CRACR2A

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)7.04067688
2antigen processing and presentation of endogenous peptide antigen (GO:0002483)5.94866470
3antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)5.94866470
4regulation of gamma-delta T cell differentiation (GO:0045586)5.93971179
5positive thymic T cell selection (GO:0045059)5.66962890
6negative T cell selection (GO:0043383)5.66449638
7negative thymic T cell selection (GO:0045060)5.56984955
8leukocyte aggregation (GO:0070486)5.41510230
9regulation of gamma-delta T cell activation (GO:0046643)5.38059915
10negative regulation of leukocyte mediated cytotoxicity (GO:0001911)5.28967289
11negative regulation of cell killing (GO:0031342)5.28967289
12antigen processing and presentation of endogenous antigen (GO:0019883)5.03733761
13antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.03149307
14interferon-gamma production (GO:0032609)5.02048909
15thymic T cell selection (GO:0045061)4.94450468
16positive T cell selection (GO:0043368)4.90802656
17response to interleukin-15 (GO:0070672)4.82131721
18positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)4.80000778
19cellular response to interleukin-15 (GO:0071350)4.66260545
20T cell migration (GO:0072678)4.61569129
21T cell selection (GO:0045058)4.56892980
22regulation of B cell receptor signaling pathway (GO:0050855)4.55044196
23regulation of interleukin-12 biosynthetic process (GO:0045075)3.94305515
24regulation of B cell differentiation (GO:0045577)3.93730728
25positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.92612733
26T cell receptor signaling pathway (GO:0050852)3.85510522
27regulation of isotype switching to IgG isotypes (GO:0048302)3.83238849
28cilium or flagellum-dependent cell motility (GO:0001539)3.77553806
29positive regulation of B cell differentiation (GO:0045579)3.76490490
30antigen receptor-mediated signaling pathway (GO:0050851)3.65437852
31Arp2/3 complex-mediated actin nucleation (GO:0034314)3.61934093
32L-fucose catabolic process (GO:0042355)3.61620876
33fucose catabolic process (GO:0019317)3.61620876
34L-fucose metabolic process (GO:0042354)3.61620876
35defense response to fungus (GO:0050832)3.60185594
36regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.58750710
37regulation of alpha-beta T cell proliferation (GO:0046640)3.58356965
38regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.57631611
39regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.55831999
40T cell costimulation (GO:0031295)3.55228178
41mast cell activation (GO:0045576)3.54865452
42antigen processing and presentation via MHC class Ib (GO:0002475)3.54157251
43lymphocyte costimulation (GO:0031294)3.49584496
44T cell homeostasis (GO:0043029)3.48531964
45B cell receptor signaling pathway (GO:0050853)3.46245636
46positive regulation of isotype switching (GO:0045830)3.43023455
47leukocyte cell-cell adhesion (GO:0007159)3.42922339
48regulation of T cell receptor signaling pathway (GO:0050856)3.40439973
49negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.38626870
50positive regulation of defense response to virus by host (GO:0002230)3.37380869
51regulation of T cell tolerance induction (GO:0002664)3.30995771
52positive regulation of interleukin-2 production (GO:0032743)3.29381913
53positive regulation of alpha-beta T cell proliferation (GO:0046641)3.27300698
54regulation of natural killer cell mediated immunity (GO:0002715)3.26481788
55regulation of natural killer cell mediated cytotoxicity (GO:0042269)3.26481788
56positive regulation of tolerance induction (GO:0002645)3.26036941
57cellular response to zinc ion (GO:0071294)3.24321557
58protein K11-linked deubiquitination (GO:0035871)3.23544202
59mature B cell differentiation (GO:0002335)3.22117998
60alpha-beta T cell differentiation (GO:0046632)3.21166020
61DNA deamination (GO:0045006)3.17686148
62negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.16364019
63regulation of response to interferon-gamma (GO:0060330)3.12795595
64regulation of interleukin-6 biosynthetic process (GO:0045408)3.12315949
65regulation of interleukin-2 biosynthetic process (GO:0045076)3.11853827
66mast cell degranulation (GO:0043303)3.11444397
67mast cell activation involved in immune response (GO:0002279)3.11444397
68megakaryocyte development (GO:0035855)3.09836616
69regulation of interferon-gamma-mediated signaling pathway (GO:0060334)3.07293230
70NIK/NF-kappaB signaling (GO:0038061)3.06096962
71indolalkylamine metabolic process (GO:0006586)3.05523417
72regulation of regulatory T cell differentiation (GO:0045589)3.05451174
73regulation of cytokine production involved in inflammatory response (GO:1900015)3.04731192
74negative regulation of T cell mediated immunity (GO:0002710)3.03215442
75hepatocyte apoptotic process (GO:0097284)2.99629668
76positive regulation of natural killer cell mediated immunity (GO:0002717)2.99186660
77positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.99186660
78actin nucleation (GO:0045010)2.98672511
79positive regulation of DNA recombination (GO:0045911)2.98667953
80indole-containing compound catabolic process (GO:0042436)2.96620656
81indolalkylamine catabolic process (GO:0046218)2.96620656
82tryptophan catabolic process (GO:0006569)2.96620656
83activated T cell proliferation (GO:0050798)2.96615558
84regulation of memory T cell differentiation (GO:0043380)2.96473516
85Peyers patch development (GO:0048541)2.96288119
86mucosal-associated lymphoid tissue development (GO:0048537)2.96288119
87lymphocyte homeostasis (GO:0002260)2.95087699
88protein K48-linked deubiquitination (GO:0071108)2.93535531
89positive regulation of granulocyte differentiation (GO:0030854)2.92869809
90mature B cell differentiation involved in immune response (GO:0002313)2.91926767
91negative regulation of phagocytosis (GO:0050765)2.91735541
92regulation of T cell mediated cytotoxicity (GO:0001914)2.91079041
93tryptophan metabolic process (GO:0006568)2.90421139
94natural killer cell activation (GO:0030101)2.90072460
95myeloid dendritic cell activation (GO:0001773)2.89194950
96response to fungus (GO:0009620)2.87727929
97rRNA catabolic process (GO:0016075)2.87110579
98negative regulation of T cell receptor signaling pathway (GO:0050860)2.86829378
99ribosomal small subunit assembly (GO:0000028)2.86149604
100natural killer cell differentiation (GO:0001779)2.85343182
101positive regulation of T cell mediated cytotoxicity (GO:0001916)2.84456938
102positive regulation of B cell mediated immunity (GO:0002714)2.84177258
103positive regulation of immunoglobulin mediated immune response (GO:0002891)2.84177258
104regulation of isotype switching (GO:0045191)2.83768526
105negative regulation of erythrocyte differentiation (GO:0045647)2.83191196
106leukocyte degranulation (GO:0043299)2.82306065
107negative regulation of adaptive immune response based on somatic recombination of immune receptors b2.81731656
108cellular extravasation (GO:0045123)2.81526429
109regulation of thymocyte apoptotic process (GO:0070243)2.81378466
110tolerance induction (GO:0002507)2.81358364
111T cell differentiation (GO:0030217)2.81324395
112T cell differentiation involved in immune response (GO:0002292)2.80552881
113alpha-beta T cell differentiation involved in immune response (GO:0002293)2.80552881
114alpha-beta T cell activation involved in immune response (GO:0002287)2.80552881
115regulation of germinal center formation (GO:0002634)2.79927393
116negative regulation of lymphocyte mediated immunity (GO:0002707)2.78124351
117regulation of tolerance induction (GO:0002643)2.75927306
118alpha-beta T cell activation (GO:0046631)2.75866064
119protein K63-linked deubiquitination (GO:0070536)2.75331516
120immune response-activating cell surface receptor signaling pathway (GO:0002429)2.74189381
121regulation of type I interferon-mediated signaling pathway (GO:0060338)2.73980352
122negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.71789774
123negative regulation of T-helper cell differentiation (GO:0045623)2.71789774
124cytidine metabolic process (GO:0046087)2.70234204
125cytidine catabolic process (GO:0006216)2.70234204
126cytidine deamination (GO:0009972)2.70234204
127CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)2.69737606
128T-helper cell differentiation (GO:0042093)2.69737606
129negative regulation of thymocyte apoptotic process (GO:0070244)2.69119097
130epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.68453048
131negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.67770795
132positive regulation of macrophage differentiation (GO:0045651)2.67598592
133negative regulation of interleukin-12 production (GO:0032695)2.67534538
134cytokine biosynthetic process (GO:0042089)2.66112474
135leukocyte homeostasis (GO:0001776)2.65439282
136regulation of leukocyte mediated cytotoxicity (GO:0001910)2.64108819
137pyrimidine ribonucleoside catabolic process (GO:0046133)2.64090698
138negative regulation of adaptive immune response (GO:0002820)2.63750397
139regulation of defense response to virus by host (GO:0050691)2.63578698
140organelle membrane fusion (GO:0090174)2.63308400
141regulation of B cell mediated immunity (GO:0002712)2.62164094
142cellular response to ethanol (GO:0071361)2.62039459
143T cell proliferation (GO:0042098)2.61889430
144T cell activation (GO:0042110)2.61286237
145regulation of immunoglobulin mediated immune response (GO:0002889)2.60522102
146response to protozoan (GO:0001562)2.60227803
147signal peptide processing (GO:0006465)2.59763590
148CD4-positive, alpha-beta T cell differentiation (GO:0043367)2.59284861
149establishment of protein localization to Golgi (GO:0072600)2.57378283
150kynurenine metabolic process (GO:0070189)2.56509664
151histone H3-K4 trimethylation (GO:0080182)2.54719143
152defense response to protozoan (GO:0042832)2.53506012
153piRNA metabolic process (GO:0034587)2.52311874
154neutrophil activation (GO:0042119)2.51004886
155neutrophil activation involved in immune response (GO:0002283)2.46974441
156purinergic nucleotide receptor signaling pathway (GO:0035590)2.45987548
157regulation of granulocyte differentiation (GO:0030852)2.45784373

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1STAT6_20620947_ChIP-Seq_CD4_POS_T_Human5.00265591
2E2F7_22180533_ChIP-Seq_HELA_Human4.81339820
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.77689604
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.62270329
5MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.50144543
6MYC_22102868_ChIP-Seq_BL_Human3.42303517
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.03991446
8VDR_21846776_ChIP-Seq_THP-1_Human2.97762826
9FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.85390052
10SCL_19346495_ChIP-Seq_HPC-7_Human2.80408154
11STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.78769380
12STAT4_19710469_ChIP-ChIP_TH1__Mouse2.74925376
13RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.72489537
14MYB_26560356_Chip-Seq_TH2_Human2.69267993
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.66884784
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.66238122
17ZNF274_21170338_ChIP-Seq_K562_Hela2.64924809
18SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.63759268
19RUNX_20019798_ChIP-Seq_JUKART_Human2.61510590
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.51556719
21UTX_26944678_Chip-Seq_JUKART_Human2.49020203
22MAF_26560356_Chip-Seq_TH1_Human2.47328526
23MYB_26560356_Chip-Seq_TH1_Human2.47143773
24SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.45179995
25BP1_19119308_ChIP-ChIP_Hs578T_Human2.39860294
26IRF8_21731497_ChIP-ChIP_J774_Mouse2.38204181
27VDR_22108803_ChIP-Seq_LS180_Human2.36252001
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.32282284
29RUNX1_22412390_ChIP-Seq_EML_Mouse2.29914011
30SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.29588104
31VDR_24763502_ChIP-Seq_THP-1_Human2.22541721
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.17826808
33SPI1_23547873_ChIP-Seq_NB4_Human2.14415753
34NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.11752124
35IRF8_27001747_Chip-Seq_BMDM_Mouse2.06320335
36TCF7_22412390_ChIP-Seq_EML_Mouse2.04435765
37ER_23166858_ChIP-Seq_MCF-7_Human2.00577752
38E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.97624691
39FOXM1_23109430_ChIP-Seq_U2OS_Human1.97080852
40BRD4_27068464_Chip-Seq_AML-cells_Mouse1.96501621
41FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.94630388
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.82507169
43NOTCH1_21737748_ChIP-Seq_TLL_Human1.82478633
44EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.80867116
45SPI1_23127762_ChIP-Seq_K562_Human1.80807117
46GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.78428331
47PCGF2_27294783_Chip-Seq_ESCs_Mouse1.77922060
48IGF1R_20145208_ChIP-Seq_DFB_Human1.75595577
49ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.74943831
50NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.71360586
51GATA3_27048872_Chip-Seq_THYMUS_Human1.69513355
52KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.67676046
53CIITA_25753668_ChIP-Seq_RAJI_Human1.67207708
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.67099287
55KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.65915177
56ELF1_17652178_ChIP-ChIP_JURKAT_Human1.65542546
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.65131094
58MAF_26560356_Chip-Seq_TH2_Human1.63363704
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.60450765
60GATA2_22383799_ChIP-Seq_G1ME_Mouse1.54657862
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.54645085
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.49504418
63KDM2B_26808549_Chip-Seq_DND41_Human1.46922646
64GATA1_22025678_ChIP-Seq_K562_Human1.45931444
65TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.44960636
66POU3F2_20337985_ChIP-ChIP_501MEL_Human1.41220062
67SMAD_19615063_ChIP-ChIP_OVARY_Human1.40112265
68FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.40016492
69VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.39816968
70RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.39424174
71VDR_24787735_ChIP-Seq_THP-1_Human1.39355415
72PRDM14_20953172_ChIP-Seq_ESCs_Human1.38969780
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.36689287
74SALL1_21062744_ChIP-ChIP_HESCs_Human1.34086585
75GBX2_23144817_ChIP-Seq_PC3_Human1.33307946
76HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.32339258
77EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.31696721
78ERG_20887958_ChIP-Seq_HPC-7_Mouse1.31544896
79EGR1_23403033_ChIP-Seq_LIVER_Mouse1.31539004
80GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29297861
81BCAT_22108803_ChIP-Seq_LS180_Human1.29063549
82GATA1_19941827_ChIP-Seq_MEL_Mouse1.29054135
83PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.28353611
84GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.27504300
85STAT3_23295773_ChIP-Seq_U87_Human1.26483530
86E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26129104
87NFE2_27457419_Chip-Seq_LIVER_Mouse1.26067351
88CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.24353864
89ELK3_25401928_ChIP-Seq_HUVEC_Human1.23798368
90SMRT_27268052_Chip-Seq_Bcells_Human1.23429005
91SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23095976
92IRF1_19129219_ChIP-ChIP_H3396_Human1.22528426
93TP53_22573176_ChIP-Seq_HFKS_Human1.21929414
94STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.21531360
95EWS_26573619_Chip-Seq_HEK293_Human1.21477099
96ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20703155
97TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human1.20347376
98RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.20291575
99PCGF2_27294783_Chip-Seq_NPCs_Mouse1.19574331
100FOXP3_21729870_ChIP-Seq_TREG_Human1.18950455
101CTBP1_25329375_ChIP-Seq_LNCAP_Human1.18792979
102HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18222536
103CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.18101140
104SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.17962755
105KDM2B_26808549_Chip-Seq_SUP-B15_Human1.16976263
106PU_27001747_Chip-Seq_BMDM_Mouse1.15963932
107CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.13992948
108FOXA1_25329375_ChIP-Seq_VCAP_Human1.13961670
109FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13961670
110EZH2_27294783_Chip-Seq_NPCs_Mouse1.13643367
111BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.12988935
112RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.11966195
113CTBP2_25329375_ChIP-Seq_LNCAP_Human1.11177890
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.11021583
115FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10798628
116MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.10557174
117GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.10246733
118TCF4_23295773_ChIP-Seq_U87_Human1.09378505
119CBP_20019798_ChIP-Seq_JUKART_Human1.09069027
120IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.09069027
121CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.08751663
122CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.07424783
123VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.04773326
124PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.04513749
125PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.04114906
126UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03406595
127GATA3_21878914_ChIP-Seq_MCF-7_Human1.03084889
128VDR_23849224_ChIP-Seq_CD4+_Human1.02858367
129AR_21572438_ChIP-Seq_LNCaP_Human1.02518534
130GATA3_26560356_Chip-Seq_TH2_Human1.02439998
131AR_20517297_ChIP-Seq_VCAP_Human1.01490080
132FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.00922509
133GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.99361843
134PU.1_20513432_ChIP-Seq_Bcells_Mouse0.97976512
135P300_19829295_ChIP-Seq_ESCs_Human0.97774708
136GATA3_26560356_Chip-Seq_TH1_Human0.96554996
137NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96183191
138CRX_20693478_ChIP-Seq_RETINA_Mouse0.94883059
139NCOR_22424771_ChIP-Seq_293T_Human0.94704114
140FUS_26573619_Chip-Seq_HEK293_Human0.94552846
141TCF12/HEB_22897851_ChIP-Seq_JUKARTE6-1_Human0.94465133
142RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.94451406
143FLI1_21867929_ChIP-Seq_TH2_Mouse0.92655242
144CDX2_22108803_ChIP-Seq_LS180_Human0.92462220
145OCT4_21477851_ChIP-Seq_ESCs_Mouse0.91844363
146NCOR1_26117541_ChIP-Seq_K562_Human0.90621881
147PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.90585094
148E2F1_21310950_ChIP-Seq_MCF-7_Human0.89761144
149CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.89569051
150GATA2_19941826_ChIP-Seq_K562_Human0.88767785
151Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.88401014
152CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.88145124
153RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87071518
154GATA1_19941826_ChIP-Seq_K562_Human0.83144543
155NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.82565123
156STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.80837335
157FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80766424
158SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.80040206
159TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.79741666
160SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79602620
161TFEB_21752829_ChIP-Seq_HELA_Human0.79017262
162KDM2B_26808549_Chip-Seq_JURKAT_Human0.78329855
163GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.75772912
164ETS1_22383799_ChIP-Seq_G1ME_Mouse0.75313563
165BCL6_27268052_Chip-Seq_Bcells_Human0.72321502

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005671_abnormal_response_to3.88442722
2MP0003763_abnormal_thymus_physiology3.85975577
3MP0001835_abnormal_antigen_presentation3.13705762
4MP0001873_stomach_inflammation3.01345281
5MP0002396_abnormal_hematopoietic_system3.00454231
6MP0001800_abnormal_humoral_immune2.94949784
7MP0000685_abnormal_immune_system2.87932381
8MP0009785_altered_susceptibility_to2.77329831
9MP0002420_abnormal_adaptive_immunity2.63366435
10MP0001819_abnormal_immune_cell2.59859190
11MP0003436_decreased_susceptibility_to2.57203733
12MP0002398_abnormal_bone_marrow2.55856350
13MP0003866_abnormal_defecation2.55362066
14MP0002723_abnormal_immune_serum2.55269089
15MP0002452_abnormal_antigen_presenting2.53689079
16MP0001790_abnormal_immune_system2.47735812
17MP0005387_immune_system_phenotype2.47735812
18MP0005025_abnormal_response_to2.47568781
19MP0005000_abnormal_immune_tolerance2.47482809
20MP0009333_abnormal_splenocyte_physiolog2.46212008
21MP0002405_respiratory_system_inflammati2.38485569
22MP0003300_gastrointestinal_ulcer2.33509613
23MP0002166_altered_tumor_susceptibility2.30496722
24MP0010155_abnormal_intestine_physiology2.30429036
25MP0005174_abnormal_tail_pigmentation2.28777435
26MP0004808_abnormal_hematopoietic_stem2.25703907
27MP0000716_abnormal_immune_system2.25094268
28MP0005464_abnormal_platelet_physiology2.22717807
29MP0002419_abnormal_innate_immunity2.18023281
30MP0002722_abnormal_immune_system2.14146383
31MP0000703_abnormal_thymus_morphology2.11658952
32MP0000689_abnormal_spleen_morphology2.08367252
33MP0003724_increased_susceptibility_to2.07014329
34MP0003303_peritoneal_inflammation2.03975927
35MP0000490_abnormal_crypts_of2.00695052
36MP0002148_abnormal_hypersensitivity_rea1.95250355
37MP0004947_skin_inflammation1.94064196
38MP0002429_abnormal_blood_cell1.90501648
39MP0009278_abnormal_bone_marrow1.85958423
40MP0006082_CNS_inflammation1.79372504
41MP0000569_abnormal_digit_pigmentation1.76929064
42MP0005397_hematopoietic_system_phenotyp1.75141379
43MP0001545_abnormal_hematopoietic_system1.75141379
44MP0001845_abnormal_inflammatory_respons1.73095557
45MP0002006_tumorigenesis1.71816071
46MP0002138_abnormal_hepatobiliary_system1.63843947
47MP0004147_increased_porphyrin_level1.57277396
48MP0008877_abnormal_DNA_methylation1.55374873
49MP0003252_abnormal_bile_duct1.54875040
50MP0008872_abnormal_physiological_respon1.48684555
51MP0000465_gastrointestinal_hemorrhage1.48339655
52MP0003693_abnormal_embryo_hatching1.45489328
53MP0001853_heart_inflammation1.44769592
54MP0004510_myositis1.44027210
55MP0008875_abnormal_xenobiotic_pharmacok1.41507404
56MP0002009_preneoplasia1.38870101
57MP0002928_abnormal_bile_duct1.37498966
58MP0002933_joint_inflammation1.35261644
59MP0000858_altered_metastatic_potential1.34402501
60MP0005075_abnormal_melanosome_morpholog1.31412596
61MP0003195_calcinosis1.31179113
62MP0003646_muscle_fatigue1.31163800
63MP0001501_abnormal_sleep_pattern1.30940062
64MP0004043_abnormal_pH_regulation1.28375791
65MP0000015_abnormal_ear_pigmentation1.27289766
66MP0000427_abnormal_hair_cycle1.22553556
67MP0003183_abnormal_peptide_metabolism1.20039931
68MP0005084_abnormal_gallbladder_morpholo1.18427908
69MP0008469_abnormal_protein_level1.16688356
70MP0003172_abnormal_lysosome_physiology1.15987876
71MP0002019_abnormal_tumor_incidence1.15700715
72MP0005076_abnormal_cell_differentiation1.15511884
73MP0008057_abnormal_DNA_replication1.14014391
74MP0001533_abnormal_skeleton_physiology1.13743003
75MP0003448_altered_tumor_morphology1.12510706
76MP0003077_abnormal_cell_cycle1.11159172
77MP0005551_abnormal_eye_electrophysiolog1.08351332
78MP0001663_abnormal_digestive_system1.06949999
79MP0001765_abnormal_ion_homeostasis1.04518432
80MP0010352_gastrointestinal_tract_polyps1.04116320
81MP0002095_abnormal_skin_pigmentation1.00430392
82MP0010307_abnormal_tumor_latency1.00001409
83MP0005310_abnormal_salivary_gland0.99746679
84MP0002132_abnormal_respiratory_system0.97852065
85MP0003828_pulmonary_edema0.97459297
86MP0003787_abnormal_imprinting0.95476136
87MP0005058_abnormal_lysosome_morphology0.95133883
88MP0003045_fibrosis0.94272940
89MP0001666_abnormal_nutrient_absorption0.93707408
90MP0000477_abnormal_intestine_morphology0.93056457
91MP0002876_abnormal_thyroid_physiology0.91704610
92MP0010094_abnormal_chromosome_stability0.91479022
93MP0004957_abnormal_blastocyst_morpholog0.88106354
94MP0002693_abnormal_pancreas_physiology0.87869296
95MP0008995_early_reproductive_senescence0.86201534
96MP0009764_decreased_sensitivity_to0.84152116
97MP0005023_abnormal_wound_healing0.82400793
98MP0000372_irregular_coat_pigmentation0.82150268
99MP0003566_abnormal_cell_adhesion0.81742450
100MP0001851_eye_inflammation0.81587305
101MP0005389_reproductive_system_phenotype0.81154451
102MP0001919_abnormal_reproductive_system0.80960668
103MP0001764_abnormal_homeostasis0.79405118
104MP0005645_abnormal_hypothalamus_physiol0.79222934
105MP0009765_abnormal_xenobiotic_induced0.78360992
106MP0003191_abnormal_cellular_cholesterol0.77971131
107MP0005166_decreased_susceptibility_to0.77273196
108MP0002998_abnormal_bone_remodeling0.77238089
109MP0002136_abnormal_kidney_physiology0.74928707
110MP0003111_abnormal_nucleus_morphology0.74104776
111MP0001986_abnormal_taste_sensitivity0.74064477
112MP0002102_abnormal_ear_morphology0.70941264
113MP0008058_abnormal_DNA_repair0.70469247
114MP0000230_abnormal_systemic_arterial0.69466862
115MP0000470_abnormal_stomach_morphology0.68379715
116MP0009763_increased_sensitivity_to0.68238040
117MP0002168_other_aberrant_phenotype0.67309465
118MP0009840_abnormal_foam_cell0.66930175
119MP0001968_abnormal_touch/_nociception0.66918415
120MP0004484_altered_response_of0.66901910
121MP0005085_abnormal_gallbladder_physiolo0.66474023
122MP0003656_abnormal_erythrocyte_physiolo0.65288278
123MP0005381_digestive/alimentary_phenotyp0.65271857
124MP0008873_increased_physiological_sensi0.64692156
125MP0004264_abnormal_extraembryonic_tissu0.64295431
126MP0000343_altered_response_to0.63792142
127MP0000313_abnormal_cell_death0.61642451
128MP0003943_abnormal_hepatobiliary_system0.61379237
129MP0000371_diluted_coat_color0.59751835
130MP0008961_abnormal_basal_metabolism0.59118479
131MP0004381_abnormal_hair_follicle0.56245727
132MP0002277_abnormal_respiratory_mucosa0.54602968
133MP0003091_abnormal_cell_migration0.53465558
134MP0000609_abnormal_liver_physiology0.51965213
135MP0003795_abnormal_bone_structure0.50990126
136MP0001243_abnormal_dermal_layer0.48506477

Predicted human phenotypes

RankGene SetZ-score
1IgM deficiency (HP:0002850)5.32398296
2T lymphocytopenia (HP:0005403)5.21683899
3Abnormality of T cell number (HP:0011839)4.85920501
4Recurrent fungal infections (HP:0002841)4.80898685
5Eczematoid dermatitis (HP:0000976)4.45478628
6Abnormality of the fingertips (HP:0001211)4.27690271
7Recurrent viral infections (HP:0004429)4.25880317
8Recurrent abscess formation (HP:0002722)4.25269776
9Abnormality of T cells (HP:0002843)4.18573787
10Elevated erythrocyte sedimentation rate (HP:0003565)4.17089547
11Severe combined immunodeficiency (HP:0004430)3.93312224
12Gastrointestinal inflammation (HP:0004386)3.87767673
13Panhypogammaglobulinemia (HP:0003139)3.86349159
14Inflammation of the large intestine (HP:0002037)3.84536866
15Recurrent bronchitis (HP:0002837)3.83567739
16Abnormal delayed hypersensitivity skin test (HP:0002963)3.82684139
17Thrombocytosis (HP:0001894)3.77875594
18Thyroiditis (HP:0100646)3.75267921
19Chronic otitis media (HP:0000389)3.74402191
20Recurrent cutaneous fungal infections (HP:0011370)3.71434398
21Chronic mucocutaneous candidiasis (HP:0002728)3.71434398
22Chronic diarrhea (HP:0002028)3.67614399
23Combined immunodeficiency (HP:0005387)3.64549752
24Pustule (HP:0200039)3.60581925
25Nasal polyposis (HP:0100582)3.56244295
26Stomatitis (HP:0010280)3.50315888
27Congenital stationary night blindness (HP:0007642)3.37136048
28Myositis (HP:0100614)3.34350831
29Stomach cancer (HP:0012126)3.33841221
30Abnormality of eosinophils (HP:0001879)3.31305197
31Pancreatic cysts (HP:0001737)3.29921049
32Abnormality of the nasal mucosa (HP:0000433)3.28287435
33Autoimmune thrombocytopenia (HP:0001973)3.28032485
34IgG deficiency (HP:0004315)3.26891442
35Abnormality of T cell physiology (HP:0011840)3.25491192
36Meningitis (HP:0001287)3.22718924
37Recurrent bacterial skin infections (HP:0005406)3.21532075
38Spontaneous hematomas (HP:0007420)3.21475805
39Abnormality of B cell number (HP:0010975)3.20374653
40B lymphocytopenia (HP:0010976)3.20374653
41Prolonged bleeding time (HP:0003010)3.06188359
42Abnormality of the renal cortex (HP:0011035)3.00643975
43Increased IgE level (HP:0003212)2.99878628
44Agammaglobulinemia (HP:0004432)2.97039679
45Recurrent skin infections (HP:0001581)2.97030910
46Lymphopenia (HP:0001888)2.96892477
47Colitis (HP:0002583)2.95867129
48Eosinophilia (HP:0001880)2.85698712
49Attenuation of retinal blood vessels (HP:0007843)2.85486956
50Leukocytosis (HP:0001974)2.83571248
51Mediastinal lymphadenopathy (HP:0100721)2.82369105
52Abnormality of cells of the lymphoid lineage (HP:0012140)2.81888838
53Pancreatic fibrosis (HP:0100732)2.79867974
54Hypoplasia of the thymus (HP:0000778)2.79525827
55Interstitial pulmonary disease (HP:0006530)2.76511999
56Obstructive lung disease (HP:0006536)2.75578597
57Chronic obstructive pulmonary disease (HP:0006510)2.75578597
58Keratoconjunctivitis (HP:0001096)2.73019038
59Cheilitis (HP:0100825)2.71760463
60Periodontitis (HP:0000704)2.64537373
61Cellulitis (HP:0100658)2.64338185
62Vasculitis (HP:0002633)2.63831519
63Keratoconjunctivitis sicca (HP:0001097)2.63068653
64Absent rod-and cone-mediated responses on ERG (HP:0007688)2.62789890
65Petechiae (HP:0000967)2.61114674
66Epistaxis (HP:0000421)2.59355105
67Abnormality of midbrain morphology (HP:0002418)2.57523036
68Molar tooth sign on MRI (HP:0002419)2.57523036
69Abnormal platelet volume (HP:0011876)2.52498550
70Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.48597468
71Granulocytopenia (HP:0001913)2.47060142
72Abnormal respiratory motile cilium morphology (HP:0005938)2.46662151
73Abnormal respiratory epithelium morphology (HP:0012253)2.46662151
74IgA deficiency (HP:0002720)2.46357779
75Absent/shortened dynein arms (HP:0200106)2.42847647
76Dynein arm defect of respiratory motile cilia (HP:0012255)2.42847647
77Clumsiness (HP:0002312)2.41462315
78Abnormal rod and cone electroretinograms (HP:0008323)2.40625043
79Gingivitis (HP:0000230)2.40089366
80Encephalitis (HP:0002383)2.39490178
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.37687888
82Protruding tongue (HP:0010808)2.36534021
83Nephronophthisis (HP:0000090)2.36267675
84Decreased circulating renin level (HP:0003351)2.36151718
85Lymphoma (HP:0002665)2.34958416
86True hermaphroditism (HP:0010459)2.34548014
87Hemoptysis (HP:0002105)2.34434430
88Abnormality of the renal medulla (HP:0100957)2.31733539
89Chronic sinusitis (HP:0011109)2.28691372
90Verrucae (HP:0200043)2.28000845
91Papilloma (HP:0012740)2.28000845
92Hypochromic microcytic anemia (HP:0004840)2.27765128
93Joint swelling (HP:0001386)2.27584296
94Abnormality of the prostate (HP:0008775)2.26177448
95Renal cortical cysts (HP:0000803)2.24420181
96Autoimmune hemolytic anemia (HP:0001890)2.24307253
97Abnormality of macrophages (HP:0004311)2.23685810
98Gastrointestinal stroma tumor (HP:0100723)2.22439469
99Chronic hepatic failure (HP:0100626)2.22148822
100Poikiloderma (HP:0001029)2.21419743
101Chest pain (HP:0100749)2.20484399
102Abolished electroretinogram (ERG) (HP:0000550)2.19258428
103Clubbing of toes (HP:0100760)2.19131383
104Impaired platelet aggregation (HP:0003540)2.18807577
105Abnormal platelet function (HP:0011869)2.18807577
106Prostate neoplasm (HP:0100787)2.18751336
107Fatigue (HP:0012378)2.14149438
108Optic neuritis (HP:0100653)2.13470987
109Retrobulbar optic neuritis (HP:0100654)2.13470987
110Acute myeloid leukemia (HP:0004808)2.11037192
111Hyperventilation (HP:0002883)2.10606910
112Hypochromic anemia (HP:0001931)2.09885168
113Congenital sensorineural hearing impairment (HP:0008527)2.06873783
114Basal cell carcinoma (HP:0002671)2.06557706
115Constricted visual fields (HP:0001133)2.06458170
116Recurrent gram-negative bacterial infections (HP:0005420)2.05044383
117Bronchiectasis (HP:0002110)2.04980866
118Orchitis (HP:0100796)2.04569381
119Gastrointestinal infarctions (HP:0005244)2.02550124
120Osteomyelitis (HP:0002754)2.02361340
121Ureteral stenosis (HP:0000071)2.01492763
122Cystic liver disease (HP:0006706)2.00718940
123Arterial thrombosis (HP:0004420)2.00101130
124Hypoproteinemia (HP:0003075)1.98712075
125Gingival bleeding (HP:0000225)1.97900349
126Bronchitis (HP:0012387)1.97304959
127Prominent nose (HP:0000448)1.96371557
128Urethral obstruction (HP:0000796)1.96122372
129Depressed nasal tip (HP:0000437)1.92602750
130Increased mean platelet volume (HP:0011877)1.91961768
131Abnormal ciliary motility (HP:0012262)1.91338884
132Sepsis (HP:0100806)1.90796571
133Abnormality of DNA repair (HP:0003254)1.90683750
134Gaze-evoked nystagmus (HP:0000640)1.89937317
135Tubular atrophy (HP:0000092)1.89293436
136Medial flaring of the eyebrow (HP:0010747)1.88204252
137Aplasia/Hypoplasia of the uvula (HP:0010293)1.87908267
138Recurrent sinusitis (HP:0011108)1.87720132
139Polydipsia (HP:0001959)1.87399346
140Abnormal drinking behavior (HP:0030082)1.87399346
141Skin ulcer (HP:0200042)1.86960531
142Frequent falls (HP:0002359)1.84388108
143Ureteral obstruction (HP:0006000)1.82961605
144Amaurosis fugax (HP:0100576)1.82653788
145Pulmonary infiltrates (HP:0002113)1.82568280
146Hyperacusis (HP:0010780)1.82185054
147Bile duct proliferation (HP:0001408)1.81911329
148Abnormal biliary tract physiology (HP:0012439)1.81911329
149Progressive inability to walk (HP:0002505)1.81735861
150Abnormality of the pons (HP:0007361)1.81699596
151Bony spicule pigmentary retinopathy (HP:0007737)1.79140075
152Genetic anticipation (HP:0003743)1.77919590

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.38789891
2MAP4K15.11319161
3TXK4.31794255
4ZAP702.99162589
5EEF2K2.86837328
6STK102.63727512
7TEC2.63420589
8ITK2.58674251
9BTK2.57425010
10ACVR1B2.54725241
11JAK32.40696513
12GRK62.37738410
13MAP3K102.21335522
14IRAK42.14380329
15ADRBK21.90307880
16KIT1.90033542
17TAOK31.88822548
18IKBKE1.83131607
19SIK21.82626573
20TYK21.82415541
21ZAK1.76297703
22BLK1.69475458
23LRRK21.66597825
24GRK11.64088490
25SYK1.63283488
26LCK1.59272643
27TLK11.58698173
28INSRR1.53693952
29TBK11.48545016
30HCK1.48009303
31PIK3CG1.41236930
32JAK11.37984822
33KDR1.37681546
34MST41.36824799
35OXSR11.32589294
36PTK2B1.31898012
37RPS6KA41.31419728
38CAMKK21.29481086
39MAP2K31.26671270
40PIM11.25329928
41IRAK11.25294678
42TESK21.25259451
43MARK31.24706713
44STK391.22775990
45RIPK41.22334393
46IRAK31.20167364
47TGFBR21.18363558
48BMPR1B1.18177165
49FGFR31.14781387
50CSK1.14773299
51WNK41.14743900
52MAP3K141.13510154
53PKN21.13360009
54FES1.11829769
55MAPK131.08194908
56FGFR41.07961970
57TGFBR11.04991488
58NEK21.04688012
59TNK20.99509362
60TRPM70.98719727
61CDK120.98591017
62LYN0.96804878
63CSF1R0.96230493
64MAP4K20.92709196
65EPHB10.92467677
66NLK0.92091058
67WNK30.88258719
68SIK30.86827848
69TSSK60.85165767
70RPS6KB20.84065408
71PRKG20.81056396
72MAP2K20.78969216
73IKBKB0.77009708
74PRKCQ0.76429646
75DMPK0.75785112
76MAP3K130.73808679
77SRPK10.72795816
78STK40.71997376
79TTN0.68981812
80CDK40.68485600
81CHUK0.67556902
82ADRBK10.64600152
83BMPR20.63602624
84MAP3K70.62711986
85NUAK10.62223330
86FLT30.61905301
87BUB10.61492468
88EIF2AK30.61397622
89EPHA30.60530843
90CLK10.59465294
91MARK20.55659682
92NME20.54684548
93BCKDK0.53003754
94CDC70.52253441
95MAP3K80.51805186
96MAP2K60.49364764
97WNK10.49246180
98JAK20.47109854
99MAPK70.45969959
100CAMK1D0.45588229
101ERN10.45178109
102WEE10.43069029
103PTK60.42323216
104ALK0.41907006
105STK240.41138882
106SGK20.40962634
107TIE10.40411713
108RPS6KA60.40263119
109PDGFRB0.38973338
110PASK0.38818880
111FYN0.38355506
112NME10.37655475
113TAOK10.37293815
114AURKB0.37230169
115MATK0.36828483
116PRKAA20.36766282
117MAP3K40.36527479
118PIK3CA0.36273925
119MUSK0.35558132
120LMTK20.35418655
121PAK30.34875260
122EIF2AK20.34304047
123MAPK110.33803399
124PRKCH0.33206451
125MAPKAPK30.33067458
126SGK30.32509024
127HIPK20.32075174
128SIK10.32032982
129PDK10.32021895
130RPS6KA50.31752368
131EIF2AK10.30985275
132ABL10.30956096
133MAPK40.30577710
134MAPKAPK20.30508160
135RAF10.30292542
136ATR0.30125591
137MAPK120.26746436
138MELK0.26196284
139YES10.26012140
140IGF1R0.25007228
141PRKCI0.22666200

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053404.27544000
2Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046502.73715032
3T cell receptor signaling pathway_Homo sapiens_hsa046602.69232273
4Antigen processing and presentation_Homo sapiens_hsa046122.59004426
5Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.44255534
6Measles_Homo sapiens_hsa051622.43036201
7Graft-versus-host disease_Homo sapiens_hsa053322.33573258
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.32475382
9Leishmaniasis_Homo sapiens_hsa051402.30721845
10B cell receptor signaling pathway_Homo sapiens_hsa046622.22347519
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.18704594
12Linoleic acid metabolism_Homo sapiens_hsa005912.10546643
13Osteoclast differentiation_Homo sapiens_hsa043802.08610707
14alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.05912609
15Hematopoietic cell lineage_Homo sapiens_hsa046401.91615426
16Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.89319497
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.76399372
18Leukocyte transendothelial migration_Homo sapiens_hsa046701.71298929
19Caffeine metabolism_Homo sapiens_hsa002321.67414030
20Jak-STAT signaling pathway_Homo sapiens_hsa046301.55954180
21Allograft rejection_Homo sapiens_hsa053301.55052794
22Nitrogen metabolism_Homo sapiens_hsa009101.55050862
23NOD-like receptor signaling pathway_Homo sapiens_hsa046211.51210633
24DNA replication_Homo sapiens_hsa030301.50956329
25Viral myocarditis_Homo sapiens_hsa054161.48389361
26Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.45502731
27Fanconi anemia pathway_Homo sapiens_hsa034601.45448095
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.44230485
29Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.40176712
30Phototransduction_Homo sapiens_hsa047441.39211811
31Herpes simplex infection_Homo sapiens_hsa051681.36108045
32Acute myeloid leukemia_Homo sapiens_hsa052211.35749737
33Base excision repair_Homo sapiens_hsa034101.35341782
34Shigellosis_Homo sapiens_hsa051311.35292551
35Platelet activation_Homo sapiens_hsa046111.30646709
36ABC transporters_Homo sapiens_hsa020101.30439043
37RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.27074825
38Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.26230454
39Toxoplasmosis_Homo sapiens_hsa051451.25977578
40Influenza A_Homo sapiens_hsa051641.21661007
41Ether lipid metabolism_Homo sapiens_hsa005651.18677074
42Chemokine signaling pathway_Homo sapiens_hsa040621.17885876
43Transcriptional misregulation in cancer_Homo sapiens_hsa052021.16914820
44Hepatitis B_Homo sapiens_hsa051611.14754477
45Carbohydrate digestion and absorption_Homo sapiens_hsa049731.14360768
46Apoptosis_Homo sapiens_hsa042101.12928577
47Renin-angiotensin system_Homo sapiens_hsa046141.10356420
48Tryptophan metabolism_Homo sapiens_hsa003801.09933245
49Toll-like receptor signaling pathway_Homo sapiens_hsa046201.07214734
50Legionellosis_Homo sapiens_hsa051341.06779002
51Mismatch repair_Homo sapiens_hsa034301.05897095
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.03700704
53Epstein-Barr virus infection_Homo sapiens_hsa051691.02717032
54Salmonella infection_Homo sapiens_hsa051321.00448538
55Tuberculosis_Homo sapiens_hsa051520.99720113
56Galactose metabolism_Homo sapiens_hsa000520.99204152
57Ribosome_Homo sapiens_hsa030100.99141077
58Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.98529199
59Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.97409178
60Non-homologous end-joining_Homo sapiens_hsa034500.95871647
61Glycerolipid metabolism_Homo sapiens_hsa005610.94469820
62Pentose phosphate pathway_Homo sapiens_hsa000300.94174430
63Pancreatic cancer_Homo sapiens_hsa052120.92661496
64TNF signaling pathway_Homo sapiens_hsa046680.90673800
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.90007317
66Arachidonic acid metabolism_Homo sapiens_hsa005900.89245935
67HTLV-I infection_Homo sapiens_hsa051660.89222094
68Rheumatoid arthritis_Homo sapiens_hsa053230.88974302
69Viral carcinogenesis_Homo sapiens_hsa052030.87211909
70Chronic myeloid leukemia_Homo sapiens_hsa052200.86053646
71Dorso-ventral axis formation_Homo sapiens_hsa043200.84761375
72Other glycan degradation_Homo sapiens_hsa005110.84738415
73Butanoate metabolism_Homo sapiens_hsa006500.81949257
74Autoimmune thyroid disease_Homo sapiens_hsa053200.80314129
75AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.79891375
76VEGF signaling pathway_Homo sapiens_hsa043700.79592895
77Neurotrophin signaling pathway_Homo sapiens_hsa047220.78759026
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.78289057
79Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76511174
80Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.75403922
81Chemical carcinogenesis_Homo sapiens_hsa052040.74721731
82Olfactory transduction_Homo sapiens_hsa047400.74692038
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.74172155
84Malaria_Homo sapiens_hsa051440.73969817
85Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.73365699
86Taste transduction_Homo sapiens_hsa047420.73347461
87Hepatitis C_Homo sapiens_hsa051600.73091663
88Spliceosome_Homo sapiens_hsa030400.72994327
89Colorectal cancer_Homo sapiens_hsa052100.72993605
90Maturity onset diabetes of the young_Homo sapiens_hsa049500.72713070
91Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.70611966
92Pertussis_Homo sapiens_hsa051330.70449649
93Selenocompound metabolism_Homo sapiens_hsa004500.70197732
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.69761637
95Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.67489132
96Regulation of autophagy_Homo sapiens_hsa041400.66453457
97Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65954023
98Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.64676123
99Inositol phosphate metabolism_Homo sapiens_hsa005620.63125711
100Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.61728058
101Non-small cell lung cancer_Homo sapiens_hsa052230.57882830
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.56924020
103Ovarian steroidogenesis_Homo sapiens_hsa049130.56894922
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53983492
105Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.52603813
106Insulin resistance_Homo sapiens_hsa049310.51716192
107RNA polymerase_Homo sapiens_hsa030200.49631154
108Type I diabetes mellitus_Homo sapiens_hsa049400.49542776
109Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49183233
110p53 signaling pathway_Homo sapiens_hsa041150.48196499
111Asthma_Homo sapiens_hsa053100.48144637
112Staphylococcus aureus infection_Homo sapiens_hsa051500.48093667
113Fructose and mannose metabolism_Homo sapiens_hsa000510.48020693
114Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.47867703
115Vitamin digestion and absorption_Homo sapiens_hsa049770.47057484
116Homologous recombination_Homo sapiens_hsa034400.46597094
117Calcium signaling pathway_Homo sapiens_hsa040200.46103118
118Basal transcription factors_Homo sapiens_hsa030220.45656134
119Prolactin signaling pathway_Homo sapiens_hsa049170.45473467
120Serotonergic synapse_Homo sapiens_hsa047260.45060973
121Salivary secretion_Homo sapiens_hsa049700.44119821
122Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.43898173
123Regulation of actin cytoskeleton_Homo sapiens_hsa048100.43837255
124Retinol metabolism_Homo sapiens_hsa008300.42810258
125African trypanosomiasis_Homo sapiens_hsa051430.42633990
126HIF-1 signaling pathway_Homo sapiens_hsa040660.42587793
127Notch signaling pathway_Homo sapiens_hsa043300.42460231
128Endocytosis_Homo sapiens_hsa041440.41865233
129Small cell lung cancer_Homo sapiens_hsa052220.41662703
130Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41498635
131Cell cycle_Homo sapiens_hsa041100.40195432
132Lysine degradation_Homo sapiens_hsa003100.38453187
133Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.38322889
134Systemic lupus erythematosus_Homo sapiens_hsa053220.37075661
135Vascular smooth muscle contraction_Homo sapiens_hsa042700.36687400
136FoxO signaling pathway_Homo sapiens_hsa040680.36666531
137Rap1 signaling pathway_Homo sapiens_hsa040150.36126664
138Fat digestion and absorption_Homo sapiens_hsa049750.35533370
139Type II diabetes mellitus_Homo sapiens_hsa049300.34903215
140Nucleotide excision repair_Homo sapiens_hsa034200.34354362
141Morphine addiction_Homo sapiens_hsa050320.33784071
142Cyanoamino acid metabolism_Homo sapiens_hsa004600.31594867
143RNA transport_Homo sapiens_hsa030130.31491965
144mTOR signaling pathway_Homo sapiens_hsa041500.28304494

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