CRB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila crumbs localizes to the stalk of the fly photoreceptor and may be a component of the molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with a severe form of retinitis pigmentosa, RP12, and with Leber congenital amaurosis. Alternate splicing results in multiple transcript variants, some protein coding and some non-protein coding. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* eye photoreceptor cell development (GO:0042462)9.94368572
2retinal rod cell development (GO:0046548)9.32653188
3detection of light stimulus involved in sensory perception (GO:0050962)9.29879407
4detection of light stimulus involved in visual perception (GO:0050908)9.29879407
5phototransduction (GO:0007602)9.00315389
6phototransduction, visible light (GO:0007603)8.91717352
7GMP metabolic process (GO:0046037)8.61811808
8detection of visible light (GO:0009584)8.59068800
9detection of light stimulus (GO:0009583)8.55992617
10protein-chromophore linkage (GO:0018298)8.12857154
11visual perception (GO:0007601)7.86122825
12sensory perception of light stimulus (GO:0050953)7.78620321
13positive regulation of guanylate cyclase activity (GO:0031284)7.70913824
14photoreceptor cell differentiation (GO:0046530)7.47091821
15eye photoreceptor cell differentiation (GO:0001754)7.47091821
16regulation of guanylate cyclase activity (GO:0031282)6.86910372
17cellular response to light stimulus (GO:0071482)6.34823524
18detection of external stimulus (GO:0009581)6.03309436
19detection of abiotic stimulus (GO:0009582)5.95465867
20retina development in camera-type eye (GO:0060041)5.93954832
21regulation of inhibitory postsynaptic membrane potential (GO:0060080)5.24293112
22nonmotile primary cilium assembly (GO:0035058)5.24004916
23regulation of cGMP metabolic process (GO:0030823)5.17521940
24presynaptic membrane assembly (GO:0097105)4.97429595
25positive regulation of cGMP biosynthetic process (GO:0030828)4.72315307
26pyrimidine nucleobase catabolic process (GO:0006208)4.67062082
27retina layer formation (GO:0010842)4.50770204
28behavioral response to nicotine (GO:0035095)4.41758626
29regulation of cGMP biosynthetic process (GO:0030826)4.37568670
30positive regulation of cGMP metabolic process (GO:0030825)4.18426777
31cellular response to radiation (GO:0071478)4.16934472
32regulation of G-protein coupled receptor protein signaling pathway (GO:0008277)4.12366101
33postsynaptic membrane organization (GO:0001941)4.12290878
34negative regulation of synaptic transmission, GABAergic (GO:0032229)4.04961578
35sensory perception (GO:0007600)3.97670405
36cell morphogenesis involved in neuron differentiation (GO:0048667)3.96190963
37gamma-aminobutyric acid transport (GO:0015812)3.92030332
38adaptation of signaling pathway (GO:0023058)3.88536893
39nucleobase catabolic process (GO:0046113)3.85720345
40protein localization to synapse (GO:0035418)3.80446953
41protein prenylation (GO:0018342)3.80123858
42prenylation (GO:0097354)3.80123858
43estrogen biosynthetic process (GO:0006703)3.78855895
44positive regulation of oligodendrocyte differentiation (GO:0048714)3.74933584
45cell proliferation in forebrain (GO:0021846)3.52907211
46somite development (GO:0061053)3.48883760
47axoneme assembly (GO:0035082)3.46635310
48detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.46379548
49* neuron development (GO:0048666)3.45956319
50response to pheromone (GO:0019236)3.44792764
51receptor guanylyl cyclase signaling pathway (GO:0007168)3.44358806
52protein polyglutamylation (GO:0018095)3.41521950
53negative regulation of cytosolic calcium ion concentration (GO:0051481)3.39707992
54positive regulation of mitochondrial fission (GO:0090141)3.36506526
55limb bud formation (GO:0060174)3.33079830
56response to light stimulus (GO:0009416)3.31398924
57regulation of short-term neuronal synaptic plasticity (GO:0048172)3.30737512
58sulfation (GO:0051923)3.29525428
59membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.27141991
60positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.18509378
61indole-containing compound catabolic process (GO:0042436)3.16391660
62indolalkylamine catabolic process (GO:0046218)3.16391660
63tryptophan catabolic process (GO:0006569)3.16391660
64behavioral response to ethanol (GO:0048149)3.15336327
65retinal ganglion cell axon guidance (GO:0031290)3.14160767
66regulation of voltage-gated calcium channel activity (GO:1901385)3.12960501
67transmission of nerve impulse (GO:0019226)3.07550908
68peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan (GO:0019800)3.02174071
69membrane hyperpolarization (GO:0060081)3.01665408
70righting reflex (GO:0060013)3.01450963
71positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.00544923
72kynurenine metabolic process (GO:0070189)2.99700842
73startle response (GO:0001964)2.98952911
74spinal cord development (GO:0021510)2.98198450
75water-soluble vitamin biosynthetic process (GO:0042364)2.96169140
76indolalkylamine metabolic process (GO:0006586)2.95673290
77regulation of action potential (GO:0098900)2.94665434
78negative regulation of mast cell activation (GO:0033004)2.94593398
79regulation of collateral sprouting (GO:0048670)2.94382296
80tryptophan metabolic process (GO:0006568)2.94340805
81positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.94007617
82positive regulation of G-protein coupled receptor protein signaling pathway (GO:0045745)2.92803752
83regulation of timing of cell differentiation (GO:0048505)2.91227375
84detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.89339482
85mitochondrial respiratory chain complex I assembly (GO:0032981)2.87059949
86NADH dehydrogenase complex assembly (GO:0010257)2.87059949
87mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.87059949
88regulation of penile erection (GO:0060405)2.86729687
89G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.85918958
90auditory behavior (GO:0031223)2.84251631
91negative regulation of transcription regulatory region DNA binding (GO:2000678)2.82930979
92regulation of clathrin-mediated endocytosis (GO:2000369)2.80789811
93positive regulation of neurotransmitter transport (GO:0051590)2.79592951
94reflex (GO:0060004)2.79455390
95neuronal action potential (GO:0019228)2.79266238
96short-term memory (GO:0007614)2.79074151
97glycosphingolipid biosynthetic process (GO:0006688)2.77029410
98neural tube formation (GO:0001841)2.76906263
99neuronal action potential propagation (GO:0019227)2.76886490
100DNA deamination (GO:0045006)2.75542646
101mechanosensory behavior (GO:0007638)2.75227178
102olfactory bulb development (GO:0021772)2.74819396
103hippocampus development (GO:0021766)2.73549932
104retina homeostasis (GO:0001895)2.73274234
105response to histamine (GO:0034776)2.72830254
106epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.72805169
107fucose catabolic process (GO:0019317)2.72166354
108L-fucose metabolic process (GO:0042354)2.72166354
109L-fucose catabolic process (GO:0042355)2.72166354
110C4-dicarboxylate transport (GO:0015740)2.69208376
111glutamate receptor signaling pathway (GO:0007215)2.68067181
112regulation of cilium movement (GO:0003352)2.67131644
113dendritic spine morphogenesis (GO:0060997)2.67130617
114sympathetic nervous system development (GO:0048485)2.66291309
115ionotropic glutamate receptor signaling pathway (GO:0035235)2.64662821
116forebrain neuron differentiation (GO:0021879)2.64007607
117regulation of oligodendrocyte differentiation (GO:0048713)2.63441066
118epithelial cilium movement (GO:0003351)2.61065169
119synaptic transmission, glutamatergic (GO:0035249)2.60161288
120serotonin metabolic process (GO:0042428)2.59821668
121synaptic transmission, cholinergic (GO:0007271)2.59797008
122prostate gland growth (GO:0060736)2.58951690
123indole-containing compound metabolic process (GO:0042430)2.58306340
124regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.56264425
125regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.56264425
126regulation of neurotransmitter uptake (GO:0051580)2.56172777
127synaptic vesicle docking involved in exocytosis (GO:0016081)2.55652088
128positive regulation of potassium ion transmembrane transport (GO:1901381)2.54232516
129cornea development in camera-type eye (GO:0061303)2.53906023
130primary amino compound metabolic process (GO:1901160)2.52179892
131synapse assembly (GO:0007416)2.50598167
132dentate gyrus development (GO:0021542)2.50204300
133neuronal stem cell maintenance (GO:0097150)2.49145460
134presynaptic membrane organization (GO:0097090)2.48957323
135central nervous system projection neuron axonogenesis (GO:0021952)2.48796667
136chemosensory behavior (GO:0007635)2.48501667
137appendage development (GO:0048736)2.47745510
138limb development (GO:0060173)2.47745510
139neuron cell-cell adhesion (GO:0007158)2.46476798
140negative regulation of receptor-mediated endocytosis (GO:0048261)2.46373439
141embryonic epithelial tube formation (GO:0001838)2.44786675
142negative regulation of systemic arterial blood pressure (GO:0003085)2.43713880
143protein complex biogenesis (GO:0070271)2.43665097
144negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.43425226
145negative regulation of astrocyte differentiation (GO:0048712)2.40004259
146cerebral cortex radially oriented cell migration (GO:0021799)2.38829118
147positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.38579182
148positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.38319570
149axon ensheathment in central nervous system (GO:0032291)2.37756624
150cilium organization (GO:0044782)2.37641454
151positive regulation of epidermal growth factor receptor signaling pathway (GO:0045742)2.32952001
152response to radiation (GO:0009314)2.31543773
153regulation of neurotransmitter secretion (GO:0046928)2.30975593
154lactate metabolic process (GO:0006089)2.29524018
155post-embryonic morphogenesis (GO:0009886)2.27014212
156retinoid metabolic process (GO:0001523)2.25796968
157positive regulation of sodium ion transmembrane transport (GO:1902307)2.22712172
158axonal fasciculation (GO:0007413)2.22288237
159cilium assembly (GO:0042384)2.22173920
160protein heterotetramerization (GO:0051290)2.21550176
161calcium ion import (GO:0070509)2.18665013
162synaptic vesicle maturation (GO:0016188)2.17555862
163neuron recognition (GO:0008038)2.16801739
164detection of chemical stimulus involved in sensory perception of taste (GO:0050912)2.16728073
165regulation of development, heterochronic (GO:0040034)2.14772095
166positive regulation of ERBB signaling pathway (GO:1901186)2.14441665
167regulation of dopamine metabolic process (GO:0042053)2.14332145
168regulation of catecholamine metabolic process (GO:0042069)2.14332145
169histone H3-K4 trimethylation (GO:0080182)2.13977465
170regulation of synaptic vesicle exocytosis (GO:2000300)2.13367088
171protein localization to cilium (GO:0061512)2.13107114
172cerebellar Purkinje cell differentiation (GO:0021702)2.12378447
173dopamine receptor signaling pathway (GO:0007212)2.12253581
174regulation of rhodopsin mediated signaling pathway (GO:0022400)15.6050932
175rhodopsin mediated signaling pathway (GO:0016056)15.2670207
176retinal cone cell development (GO:0046549)12.4625673
177photoreceptor cell maintenance (GO:0045494)11.1034368
178* photoreceptor cell development (GO:0042461)10.5195697

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human3.86492362
2GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.13808788
3ZNF274_21170338_ChIP-Seq_K562_Hela2.91003275
4HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.80868369
5EZH2_22144423_ChIP-Seq_EOC_Human2.73492640
6IGF1R_20145208_ChIP-Seq_DFB_Human2.41019228
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.23246591
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.22660310
9VDR_22108803_ChIP-Seq_LS180_Human2.21302776
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.12697316
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.11967230
12SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.07999352
13FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.05950476
14JARID2_20064375_ChIP-Seq_MESCs_Mouse2.03592227
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.02718872
16SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.01674405
17CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.00723322
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.99873338
19ZFP57_27257070_Chip-Seq_ESCs_Mouse1.99464849
20NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.92333092
21EZH2_27294783_Chip-Seq_ESCs_Mouse1.92004522
22CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.90409729
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.87979992
24EED_16625203_ChIP-ChIP_MESCs_Mouse1.86610198
25RNF2_18974828_ChIP-Seq_MESCs_Mouse1.86504699
26EZH2_18974828_ChIP-Seq_MESCs_Mouse1.86504699
27EWS_26573619_Chip-Seq_HEK293_Human1.86213739
28RNF2_27304074_Chip-Seq_ESCs_Mouse1.83423298
29PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83316302
30JARID2_20075857_ChIP-Seq_MESCs_Mouse1.80652457
31RNF2_27304074_Chip-Seq_NSC_Mouse1.79762171
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.79393480
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.77730735
34SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.75083129
35P300_19829295_ChIP-Seq_ESCs_Human1.73909055
36CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.73817433
37SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.73757259
38SALL1_21062744_ChIP-ChIP_HESCs_Human1.70938353
39AR_21572438_ChIP-Seq_LNCaP_Human1.68559323
40RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.67305891
41REST_21632747_ChIP-Seq_MESCs_Mouse1.64401145
42DROSHA_22980978_ChIP-Seq_HELA_Human1.63972430
43* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.63657936
44* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.63244986
45MTF2_20144788_ChIP-Seq_MESCs_Mouse1.60125574
46CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59948925
47* NANOG_18555785_Chip-Seq_ESCs_Mouse1.59351599
48* SMAD4_21799915_ChIP-Seq_A2780_Human1.56718001
49CTBP2_25329375_ChIP-Seq_LNCAP_Human1.55860713
50ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.52455804
51SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.51823994
52FLI1_27457419_Chip-Seq_LIVER_Mouse1.51281192
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49170143
54AR_25329375_ChIP-Seq_VCAP_Human1.49064114
55HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.48880229
56* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.48461128
57MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.46980971
58CTBP1_25329375_ChIP-Seq_LNCAP_Human1.46808800
59PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.44995786
60PCGF2_27294783_Chip-Seq_ESCs_Mouse1.44564559
61OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.44140098
62BCAT_22108803_ChIP-Seq_LS180_Human1.43476203
63IRF1_19129219_ChIP-ChIP_H3396_Human1.43221706
64POU5F1_16153702_ChIP-ChIP_HESCs_Human1.41840417
65* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.41588139
66NR3C1_21868756_ChIP-Seq_MCF10A_Human1.39069085
67P53_22127205_ChIP-Seq_FIBROBLAST_Human1.37880275
68TAF15_26573619_Chip-Seq_HEK293_Human1.36149224
69* E2F1_18555785_Chip-Seq_ESCs_Mouse1.35458100
70BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.35112472
71* NFE2_27457419_Chip-Seq_LIVER_Mouse1.34518459
72CBP_20019798_ChIP-Seq_JUKART_Human1.34271661
73IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.34271661
74STAT3_23295773_ChIP-Seq_U87_Human1.33813303
75* CMYC_18555785_Chip-Seq_ESCs_Mouse1.32743425
76AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.32478097
77REST_18959480_ChIP-ChIP_MESCs_Mouse1.32283134
78* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.31346374
79* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.29186658
80* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28755782
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.28594227
82ER_23166858_ChIP-Seq_MCF-7_Human1.25936508
83* P53_22387025_ChIP-Seq_ESCs_Mouse1.25918000
84SMAD3_21741376_ChIP-Seq_EPCs_Human1.24778371
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.24638888
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24638888
87CDX2_19796622_ChIP-Seq_MESCs_Mouse1.23877736
88KLF5_20875108_ChIP-Seq_MESCs_Mouse1.22089385
89FUS_26573619_Chip-Seq_HEK293_Human1.21842118
90* STAT3_18555785_Chip-Seq_ESCs_Mouse1.20112942
91TCF4_23295773_ChIP-Seq_U87_Human1.19726073
92* EZH2_27294783_Chip-Seq_NPCs_Mouse1.18686145
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18664652
94* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.18050318
95RING1B_27294783_Chip-Seq_NPCs_Mouse1.17576024
96E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.17458755
97* TAL1_26923725_Chip-Seq_HPCs_Mouse1.17170918
98MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.14809532
99TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.14720207
100MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.14618083
101LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14324610
102RUNX2_22187159_ChIP-Seq_PCA_Human1.14307821
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.13969957
104AR_19668381_ChIP-Seq_PC3_Human1.13922174
105* SOX2_18555785_Chip-Seq_ESCs_Mouse1.13687258
106TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13463824
107* P300_18555785_Chip-Seq_ESCs_Mouse1.12501220
108TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.12492654
109FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.11541159
110DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.10512744
111SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.10185219
112KDM2B_26808549_Chip-Seq_REH_Human1.10126766
113* NMYC_18555785_Chip-Seq_ESCs_Mouse1.09992090
114SOX2_21211035_ChIP-Seq_LN229_Gbm1.08059371
115* CTCF_18555785_Chip-Seq_ESCs_Mouse1.07289852
116* KLF4_18555785_Chip-Seq_ESCs_Mouse1.06730737
117SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06670970
118IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06560185
119* ZFX_18555785_Chip-Seq_ESCs_Mouse1.06483556
120* SMAD3_21741376_ChIP-Seq_HESCs_Human1.06244650
121KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.06195117
122NOTCH1_21737748_ChIP-Seq_TLL_Human1.06098245
123* TBL1_22424771_ChIP-Seq_293T_Human1.05707978
124TCF4_22108803_ChIP-Seq_LS180_Human1.05412630
125* ESRRB_18555785_Chip-Seq_ESCs_Mouse1.05057546
126TP53_22573176_ChIP-Seq_HFKS_Human1.04408250
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.04183785
128* PRDM14_20953172_ChIP-Seq_ESCs_Human1.04096403
129FLI1_21867929_ChIP-Seq_TH2_Mouse1.02720603
130GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.02343000

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003011_delayed_dark_adaptation9.12117815
2MP0005551_abnormal_eye_electrophysiolog8.75035551
3MP0006072_abnormal_retinal_apoptosis5.99098282
4* MP0005253_abnormal_eye_physiology5.96561915
5* MP0005195_abnormal_posterior_eye3.54808570
6MP0002638_abnormal_pupillary_reflex3.38894523
7MP0001324_abnormal_eye_pigmentation3.33123023
8MP0005423_abnormal_somatic_nervous3.32627231
9MP0003950_abnormal_plasma_membrane3.32243344
10* MP0005391_vision/eye_phenotype2.91474440
11MP0002229_neurodegeneration2.41977448
12MP0002090_abnormal_vision2.41792071
13MP0002653_abnormal_ependyma_morphology2.34082680
14MP0006292_abnormal_olfactory_placode2.18876807
15MP0000049_abnormal_middle_ear2.12324761
16* MP0002752_abnormal_somatic_nervous2.04408409
17MP0001986_abnormal_taste_sensitivity1.90191746
18MP0001485_abnormal_pinna_reflex1.86751703
19MP0002102_abnormal_ear_morphology1.74672321
20MP0002751_abnormal_autonomic_nervous1.68304698
21MP0001502_abnormal_circadian_rhythm1.66678728
22MP0003880_abnormal_central_pattern1.62283697
23* MP0002882_abnormal_neuron_morphology1.54747479
24MP0002837_dystrophic_cardiac_calcinosis1.53395484
25MP0005171_absent_coat_pigmentation1.52482718
26MP0004133_heterotaxia1.50786100
27MP0001486_abnormal_startle_reflex1.44413141
28MP0001984_abnormal_olfaction1.41730704
29MP0003119_abnormal_digestive_system1.41344555
30MP0008877_abnormal_DNA_methylation1.39756567
31MP0002160_abnormal_reproductive_system1.34608886
32MP0008872_abnormal_physiological_respon1.33009559
33MP0005367_renal/urinary_system_phenotyp1.27685770
34MP0000516_abnormal_urinary_system1.27685770
35MP0002822_catalepsy1.21811520
36MP0005646_abnormal_pituitary_gland1.20386957
37MP0003938_abnormal_ear_development1.16948303
38MP0005394_taste/olfaction_phenotype1.16515245
39MP0005499_abnormal_olfactory_system1.16515245
40MP0004885_abnormal_endolymph1.13016076
41MP0008789_abnormal_olfactory_epithelium1.12588732
42MP0004270_analgesia1.09412785
43MP0003937_abnormal_limbs/digits/tail_de1.09032668
44MP0005670_abnormal_white_adipose1.07732690
45MP0009046_muscle_twitch1.06569334
46MP0010386_abnormal_urinary_bladder1.06017343
47MP0002938_white_spotting1.04951027
48MP0000631_abnormal_neuroendocrine_gland1.02250728
49* MP0001764_abnormal_homeostasis1.00206333
50MP0000778_abnormal_nervous_system0.99958079
51MP0004019_abnormal_vitamin_homeostasis0.99195198
52MP0005389_reproductive_system_phenotype0.98753676
53MP0005645_abnormal_hypothalamus_physiol0.97648774
54MP0002095_abnormal_skin_pigmentation0.97372778
55MP0004859_abnormal_synaptic_plasticity0.95744728
56MP0005197_abnormal_uvea_morphology0.95461021
57MP0002282_abnormal_trachea_morphology0.93101924
58MP0003635_abnormal_synaptic_transmissio0.92897948
59MP0002272_abnormal_nervous_system0.90592394
60MP0002064_seizures0.90297844
61MP0002909_abnormal_adrenal_gland0.90140105
62MP0003646_muscle_fatigue0.89679921
63MP0002233_abnormal_nose_morphology0.89590211
64MP0003195_calcinosis0.88362431
65MP0001963_abnormal_hearing_physiology0.88295731
66MP0006276_abnormal_autonomic_nervous0.88203235
67MP0004742_abnormal_vestibular_system0.87740974
68MP0002734_abnormal_mechanical_nocicepti0.87295184
69MP0000026_abnormal_inner_ear0.87246033
70MP0001188_hyperpigmentation0.86688969
71MP0001968_abnormal_touch/_nociception0.86293375
72MP0003283_abnormal_digestive_organ0.86159615
73MP0009250_abnormal_appendicular_skeleto0.85775818
74MP0002063_abnormal_learning/memory/cond0.85139579
75MP0009053_abnormal_anal_canal0.84697973
76MP0001286_abnormal_eye_development0.84268239
77MP0005248_abnormal_Harderian_gland0.83557805
78MP0000566_synostosis0.82469080
79MP0002572_abnormal_emotion/affect_behav0.82122652
80MP0005084_abnormal_gallbladder_morpholo0.81192802
81MP0003121_genomic_imprinting0.80673706
82MP0009745_abnormal_behavioral_response0.80160911
83MP0002067_abnormal_sensory_capabilities0.79196069
84MP0000647_abnormal_sebaceous_gland0.78730146
85MP0000013_abnormal_adipose_tissue0.77842528
86MP0002184_abnormal_innervation0.74513242
87MP0001346_abnormal_lacrimal_gland0.71898229
88MP0003787_abnormal_imprinting0.69690915
89MP0004233_abnormal_muscle_weight0.68685697
90MP0003890_abnormal_embryonic-extraembry0.66647294
91MP0002557_abnormal_social/conspecific_i0.65505156
92* MP0003634_abnormal_glial_cell0.65298254
93MP0005187_abnormal_penis_morphology0.64120727
94MP0002127_abnormal_cardiovascular_syste0.64042084
95MP0005386_behavior/neurological_phenoty0.63327064
96MP0004924_abnormal_behavior0.63327064
97MP0002332_abnormal_exercise_endurance0.61416313
98MP0002277_abnormal_respiratory_mucosa0.58302470
99MP0004142_abnormal_muscle_tone0.57126633
100MP0010030_abnormal_orbit_morphology0.55856807
101MP0008995_early_reproductive_senescence0.55584764
102MP0004782_abnormal_surfactant_physiolog0.54085381
103MP0002152_abnormal_brain_morphology0.48609118
104MP0001905_abnormal_dopamine_level0.46436741
105MP0001970_abnormal_pain_threshold0.45206630
106MP0003136_yellow_coat_color0.44817120
107MP0002736_abnormal_nociception_after0.44417239
108MP0002066_abnormal_motor_capabilities/c0.43896042
109MP0000955_abnormal_spinal_cord0.42752322
110MP0005379_endocrine/exocrine_gland_phen0.42195908
111MP0001440_abnormal_grooming_behavior0.40839973
112MP0008004_abnormal_stomach_pH0.40376051
113MP0000569_abnormal_digit_pigmentation0.39024332
114MP0008569_lethality_at_weaning0.38920256
115MP0002735_abnormal_chemical_nociception0.38583035
116MP0000462_abnormal_digestive_system0.38571503
117MP0002234_abnormal_pharynx_morphology0.37844355
118MP0001501_abnormal_sleep_pattern0.37411770
119MP0003137_abnormal_impulse_conducting0.36437799
120MP0003698_abnormal_male_reproductive0.35340601
121MP0004085_abnormal_heartbeat0.35237050
122MP0002697_abnormal_eye_size0.34072837
123MP0002876_abnormal_thyroid_physiology0.33523872
124MP0004811_abnormal_neuron_physiology0.33285304
125MP0003861_abnormal_nervous_system0.32946111
126MP0005310_abnormal_salivary_gland0.32414223
127MP0001529_abnormal_vocalization0.32401183
128MP0003122_maternal_imprinting0.31710018
129MP0002733_abnormal_thermal_nociception0.31590827
130MP0008260_abnormal_autophagy0.31500710
131MP0004145_abnormal_muscle_electrophysio0.29034227

Predicted human phenotypes

RankGene SetZ-score
1Pigmentary retinal degeneration (HP:0001146)8.33855251
2Central scotoma (HP:0000603)7.87782879
3* Chorioretinal atrophy (HP:0000533)7.76707962
4Dyschromatopsia (HP:0007641)7.73036198
5Abnormality of macular pigmentation (HP:0008002)7.45714346
6Attenuation of retinal blood vessels (HP:0007843)7.27815272
7Scotoma (HP:0000575)7.10679966
8* Pendular nystagmus (HP:0012043)6.66768816
9Decreased central vision (HP:0007663)6.48997539
10* Abolished electroretinogram (ERG) (HP:0000550)6.16319150
11* Photophobia (HP:0000613)5.39970423
12* Type II diabetes mellitus (HP:0005978)5.30460597
13Cone-rod dystrophy (HP:0000548)4.97772110
14Severe visual impairment (HP:0001141)4.96272237
15Macular degeneration (HP:0000608)4.84632327
16Posterior subcapsular cataract (HP:0007787)4.46996961
17Constricted visual fields (HP:0001133)4.46651869
18Choroideremia (HP:0001139)4.28857709
19* Retinitis pigmentosa (HP:0000510)4.24996240
20* Keratoconus (HP:0000563)4.16623280
21* Increased corneal curvature (HP:0100692)4.16623280
22Decreased electroretinogram (ERG) amplitude (HP:0000654)3.49404870
23Short 1st metacarpal (HP:0010034)3.23731786
24Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)3.23731786
25Progressive visual loss (HP:0000529)3.07033464
26Gait imbalance (HP:0002141)2.97966792
27Congenital primary aphakia (HP:0007707)2.93653151
28Abnormality of the 1st metacarpal (HP:0010009)2.85067493
29Retinal atrophy (HP:0001105)2.83221645
30Congenital sensorineural hearing impairment (HP:0008527)2.80616381
31Subcapsular cataract (HP:0000523)2.80246064
32Nephrogenic diabetes insipidus (HP:0009806)2.73276006
33Medial flaring of the eyebrow (HP:0010747)2.73173970
34Optic disc pallor (HP:0000543)2.62519796
35Stenosis of the external auditory canal (HP:0000402)2.60345138
36Type II lissencephaly (HP:0007260)2.58805285
37Oligodactyly (hands) (HP:0001180)2.53935787
38Intestinal atresia (HP:0011100)2.52967475
39Abnormality of the renal cortex (HP:0011035)2.48502257
40Focal seizures (HP:0007359)2.46497692
41Hemiparesis (HP:0001269)2.45703475
42True hermaphroditism (HP:0010459)2.42126698
43Short phalanx of the thumb (HP:0009660)2.39019920
44Gaze-evoked nystagmus (HP:0000640)2.38284208
45* Wide nasal bridge (HP:0000431)2.34268965
46Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.32669773
47* Vitreoretinal degeneration (HP:0000655)2.29218780
48Poor coordination (HP:0002370)2.24225139
49Vaginal atresia (HP:0000148)2.21510773
50Pancreatic fibrosis (HP:0100732)2.20928423
51Ectopic kidney (HP:0000086)2.19212689
52Genital tract atresia (HP:0001827)2.17500657
53Thyroid-stimulating hormone excess (HP:0002925)2.16369941
54Acute necrotizing encephalopathy (HP:0006965)2.08113762
55Hyperglycinemia (HP:0002154)2.07771824
56Aplasia/Hypoplasia of the lens (HP:0008063)2.06161621
57Cerebellar dysplasia (HP:0007033)2.05054438
58Renal hypoplasia (HP:0000089)2.02957961
59Pachygyria (HP:0001302)2.01975990
60Lissencephaly (HP:0001339)2.00106383
613-Methylglutaconic aciduria (HP:0003535)2.00008626
62Congenital stationary night blindness (HP:0007642)13.2312685
63* Bony spicule pigmentary retinopathy (HP:0007737)10.5381895
64Absent rod-and cone-mediated responses on ERG (HP:0007688)10.3966986
65Abnormal rod and cone electroretinograms (HP:0008323)10.0820918
66Renal cortical cysts (HP:0000803)1.99907421
67Retinal dysplasia (HP:0007973)1.99592870
68Adactyly (HP:0009776)1.98083903
69Absent speech (HP:0001344)1.96982825
70Methylmalonic acidemia (HP:0002912)1.96386865
71Progressive macrocephaly (HP:0004481)1.94581831
72Tented upper lip vermilion (HP:0010804)1.93121711
73Action tremor (HP:0002345)1.90440933
74Thyroiditis (HP:0100646)1.90370796
75Drooling (HP:0002307)1.90070614
76Aplasia/Hypoplasia of the fovea (HP:0008060)1.87275324
77Hypoplasia of the fovea (HP:0007750)1.87275324
78Severe muscular hypotonia (HP:0006829)1.85899144
79Abnormality of alanine metabolism (HP:0010916)1.84868781
80Hyperalaninemia (HP:0003348)1.84868781
81Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.84868781
82Aplasia/Hypoplasia of the tibia (HP:0005772)1.84797514
83Abnormality of the labia minora (HP:0012880)1.83466674
84Abnormality of the fovea (HP:0000493)1.83001019
85Rib fusion (HP:0000902)1.82717898
86Abnormality of the renal collecting system (HP:0004742)1.81936433
87Aplasia/Hypoplasia of the hallux (HP:0008362)1.81915781
88Febrile seizures (HP:0002373)1.80997662
89Pancreatic cysts (HP:0001737)1.80564267
90Polydipsia (HP:0001959)1.79939285
91Abnormal drinking behavior (HP:0030082)1.79939285
92Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)1.78290851
93Morphological abnormality of the middle ear (HP:0008609)1.77951908
94Tachypnea (HP:0002789)1.77842592
95Oligodactyly (HP:0012165)1.75356874
96Synostosis of carpal bones (HP:0005048)1.75241942
97Short hallux (HP:0010109)1.74169531
98Disproportionate short-trunk short stature (HP:0003521)1.73971457
99Acute encephalopathy (HP:0006846)1.73094644
100Aplasia/Hypoplasia of the sternum (HP:0006714)1.72373638
101Colon cancer (HP:0003003)1.72209479
102Abnormal mitochondria in muscle tissue (HP:0008316)1.71336852
103Mitochondrial inheritance (HP:0001427)1.70345315
104Aganglionic megacolon (HP:0002251)1.69939165
105Dialeptic seizures (HP:0011146)1.69543973
106Epileptic encephalopathy (HP:0200134)1.61528922
107Astigmatism (HP:0000483)1.58797966
108* Optic atrophy (HP:0000648)1.54006637
109Cystic liver disease (HP:0006706)1.49578129
110Severe Myopia (HP:0011003)1.47736979
111Polar cataract (HP:0010696)1.46732608
112Aplasia/Hypoplasia of the tongue (HP:0010295)1.44442715
113Horizontal nystagmus (HP:0000666)1.38582776
114Chorioretinal coloboma (HP:0000567)1.38446229
115Sclerocornea (HP:0000647)1.37262276
116Abnormality of midbrain morphology (HP:0002418)1.35093686
117Molar tooth sign on MRI (HP:0002419)1.35093686
118Septo-optic dysplasia (HP:0100842)1.34293493
119Progressive cerebellar ataxia (HP:0002073)1.30722183
120Specific learning disability (HP:0001328)1.30350492
121Aplasia/Hypoplasia of the macula (HP:0008059)1.26519297
122Asthma (HP:0002099)1.24102702
123Broad foot (HP:0001769)1.22023945
124Nephronophthisis (HP:0000090)1.21120171
125Dysdiadochokinesis (HP:0002075)1.17377816
126Chronic hepatic failure (HP:0100626)1.17326906
127Preaxial hand polydactyly (HP:0001177)1.17065117
128Recurrent sinusitis (HP:0011108)1.14900383
129Anencephaly (HP:0002323)1.14661372
130Retinal detachment (HP:0000541)1.14390029
131Congenital hepatic fibrosis (HP:0002612)1.12656710
132Postaxial foot polydactyly (HP:0001830)1.12642472
133Abnormality of the renal medulla (HP:0100957)1.10749337
134Postaxial hand polydactyly (HP:0001162)1.10462978
135Broad-based gait (HP:0002136)1.09714918
136Aplasia/Hypoplasia affecting the retina (HP:0008061)1.09020353
137Left ventricular hypertrophy (HP:0001712)1.08817823
138Interstitial pulmonary disease (HP:0006530)1.08405061
139Hyperventilation (HP:0002883)1.05397941
140Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.05328773
141Absent/shortened dynein arms (HP:0200106)1.04180331
142Dynein arm defect of respiratory motile cilia (HP:0012255)1.04180331
143Male pseudohermaphroditism (HP:0000037)1.04056389
144Focal motor seizures (HP:0011153)1.02446932
145Short foot (HP:0001773)1.01371965
146Abnormality of the parathyroid morphology (HP:0011766)1.01036085
147Decreased testicular size (HP:0008734)1.00501036
148Osteomalacia (HP:0002749)0.99634049
149Chromosomal breakage induced by crosslinking agents (HP:0003221)0.99574331
150Optic nerve hypoplasia (HP:0000609)0.97657714
151Abnormal ciliary motility (HP:0012262)0.95799883
152Anophthalmia (HP:0000528)0.92676322
153Visual hallucinations (HP:0002367)0.91671642
154Midline defect of the nose (HP:0004122)0.90773895
155Dental crowding (HP:0000678)0.90110706
156Hypodontia (HP:0000668)0.89944589
157Genetic anticipation (HP:0003743)0.89303476

Predicted kinase interactions (KEA)

RankGene SetZ-score
1GRK18.38052431
2PBK5.14826227
3FRK4.17237821
4IRAK22.82625137
5MAP4K22.71983478
6CASK2.63962997
7BRD42.22478327
8SIK32.18972150
9SIK22.16262275
10PINK12.12331451
11EPHA32.09859336
12MARK11.94287205
13MAP2K71.78732135
14CSNK1G21.76601177
15CSNK1G31.60238369
16INSRR1.59323767
17CDK191.54867626
18PRPF4B1.47053374
19CSNK1G11.45578801
20OXSR11.45357069
21CSNK1A1L1.45233706
22MAP3K41.43302020
23SGK2231.42810122
24SGK4941.42810122
25ADRBK11.41630427
26NTRK21.39873015
27NEK61.32802047
28TRIM281.31548493
29SGK21.30642597
30TNIK1.30480852
31MAPK131.27735841
32BCKDK1.27104140
33NUAK11.26171029
34TLK11.23108693
35ERBB21.16542963
36AKT31.14930120
37DYRK1A1.12255372
38TAF11.11148499
39PAK61.10107353
40VRK11.09408225
41STK391.08636766
42WNK41.06717149
43HIPK21.03875738
44BMPR1B1.03469809
45CDK31.02818315
46ACVR1B1.01922179
47DAPK21.01038811
48CAMK1G0.95220476
49BCR0.93078691
50BMPR20.92711469
51TAOK30.92420868
52MUSK0.91971013
53NTRK30.89809206
54PHKG10.87580253
55PHKG20.87580253
56MAPK70.87497545
57PAK30.87289678
58PLK20.85804132
59IRAK10.85320817
60PKN10.84700883
61PRKCZ0.82341197
62DYRK30.81211389
63LATS10.80065151
64YES10.79664885
65MKNK20.79563775
66ADRBK20.79323209
67MAPK120.77815643
68UHMK10.77187586
69CSNK1D0.76288006
70CAMK2A0.69536171
71MAP3K60.69002475
72PNCK0.66806826
73STK160.64437359
74EPHB20.61933371
75PRKCE0.61647208
76SGK30.60793105
77SGK10.60519884
78KSR10.59233213
79MKNK10.58855008
80PRKCB0.58119078
81PLK40.57791779
82CAMK1D0.56729699
83CDC70.56719566
84CSNK1A10.56176905
85GRK50.55995651
86CAMK2D0.55623171
87TGFBR10.54896147
88SRPK10.54188683
89DYRK20.53324833
90ZAK0.53305284
91FGFR20.53088362
92RPS6KA50.51848133
93CDK50.51714153
94CAMK2B0.49582318
95STK110.49108238
96PRKAA20.48530562
97CDK90.48513938
98CCNB10.48455963
99PRKAA10.47562498
100VRK20.46906458
101PRKD30.45565372
102GSK3B0.45190162
103WNK10.44764564
104EIF2AK20.44125191
105ERBB30.42746458
106PRKACA0.42083552
107MINK10.41710085
108PRKCG0.41619662
109PRKACG0.41093257
110WNK30.40780749
111TIE10.40533670
112MAPK90.39526925
113MAPK140.39427826
114RPS6KA30.39294390
115ROCK10.38749726
116PRKCH0.38464604
117MAPK150.37486909
118TXK0.37298545
119PRKD20.37242596
120PRKG10.36924585
121EPHA40.36631947
122ATR0.36162489
123TTK0.36016850
124CDK10.35796402
125PLK30.35318572
126PLK10.35212905
127MAPK100.34750993
128PIK3CA0.34105054
129MAP3K140.33993344
130GRK70.33789326
131MAP2K10.33325169
132CAMK40.33316924
133MAP2K40.32770869
134CAMK10.32661247
135PRKDC0.32501364
136CHEK20.32009908
137BRSK20.31824540
138STK38L0.31805863
139PRKCA0.30496323

Predicted pathways (KEGG)

RankGene SetZ-score
1Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.69537183
2Butanoate metabolism_Homo sapiens_hsa006502.31942416
3Phototransduction_Homo sapiens_hsa0474415.0574342
4Synaptic vesicle cycle_Homo sapiens_hsa047211.83451140
5Nitrogen metabolism_Homo sapiens_hsa009101.77584163
6Oxidative phosphorylation_Homo sapiens_hsa001901.62936837
7Olfactory transduction_Homo sapiens_hsa047401.56604983
8GABAergic synapse_Homo sapiens_hsa047271.49758852
9Protein export_Homo sapiens_hsa030601.47550310
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45849675
11Primary bile acid biosynthesis_Homo sapiens_hsa001201.44884221
12Tryptophan metabolism_Homo sapiens_hsa003801.44346707
13Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.42105183
14Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.39602779
15Nicotine addiction_Homo sapiens_hsa050331.33701350
16Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.29475752
17Selenocompound metabolism_Homo sapiens_hsa004501.28315648
18Homologous recombination_Homo sapiens_hsa034401.26526697
19Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26477554
20Morphine addiction_Homo sapiens_hsa050321.25082999
21Parkinsons disease_Homo sapiens_hsa050121.23640131
22RNA polymerase_Homo sapiens_hsa030201.19125205
23Glutamatergic synapse_Homo sapiens_hsa047241.18172431
24Circadian rhythm_Homo sapiens_hsa047101.16816603
25Propanoate metabolism_Homo sapiens_hsa006401.16119004
26Serotonergic synapse_Homo sapiens_hsa047261.14183084
27Caffeine metabolism_Homo sapiens_hsa002321.12582156
28Cholinergic synapse_Homo sapiens_hsa047251.09885039
29Steroid hormone biosynthesis_Homo sapiens_hsa001401.09396386
30Circadian entrainment_Homo sapiens_hsa047131.06222211
31Peroxisome_Homo sapiens_hsa041461.05362586
32Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04275552
33Chemical carcinogenesis_Homo sapiens_hsa052041.02689808
34beta-Alanine metabolism_Homo sapiens_hsa004100.96412521
35Dopaminergic synapse_Homo sapiens_hsa047280.93783486
36Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93224936
37Alzheimers disease_Homo sapiens_hsa050100.91919326
38Retinol metabolism_Homo sapiens_hsa008300.82541463
39Huntingtons disease_Homo sapiens_hsa050160.80888087
40Steroid biosynthesis_Homo sapiens_hsa001000.80780531
41Sulfur metabolism_Homo sapiens_hsa009200.77443483
42Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.76288187
43Dorso-ventral axis formation_Homo sapiens_hsa043200.75283884
44Insulin secretion_Homo sapiens_hsa049110.74227440
45Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.73090669
46Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.68196875
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.66581992
48Taste transduction_Homo sapiens_hsa047420.64242859
49Pentose and glucuronate interconversions_Homo sapiens_hsa000400.63529590
50Systemic lupus erythematosus_Homo sapiens_hsa053220.61085051
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.59623907
52Collecting duct acid secretion_Homo sapiens_hsa049660.58317445
53Cocaine addiction_Homo sapiens_hsa050300.55943247
54Phosphatidylinositol signaling system_Homo sapiens_hsa040700.54234285
55Maturity onset diabetes of the young_Homo sapiens_hsa049500.53745567
56Oxytocin signaling pathway_Homo sapiens_hsa049210.52064411
57Axon guidance_Homo sapiens_hsa043600.51243275
58Fat digestion and absorption_Homo sapiens_hsa049750.50852948
59Purine metabolism_Homo sapiens_hsa002300.50822069
60cAMP signaling pathway_Homo sapiens_hsa040240.50410585
61Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.50200543
62ABC transporters_Homo sapiens_hsa020100.50114964
63cGMP-PKG signaling pathway_Homo sapiens_hsa040220.50064411
64Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.49751880
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47368703
66Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.45801098
67SNARE interactions in vesicular transport_Homo sapiens_hsa041300.45331695
68Inositol phosphate metabolism_Homo sapiens_hsa005620.44943130
69Metabolic pathways_Homo sapiens_hsa011000.44567744
70Histidine metabolism_Homo sapiens_hsa003400.44441913
71Salivary secretion_Homo sapiens_hsa049700.44429066
72Ether lipid metabolism_Homo sapiens_hsa005650.43929361
73Non-homologous end-joining_Homo sapiens_hsa034500.43578382
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.43508954
75Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.41695022
76Oocyte meiosis_Homo sapiens_hsa041140.41641919
77Fatty acid metabolism_Homo sapiens_hsa012120.40621263
78Rheumatoid arthritis_Homo sapiens_hsa053230.38738028
79Calcium signaling pathway_Homo sapiens_hsa040200.38512266
80Renin secretion_Homo sapiens_hsa049240.37733731
81Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37702432
82Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.37451219
83Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.37415304
84Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37165509
85Sulfur relay system_Homo sapiens_hsa041220.36959738
86Linoleic acid metabolism_Homo sapiens_hsa005910.36917567
87Cardiac muscle contraction_Homo sapiens_hsa042600.36198384
88Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36088480
89Fatty acid biosynthesis_Homo sapiens_hsa000610.36084168
90Amphetamine addiction_Homo sapiens_hsa050310.35693640
91Ovarian steroidogenesis_Homo sapiens_hsa049130.34319367
92Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.34290246
93Alcoholism_Homo sapiens_hsa050340.33642402
94Dilated cardiomyopathy_Homo sapiens_hsa054140.33621367
95Ras signaling pathway_Homo sapiens_hsa040140.33397944
96Aldosterone synthesis and secretion_Homo sapiens_hsa049250.33228667
97Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.32793648
98Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.32642560
99Chemokine signaling pathway_Homo sapiens_hsa040620.32263336
100alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.31969606
101Folate biosynthesis_Homo sapiens_hsa007900.30545113
102Vibrio cholerae infection_Homo sapiens_hsa051100.30541459
103Gap junction_Homo sapiens_hsa045400.30285688
104Type II diabetes mellitus_Homo sapiens_hsa049300.29520420
105mRNA surveillance pathway_Homo sapiens_hsa030150.27434534
106Glycerophospholipid metabolism_Homo sapiens_hsa005640.27376159
107Gastric acid secretion_Homo sapiens_hsa049710.27330340
108Hedgehog signaling pathway_Homo sapiens_hsa043400.27305158
109Fatty acid elongation_Homo sapiens_hsa000620.26992984
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.26466538
111Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.26301279
112Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.25577364
113Pancreatic secretion_Homo sapiens_hsa049720.25426862
114Wnt signaling pathway_Homo sapiens_hsa043100.25035374
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24807714
116Sphingolipid metabolism_Homo sapiens_hsa006000.23869890
117MAPK signaling pathway_Homo sapiens_hsa040100.23745248
118Lysine degradation_Homo sapiens_hsa003100.23709336
119Long-term potentiation_Homo sapiens_hsa047200.23574639
120Fanconi anemia pathway_Homo sapiens_hsa034600.23038475
121Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.22723744
122Vascular smooth muscle contraction_Homo sapiens_hsa042700.22586234
123Basal cell carcinoma_Homo sapiens_hsa052170.22392698
124Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.22306537
125Carbohydrate digestion and absorption_Homo sapiens_hsa049730.22156337
126Mineral absorption_Homo sapiens_hsa049780.22011284
127Choline metabolism in cancer_Homo sapiens_hsa052310.21730762
128Long-term depression_Homo sapiens_hsa047300.21143824
129Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.20895257
130Notch signaling pathway_Homo sapiens_hsa043300.19727071
131Graft-versus-host disease_Homo sapiens_hsa053320.18781560
132RNA degradation_Homo sapiens_hsa030180.18724131
133Type I diabetes mellitus_Homo sapiens_hsa049400.18687244
134ErbB signaling pathway_Homo sapiens_hsa040120.17895241
135Autoimmune thyroid disease_Homo sapiens_hsa053200.16907924
136Basal transcription factors_Homo sapiens_hsa030220.15773549
137Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.15455077
138Phagosome_Homo sapiens_hsa041450.15325715
139GnRH signaling pathway_Homo sapiens_hsa049120.14220553
140Melanogenesis_Homo sapiens_hsa049160.13774583
141Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.12544070
142Allograft rejection_Homo sapiens_hsa053300.12496700
143Regulation of autophagy_Homo sapiens_hsa041400.11974752
144Arachidonic acid metabolism_Homo sapiens_hsa005900.11524843
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.10961038
146Glycerolipid metabolism_Homo sapiens_hsa005610.10188195

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