CRAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes carnitine O-acetyltransferase, a member of the carnitine acyltransferase family and a key metabolic pathway enzyme which plays an important role in energy homeostasis and fat metabolism. This enzyme catalyzes the reversible transfer of acyl groups from an acyl-CoA thioester to carnitine and regulates the ratio of acyl-CoA/CoA. It is found in both the mitochondria and the peroxisome. Alternative splicing results in transcript variants encoding different isoforms that may localize to different subcellular compartments. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1carnitine shuttle (GO:0006853)6.54931838
2tricarboxylic acid cycle (GO:0006099)6.44246757
3carnitine transmembrane transport (GO:1902603)6.26222323
4carnitine transport (GO:0015879)6.08756374
5amino-acid betaine transport (GO:0015838)6.08756374
6fatty acid transmembrane transport (GO:1902001)6.05958003
7regulation of sequestering of triglyceride (GO:0010889)5.66612489
8sarcomere organization (GO:0045214)5.62206835
9negative regulation of potassium ion transmembrane transporter activity (GO:1901017)5.49610548
10regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.05347157
11muscle filament sliding (GO:0030049)5.05201630
12actin-myosin filament sliding (GO:0033275)5.05201630
13cardiac myofibril assembly (GO:0055003)5.03667469
14sperm motility (GO:0030317)5.03457617
15negative regulation of potassium ion transmembrane transport (GO:1901380)4.82847679
16myofibril assembly (GO:0030239)4.77513084
17fusion of sperm to egg plasma membrane (GO:0007342)4.77388854
18quaternary ammonium group transport (GO:0015697)4.63627171
19regulation of acyl-CoA biosynthetic process (GO:0050812)4.55003164
20regulation of skeletal muscle contraction (GO:0014819)4.51269716
21acrosome reaction (GO:0007340)4.51047708
22* fatty acid beta-oxidation (GO:0006635)4.41867899
23positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.39765975
24regulation of fatty acid oxidation (GO:0046320)4.38931030
25plasma membrane repair (GO:0001778)4.38058166
26cilium or flagellum-dependent cell motility (GO:0001539)4.32725176
27NADH metabolic process (GO:0006734)4.25088215
28lysine metabolic process (GO:0006553)4.21271369
29lysine catabolic process (GO:0006554)4.21271369
30aspartate family amino acid catabolic process (GO:0009068)4.17895662
312-oxoglutarate metabolic process (GO:0006103)4.17584085
32regulation of coenzyme metabolic process (GO:0051196)4.13118505
33regulation of cofactor metabolic process (GO:0051193)4.13118505
34regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.09759680
35actin-mediated cell contraction (GO:0070252)4.08222293
36cardiac muscle contraction (GO:0060048)4.05045843
37sperm-egg recognition (GO:0035036)3.99249715
38acrosome assembly (GO:0001675)3.90786376
39regulation of cholesterol esterification (GO:0010872)3.89892913
40regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.88367899
41fructose metabolic process (GO:0006000)3.85110646
42cell wall macromolecule metabolic process (GO:0044036)3.84377369
43cell wall macromolecule catabolic process (GO:0016998)3.84377369
44protein carboxylation (GO:0018214)3.84117313
45peptidyl-glutamic acid carboxylation (GO:0017187)3.84117313
46* fatty acid catabolic process (GO:0009062)3.82921509
47positive regulation of lipoprotein lipase activity (GO:0051006)3.78180568
48positive regulation of triglyceride lipase activity (GO:0061365)3.78180568
49plasma membrane fusion (GO:0045026)3.77743751
50cardiac muscle cell development (GO:0055013)3.74565007
51motile cilium assembly (GO:0044458)3.74106546
52* fatty acid oxidation (GO:0019395)3.73765719
53multicellular organism reproduction (GO:0032504)3.73539681
54skeletal muscle contraction (GO:0003009)3.72149070
55positive regulation of fatty acid oxidation (GO:0046321)3.70066431
56biotin metabolic process (GO:0006768)3.68745347
57* lipid oxidation (GO:0034440)3.66930661
58sarcoplasmic reticulum calcium ion transport (GO:0070296)3.63723575
59triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.63035190
60binding of sperm to zona pellucida (GO:0007339)3.62406652
61regulation of actin filament-based movement (GO:1903115)3.61086640
62organic cation transport (GO:0015695)3.60034251
63cell-cell recognition (GO:0009988)3.57755984
64regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)3.57407111
65valine metabolic process (GO:0006573)3.57260427
66axonemal dynein complex assembly (GO:0070286)3.56460384
67sperm capacitation (GO:0048240)3.54936881
68positive regulation of fatty acid beta-oxidation (GO:0032000)3.53828104
69tricarboxylic acid metabolic process (GO:0072350)3.53608689
70acetyl-CoA metabolic process (GO:0006084)3.53037308
71intracellular lipid transport (GO:0032365)3.53034295
72striated muscle contraction (GO:0006941)3.52677836
73cardiac cell development (GO:0055006)3.50783052
74actomyosin structure organization (GO:0031032)3.47725595
75low-density lipoprotein particle clearance (GO:0034383)3.45507438
76lipid particle organization (GO:0034389)3.45492692
77glyoxylate metabolic process (GO:0046487)3.45446241
78urea metabolic process (GO:0019627)3.45228897
79creatine metabolic process (GO:0006600)3.44639771
80succinate metabolic process (GO:0006105)3.43530553
81ventricular cardiac muscle cell action potential (GO:0086005)3.40319880
82spermatid development (GO:0007286)3.39524956
83negative regulation of fibrinolysis (GO:0051918)3.38218233
84regulation of sulfur metabolic process (GO:0042762)3.36535016
85branched-chain amino acid catabolic process (GO:0009083)3.36277615
86nitrogen cycle metabolic process (GO:0071941)3.34904544
87regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.32000824
88epoxygenase P450 pathway (GO:0019373)3.31687177
89urea cycle (GO:0000050)3.31270122
90heart trabecula formation (GO:0060347)3.30775123
91piRNA metabolic process (GO:0034587)3.30681468
92fibrinolysis (GO:0042730)3.30284216
93regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.27866342
94regulation of relaxation of muscle (GO:1901077)3.27529051
95bundle of His cell to Purkinje myocyte communication (GO:0086069)3.25350967
96blood coagulation, intrinsic pathway (GO:0007597)3.23805712
97epithelial cilium movement (GO:0003351)3.22862770
98regulation of fatty acid beta-oxidation (GO:0031998)3.22411121
99regulation of triglyceride catabolic process (GO:0010896)3.22108589
100phospholipid efflux (GO:0033700)3.20177751
101reproduction (GO:0000003)3.20004138
102branched-chain amino acid metabolic process (GO:0009081)3.19782311
103synaptonemal complex organization (GO:0070193)3.19248322
104* monocarboxylic acid catabolic process (GO:0072329)3.16039943
105short-chain fatty acid metabolic process (GO:0046459)3.15842438
106erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.15526656
107L-phenylalanine metabolic process (GO:0006558)3.15526656
108regulation of fibrinolysis (GO:0051917)3.14566918
109cardiac muscle tissue morphogenesis (GO:0055008)3.14068793
110oxaloacetate metabolic process (GO:0006107)3.13941937
111negative regulation of inclusion body assembly (GO:0090084)3.13363225
112erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.13327016
113L-phenylalanine catabolic process (GO:0006559)3.13327016
114cardiac muscle hypertrophy (GO:0003300)3.12689836
115ethanol oxidation (GO:0006069)3.12490402
116triglyceride catabolic process (GO:0019433)3.11879403
117regulation of protein activation cascade (GO:2000257)3.11691758
118alpha-linolenic acid metabolic process (GO:0036109)3.10544247
119* fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.09360462
120protein-lipid complex assembly (GO:0065005)3.09331164
121gluconeogenesis (GO:0006094)3.08117659
122heart contraction (GO:0060047)3.07568927
123heart process (GO:0003015)3.07568927
124actin filament-based movement (GO:0030048)3.06405421
125adult heart development (GO:0007512)3.06078373
126response to muscle activity (GO:0014850)3.04211928
127glycogen catabolic process (GO:0005980)3.02675287
128striated muscle hypertrophy (GO:0014897)3.01259443
129positive regulation of lipid storage (GO:0010884)2.99730070
130response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.99478461
131complement activation, alternative pathway (GO:0006957)2.98608969
132glucan catabolic process (GO:0009251)2.96857947
133response to mercury ion (GO:0046689)2.96040447
134high-density lipoprotein particle remodeling (GO:0034375)2.93540405
135regulation of complement activation (GO:0030449)2.90281266
136regulation of plasminogen activation (GO:0010755)2.88875704
137protein-lipid complex remodeling (GO:0034368)2.85341389
138macromolecular complex remodeling (GO:0034367)2.85341389
139plasma lipoprotein particle remodeling (GO:0034369)2.85341389
140hexose biosynthetic process (GO:0019319)2.84814177
141negative regulation of hemostasis (GO:1900047)2.84731522
142negative regulation of blood coagulation (GO:0030195)2.84731522
143very-low-density lipoprotein particle assembly (GO:0034379)2.81874835
1444-hydroxyproline metabolic process (GO:0019471)2.79501079
145negative regulation of sterol transport (GO:0032372)2.77795282
146negative regulation of cholesterol transport (GO:0032375)2.77795282
147cellular polysaccharide catabolic process (GO:0044247)2.77274548
148plasma lipoprotein particle assembly (GO:0034377)2.76709141
149negative regulation of lipase activity (GO:0060192)2.76319691
150skeletal muscle fiber development (GO:0048741)2.74810716
151ethanol metabolic process (GO:0006067)2.74762946
152positive regulation of lipid catabolic process (GO:0050996)2.73524328
153plasma lipoprotein particle clearance (GO:0034381)2.68843249
154reverse cholesterol transport (GO:0043691)2.63768745
155monosaccharide biosynthetic process (GO:0046364)2.63732370
156muscle contraction (GO:0006936)2.61789668
157proline metabolic process (GO:0006560)2.61043808
158regulation of systemic arterial blood pressure by renin-angiotensin (GO:0003081)2.59874477
159negative regulation of coagulation (GO:0050819)2.58529106
160protein-lipid complex subunit organization (GO:0071825)2.57592833
161diacylglycerol metabolic process (GO:0046339)2.55854268
162very long-chain fatty acid metabolic process (GO:0000038)2.54914040
163negative regulation of wound healing (GO:0061045)2.52074847
164regulation of lipoprotein metabolic process (GO:0050746)2.51255610
165regulation of cholesterol metabolic process (GO:0090181)2.50516047
166drug catabolic process (GO:0042737)2.49388039
167hormone catabolic process (GO:0042447)2.48801743
168regulation of cholesterol homeostasis (GO:2000188)2.48531192
169acylglycerol catabolic process (GO:0046464)2.48350838
170neutral lipid catabolic process (GO:0046461)2.48350838
171polysaccharide catabolic process (GO:0000272)2.47580719
172barbed-end actin filament capping (GO:0051016)2.46820689
173acylglycerol homeostasis (GO:0055090)2.46287946
174triglyceride homeostasis (GO:0070328)2.46287946
175cholesterol efflux (GO:0033344)2.45609597
176regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.44788056

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.50327751
2* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse4.12979920
3* ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.92820060
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.57826447
5* RXR_22158963_ChIP-Seq_LIVER_Mouse2.92125699
6* PPARA_22158963_ChIP-Seq_LIVER_Mouse2.88466236
7* LXR_22158963_ChIP-Seq_LIVER_Mouse2.80146394
8TBX20_22080862_ChIP-Seq_HEART_Mouse2.64912331
9TBX20_22328084_ChIP-Seq_HEART_Mouse2.64912331
10EZH2_22144423_ChIP-Seq_EOC_Human2.58193017
11EP300_21415370_ChIP-Seq_HL-1_Mouse2.56391692
12* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.55311389
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.44059526
14FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.34918874
15PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.32487002
16ZNF263_19887448_ChIP-Seq_K562_Human2.22163496
17BP1_19119308_ChIP-ChIP_Hs578T_Human2.15526492
18TRIM28_21343339_ChIP-Seq_HEK293_Human1.95524810
19NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.94216656
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94096439
21ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.89922295
22PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.87523275
23RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.81076152
24TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.75825606
25PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.72322770
26ELK3_25401928_ChIP-Seq_HUVEC_Human1.72245558
27RACK7_27058665_Chip-Seq_MCF-7_Human1.66941099
28TP63_17297297_ChIP-ChIP_HaCaT_Human1.64176379
29TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.55076576
30SRY_22984422_ChIP-ChIP_TESTIS_Rat1.48540583
31TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.44932109
32DNAJC2_21179169_ChIP-ChIP_NT2_Human1.44839940
33KDM2B_26808549_Chip-Seq_SUP-B15_Human1.44027002
34EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.43914323
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41385449
36CLOCK_20551151_ChIP-Seq_293T_Human1.41308194
37THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.41123729
38TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.40777554
39PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.40249632
40SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40173444
41* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.37072877
42ERG_21242973_ChIP-ChIP_JURKAT_Human1.36867652
43PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.35291919
44ZFP281_18757296_ChIP-ChIP_E14_Mouse1.31641469
45KDM2B_26808549_Chip-Seq_K562_Human1.31380954
46MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.31249726
47CDX2_19796622_ChIP-Seq_MESCs_Mouse1.29369318
48CTCF_27219007_Chip-Seq_ERYTHROID_Human1.25971288
49SA1_27219007_Chip-Seq_ERYTHROID_Human1.25377236
50ESR1_20079471_ChIP-ChIP_T-47D_Human1.23957822
51* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.23825576
52WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21323798
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.21032755
54ZNF274_21170338_ChIP-Seq_K562_Hela1.16118486
55P63_26484246_Chip-Seq_KERATINOCYTES_Human1.14823470
56BCOR_27268052_Chip-Seq_Bcells_Human1.14052154
57CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.13912064
58* TP63_22573176_ChIP-Seq_HFKS_Human1.13232991
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.12839290
60CTCF_27219007_Chip-Seq_Bcells_Human1.12311417
61KDM2B_26808549_Chip-Seq_DND41_Human1.11878053
62SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.10931179
63SA1_27219007_Chip-Seq_Bcells_Human1.10211209
64DROSHA_22980978_ChIP-Seq_HELA_Human1.09529183
65KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.08551610
66LXR_22292898_ChIP-Seq_THP-1_Human1.07421386
67RAD21_21589869_ChIP-Seq_MESCs_Mouse1.07311349
68FOXA2_19822575_ChIP-Seq_HepG2_Human1.07070546
69TCF7_22412390_ChIP-Seq_EML_Mouse1.06843701
70BCL6_27268052_Chip-Seq_Bcells_Human1.06636098
71SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.04728443
72SPI1_20517297_ChIP-Seq_HL60_Human1.03972107
73TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.03904869
74* TET1_21490601_ChIP-Seq_MESCs_Mouse1.03755649
75ELK4_26923725_Chip-Seq_MESODERM_Mouse1.03398608
76CREB1_26743006_Chip-Seq_LNCaP_Human1.03250937
77NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02704791
78P68_20966046_ChIP-Seq_HELA_Human1.01566848
79P300_27058665_Chip-Seq_ZR-75-30cells_Human1.01378305
80JARID1B-DAIN_22020125_ChIP-Seq_ESCs_Mouse1.01285192
81FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.00307321
82GATA1_19941827_ChIP-Seq_MEL86_Mouse1.00263755
83PPAR_26484153_Chip-Seq_NCI-H1993_Human0.99904609
84SMC1_22415368_ChIP-Seq_MEFs_Mouse0.99334597
85KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98570072
86SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98415707
87NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.97763381
88SOX2_27498859_Chip-Seq_STOMACH_Mouse0.97085321
89MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96368064
90CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.96243227
91KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.96212322
92MYC_27129775_Chip-Seq_CORNEA_Mouse0.94560694
93OCT4_20526341_ChIP-Seq_ESCs_Human0.94464803
94RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.93843633
95SMC4_20622854_ChIP-Seq_HELA_Human0.93042443
96SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.92810742
97NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92254475
98KLF4_19829295_ChIP-Seq_ESCs_Human0.91469642
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90842984
100GATA2_21666600_ChIP-Seq_HMVEC_Human0.90625596
101SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.90163373
102EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.89656879
103STAT3_19079543_ChIP-ChIP_MESCs_Mouse0.89495453
104EZH2_27294783_Chip-Seq_ESCs_Mouse0.89361910
105PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.88870286
106SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.88342263
107E2F1_20622854_ChIP-Seq_HELA_Human0.88109727
108TET1_21451524_ChIP-Seq_MESCs_Mouse0.88092858
109CSB_26484114_Chip-Seq_FIBROBLAST_Human0.87833512
110ESR2_21235772_ChIP-Seq_MCF-7_Human0.87594689
111GATA1_19941826_ChIP-Seq_K562_Human0.87482925
112RUNX1_27514584_Chip-Seq_MCF-7_Human0.87301141
113ESR1_21235772_ChIP-Seq_MCF-7_Human0.86956738
114MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human0.86708559
115MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.86578672
116CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.85796165
117P53_21459846_ChIP-Seq_SAOS-2_Human0.85045970
118SUZ12_27294783_Chip-Seq_ESCs_Mouse0.84291524
119IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.83869534
120CBP_20019798_ChIP-Seq_JUKART_Human0.83869534
121TP53_23651856_ChIP-Seq_MEFs_Mouse0.83652469
122EGR1_23403033_ChIP-Seq_LIVER_Mouse0.83217723
123WDR5_24793694_ChIP-Seq_LNCAP_Human0.83100611
124RAC3_21632823_ChIP-Seq_H3396_Human0.82754020
125ERG_20517297_ChIP-Seq_VCAP_Human0.82576803
126BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.82038338
127* ELF1_20517297_ChIP-Seq_JURKAT_Human0.81509372
128FOXH1_21741376_ChIP-Seq_ESCs_Human0.80755324
129* YY1_22570637_ChIP-Seq_MALME-3M_Human0.80578273
130GATA4_21415370_ChIP-Seq_HL-1_Mouse0.79939214
131NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.79877109
132PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.79692061
133GATA2_19941826_ChIP-Seq_K562_Human0.79395329
134CTCF_21964334_ChIP-Seq_BJAB-B_Human0.78744931
135AUTS2_25519132_ChIP-Seq_293T-REX_Human0.78507368
136NFIB_24661679_ChIP-Seq_LUNG_Mouse0.77820707
137SOX9_24532713_ChIP-Seq_HFSC_Mouse0.77041936
138LUZP1_20508642_ChIP-Seq_ESCs_Mouse0.76890726
139GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse0.76183817
140JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.76135883
141PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.75691083
142SOX2_21211035_ChIP-Seq_LN229_Human0.75560906
143SOX2_22085726_ChIP-Seq_NPCs_Mouse0.75532412
144NANOG_20526341_ChIP-Seq_ESCs_Human0.75160765
145STAT1_17558387_ChIP-Seq_HELA_Human0.74962367
146FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.74787306
147KLF1_20508144_ChIP-Seq_FETAL-LIVER-ERYTHROID_Mouse0.74769026
148OCT4_19829295_ChIP-Seq_ESCs_Human0.74334305
149P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.73913346
150ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.73628547

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.58902985
2MP0003646_muscle_fatigue5.43489584
3MP0005410_abnormal_fertilization4.34153745
4MP0000751_myopathy4.25351464
5MP0004084_abnormal_cardiac_muscle3.86753661
6MP0005670_abnormal_white_adipose3.78736061
7MP0004130_abnormal_muscle_cell3.57378707
8MP0000749_muscle_degeneration3.45575731
9MP0004036_abnormal_muscle_relaxation3.42841178
10MP0004215_abnormal_myocardial_fiber3.24228194
11MP0005330_cardiomyopathy2.95715418
12MP0005666_abnormal_adipose_tissue2.84712125
13MP0004087_abnormal_muscle_fiber2.71018314
14MP0005620_abnormal_muscle_contractility2.31139704
15MP0002972_abnormal_cardiac_muscle2.27270318
16MP0000750_abnormal_muscle_regeneration2.25260500
17MP0002106_abnormal_muscle_physiology2.21733808
18MP0002269_muscular_atrophy2.20004406
19MP0008775_abnormal_heart_ventricle2.15328595
20MP0004145_abnormal_muscle_electrophysio2.11835121
21MP0006036_abnormal_mitochondrial_physio2.06659994
22MP0004185_abnormal_adipocyte_glucose2.06298741
23MP0001544_abnormal_cardiovascular_syste2.03507067
24MP0005385_cardiovascular_system_phenoty2.03507067
25MP0010630_abnormal_cardiac_muscle2.02005694
26MP0006138_congestive_heart_failure1.92033358
27MP0000759_abnormal_skeletal_muscle1.89308953
28MP0005058_abnormal_lysosome_morphology1.88691718
29MP0005375_adipose_tissue_phenotype1.86918453
30MP0000747_muscle_weakness1.82725266
31MP0004233_abnormal_muscle_weight1.82081312
32MP0003137_abnormal_impulse_conducting1.78444707
33MP0005369_muscle_phenotype1.76571663
34MP0001666_abnormal_nutrient_absorption1.72945067
35MP0002139_abnormal_hepatobiliary_system1.72606941
36MP0002971_abnormal_brown_adipose1.69961601
37MP0004484_altered_response_of1.63283131
38MP0003879_abnormal_hair_cell1.61116062
39MP0003868_abnormal_feces_composition1.58679204
40MP0003221_abnormal_cardiomyocyte_apopto1.56939915
41MP0005360_urolithiasis1.55210739
42MP0003828_pulmonary_edema1.47511406
43MP0005409_darkened_coat_color1.46400809
44MP0010329_abnormal_lipoprotein_level1.35875782
45MP0005365_abnormal_bile_salt1.34727009
46MP0009780_abnormal_chondrocyte_physiolo1.32493262
47MP0004085_abnormal_heartbeat1.31182773
48MP0002332_abnormal_exercise_endurance1.30656294
49MP0003950_abnormal_plasma_membrane1.29838906
50MP0001958_emphysema1.28356716
51MP0004858_abnormal_nervous_system1.27046370
52MP0003329_amyloid_beta_deposits1.25880237
53MP0005085_abnormal_gallbladder_physiolo1.25600970
54MP0003705_abnormal_hypodermis_morpholog1.25412271
55MP0003698_abnormal_male_reproductive1.24894436
56MP0002118_abnormal_lipid_homeostasis1.22334788
57MP0005464_abnormal_platelet_physiology1.19737738
58MP0008438_abnormal_cutaneous_collagen1.18796003
59MP0005332_abnormal_amino_acid1.11798426
60MP0003806_abnormal_nucleotide_metabolis1.10608637
61MP0000343_altered_response_to1.09084645
62MP0003191_abnormal_cellular_cholesterol1.06949376
63MP0005319_abnormal_enzyme/_coenzyme1.04166931
64MP0006035_abnormal_mitochondrial_morpho1.04018438
65MP0009115_abnormal_fat_cell1.02891466
66MP0004270_analgesia1.02656905
67MP0004043_abnormal_pH_regulation1.01906274
68MP0005334_abnormal_fat_pad1.01690334
69MP0001929_abnormal_gametogenesis1.01337965
70MP0004510_myositis1.01240202
71MP0000013_abnormal_adipose_tissue1.01002729
72MP0000003_abnormal_adipose_tissue1.00959989
73MP0005535_abnormal_body_temperature0.98386158
74MP0009840_abnormal_foam_cell0.97455916
75MP0002822_catalepsy0.94893602
76MP0005584_abnormal_enzyme/coenzyme_acti0.93690418
77MP0000604_amyloidosis0.93664615
78MP0005275_abnormal_skin_tensile0.92274580
79MP0002108_abnormal_muscle_morphology0.90087564
80MP0003252_abnormal_bile_duct0.88767039
81MP0008961_abnormal_basal_metabolism0.86876208
82MP0002078_abnormal_glucose_homeostasis0.86867219
83MP0003279_aneurysm0.85958692
84MP0002876_abnormal_thyroid_physiology0.85385949
85MP0005623_abnormal_meninges_morphology0.85293427
86MP0002796_impaired_skin_barrier0.85032375
87MP0002127_abnormal_cardiovascular_syste0.84801068
88MP0002249_abnormal_larynx_morphology0.84385842
89MP0002138_abnormal_hepatobiliary_system0.82649069
90MP0008260_abnormal_autophagy0.82397261
91MP0000266_abnormal_heart_morphology0.81477629
92MP0005266_abnormal_metabolism0.81429653
93MP0000609_abnormal_liver_physiology0.81096699
94MP0001849_ear_inflammation0.80537405
95MP0000230_abnormal_systemic_arterial0.79265817
96MP0004147_increased_porphyrin_level0.78474147
97MP0002234_abnormal_pharynx_morphology0.77556798
98MP0002896_abnormal_bone_mineralization0.76706899
99MP0004019_abnormal_vitamin_homeostasis0.76679828
100MP0005451_abnormal_body_composition0.75578924
101MP0005023_abnormal_wound_healing0.75389230
102MP0008875_abnormal_xenobiotic_pharmacok0.75179912
103MP0002970_abnormal_white_adipose0.75149389
104MP0009384_cardiac_valve_regurgitation0.72088164
105MP0003011_delayed_dark_adaptation0.72042264
106MP0000249_abnormal_blood_vessel0.71984653
107MP0000678_abnormal_parathyroid_gland0.69482628
108MP0005083_abnormal_biliary_tract0.69201817
109MP0010368_abnormal_lymphatic_system0.68898884
110MP0005166_decreased_susceptibility_to0.68774082
111MP0010030_abnormal_orbit_morphology0.68639730
112MP0008004_abnormal_stomach_pH0.68412895
113MP0003195_calcinosis0.68392381
114MP0005165_increased_susceptibility_to0.68056930
115MP0003656_abnormal_erythrocyte_physiolo0.66994352
116MP0009643_abnormal_urine_homeostasis0.66251770
117MP0008874_decreased_physiological_sensi0.65980285
118MP0003091_abnormal_cell_migration0.65620457
119MP0000733_abnormal_muscle_development0.65263107
120MP0001765_abnormal_ion_homeostasis0.61589493
121MP0002128_abnormal_blood_circulation0.59815271
122MP0002161_abnormal_fertility/fecundity0.58591077
123MP0005448_abnormal_energy_balance0.57909992
124MP0002909_abnormal_adrenal_gland0.57238226
125MP0001661_extended_life_span0.54106270
126MP0003567_abnormal_fetal_cardiomyocyte0.54043561
127MP0004272_abnormal_basement_membrane0.53399086
128MP0003566_abnormal_cell_adhesion0.50980069
129MP0003959_abnormal_lean_body0.49932938
130MP0003045_fibrosis0.48487334
131MP0005452_abnormal_adipose_tissue0.47287432

Predicted human phenotypes

RankGene SetZ-score
1Exercise-induced myalgia (HP:0003738)6.23401620
2Myoglobinuria (HP:0002913)5.79139221
3Sudden death (HP:0001699)5.77286723
4Exercise-induced muscle cramps (HP:0003710)5.59517004
5Calf muscle hypertrophy (HP:0008981)5.03451069
6Muscle fiber splitting (HP:0003555)4.96394716
7Muscle hypertrophy of the lower extremities (HP:0008968)4.79921612
8Hyporeflexia of lower limbs (HP:0002600)4.79710345
9Ventricular tachycardia (HP:0004756)4.77366726
10Rhabdomyolysis (HP:0003201)4.61050641
11Difficulty running (HP:0009046)4.31094476
12Myopathic facies (HP:0002058)4.20114299
13Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.07602826
14Asymmetric septal hypertrophy (HP:0001670)4.01310249
15Increased connective tissue (HP:0009025)3.98152813
16Dynein arm defect of respiratory motile cilia (HP:0012255)3.94753101
17Absent/shortened dynein arms (HP:0200106)3.94753101
18Lipoatrophy (HP:0100578)3.94147765
19Abnormality of the calf musculature (HP:0001430)3.88353352
20Centrally nucleated skeletal muscle fibers (HP:0003687)3.84101931
21Atrial fibrillation (HP:0005110)3.77289326
22Bundle branch block (HP:0011710)3.75689667
23Abnormality of the left ventricular outflow tract (HP:0011103)3.65262970
24Subaortic stenosis (HP:0001682)3.65262970
25Deep venous thrombosis (HP:0002625)3.59752718
26Distal lower limb muscle weakness (HP:0009053)3.56021396
27Right ventricular cardiomyopathy (HP:0011663)3.50924344
28Primary atrial arrhythmia (HP:0001692)3.46921492
29Round ear (HP:0100830)3.46316944
30Abnormality of fatty-acid metabolism (HP:0004359)3.33592259
31EMG: myopathic abnormalities (HP:0003458)3.33518041
32Supraventricular tachycardia (HP:0004755)3.31291922
33Distal lower limb amyotrophy (HP:0008944)3.28998957
34Type 1 muscle fiber predominance (HP:0003803)3.28987338
35Dilated cardiomyopathy (HP:0001644)3.27905582
36Supraventricular arrhythmia (HP:0005115)3.26809106
37Palpitations (HP:0001962)3.25817990
38Ulnar deviation of the wrist (HP:0003049)3.24234913
39Ketoacidosis (HP:0001993)3.20905845
40Ketosis (HP:0001946)3.13863101
41Difficulty climbing stairs (HP:0003551)3.07791645
42Muscle stiffness (HP:0003552)3.07121860
43Hypoglycemic coma (HP:0001325)3.07117637
44Syncope (HP:0001279)3.05179477
45Abnormality of monocarboxylic acid metabolism (HP:0010996)3.03248650
46Muscle fiber inclusion bodies (HP:0100299)3.01930094
47Heart block (HP:0012722)2.98224330
48Spinal rigidity (HP:0003306)2.97474787
49Abnormality of dicarboxylic acid metabolism (HP:0010995)2.97283377
50Dicarboxylic aciduria (HP:0003215)2.97283377
51Hyperglycinuria (HP:0003108)2.95794928
52Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.90649476
53Protrusio acetabuli (HP:0003179)2.89122531
54Myotonia (HP:0002486)2.83718816
55Atrioventricular block (HP:0001678)2.81859075
56Abnormal atrioventricular conduction (HP:0005150)2.81068131
57Complement deficiency (HP:0004431)2.79570456
58Ventricular arrhythmia (HP:0004308)2.77645083
59Increased variability in muscle fiber diameter (HP:0003557)2.72578439
60Prolonged QT interval (HP:0001657)2.69387271
61Systemic lupus erythematosus (HP:0002725)2.69353559
62Increased muscle lipid content (HP:0009058)2.65745687
63Abnormality of the Achilles tendon (HP:0005109)2.62790914
64Hyperammonemia (HP:0001987)2.58295965
65Abnormality of complement system (HP:0005339)2.55798517
66Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.54455904
67Abnormal respiratory motile cilium physiology (HP:0012261)2.54386637
68Xanthomatosis (HP:0000991)2.53431862
69Abnormality of skeletal muscle fiber size (HP:0012084)2.50704953
70Abnormality of serine family amino acid metabolism (HP:0010894)2.49633935
71Abnormality of glycine metabolism (HP:0010895)2.49633935
72Nasal polyposis (HP:0100582)2.47288547
73Menorrhagia (HP:0000132)2.47151916
74Lower limb amyotrophy (HP:0007210)2.47096985
75Hepatic necrosis (HP:0002605)2.44094298
76Achilles tendon contracture (HP:0001771)2.40540189
77Abnormality of the nasal mucosa (HP:0000433)2.40141006
78Hypoalphalipoproteinemia (HP:0003233)2.39341934
79Joint hemorrhage (HP:0005261)2.38240640
80Bulbar palsy (HP:0001283)2.38197847
81Rimmed vacuoles (HP:0003805)2.37531207
82Hyperlipoproteinemia (HP:0010980)2.35767853
83Ventricular fibrillation (HP:0001663)2.35350327
84Slender build (HP:0001533)2.35280886
85Nemaline bodies (HP:0003798)2.33992388
86Generalized muscle weakness (HP:0003324)2.33206172
87Infertility (HP:0000789)2.32283464
88Abnormal respiratory motile cilium morphology (HP:0005938)2.28922546
89Abnormal respiratory epithelium morphology (HP:0012253)2.28922546
90Abnormality of glutamine family amino acid metabolism (HP:0010902)2.24881300
91Premature rupture of membranes (HP:0001788)2.22643323
92Calcaneovalgus deformity (HP:0001848)2.20027152
93EMG: neuropathic changes (HP:0003445)2.17557604
94Neck muscle weakness (HP:0000467)2.17513334
95Hypolipoproteinemia (HP:0010981)2.16678564
96Facial diplegia (HP:0001349)2.16412479
97Cerebral edema (HP:0002181)2.14698399
98Conjunctival hamartoma (HP:0100780)2.08005686
99Rhinitis (HP:0012384)2.07455976
100Generalized aminoaciduria (HP:0002909)2.06366006
101Scapular winging (HP:0003691)2.06113164
102Chronic bronchitis (HP:0004469)2.05639270
103Nausea (HP:0002018)2.05247472
104Cholelithiasis (HP:0001081)2.03726863
105Abnormal mitochondria in muscle tissue (HP:0008316)2.03444033
106Hypobetalipoproteinemia (HP:0003563)2.03319475
107Prolonged partial thromboplastin time (HP:0003645)2.02480405
108Left ventricular hypertrophy (HP:0001712)2.01446286
109Hemorrhage of the eye (HP:0011885)2.01401733
110Abnormal gallbladder physiology (HP:0012438)2.01201570
111Cholecystitis (HP:0001082)2.01201570
112Purpura (HP:0000979)2.01022822
113Acute encephalopathy (HP:0006846)2.00207259
114Abnormality of aromatic amino acid family metabolism (HP:0004338)1.98957017
115Gowers sign (HP:0003391)1.98115166
116Areflexia of lower limbs (HP:0002522)1.95744093
117Insulin-resistant diabetes mellitus (HP:0000831)1.95382474
118Frequent falls (HP:0002359)1.95323003
119Dysmetric saccades (HP:0000641)1.95197569
120Deformed tarsal bones (HP:0008119)1.92767264
121Back pain (HP:0003418)1.91941707
122Vertebral compression fractures (HP:0002953)1.91238730
123Abnormal EKG (HP:0003115)1.90449450
124Oligomenorrhea (HP:0000876)1.90014844
125Ragged-red muscle fibers (HP:0003200)1.89498490
126Abnormality of the level of lipoprotein cholesterol (HP:0010979)1.88308191
127Malignant hyperthermia (HP:0002047)1.88238322
128Muscular dystrophy (HP:0003560)1.87469617
129Metabolic acidosis (HP:0001942)1.87420831
130Distal arthrogryposis (HP:0005684)1.86348704
131Testicular atrophy (HP:0000029)1.86322545
132Acute necrotizing encephalopathy (HP:0006965)1.85627753
133Abnormality of proline metabolism (HP:0010907)1.85216138
134Hydroxyprolinuria (HP:0003080)1.85216138
135Upper limb amyotrophy (HP:0009129)1.85044570
136Distal upper limb amyotrophy (HP:0007149)1.85044570
137Abnormality of the common coagulation pathway (HP:0010990)1.83116104
138Mildly elevated creatine phosphokinase (HP:0008180)1.82195981
139Foot dorsiflexor weakness (HP:0009027)1.81314970
140Proximal tubulopathy (HP:0000114)1.80228474
141Hyperinsulinemic hypoglycemia (HP:0000825)1.80101832
142Hamartoma of the eye (HP:0010568)1.78423435
143Hypertriglyceridemia (HP:0002155)1.78300990
144Abnormal gallbladder morphology (HP:0012437)1.77796791
145Abnormality of the foot musculature (HP:0001436)1.76285892
146Limb-girdle muscle atrophy (HP:0003797)1.76220028
147Increased mean platelet volume (HP:0011877)1.76023021
148Increased purine levels (HP:0004368)1.75807494
149Stridor (HP:0010307)1.75193979
150Glomerulonephritis (HP:0000099)1.74035870
151Gingival bleeding (HP:0000225)1.73487357
152Mitral stenosis (HP:0001718)1.71883953
153Aortic aneurysm (HP:0004942)1.68993552
154Absent phalangeal crease (HP:0006109)1.68375729
155Generalized amyotrophy (HP:0003700)1.64440998
156Amyloidosis (HP:0011034)1.62367502
157Hypercholesterolemia (HP:0003124)1.61807472

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK46.43857628
2PDK36.43857628
3PDK24.12716578
4TTN3.96973708
5TRIB33.34549627
6OBSCN3.19609727
7BCKDK3.09651426
8PHKG22.84010544
9PHKG12.84010544
10PRKD32.66192679
11LMTK22.64788837
12ICK2.40690487
13TESK12.25681378
14PKN22.08581814
15WNK41.93105486
16MYLK1.85392536
17PINK11.80994586
18PRPF4B1.60926676
19DMPK1.60502115
20DDR21.56657054
21PTK2B1.48290893
22NEK11.36048290
23LIMK11.35684799
24TESK21.26951786
25CAMK1D1.26172942
26EPHB21.26057661
27STK381.23741569
28PIK3CA1.23680229
29TIE11.23648521
30CAMK1G1.23345962
31ARAF1.22049010
32TAOK21.18126363
33SIK11.17979887
34STK391.17105995
35EPHA21.16755557
36MUSK1.10660873
37RIPK11.06498974
38KSR21.06412358
39PTK21.05439719
40MAP2K31.05300731
41MAP3K61.03551436
42ERN10.97242029
43PRKAA10.97137066
44MARK10.96272457
45MET0.95906313
46PRKAA20.95515414
47EPHA30.92999801
48NTRK10.92577995
49PDK10.88220249
50PDPK10.83181783
51MARK20.82663988
52BMX0.81601524
53MOS0.79760673
54MAP3K70.78531518
55WNK10.77983080
56ABL20.77420914
57LATS20.76617701
58PRKD20.74383506
59PIM20.73666594
60PRKD10.73323474
61MAPK120.72019199
62TGFBR20.70563849
63EPHB10.68598394
64ZAP700.68548385
65DYRK1B0.68283870
66MAPK70.68021736
67STK240.67311283
68RPS6KA20.65680797
69INSRR0.64390985
70ILK0.63594045
71PAK30.60864516
72NEK90.56875711
73PIK3CG0.55881440
74GRK70.55500869
75MAPKAPK30.55199948
76PDGFRA0.52787558
77STK38L0.52184044
78BRAF0.52135503
79MAP3K30.52021191
80MAP3K50.50032227
81IRAK30.49780196
82PTK60.48487653
83ROCK10.47662297
84CAMK2D0.46262456
85MAPK40.45401573
86FLT30.44289080
87MTOR0.42446932
88PRKACG0.42093725
89MAP2K40.39677017
90TAOK10.39407805
91CAMK2B0.38324472
92PRKG10.37513039
93STK40.37452312
94MAP2K60.37182660
95GRK50.36243559
96DAPK30.35968321
97MST1R0.34642516
98PAK40.34512807
99PKN10.33749053
100CDC42BPA0.33739316
101FGFR40.33573785
102TNK20.32299105
103FER0.31449930
104KDR0.30375457
105STK30.29167861
106TRPM70.29023471
107MAPK110.28230989
108MAP3K100.27661683
109PRKACB0.26965486
110CAMK10.24633153
111CAMK40.23070067
112NME10.21524773
113RET0.21491692
114PRKACA0.21374881
115PRKCH0.19897546
116SGK30.18504828
117RPS6KA10.18021015
118PAK60.17920545
119JAK10.17642820
120JAK20.16876730
121EEF2K0.16820096
122MAP3K110.16287114
123MAP2K10.15261439
124PRKG20.15179262
125CAMK2G0.14781723
126PAK20.14481833
127CAMK2A0.13814970
128TBK10.13173279
129AKT20.13069825
130NEK20.12896008
131STK110.12587907
132RPS6KA30.12354138
133MAP3K10.12242655
134LATS10.12170517

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000204.95710746
2Propanoate metabolism_Homo sapiens_hsa006404.35668208
3Fatty acid degradation_Homo sapiens_hsa000713.67015871
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.60704424
5Fatty acid metabolism_Homo sapiens_hsa012123.16183549
6Pyruvate metabolism_Homo sapiens_hsa006202.88557944
7Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.87496965
8Carbon metabolism_Homo sapiens_hsa012002.62449459
9PPAR signaling pathway_Homo sapiens_hsa033202.62127071
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.53677237
11Fatty acid biosynthesis_Homo sapiens_hsa000612.43041990
12Cardiac muscle contraction_Homo sapiens_hsa042602.37587189
13Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.30168837
14Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.07546266
15Cyanoamino acid metabolism_Homo sapiens_hsa004601.82065703
16Butanoate metabolism_Homo sapiens_hsa006501.81432848
17Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.75116987
18Dilated cardiomyopathy_Homo sapiens_hsa054141.72963688
19Histidine metabolism_Homo sapiens_hsa003401.62519198
20Fatty acid elongation_Homo sapiens_hsa000621.49771100
21Parkinsons disease_Homo sapiens_hsa050121.45056624
22Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.44222141
23Glucagon signaling pathway_Homo sapiens_hsa049221.44218270
24Tryptophan metabolism_Homo sapiens_hsa003801.39499463
25Adipocytokine signaling pathway_Homo sapiens_hsa049201.38358706
26Oxidative phosphorylation_Homo sapiens_hsa001901.37311099
27beta-Alanine metabolism_Homo sapiens_hsa004101.35481567
28Glycerolipid metabolism_Homo sapiens_hsa005611.34990993
29Biosynthesis of amino acids_Homo sapiens_hsa012301.30837942
30Starch and sucrose metabolism_Homo sapiens_hsa005001.26859387
31Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.24976217
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23571292
33Fat digestion and absorption_Homo sapiens_hsa049751.20116898
34Arginine biosynthesis_Homo sapiens_hsa002201.17058418
35* Peroxisome_Homo sapiens_hsa041461.14482175
36Alzheimers disease_Homo sapiens_hsa050101.11229389
37Nitrogen metabolism_Homo sapiens_hsa009101.10309385
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.08953940
39Insulin resistance_Homo sapiens_hsa049311.08914149
40Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.07978201
41Steroid hormone biosynthesis_Homo sapiens_hsa001401.07143644
42Huntingtons disease_Homo sapiens_hsa050161.06581509
43Other glycan degradation_Homo sapiens_hsa005111.05436892
44AMPK signaling pathway_Homo sapiens_hsa041521.03609423
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.00380736
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.96853675
47Renin-angiotensin system_Homo sapiens_hsa046140.96008147
48Fructose and mannose metabolism_Homo sapiens_hsa000510.88664357
49Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.87831987
50Insulin signaling pathway_Homo sapiens_hsa049100.86683681
51Prion diseases_Homo sapiens_hsa050200.85360803
52Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.85261627
53Drug metabolism - other enzymes_Homo sapiens_hsa009830.84316534
54Pentose phosphate pathway_Homo sapiens_hsa000300.83774358
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.83305962
56Lysine degradation_Homo sapiens_hsa003100.82366384
57Vitamin digestion and absorption_Homo sapiens_hsa049770.82146806
58Primary bile acid biosynthesis_Homo sapiens_hsa001200.81149712
59Vitamin B6 metabolism_Homo sapiens_hsa007500.80286741
60Phenylalanine metabolism_Homo sapiens_hsa003600.73877148
61Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73498174
62Bile secretion_Homo sapiens_hsa049760.73115556
63Arachidonic acid metabolism_Homo sapiens_hsa005900.71997663
64Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71436526
65alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.68534697
66Pentose and glucuronate interconversions_Homo sapiens_hsa000400.68269870
67Viral myocarditis_Homo sapiens_hsa054160.63971110
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.62447298
69ABC transporters_Homo sapiens_hsa020100.60951796
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.58838181
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.57512153
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.56293697
73Galactose metabolism_Homo sapiens_hsa000520.55542507
74Glycerophospholipid metabolism_Homo sapiens_hsa005640.54508155
75Arginine and proline metabolism_Homo sapiens_hsa003300.53746180
76Central carbon metabolism in cancer_Homo sapiens_hsa052300.52895281
77Selenocompound metabolism_Homo sapiens_hsa004500.52507473
78Circadian rhythm_Homo sapiens_hsa047100.51043256
79Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.50726602
80Carbohydrate digestion and absorption_Homo sapiens_hsa049730.50127248
81Amoebiasis_Homo sapiens_hsa051460.49163634
82Renin secretion_Homo sapiens_hsa049240.47173614
83Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47143765
84Linoleic acid metabolism_Homo sapiens_hsa005910.45240697
85Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44478007
86Platelet activation_Homo sapiens_hsa046110.44348887
87GnRH signaling pathway_Homo sapiens_hsa049120.44035888
88Type II diabetes mellitus_Homo sapiens_hsa049300.42104477
89Caffeine metabolism_Homo sapiens_hsa002320.41982357
90Aldosterone synthesis and secretion_Homo sapiens_hsa049250.41616151
91Dorso-ventral axis formation_Homo sapiens_hsa043200.41614093
92Tyrosine metabolism_Homo sapiens_hsa003500.41475622
93Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.41338935
94Sulfur metabolism_Homo sapiens_hsa009200.39180928
95Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.37446008
96HIF-1 signaling pathway_Homo sapiens_hsa040660.37352214
97Metabolic pathways_Homo sapiens_hsa011000.37245673
98Chemical carcinogenesis_Homo sapiens_hsa052040.35913680
99Complement and coagulation cascades_Homo sapiens_hsa046100.34186382
100Calcium signaling pathway_Homo sapiens_hsa040200.32012287
101Mineral absorption_Homo sapiens_hsa049780.31986125
102Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.30798687
103Glutathione metabolism_Homo sapiens_hsa004800.29682431
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29070693
105Pancreatic secretion_Homo sapiens_hsa049720.28473577
106Gap junction_Homo sapiens_hsa045400.27899756
107Pertussis_Homo sapiens_hsa051330.26576806
108Long-term potentiation_Homo sapiens_hsa047200.26442165
109Vascular smooth muscle contraction_Homo sapiens_hsa042700.25844916
110Focal adhesion_Homo sapiens_hsa045100.24334892
111Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22285432
112Sulfur relay system_Homo sapiens_hsa041220.19414106
113Staphylococcus aureus infection_Homo sapiens_hsa051500.17649563
114Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.17632096
115Gastric acid secretion_Homo sapiens_hsa049710.17623953
116Oxytocin signaling pathway_Homo sapiens_hsa049210.16665097
117Protein digestion and absorption_Homo sapiens_hsa049740.15924094
118Thyroid hormone signaling pathway_Homo sapiens_hsa049190.15247420
119Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.13044691
120ECM-receptor interaction_Homo sapiens_hsa045120.12157442
121Tight junction_Homo sapiens_hsa045300.11909650
122Retinol metabolism_Homo sapiens_hsa008300.11461685

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »