CRACR2B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1semaphorin-plexin signaling pathway (GO:0071526)5.71009381
2negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)5.44548889
3surfactant homeostasis (GO:0043129)5.24721035
4pattern specification involved in kidney development (GO:0061004)4.91111585
5regulation of hydrogen peroxide metabolic process (GO:0010310)4.88847915
6regulation of ruffle assembly (GO:1900027)4.70414877
7negative regulation of cell size (GO:0045792)4.63236534
8endothelial cell chemotaxis (GO:0035767)4.51944049
9chemical homeostasis within a tissue (GO:0048875)4.36040286
10lymph vessel development (GO:0001945)4.31526593
11peptidyl-tyrosine autophosphorylation (GO:0038083)4.24813346
12positive regulation of histone deacetylation (GO:0031065)4.19450182
13bundle of His cell to Purkinje myocyte communication (GO:0086069)4.08957481
14ear development (GO:0043583)4.02070620
15Golgi transport vesicle coating (GO:0048200)3.99506418
16COPI coating of Golgi vesicle (GO:0048205)3.99506418
17mannose metabolic process (GO:0006013)3.97645009
18planar cell polarity pathway involved in neural tube closure (GO:0090179)3.87794014
19epithelial cell-cell adhesion (GO:0090136)3.84608855
20regulation of endothelial cell differentiation (GO:0045601)3.83458438
21axonemal dynein complex assembly (GO:0070286)3.80286228
22glutathione biosynthetic process (GO:0006750)3.67534536
23lung epithelium development (GO:0060428)3.67513826
24cell-cell junction maintenance (GO:0045217)3.66255823
25GDP-mannose metabolic process (GO:0019673)3.63875052
26positive regulation of protein kinase C signaling (GO:0090037)3.62536434
27motile cilium assembly (GO:0044458)3.62411418
28establishment of apical/basal cell polarity (GO:0035089)3.59483855
29positive regulation of Cdc42 GTPase activity (GO:0043089)3.57238095
30Rho protein signal transduction (GO:0007266)3.55833954
31proline biosynthetic process (GO:0006561)3.48323270
32regulation of ARF GTPase activity (GO:0032312)3.45919332
33regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.45006700
34activation of Rac GTPase activity (GO:0032863)3.44178888
35regulation of respiratory burst (GO:0060263)3.43713903
36definitive hemopoiesis (GO:0060216)3.43675789
37insulin-like growth factor receptor signaling pathway (GO:0048009)3.40214285
38positive regulation of endothelial cell differentiation (GO:0045603)3.36863587
39nonribosomal peptide biosynthetic process (GO:0019184)3.31307772
40retina vasculature morphogenesis in camera-type eye (GO:0061299)3.29853369
41negative regulation of keratinocyte proliferation (GO:0010839)3.29050869
42desmosome organization (GO:0002934)3.28373735
43blood vessel maturation (GO:0001955)3.28114166
44positive regulation of triglyceride metabolic process (GO:0090208)3.26577650
45regulation of apoptotic cell clearance (GO:2000425)3.22810380
46detection of other organism (GO:0098543)3.22435913
47primary alcohol catabolic process (GO:0034310)3.21886884
48detection of molecule of bacterial origin (GO:0032490)3.20143352
49hemidesmosome assembly (GO:0031581)3.18470483
50negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.16646167
51quaternary ammonium group transport (GO:0015697)3.16241677
52apoptotic process involved in morphogenesis (GO:0060561)3.13313933
53regulation of Cdc42 GTPase activity (GO:0043088)3.12026274
54proline metabolic process (GO:0006560)3.09534262
55histone H4 deacetylation (GO:0070933)3.08172320
56one-carbon compound transport (GO:0019755)3.07762285
57superoxide anion generation (GO:0042554)3.06396183
58regulation of vasculogenesis (GO:2001212)3.01735468
59cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.01491712
60face development (GO:0060324)3.01366557
61regulation of extracellular matrix disassembly (GO:0010715)3.00636062
62retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.99644370
63positive regulation of protein deacetylation (GO:0090312)2.99442925
64negative regulation of erythrocyte differentiation (GO:0045647)2.98229486
65ethanol metabolic process (GO:0006067)2.97062576
66diacylglycerol metabolic process (GO:0046339)2.96480502
67positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.94522576
68response to manganese ion (GO:0010042)2.93496973
69regulation of cholesterol metabolic process (GO:0090181)2.93409549
70negative regulation of osteoblast proliferation (GO:0033689)2.93368374
71regulation of cholesterol biosynthetic process (GO:0045540)2.91463122
72regulation of clathrin-mediated endocytosis (GO:2000369)2.90692978
73regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.88330651
74phagocytosis, recognition (GO:0006910)2.87429550
75cell junction maintenance (GO:0034331)2.87012204
76negative regulation of protein autophosphorylation (GO:0031953)2.85988411
77establishment of monopolar cell polarity (GO:0061162)2.85699213
78establishment or maintenance of monopolar cell polarity (GO:0061339)2.85699213
79detection of external biotic stimulus (GO:0098581)2.84744633
80lymphangiogenesis (GO:0001946)2.83040883
81transcytosis (GO:0045056)2.81697187
82mammary gland epithelial cell differentiation (GO:0060644)2.79025035
83amyloid precursor protein catabolic process (GO:0042987)2.78660189
84vitamin transmembrane transport (GO:0035461)2.76577804
85maternal placenta development (GO:0001893)2.76322814
86white fat cell differentiation (GO:0050872)2.75439207
87response to magnesium ion (GO:0032026)2.71951934
88regulation of fatty acid beta-oxidation (GO:0031998)2.69809761
89protein kinase C signaling (GO:0070528)2.69166321
90negative regulation of viral release from host cell (GO:1902187)2.68681958
91histone H3 deacetylation (GO:0070932)2.67934235
92endothelium development (GO:0003158)2.67282806
93lipoxygenase pathway (GO:0019372)2.67045206
94regulation of histone deacetylation (GO:0031063)2.65531584
95protein retention in ER lumen (GO:0006621)2.63665654
96branching involved in mammary gland duct morphogenesis (GO:0060444)2.63224573
97phospholipid scrambling (GO:0017121)2.61247541
98peptide catabolic process (GO:0043171)2.59238389
99actin filament bundle assembly (GO:0051017)2.59211328
100actin filament bundle organization (GO:0061572)2.59211328
101vascular endothelial growth factor signaling pathway (GO:0038084)2.58889046
102regulation of apoptotic process involved in morphogenesis (GO:1902337)2.58542785
103cytoskeletal anchoring at plasma membrane (GO:0007016)2.58503936
104detection of bacterium (GO:0016045)2.57626441
105lung secretory cell differentiation (GO:0061140)2.56874812
106regulation of glucose import in response to insulin stimulus (GO:2001273)2.55484598
107snRNA metabolic process (GO:0016073)2.54119211
108regulation of cellular extravasation (GO:0002691)2.52992349
109response to peptidoglycan (GO:0032494)2.52967811
110embryonic camera-type eye development (GO:0031076)2.52378678
111adherens junction assembly (GO:0034333)2.52016291
112regulation of chromatin binding (GO:0035561)2.51621932
113positive regulation of lipid catabolic process (GO:0050996)2.50534821
114cell volume homeostasis (GO:0006884)2.50240768
115regulation of cholesterol homeostasis (GO:2000188)2.49419437
116water homeostasis (GO:0030104)2.49014211
117positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.48903579
118phosphatidylglycerol biosynthetic process (GO:0006655)2.48272600
119positive regulation of epidermal cell differentiation (GO:0045606)2.48149431
120regulation of receptor binding (GO:1900120)2.47765902
121basement membrane organization (GO:0071711)2.47227042
122negative regulation of protein tyrosine kinase activity (GO:0061099)2.47138602
123activation of JUN kinase activity (GO:0007257)2.46073718
124negative regulation of platelet activation (GO:0010544)2.45450906
125positive regulation of triglyceride biosynthetic process (GO:0010867)2.45389906
126peptide biosynthetic process (GO:0043043)2.44528308
127positive regulation of respiratory burst (GO:0060267)2.43490161
128keratinocyte development (GO:0003334)2.42995716
129negative regulation of systemic arterial blood pressure (GO:0003085)2.42628124
130positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.42315097
131negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.39278118
132regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.39258678
133endothelial cell differentiation (GO:0045446)2.38925754
134response to progesterone (GO:0032570)2.38666190
135positive regulation of keratinocyte differentiation (GO:0045618)2.37907432
136T-helper 1 type immune response (GO:0042088)2.37458113
137interleukin-1-mediated signaling pathway (GO:0070498)2.36543828
138regulation of interleukin-8 secretion (GO:2000482)2.36530611
139establishment of skin barrier (GO:0061436)2.35172341
140negative regulation of nitric oxide biosynthetic process (GO:0045019)2.35152150
141wound healing, spreading of epidermal cells (GO:0035313)2.34403655
142growth hormone receptor signaling pathway (GO:0060396)2.34072963
143regulation of toll-like receptor 4 signaling pathway (GO:0034143)2.32090789
144atrioventricular valve morphogenesis (GO:0003181)2.32089006
145facial nerve structural organization (GO:0021612)2.31618115
146detection of biotic stimulus (GO:0009595)2.31232727
147artery development (GO:0060840)2.31141947
148sphingosine metabolic process (GO:0006670)2.30015471
149leukotriene metabolic process (GO:0006691)2.29187917
150energy homeostasis (GO:0097009)2.29143819
151morphogenesis of an endothelium (GO:0003159)2.28305633
152endothelial tube morphogenesis (GO:0061154)2.28305633
153cyclooxygenase pathway (GO:0019371)2.27850939
154purinergic nucleotide receptor signaling pathway (GO:0035590)2.27643642
155ceramide catabolic process (GO:0046514)2.27176968
156sodium-independent organic anion transport (GO:0043252)2.26248237
157neuron remodeling (GO:0016322)2.25921833
158exocrine pancreas development (GO:0031017)2.25750577
159regulation of water loss via skin (GO:0033561)2.25168651
160positive regulation of T cell chemotaxis (GO:0010820)2.24965187
161regulation of T cell chemotaxis (GO:0010819)2.24965187
162sphingoid metabolic process (GO:0046519)2.24782956
163dendritic cell chemotaxis (GO:0002407)2.24641555
164positive regulation of p38MAPK cascade (GO:1900745)2.24150067
165L-fucose metabolic process (GO:0042354)2.23728729
166L-fucose catabolic process (GO:0042355)2.23728729
167fucose catabolic process (GO:0019317)2.23728729
168heart valve formation (GO:0003188)2.22745612
169polyol transport (GO:0015791)2.22438409
170negative regulation of nitric-oxide synthase activity (GO:0051001)2.22254713
171negative regulation of transcription by competitive promoter binding (GO:0010944)2.21316751
172response to interferon-alpha (GO:0035455)2.20826705
173positive regulation of natural killer cell differentiation (GO:0032825)2.20689010
174regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.19423375
175diol metabolic process (GO:0034311)2.18086308
176regulation of somitogenesis (GO:0014807)2.17021388
177adhesion of symbiont to host (GO:0044406)2.16755577
178angiogenesis involved in wound healing (GO:0060055)2.16031559
179positive regulation of chemokine secretion (GO:0090197)2.15250099
180negative regulation of homotypic cell-cell adhesion (GO:0034111)2.15140634
181glomerular visceral epithelial cell development (GO:0072015)2.14927713
182calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.14747497
183multicellular organismal water homeostasis (GO:0050891)2.14099202
184regulation of heat generation (GO:0031650)2.13835903
185regulation of cell proliferation involved in kidney development (GO:1901722)2.12794987
186Notch signaling involved in heart development (GO:0061314)2.12656687
187norepinephrine metabolic process (GO:0042415)2.11848845
188response to interferon-beta (GO:0035456)2.11501424
189dendritic cell migration (GO:0036336)2.11244769

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TP63_17297297_ChIP-ChIP_HaCaT_Human5.61556019
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.03862348
3TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.47350663
4STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse3.34287992
5ESR1_21235772_ChIP-Seq_MCF-7_Human3.17979792
6LXR_22292898_ChIP-Seq_THP-1_Human3.00688571
7ZNF263_19887448_ChIP-Seq_K562_Human2.84189897
8TRIM28_21343339_ChIP-Seq_HEK293_Human2.56650605
9GATA2_21666600_ChIP-Seq_HMVEC_Human2.46704392
10ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.45940926
11ESR2_21235772_ChIP-Seq_MCF-7_Human2.36951263
12KDM2B_26808549_Chip-Seq_SUP-B15_Human2.31862714
13TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19104567
14FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.16421786
15P68_20966046_ChIP-Seq_HELA_Human2.16298870
16CDX2_19796622_ChIP-Seq_MESCs_Mouse2.16173286
17CDX2_20551321_ChIP-Seq_CACO-2_Human2.15550729
18SCL_19346495_ChIP-Seq_HPC-7_Human2.13749075
19EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.12158782
20CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.11818646
21KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.10059352
22VDR_21846776_ChIP-Seq_THP-1_Human2.09867339
23PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.08864569
24PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse2.02022472
25IRF8_22096565_ChIP-ChIP_GC-B_Human1.97411318
26SOX2_20726797_ChIP-Seq_SW620_Human1.95106831
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.92755680
28KDM2B_26808549_Chip-Seq_DND41_Human1.92471406
29CREB1_26743006_Chip-Seq_LNCaP_Human1.87766433
30TCF7_22412390_ChIP-Seq_EML_Mouse1.84973118
31IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.82395941
32CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.78827719
33ERG_21242973_ChIP-ChIP_JURKAT_Human1.78124291
34KDM2B_26808549_Chip-Seq_K562_Human1.77585637
35CTCF_27219007_Chip-Seq_Bcells_Human1.75244810
36TET1_21451524_ChIP-Seq_MESCs_Mouse1.74170788
37SMC4_20622854_ChIP-Seq_HELA_Human1.73405680
38SA1_27219007_Chip-Seq_ERYTHROID_Human1.71667464
39KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.71086653
40KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.71086653
41KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.71086653
42ESR1_20079471_ChIP-ChIP_T-47D_Human1.68331702
43UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.66468108
44CTCF_27219007_Chip-Seq_ERYTHROID_Human1.66145124
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.65206303
46EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.63027828
47SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.60344804
48KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.59334048
49SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.58484506
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.58052436
51P63_26484246_Chip-Seq_KERATINOCYTES_Human1.57228063
52KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.56746565
53CJUN_26792858_Chip-Seq_BT549_Human1.55573296
54PPAR_26484153_Chip-Seq_NCI-H1993_Human1.54700370
55SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52682644
56SOX9_24532713_ChIP-Seq_HFSC_Mouse1.52213412
57CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.51764852
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.50921705
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.50769056
60PPARA_22158963_ChIP-Seq_LIVER_Mouse1.50741474
61ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50650415
62CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.49993175
63LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.49170391
64DROSHA_22980978_ChIP-Seq_HELA_Human1.49077376
65THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.49021998
66ZFP281_18757296_ChIP-ChIP_E14_Mouse1.48077373
67SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.47922248
68BCOR_27268052_Chip-Seq_Bcells_Human1.46287325
69AHR_22903824_ChIP-Seq_MCF-7_Human1.45429503
70SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.44300833
71SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.44300833
72MYC_22102868_ChIP-Seq_BL_Human1.43932011
73BCL6_27268052_Chip-Seq_Bcells_Human1.43903986
74ELF1_20517297_ChIP-Seq_JURKAT_Human1.43106345
75IRF8_27001747_Chip-Seq_BMDM_Mouse1.42938066
76RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.41526477
77SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.41232775
78STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39651860
79KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.35816904
80STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.32929127
81DNAJC2_21179169_ChIP-ChIP_NT2_Human1.32528131
82TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.32029459
83GATA4_25053715_ChIP-Seq_YYC3_Human1.31429454
84TP63_22573176_ChIP-Seq_HFKS_Human1.30853452
85ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.30799562
86RXR_22158963_ChIP-Seq_LIVER_Mouse1.30505911
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27945521
88RARB_24833708_ChIP-Seq_LIVER_Mouse1.27200909
89PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.24681719
90PHF8_20622854_ChIP-Seq_HELA_Human1.23555562
91E2F1_20622854_ChIP-Seq_HELA_Human1.23323556
92TP53_18474530_ChIP-ChIP_U2OS_Human1.21913051
93NCOR1_26117541_ChIP-Seq_K562_Human1.20368117
94ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.18087782
95SA1_27219007_Chip-Seq_Bcells_Human1.17536557
96SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.16609182
97FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.16123337
98SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15682593
99EP300_21415370_ChIP-Seq_HL-1_Mouse1.14929377
100NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14528869
101ATF3_27146783_Chip-Seq_COLON_Human1.14345858
102CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.14045995
103GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13728008
104MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.13158553
105WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.13139646
106E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.12901825
107TET1_21490601_ChIP-Seq_MESCs_Mouse1.11809803
108GATA1_22025678_ChIP-Seq_K562_Human1.10971109
109CTCF_26484167_Chip-Seq_Bcells_Mouse1.10407709
110SOX2_27498859_Chip-Seq_STOMACH_Mouse1.10246213
111TP53_22127205_ChIP-Seq_IMR90_Human1.10008841
112KDM2B_26808549_Chip-Seq_JURKAT_Human1.09719952
113NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.09651234
114NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.09510377
115VDR_24787735_ChIP-Seq_THP-1_Human1.09232569
116STAT3_1855785_ChIP-Seq_MESCs_Mouse1.09190502
117EED_16625203_ChIP-ChIP_MESCs_Mouse1.09000043
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.08882299
119DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.08225442
120KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.07608333
121ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.07486548
122TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.07478389
123LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.06835657
124PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.06363657
125BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05265495
126MYB_21317192_ChIP-Seq_ERMYB_Mouse1.04956436
127TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04446543
128TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04078095
129CTCF_20526341_ChIP-Seq_ESCs_Human1.03963982
130GATA6_25053715_ChIP-Seq_YYC3_Human1.03727384
131RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.03626077
132P300_27058665_Chip-Seq_ZR-75-30cells_Human1.03613222
133HIF1A_21447827_ChIP-Seq_MCF-7_Human1.02649981
134MAF_26560356_Chip-Seq_TH2_Human1.02201257
135NFIB_24661679_ChIP-Seq_LUNG_Mouse1.01506973
136ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.01089369
137ZFP281_27345836_Chip-Seq_ESCs_Mouse1.00910497
138VDR_24763502_ChIP-Seq_THP-1_Human1.00522244
139ARNT_22903824_ChIP-Seq_MCF-7_Human0.99887951
140RAD21_21589869_ChIP-Seq_MESCs_Mouse0.99861392
141RARA_24833708_ChIP-Seq_LIVER_Mouse0.99650849
142FOXO3_23340844_ChIP-Seq_DLD1_Human0.99642955
143CTCF_21964334_ChIP-Seq_BJAB-B_Human0.99556068
144CTCF_21964334_Chip-Seq_Bcells_Human0.99090443
145CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.98466398
146KLF5_25053715_ChIP-Seq_YYC3_Human0.98419532
147STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.97779413
148SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.96592038
149RUNX_20019798_ChIP-Seq_JUKART_Human0.96228079
150CLOCK_20551151_ChIP-Seq_293T_Human0.95683518
151RUNX1_27514584_Chip-Seq_MCF-7_Human0.95218427
152BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.94491777
153SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.94110282
154CBX2_27304074_Chip-Seq_ESCs_Mouse0.93172903
155SALL4_18804426_ChIP-ChIP_XEN_Mouse0.93110400
156ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.92796512
157RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.90956550
158NOTCH1_21737748_ChIP-Seq_TLL_Human0.89177995
159MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.88868275
160TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.84668342
161SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.83678912
162TBX20_22328084_ChIP-Seq_HEART_Mouse0.81859119
163TBX20_22080862_ChIP-Seq_HEART_Mouse0.81859119
164BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.80121824
165SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.79268027
166JARID2_20075857_ChIP-Seq_MESCs_Mouse0.78777046
167TCF4_18268006_ChIP-ChIP_LS174T_Human0.78545845
168ELK3_25401928_ChIP-Seq_HUVEC_Human0.77584102
169EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.77176465
170SMAD_19615063_ChIP-ChIP_OVARY_Human0.76988393
171PCGF2_27294783_Chip-Seq_NPCs_Mouse0.76315282
172PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.76152140
173FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.75890159
174MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.75607811
175SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.75481814
176PIAS1_25552417_ChIP-Seq_VCAP_Human0.74992881
177RACK7_27058665_Chip-Seq_MCF-7_Human0.74622481

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to4.06324911
2MP0001849_ear_inflammation3.52233441
3MP0005083_abnormal_biliary_tract3.40962984
4MP0001879_abnormal_lymphatic_vessel3.23528240
5MP0010368_abnormal_lymphatic_system3.19443423
6MP0009384_cardiac_valve_regurgitation3.17623276
7MP0003172_abnormal_lysosome_physiology3.13881787
8MP0003705_abnormal_hypodermis_morpholog3.12825672
9MP0002254_reproductive_system_inflammat2.90344695
10MP0000678_abnormal_parathyroid_gland2.84588874
11MP0000566_synostosis2.61962390
12MP0004782_abnormal_surfactant_physiolog2.61186018
13MP0001881_abnormal_mammary_gland2.50873452
14MP0003941_abnormal_skin_development2.47000826
15MP0008260_abnormal_autophagy2.45486283
16MP0003828_pulmonary_edema2.45114747
17MP0003136_yellow_coat_color2.39774418
18MP0001873_stomach_inflammation2.35587542
19MP0005076_abnormal_cell_differentiation2.25710057
20MP0004272_abnormal_basement_membrane2.19142473
21MP0008004_abnormal_stomach_pH2.18250485
22MP0004858_abnormal_nervous_system2.13552157
23MP0005167_abnormal_blood-brain_barrier2.12051650
24MP0004381_abnormal_hair_follicle2.01657288
25MP0005360_urolithiasis2.00289482
26MP0002098_abnormal_vibrissa_morphology1.96890282
27MP0002138_abnormal_hepatobiliary_system1.95712288
28MP0000465_gastrointestinal_hemorrhage1.94426923
29MP0002822_catalepsy1.91782536
30MP0010030_abnormal_orbit_morphology1.84802409
31MP0000751_myopathy1.81922104
32MP0010234_abnormal_vibrissa_follicle1.79715593
33MP0002653_abnormal_ependyma_morphology1.77001468
34MP0002796_impaired_skin_barrier1.72236244
35MP0001958_emphysema1.70276660
36MP0002132_abnormal_respiratory_system1.69193805
37MP0006138_congestive_heart_failure1.67759150
38MP0006054_spinal_hemorrhage1.65388745
39MP0005666_abnormal_adipose_tissue1.64086163
40MP0009379_abnormal_foot_pigmentation1.63669353
41MP0002277_abnormal_respiratory_mucosa1.58042033
42MP0009278_abnormal_bone_marrow1.56335252
43MP0002148_abnormal_hypersensitivity_rea1.55493016
44MP0008995_early_reproductive_senescence1.55167499
45MP0005375_adipose_tissue_phenotype1.51038214
46MP0001502_abnormal_circadian_rhythm1.49158889
47MP0000013_abnormal_adipose_tissue1.47271025
48MP0000003_abnormal_adipose_tissue1.45441200
49MP0003878_abnormal_ear_physiology1.42193375
50MP0005377_hearing/vestibular/ear_phenot1.42193375
51MP0001348_abnormal_lacrimal_gland1.38260864
52MP0009785_altered_susceptibility_to1.36657471
53MP0002060_abnormal_skin_morphology1.35323511
54MP0000613_abnormal_salivary_gland1.34601171
55MP0003566_abnormal_cell_adhesion1.31163251
56MP0010155_abnormal_intestine_physiology1.30936729
57MP0000343_altered_response_to1.28172173
58MP0004185_abnormal_adipocyte_glucose1.28159273
59MP0001851_eye_inflammation1.27570552
60MP0003300_gastrointestinal_ulcer1.27270352
61MP0004264_abnormal_extraembryonic_tissu1.26819083
62MP0000767_abnormal_smooth_muscle1.25925075
63MP0002932_abnormal_joint_morphology1.24639604
64MP0005165_increased_susceptibility_to1.23165910
65MP0008875_abnormal_xenobiotic_pharmacok1.21958273
66MP0005670_abnormal_white_adipose1.21907470
67MP0005451_abnormal_body_composition1.21728890
68MP0009764_decreased_sensitivity_to1.20927221
69MP0002419_abnormal_innate_immunity1.20871547
70MP0002009_preneoplasia1.20869322
71MP0001765_abnormal_ion_homeostasis1.20625643
72MP0009780_abnormal_chondrocyte_physiolo1.19555896
73MP0004019_abnormal_vitamin_homeostasis1.19304262
74MP0000383_abnormal_hair_follicle1.18737896
75MP0000467_abnormal_esophagus_morphology1.18071370
76MP0005248_abnormal_Harderian_gland1.17866034
77MP0001346_abnormal_lacrimal_gland1.17555255
78MP0001835_abnormal_antigen_presentation1.17309380
79MP0003279_aneurysm1.15353891
80MP0001663_abnormal_digestive_system1.14310739
81MP0004147_increased_porphyrin_level1.13496638
82MP0009840_abnormal_foam_cell1.12708813
83MP0000490_abnormal_crypts_of1.12494829
84MP0004084_abnormal_cardiac_muscle1.12229545
85MP0004043_abnormal_pH_regulation1.11523732
86MP0005365_abnormal_bile_salt1.10346263
87MP0005025_abnormal_response_to1.09897796
88MP0001533_abnormal_skeleton_physiology1.08557710
89MP0010678_abnormal_skin_adnexa1.07902995
90MP0008438_abnormal_cutaneous_collagen1.07706824
91MP0003879_abnormal_hair_cell1.07352963
92MP0005409_darkened_coat_color1.07190561
93MP0005171_absent_coat_pigmentation1.06880360
94MP0000627_abnormal_mammary_gland1.06673907
95MP0005275_abnormal_skin_tensile1.06096338
96MP0003191_abnormal_cellular_cholesterol1.04212178
97MP0000579_abnormal_nail_morphology1.03680910
98MP0001664_abnormal_digestion1.03375381
99MP0003453_abnormal_keratinocyte_physiol1.03100919
100MP0004947_skin_inflammation1.01333039
101MP0001188_hyperpigmentation1.00821435
102MP0002998_abnormal_bone_remodeling1.00462247
103MP0005503_abnormal_tendon_morphology0.98297968
104MP0000470_abnormal_stomach_morphology0.97713417
105MP0009643_abnormal_urine_homeostasis0.96729069
106MP0003303_peritoneal_inflammation0.96508166
107MP0010329_abnormal_lipoprotein_level0.96145146
108MP0005164_abnormal_response_to0.94904059
109MP0002166_altered_tumor_susceptibility0.94514061
110MP0005367_renal/urinary_system_phenotyp0.93832629
111MP0000516_abnormal_urinary_system0.93832629
112MP0000762_abnormal_tongue_morphology0.93331266
113MP0005075_abnormal_melanosome_morpholog0.93185629
114MP0000249_abnormal_blood_vessel0.90567556
115MP0001764_abnormal_homeostasis0.89849020
116MP0005058_abnormal_lysosome_morphology0.89598285
117MP0005310_abnormal_salivary_gland0.89206779
118MP0003183_abnormal_peptide_metabolism0.88101307
119MP0009931_abnormal_skin_appearance0.87662085
120MP0003448_altered_tumor_morphology0.87268784
121MP0003436_decreased_susceptibility_to0.87227187
122MP0001216_abnormal_epidermal_layer0.86739325
123MP0000858_altered_metastatic_potential0.85869987
124MP0001545_abnormal_hematopoietic_system0.84002503
125MP0005397_hematopoietic_system_phenotyp0.84002503
126MP0005501_abnormal_skin_physiology0.83048538
127MP0002970_abnormal_white_adipose0.82008805
128MP0002249_abnormal_larynx_morphology0.81610061
129MP0002896_abnormal_bone_mineralization0.81172641
130MP0005381_digestive/alimentary_phenotyp0.81141435
131MP0005388_respiratory_system_phenotype0.80824174
132MP0002133_abnormal_respiratory_system0.80824174
133MP0010386_abnormal_urinary_bladder0.80459559
134MP0002933_joint_inflammation0.80316485
135MP0000733_abnormal_muscle_development0.79815559
136MP0000377_abnormal_hair_follicle0.79553004
137MP0005330_cardiomyopathy0.78763109
138MP0005174_abnormal_tail_pigmentation0.78476184
139MP0003567_abnormal_fetal_cardiomyocyte0.78465814
140MP0010630_abnormal_cardiac_muscle0.78431268
141MP0005464_abnormal_platelet_physiology0.77912298
142MP0002295_abnormal_pulmonary_circulatio0.76613117
143MP0000477_abnormal_intestine_morphology0.76374944
144MP0005390_skeleton_phenotype0.76224163
145MP0002116_abnormal_craniofacial_bone0.76049720
146MP0001666_abnormal_nutrient_absorption0.75497604
147MP0010771_integument_phenotype0.74320759
148MP0002118_abnormal_lipid_homeostasis0.73906697
149MP0000537_abnormal_urethra_morphology0.73515662
150MP0001845_abnormal_inflammatory_respons0.73146807
151MP0000372_irregular_coat_pigmentation0.72200128
152MP0002089_abnormal_postnatal_growth/wei0.71924037
153MP0003942_abnormal_urinary_system0.71736475
154MP0004883_abnormal_blood_vessel0.70761383
155MP0000681_abnormal_thyroid_gland0.69525865
156MP0003123_paternal_imprinting0.69240565
157MP0005595_abnormal_vascular_smooth0.68692429
158MP0003091_abnormal_cell_migration0.68481726
159MP0004036_abnormal_muscle_relaxation0.63410995
160MP0005508_abnormal_skeleton_morphology0.62653384
161MP0001727_abnormal_embryo_implantation0.62040004
162MP0005023_abnormal_wound_healing0.59190711

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)6.61187798
2J-shaped sella turcica (HP:0002680)5.62229548
3Cervical subluxation (HP:0003308)5.60339063
4Broad face (HP:0000283)5.44209993
5Stridor (HP:0010307)4.83048160
6Right ventricular cardiomyopathy (HP:0011663)4.12523743
7Lymphangioma (HP:0100764)4.02019945
8Vacuolated lymphocytes (HP:0001922)3.73897752
9Aplasia cutis congenita (HP:0001057)3.69845206
10Aortic regurgitation (HP:0001659)3.69732531
11Thin bony cortex (HP:0002753)3.60619339
12Onycholysis (HP:0001806)3.59200324
13Atelectasis (HP:0100750)3.50623160
14Interstitial pulmonary disease (HP:0006530)3.28285419
15Spontaneous hematomas (HP:0007420)3.27114706
16Nuclear cataract (HP:0100018)3.27008782
17Biconcave vertebral bodies (HP:0004586)3.15838244
18Mucopolysacchariduria (HP:0008155)3.13908195
19Urinary glycosaminoglycan excretion (HP:0003541)3.13908195
20Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.11111923
21Abnormality of lateral ventricle (HP:0030047)3.07723047
22Easy fatigability (HP:0003388)3.05243881
23Dysostosis multiplex (HP:0000943)3.04167205
24Abnormality of polysaccharide metabolism (HP:0011012)3.04141733
25Abnormality of glycosaminoglycan metabolism (HP:0004371)3.04141733
26Abnormality of mucopolysaccharide metabolism (HP:0011020)3.04141733
27Patchy hypopigmentation of hair (HP:0011365)3.02043140
28Joint stiffness (HP:0001387)3.01637234
29Pulmonary artery stenosis (HP:0004415)3.01488657
30Cerebral aneurysm (HP:0004944)3.01151803
31Deformed sella turcica (HP:0002681)3.00053889
32Congenital, generalized hypertrichosis (HP:0004540)2.98076733
33Increased connective tissue (HP:0009025)2.97934493
34Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.96166528
35Delayed CNS myelination (HP:0002188)2.90803867
36Hematochezia (HP:0002573)2.90630621
37Chronic bronchitis (HP:0004469)2.87773355
38Nasal polyposis (HP:0100582)2.86578452
39Flat acetabular roof (HP:0003180)2.83083977
40Facial diplegia (HP:0001349)2.80829074
41Abnormal respiratory motile cilium morphology (HP:0005938)2.77029216
42Abnormal respiratory epithelium morphology (HP:0012253)2.77029216
43Flattened epiphyses (HP:0003071)2.74293170
44Ependymoma (HP:0002888)2.70338785
45Sleep apnea (HP:0010535)2.67763506
46Orchitis (HP:0100796)2.65466538
47Distal upper limb amyotrophy (HP:0007149)2.65380310
48Upper limb amyotrophy (HP:0009129)2.65380310
49Neoplasm of the heart (HP:0100544)2.64360294
50Esophageal varix (HP:0002040)2.63705661
51Severe Myopia (HP:0011003)2.63559154
52Cerebral palsy (HP:0100021)2.63525163
53Prolonged bleeding time (HP:0003010)2.60682171
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.60309863
55Absent/shortened dynein arms (HP:0200106)2.60309863
56Ventricular tachycardia (HP:0004756)2.59688061
57Atrophic scars (HP:0001075)2.58395163
58Abnormal respiratory motile cilium physiology (HP:0012261)2.56152968
59Bronchomalacia (HP:0002780)2.53900835
60Broad metatarsal (HP:0001783)2.53898645
61White forelock (HP:0002211)2.50730552
62Myositis (HP:0100614)2.47767295
63Distal lower limb muscle weakness (HP:0009053)2.47270742
64Abnormal ciliary motility (HP:0012262)2.43259543
65Neurodegeneration (HP:0002180)2.41814608
66Prostate neoplasm (HP:0100787)2.41789851
67Hyperacusis (HP:0010780)2.39872754
68Hypoplasia of the odontoid process (HP:0003311)2.38048748
69Recurrent abscess formation (HP:0002722)2.36921206
70Visceral angiomatosis (HP:0100761)2.32199099
71Eczematoid dermatitis (HP:0000976)2.31654743
72Mitral regurgitation (HP:0001653)2.31615413
73Diaphragmatic weakness (HP:0009113)2.29506536
74Aplasia/hypoplasia of the femur (HP:0005613)2.29395071
75Vitreoretinal degeneration (HP:0000655)2.27853205
76Hypoplasia of the iris (HP:0007676)2.27818161
77Abnormality of secondary sexual hair (HP:0009888)2.26585138
78Abnormality of the axillary hair (HP:0100134)2.26585138
79Milia (HP:0001056)2.24874205
80Mildly elevated creatine phosphokinase (HP:0008180)2.24485464
81Abnormal hemoglobin (HP:0011902)2.22961894
82Flared iliac wings (HP:0002869)2.21716778
83Stomach cancer (HP:0012126)2.16718397
84Nephritis (HP:0000123)2.16651111
85Bulbar palsy (HP:0001283)2.14962993
86Hemangiomatosis (HP:0007461)2.13856780
87Distal lower limb amyotrophy (HP:0008944)2.12902927
88Bell-shaped thorax (HP:0001591)2.12370942
89Weak cry (HP:0001612)2.12343961
90Spinal canal stenosis (HP:0003416)2.11781096
91Abnormal vertebral ossification (HP:0100569)2.11365337
92Ectropion (HP:0000656)2.10751671
93Hypoplasia of dental enamel (HP:0006297)2.10494081
94Hypertriglyceridemia (HP:0002155)2.10438342
95Renal salt wasting (HP:0000127)2.08764452
96Periodontitis (HP:0000704)2.08549375
97Rhinitis (HP:0012384)2.07949454
98Abnormality of the distal phalanges of the toes (HP:0010182)2.07668165
99Portal hypertension (HP:0001409)2.05122168
100Hyperactive renin-angiotensin system (HP:0000841)2.03083252
101Abnormality of the odontoid process (HP:0003310)2.02138833
102Metaphyseal cupping (HP:0003021)2.01645630
103Systemic lupus erythematosus (HP:0002725)2.00763641
104Plantar hyperkeratosis (HP:0007556)2.00272108
105Thrombocytosis (HP:0001894)1.97936063
106Conical tooth (HP:0000698)1.97075758
107Aneurysm (HP:0002617)1.96277859
108Hand muscle atrophy (HP:0009130)1.95931348
109Gout (HP:0001997)1.95631438
110Short clavicles (HP:0000894)1.94854225
111Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.94852405
112Aortic valve stenosis (HP:0001650)1.94129161
113Malnutrition (HP:0004395)1.93948940
114Polycythemia (HP:0001901)1.93373177
115Abnormality of the nasal mucosa (HP:0000433)1.93099583
116Lip pit (HP:0100267)1.92253724
117Tubulointerstitial nephritis (HP:0001970)1.90828483
118Reduced antithrombin III activity (HP:0001976)1.90433991
119Natal tooth (HP:0000695)1.90344823
120Optic neuritis (HP:0100653)1.90139029
121Retrobulbar optic neuritis (HP:0100654)1.90139029
122Congenital ichthyosiform erythroderma (HP:0007431)1.86804312
123Testicular atrophy (HP:0000029)1.85734757
124Shallow orbits (HP:0000586)1.85171169
125Abnormality of the hepatic vasculature (HP:0006707)1.85050962
126Reticulocytopenia (HP:0001896)1.85028704
127Abnormality of the dental pulp (HP:0006479)1.82995960
128Pustule (HP:0200039)1.82541879
129Sparse lateral eyebrow (HP:0005338)1.82294402
130Colitis (HP:0002583)1.81529425
131Abnormality of the femoral head (HP:0003368)1.81286075
132Recurrent bacterial skin infections (HP:0005406)1.80904666
133Corneal erosion (HP:0200020)1.80792523
134Vascular calcification (HP:0004934)1.79770765
135Myopathic facies (HP:0002058)1.79611583
136Abnormality of the sella turcica (HP:0002679)1.78605356
137Renal cortical cysts (HP:0000803)1.78001329
138Abnormality of molar (HP:0011077)1.76883145
139Abnormality of molar morphology (HP:0011070)1.76883145
140Aortic aneurysm (HP:0004942)1.76708312
141Bronchiectasis (HP:0002110)1.76555644
142Aplasia/Hypoplasia of the clavicles (HP:0006710)1.76293947
143Craniofacial hyperostosis (HP:0004493)1.75978210
144Acanthosis nigricans (HP:0000956)1.72462062
145Joint hemorrhage (HP:0005261)1.71877003
146Pili torti (HP:0003777)1.71619296
147Broad nasal tip (HP:0000455)1.71125637
148Premature loss of primary teeth (HP:0006323)1.70723214
149Amelogenesis imperfecta (HP:0000705)1.70309558
150Widely patent fontanelles and sutures (HP:0004492)1.68993591
151Cheilitis (HP:0100825)1.68570352
152Tracheal stenosis (HP:0002777)1.68549414
153Abnormality of the thoracic spine (HP:0100711)1.68181938
154Short nail (HP:0001799)1.68050957
155Hypotrichosis (HP:0001006)1.67864827
156Flat capital femoral epiphysis (HP:0003370)1.67290684
157Generalized amyotrophy (HP:0003700)1.67018046
158Alveolar cell carcinoma (HP:0006519)1.66196473
159Abnormality of macrophages (HP:0004311)1.65906965
160Short hallux (HP:0010109)1.65773403
161Increased IgE level (HP:0003212)1.65396412
162Adactyly (HP:0009776)1.65205860
163Bundle branch block (HP:0011710)1.65066089
164Hypoproteinemia (HP:0003075)1.64833783
165Microcytic anemia (HP:0001935)1.64764774
166Nonimmune hydrops fetalis (HP:0001790)1.64242975
167Premature skin wrinkling (HP:0100678)1.63348534
168Emphysema (HP:0002097)1.63310841
169Pulmonary hypertension (HP:0002092)1.62190904
170Hemorrhage of the eye (HP:0011885)1.61847002
171Abnormality of renal resorption (HP:0011038)1.60141306
172Fragile nails (HP:0001808)1.59984494
173Cardiovascular calcification (HP:0011915)1.59971945
174Woolly hair (HP:0002224)1.59541442
175Type I transferrin isoform profile (HP:0003642)1.59153880
176Advanced eruption of teeth (HP:0006288)1.58107469
177Congenital sensorineural hearing impairment (HP:0008527)1.57555579
178Abnormality of primary teeth (HP:0006481)1.57160587
179Abnormality of permanent molar morphology (HP:0011071)1.56113415
180Abnormality of the dental root (HP:0006486)1.56113415
181Taurodontia (HP:0000679)1.56113415
182Menorrhagia (HP:0000132)1.55138773
183Germ cell neoplasia (HP:0100728)1.54718323
184IgM deficiency (HP:0002850)1.53821323
185Petechiae (HP:0000967)1.53398241
186Polar cataract (HP:0010696)1.52798526
187Thick nail (HP:0001805)1.52318592
188Epistaxis (HP:0000421)1.51881671
189Nasolacrimal duct obstruction (HP:0000579)1.51250069
190Curly hair (HP:0002212)1.50410669

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE16.31798761
2TRIB35.05222312
3TGFBR23.18410652
4TNK22.87270403
5IRAK32.56881716
6PKN22.41133056
7TESK12.34046339
8PIK3CA2.31582114
9EPHA22.23476756
10SIK12.15961224
11SMG12.10990116
12KDR2.09292363
13IRAK42.06673589
14MAP3K62.02911901
15GRK12.00846519
16MST1R1.85567837
17ICK1.85491295
18ERN11.85460534
19EEF2K1.85133236
20TGFBR11.81715581
21MARK21.78877762
22MYLK1.76427206
23EPHB21.75199842
24NME21.74021694
25ERBB21.70900618
26BMPR1B1.69189533
27MAP3K31.68982081
28BMX1.64090096
29MAP2K21.62595347
30MAP3K141.62378188
31CAMK1D1.57621823
32MST41.55054181
33FGFR41.54785686
34MAP2K31.50569934
35EPHB11.47536899
36NLK1.41556779
37ZAK1.40206532
38TEC1.38298604
39RPS6KA21.38242436
40EPHA31.37310091
41BLK1.36400908
42MATK1.33449166
43MAPK151.33418018
44MAP3K71.31650210
45PTK61.29599802
46FER1.26894100
47TRPM71.24368235
48MAP3K111.16727274
49LMTK21.12298171
50PRKCI1.08640736
51PTK21.05741240
52IRAK11.03515977
53RPS6KB21.02216925
54JAK31.01887898
55STK241.01476459
56MTOR1.00478696
57TAOK10.98984586
58EIF2AK20.98116737
59HIPK20.96535029
60CDC42BPA0.96507107
61LATS10.96191564
62CAMK1G0.93979291
63TNIK0.92813375
64STK390.89171435
65PRKD30.88990778
66INSRR0.88704152
67IKBKE0.87941937
68MAP4K10.87464064
69TAOK30.83475704
70JAK10.81104946
71CASK0.81028764
72TYK20.80385773
73GRK70.78862902
74IKBKB0.76781892
75AKT30.75873841
76RIPK10.74855078
77BTK0.73025357
78FGFR30.71236428
79ADRBK20.70157759
80ZAP700.69648758
81NUAK10.68861920
82KIT0.68314048
83MUSK0.67888274
84CSK0.67352455
85PRKG20.66017864
86STK38L0.65374140
87CDK120.64777258
88CHUK0.64580677
89CDK30.63969844
90PAK40.62739401
91TBK10.61852117
92MAPKAPK30.60633211
93PRKAA20.60620937
94STK160.58298757
95PIK3CG0.58230129
96MAP2K60.56359088
97STK380.56028859
98TXK0.55995251
99SIK30.55659281
100FRK0.55642676
101GRK60.54722596
102NEK90.53947218
103MKNK20.53607061
104TTN0.53159545
105PRKCE0.52781580
106PRKD20.51985313
107NME10.50864274
108DYRK1B0.50293365
109NTRK30.50007964
110MAP3K10.49856526
111PDGFRB0.49189694
112PRKD10.48794447
113PDPK10.48526749
114BMPR20.47884680
115MAPK80.47686817
116PRKAA10.47371463
117LRRK20.47294163
118MAPK120.47024786
119ILK0.46123767
120STK30.44747980
121DMPK0.44607108
122MAPKAPK20.44242587
123CAMK10.44146864
124CDK90.44132243
125BCKDK0.43591757
126PDGFRA0.42078294
127PIM20.41913828
128RPS6KL10.41321744
129RPS6KC10.41321744
130JAK20.40287697
131YES10.40051020
132MET0.39940708
133MAP3K130.38736675
134IGF1R0.38690945
135MAP2K10.38632917
136RIPK40.38059450
137RPS6KA60.37181872
138CDK70.36858358
139CLK10.36379247
140MAPK70.35029565
141NEK60.34947030
142SIK20.34079240
143RPS6KA10.33680512
144MAPK30.33191383
145RET0.31116537
146ROCK10.29650186
147MAPK40.28772578
148MAPK10.27996497
149MAP3K100.27811237
150DDR20.25843365
151TESK20.24512677
152SRC0.23646234
153PTK2B0.23189641
154CAMKK10.22542645

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004604.09725016
2Caffeine metabolism_Homo sapiens_hsa002323.02458003
3Other glycan degradation_Homo sapiens_hsa005112.46746794
4Phenylalanine metabolism_Homo sapiens_hsa003602.35689948
5Fructose and mannose metabolism_Homo sapiens_hsa000512.28005307
6Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.22675308
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.05463820
8Glycerophospholipid metabolism_Homo sapiens_hsa005642.04766858
9Arachidonic acid metabolism_Homo sapiens_hsa005902.03155078
10Sulfur relay system_Homo sapiens_hsa041221.92074229
11Malaria_Homo sapiens_hsa051441.79374008
12Fatty acid biosynthesis_Homo sapiens_hsa000611.76106631
13ECM-receptor interaction_Homo sapiens_hsa045121.68609481
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.67923982
15Leishmaniasis_Homo sapiens_hsa051401.65610357
16Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.65065383
17Pertussis_Homo sapiens_hsa051331.61748144
18Glycerolipid metabolism_Homo sapiens_hsa005611.54055246
19Sphingolipid metabolism_Homo sapiens_hsa006001.53747510
20Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.49528257
21Toll-like receptor signaling pathway_Homo sapiens_hsa046201.46688044
22Leukocyte transendothelial migration_Homo sapiens_hsa046701.46588682
23Rheumatoid arthritis_Homo sapiens_hsa053231.43847427
24Toxoplasmosis_Homo sapiens_hsa051451.41065939
25Glycosaminoglycan degradation_Homo sapiens_hsa005311.40140758
26AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40010015
27Longevity regulating pathway - mammal_Homo sapiens_hsa042111.38551822
28Tyrosine metabolism_Homo sapiens_hsa003501.36999607
29AMPK signaling pathway_Homo sapiens_hsa041521.33887023
30Protein digestion and absorption_Homo sapiens_hsa049741.33648772
31Choline metabolism in cancer_Homo sapiens_hsa052311.32823967
32NF-kappa B signaling pathway_Homo sapiens_hsa040641.32592452
33Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.32184877
34Insulin resistance_Homo sapiens_hsa049311.30710998
35Staphylococcus aureus infection_Homo sapiens_hsa051501.29429170
36Vitamin digestion and absorption_Homo sapiens_hsa049771.28790252
37alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.26422940
38Insulin signaling pathway_Homo sapiens_hsa049101.25272007
39Lysosome_Homo sapiens_hsa041421.24434203
40Hematopoietic cell lineage_Homo sapiens_hsa046401.22612582
41Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.21349159
42VEGF signaling pathway_Homo sapiens_hsa043701.18578982
43Osteoclast differentiation_Homo sapiens_hsa043801.18444779
44mTOR signaling pathway_Homo sapiens_hsa041501.16749735
45Intestinal immune network for IgA production_Homo sapiens_hsa046721.16428716
46Linoleic acid metabolism_Homo sapiens_hsa005911.16093201
47TNF signaling pathway_Homo sapiens_hsa046681.12898148
48Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.12417092
49Arginine biosynthesis_Homo sapiens_hsa002201.12400969
50NOD-like receptor signaling pathway_Homo sapiens_hsa046211.11531944
51Hepatitis C_Homo sapiens_hsa051601.07650999
52Jak-STAT signaling pathway_Homo sapiens_hsa046301.07494683
53Phospholipase D signaling pathway_Homo sapiens_hsa040721.06384782
54RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.05061145
55Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04931002
56Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.04333918
57Notch signaling pathway_Homo sapiens_hsa043301.04146621
58Pentose and glucuronate interconversions_Homo sapiens_hsa000401.04073504
59Adherens junction_Homo sapiens_hsa045201.03728247
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.03497750
61Prolactin signaling pathway_Homo sapiens_hsa049171.02220246
62Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.01993068
63Mineral absorption_Homo sapiens_hsa049781.01310158
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98596158
65Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.98376171
66Axon guidance_Homo sapiens_hsa043600.98319361
67Lysine degradation_Homo sapiens_hsa003100.95280704
68Measles_Homo sapiens_hsa051620.93786353
69Amoebiasis_Homo sapiens_hsa051460.93112449
70Galactose metabolism_Homo sapiens_hsa000520.92182057
71Transcriptional misregulation in cancer_Homo sapiens_hsa052020.91789657
72Ether lipid metabolism_Homo sapiens_hsa005650.90524280
73Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.90113348
74Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.90081239
75Influenza A_Homo sapiens_hsa051640.89784337
76Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.88476620
77Platelet activation_Homo sapiens_hsa046110.88114905
78Chronic myeloid leukemia_Homo sapiens_hsa052200.87939804
79Focal adhesion_Homo sapiens_hsa045100.87890171
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.87276296
81Pancreatic secretion_Homo sapiens_hsa049720.86368013
82Ribosome_Homo sapiens_hsa030100.86089856
83Retinol metabolism_Homo sapiens_hsa008300.82603919
84Small cell lung cancer_Homo sapiens_hsa052220.82105079
85Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81651105
86GnRH signaling pathway_Homo sapiens_hsa049120.79854284
87Salmonella infection_Homo sapiens_hsa051320.78163497
88Adipocytokine signaling pathway_Homo sapiens_hsa049200.77494201
89Estrogen signaling pathway_Homo sapiens_hsa049150.76132505
90Chemical carcinogenesis_Homo sapiens_hsa052040.75720572
91ABC transporters_Homo sapiens_hsa020100.75384555
92Bile secretion_Homo sapiens_hsa049760.74485488
93Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.73883144
94Bladder cancer_Homo sapiens_hsa052190.73881746
95Histidine metabolism_Homo sapiens_hsa003400.73505160
96Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.73058709
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.72927608
98Legionellosis_Homo sapiens_hsa051340.72288457
99beta-Alanine metabolism_Homo sapiens_hsa004100.72271928
100Arginine and proline metabolism_Homo sapiens_hsa003300.70899519
101Tuberculosis_Homo sapiens_hsa051520.70650910
102Renin-angiotensin system_Homo sapiens_hsa046140.69840719
103Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.68803003
104Phagosome_Homo sapiens_hsa041450.68659610
105Fatty acid elongation_Homo sapiens_hsa000620.68086782
106Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.67376500
107Phosphatidylinositol signaling system_Homo sapiens_hsa040700.66671766
108Acute myeloid leukemia_Homo sapiens_hsa052210.66422924
109African trypanosomiasis_Homo sapiens_hsa051430.66063372
110Tight junction_Homo sapiens_hsa045300.65456493
111ErbB signaling pathway_Homo sapiens_hsa040120.64997799
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.63142782
113Endocytosis_Homo sapiens_hsa041440.63132144
114TGF-beta signaling pathway_Homo sapiens_hsa043500.62946017
115Pathways in cancer_Homo sapiens_hsa052000.62922604
116SNARE interactions in vesicular transport_Homo sapiens_hsa041300.62688682
117Pentose phosphate pathway_Homo sapiens_hsa000300.62387617
118Herpes simplex infection_Homo sapiens_hsa051680.60092599
119Central carbon metabolism in cancer_Homo sapiens_hsa052300.59998658
120Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59521897
121Apoptosis_Homo sapiens_hsa042100.59200306
122Ovarian steroidogenesis_Homo sapiens_hsa049130.58928016
123Endometrial cancer_Homo sapiens_hsa052130.58509558
124PI3K-Akt signaling pathway_Homo sapiens_hsa041510.57867018
125Complement and coagulation cascades_Homo sapiens_hsa046100.57334487
126Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.56986947
127Sulfur metabolism_Homo sapiens_hsa009200.56326017
128Inositol phosphate metabolism_Homo sapiens_hsa005620.55084335
129Vascular smooth muscle contraction_Homo sapiens_hsa042700.54578005
130Glutathione metabolism_Homo sapiens_hsa004800.53835583
131Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.52574908
132Pancreatic cancer_Homo sapiens_hsa052120.52147420
133PPAR signaling pathway_Homo sapiens_hsa033200.52039279
134Fatty acid degradation_Homo sapiens_hsa000710.51252384
135Vibrio cholerae infection_Homo sapiens_hsa051100.51111434
136Fat digestion and absorption_Homo sapiens_hsa049750.51078838
137Starch and sucrose metabolism_Homo sapiens_hsa005000.50559451
138Collecting duct acid secretion_Homo sapiens_hsa049660.50423278
139Protein export_Homo sapiens_hsa030600.50190021
140Rap1 signaling pathway_Homo sapiens_hsa040150.49222536
141Glucagon signaling pathway_Homo sapiens_hsa049220.49141029
142N-Glycan biosynthesis_Homo sapiens_hsa005100.48313318
143Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45471882
144Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.43823437
145Melanoma_Homo sapiens_hsa052180.43560056
146Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.43503085
147Non-small cell lung cancer_Homo sapiens_hsa052230.43002594
148Carbohydrate digestion and absorption_Homo sapiens_hsa049730.42890045
149Fatty acid metabolism_Homo sapiens_hsa012120.41998473
150Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41908096
151Drug metabolism - other enzymes_Homo sapiens_hsa009830.41019323
152Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.40427422
153Thyroid cancer_Homo sapiens_hsa052160.40185192
154Neurotrophin signaling pathway_Homo sapiens_hsa047220.40175654
155Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.35864700
156Biosynthesis of amino acids_Homo sapiens_hsa012300.35744759
157Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.33927346

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