CRABP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1notochord development (GO:0030903)4.96738823
2paraxial mesoderm development (GO:0048339)4.86085714
3outer ear morphogenesis (GO:0042473)4.75124259
4negative regulation of epidermis development (GO:0045683)4.74900189
5vitamin catabolic process (GO:0009111)4.70097865
6fat-soluble vitamin catabolic process (GO:0042363)4.70097865
7protein localization to kinetochore (GO:0034501)4.63862856
8pre-miRNA processing (GO:0031054)4.57554756
9regulation of water loss via skin (GO:0033561)4.53047575
10establishment of skin barrier (GO:0061436)4.48585387
11positive regulation of cell size (GO:0045793)4.33377356
12positive regulation of glomerulus development (GO:0090193)4.29836770
13enteric nervous system development (GO:0048484)4.29210557
14planar cell polarity pathway involved in neural tube closure (GO:0090179)4.14215433
15COPI coating of Golgi vesicle (GO:0048205)4.13140422
16Golgi transport vesicle coating (GO:0048200)4.13140422
17DNA replication-dependent nucleosome assembly (GO:0006335)3.99141203
18DNA replication-dependent nucleosome organization (GO:0034723)3.99141203
19positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)3.91400929
20heterochromatin organization (GO:0070828)3.89882918
21regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.81812029
22regulation of posttranscriptional gene silencing (GO:0060147)3.77937608
23regulation of gene silencing by miRNA (GO:0060964)3.77937608
24regulation of gene silencing by RNA (GO:0060966)3.77937608
25mitotic sister chromatid segregation (GO:0000070)3.76514567
26regulation of mammary gland epithelial cell proliferation (GO:0033599)3.75914320
27somite rostral/caudal axis specification (GO:0032525)3.75664476
28regulation of cardioblast differentiation (GO:0051890)3.74571074
29nuclear pore complex assembly (GO:0051292)3.67441472
30proximal/distal pattern formation (GO:0009954)3.66564482
31daunorubicin metabolic process (GO:0044597)3.66347552
32polyketide metabolic process (GO:0030638)3.66347552
33doxorubicin metabolic process (GO:0044598)3.66347552
34sister chromatid segregation (GO:0000819)3.65766430
35bone trabecula formation (GO:0060346)3.63099385
36neuron projection extension involved in neuron projection guidance (GO:1902284)3.62961847
37axon extension involved in axon guidance (GO:0048846)3.62961847
38nuclear pore organization (GO:0006999)3.62885365
39protein localization to chromosome, centromeric region (GO:0071459)3.62554915
40desmosome organization (GO:0002934)3.59500527
41lateral sprouting from an epithelium (GO:0060601)3.59348193
42negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)3.56969359
43chromatin assembly (GO:0031497)3.52759605
44protein retention in ER lumen (GO:0006621)3.50987645
45regulation of glomerulus development (GO:0090192)3.47666404
46negative regulation of epidermal cell differentiation (GO:0045605)3.45858273
47negative regulation of cell fate specification (GO:0009996)3.43146708
48regulation of telomere maintenance via telomerase (GO:0032210)3.40183638
49DNA unwinding involved in DNA replication (GO:0006268)3.37621951
50maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.34971655
51cochlea morphogenesis (GO:0090103)3.34344445
52DNA replication checkpoint (GO:0000076)3.29959428
53mRNA stabilization (GO:0048255)3.25152951
54RNA stabilization (GO:0043489)3.25152951
55negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)3.24548896
56regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.24424294
57negative regulation of cell cycle G2/M phase transition (GO:1902750)3.18311988
58retinoic acid receptor signaling pathway (GO:0048384)3.15690650
59regulation of nuclear cell cycle DNA replication (GO:0033262)3.15273790
60hindlimb morphogenesis (GO:0035137)3.11447720
61embryonic hindlimb morphogenesis (GO:0035116)3.09983327
62innervation (GO:0060384)3.09553041
63sympathetic nervous system development (GO:0048485)3.08400246
64primitive streak formation (GO:0090009)3.05850304
65regulation of hippo signaling (GO:0035330)3.05198338
66cell proliferation involved in metanephros development (GO:0072203)3.02231974
67G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071993.00911549
68positive regulation of transcription regulatory region DNA binding (GO:2000679)2.98886748
69ear development (GO:0043583)2.96152329
70mesenchymal cell proliferation (GO:0010463)2.93949804
71dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.93340368
72polarized epithelial cell differentiation (GO:0030859)2.91846162
73regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.90252301
74Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.89515746
75regulation of apoptotic process involved in morphogenesis (GO:1902337)2.88744514
76bone morphogenesis (GO:0060349)2.87527242
77rRNA transcription (GO:0009303)2.85537580
78middle ear morphogenesis (GO:0042474)2.83940882
79negative regulation of cell fate commitment (GO:0010454)2.83041940
80histone H4-K8 acetylation (GO:0043982)2.82024520
81histone H4-K5 acetylation (GO:0043981)2.82024520
82negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.81146847
83cranial nerve structural organization (GO:0021604)2.80780202
84formation of translation preinitiation complex (GO:0001731)2.80387283
85positive regulation of smoothened signaling pathway (GO:0045880)2.79125009
86artery development (GO:0060840)2.76623110
87establishment of tissue polarity (GO:0007164)2.75845750
88establishment of planar polarity (GO:0001736)2.75845750
89non-canonical Wnt signaling pathway (GO:0035567)2.75543812
90positive regulation of DNA-dependent DNA replication (GO:2000105)2.75373715
91mitotic chromosome condensation (GO:0007076)2.75252724
92regulation of establishment of planar polarity (GO:0090175)2.75213661
93hippo signaling (GO:0035329)2.74874371
94pore complex assembly (GO:0046931)2.74726633
95embryonic skeletal joint morphogenesis (GO:0060272)2.74455739
96establishment of apical/basal cell polarity (GO:0035089)2.74366782
97muscle organ morphogenesis (GO:0048644)2.74236025
98mammary gland epithelial cell differentiation (GO:0060644)2.72977210
99neural crest cell migration (GO:0001755)2.72318397
100negative regulation of striated muscle cell apoptotic process (GO:0010664)2.71831915
101mitotic metaphase plate congression (GO:0007080)2.71555605
102multicellular organismal water homeostasis (GO:0050891)2.71041763
103regulation of hair follicle development (GO:0051797)2.70880395
104DNA damage response, detection of DNA damage (GO:0042769)2.70742727
105facial nerve structural organization (GO:0021612)2.70436026
106eyelid development in camera-type eye (GO:0061029)2.69645027
107regulation of cell maturation (GO:1903429)2.69095853
108establishment of integrated proviral latency (GO:0075713)2.68894710
109anterior/posterior axis specification (GO:0009948)2.68456631
110regulation of response to osmotic stress (GO:0047484)2.68377294
111negative regulation of chondrocyte differentiation (GO:0032331)2.68187094
112anatomical structure arrangement (GO:0048532)2.66321844
113vitamin A metabolic process (GO:0006776)2.65502785
114branching involved in salivary gland morphogenesis (GO:0060445)2.65472103
115embryonic skeletal system morphogenesis (GO:0048704)2.64609137
116semaphorin-plexin signaling pathway (GO:0071526)2.63990735
117peptidyl-arginine methylation (GO:0018216)2.63396110
118peptidyl-arginine N-methylation (GO:0035246)2.63396110
119norepinephrine metabolic process (GO:0042415)2.62820832
120retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.62031473
121embryonic camera-type eye development (GO:0031076)2.61785472
122face development (GO:0060324)2.61655874
123cullin deneddylation (GO:0010388)2.61637133
124positive regulation of hair follicle development (GO:0051798)2.61357428
125positive regulation of hair cycle (GO:0042635)2.61357428
126cell fate commitment involved in formation of primary germ layer (GO:0060795)2.61286833
127outflow tract septum morphogenesis (GO:0003148)2.60212624
128negative regulation of telomerase activity (GO:0051974)2.59995222
129negative regulation of DNA repair (GO:0045738)2.59669779
130regulation of odontogenesis of dentin-containing tooth (GO:0042487)2.59165991
131DNA duplex unwinding (GO:0032508)2.58737033
132positive regulation of gastrulation (GO:2000543)2.58055159
133DNA geometric change (GO:0032392)2.57294409
134positive regulation of skeletal muscle tissue development (GO:0048643)2.57040547
135mitotic nuclear envelope disassembly (GO:0007077)2.56502017
136negative regulation of embryonic development (GO:0045992)2.55489231
137regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.54999679
138cardiovascular system development (GO:0072358)2.53694446
139lung-associated mesenchyme development (GO:0060484)2.53690480
140positive regulation of keratinocyte differentiation (GO:0045618)2.53160839
141peptidyl-arginine omega-N-methylation (GO:0035247)2.52845434
142convergent extension (GO:0060026)2.51477784
143histone arginine methylation (GO:0034969)2.50881171
144ectoderm development (GO:0007398)2.50768134
145negative regulation of transcription by competitive promoter binding (GO:0010944)2.48857653
146establishment or maintenance of monopolar cell polarity (GO:0061339)2.48516391
147establishment of monopolar cell polarity (GO:0061162)2.48516391
148regulation of cardioblast proliferation (GO:0003264)2.48379204
149regulation of secondary heart field cardioblast proliferation (GO:0003266)2.48379204
150negative regulation of cartilage development (GO:0061037)2.47550281
151nucleosome disassembly (GO:0006337)2.46707438
152protein-DNA complex disassembly (GO:0032986)2.46707438
153maternal placenta development (GO:0001893)2.46331675
154regulation of sister chromatid cohesion (GO:0007063)2.46098167
155cell migration in hindbrain (GO:0021535)2.45960336
156cell surface receptor signaling pathway involved in heart development (GO:0061311)2.45760706
157chromatin assembly or disassembly (GO:0006333)2.43655756
158positive regulation of epidermis development (GO:0045684)2.43430082
159protein deneddylation (GO:0000338)2.43091334
160regulation of heart morphogenesis (GO:2000826)2.36650283
161proline biosynthetic process (GO:0006561)2.35563274
162nuclear envelope reassembly (GO:0031468)2.34809188
163mitotic nuclear envelope reassembly (GO:0007084)2.34809188
164negative regulation of axon extension involved in axon guidance (GO:0048843)2.34622369
165amyloid precursor protein catabolic process (GO:0042987)2.33801080
166ureteric bud development (GO:0001657)2.32991890
167mesonephros development (GO:0001823)2.32450219
168positive regulation of metanephros development (GO:0072216)2.31423384
169bundle of His cell to Purkinje myocyte communication (GO:0086069)2.31384365
170branching involved in mammary gland duct morphogenesis (GO:0060444)2.31007468

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.44363630
2TP63_19390658_ChIP-ChIP_HaCaT_Human4.30127555
3KLF2_18264089_ChIP-ChIP_MESCs_Mouse4.25802861
4KLF5_18264089_ChIP-ChIP_MESCs_Mouse4.25802861
5KLF4_18264089_ChIP-ChIP_MESCs_Mouse4.25802861
6TP63_17297297_ChIP-ChIP_HaCaT_Human4.03197191
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.79185118
8TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.67176404
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.55334202
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.88564056
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.79821278
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.78549414
13* ESR1_21235772_ChIP-Seq_MCF-7_Human2.63200049
14BP1_19119308_ChIP-ChIP_Hs578T_Human2.58490735
15NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.52061081
16MYC_18555785_ChIP-Seq_MESCs_Mouse2.49696313
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.48407114
18ESR2_21235772_ChIP-Seq_MCF-7_Human2.43574792
19* RACK7_27058665_Chip-Seq_MCF-7_Human2.25909344
20TCF3_18692474_ChIP-Seq_MEFs_Mouse2.23529906
21SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.20769826
22SOX2_18555785_ChIP-Seq_MESCs_Mouse2.20573168
23* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.16147439
24ZNF263_19887448_ChIP-Seq_K562_Human2.15093427
25POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.09627430
26TCF3_18692474_ChIP-Seq_MESCs_Mouse2.04442939
27MYC_19079543_ChIP-ChIP_MESCs_Mouse2.02804416
28SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.98021046
29ERG_21242973_ChIP-ChIP_JURKAT_Human1.95424505
30NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.91587292
31ESR1_20079471_ChIP-ChIP_T-47D_Human1.91523921
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.88740009
33ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.87593703
34POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.87294147
35* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.85963208
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.84996758
37KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.81496003
38EGR1_19374776_ChIP-ChIP_THP-1_Human1.78912327
39SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.77248772
40KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.74609893
41NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.72726870
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.72417725
43MYC_19030024_ChIP-ChIP_MESCs_Mouse1.72281450
44POU5F1_16153702_ChIP-ChIP_HESCs_Human1.70690458
45MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.70174213
46AR_21909140_ChIP-Seq_LNCAP_Human1.67110563
47TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.63781745
48KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.63566326
49NANOG_16153702_ChIP-ChIP_HESCs_Human1.62361836
50SALL1_21062744_ChIP-ChIP_HESCs_Human1.62114235
51TP53_20018659_ChIP-ChIP_R1E_Mouse1.60469561
52MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.59244187
53TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.55916197
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.55581378
55JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.53872777
56* ZFP281_27345836_Chip-Seq_ESCs_Mouse1.53398184
57EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.52919089
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.51314386
59DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.51008336
60STAT6_21828071_ChIP-Seq_BEAS2B_Human1.49374600
61XRN2_22483619_ChIP-Seq_HELA_Human1.47242975
62TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.45545664
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.44479083
64* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.43913522
65* TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.42097910
66THAP11_20581084_ChIP-Seq_MESCs_Mouse1.41932148
67NELFA_20434984_ChIP-Seq_ESCs_Mouse1.41783499
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.41466627
69RUNX1_27514584_Chip-Seq_MCF-7_Human1.39972358
70* LXR_22292898_ChIP-Seq_THP-1_Human1.39441863
71RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38273044
72CLOCK_20551151_ChIP-Seq_293T_Human1.37710499
73* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37105445
74NANOG_21062744_ChIP-ChIP_HESCs_Human1.36923283
75NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.34796141
76HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.33251152
77EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.31333667
78TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.31209183
79CREB1_15753290_ChIP-ChIP_HEK293T_Human1.29522853
80SOX2_18692474_ChIP-Seq_MEFs_Mouse1.29501188
81MYCN_18555785_ChIP-Seq_MESCs_Mouse1.28325730
82* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.28191997
83OCT4_18692474_ChIP-Seq_MEFs_Mouse1.26505256
84* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24945745
85MYC_18358816_ChIP-ChIP_MESCs_Mouse1.22769803
86NANOG_18555785_ChIP-Seq_MESCs_Mouse1.22682920
87TTF2_22483619_ChIP-Seq_HELA_Human1.22406184
88* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.22132108
89TET1_21451524_ChIP-Seq_MESCs_Mouse1.20382913
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.18672427
91MYC_22102868_ChIP-Seq_BL_Human1.17241619
92ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.16863697
93NANOG_18692474_ChIP-Seq_MEFs_Mouse1.16728004
94KDM5A_27292631_Chip-Seq_BREAST_Human1.16442523
95SOX2_18692474_ChIP-Seq_MESCs_Mouse1.15442279
96DCP1A_22483619_ChIP-Seq_HELA_Human1.14035449
97CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14022895
98ATF3_27146783_Chip-Seq_COLON_Human1.13034939
99POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.11752844
100CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.11438605
101RING1B_27294783_Chip-Seq_NPCs_Mouse1.10856769
102ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.10387378
103GABP_19822575_ChIP-Seq_HepG2_Human1.09648784
104POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.08969872
105STAT3_1855785_ChIP-Seq_MESCs_Mouse1.08279786
106ETS1_20019798_ChIP-Seq_JURKAT_Human1.07846531
107ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06847867
108POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.06837945
109FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05925466
110ESR1_15608294_ChIP-ChIP_MCF-7_Human1.05816630
111* SA1_27219007_Chip-Seq_ERYTHROID_Human1.05497504
112KDM2B_26808549_Chip-Seq_K562_Human1.05368883
113HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05024603
114SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.04526139
115PRDM14_21183938_ChIP-Seq_MESCs_Mouse1.04089078
116TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse1.04035048
117NANOG_18692474_ChIP-Seq_MESCs_Mouse1.03933366
118CTCF_18555785_ChIP-Seq_MESCs_Mouse1.03630519
119BMI1_23680149_ChIP-Seq_NPCS_Mouse1.03071712
120KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02764092
121CDX2_20551321_ChIP-Seq_CACO-2_Human1.01991762
122SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.01252335
123SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00988812
124GABP_17652178_ChIP-ChIP_JURKAT_Human1.00735402
125E2F1_18555785_ChIP-Seq_MESCs_Mouse1.00647313
126KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.00244553
127P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00064373
128WT1_19549856_ChIP-ChIP_CCG9911_Human0.99990922
129CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.98822677
130TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.98526168
131SRY_22984422_ChIP-ChIP_TESTIS_Rat0.98257523
132TP53_22127205_ChIP-Seq_IMR90_Human0.97655071
133GATA3_24758297_ChIP-Seq_MCF-7_Human0.96939458
134* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.96791544
135* FOXP1_21924763_ChIP-Seq_HESCs_Human0.95643119
136TRIM28_21343339_ChIP-Seq_HEK293_Human0.95161682
137* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.95029864
138E2F1_21310950_ChIP-Seq_MCF-7_Human0.94736988
139RNF2_27304074_Chip-Seq_NSC_Mouse0.94107117
140ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91463898
141CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.88428956
142KLF4_18555785_ChIP-Seq_MESCs_Mouse0.87324412
143ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.86429111
144* RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86205974
145EST1_17652178_ChIP-ChIP_JURKAT_Human0.85388689
146RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.84911222
147YY1_21170310_ChIP-Seq_MESCs_Mouse0.84662985
148PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.83515538
149* ELK3_25401928_ChIP-Seq_HUVEC_Human0.82522605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.64487750
2MP0010234_abnormal_vibrissa_follicle3.06839240
3MP0009053_abnormal_anal_canal2.96896054
4MP0005499_abnormal_olfactory_system2.84815730
5MP0005394_taste/olfaction_phenotype2.84815730
6MP0003705_abnormal_hypodermis_morpholog2.69829854
7MP0008789_abnormal_olfactory_epithelium2.53603911
8MP0000049_abnormal_middle_ear2.42557319
9MP0002249_abnormal_larynx_morphology2.31331084
10MP0003122_maternal_imprinting2.30802355
11MP0000678_abnormal_parathyroid_gland2.25205404
12MP0000537_abnormal_urethra_morphology2.19570135
13MP0003123_paternal_imprinting2.14463614
14MP0006292_abnormal_olfactory_placode2.14446557
15MP0003121_genomic_imprinting2.11168310
16MP0003315_abnormal_perineum_morphology2.10254866
17MP0000566_synostosis2.06166271
18MP0003890_abnormal_embryonic-extraembry2.05001760
19MP0003937_abnormal_limbs/digits/tail_de2.04338957
20MP0009250_abnormal_appendicular_skeleto2.03542776
21MP0000762_abnormal_tongue_morphology1.99821778
22MP0002653_abnormal_ependyma_morphology1.98131805
23MP0005248_abnormal_Harderian_gland1.96075882
24MP0003011_delayed_dark_adaptation1.95894855
25MP0003385_abnormal_body_wall1.95783418
26MP0002233_abnormal_nose_morphology1.88972099
27MP0003755_abnormal_palate_morphology1.87795140
28MP0003938_abnormal_ear_development1.87444119
29MP0002932_abnormal_joint_morphology1.86034656
30MP0004957_abnormal_blastocyst_morpholog1.80229714
31MP0003942_abnormal_urinary_system1.77527217
32MP0002822_catalepsy1.75665402
33MP0003941_abnormal_skin_development1.71886738
34MP0010352_gastrointestinal_tract_polyps1.70122129
35MP0001849_ear_inflammation1.67751024
36MP0002282_abnormal_trachea_morphology1.63659277
37MP0003878_abnormal_ear_physiology1.59271926
38MP0005377_hearing/vestibular/ear_phenot1.59271926
39MP0000428_abnormal_craniofacial_morphol1.58795889
40MP0004264_abnormal_extraembryonic_tissu1.57340305
41MP0005257_abnormal_intraocular_pressure1.54947690
42MP0001293_anophthalmia1.50303741
43MP0000462_abnormal_digestive_system1.47175594
44MP0003935_abnormal_craniofacial_develop1.46986232
45MP0008932_abnormal_embryonic_tissue1.44709545
46MP0005508_abnormal_skeleton_morphology1.42822762
47MP0003119_abnormal_digestive_system1.42033054
48MP0002085_abnormal_embryonic_tissue1.40910772
49MP0002254_reproductive_system_inflammat1.40636773
50MP0003077_abnormal_cell_cycle1.40498075
51MP0005275_abnormal_skin_tensile1.40224952
52MP0000579_abnormal_nail_morphology1.39660677
53MP0000534_abnormal_ureter_morphology1.38669011
54MP0002796_impaired_skin_barrier1.38499143
55MP0002116_abnormal_craniofacial_bone1.37819124
56MP0000538_abnormal_urinary_bladder1.36771782
57MP0002938_white_spotting1.36665435
58MP0002098_abnormal_vibrissa_morphology1.34401590
59MP0001672_abnormal_embryogenesis/_devel1.34233651
60MP0005380_embryogenesis_phenotype1.34233651
61MP0000432_abnormal_head_morphology1.33723340
62MP0004197_abnormal_fetal_growth/weight/1.32714751
63MP0002060_abnormal_skin_morphology1.31611122
64MP0000350_abnormal_cell_proliferation1.29523966
65MP0000613_abnormal_salivary_gland1.29217238
66MP0002114_abnormal_axial_skeleton1.29062986
67MP0000467_abnormal_esophagus_morphology1.28203435
68MP0002084_abnormal_developmental_patter1.27670126
69MP0008007_abnormal_cellular_replicative1.27423032
70MP0003111_abnormal_nucleus_morphology1.27373917
71MP0002111_abnormal_tail_morphology1.24917650
72MP0002092_abnormal_eye_morphology1.24455418
73MP0001299_abnormal_eye_distance/1.20259427
74MP0008057_abnormal_DNA_replication1.19395008
75MP0001340_abnormal_eyelid_morphology1.18653877
76MP0002088_abnormal_embryonic_growth/wei1.17245266
77MP0003984_embryonic_growth_retardation1.15667690
78MP0000681_abnormal_thyroid_gland1.15602007
79MP0000383_abnormal_hair_follicle1.15100734
80MP0001286_abnormal_eye_development1.13356659
81MP0000516_abnormal_urinary_system1.12956047
82MP0005367_renal/urinary_system_phenotyp1.12956047
83MP0005083_abnormal_biliary_tract1.11499069
84MP0002697_abnormal_eye_size1.10212278
85MP0010094_abnormal_chromosome_stability1.09793611
86MP0009384_cardiac_valve_regurgitation1.08485862
87MP0002109_abnormal_limb_morphology1.07996749
88MP0009672_abnormal_birth_weight1.06069924
89MP0000647_abnormal_sebaceous_gland1.05342878
90MP0005501_abnormal_skin_physiology1.04967189
91MP0003566_abnormal_cell_adhesion1.02859591
92MP0003693_abnormal_embryo_hatching1.01176417
93MP0005023_abnormal_wound_healing1.01092870
94MP0004858_abnormal_nervous_system1.00782136
95MP0001216_abnormal_epidermal_layer1.00064043
96MP0005187_abnormal_penis_morphology0.99686633
97MP0002177_abnormal_outer_ear0.99047039
98MP0001348_abnormal_lacrimal_gland0.97992767
99MP0005076_abnormal_cell_differentiation0.97867865
100MP0002751_abnormal_autonomic_nervous0.96418858
101MP0000733_abnormal_muscle_development0.95975364
102MP0002184_abnormal_innervation0.95573863
103MP0000163_abnormal_cartilage_morphology0.95284891
104MP0008438_abnormal_cutaneous_collagen0.95062166
105MP0003115_abnormal_respiratory_system0.94453560
106MP0001697_abnormal_embryo_size0.94187038
107MP0005623_abnormal_meninges_morphology0.94039156
108MP0002108_abnormal_muscle_morphology0.93037121
109MP0000377_abnormal_hair_follicle0.92691353
110MP0003861_abnormal_nervous_system0.92439855
111MP0001346_abnormal_lacrimal_gland0.92114317
112MP0001270_distended_abdomen0.91946903
113MP0000627_abnormal_mammary_gland0.90259053
114MP0005503_abnormal_tendon_morphology0.90141702
115MP0010678_abnormal_skin_adnexa0.89852752
116MP0002086_abnormal_extraembryonic_tissu0.89814619
117MP0010771_integument_phenotype0.88875110
118MP0001730_embryonic_growth_arrest0.86180395
119MP0002081_perinatal_lethality0.85474202
120MP0009703_decreased_birth_body0.83980999
121MP0000427_abnormal_hair_cycle0.83612515
122MP0004272_abnormal_basement_membrane0.81568566
123MP0002009_preneoplasia0.81347146
124MP0005197_abnormal_uvea_morphology0.79730116
125MP0001881_abnormal_mammary_gland0.78041098
126MP0003453_abnormal_keratinocyte_physiol0.69697947

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)4.68360328
2Abnormality of the parathyroid morphology (HP:0011766)4.11924934
3Hepatoblastoma (HP:0002884)4.07927621
4Humeroradial synostosis (HP:0003041)3.96036288
5Synostosis involving the elbow (HP:0003938)3.96036288
6Pheochromocytoma (HP:0002666)3.72319801
7Bicornuate uterus (HP:0000813)3.69432141
8Premature rupture of membranes (HP:0001788)3.49027408
9Oligodactyly (HP:0012165)3.46862157
10Bowel diverticulosis (HP:0005222)3.44218984
11Rib fusion (HP:0000902)3.41117134
12Renal duplication (HP:0000075)3.25530152
13Neuroendocrine neoplasm (HP:0100634)3.15432581
14Cervical subluxation (HP:0003308)3.10303040
15Abnormality of the phalanges of the hallux (HP:0010057)3.01868541
16Bifid tongue (HP:0010297)2.99780340
17Hyperparathyroidism (HP:0000843)2.99124884
18Failure to thrive in infancy (HP:0001531)2.95791253
19Occipital encephalocele (HP:0002085)2.89341681
20Abnormal lung lobation (HP:0002101)2.89213389
21Renal dysplasia (HP:0000110)2.87414170
22Short 5th finger (HP:0009237)2.86011394
23Hypoventilation (HP:0002791)2.85911217
24Short middle phalanx of the 5th finger (HP:0004220)2.85182678
25Hyperacusis (HP:0010780)2.78111757
26Nephroblastoma (Wilms tumor) (HP:0002667)2.74694150
27Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.67102807
28Short 4th metacarpal (HP:0010044)2.67102807
29Abnormality of calcium-phosphate metabolism (HP:0100530)2.65228498
30Disproportionate tall stature (HP:0001519)2.63837565
31Embryonal renal neoplasm (HP:0011794)2.63710360
32Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.62204770
33Partial duplication of the phalanx of hand (HP:0009999)2.58620153
34Rhabdomyosarcoma (HP:0002859)2.57727888
35Multiple enchondromatosis (HP:0005701)2.57566937
36Abnormality of the distal phalanx of the thumb (HP:0009617)2.54906464
37Neoplasm of striated muscle (HP:0009728)2.52109494
38Abnormality of nail color (HP:0100643)2.48540588
39Hypercortisolism (HP:0001578)2.42288863
40Concave nail (HP:0001598)2.38056633
41Abnormality of the 4th metacarpal (HP:0010012)2.37309746
42Ependymoma (HP:0002888)2.37004929
43Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.36071717
44Bladder diverticulum (HP:0000015)2.35153465
45Diastasis recti (HP:0001540)2.34304752
46Atresia of the external auditory canal (HP:0000413)2.32593089
47Preauricular skin tag (HP:0000384)2.32454473
48Fused cervical vertebrae (HP:0002949)2.27336879
49Mesomelia (HP:0003027)2.23912116
50Broad metatarsal (HP:0001783)2.23607779
51Abnormality of dentin (HP:0010299)2.22384675
52Broad toe (HP:0001837)2.22151561
53Potter facies (HP:0002009)2.21432122
54Facial shape deformation (HP:0011334)2.21432122
55Pili torti (HP:0003777)2.21208610
56Coronal craniosynostosis (HP:0004440)2.17790199
57Overriding aorta (HP:0002623)2.17662540
58Broad thumb (HP:0011304)2.17215737
59Hypercalcemia (HP:0003072)2.16543668
60Aplasia/Hypoplasia of the sternum (HP:0006714)2.16469053
61Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.16348551
62Selective tooth agenesis (HP:0001592)2.14517705
63Hypoplastic labia majora (HP:0000059)2.13567950
64Partial duplication of thumb phalanx (HP:0009944)2.13533406
65Ankle contracture (HP:0006466)2.12622610
66Adducted thumb (HP:0001181)2.11823041
67Skin tags (HP:0010609)2.11772544
68Neoplasm of the peripheral nervous system (HP:0100007)2.09530730
69Large earlobe (HP:0009748)2.09038799
70Shallow orbits (HP:0000586)2.08681587
71Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.07584682
72Supernumerary ribs (HP:0005815)2.06394453
73Natal tooth (HP:0000695)2.06262211
74Rectovaginal fistula (HP:0000143)2.05637694
75Rectal fistula (HP:0100590)2.05637694
76Short middle phalanx of finger (HP:0005819)2.03908819
77Exostoses (HP:0100777)2.02856361
78Right ventricular cardiomyopathy (HP:0011663)2.01607375
79Preauricular pit (HP:0004467)2.01057271
80Periauricular skin pits (HP:0100277)2.01057271
81Sparse lateral eyebrow (HP:0005338)1.99333537
82Preaxial foot polydactyly (HP:0001841)1.99288102
83Abnormality of the distal phalanges of the toes (HP:0010182)1.96755720
84Septate vagina (HP:0001153)1.96716548
85Abnormality of the nasolacrimal system (HP:0000614)1.96356677
86Trismus (HP:0000211)1.96265079
87Bell-shaped thorax (HP:0001591)1.95977122
88Abnormality of the lacrimal duct (HP:0011481)1.95649680
89Esophageal atresia (HP:0002032)1.94818774
90Abnormality of the labia majora (HP:0012881)1.94698659
91Asymmetry of the thorax (HP:0001555)1.94547542
92Aplasia/Hypoplasia of the sacrum (HP:0008517)1.93910103
93Facial cleft (HP:0002006)1.93209925
94Abnormality of the phalanges of the 5th finger (HP:0004213)1.92713899
95Synostosis of carpal bones (HP:0005048)1.90885598
96Astrocytoma (HP:0009592)1.90806172
97Abnormality of the astrocytes (HP:0100707)1.90806172
98Anophthalmia (HP:0000528)1.90732435
99Aplasia/hypoplasia of the humerus (HP:0006507)1.89395789
100Pterygium (HP:0001059)1.89303173
101Increased nuchal translucency (HP:0010880)1.89097708
102Carpal synostosis (HP:0009702)1.88979124
103Nasolacrimal duct obstruction (HP:0000579)1.88825123
104Vaginal fistula (HP:0004320)1.88695176
105Long palpebral fissure (HP:0000637)1.88486945
106Supernumerary bones of the axial skeleton (HP:0009144)1.88323591
107Congenital ichthyosiform erythroderma (HP:0007431)1.88170247
108Hypochromic microcytic anemia (HP:0004840)1.88055497
109Bifid scrotum (HP:0000048)1.86161251
110Soft skin (HP:0000977)1.85636698
111Missing ribs (HP:0000921)1.85581682
112Chromosomal breakage induced by crosslinking agents (HP:0003221)1.85367438
113Congenital glaucoma (HP:0001087)1.84850816
114Thin bony cortex (HP:0002753)1.84716234
115Broad phalanges of the hand (HP:0009768)1.83595392
116Abnormality of the lower motor neuron (HP:0002366)1.83595287
117Pseudobulbar signs (HP:0002200)1.83303045
118Shawl scrotum (HP:0000049)1.83272492
119Cutaneous finger syndactyly (HP:0010554)1.83145997
120Protrusio acetabuli (HP:0003179)1.82764038
121Calcaneovalgus deformity (HP:0001848)1.82454857
122Medulloblastoma (HP:0002885)1.80836236
123Joint laxity (HP:0001388)1.80669254
124Abnormality of the intervertebral disk (HP:0005108)1.79744869
125High anterior hairline (HP:0009890)1.79025651
126Insomnia (HP:0100785)1.79018790
127Advanced eruption of teeth (HP:0006288)1.77860981
128Turricephaly (HP:0000262)1.77785477
129Hemivertebrae (HP:0002937)1.77613119
130Short humerus (HP:0005792)1.77518823
131Intestinal fistula (HP:0100819)1.77201597
132Microglossia (HP:0000171)1.75535419
133Hypoplastic scapulae (HP:0000882)1.74245714
134Aplasia/Hypoplasia of the scapulae (HP:0006713)1.74245714
135Elfin facies (HP:0004428)1.73846450
136Skin pits (HP:0100276)1.73786584
137Distal lower limb muscle weakness (HP:0009053)1.73637397
138Broad alveolar ridges (HP:0000187)1.72679695
139Aplasia/Hypoplasia of the patella (HP:0006498)1.71875320
140Broad finger (HP:0001500)1.71330481
141Woolly hair (HP:0002224)1.70994865
142Ulnar bowing (HP:0003031)1.70742282
143Deviation of the hallux (HP:0010051)1.70309919
144Vertebral fusion (HP:0002948)1.70248675
145Cutaneous syndactyly (HP:0012725)1.69605190
146Absent eyelashes (HP:0000561)1.69420817
147Proximal placement of thumb (HP:0009623)1.68508301
148Abnormal number of incisors (HP:0011064)1.68490856
149Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.68261114
150Down-sloping shoulders (HP:0200021)1.68256515
151Supernumerary spleens (HP:0009799)1.67478575
152Wide anterior fontanel (HP:0000260)1.67163356
153Arterial tortuosity (HP:0005116)1.67129949
154Congenital diaphragmatic hernia (HP:0000776)1.67060495
155Neonatal short-limb short stature (HP:0008921)1.65431339
156Atrophic scars (HP:0001075)1.65165166
157Hallux valgus (HP:0001822)1.64706028
158Renovascular hypertension (HP:0100817)1.64215872
159Broad phalanx (HP:0006009)1.64026776
160Vascular tortuosity (HP:0004948)1.63906895
161Fragile skin (HP:0001030)1.63597129
162Abnormality of the calcaneus (HP:0008364)1.63009792
163Abnormality of the epiphysis of the femoral head (HP:0010574)1.62384209
164Buphthalmos (HP:0000557)1.62223434
165Deviation of the thumb (HP:0009603)1.61671266
166Abnormality of the upper arm (HP:0001454)1.61591067
167Genu recurvatum (HP:0002816)1.61299985
168Fragile nails (HP:0001808)1.57699178
169Aplasia/Hypoplasia of the clavicles (HP:0006710)1.56175803
170Breast carcinoma (HP:0003002)1.55748230
171Abnormality of the humerus (HP:0003063)1.55429115
172Deformed tarsal bones (HP:0008119)1.55117201
173Abnormality of femoral epiphyses (HP:0006499)1.55016725
174Abnormality involving the epiphyses of the lower limbs (HP:0006500)1.55016725
175Short clavicles (HP:0000894)1.54996299
176Sparse eyelashes (HP:0000653)1.53940798
177Long toe (HP:0010511)1.53939549
178Renal agenesis (HP:0000104)1.53133793
179Delayed cranial suture closure (HP:0000270)1.52895963
180Vaginal atresia (HP:0000148)1.50302416
181Neuroblastic tumors (HP:0004376)1.50013156
182Peripheral primitive neuroectodermal neoplasm (HP:0030067)1.50013156
183Primitive neuroectodermal tumor (HP:0030065)1.50013156

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK126.05161561
2LATS13.12953516
3VRK22.79574737
4TTK2.66576897
5EPHB22.64088847
6LATS22.60096774
7CDC72.58311532
8GRK52.37180312
9MKNK12.25091126
10SMG12.24987208
11NME22.22769134
12ERN12.19333642
13BUB12.06479217
14STK102.02023195
15MAP3K101.94110538
16GRK61.88106731
17SRPK11.85408144
18PAK41.80226076
19RET1.75660998
20EIF2AK11.73586251
21TYRO31.70975060
22STK38L1.68159104
23SCYL21.66506819
24NTRK11.63822666
25CDK71.63544304
26NEK11.63269979
27RPS6KB21.62838878
28TLK11.60190899
29MAPKAPK31.52487285
30TESK21.51919441
31TGFBR21.50958193
32ERBB31.47111007
33NME11.45430175
34PLK11.45078519
35MKNK21.42615651
36NEK21.42224415
37DDR21.39992877
38MOS1.39197467
39MST1R1.29022223
40CHEK21.28180414
41TAOK21.23709347
42CSF1R1.21312926
43EPHA21.19605286
44MUSK1.16938391
45PBK1.16474980
46STK161.14425190
47GRK11.12345200
48PDGFRA1.11845804
49MAPK71.09624614
50EEF2K1.07728903
51ADRBK21.06855703
52CHEK11.05655005
53TAF11.05517760
54AURKB1.03831816
55AURKA1.01385006
56TSSK60.99817594
57DYRK30.99736091
58FGFR10.98961532
59DYRK20.98555124
60STK30.97675004
61MAP2K20.96066866
62ILK0.95066189
63MTOR0.91166644
64ERBB20.90955312
65PASK0.90343770
66WNK10.88977451
67FGFR30.86505555
68MAP3K30.86234632
69ADRBK10.85368640
70PLK30.85241824
71MAP3K80.84430181
72TRIB30.83505468
73MATK0.81567883
74FLT30.80530282
75LIMK10.80320386
76FER0.77744003
77TGFBR10.77221304
78ICK0.74362509
79CAMK40.74043921
80FGFR40.73079861
81CDK20.72943877
82TRIM280.72924170
83AKT20.72653400
84PTK20.71879841
85SIK30.71656515
86MAP2K70.71092899
87ATR0.69815560
88CSNK1G30.68643071
89MAP3K90.68294685
90PRKCI0.67950745
91CDK80.67522341
92PAK20.66833986
93TESK10.65980942
94BRSK10.65931385
95CASK0.65717640
96HIPK20.64826147
97CSNK1A1L0.64261586
98ATM0.63712802
99RPS6KA40.61878600
100BMX0.61271267
101CDK10.59290266
102MAP2K60.57389745
103ALK0.56670317
104CSNK1E0.55979215
105PTK60.55014727
106RPS6KA20.54585032
107BCR0.54461885
108RIPK10.53844691
109TAOK10.53214496
110PAK30.52340084
111CDK180.52268957
112MELK0.52161998
113PAK10.51950484
114PDGFRB0.49938566
115DYRK1B0.49041847
116CDK60.48990277
117CDK150.48942774
118KSR10.48883362
119LRRK20.48497191
120BRD40.47193432
121CDK11A0.46875988
122MARK20.46322905
123CSNK1G10.45393742
124SIK10.44831906
125EIF2AK20.43636347
126MET0.43632588
127CDK140.41695595
128CDK40.41449139
129EPHA40.40305312
130ARAF0.39258801
131WEE10.38027433
132BRAF0.37829713
133GRK70.37811418
134CAMK2G0.37007300
135ZAK0.36630717
136CSNK1G20.36484945
137PLK40.35805204
138FGFR20.35130561
139RPS6KL10.35102304
140RPS6KC10.35102304
141VRK10.35096861
142MAP3K60.35093659
143TTN0.34290132
144PKN20.34053390
145PIM20.33465178
146STK40.31904558

Predicted pathways (KEGG)

RankGene SetZ-score
1Basal cell carcinoma_Homo sapiens_hsa052173.23979621
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.90540385
3Cell cycle_Homo sapiens_hsa041102.72825371
4Spliceosome_Homo sapiens_hsa030402.72348187
5RNA transport_Homo sapiens_hsa030132.71023220
6Hippo signaling pathway_Homo sapiens_hsa043902.56664004
7mRNA surveillance pathway_Homo sapiens_hsa030152.43826800
8Hedgehog signaling pathway_Homo sapiens_hsa043402.42462112
9Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045502.39191199
10DNA replication_Homo sapiens_hsa030302.35969156
11Mismatch repair_Homo sapiens_hsa034302.01631381
12MicroRNAs in cancer_Homo sapiens_hsa052062.00570902
13Thyroid cancer_Homo sapiens_hsa052161.90050364
14Ribosome_Homo sapiens_hsa030101.85870902
15Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.78119527
16Adherens junction_Homo sapiens_hsa045201.77025160
17RNA degradation_Homo sapiens_hsa030181.67102921
18Vibrio cholerae infection_Homo sapiens_hsa051101.66220854
19Base excision repair_Homo sapiens_hsa034101.65390230
20Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.64661357
21p53 signaling pathway_Homo sapiens_hsa041151.62963662
22Notch signaling pathway_Homo sapiens_hsa043301.62877420
23Biosynthesis of amino acids_Homo sapiens_hsa012301.61145006
24Bladder cancer_Homo sapiens_hsa052191.59809852
25Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.57044197
26TGF-beta signaling pathway_Homo sapiens_hsa043501.57037861
27Wnt signaling pathway_Homo sapiens_hsa043101.54570570
28Proteoglycans in cancer_Homo sapiens_hsa052051.50009866
29Nucleotide excision repair_Homo sapiens_hsa034201.46764279
30Fanconi anemia pathway_Homo sapiens_hsa034601.45567925
31Pentose phosphate pathway_Homo sapiens_hsa000301.42768535
32Steroid biosynthesis_Homo sapiens_hsa001001.42254008
33One carbon pool by folate_Homo sapiens_hsa006701.41433258
34Homologous recombination_Homo sapiens_hsa034401.32350765
35RNA polymerase_Homo sapiens_hsa030201.27639070
36Pathways in cancer_Homo sapiens_hsa052001.27408426
37Tight junction_Homo sapiens_hsa045301.27185112
38Transcriptional misregulation in cancer_Homo sapiens_hsa052021.25200659
39HTLV-I infection_Homo sapiens_hsa051661.25105360
402-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.24681639
41Basal transcription factors_Homo sapiens_hsa030221.23081722
42Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.22384163
43Arachidonic acid metabolism_Homo sapiens_hsa005901.20804128
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.19972152
45Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19895441
46Colorectal cancer_Homo sapiens_hsa052101.15597182
47N-Glycan biosynthesis_Homo sapiens_hsa005101.12596050
48Systemic lupus erythematosus_Homo sapiens_hsa053221.12182780
49Chronic myeloid leukemia_Homo sapiens_hsa052201.11967178
50Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.11857178
51Fatty acid elongation_Homo sapiens_hsa000621.08992736
52Axon guidance_Homo sapiens_hsa043601.06476384
53Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.06293894
54Small cell lung cancer_Homo sapiens_hsa052221.06231801
55mTOR signaling pathway_Homo sapiens_hsa041501.05519591
56Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05458050
57Oocyte meiosis_Homo sapiens_hsa041141.04844730
58Carbon metabolism_Homo sapiens_hsa012001.04304155
59Central carbon metabolism in cancer_Homo sapiens_hsa052301.03726161
60Endometrial cancer_Homo sapiens_hsa052131.02365817
61Galactose metabolism_Homo sapiens_hsa000520.98639575
62Viral carcinogenesis_Homo sapiens_hsa052030.97007996
63Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.95982082
64Glycosaminoglycan degradation_Homo sapiens_hsa005310.93037412
65Vitamin B6 metabolism_Homo sapiens_hsa007500.92167804
66Chemical carcinogenesis_Homo sapiens_hsa052040.91886478
67ECM-receptor interaction_Homo sapiens_hsa045120.89895932
68Melanoma_Homo sapiens_hsa052180.89245021
69Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88963040
70Proteasome_Homo sapiens_hsa030500.86804747
71Pancreatic cancer_Homo sapiens_hsa052120.86641208
72Non-small cell lung cancer_Homo sapiens_hsa052230.85183625
73Melanogenesis_Homo sapiens_hsa049160.84331772
74Fructose and mannose metabolism_Homo sapiens_hsa000510.84101446
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83496600
76Prostate cancer_Homo sapiens_hsa052150.83213835
77Pentose and glucuronate interconversions_Homo sapiens_hsa000400.81416902
78Cyanoamino acid metabolism_Homo sapiens_hsa004600.80884484
79Linoleic acid metabolism_Homo sapiens_hsa005910.80017112
80ErbB signaling pathway_Homo sapiens_hsa040120.77112779
81Thyroid hormone signaling pathway_Homo sapiens_hsa049190.76730141
82Focal adhesion_Homo sapiens_hsa045100.75876290
83Rap1 signaling pathway_Homo sapiens_hsa040150.75513857
84AMPK signaling pathway_Homo sapiens_hsa041520.72057797
85Sulfur relay system_Homo sapiens_hsa041220.71832629
86PI3K-Akt signaling pathway_Homo sapiens_hsa041510.71619656
87Regulation of actin cytoskeleton_Homo sapiens_hsa048100.71110150
88Insulin signaling pathway_Homo sapiens_hsa049100.70877757
89Other glycan degradation_Homo sapiens_hsa005110.70004520
90Pyrimidine metabolism_Homo sapiens_hsa002400.69235585
91alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.67444043
92Oxidative phosphorylation_Homo sapiens_hsa001900.66846993
93Alcoholism_Homo sapiens_hsa050340.65495432
94Huntingtons disease_Homo sapiens_hsa050160.64998059
95Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.61945828
96Lysosome_Homo sapiens_hsa041420.60546720
97VEGF signaling pathway_Homo sapiens_hsa043700.60174724
98Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.58188792
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.56957728
100Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.56922710
101Glutathione metabolism_Homo sapiens_hsa004800.56701519
102Herpes simplex infection_Homo sapiens_hsa051680.55614307
103Epstein-Barr virus infection_Homo sapiens_hsa051690.54956939
104Retinol metabolism_Homo sapiens_hsa008300.54202275
105Sphingolipid metabolism_Homo sapiens_hsa006000.53686721
106Pyruvate metabolism_Homo sapiens_hsa006200.52058242
107Parkinsons disease_Homo sapiens_hsa050120.51617833
108Acute myeloid leukemia_Homo sapiens_hsa052210.50754883
109Dilated cardiomyopathy_Homo sapiens_hsa054140.50493731
110Neurotrophin signaling pathway_Homo sapiens_hsa047220.49150210
111Non-homologous end-joining_Homo sapiens_hsa034500.48886205
112Apoptosis_Homo sapiens_hsa042100.46532108
113Renal cell carcinoma_Homo sapiens_hsa052110.45644102
114Sulfur metabolism_Homo sapiens_hsa009200.45280731
115Cysteine and methionine metabolism_Homo sapiens_hsa002700.45230485
116Estrogen signaling pathway_Homo sapiens_hsa049150.44521905
117Glioma_Homo sapiens_hsa052140.43970671
118Viral myocarditis_Homo sapiens_hsa054160.43436760
119Leukocyte transendothelial migration_Homo sapiens_hsa046700.43004681
120Cardiac muscle contraction_Homo sapiens_hsa042600.42706692
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42215333
122Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.42039510
123Ovarian steroidogenesis_Homo sapiens_hsa049130.40343232
124Prolactin signaling pathway_Homo sapiens_hsa049170.38481260
125Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.36619581
126Ras signaling pathway_Homo sapiens_hsa040140.35189471
127Lysine degradation_Homo sapiens_hsa003100.35019587
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.33403494
129Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.32368107
130Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.32088259
131Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32074939
132Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.30248283

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