CRAMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of erythrocyte differentiation (GO:0045647)4.83936439
2histone H3-K36 demethylation (GO:0070544)4.55608920
3mannose metabolic process (GO:0006013)4.12102684
4regulation of histone H3-K27 methylation (GO:0061085)3.96994491
5regulation of NFAT protein import into nucleus (GO:0051532)3.84568733
6histone lysine demethylation (GO:0070076)3.66569421
7histone H3-K9 demethylation (GO:0033169)3.61136388
8positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr3.60483720
9histone demethylation (GO:0016577)3.50576474
103-UTR-mediated mRNA stabilization (GO:0070935)3.44129328
11adherens junction assembly (GO:0034333)3.34465797
12planar cell polarity pathway involved in neural tube closure (GO:0090179)3.28687733
13response to muramyl dipeptide (GO:0032495)3.26627886
14cell-substrate adherens junction assembly (GO:0007045)3.24248714
15focal adhesion assembly (GO:0048041)3.24248714
16regulation of ARF GTPase activity (GO:0032312)3.19581753
17negative regulation of histone methylation (GO:0031061)3.16249987
18intracellular estrogen receptor signaling pathway (GO:0030520)3.12226256
19regulation of RNA export from nucleus (GO:0046831)3.10880630
20regulation of nucleobase-containing compound transport (GO:0032239)3.08787853
21positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003603.08435160
22histone H4 deacetylation (GO:0070933)3.08238963
23negative regulation of cell size (GO:0045792)3.05041205
24protein dealkylation (GO:0008214)3.04011462
25protein demethylation (GO:0006482)3.04011462
26regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.03040319
27cytoskeletal anchoring at plasma membrane (GO:0007016)3.00106584
28apoptotic process involved in morphogenesis (GO:0060561)2.97772639
29regulation of chromatin binding (GO:0035561)2.94077957
30cell-cell junction maintenance (GO:0045217)2.92455324
31RNA stabilization (GO:0043489)2.90783369
32mRNA stabilization (GO:0048255)2.90783369
33embryonic process involved in female pregnancy (GO:0060136)2.89399260
34nucleosome disassembly (GO:0006337)2.89156559
35protein-DNA complex disassembly (GO:0032986)2.89156559
36insulin-like growth factor receptor signaling pathway (GO:0048009)2.88767343
37spliceosomal tri-snRNP complex assembly (GO:0000244)2.88468528
38positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.82858175
39regulation of ARF protein signal transduction (GO:0032012)2.78312137
40heterochromatin organization (GO:0070828)2.76305475
41epithelial cell differentiation involved in prostate gland development (GO:0060742)2.74165534
42activation of Rac GTPase activity (GO:0032863)2.73718619
43negative regulation of granulocyte differentiation (GO:0030853)2.70940287
44thymic T cell selection (GO:0045061)2.69735454
45response to laminar fluid shear stress (GO:0034616)2.69316873
46cellular response to epidermal growth factor stimulus (GO:0071364)2.68899991
47stress granule assembly (GO:0034063)2.67212256
48cell-substrate junction assembly (GO:0007044)2.66129631
49semaphorin-plexin signaling pathway (GO:0071526)2.66033557
50peptidyl-lysine dimethylation (GO:0018027)2.64620757
51histone H3 deacetylation (GO:0070932)2.63913909
52negative regulation of myotube differentiation (GO:0010832)2.63187404
53histone H3-K4 trimethylation (GO:0080182)2.61784261
54positive regulation of myotube differentiation (GO:0010831)2.60809679
55histone H3-K9 modification (GO:0061647)2.60480633
56embryonic camera-type eye morphogenesis (GO:0048596)2.59920970
57embryonic eye morphogenesis (GO:0048048)2.56570720
58positive regulation of blood vessel endothelial cell migration (GO:0043536)2.56334478
59regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.55095832
60positive thymic T cell selection (GO:0045059)2.51466015
61regulation of glucose import in response to insulin stimulus (GO:2001273)2.50269680
62stress fiber assembly (GO:0043149)2.49887748
63chromosome condensation (GO:0030261)2.48329151
64histone H3-K4 methylation (GO:0051568)2.46433043
65poly(A)+ mRNA export from nucleus (GO:0016973)2.45064380
66response to epidermal growth factor (GO:0070849)2.44525433
67positive regulation of gene expression, epigenetic (GO:0045815)2.43833997
68chromatin silencing (GO:0006342)2.41767368
69positive regulation of gamma-delta T cell activation (GO:0046645)2.39690554
70cell volume homeostasis (GO:0006884)2.38500185
71dosage compensation (GO:0007549)2.38413907
72positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.37703992
73negative regulation of fatty acid transport (GO:2000192)2.37457426
74glucocorticoid receptor signaling pathway (GO:0042921)2.37176695
75regulation of mammary gland epithelial cell proliferation (GO:0033599)2.35694590
76negative regulation of gene expression, epigenetic (GO:0045814)2.34818014
77histone lysine methylation (GO:0034968)2.34788731
78histone deacetylation (GO:0016575)2.33681328
79maternal placenta development (GO:0001893)2.32531561
80eye morphogenesis (GO:0048592)2.30106786
81positive regulation of histone deacetylation (GO:0031065)2.29497192
82atrioventricular valve morphogenesis (GO:0003181)2.28957752
83negative regulation of viral release from host cell (GO:1902187)2.28259835
84nuclear pore complex assembly (GO:0051292)2.27519444
85negative regulation of Ras protein signal transduction (GO:0046580)2.25984357
86trophectodermal cell differentiation (GO:0001829)2.25606108
87activation of MAPKKK activity (GO:0000185)2.23711537
88coronary vasculature morphogenesis (GO:0060977)2.21911083
89histone H3-K9 methylation (GO:0051567)2.20484885
90protein localization to endosome (GO:0036010)2.18959807
91modulation by symbiont of host cellular process (GO:0044068)2.18865686
92T cell selection (GO:0045058)2.17796595
93cell migration in hindbrain (GO:0021535)2.17203945
94regulation of histone methylation (GO:0031060)2.16541903
95cortical actin cytoskeleton organization (GO:0030866)2.16438874
96negative regulation of small GTPase mediated signal transduction (GO:0051058)2.15880813
97definitive hemopoiesis (GO:0060216)2.14878403
98neural tube development (GO:0021915)2.14420455
99activation of JUN kinase activity (GO:0007257)2.14221703
100regulation of lipid kinase activity (GO:0043550)2.13635074

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYC_22102868_ChIP-Seq_BL_Human3.50641623
2EGR1_19374776_ChIP-ChIP_THP-1_Human3.29276540
3STAT6_21828071_ChIP-Seq_BEAS2B_Human3.19377614
4KDM2B_26808549_Chip-Seq_SUP-B15_Human3.12173949
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.11886068
6VDR_21846776_ChIP-Seq_THP-1_Human3.03724517
7KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.89110762
8TCF7_22412390_ChIP-Seq_EML_Mouse2.81296358
9KDM2B_26808549_Chip-Seq_DND41_Human2.72046055
10EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.61234215
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.54053005
12LXR_22292898_ChIP-Seq_THP-1_Human2.52641812
13ELK3_25401928_ChIP-Seq_HUVEC_Human2.39323542
14THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.30268796
15KDM2B_26808549_Chip-Seq_K562_Human2.28045750
16KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.27908278
17TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.09711335
18RACK7_27058665_Chip-Seq_MCF-7_Human2.00979651
19KDM2B_26808549_Chip-Seq_JURKAT_Human1.99804459
20VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.96666064
21ZFP281_18757296_ChIP-ChIP_E14_Mouse1.88193932
22VDR_24763502_ChIP-Seq_THP-1_Human1.86526683
23TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.85018104
24RARG_19884340_ChIP-ChIP_MEFs_Mouse1.76554811
25ESR2_21235772_ChIP-Seq_MCF-7_Human1.70496467
26ZFP281_27345836_Chip-Seq_ESCs_Mouse1.68960749
27EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.67009369
28MAF_26560356_Chip-Seq_TH1_Human1.66095680
29ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.64800929
30WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.60505919
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.60492824
32NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.58024899
33E2F7_22180533_ChIP-Seq_HELA_Human1.57553697
34RUNX1_27514584_Chip-Seq_MCF-7_Human1.55398735
35MAF_26560356_Chip-Seq_TH2_Human1.53916846
36UTX_26944678_Chip-Seq_JUKART_Human1.53145076
37P68_20966046_ChIP-Seq_HELA_Human1.52571804
38SMC4_20622854_ChIP-Seq_HELA_Human1.51839219
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.51136310
40CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50729091
41TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47188814
42CREB1_26743006_Chip-Seq_LNCaP_Human1.46322975
43P300_27058665_Chip-Seq_ZR-75-30cells_Human1.46037609
44DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.45806821
45KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.44422958
46CTCF_27219007_Chip-Seq_ERYTHROID_Human1.43131960
47RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.42756868
48SA1_27219007_Chip-Seq_ERYTHROID_Human1.39096767
49KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.38505593
50CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.35589324
51UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.34995576
52NCOR1_26117541_ChIP-Seq_K562_Human1.34289062
53GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33270634
54ERG_21242973_ChIP-ChIP_JURKAT_Human1.32480115
55DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.29931745
56CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.29214117
57EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.28047478
58NFIB_24661679_ChIP-Seq_LUNG_Mouse1.27950993
59BRD4_27068464_Chip-Seq_AML-cells_Mouse1.27560505
60CLOCK_20551151_ChIP-Seq_293T_Human1.27303227
61RUNX1_22412390_ChIP-Seq_EML_Mouse1.26827720
62TET1_21451524_ChIP-Seq_MESCs_Mouse1.24974991
63TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24075464
64TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22175049
65GATA1_19941827_ChIP-Seq_MEL_Mouse1.20498061
66SCL_19346495_ChIP-Seq_HPC-7_Human1.19240420
67ELF1_20517297_ChIP-Seq_JURKAT_Human1.15538338
68SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.15487616
69ZNF263_19887448_ChIP-Seq_K562_Human1.12657531
70DNAJC2_21179169_ChIP-ChIP_NT2_Human1.11726921
71GATA1_19941826_ChIP-Seq_K562_Human1.08281285
72PKCTHETA_26484144_Chip-Seq_BREAST_Human1.07218392
73FOXM1_23109430_ChIP-Seq_U2OS_Human1.06586577
74UBF1/2_26484160_Chip-Seq_HMECs_Human1.05284102
75TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.04312108
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.03946312
77FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.02984196
78MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02499101
79CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.02407460
80SPI1_23127762_ChIP-Seq_K562_Human1.02261133
81TP53_22127205_ChIP-Seq_IMR90_Human1.02166121
82MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.01466050
83TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.00646289
84ATF3_27146783_Chip-Seq_COLON_Human1.00143878
85KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.99878273
86NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.98659248
87SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.95870385
88SOX9_24532713_ChIP-Seq_HFSC_Mouse0.95274546
89TP63_22573176_ChIP-Seq_HFKS_Human0.94657977
90PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.94144056
91STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.93539387
92BCOR_27268052_Chip-Seq_Bcells_Human0.91973050
93CTCF_27219007_Chip-Seq_Bcells_Human0.91905665
94TFAP2A_17053090_ChIP-ChIP_MCF-7_Human0.90564251
95MYB_21317192_ChIP-Seq_ERMYB_Mouse0.90272544
96SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.90074362
97DROSHA_22980978_ChIP-Seq_HELA_Human0.89185770
98KLF4_18555785_ChIP-Seq_MESCs_Mouse0.88718110
99RARB_27405468_Chip-Seq_BRAIN_Mouse0.88388256
100ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.87630582

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003705_abnormal_hypodermis_morpholog4.30320571
2MP0005076_abnormal_cell_differentiation3.63401831
3MP0009278_abnormal_bone_marrow3.20787074
4MP0005409_darkened_coat_color2.66907442
5MP0001849_ear_inflammation2.63113105
6MP0003172_abnormal_lysosome_physiology2.46338342
7MP0003303_peritoneal_inflammation2.25236895
8MP0002249_abnormal_larynx_morphology2.22871135
9MP0002396_abnormal_hematopoietic_system2.07729145
10MP0003091_abnormal_cell_migration2.05594578
11MP0000678_abnormal_parathyroid_gland2.01369567
12MP0004808_abnormal_hematopoietic_stem1.98239422
13MP0005451_abnormal_body_composition1.97724665
14MP0008260_abnormal_autophagy1.94909687
15MP0004185_abnormal_adipocyte_glucose1.93576163
16MP0003763_abnormal_thymus_physiology1.91289541
17MP0005058_abnormal_lysosome_morphology1.88569455
18MP0002009_preneoplasia1.85629533
19MP0003436_decreased_susceptibility_to1.82188340
20MP0003566_abnormal_cell_adhesion1.72741128
21MP0003453_abnormal_keratinocyte_physiol1.71617333
22MP0001348_abnormal_lacrimal_gland1.67648002
23MP0004233_abnormal_muscle_weight1.61795715
24MP0003300_gastrointestinal_ulcer1.60883300
25MP0000733_abnormal_muscle_development1.57560585
26MP0005397_hematopoietic_system_phenotyp1.54459471
27MP0001545_abnormal_hematopoietic_system1.54459471
28MP0003828_pulmonary_edema1.53723489
29MP0004947_skin_inflammation1.49882381
30MP0005666_abnormal_adipose_tissue1.42893912
31MP0010630_abnormal_cardiac_muscle1.42068215
32MP0000703_abnormal_thymus_morphology1.36622354
33MP0002877_abnormal_melanocyte_morpholog1.36601163
34MP0004858_abnormal_nervous_system1.36576549
35MP0004264_abnormal_extraembryonic_tissu1.31229362
36MP0003279_aneurysm1.26678071
37MP0004381_abnormal_hair_follicle1.23892485
38MP0003115_abnormal_respiratory_system1.21124856
39MP0001730_embryonic_growth_arrest1.18868320
40MP0002089_abnormal_postnatal_growth/wei1.16999791
41MP0009672_abnormal_birth_weight1.13019043
42MP0000767_abnormal_smooth_muscle1.10895674
43MP0005375_adipose_tissue_phenotype1.10648195
44MP0005621_abnormal_cell_physiology1.08773112
45MP0002796_impaired_skin_barrier1.07814894
46MP0002998_abnormal_bone_remodeling1.06563137
47MP0000350_abnormal_cell_proliferation1.06376500
48MP0008057_abnormal_DNA_replication1.05954033
49MP0008438_abnormal_cutaneous_collagen1.05586251
50MP0002925_abnormal_cardiovascular_devel1.04551430
51MP0003191_abnormal_cellular_cholesterol1.01675871
52MP0002398_abnormal_bone_marrow0.98976428
53MP0000759_abnormal_skeletal_muscle0.98968590
54MP0004087_abnormal_muscle_fiber0.98375612
55MP0002086_abnormal_extraembryonic_tissu0.97041081
56MP0001915_intracranial_hemorrhage0.96651230
57MP0001873_stomach_inflammation0.95471073
58MP0003984_embryonic_growth_retardation0.94894196
59MP0001958_emphysema0.93815022
60MP0001672_abnormal_embryogenesis/_devel0.92657810
61MP0005380_embryogenesis_phenotype0.92657810
62MP0000537_abnormal_urethra_morphology0.92301159
63MP0009840_abnormal_foam_cell0.91769025
64MP0000858_altered_metastatic_potential0.91264776
65MP0005023_abnormal_wound_healing0.90556930
66MP0008961_abnormal_basal_metabolism0.88983993
67MP0009115_abnormal_fat_cell0.88567391
68MP0002088_abnormal_embryonic_growth/wei0.87907119
69MP0002080_prenatal_lethality0.86413939
70MP0006138_congestive_heart_failure0.85167429
71MP0010352_gastrointestinal_tract_polyps0.85156583
72MP0000428_abnormal_craniofacial_morphol0.84933958
73MP0004782_abnormal_surfactant_physiolog0.83203686
74MP0009931_abnormal_skin_appearance0.82746185
75MP0003329_amyloid_beta_deposits0.81598416
76MP0002060_abnormal_skin_morphology0.80528929
77MP0004197_abnormal_fetal_growth/weight/0.79788844
78MP0000003_abnormal_adipose_tissue0.77571649
79MP0001614_abnormal_blood_vessel0.77046502
80MP0005501_abnormal_skin_physiology0.76504532
81MP0002722_abnormal_immune_system0.76463330
82MP0002166_altered_tumor_susceptibility0.76436133
83MP0002116_abnormal_craniofacial_bone0.76008874
84MP0002108_abnormal_muscle_morphology0.75965998
85MP0002085_abnormal_embryonic_tissue0.75680966
86MP0003183_abnormal_peptide_metabolism0.74561320
87MP0003077_abnormal_cell_cycle0.74522697
88MP0000566_synostosis0.72619377
89MP0009384_cardiac_valve_regurgitation0.72538453
90MP0004510_myositis0.72373410
91MP0002932_abnormal_joint_morphology0.71238739
92MP0002405_respiratory_system_inflammati0.71228180
93MP0000681_abnormal_thyroid_gland0.69949036
94MP0003942_abnormal_urinary_system0.69537998
95MP0003948_abnormal_gas_homeostasis0.69124319
96MP0002419_abnormal_innate_immunity0.68769505
97MP0002114_abnormal_axial_skeleton0.68709685
98MP0000716_abnormal_immune_system0.68585667
99MP0010368_abnormal_lymphatic_system0.67821669
100MP0010307_abnormal_tumor_latency0.66923732

Predicted human phenotypes

RankGene SetZ-score
1Obstructive sleep apnea (HP:0002870)3.69729014
2Abnormality of the fingertips (HP:0001211)3.44027813
3Broad face (HP:0000283)3.30364704
4Hyperacusis (HP:0010780)3.10250337
5Abnormality of the distal phalanx of the thumb (HP:0009617)2.72492064
6Cerebral aneurysm (HP:0004944)2.58657304
7Thin bony cortex (HP:0002753)2.50573862
8Protrusio acetabuli (HP:0003179)2.44631853
9Long eyelashes (HP:0000527)2.36562120
10Ankyloglossia (HP:0010296)2.34653530
11Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.32037988
12Disproportionate tall stature (HP:0001519)2.31098069
13Shallow orbits (HP:0000586)2.29127497
14Spinal cord lesions (HP:0100561)2.27535056
15Syringomyelia (HP:0003396)2.27535056
16Long palpebral fissure (HP:0000637)2.26526368
17Ulnar bowing (HP:0003031)2.25268882
18Deep palmar crease (HP:0006191)2.24881707
19Flat acetabular roof (HP:0003180)2.22132865
20Dislocated radial head (HP:0003083)2.20199609
21Germ cell neoplasia (HP:0100728)2.18351649
22Distal lower limb amyotrophy (HP:0008944)2.13272439
23Abnormality of the radial head (HP:0003995)2.11413268
24Abnormality of the thoracic spine (HP:0100711)2.10799373
25Mitral regurgitation (HP:0001653)2.08920860
26Turricephaly (HP:0000262)2.08794477
27Patellar dislocation (HP:0002999)2.08345270
28Abnormality of oral frenula (HP:0000190)2.08083516
29Abnormality of the aortic arch (HP:0012303)2.04442823
30Bowel incontinence (HP:0002607)2.02863673
31Heterotopia (HP:0002282)2.00092935
32Pointed chin (HP:0000307)1.99304527
33Abnormality of the columella (HP:0009929)1.99023875
34Dysmetric saccades (HP:0000641)1.98356909
35Increased connective tissue (HP:0009025)1.96652579
36Mitral valve prolapse (HP:0001634)1.94910101
37Abnormality of the phalanges of the hallux (HP:0010057)1.91323911
38Colitis (HP:0002583)1.89952265
39Thin ribs (HP:0000883)1.87950458
40Abnormal large intestine physiology (HP:0012700)1.86999268
41Asymmetry of the thorax (HP:0001555)1.86586000
42Thoracic kyphosis (HP:0002942)1.86560441
43Insomnia (HP:0100785)1.85899170
44Cellulitis (HP:0100658)1.85207253
45Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.83579796
46Aneurysm (HP:0002617)1.83337445
47Cervical subluxation (HP:0003308)1.83099394
48Trigonocephaly (HP:0000243)1.79405094
49Urethral obstruction (HP:0000796)1.79117035
50Metaphyseal cupping (HP:0003021)1.76855986
51Narrow palate (HP:0000189)1.76642864
52Genu recurvatum (HP:0002816)1.75908145
53Macroorchidism (HP:0000053)1.75760459
54Slow saccadic eye movements (HP:0000514)1.74482990
55Segmental peripheral demyelination/remyelination (HP:0003481)1.72388518
56Supernumerary ribs (HP:0005815)1.71763888
57Vertebral arch anomaly (HP:0008438)1.70462906
58Centrally nucleated skeletal muscle fibers (HP:0003687)1.70375759
59High anterior hairline (HP:0009890)1.66459258
60Achilles tendon contracture (HP:0001771)1.65355370
61Broad distal phalanx of finger (HP:0009836)1.65197860
62Fragile skin (HP:0001030)1.64926266
63Annular pancreas (HP:0001734)1.64911596
64Polygenic inheritance (HP:0010982)1.63494313
65Distal upper limb amyotrophy (HP:0007149)1.63066977
66Upper limb amyotrophy (HP:0009129)1.63066977
67Aortic aneurysm (HP:0004942)1.62515867
68Broad thumb (HP:0011304)1.62298801
69Atelectasis (HP:0100750)1.62094920
70Arnold-Chiari malformation (HP:0002308)1.61959811
71Increased variability in muscle fiber diameter (HP:0003557)1.60794530
72Renovascular hypertension (HP:0100817)1.59988601
73Joint laxity (HP:0001388)1.59472790
74Lower limb amyotrophy (HP:0007210)1.58923891
75Dilatation of the ascending aorta (HP:0005111)1.57882045
76Abnormality of the calcaneus (HP:0008364)1.57699898
77Premature rupture of membranes (HP:0001788)1.57686753
78Difficulty climbing stairs (HP:0003551)1.57500248
79Sparse lateral eyebrow (HP:0005338)1.56946824
80Atrophic scars (HP:0001075)1.56872245
81Broad metatarsal (HP:0001783)1.56677063
82Bronchomalacia (HP:0002780)1.56597338
83Truncus arteriosus (HP:0001660)1.55411991
84Reticulocytosis (HP:0001923)1.55399837
85Persistence of primary teeth (HP:0006335)1.54370250
86Abnormality of the humeroradial joint (HP:0100744)1.54363186
87Deformed sella turcica (HP:0002681)1.53988839
88Precocious puberty (HP:0000826)1.53554065
89Stereotypic behavior (HP:0000733)1.53298867
90Broad palm (HP:0001169)1.52616252
91Seborrheic dermatitis (HP:0001051)1.52376683
92Cubitus valgus (HP:0002967)1.52209509
93Broad phalanges of the hand (HP:0009768)1.51966834
94Cerebral inclusion bodies (HP:0100314)1.49664671
95Easy fatigability (HP:0003388)1.49611994
96Asymmetric septal hypertrophy (HP:0001670)1.49422461
97Onion bulb formation (HP:0003383)1.49027631
98Advanced eruption of teeth (HP:0006288)1.48450184
99Premature skin wrinkling (HP:0100678)1.47939902
100Broad finger (HP:0001500)1.47813847

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.70993987
2CDK124.01263622
3PRPF4B3.49583900
4EEF2K3.33059386
5ICK3.22983093
6SMG12.76437708
7MAP3K102.62686376
8SIK12.50608221
9RIPK12.25466446
10FGFR41.83560377
11TAOK21.83108279
12PKN21.72343281
13BRD41.70879837
14MARK21.65467053
15SIK21.63486433
16MAP3K131.61281415
17MTOR1.53881617
18ERN11.50498783
19TTN1.41054046
20RIPK41.32455677
21PDGFRA1.30582962
22IRAK31.29265325
23MAP2K31.28586559
24TYRO31.26790686
25MAP4K11.26068776
26MAP3K71.18901673
27CAMK1G1.18542872
28RPS6KA21.16971919
29CDC42BPA1.16435485
30CAMK1D1.11812692
31KSR21.11130842
32RPS6KL11.06516595
33RPS6KC11.06516595
34PRKD21.02910338
35PRKD31.02193327
36CDK40.96309748
37RET0.95617961
38FGFR30.94336843
39ZAP700.88760969
40SGK30.85201070
41HIPK20.85159333
42LATS20.84293198
43MAP3K140.83814792
44MAPK110.83467921
45RPS6KA60.83182448
46PDPK10.82066839
47MAP2K20.80222336
48STK380.79294668
49PTK60.76249751
50TYK20.72730133
51MAP3K10.71801456
52RPS6KB20.71661504
53WNK10.68803477
54EPHB10.67701141
55BTK0.66722171
56MAP3K80.66603379
57BMX0.66114858
58DDR20.65708821
59CDK60.64779938
60MELK0.64523880
61DYRK1B0.64015339
62SIK30.63644766
63CDK90.63550990
64TAOK10.63169676
65JAK30.62933285
66NME20.61434214
67RPS6KA10.60509939
68CAMKK10.59877253
69MAP3K60.58914191
70MAP3K90.57960853
71PDK10.56786988
72PDGFRB0.56083696
73MAP3K30.55214704
74MAPK120.53473176
75CHUK0.53471278
76TNK20.52477340
77MAPK150.52445794
78NTRK10.51925903
79CDK70.51621520
80SGK2230.51572296
81SGK4940.51572296
82TBK10.49725280
83PAK20.49292330
84SGK20.48972828
85MAPK70.48715337
86FES0.46495726
87EPHA20.44259362
88MAPK100.43770484
89IRAK20.42520273
90HCK0.42518979
91AKT30.41636873
92PNCK0.40190662
93PTK20.38571012
94MAPK80.38097615
95CHEK10.37508653
96PASK0.37313643
97MAP2K60.37043041
98CAMK40.36286116
99MAPK10.36055289
100NEK60.35376286

Predicted pathways (KEGG)

RankGene SetZ-score
1Acute myeloid leukemia_Homo sapiens_hsa052212.31137453
2Chronic myeloid leukemia_Homo sapiens_hsa052202.23154855
3Non-small cell lung cancer_Homo sapiens_hsa052232.02541746
4Notch signaling pathway_Homo sapiens_hsa043302.02153474
5Other glycan degradation_Homo sapiens_hsa005111.99753126
6B cell receptor signaling pathway_Homo sapiens_hsa046621.89602687
7VEGF signaling pathway_Homo sapiens_hsa043701.73785268
8Endometrial cancer_Homo sapiens_hsa052131.66921065
9Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.64113773
10Pancreatic cancer_Homo sapiens_hsa052121.59940058
11mTOR signaling pathway_Homo sapiens_hsa041501.58716102
12Thyroid hormone signaling pathway_Homo sapiens_hsa049191.56377601
13Neurotrophin signaling pathway_Homo sapiens_hsa047221.54108372
14Renal cell carcinoma_Homo sapiens_hsa052111.53634503
15AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.51041802
16Prostate cancer_Homo sapiens_hsa052151.43179777
17Glioma_Homo sapiens_hsa052141.42403617
18ErbB signaling pathway_Homo sapiens_hsa040121.40932457
19Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.37060536
20Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.36206629
21Longevity regulating pathway - mammal_Homo sapiens_hsa042111.35738412
22Choline metabolism in cancer_Homo sapiens_hsa052311.33924986
23Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.33462674
24Osteoclast differentiation_Homo sapiens_hsa043801.32687642
25Thyroid cancer_Homo sapiens_hsa052161.32246958
26Phosphatidylinositol signaling system_Homo sapiens_hsa040701.29859822
27Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.29748490
28MicroRNAs in cancer_Homo sapiens_hsa052061.26875449
29Hepatitis B_Homo sapiens_hsa051611.26862445
30Bladder cancer_Homo sapiens_hsa052191.26190802
31Phospholipase D signaling pathway_Homo sapiens_hsa040721.24549549
32T cell receptor signaling pathway_Homo sapiens_hsa046601.22812034
33Estrogen signaling pathway_Homo sapiens_hsa049151.22405925
34Prolactin signaling pathway_Homo sapiens_hsa049171.20951108
35Colorectal cancer_Homo sapiens_hsa052101.20294637
36GnRH signaling pathway_Homo sapiens_hsa049121.18451742
37Central carbon metabolism in cancer_Homo sapiens_hsa052301.18086784
38Inositol phosphate metabolism_Homo sapiens_hsa005621.17038374
39Lysine degradation_Homo sapiens_hsa003101.14183841
40Small cell lung cancer_Homo sapiens_hsa052221.08200793
41Insulin signaling pathway_Homo sapiens_hsa049101.07169187
42Dorso-ventral axis formation_Homo sapiens_hsa043201.06313916
43TNF signaling pathway_Homo sapiens_hsa046681.03333174
44Influenza A_Homo sapiens_hsa051641.01469885
45Long-term potentiation_Homo sapiens_hsa047201.01378015
46Focal adhesion_Homo sapiens_hsa045101.00614280
47Toll-like receptor signaling pathway_Homo sapiens_hsa046201.00142527
48Toxoplasmosis_Homo sapiens_hsa051450.99847995
49FoxO signaling pathway_Homo sapiens_hsa040680.98691223
50Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.96492129
51HTLV-I infection_Homo sapiens_hsa051660.94134273
52Adherens junction_Homo sapiens_hsa045200.93723350
53mRNA surveillance pathway_Homo sapiens_hsa030150.93086444
54Hepatitis C_Homo sapiens_hsa051600.92514716
55AMPK signaling pathway_Homo sapiens_hsa041520.92065483
56Proteoglycans in cancer_Homo sapiens_hsa052050.91555227
57Prion diseases_Homo sapiens_hsa050200.90494560
58MAPK signaling pathway_Homo sapiens_hsa040100.89698136
59Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.89410584
60Apoptosis_Homo sapiens_hsa042100.88208052
61Insulin resistance_Homo sapiens_hsa049310.85568675
62Adipocytokine signaling pathway_Homo sapiens_hsa049200.83258019
63Leishmaniasis_Homo sapiens_hsa051400.82234404
64Amoebiasis_Homo sapiens_hsa051460.81797923
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.81680878
66Viral carcinogenesis_Homo sapiens_hsa052030.81548679
67Type II diabetes mellitus_Homo sapiens_hsa049300.80664807
68Sphingolipid signaling pathway_Homo sapiens_hsa040710.78879983
69Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76955606
70HIF-1 signaling pathway_Homo sapiens_hsa040660.74849834
71Measles_Homo sapiens_hsa051620.74820399
72Herpes simplex infection_Homo sapiens_hsa051680.70319012
73Melanogenesis_Homo sapiens_hsa049160.69593787
74NF-kappa B signaling pathway_Homo sapiens_hsa040640.69535391
75Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.69494736
76Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.69098945
77Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.69004516
78Pathways in cancer_Homo sapiens_hsa052000.68941892
79Glycosaminoglycan degradation_Homo sapiens_hsa005310.68345610
80Rap1 signaling pathway_Homo sapiens_hsa040150.66985404
81Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.66308418
82Chemokine signaling pathway_Homo sapiens_hsa040620.66151647
83Jak-STAT signaling pathway_Homo sapiens_hsa046300.65641646
84Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.65008767
85Endocytosis_Homo sapiens_hsa041440.64671402
86Platelet activation_Homo sapiens_hsa046110.63668689
87RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.62666399
88Transcriptional misregulation in cancer_Homo sapiens_hsa052020.61238739
89Aldosterone synthesis and secretion_Homo sapiens_hsa049250.60984872
90Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.60551077
91Regulation of actin cytoskeleton_Homo sapiens_hsa048100.59491893
92Carbohydrate digestion and absorption_Homo sapiens_hsa049730.58583452
93Gap junction_Homo sapiens_hsa045400.56397497
94ECM-receptor interaction_Homo sapiens_hsa045120.54991868
95Tuberculosis_Homo sapiens_hsa051520.53822952
96Melanoma_Homo sapiens_hsa052180.53746677
97Epstein-Barr virus infection_Homo sapiens_hsa051690.53660990
98Wnt signaling pathway_Homo sapiens_hsa043100.52053905
99Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.49716782
100cGMP-PKG signaling pathway_Homo sapiens_hsa040220.49699645

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