KDM2B_26808549_Chip-Seq_SUP-B15_Human1.01000528
121ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00565927
122NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.00547624
123KDM2B_26808549_Chip-Seq_K562_Human1.00358669
124* JARID2_20064375_ChIP-Seq_MESCs_Mouse0.99941726
125ATF3_27146783_Chip-Seq_COLON_Human0.99858369
126E2F1_21310950_ChIP-Seq_MCF-7_Human0.99702219
127DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.99680154
128CJUN_26792858_Chip-Seq_BT549_Human0.99678030
129MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.99481928
130* SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.99191157
131RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.98331083
132STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.98170480
133NANOG_21062744_ChIP-ChIP_HESCs_Human0.97829062
134ELK1_22589737_ChIP-Seq_MCF10A_Human0.97758092
135DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.97716562
136MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.97642829
137ERG_21242973_ChIP-ChIP_JURKAT_Human0.97582063
138KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.97448682
139ZNF274_21170338_ChIP-Seq_K562_Hela0.96997822
140POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.96697332
141GATA1_26923725_Chip-Seq_HPCs_Mouse0.96196969
142KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.96000236
143KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.96000236
144KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.96000236
145SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.95728725
146KDM2B_26808549_Chip-Seq_JURKAT_Human0.95591125
147PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.94275076
148P300_19829295_ChIP-Seq_ESCs_Human0.92518020
149FLI1_27457419_Chip-Seq_LIVER_Mouse0.90613011
150* SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90000889
151IKZF1_21737484_ChIP-ChIP_HCT116_Human0.89574138
152TP53_22573176_ChIP-Seq_HFKS_Human0.89288408
153TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88801586
154POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.88100048
155TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88100048
156POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.87069171
157ETV2_25802403_ChIP-Seq_MESCs_Mouse0.86288800
158* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.85814185
159KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.85084157
160YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.83231917
161TOP2B_26459242_ChIP-Seq_MCF-7_Human0.81382104
162CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.80216316
163MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.80024604
164VDR_23849224_ChIP-Seq_CD4+_Human0.78745850

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002822_catalepsy8.46700627
2MP0008438_abnormal_cutaneous_collagen4.47818183
3MP0005503_abnormal_tendon_morphology4.00805831
4MP0008789_abnormal_olfactory_epithelium3.84188306
5MP0003880_abnormal_central_pattern3.69801932
6MP0001188_hyperpigmentation3.47548516
7MP0005423_abnormal_somatic_nervous3.39764283
8MP0003705_abnormal_hypodermis_morpholog3.27232882
9MP0010030_abnormal_orbit_morphology3.25592764
10MP0001529_abnormal_vocalization3.01254196
11MP0005499_abnormal_olfactory_system3.00538410
12MP0005394_taste/olfaction_phenotype3.00538410
13MP0005623_abnormal_meninges_morphology2.87439068
14MP0003385_abnormal_body_wall2.81045269
15MP0009250_abnormal_appendicular_skeleto2.73424299
16MP0009053_abnormal_anal_canal2.49316489
17MP0005275_abnormal_skin_tensile2.48375120
18MP0000778_abnormal_nervous_system2.42849057
19MP0000049_abnormal_middle_ear2.31066257
20MP0006276_abnormal_autonomic_nervous2.30951281
21MP0003942_abnormal_urinary_system2.16956934
22MP0001293_anophthalmia2.04535242
23MP0000955_abnormal_spinal_cord2.01677779
24MP0002938_white_spotting1.92668146
25MP0000534_abnormal_ureter_morphology1.91602878
26MP0002233_abnormal_nose_morphology1.90518387
27MP0003279_aneurysm1.87934237
28MP0002932_abnormal_joint_morphology1.84820989
29MP0005508_abnormal_skeleton_morphology1.84369445
30MP0002735_abnormal_chemical_nociception1.83429989
31MP0002249_abnormal_larynx_morphology1.82045935
32MP0003755_abnormal_palate_morphology1.81211578
33MP0002184_abnormal_innervation1.81021929
34MP0000428_abnormal_craniofacial_morphol1.78122127
35MP0001299_abnormal_eye_distance/1.71807931
36MP0003121_genomic_imprinting1.70859856
37MP0002638_abnormal_pupillary_reflex1.69392416
38MP0005645_abnormal_hypothalamus_physiol1.67827624
39MP0000733_abnormal_muscle_development1.67825727
40MP0006292_abnormal_olfactory_placode1.65583990
41MP0005187_abnormal_penis_morphology1.63694545
42MP0005386_behavior/neurological_phenoty1.63331340
43MP0004924_abnormal_behavior1.63331340
44MP0003937_abnormal_limbs/digits/tail_de1.62472907
45MP0001984_abnormal_olfaction1.62469496
46MP0002102_abnormal_ear_morphology1.61812616
47MP0004270_analgesia1.61663194
48MP0005646_abnormal_pituitary_gland1.60240604
49MP0003787_abnormal_imprinting1.60235646
50MP0001486_abnormal_startle_reflex1.59479234
51MP0001905_abnormal_dopamine_level1.57722849
52MP0002282_abnormal_trachea_morphology1.57159237
53MP0009379_abnormal_foot_pigmentation1.55836459
54MP0003011_delayed_dark_adaptation1.55236942
55MP0004272_abnormal_basement_membrane1.54951893
56MP0003122_maternal_imprinting1.54205289
57MP0004859_abnormal_synaptic_plasticity1.50842811
58MP0002909_abnormal_adrenal_gland1.49556743
59MP0002272_abnormal_nervous_system1.49423984
60MP0000537_abnormal_urethra_morphology1.44774603
61MP0005257_abnormal_intraocular_pressure1.44032554
62MP0002752_abnormal_somatic_nervous1.42649389
63MP0002116_abnormal_craniofacial_bone1.41645828
64MP0001958_emphysema1.41505964
65MP0005076_abnormal_cell_differentiation1.39421941
66MP0002896_abnormal_bone_mineralization1.37108951
67MP0002177_abnormal_outer_ear1.36053375
68MP0005023_abnormal_wound_healing1.35924015
69MP0002733_abnormal_thermal_nociception1.35508057
70MP0009745_abnormal_behavioral_response1.35412665
71MP0003635_abnormal_synaptic_transmissio1.32471971
72MP0002734_abnormal_mechanical_nocicepti1.31410523
73MP0002557_abnormal_social/conspecific_i1.31132461
74MP0002882_abnormal_neuron_morphology1.30805684
75MP0000432_abnormal_head_morphology1.30366485
76MP0003935_abnormal_craniofacial_develop1.29786706
77MP0000163_abnormal_cartilage_morphology1.27266667
78MP0003123_paternal_imprinting1.26634205
79MP0009046_muscle_twitch1.25945737
80MP0002092_abnormal_eye_morphology1.24898837
81MP0001542_abnormal_bone_strength1.24865444
82MP0002111_abnormal_tail_morphology1.22516418
83MP0008877_abnormal_DNA_methylation1.18748561
84MP0002115_abnormal_skeleton_extremities1.18444372
85MP0003115_abnormal_respiratory_system1.18119255
86MP0002089_abnormal_postnatal_growth/wei1.16532408
87MP0009384_cardiac_valve_regurgitation1.16215540
88MP0001849_ear_inflammation1.14187889
89MP0002063_abnormal_learning/memory/cond1.13900990
90MP0004811_abnormal_neuron_physiology1.12859716
91MP0003091_abnormal_cell_migration1.12789302
92* MP0002109_abnormal_limb_morphology1.12652852
93MP0004142_abnormal_muscle_tone1.12596582
94MP0003283_abnormal_digestive_organ1.11339366
95MP0002064_seizures1.10648042
96MP0002114_abnormal_axial_skeleton1.10296786
97MP0003315_abnormal_perineum_morphology1.09698233
98MP0004233_abnormal_muscle_weight1.09575204
99MP0002108_abnormal_muscle_morphology1.09371319
100MP0008007_abnormal_cellular_replicative1.09120313
101MP0003567_abnormal_fetal_cardiomyocyte1.08980607
102MP0001286_abnormal_eye_development1.08314590
103MP0002653_abnormal_ependyma_morphology1.08291004
104MP0006054_spinal_hemorrhage1.07894985
105MP0002160_abnormal_reproductive_system1.07588542
106MP0002163_abnormal_gland_morphology1.07405803
107MP0002572_abnormal_emotion/affect_behav1.05271341
108MP0000372_irregular_coat_pigmentation1.05112335
109MP0002113_abnormal_skeleton_development1.04299574
110MP0004197_abnormal_fetal_growth/weight/1.04204124
111MP0001968_abnormal_touch/_nociception1.03583260
112MP0000631_abnormal_neuroendocrine_gland1.02759393
113MP0004134_abnormal_chest_morphology1.01777434
114MP0003861_abnormal_nervous_system1.01665299
115MP0001970_abnormal_pain_threshold1.00392558
116MP0002697_abnormal_eye_size1.00065638
117MP0003718_maternal_effect1.00034411
118MP0000762_abnormal_tongue_morphology0.99627680
119MP0002152_abnormal_brain_morphology0.98253519
120MP0000026_abnormal_inner_ear0.97085423
121MP0003890_abnormal_embryonic-extraembry0.96843277
122MP0010352_gastrointestinal_tract_polyps0.96559761
123MP0002060_abnormal_skin_morphology0.95294121
124MP0004885_abnormal_endolymph0.95187512
125MP0005253_abnormal_eye_physiology0.95139057
126MP0005409_darkened_coat_color0.95109937
127MP0003119_abnormal_digestive_system0.94174318
128MP0002085_abnormal_embryonic_tissue0.94042677
129MP0002081_perinatal_lethality0.93712171
130MP0001340_abnormal_eyelid_morphology0.93198800
131MP0002295_abnormal_pulmonary_circulatio0.92149350
132MP0003941_abnormal_skin_development0.91660469
133MP0004133_heterotaxia0.91563271
134MP0005248_abnormal_Harderian_gland0.90995400
135MP0005167_abnormal_blood-brain_barrier0.90617340
136MP0008932_abnormal_embryonic_tissue0.90405870
137MP0001485_abnormal_pinna_reflex0.90031598
138MP0002067_abnormal_sensory_capabilities0.89301586
139MP0001986_abnormal_taste_sensitivity0.88822074
140MP0001243_abnormal_dermal_layer0.88602839
141MP0000516_abnormal_urinary_system0.87671243
142MP0005367_renal/urinary_system_phenotyp0.87671243
143MP0000767_abnormal_smooth_muscle0.87447299
144MP0000566_synostosis0.85810361
145MP0002736_abnormal_nociception_after0.85521493
146MP0002084_abnormal_developmental_patter0.84158396
147MP0003878_abnormal_ear_physiology0.83484069
148MP0005377_hearing/vestibular/ear_phenot0.83484069
149MP0004145_abnormal_muscle_electrophysio0.81141614
150MP0005195_abnormal_posterior_eye0.80864100
151MP0000003_abnormal_adipose_tissue0.80368329
152MP0005197_abnormal_uvea_morphology0.78805366
153MP0009703_decreased_birth_body0.78716092
154MP0000858_altered_metastatic_potential0.78634443
155MP0008058_abnormal_DNA_repair0.76436536
156MP0003938_abnormal_ear_development0.76197308
157MP0004742_abnormal_vestibular_system0.75985008
158MP0002751_abnormal_autonomic_nervous0.74196242
159MP0005391_vision/eye_phenotype0.74150025
160MP0000750_abnormal_muscle_regeneration0.73850122
161MP0000427_abnormal_hair_cycle0.73792734
162MP0008995_early_reproductive_senescence0.69041812
163MP0002066_abnormal_motor_capabilities/c0.68579552
164MP0002069_abnormal_eating/drinking_beha0.68104110
165MP0005084_abnormal_gallbladder_morpholo0.66160651
166MP0002928_abnormal_bile_duct0.64759460
167MP0001324_abnormal_eye_pigmentation0.64714062
168MP0005551_abnormal_eye_electrophysiolog0.61514562

Predicted human phenotypes

RankGene SetZ-score
1Protrusio acetabuli (HP:0003179)6.48714813
2Shallow orbits (HP:0000586)4.94096781
3Premature rupture of membranes (HP:0001788)4.84139279
4Reticulocytopenia (HP:0001896)4.23274048
5Abnormal number of erythroid precursors (HP:0012131)4.12015762
6Coronal craniosynostosis (HP:0004440)4.02703635
7Abnormality of cells of the erythroid lineage (HP:0012130)4.00646823
8Broad metatarsal (HP:0001783)3.87669540
9Ankle contracture (HP:0006466)3.83540399
10Myokymia (HP:0002411)3.78736423
11Wrist flexion contracture (HP:0001239)3.73346483
12Short 4th metacarpal (HP:0010044)3.73219090
13Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.73219090
14Abnormality of dentin (HP:0010299)3.70949323
15Vaginal atresia (HP:0000148)3.63337471
16Genital tract atresia (HP:0001827)3.61921116
17Syringomyelia (HP:0003396)3.51344217
18Spinal cord lesions (HP:0100561)3.51344217
19Medial flaring of the eyebrow (HP:0010747)3.43784991
20Gait imbalance (HP:0002141)3.43365795
21Cerebral aneurysm (HP:0004944)3.38831856
22Cervical subluxation (HP:0003308)3.36612137
23Pelvic girdle muscle weakness (HP:0003749)3.35556511
24Mesomelia (HP:0003027)3.30624115
25Congenital primary aphakia (HP:0007707)3.30528620
26Hepatoblastoma (HP:0002884)3.24945875
27Soft skin (HP:0000977)3.19388192
28Increased hepatocellular lipid droplets (HP:0006565)3.17593868
29Nephrogenic diabetes insipidus (HP:0009806)3.15633065
30Acute lymphatic leukemia (HP:0006721)3.04873695
31Acute necrotizing encephalopathy (HP:0006965)3.03665897
32Cortical dysplasia (HP:0002539)3.00372860
33Abnormality of the parietal bone (HP:0002696)2.95531821
34Vertebral compression fractures (HP:0002953)2.94942460
35Abnormality of the hip-girdle musculature (HP:0001445)2.94336793
36Abnormality of the musculature of the pelvis (HP:0001469)2.94336793
37Mitochondrial inheritance (HP:0001427)2.93068681
38Aortic dissection (HP:0002647)2.92141925
39Deviation of the hallux (HP:0010051)2.87755220
40Renal duplication (HP:0000075)2.85720951
41Bladder diverticulum (HP:0000015)2.82433944
42Hepatocellular necrosis (HP:0001404)2.80837437
43Abnormality of the 4th metacarpal (HP:0010012)2.79759776
44Asymmetry of the thorax (HP:0001555)2.77844903
45Lipid accumulation in hepatocytes (HP:0006561)2.76904887
46Peritonitis (HP:0002586)2.76650357
47Renal Fanconi syndrome (HP:0001994)2.76145112
48Aortic aneurysm (HP:0004942)2.74979986
49Facial cleft (HP:0002006)2.72753142
50Broad toe (HP:0001837)2.71111754
51Abnormal mitochondria in muscle tissue (HP:0008316)2.68681479
52Abnormality of the lower motor neuron (HP:0002366)2.67074595
53Hallux valgus (HP:0001822)2.66236939
54Dilatation of the ascending aorta (HP:0005111)2.65192872
55Wormian bones (HP:0002645)2.62642844
56Blue sclerae (HP:0000592)2.57928190
57Poor coordination (HP:0002370)2.55175603
583-Methylglutaconic aciduria (HP:0003535)2.51391413
59Turricephaly (HP:0000262)2.51234820
60Sparse lateral eyebrow (HP:0005338)2.50400359
61Increased CSF lactate (HP:0002490)2.49434887
62Rib fusion (HP:0000902)2.49322955
63Horseshoe kidney (HP:0000085)2.47732038
64Renal dysplasia (HP:0000110)2.46696918
65Anophthalmia (HP:0000528)2.46312828
66Abnormal pancreas size (HP:0012094)2.45637537
67Growth hormone deficiency (HP:0000824)2.45367830
68Septo-optic dysplasia (HP:0100842)2.44993040
69Trigonocephaly (HP:0000243)2.42304687
70Biconcave vertebral bodies (HP:0004586)2.41023153
71Acute encephalopathy (HP:0006846)2.39540723
72Buphthalmos (HP:0000557)2.38667419
73Ulnar bowing (HP:0003031)2.36579630
74Pancreatic cysts (HP:0001737)2.36008362
75Hepatic necrosis (HP:0002605)2.34568197
76Progressive macrocephaly (HP:0004481)2.33163104
77Hyperglycinemia (HP:0002154)2.32538979
78Optic nerve hypoplasia (HP:0000609)2.31646173
79Adrenal hypoplasia (HP:0000835)2.31484403
80Vascular tortuosity (HP:0004948)2.30710140
81Fragile skin (HP:0001030)2.29046175
82Broad hallux (HP:0010055)2.28422997
83Abnormality of the 2nd finger (HP:0004100)2.28066999
84Renal hypoplasia (HP:0000089)2.27983347
85Abnormality of the phalanges of the hallux (HP:0010057)2.26701258
86Atrophic scars (HP:0001075)2.24567012
87Mitral valve prolapse (HP:0001634)2.23961270
88Wide anterior fontanel (HP:0000260)2.22329782
89Limb-girdle muscle weakness (HP:0003325)2.21797909
90Neonatal short-limb short stature (HP:0008921)2.20377640
91Polyphagia (HP:0002591)2.20351305
92Nonprogressive disorder (HP:0003680)2.20172119
93Torticollis (HP:0000473)2.19567147
94Methylmalonic acidemia (HP:0002912)2.18357611
95Focal dystonia (HP:0004373)2.16500743
96Camptodactyly of toe (HP:0001836)2.15350910
97Abnormality of macular pigmentation (HP:0008002)2.12795401
98Esotropia (HP:0000565)2.12246198
99Pachygyria (HP:0001302)2.11505583
100Increased intramyocellular lipid droplets (HP:0012240)2.11228283
101Colon cancer (HP:0003003)2.10873448
102Microglossia (HP:0000171)2.10421992
103Absent eyebrow (HP:0002223)2.09972530
104Bicornuate uterus (HP:0000813)2.09601734
105Genu recurvatum (HP:0002816)2.09262782
106Stenosis of the external auditory canal (HP:0000402)2.09145938
107Broad long bones (HP:0005622)2.08892919
108Arterial tortuosity (HP:0005116)2.08620173
109Abnormality of the labia minora (HP:0012880)2.08016770
110Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.07672747
111Hypoplasia of the maxilla (HP:0000327)2.06842623
112Intestinal atresia (HP:0011100)2.06440097
113Abnormality of the corticospinal tract (HP:0002492)2.06082019
114Optic nerve coloboma (HP:0000588)2.05480604
115Hypoplasia of the brainstem (HP:0002365)2.03950269
116Aplasia/Hypoplasia of the brainstem (HP:0007362)2.03950269
117Follicular hyperkeratosis (HP:0007502)2.03440005
118Bowel diverticulosis (HP:0005222)2.02870964
119Craniofacial dystonia (HP:0012179)2.02815148
120Bell-shaped thorax (HP:0001591)2.02612685
121Broad foot (HP:0001769)2.02579793
122Delayed cranial suture closure (HP:0000270)2.02200254
123Pancreatic fibrosis (HP:0100732)2.01929824
124Short 5th finger (HP:0009237)2.00653973
125Metaphyseal dysplasia (HP:0100255)2.00594151
126Limb dystonia (HP:0002451)2.00438811
127Increased number of teeth (HP:0011069)2.00260370
128Anomalous pulmonary venous return (HP:0010772)1.99897264
129Elbow flexion contracture (HP:0002987)1.99350926
130Meningocele (HP:0002435)1.98859364
131Agitation (HP:0000713)1.98855236
132Morphological abnormality of the middle ear (HP:0008609)1.96658264
133Palpebral edema (HP:0100540)1.95535320
134Type 1 muscle fiber predominance (HP:0003803)1.94963018
135Methylmalonic aciduria (HP:0012120)1.93982320
136Pallor (HP:0000980)1.92047362
137Broad finger (HP:0001500)1.91767441
138Abnormality of the phalanges of the 2nd finger (HP:0009541)1.91766805
139Broad-based gait (HP:0002136)1.91340562
140Specific learning disability (HP:0001328)1.90448815
141Broad phalanx (HP:0006009)1.90235280
142Nephronophthisis (HP:0000090)1.89742017
143Retinal dysplasia (HP:0007973)1.89058023
144Exertional dyspnea (HP:0002875)1.87164533
145Anosmia (HP:0000458)1.85493884
146Chin dimple (HP:0010751)1.85162946
147Atresia of the external auditory canal (HP:0000413)1.84009687
148Abnormality of the acetabulum (HP:0003170)1.83383764
149Breast aplasia (HP:0100783)1.83289864
150Broad thumb (HP:0011304)1.83109144
151Bifid tongue (HP:0010297)1.82990184
152Disproportionate tall stature (HP:0001519)1.82857645
153Amyotrophic lateral sclerosis (HP:0007354)1.82821572
154Aplasia/Hypoplasia of the sternum (HP:0006714)1.82758636
155Postaxial hand polydactyly (HP:0001162)1.82580010
156Narrow nasal bridge (HP:0000446)1.81539637
157Aplasia/Hypoplasia of the breasts (HP:0010311)1.81084870
158Selective tooth agenesis (HP:0001592)1.81043639
159Midline defect of the nose (HP:0004122)1.80359751
160Duplication of thumb phalanx (HP:0009942)1.80326998
161Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.80045810
162Slender build (HP:0001533)1.80044608
163Abnormality of renal resorption (HP:0011038)1.79701828
164Joint laxity (HP:0001388)1.78831955
165Chorioretinal coloboma (HP:0000567)1.77896720
166Abnormal number of incisors (HP:0011064)1.77477217
167Abnormality of the aortic arch (HP:0012303)1.77385008
168Hypogonadotrophic hypogonadism (HP:0000044)1.77371737
169Abnormality of the renal collecting system (HP:0004742)1.77137482
170Micropenis (HP:0000054)1.76679483
171Short middle phalanx of the 5th finger (HP:0004220)1.76161141
172Ectopic kidney (HP:0000086)1.76142887
173Duplicated collecting system (HP:0000081)1.75987152
174Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.75873406
175Decreased activity of mitochondrial respiratory chain (HP:0008972)1.75873406
176Spinal rigidity (HP:0003306)1.75333608
177Neoplasm of the adrenal cortex (HP:0100641)1.75110892
178Broad phalanges of the hand (HP:0009768)1.74893505
179Dislocated radial head (HP:0003083)1.74001866
180Cerebral edema (HP:0002181)1.73609238
181Anencephaly (HP:0002323)1.73534605
182Overgrowth (HP:0001548)1.73144801
183Oligodactyly (hands) (HP:0001180)1.73023578
184Macrocytic anemia (HP:0001972)1.72749720
185Short nail (HP:0001799)1.72311395
186Partial duplication of the phalanx of hand (HP:0009999)1.71781579
187Hemivertebrae (HP:0002937)1.71459366
188Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.70961565
189Labial hypoplasia (HP:0000066)1.70697869
190Hyperextensible skin (HP:0000974)1.70657392
191Lissencephaly (HP:0001339)1.70484908
192Knee flexion contracture (HP:0006380)1.70472451
193Lymphangioma (HP:0100764)1.69413291
194Long toe (HP:0010511)1.69386367
195Hypoventilation (HP:0002791)1.68828664
196Abnormality of the radial head (HP:0003995)1.68186133
197Flat cornea (HP:0007720)1.66673825
198Flexion contracture of toe (HP:0005830)1.65227662
199Joint contractures involving the joints of the feet (HP:0100492)1.65227662

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.06282306
2ERBB35.02559659
3MAP3K44.12722270
4MAP2K73.89335284
5DDR23.79940439
6LATS23.72057629
7EPHA43.66575735
8EEF2K3.18268328
9MARK12.94977595
10ADRBK22.94270596
11STK162.89983368
12MAP3K102.84208376
13PDGFRA2.80893016
14GRK12.76886870
15TRIB32.65559759
16WNK32.36979855
17EPHB22.18388586
18LATS12.17898692
19MINK12.15536276
20PKN22.12446194
21MKNK12.12153013
22NTRK32.08814095
23MAP2K42.07618801
24NTRK21.90612411
25PAK21.85806183
26BCR1.84117968
27TLK11.83747166
28PLK41.81480085
29RPS6KA41.79178634
30BMPR21.78320365
31TRIM281.72214642
32LRRK21.66981090
33TTN1.66868378
34DYRK31.61536627
35TESK11.56674762
36VRK21.55713324
37LIMK11.52028260
38DYRK1B1.49397913
39BMX1.49357750
40SRPK11.45214891
41NEK91.44240787
42DYRK21.41940821
43CDK191.39078299
44SIK11.36825973
45MOS1.31342831
46MAP4K21.29603299
47PAK41.27169876
48ICK1.26341913
49ZAK1.23789228
50MATK1.18516065
51RIPK11.17761363
52TGFBR21.16282285
53STK241.15906403
54TESK21.15087815
55FGFR11.12320182
56ILK1.12291496
57MKNK21.11712626
58PRKCG1.11233455
59PTK21.05029978
60PLK30.99262566
61CDK50.99103404
62NEK20.99048711
63NME20.98940574
64PLK20.98458142
65PAK60.98051040
66ACVR1B0.96204384
67MET0.94443509
68CDC70.94345246
69FER0.93111843
70PTK60.91262388
71PINK10.89861439
72PASK0.86484305
73BMPR1B0.85191656
74TYRO30.80505167
75SGK4940.79345624
76SGK2230.79345624
77SIK20.79255722
78MTOR0.79219265
79PAK30.78922791
80CAMK1G0.77545656
81MAP3K90.77370109
82NME10.76757611
83UHMK10.76615017
84CSNK1A1L0.74563453
85MAPK130.73902255
86PLK10.72960376
87TAF10.72419259
88CDK140.71809700
89PAK10.71633012
90VRK10.71231532
91CDK60.70961150
92ROCK20.70921249
93TTK0.69317730
94BCKDK0.68105859
95ROCK10.67900426
96PTK2B0.67509675
97STK30.66826016
98PDGFRB0.65127685
99PHKG10.65031033
100PHKG20.65031033
101ERBB20.64452115
102CAMK1D0.63730999
103WNK10.62843153
104TRPM70.62394008
105TGFBR10.60229209
106WNK40.59796481
107CDK150.59688659
108ATR0.59185305
109PNCK0.59002374
110PRKD20.57368216
111CDK180.55474377
112DAPK30.54767857
113MAP3K110.54418997
114MAP3K80.54260863
115CDK80.53932872
116MAP3K50.53908511
117CDK11A0.53456213
118CSNK1G30.50845428
119AURKA0.50516747
120ARAF0.49432982
121BRAF0.49002324
122AURKB0.48533810
123SCYL20.47389787
124DYRK1A0.47389614
125KSR10.47246309
126STK110.44972196
127DAPK20.44607682
128MAP3K60.44283297
129SGK20.43108599
130MAPK150.42956885
131CSNK1A10.42700126
132EIF2AK10.42587666
133PRKACA0.42241723
134BUB10.42203722
135PIM20.42190715
136PRKG10.40122976
137INSR0.40016251
138CSNK1G10.39827962
139STK38L0.39791388
140CSNK1E0.39686601
141CSNK1G20.37805738
142CHEK20.37798939
143MAPK90.36321948
144ADRBK10.36000368
145CSNK2A20.35556411
146ERN10.35275655
147INSRR0.34369806
148FGFR20.34217897
149EPHA30.34201267
150TAOK10.32943299
151CHEK10.32885753
152NTRK10.32138024
153MAPKAPK20.31417626
154TIE10.30018516
155OXSR10.29416582
156CAMK10.29407788
157NUAK10.28654939
158CSNK2A10.27770818

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001905.04414059
2Parkinsons disease_Homo sapiens_hsa050124.57548864
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.25065586
4Huntingtons disease_Homo sapiens_hsa050163.00157227
5Alzheimers disease_Homo sapiens_hsa050102.96386976
6Basal cell carcinoma_Homo sapiens_hsa052172.90400910
7Ribosome_Homo sapiens_hsa030102.69707293
8Cardiac muscle contraction_Homo sapiens_hsa042602.58761571
9Hedgehog signaling pathway_Homo sapiens_hsa043402.51622721
10Protein export_Homo sapiens_hsa030602.34664444
11Adherens junction_Homo sapiens_hsa045202.34155000
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.32605687
13Hippo signaling pathway_Homo sapiens_hsa043902.31472918
14Proteoglycans in cancer_Homo sapiens_hsa052052.25096651
15Nicotine addiction_Homo sapiens_hsa050332.23685189
16Chronic myeloid leukemia_Homo sapiens_hsa052202.20881852
17Bladder cancer_Homo sapiens_hsa052192.17800050
18MicroRNAs in cancer_Homo sapiens_hsa052062.15977932
19ECM-receptor interaction_Homo sapiens_hsa045122.15652138
20TGF-beta signaling pathway_Homo sapiens_hsa043502.07734237
21Spliceosome_Homo sapiens_hsa030402.06018522
22Collecting duct acid secretion_Homo sapiens_hsa049662.02017394
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.95340235
24Focal adhesion_Homo sapiens_hsa045101.91362129
25AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.83130518
26Cell cycle_Homo sapiens_hsa041101.82059669
27p53 signaling pathway_Homo sapiens_hsa041151.78273673
28Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.77844228
29Synaptic vesicle cycle_Homo sapiens_hsa047211.76214974
30Axon guidance_Homo sapiens_hsa043601.75490277
31Colorectal cancer_Homo sapiens_hsa052101.71854895
32Melanoma_Homo sapiens_hsa052181.71409879
33Wnt signaling pathway_Homo sapiens_hsa043101.70013894
34Cocaine addiction_Homo sapiens_hsa050301.68284036
35Dopaminergic synapse_Homo sapiens_hsa047281.66339611
36Phototransduction_Homo sapiens_hsa047441.65815905
37RNA transport_Homo sapiens_hsa030131.63403471
38mRNA surveillance pathway_Homo sapiens_hsa030151.57029496
39Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.56004810
40Viral myocarditis_Homo sapiens_hsa054161.52741504
41GABAergic synapse_Homo sapiens_hsa047271.50502382
42Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.50249811
43Notch signaling pathway_Homo sapiens_hsa043301.48783583
44Glioma_Homo sapiens_hsa052141.46553344
45Small cell lung cancer_Homo sapiens_hsa052221.38175793
46One carbon pool by folate_Homo sapiens_hsa006701.38129065
47HTLV-I infection_Homo sapiens_hsa051661.36561084
48Pathways in cancer_Homo sapiens_hsa052001.33250952
49Prostate cancer_Homo sapiens_hsa052151.30598792
50PI3K-Akt signaling pathway_Homo sapiens_hsa041511.28804940
51Viral carcinogenesis_Homo sapiens_hsa052031.28524934
52Circadian entrainment_Homo sapiens_hsa047131.28040787
53Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.27931263
54Glutamatergic synapse_Homo sapiens_hsa047241.26433284
55Morphine addiction_Homo sapiens_hsa050321.25913848
56Basal transcription factors_Homo sapiens_hsa030221.25566558
57Tight junction_Homo sapiens_hsa045301.24470269
58Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.23046146
59Pancreatic cancer_Homo sapiens_hsa052121.21515587
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.17371192
61Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.14697398
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.14162198
63Alcoholism_Homo sapiens_hsa050341.13947545
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.10341766
65Melanogenesis_Homo sapiens_hsa049161.09907220
66DNA replication_Homo sapiens_hsa030301.09113812
67Amoebiasis_Homo sapiens_hsa051461.07540084
68Endometrial cancer_Homo sapiens_hsa052131.07329838
69Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.06062434
70Systemic lupus erythematosus_Homo sapiens_hsa053221.05865273
71Vibrio cholerae infection_Homo sapiens_hsa051101.03299764
72Serotonergic synapse_Homo sapiens_hsa047261.02457006
73Thyroid cancer_Homo sapiens_hsa052161.00956934
74Rap1 signaling pathway_Homo sapiens_hsa040151.00033835
75Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99819716
76Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98635874
77Shigellosis_Homo sapiens_hsa051310.98531851
78Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.98235660
79Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.98120008
80Homologous recombination_Homo sapiens_hsa034400.97136282
81Central carbon metabolism in cancer_Homo sapiens_hsa052300.96461157
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.96255298
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.95126389
84Long-term depression_Homo sapiens_hsa047300.92078258
85Butanoate metabolism_Homo sapiens_hsa006500.88617794
86Regulation of autophagy_Homo sapiens_hsa041400.87305006
87Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87248035
88Cholinergic synapse_Homo sapiens_hsa047250.83585978
89FoxO signaling pathway_Homo sapiens_hsa040680.83303882
90Taste transduction_Homo sapiens_hsa047420.81043139
91Gap junction_Homo sapiens_hsa045400.80959179
92Hepatitis B_Homo sapiens_hsa051610.80903830
93Proteasome_Homo sapiens_hsa030500.80155108
94Epstein-Barr virus infection_Homo sapiens_hsa051690.77944291
95Dilated cardiomyopathy_Homo sapiens_hsa054140.77686957
96TNF signaling pathway_Homo sapiens_hsa046680.77197849
97Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.77002933
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.75355875
99Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75035382
100Non-small cell lung cancer_Homo sapiens_hsa052230.74668247
101ErbB signaling pathway_Homo sapiens_hsa040120.73581382
102Renal cell carcinoma_Homo sapiens_hsa052110.73426545
103Malaria_Homo sapiens_hsa051440.72926368
104Regulation of actin cytoskeleton_Homo sapiens_hsa048100.72645544
105Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.72296381
106Oocyte meiosis_Homo sapiens_hsa041140.71535071
107Pyrimidine metabolism_Homo sapiens_hsa002400.69978719
108Peroxisome_Homo sapiens_hsa041460.69660281
109Non-homologous end-joining_Homo sapiens_hsa034500.68726300
110Protein digestion and absorption_Homo sapiens_hsa049740.68199640
111Renin-angiotensin system_Homo sapiens_hsa046140.67531409
112Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.66816858
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.66162073
114Leukocyte transendothelial migration_Homo sapiens_hsa046700.66061685
115Apoptosis_Homo sapiens_hsa042100.65923890
116Pyruvate metabolism_Homo sapiens_hsa006200.65903362
117Ras signaling pathway_Homo sapiens_hsa040140.65153764
118Nucleotide excision repair_Homo sapiens_hsa034200.64262279
119Base excision repair_Homo sapiens_hsa034100.63280112
120Steroid biosynthesis_Homo sapiens_hsa001000.62700546
121GnRH signaling pathway_Homo sapiens_hsa049120.62067049
122Olfactory transduction_Homo sapiens_hsa047400.61795060
123Estrogen signaling pathway_Homo sapiens_hsa049150.61393380
124Purine metabolism_Homo sapiens_hsa002300.60150242
125Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.58840173
126Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.58430690
127mTOR signaling pathway_Homo sapiens_hsa041500.57616718
128RNA polymerase_Homo sapiens_hsa030200.56965769
129Metabolic pathways_Homo sapiens_hsa011000.56519280
130Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56157685
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.55840324
132Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55512514
133Nitrogen metabolism_Homo sapiens_hsa009100.55121734
134Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54103711
135VEGF signaling pathway_Homo sapiens_hsa043700.52871195
136Phagosome_Homo sapiens_hsa041450.51229270
137Sulfur relay system_Homo sapiens_hsa041220.50796262
138Fanconi anemia pathway_Homo sapiens_hsa034600.50610954
139MAPK signaling pathway_Homo sapiens_hsa040100.47482970
140Amphetamine addiction_Homo sapiens_hsa050310.46270640
141Mismatch repair_Homo sapiens_hsa034300.45685861
142Prion diseases_Homo sapiens_hsa050200.43529581
143Insulin secretion_Homo sapiens_hsa049110.42619669
144N-Glycan biosynthesis_Homo sapiens_hsa005100.40058994
145Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.38942045
146RNA degradation_Homo sapiens_hsa030180.38685165
147Insulin signaling pathway_Homo sapiens_hsa049100.37493750
148Folate biosynthesis_Homo sapiens_hsa007900.37033218
149Prolactin signaling pathway_Homo sapiens_hsa049170.36790777
150Longevity regulating pathway - mammal_Homo sapiens_hsa042110.36308855
151Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.34578209
152Vitamin B6 metabolism_Homo sapiens_hsa007500.34513130
153Cyanoamino acid metabolism_Homo sapiens_hsa004600.34055600
154Propanoate metabolism_Homo sapiens_hsa006400.33708092
155Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.33518406
156Gastric acid secretion_Homo sapiens_hsa049710.33221439
157cAMP signaling pathway_Homo sapiens_hsa040240.30548063
158Retinol metabolism_Homo sapiens_hsa008300.28590773
159Linoleic acid metabolism_Homo sapiens_hsa005910.21083043
160Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.18943605
161Cysteine and methionine metabolism_Homo sapiens_hsa002700.17322777
162Oxytocin signaling pathway_Homo sapiens_hsa049210.16976198
163Fatty acid elongation_Homo sapiens_hsa000620.13541182
164Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.12587028

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