CRADD

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein containing a death domain (DD) motif. This protein recruits caspase 2/ICH1 to the cell death signal transduction complex, which includes tumor necrosis factor receptor 1 (TNFR1A) and RIPK1/RIP kinase, and acts in promoting apoptosis. A mutation in this gene was associated with mental retardation. A related pseudogene is found on chromosome 3. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)6.33156526
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.46911476
3ATP synthesis coupled proton transport (GO:0015986)5.46911476
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.30761246
5polyketide metabolic process (GO:0030638)5.28569764
6doxorubicin metabolic process (GO:0044598)5.28569764
7daunorubicin metabolic process (GO:0044597)5.28569764
8respiratory electron transport chain (GO:0022904)4.99824717
9electron transport chain (GO:0022900)4.96194729
10protein neddylation (GO:0045116)4.46200972
11tryptophan catabolic process (GO:0006569)3.92971680
12indole-containing compound catabolic process (GO:0042436)3.92971680
13indolalkylamine catabolic process (GO:0046218)3.92971680
14establishment of protein localization to mitochondrial membrane (GO:0090151)3.91086976
15chaperone-mediated protein transport (GO:0072321)3.88175456
16cullin deneddylation (GO:0010388)3.86926417
17regulation of cellular amino acid metabolic process (GO:0006521)3.79847261
18NAD biosynthetic process (GO:0009435)3.75616873
19negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.66363766
20L-phenylalanine metabolic process (GO:0006558)3.61203885
21erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.61203885
22tryptophan metabolic process (GO:0006568)3.61108901
23regulation of cilium movement (GO:0003352)3.54210476
24indolalkylamine metabolic process (GO:0006586)3.54043181
25positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.53750026
26* DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.52458603
27aromatic amino acid family catabolic process (GO:0009074)3.51030025
28protein deneddylation (GO:0000338)3.50992488
29hydrogen ion transmembrane transport (GO:1902600)3.50587562
30ATP biosynthetic process (GO:0006754)3.38786016
31* signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.37761706
32* signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.37761706
33* signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.37761706
34* intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.37709492
35* signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.37709492
36G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)3.36152486
37purine nucleoside triphosphate biosynthetic process (GO:0009145)3.34573863
38nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32475827
39aminoglycoside antibiotic metabolic process (GO:0030647)3.32464725
40proton transport (GO:0015992)3.32411997
41purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.30417040
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.30310479
43hydrogen transport (GO:0006818)3.29149584
44S-adenosylmethionine metabolic process (GO:0046500)3.26311774
45negative regulation of ligase activity (GO:0051352)3.25925028
46negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.25925028
47DNA deamination (GO:0045006)3.23904101
48* signal transduction involved in DNA integrity checkpoint (GO:0072401)3.22424780
49* signal transduction involved in DNA damage checkpoint (GO:0072422)3.22424780
50* signal transduction involved in cell cycle checkpoint (GO:0072395)3.21222637
51mitochondrial respiratory chain complex I assembly (GO:0032981)3.20048138
52NADH dehydrogenase complex assembly (GO:0010257)3.20048138
53mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.20048138
54L-phenylalanine catabolic process (GO:0006559)3.17491418
55erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.17491418
56positive regulation of TOR signaling (GO:0032008)3.17391420
57rRNA modification (GO:0000154)3.16323033
58exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.15823825
59signal peptide processing (GO:0006465)3.15107706
60positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.14172355
61inner mitochondrial membrane organization (GO:0007007)3.13799972
62protein complex biogenesis (GO:0070271)3.12811853
63adenosine metabolic process (GO:0046085)3.12419601
64platelet dense granule organization (GO:0060155)3.10963701
65positive regulation of ligase activity (GO:0051351)3.09892859
66positive regulation of mitochondrial fission (GO:0090141)3.09497988
67xenobiotic catabolic process (GO:0042178)3.05545461
68anterograde synaptic vesicle transport (GO:0048490)3.04263777
69water-soluble vitamin biosynthetic process (GO:0042364)3.04175012
70GTP biosynthetic process (GO:0006183)3.03915282
71amine catabolic process (GO:0009310)3.01796681
72cellular biogenic amine catabolic process (GO:0042402)3.01796681
73endosome to melanosome transport (GO:0035646)2.98914020
74endosome to pigment granule transport (GO:0043485)2.98914020
75protein targeting to mitochondrion (GO:0006626)2.97548885
76cellular ketone body metabolic process (GO:0046950)2.97084923
77ubiquinone biosynthetic process (GO:0006744)2.92973080
78quinone biosynthetic process (GO:1901663)2.92973080
79sequestering of actin monomers (GO:0042989)2.92523254
80iron-sulfur cluster assembly (GO:0016226)2.91973177
81metallo-sulfur cluster assembly (GO:0031163)2.91973177
82anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.91649393
83L-methionine salvage (GO:0071267)2.91098098
84L-methionine biosynthetic process (GO:0071265)2.91098098
85amino acid salvage (GO:0043102)2.91098098
86regulation of mitochondrial translation (GO:0070129)2.89875166
87establishment of protein localization to mitochondrion (GO:0072655)2.87641088
88mitochondrial respiratory chain complex assembly (GO:0033108)2.87019214
89tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.84407617
90RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.84407617
91pyridine nucleotide biosynthetic process (GO:0019363)2.84272407
92nicotinamide nucleotide biosynthetic process (GO:0019359)2.84272407
93protein localization to mitochondrion (GO:0070585)2.83920835
94mitochondrial transport (GO:0006839)2.83785516
95respiratory chain complex IV assembly (GO:0008535)2.83676499
96imidazole-containing compound metabolic process (GO:0052803)2.83493252
97aromatic amino acid family metabolic process (GO:0009072)2.81947957
98energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.80766140
99ATP hydrolysis coupled proton transport (GO:0015991)2.80766140
100trivalent inorganic anion homeostasis (GO:0072506)2.80307887
101phosphate ion homeostasis (GO:0055062)2.80307887
102aldehyde catabolic process (GO:0046185)2.79383602
103mannosylation (GO:0097502)2.78501898
104negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.78458785
105L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.77547099
106positive regulation of growth hormone secretion (GO:0060124)2.77015670
107maturation of SSU-rRNA (GO:0030490)2.76748904
108ribonucleoside triphosphate biosynthetic process (GO:0009201)2.76478127
109aerobic respiration (GO:0009060)2.73117100
110kynurenine metabolic process (GO:0070189)2.73074136
111intracellular protein transmembrane import (GO:0044743)2.72860927
112superoxide anion generation (GO:0042554)2.72389121
113GPI anchor metabolic process (GO:0006505)2.72361041
114preassembly of GPI anchor in ER membrane (GO:0016254)2.72289592
115response to nitrosative stress (GO:0051409)2.72111039
116coenzyme catabolic process (GO:0009109)2.71966562
117kinetochore assembly (GO:0051382)2.71519044
118regulation of cellular amine metabolic process (GO:0033238)2.71357451
119C-terminal protein lipidation (GO:0006501)2.71181851
120GPI anchor biosynthetic process (GO:0006506)2.70605999
121oxidative phosphorylation (GO:0006119)2.69646304
122C-terminal protein amino acid modification (GO:0018410)2.69479396
123branched-chain amino acid metabolic process (GO:0009081)2.69391463
124quinone metabolic process (GO:1901661)2.67794912
125proteasome assembly (GO:0043248)2.67654945
126antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.66426499
127bile acid biosynthetic process (GO:0006699)2.66238636
128ubiquinone metabolic process (GO:0006743)2.61896274
129regulation of interleukin-8 secretion (GO:2000482)2.61865681
130pteridine-containing compound biosynthetic process (GO:0042559)2.60897081
131cofactor catabolic process (GO:0051187)2.57453102
132detection of molecule of bacterial origin (GO:0032490)2.57167882
133cellular anion homeostasis (GO:0030002)2.52186281
134energy homeostasis (GO:0097009)2.51853036
135cytochrome complex assembly (GO:0017004)2.50212921
136positive regulation of T cell mediated cytotoxicity (GO:0001916)2.48758283
137indole-containing compound metabolic process (GO:0042430)2.48523196
138omega-hydroxylase P450 pathway (GO:0097267)2.48080937
139positive regulation of uterine smooth muscle contraction (GO:0070474)2.46158248
140ribosomal small subunit assembly (GO:0000028)2.44252079
141cellular respiration (GO:0045333)2.44142659
142glycoside metabolic process (GO:0016137)2.44083335
143proline biosynthetic process (GO:0006561)2.41734511
144proline metabolic process (GO:0006560)2.40897096
145phenylpropanoid metabolic process (GO:0009698)2.40088726
146cell differentiation involved in metanephros development (GO:0072202)2.39583415
147NAD metabolic process (GO:0019674)2.38456576
148alkaloid metabolic process (GO:0009820)2.38321454
149branched-chain amino acid catabolic process (GO:0009083)2.37412669
150urea cycle (GO:0000050)2.36581544
151urea metabolic process (GO:0019627)2.36581544
152detection of other organism (GO:0098543)2.35750359
153transcription elongation from RNA polymerase III promoter (GO:0006385)2.33293296
154termination of RNA polymerase III transcription (GO:0006386)2.33293296
155low-density lipoprotein particle remodeling (GO:0034374)2.33002813
156purinergic nucleotide receptor signaling pathway (GO:0035590)2.31699009
157bile acid and bile salt transport (GO:0015721)2.31675186
158dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.31160708
159blood coagulation, intrinsic pathway (GO:0007597)2.30300498
160glyoxylate metabolic process (GO:0046487)2.30271684
161positive regulation of gamma-delta T cell activation (GO:0046645)2.29954472
162positive regulation of antigen processing and presentation (GO:0002579)2.29954040
163DNA dealkylation (GO:0035510)2.29889957
164negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.29739582
165nitrogen cycle metabolic process (GO:0071941)2.28150526
166detection of external biotic stimulus (GO:0098581)2.27218109
167positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.27029231
168fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.26884945
169regulation of glucokinase activity (GO:0033131)2.25318703
170regulation of hexokinase activity (GO:1903299)2.25318703
171benzene-containing compound metabolic process (GO:0042537)2.24100047
172detection of bacterium (GO:0016045)2.22899925
173cellular glucuronidation (GO:0052695)2.20851407
174glucuronate metabolic process (GO:0019585)2.19410228
175uronic acid metabolic process (GO:0006063)2.19410228

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EGR1_23403033_ChIP-Seq_LIVER_Mouse4.00014158
2ELF1_17652178_ChIP-ChIP_JURKAT_Human3.94635356
3FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.77118233
4CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.65631769
5IRF8_22096565_ChIP-ChIP_GC-B_Human3.52278119
6* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.18297340
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.16370378
8IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.16212948
9BP1_19119308_ChIP-ChIP_Hs578T_Human3.10599098
10CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.03787998
11SRF_21415370_ChIP-Seq_HL-1_Mouse2.94175154
12* ETS1_20019798_ChIP-Seq_JURKAT_Human2.69403548
13RBPJ_22232070_ChIP-Seq_NCS_Mouse2.67884435
14JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.60951526
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.47151710
16E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.47094742
17SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.44030525
18* RXR_22158963_ChIP-Seq_LIVER_Mouse2.42902880
19HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.41645156
20FLI1_20887958_ChIP-Seq_HPC-7_Mouse2.33042562
21NOTCH1_21737748_ChIP-Seq_TLL_Human2.24701246
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.24488954
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.23079360
24LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.18997529
25ZNF274_21170338_ChIP-Seq_K562_Hela2.08606848
26* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.08375180
27GABP_17652178_ChIP-ChIP_JURKAT_Human2.05644956
28TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.00270430
29FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.97791804
30VDR_22108803_ChIP-Seq_LS180_Human1.88479290
31PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.87902282
32IRF8_21731497_ChIP-ChIP_J774_Mouse1.82105864
33FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.79256100
34* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.74557508
35* FOXP3_21729870_ChIP-Seq_TREG_Human1.73922969
36* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.73100784
37PCGF2_27294783_Chip-Seq_ESCs_Mouse1.72171838
38* EST1_17652178_ChIP-ChIP_JURKAT_Human1.69485675
39* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.68490671
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.68447831
41POU3F2_20337985_ChIP-ChIP_501MEL_Human1.67135486
42HOXB4_20404135_ChIP-ChIP_EML_Mouse1.65585518
43* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.60559209
44NFE2_27457419_Chip-Seq_LIVER_Mouse1.60262715
45FUS_26573619_Chip-Seq_HEK293_Human1.60165109
46SCL_19346495_ChIP-Seq_HPC-7_Human1.57715936
47MYC_18555785_ChIP-Seq_MESCs_Mouse1.53908566
48MYC_18358816_ChIP-ChIP_MESCs_Mouse1.51938009
49SUZ12_27294783_Chip-Seq_NPCs_Mouse1.51859088
50PADI4_21655091_ChIP-ChIP_MCF-7_Human1.51241612
51HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.49910429
52YY1_21170310_ChIP-Seq_MESCs_Mouse1.49358186
53STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.49156387
54* EZH2_27294783_Chip-Seq_NPCs_Mouse1.47414909
55TP63_19390658_ChIP-ChIP_HaCaT_Human1.46372722
56ERG_20887958_ChIP-Seq_HPC-7_Mouse1.44465027
57EWS_26573619_Chip-Seq_HEK293_Human1.43892311
58* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.43424747
59* VDR_23849224_ChIP-Seq_CD4+_Human1.42216108
60* LXR_22158963_ChIP-Seq_LIVER_Mouse1.41397794
61CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.40851428
62FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.40593374
63ELK1_22589737_ChIP-Seq_MCF10A_Human1.38282684
64GABP_19822575_ChIP-Seq_HepG2_Human1.33513942
65STAT4_19710469_ChIP-ChIP_TH1__Mouse1.31758250
66* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.31690665
67EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30982984
68TP53_22573176_ChIP-Seq_HFKS_Human1.30382180
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.29782065
70MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.29102446
71* TTF2_22483619_ChIP-Seq_HELA_Human1.28922525
72GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28742642
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.28684387
74PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.28440368
75PCGF2_27294783_Chip-Seq_NPCs_Mouse1.27867484
76ZFP57_27257070_Chip-Seq_ESCs_Mouse1.26955903
77TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25991355
78IRF1_19129219_ChIP-ChIP_H3396_Human1.25798785
79AR_20517297_ChIP-Seq_VCAP_Human1.24810964
80SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.22400168
81* P300_19829295_ChIP-Seq_ESCs_Human1.21889049
82NANOG_19829295_ChIP-Seq_ESCs_Human1.20424321
83SOX2_19829295_ChIP-Seq_ESCs_Human1.20424321
84CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.19128627
85MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.18083196
86E2F7_22180533_ChIP-Seq_HELA_Human1.17562375
87CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17191383
88FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.17023554
89STAT3_18555785_Chip-Seq_ESCs_Mouse1.16673645
90THAP11_20581084_ChIP-Seq_MESCs_Mouse1.15904873
91XRN2_22483619_ChIP-Seq_HELA_Human1.15454461
92DCP1A_22483619_ChIP-Seq_HELA_Human1.14066586
93EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.13661600
94RUNX1_27457419_Chip-Seq_LIVER_Mouse1.13426127
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12974491
96SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12703406
97CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12522116
98* ELK1_19687146_ChIP-ChIP_HELA_Human1.11865630
99HTT_18923047_ChIP-ChIP_STHdh_Human1.11177090
100* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.11016226
101MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.10402211
102* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.09680795
103* CRX_20693478_ChIP-Seq_RETINA_Mouse1.08577938
104HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.08405749
105ZFX_18555785_Chip-Seq_ESCs_Mouse1.08078454
106NMYC_18555785_Chip-Seq_ESCs_Mouse1.08011420
107ERG_20517297_ChIP-Seq_VCAP_Human1.06865938
108* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06474589
109* SPI1_23547873_ChIP-Seq_NB4_Human1.05699861
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.04493285
111* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03216933
112KAP1_22055183_ChIP-Seq_ESCs_Mouse1.02894820
113P53_22387025_ChIP-Seq_ESCs_Mouse1.02265577
114GATA1_22025678_ChIP-Seq_K562_Human1.00066474
115* IRF8_27001747_Chip-Seq_BMDM_Mouse0.99726852
116CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.99409562
117EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.99409414
118POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.98981791
119ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98652152
120SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98318694
121EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.98017175
122OCT4_18555785_Chip-Seq_ESCs_Mouse0.97555882
123* SALL4_22934838_ChIP-ChIP_CD34+_Human0.97516835
124IGF1R_20145208_ChIP-Seq_DFB_Human0.96116714
125MYC_18940864_ChIP-ChIP_HL60_Human0.95471450
126PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.95411230
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.95384789
128PU1_27457419_Chip-Seq_LIVER_Mouse0.95077853
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.94351436
130FOXA1_25329375_ChIP-Seq_VCAP_Human0.94152536
131FOXA1_27270436_Chip-Seq_PROSTATE_Human0.94152536
132* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.94069146
133CTBP1_25329375_ChIP-Seq_LNCAP_Human0.94052202
134* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.93969667
135MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.93702723
136AUTS2_25519132_ChIP-Seq_293T-REX_Human0.93379299
137P300_18555785_Chip-Seq_ESCs_Mouse0.93197149
138E2F1_18555785_Chip-Seq_ESCs_Mouse0.92474792
139* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.92250822
140ER_23166858_ChIP-Seq_MCF-7_Human0.92065193
141PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.90521274
142FOXA1_21572438_ChIP-Seq_LNCaP_Human0.89700894
143NELFA_20434984_ChIP-Seq_ESCs_Mouse0.87599702
144* NCOR_22424771_ChIP-Seq_293T_Human0.87273191
145PHF8_20622853_ChIP-Seq_HELA_Human0.86493833
146GATA3_21878914_ChIP-Seq_MCF-7_Human0.82024954
147ETV2_25802403_ChIP-Seq_MESCs_Mouse0.80079283
148EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.79516322
149KLF5_20875108_ChIP-Seq_MESCs_Mouse0.79438817
150GATA6_21074721_ChIP-Seq_CACO-2_Human0.78911568

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system4.17814938
2MP0005085_abnormal_gallbladder_physiolo3.52879296
3MP0002837_dystrophic_cardiac_calcinosis3.38220663
4MP0003011_delayed_dark_adaptation3.25392401
5MP0005365_abnormal_bile_salt3.13260698
6MP0002138_abnormal_hepatobiliary_system3.10125370
7MP0006072_abnormal_retinal_apoptosis3.00790100
8MP0006292_abnormal_olfactory_placode2.75874537
9MP0003195_calcinosis2.73147932
10MP0001986_abnormal_taste_sensitivity2.66487540
11MP0000569_abnormal_digit_pigmentation2.62722632
12MP0002132_abnormal_respiratory_system2.61369310
13MP0001529_abnormal_vocalization2.59834833
14MP0003806_abnormal_nucleotide_metabolis2.50090527
15MP0009697_abnormal_copulation2.41022850
16MP0001188_hyperpigmentation2.34967083
17MP0005360_urolithiasis2.30316139
18MP0009379_abnormal_foot_pigmentation2.29640319
19MP0005671_abnormal_response_to2.29120939
20MP0008875_abnormal_xenobiotic_pharmacok2.15989058
21MP0001835_abnormal_antigen_presentation2.10423354
22MP0002148_abnormal_hypersensitivity_rea2.06961531
23MP0004782_abnormal_surfactant_physiolog2.01727908
24MP0006035_abnormal_mitochondrial_morpho1.98746132
25MP0005075_abnormal_melanosome_morpholog1.95295559
26MP0004145_abnormal_muscle_electrophysio1.91209907
27MP0003718_maternal_effect1.90645576
28MP0001984_abnormal_olfaction1.89246736
29MP0003186_abnormal_redox_activity1.88412653
30MP0000015_abnormal_ear_pigmentation1.81124092
31MP0009785_altered_susceptibility_to1.80737185
32MP0002277_abnormal_respiratory_mucosa1.79060159
33MP0005253_abnormal_eye_physiology1.76577743
34MP0003252_abnormal_bile_duct1.75874082
35MP0002163_abnormal_gland_morphology1.73546134
36MP0001764_abnormal_homeostasis1.71057357
37MP0003136_yellow_coat_color1.64131270
38MP0005174_abnormal_tail_pigmentation1.59517551
39MP0005636_abnormal_mineral_homeostasis1.59393533
40MP0009780_abnormal_chondrocyte_physiolo1.58349521
41MP0003191_abnormal_cellular_cholesterol1.55106886
42MP0003724_increased_susceptibility_to1.52953052
43MP0008789_abnormal_olfactory_epithelium1.50380732
44MP0002909_abnormal_adrenal_gland1.47600195
45MP0005084_abnormal_gallbladder_morpholo1.47242168
46MP0009840_abnormal_foam_cell1.46327460
47MP0005367_renal/urinary_system_phenotyp1.44010037
48MP0000516_abnormal_urinary_system1.44010037
49MP0003868_abnormal_feces_composition1.38685186
50MP0000749_muscle_degeneration1.37735853
51MP0000566_synostosis1.37302451
52MP0000372_irregular_coat_pigmentation1.37241028
53MP0004142_abnormal_muscle_tone1.32471953
54MP0008058_abnormal_DNA_repair1.30965905
55MP0000613_abnormal_salivary_gland1.30202961
56MP0002332_abnormal_exercise_endurance1.29441934
57MP0005503_abnormal_tendon_morphology1.28702151
58MP0008995_early_reproductive_senescence1.27111044
59MP0005083_abnormal_biliary_tract1.26962865
60MP0001905_abnormal_dopamine_level1.26492083
61MP0003763_abnormal_thymus_physiology1.26387188
62MP0005645_abnormal_hypothalamus_physiol1.26148708
63MP0002876_abnormal_thyroid_physiology1.25751001
64MP0005025_abnormal_response_to1.25737326
65MP0002102_abnormal_ear_morphology1.24815130
66MP0005171_absent_coat_pigmentation1.24380627
67MP0005551_abnormal_eye_electrophysiolog1.24271352
68MP0006276_abnormal_autonomic_nervous1.22691377
69MP0005266_abnormal_metabolism1.21653381
70MP0006082_CNS_inflammation1.21530380
71MP0001800_abnormal_humoral_immune1.20488985
72MP0009333_abnormal_splenocyte_physiolog1.18343141
73MP0008775_abnormal_heart_ventricle1.18088562
74MP0010386_abnormal_urinary_bladder1.15254601
75MP0000685_abnormal_immune_system1.13861785
76MP0005410_abnormal_fertilization1.13399807
77MP0002638_abnormal_pupillary_reflex1.11665321
78MP0001666_abnormal_nutrient_absorption1.10935876
79MP0000678_abnormal_parathyroid_gland1.10926680
80MP0005332_abnormal_amino_acid1.10414529
81MP0005379_endocrine/exocrine_gland_phen1.09157824
82MP0004019_abnormal_vitamin_homeostasis1.08102936
83MP0008004_abnormal_stomach_pH1.07971992
84MP0002938_white_spotting1.06898209
85MP0008872_abnormal_physiological_respon1.06795210
86MP0006036_abnormal_mitochondrial_physio1.05516238
87MP0004084_abnormal_cardiac_muscle1.05338880
88MP0003941_abnormal_skin_development1.04907012
89MP0005387_immune_system_phenotype1.04718057
90MP0001790_abnormal_immune_system1.04718057
91MP0004215_abnormal_myocardial_fiber1.04643428
92MP0001727_abnormal_embryo_implantation1.02679149
93MP0005670_abnormal_white_adipose1.01148256
94MP0002090_abnormal_vision1.00542716
95MP0002405_respiratory_system_inflammati1.00532267
96MP0003880_abnormal_central_pattern0.99770011
97MP0001293_anophthalmia0.99233706
98MP0000631_abnormal_neuroendocrine_gland0.98653337
99MP0002452_abnormal_antigen_presenting0.98566448
100MP0002693_abnormal_pancreas_physiology0.97860029
101MP0002723_abnormal_immune_serum0.97788388
102MP0005319_abnormal_enzyme/_coenzyme0.97745405
103MP0002396_abnormal_hematopoietic_system0.97288907
104MP0003436_decreased_susceptibility_to0.97201848
105MP0009764_decreased_sensitivity_to0.97101568
106MP0002420_abnormal_adaptive_immunity0.97082697
107MP0001845_abnormal_inflammatory_respons0.96591132
108MP0001819_abnormal_immune_cell0.96581645
109MP0005499_abnormal_olfactory_system0.96064494
110MP0005394_taste/olfaction_phenotype0.96064494
111MP0008469_abnormal_protein_level0.95933646
112MP0003656_abnormal_erythrocyte_physiolo0.95727793
113MP0002419_abnormal_innate_immunity0.95597710
114MP0003786_premature_aging0.94822467
115MP0000681_abnormal_thyroid_gland0.94570367
116MP0002095_abnormal_skin_pigmentation0.93911398
117MP0004147_increased_porphyrin_level0.93801941
118MP0001661_extended_life_span0.93392912
119MP0005535_abnormal_body_temperature0.93050153
120MP0008877_abnormal_DNA_methylation0.91544346
121MP0002822_catalepsy0.90503387
122MP0009046_muscle_twitch0.89808192
123MP0004381_abnormal_hair_follicle0.87006905
124MP0000490_abnormal_crypts_of0.86903828
125MP0000716_abnormal_immune_system0.84366651
126MP0002751_abnormal_autonomic_nervous0.83922821
127MP0004133_heterotaxia0.83650740
128MP0005187_abnormal_penis_morphology0.83443804
129MP0010030_abnormal_orbit_morphology0.83393132
130MP0005000_abnormal_immune_tolerance0.83192899
131MP0005646_abnormal_pituitary_gland0.83164807
132MP0000013_abnormal_adipose_tissue0.82956486
133MP0005248_abnormal_Harderian_gland0.82745456
134MP0005647_abnormal_sex_gland0.81080547
135MP0010155_abnormal_intestine_physiology0.81058029
136MP0002234_abnormal_pharynx_morphology0.80812780
137MP0001756_abnormal_urination0.80242150
138MP0001186_pigmentation_phenotype0.79430228
139MP0005310_abnormal_salivary_gland0.79332024
140MP0002933_joint_inflammation0.79268507
141MP0005220_abnormal_exocrine_pancreas0.79101186
142MP0001944_abnormal_pancreas_morphology0.79076771
143MP0001485_abnormal_pinna_reflex0.78628513
144MP0002928_abnormal_bile_duct0.77794649
145MP0009765_abnormal_xenobiotic_induced0.76364709
146MP0000609_abnormal_liver_physiology0.76025867
147MP0008007_abnormal_cellular_replicative0.75943923
148MP0000689_abnormal_spleen_morphology0.75870413
149MP0002398_abnormal_bone_marrow0.75297301
150MP0005464_abnormal_platelet_physiology0.74602390
151MP0002078_abnormal_glucose_homeostasis0.74224418
152MP0000639_abnormal_adrenal_gland0.74011392
153MP0005376_homeostasis/metabolism_phenot0.73501700
154MP0010329_abnormal_lipoprotein_level0.73228025
155MP0005389_reproductive_system_phenotype0.72638397
156MP0003646_muscle_fatigue0.72598702

Predicted human phenotypes

RankGene SetZ-score
1Reduced antithrombin III activity (HP:0001976)3.98900883
2Type I transferrin isoform profile (HP:0003642)3.65340333
3Hypothermia (HP:0002045)3.64109385
4Abnormality of aromatic amino acid family metabolism (HP:0004338)3.41828880
5Microvesicular hepatic steatosis (HP:0001414)3.30561913
6Abnormality of pyrimidine metabolism (HP:0004353)3.25726175
7Conjugated hyperbilirubinemia (HP:0002908)3.25470551
8Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.21173779
9Decreased activity of mitochondrial respiratory chain (HP:0008972)3.21173779
10Congenital, generalized hypertrichosis (HP:0004540)3.06801781
11Prolonged partial thromboplastin time (HP:0003645)3.06347770
12Respiratory failure (HP:0002878)3.04406300
13Medial flaring of the eyebrow (HP:0010747)3.00074843
14Methylmalonic acidemia (HP:0002912)2.99621906
15Hepatic necrosis (HP:0002605)2.96196070
16Methylmalonic aciduria (HP:0012120)2.87469571
17Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84082461
18Hepatocellular necrosis (HP:0001404)2.75158388
19Abnormality of monocarboxylic acid metabolism (HP:0010996)2.67966353
20Abnormal protein glycosylation (HP:0012346)2.66461224
21Abnormal glycosylation (HP:0012345)2.66461224
22Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.66461224
23Abnormal protein N-linked glycosylation (HP:0012347)2.66461224
24Joint hemorrhage (HP:0005261)2.63643712
25Increased serum lactate (HP:0002151)2.61642886
26Optic disc pallor (HP:0000543)2.57959740
27Ketoacidosis (HP:0001993)2.56474923
28Mitochondrial inheritance (HP:0001427)2.55231344
29Chromsome breakage (HP:0040012)2.51347806
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50408747
31Abnormality of alanine metabolism (HP:0010916)2.50408747
32Hyperalaninemia (HP:0003348)2.50408747
33Hyperinsulinemic hypoglycemia (HP:0000825)2.49607864
34Lipid accumulation in hepatocytes (HP:0006561)2.46930955
35Increased CSF lactate (HP:0002490)2.45736836
36Abnormal mitochondria in muscle tissue (HP:0008316)2.44083562
37Congenital primary aphakia (HP:0007707)2.44074055
38Generalized aminoaciduria (HP:0002909)2.42678280
39Abnormality of renal resorption (HP:0011038)2.41748584
40Nausea (HP:0002018)2.41053003
41Renal cortical cysts (HP:0000803)2.40920279
42Acute necrotizing encephalopathy (HP:0006965)2.39515644
43Thyroid-stimulating hormone excess (HP:0002925)2.39370020
44Increased hepatocellular lipid droplets (HP:0006565)2.39266434
45Intrahepatic cholestasis (HP:0001406)2.37404522
46Lactic acidosis (HP:0003128)2.34934924
47Myoglobinuria (HP:0002913)2.33010794
48Gait imbalance (HP:0002141)2.32469244
49Abnormal number of erythroid precursors (HP:0012131)2.32210931
50Acute encephalopathy (HP:0006846)2.31090980
51Cerebral edema (HP:0002181)2.31012082
52Delayed CNS myelination (HP:0002188)2.30258285
53Aplastic anemia (HP:0001915)2.30208658
54Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.29281849
55Abnormality of vitamin B metabolism (HP:0004340)2.24542309
56CNS demyelination (HP:0007305)2.22952496
573-Methylglutaconic aciduria (HP:0003535)2.20753014
58Nephrogenic diabetes insipidus (HP:0009806)2.20605120
59Exertional dyspnea (HP:0002875)2.19343607
60Hyperphosphaturia (HP:0003109)2.18904034
61Patchy hypopigmentation of hair (HP:0011365)2.17631873
62Abnormality of serum amino acid levels (HP:0003112)2.16686104
63Renal Fanconi syndrome (HP:0001994)2.15917451
64Ketosis (HP:0001946)2.15543150
65Albinism (HP:0001022)2.14890480
66Hyperglycemia (HP:0003074)2.14474802
67Increased IgM level (HP:0003496)2.12326570
68Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.11395428
69Increased serum pyruvate (HP:0003542)2.09952785
70Increased intramyocellular lipid droplets (HP:0012240)2.09155777
71Osteomalacia (HP:0002749)2.07959092
72Lethargy (HP:0001254)2.07345957
73Palpitations (HP:0001962)2.06081410
74Aplasia/Hypoplasia of the fovea (HP:0008060)2.04740072
75Hypoplasia of the fovea (HP:0007750)2.04740072
76True hermaphroditism (HP:0010459)2.03643330
77Leukodystrophy (HP:0002415)2.02762961
78Hyperbilirubinemia (HP:0002904)2.02011528
79Increased muscle lipid content (HP:0009058)2.01500058
80Molar tooth sign on MRI (HP:0002419)2.00469653
81Abnormality of midbrain morphology (HP:0002418)2.00469653
82Abnormal pupillary function (HP:0007686)1.99495301
83Abnormality of methionine metabolism (HP:0010901)1.99150629
84Chronic hepatic failure (HP:0100626)1.99021736
85Tubulointerstitial nephritis (HP:0001970)1.97976482
86White forelock (HP:0002211)1.97780540
87Hypoglycemic seizures (HP:0002173)1.97018104
88Abnormal hair whorl (HP:0010721)1.96842609
89Metabolic acidosis (HP:0001942)1.96499218
90Opisthotonus (HP:0002179)1.95717476
91Respiratory difficulties (HP:0002880)1.94260032
92Glycosuria (HP:0003076)1.93339650
93Abnormality of urine glucose concentration (HP:0011016)1.93339650
94Systemic lupus erythematosus (HP:0002725)1.92892187
95Abnormality of fatty-acid metabolism (HP:0004359)1.92773668
96Hypergonadotropic hypogonadism (HP:0000815)1.92575530
97Hyperglycinemia (HP:0002154)1.91700376
98Abnormality of the vitamin B12 metabolism (HP:0004341)1.90745119
99Glomerulonephritis (HP:0000099)1.90402741
100Prolonged neonatal jaundice (HP:0006579)1.90302957
101Abnormality of cells of the erythroid lineage (HP:0012130)1.88954135
102Intestinal atresia (HP:0011100)1.88510981
103Calf muscle hypertrophy (HP:0008981)1.87755314
104Abnormality of dicarboxylic acid metabolism (HP:0010995)1.87370171
105Dicarboxylic aciduria (HP:0003215)1.87370171
106Optic neuritis (HP:0100653)1.87341448
107Retrobulbar optic neuritis (HP:0100654)1.87341448
108Renal tubular dysfunction (HP:0000124)1.86473119
109Neonatal hypoglycemia (HP:0001998)1.86313212
110Muscle hypertrophy of the lower extremities (HP:0008968)1.84981845
111Hypoglycemic coma (HP:0001325)1.84683244
112Abnormality of serine family amino acid metabolism (HP:0010894)1.83705497
113Abnormality of glycine metabolism (HP:0010895)1.83705497
114Myositis (HP:0100614)1.83143505
115Emotional lability (HP:0000712)1.81416494
116Alveolar cell carcinoma (HP:0006519)1.80963459
117Hyperammonemia (HP:0001987)1.80734319
118Cheilitis (HP:0100825)1.80523306
119Type 2 muscle fiber atrophy (HP:0003554)1.79748054
120Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.79732196
121Oral leukoplakia (HP:0002745)1.79694672
122Conjunctival hamartoma (HP:0100780)1.79684492
123Pancreatic cysts (HP:0001737)1.79457022
124Sclerocornea (HP:0000647)1.77365294
125Dry hair (HP:0011359)1.77315649
126Orchitis (HP:0100796)1.77262767
127Exercise intolerance (HP:0003546)1.77056092
128Cerebral palsy (HP:0100021)1.76727074
129Progressive macrocephaly (HP:0004481)1.76449594
130Absent rod-and cone-mediated responses on ERG (HP:0007688)1.75845502
131Muscle fiber atrophy (HP:0100295)1.74915241
132Pancytopenia (HP:0001876)1.74271569
133Abnormality of aspartate family amino acid metabolism (HP:0010899)1.74164564
134Vaginal atresia (HP:0000148)1.74097175
135Prolonged bleeding time (HP:0003010)1.72696624
136Pancreatic fibrosis (HP:0100732)1.72684060
137Recurrent cutaneous fungal infections (HP:0011370)1.72667016
138Chronic mucocutaneous candidiasis (HP:0002728)1.72667016
139Abnormality of the renal cortex (HP:0011035)1.72484945
140Abnormality of the intrinsic pathway (HP:0010989)1.72351258
141Exercise-induced muscle cramps (HP:0003710)1.71905141
142Nephronophthisis (HP:0000090)1.71599216
143Genital tract atresia (HP:0001827)1.71428442
144Severe visual impairment (HP:0001141)1.71211273
145Abnormality of glutamine family amino acid metabolism (HP:0010902)1.70887958
146Vascular calcification (HP:0004934)1.70467597
147Furrowed tongue (HP:0000221)1.68451477
148Vomiting (HP:0002013)1.68072245
149X-linked dominant inheritance (HP:0001423)1.67421675

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK3.45960738
2VRK23.22164917
3ZAK3.02519958
4IRAK32.89892945
5STK162.79606143
6TXK2.76868242
7MST42.70469555
8PHKG12.46139254
9PHKG22.46139254
10PRPF4B2.43104334
11BCKDK2.35873293
12SIK32.30199403
13TRIM282.19633753
14EIF2AK12.17008362
15IRAK42.11403340
16CASK2.09830168
17NUAK12.06658975
18EIF2AK31.99595798
19NLK1.95042534
20ADRBK21.94927157
21AKT31.94330119
22MAP3K141.93418059
23BUB11.86619933
24TLK11.85324967
25VRK11.82891056
26BLK1.82527590
27NME21.78012257
28BMPR1B1.75620154
29TEC1.71491755
30NEK91.69067189
31NEK11.68666523
32MAP4K21.64084027
33IKBKB1.62718084
34CDK81.58188046
35FLT31.57635383
36IKBKE1.55377762
37YES11.54846527
38TAOK21.53464448
39TNIK1.53347342
40TIE11.46648456
41TESK21.43707403
42PIM21.40979725
43ERBB31.38729987
44DYRK21.38294084
45PLK31.32809863
46BRSK21.32499110
47TNK21.31282154
48CSNK1G11.29177965
49CSNK1G31.26649480
50ZAP701.24509628
51MYLK1.23148112
52INSRR1.22307933
53LIMK11.21693118
54EPHA31.19807088
55BCR1.19613765
56ACVR1B1.18768448
57EIF2AK21.17464683
58GRK71.15645932
59MAP3K121.15539741
60STK41.13299865
61CHUK1.12041923
62PBK1.09752598
63MAP4K11.08132217
64TAOK31.07704082
65PIM11.06952904
66KIT1.06931119
67STK38L1.04707705
68CSNK1G21.04517341
69RPS6KA51.01946375
70IRAK11.01857776
71MAP2K61.01676598
72SGK21.01427454
73PAK31.00989140
74FGFR20.98757154
75CDK190.96184695
76MAPK150.95438106
77CSNK1A1L0.95312734
78FGFR40.95031008
79MAP3K110.93952258
80RIPK40.93273031
81PLK20.93152756
82BMPR20.92647255
83PINK10.92250307
84TYK20.92205800
85SRPK10.90580826
86MAP3K40.90008076
87DYRK30.88990448
88TGFBR20.87959613
89CCNB10.86527359
90OBSCN0.84448321
91GRK10.82713031
92PDK20.81442207
93MAPK110.76812408
94TRPM70.76293429
95CDK70.76251584
96RPS6KA40.73893770
97NME10.71500345
98TBK10.70869338
99PTK2B0.70398641
100LYN0.69738161
101MKNK20.68577518
102PRKCE0.67284214
103SYK0.66634236
104MKNK10.66378999
105TTK0.65483079
106CAMKK20.64772659
107IRAK20.63065609
108MAPKAPK30.60992404
109MATK0.60740987
110JAK10.60446429
111RPS6KB20.60426171
112MUSK0.58633738
113PIK3CG0.58072919
114ABL20.57757235
115PLK10.55993165
116EPHA20.55923254
117PRKAA20.55921770
118FER0.55409421
119DAPK30.54106385
120TESK10.53421224
121NEK60.53021680
122MAPK70.50494153
123BTK0.50363094
124KDR0.49588428
125WNK30.48955844
126ADRBK10.48884018
127PRKCI0.48826085
128BRAF0.46804012
129PRKACA0.46141869
130JAK30.46100358
131CSNK2A10.45806237
132PLK40.44898944
133CAMK2D0.44308200
134MAP2K70.43922413
135ATR0.43878888
136SGK4940.43716464
137SGK2230.43716464
138CAMK40.43604851
139RPS6KA60.43187785
140MAPK40.43186748
141CSNK1A10.42982425
142MAPK30.41572785
143MARK30.41037631
144CSNK2A20.39995252
145TAF10.39941666
146MAP3K130.39059886
147LRRK20.39006313
148STK240.38884982
149LCK0.38612488
150SGK30.36962182
151MAPK130.36762071
152PAK10.34557415
153PRKCG0.32362214
154ILK0.32030756
155WNK40.31144346
156CAMK2A0.30260424
157PRKACB0.29155820

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030602.41504876
2Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007602.33491244
3Pentose and glucuronate interconversions_Homo sapiens_hsa000402.30678120
4Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.25839783
5Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.23576085
6Folate biosynthesis_Homo sapiens_hsa007902.13050225
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.03802816
8Tryptophan metabolism_Homo sapiens_hsa003802.02644400
9Sulfur relay system_Homo sapiens_hsa041222.01652528
10Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.97662429
11Peroxisome_Homo sapiens_hsa041461.95005949
12Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.86241807
13Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.84487260
14Steroid hormone biosynthesis_Homo sapiens_hsa001401.81901855
15Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.81157833
16Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.78661505
17Caffeine metabolism_Homo sapiens_hsa002321.78328010
18Sulfur metabolism_Homo sapiens_hsa009201.77073324
19Maturity onset diabetes of the young_Homo sapiens_hsa049501.73164418
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.68567631
21One carbon pool by folate_Homo sapiens_hsa006701.65609265
22Chemical carcinogenesis_Homo sapiens_hsa052041.65296501
23Cardiac muscle contraction_Homo sapiens_hsa042601.64225832
24Histidine metabolism_Homo sapiens_hsa003401.62745638
25Drug metabolism - other enzymes_Homo sapiens_hsa009831.59828102
26Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.57347602
27Base excision repair_Homo sapiens_hsa034101.53288707
28Retinol metabolism_Homo sapiens_hsa008301.53051823
29beta-Alanine metabolism_Homo sapiens_hsa004101.45429386
30Collecting duct acid secretion_Homo sapiens_hsa049661.44732262
31Intestinal immune network for IgA production_Homo sapiens_hsa046721.42059544
32Ribosome_Homo sapiens_hsa030101.41868770
33Homologous recombination_Homo sapiens_hsa034401.40233243
34Parkinsons disease_Homo sapiens_hsa050121.36112803
35Oxidative phosphorylation_Homo sapiens_hsa001901.35846307
36Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.35694815
37Fatty acid elongation_Homo sapiens_hsa000621.34666366
38Mismatch repair_Homo sapiens_hsa034301.33154630
39RNA polymerase_Homo sapiens_hsa030201.32587404
40Staphylococcus aureus infection_Homo sapiens_hsa051501.30088363
41Phenylalanine metabolism_Homo sapiens_hsa003601.28171198
42Primary immunodeficiency_Homo sapiens_hsa053401.26910803
43Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.26006815
44Complement and coagulation cascades_Homo sapiens_hsa046101.23294373
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.23242954
46Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.20809741
47Starch and sucrose metabolism_Homo sapiens_hsa005001.20462413
48Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.19198041
49Fanconi anemia pathway_Homo sapiens_hsa034601.18007424
50Fatty acid degradation_Homo sapiens_hsa000711.17496956
51DNA replication_Homo sapiens_hsa030301.15223102
52Propanoate metabolism_Homo sapiens_hsa006401.15214376
53Selenocompound metabolism_Homo sapiens_hsa004501.14215342
54Pyrimidine metabolism_Homo sapiens_hsa002401.12240296
55Allograft rejection_Homo sapiens_hsa053301.10522361
56Proteasome_Homo sapiens_hsa030501.09735012
57Tyrosine metabolism_Homo sapiens_hsa003501.06828775
58Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.06770048
59NF-kappa B signaling pathway_Homo sapiens_hsa040641.02845993
60Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.99739164
61Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.97176955
62Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95622411
63Non-homologous end-joining_Homo sapiens_hsa034500.95180733
64Arachidonic acid metabolism_Homo sapiens_hsa005900.93885340
65ABC transporters_Homo sapiens_hsa020100.93530858
66Glutathione metabolism_Homo sapiens_hsa004800.92217996
67Galactose metabolism_Homo sapiens_hsa000520.91385479
68Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.90203050
69Arginine and proline metabolism_Homo sapiens_hsa003300.88491255
70Measles_Homo sapiens_hsa051620.85206320
71Asthma_Homo sapiens_hsa053100.83677272
72Arginine biosynthesis_Homo sapiens_hsa002200.81578523
73Basal transcription factors_Homo sapiens_hsa030220.81557556
74Nitrogen metabolism_Homo sapiens_hsa009100.81272333
75Cysteine and methionine metabolism_Homo sapiens_hsa002700.81173654
76Steroid biosynthesis_Homo sapiens_hsa001000.80809596
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.79978699
78Fat digestion and absorption_Homo sapiens_hsa049750.79830820
79Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78206966
80Huntingtons disease_Homo sapiens_hsa050160.78027884
81Other glycan degradation_Homo sapiens_hsa005110.77037313
82Metabolic pathways_Homo sapiens_hsa011000.76419854
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.74159175
84Linoleic acid metabolism_Homo sapiens_hsa005910.73646644
85Herpes simplex infection_Homo sapiens_hsa051680.70663410
86Type I diabetes mellitus_Homo sapiens_hsa049400.70306576
87Autoimmune thyroid disease_Homo sapiens_hsa053200.69940588
88Purine metabolism_Homo sapiens_hsa002300.66278821
89Systemic lupus erythematosus_Homo sapiens_hsa053220.65199026
90Butanoate metabolism_Homo sapiens_hsa006500.64886774
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63643122
92Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.63313458
93Rheumatoid arthritis_Homo sapiens_hsa053230.61422869
94Vitamin digestion and absorption_Homo sapiens_hsa049770.60581984
95Nucleotide excision repair_Homo sapiens_hsa034200.60523658
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60266581
97Phototransduction_Homo sapiens_hsa047440.53673549
98RNA degradation_Homo sapiens_hsa030180.53417701
99Regulation of autophagy_Homo sapiens_hsa041400.53338121
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.52505722
101Alzheimers disease_Homo sapiens_hsa050100.52179587
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.52101636
103Pyruvate metabolism_Homo sapiens_hsa006200.52041478
1042-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.52012945
105Legionellosis_Homo sapiens_hsa051340.50771403
106Fatty acid metabolism_Homo sapiens_hsa012120.50534093
107Graft-versus-host disease_Homo sapiens_hsa053320.50241257
108Fructose and mannose metabolism_Homo sapiens_hsa000510.49786947
109Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.49604372
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49549661
111Biosynthesis of amino acids_Homo sapiens_hsa012300.49087657
112Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.45486302
113Carbon metabolism_Homo sapiens_hsa012000.43426315
114Jak-STAT signaling pathway_Homo sapiens_hsa046300.43079657
115Hematopoietic cell lineage_Homo sapiens_hsa046400.42536746
116Cyanoamino acid metabolism_Homo sapiens_hsa004600.42206118
117RNA transport_Homo sapiens_hsa030130.41043873
118Leishmaniasis_Homo sapiens_hsa051400.40442920
119Pentose phosphate pathway_Homo sapiens_hsa000300.39567085
120Spliceosome_Homo sapiens_hsa030400.36824064
121Mineral absorption_Homo sapiens_hsa049780.35955129
122Vibrio cholerae infection_Homo sapiens_hsa051100.30846569

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