CRB2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a family of proteins that are components of the Crumbs cell polarity complex. In mammals, members of this family are thought to play a role in many cellular processes in early embryonic development. A similar protein in Drosophila determines apicobasal polarity in embryonic epithelial cells. Mutations in this gene are associated with focal segmental glomerulosclerosis 9, and with ventriculomegaly with cystic kidney disease. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1glomerular epithelial cell development (GO:0072310)8.33325836
2glomerular basement membrane development (GO:0032836)7.74938763
3glomerular visceral epithelial cell development (GO:0072015)7.34502912
4lung epithelium development (GO:0060428)6.13079927
5paraxial mesoderm development (GO:0048339)5.22015958
6negative regulation of axon guidance (GO:1902668)4.91846639
7pyrimidine nucleobase catabolic process (GO:0006208)4.75877970
8glomerulus development (GO:0032835)4.67121594
9postsynaptic membrane organization (GO:0001941)4.62221964
10lateral sprouting from an epithelium (GO:0060601)4.61631247
11presynaptic membrane organization (GO:0097090)4.52144752
12neuron projection extension involved in neuron projection guidance (GO:1902284)4.46436716
13axon extension involved in axon guidance (GO:0048846)4.46436716
14establishment of planar polarity (GO:0001736)4.44988885
15establishment of tissue polarity (GO:0007164)4.44988885
16cell proliferation involved in metanephros development (GO:0072203)4.36062066
17lung-associated mesenchyme development (GO:0060484)4.34579092
18presynaptic membrane assembly (GO:0097105)4.27035895
19astrocyte differentiation (GO:0048708)4.20399687
20embryonic foregut morphogenesis (GO:0048617)4.12404849
21neuron recognition (GO:0008038)4.10286896
22cell migration in hindbrain (GO:0021535)4.02025995
23neuronal stem cell maintenance (GO:0097150)4.01860761
24negative regulation of mesenchymal cell apoptotic process (GO:2001054)3.94602373
25left/right axis specification (GO:0070986)3.93540976
26lens fiber cell development (GO:0070307)3.93524706
27dopaminergic neuron differentiation (GO:0071542)3.92015887
28regulation of axon guidance (GO:1902667)3.90457296
29regulation of mesenchymal cell apoptotic process (GO:2001053)3.84934081
30establishment of apical/basal cell polarity (GO:0035089)3.81598799
31locomotory exploration behavior (GO:0035641)3.81477089
32planar cell polarity pathway involved in neural tube closure (GO:0090179)3.81057145
33establishment of nucleus localization (GO:0040023)3.77805544
34cell proliferation in forebrain (GO:0021846)3.71264011
35spinal cord development (GO:0021510)3.69005570
36regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.68810196
37negative regulation of axon extension involved in axon guidance (GO:0048843)3.68714240
38cilium movement (GO:0003341)3.66948327
39cerebral cortex radially oriented cell migration (GO:0021799)3.66189973
40negative regulation of oligodendrocyte differentiation (GO:0048715)3.65752197
41limb bud formation (GO:0060174)3.64651569
42regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.64119359
43tongue development (GO:0043586)3.62052058
44neuronal ion channel clustering (GO:0045161)3.57551499
45pre-miRNA processing (GO:0031054)3.56334339
46nucleobase catabolic process (GO:0046113)3.53943980
47midbrain development (GO:0030901)3.53903423
48establishment or maintenance of monopolar cell polarity (GO:0061339)3.53629880
49establishment of monopolar cell polarity (GO:0061162)3.53629880
50regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.52784787
51spinal cord association neuron differentiation (GO:0021527)3.51693926
52coronary vasculature morphogenesis (GO:0060977)3.50312870
53branching involved in salivary gland morphogenesis (GO:0060445)3.44336278
54mesenchymal cell proliferation (GO:0010463)3.40699528
55epithelial cell differentiation involved in kidney development (GO:0035850)3.40456291
56dendritic spine morphogenesis (GO:0060997)3.38185095
57ventricular system development (GO:0021591)3.34147218
58regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.33793855
59artery development (GO:0060840)3.33758552
60positive regulation of neuroblast proliferation (GO:0002052)3.31116011
61substrate-independent telencephalic tangential migration (GO:0021826)3.29422982
62substrate-independent telencephalic tangential interneuron migration (GO:0021843)3.29422982
63epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.28757355
64neuron fate determination (GO:0048664)3.28274334
65axonemal dynein complex assembly (GO:0070286)3.26291210
66somite development (GO:0061053)3.25971774
67thalamus development (GO:0021794)3.20683219
68renal filtration (GO:0097205)3.19845096
69hippo signaling (GO:0035329)3.19190575
70axonal fasciculation (GO:0007413)3.10332656
71central nervous system myelination (GO:0022010)3.08355816
72axon ensheathment in central nervous system (GO:0032291)3.08355816
73radial glial cell differentiation (GO:0060019)3.06207267
74heart valve formation (GO:0003188)3.06161723
75notochord development (GO:0030903)3.05855466
76exploration behavior (GO:0035640)3.03910717
77regulation of axon extension involved in axon guidance (GO:0048841)3.03059278
78nonmotile primary cilium assembly (GO:0035058)3.01825459
79cell proliferation involved in kidney development (GO:0072111)3.01422481
80establishment of mitochondrion localization (GO:0051654)3.00174954
81endocardial cushion morphogenesis (GO:0003203)3.00148663
82Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.99738817
83positive regulation of synapse assembly (GO:0051965)2.99543804
84axon extension (GO:0048675)2.98954757
85body morphogenesis (GO:0010171)2.97778487
86venous blood vessel morphogenesis (GO:0048845)2.97429087
87regulation of oligodendrocyte differentiation (GO:0048713)2.97370067
88short-term memory (GO:0007614)2.97288255
89retinal rod cell development (GO:0046548)2.97246172
90G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.97101762
91glomerular filtration (GO:0003094)2.96494215
92forebrain neuron differentiation (GO:0021879)2.95418596
93negative regulation of smooth muscle cell differentiation (GO:0051151)2.95281280
94limb development (GO:0060173)2.94896630
95appendage development (GO:0048736)2.94896630
96regulation of non-canonical Wnt signaling pathway (GO:2000050)2.94324596
97apical protein localization (GO:0045176)2.91710194
98retinal ganglion cell axon guidance (GO:0031290)2.91572751
99negative regulation of catenin import into nucleus (GO:0035414)2.91489133
100central nervous system projection neuron axonogenesis (GO:0021952)2.90143467
101regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90113851
102positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.88617392
103asymmetric protein localization (GO:0008105)2.88265125
104camera-type eye morphogenesis (GO:0048593)2.87329399
105neuroblast proliferation (GO:0007405)2.86243035
106regulation of establishment of planar polarity (GO:0090175)2.86065135
107epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.84839015
108positive regulation of oligodendrocyte differentiation (GO:0048714)2.84023094
109embryonic body morphogenesis (GO:0010172)2.82892319
110negative regulation of astrocyte differentiation (GO:0048712)2.82747307
111non-canonical Wnt signaling pathway (GO:0035567)2.81761327
112transmission of nerve impulse (GO:0019226)2.81390011
113regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.81169757
114myelination in peripheral nervous system (GO:0022011)2.80396315
115peripheral nervous system axon ensheathment (GO:0032292)2.80396315
116positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.80028203
117synaptic vesicle endocytosis (GO:0048488)2.78717328
118cellular response to cholesterol (GO:0071397)2.77926638
119cilium or flagellum-dependent cell motility (GO:0001539)2.76896361
120neuron cell-cell adhesion (GO:0007158)2.76653087
121mesenchyme morphogenesis (GO:0072132)2.75342281
122regulation of mesoderm development (GO:2000380)2.74978781
123outer ear morphogenesis (GO:0042473)2.74960137
124negative regulation of glial cell differentiation (GO:0045686)2.73590768
125skeletal muscle organ development (GO:0060538)2.73199773
126photoreceptor cell development (GO:0042461)2.73040325
127mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.72902205
128lens morphogenesis in camera-type eye (GO:0002089)2.71242660
129olfactory bulb development (GO:0021772)2.70398163
130negative regulation of smoothened signaling pathway (GO:0045879)2.70038914
131post-anal tail morphogenesis (GO:0036342)2.68514784
132hindlimb morphogenesis (GO:0035137)2.67161257
133dorsal/ventral neural tube patterning (GO:0021904)2.67004395
134protein localization to synapse (GO:0035418)2.66738945
135photoreceptor cell differentiation (GO:0046530)2.66259049
136eye photoreceptor cell differentiation (GO:0001754)2.66259049
137positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.64107860
138cell surface receptor signaling pathway involved in heart development (GO:0061311)2.63827104
139renal system development (GO:0072001)2.63166553
140axoneme assembly (GO:0035082)2.62676159
141embryonic hindlimb morphogenesis (GO:0035116)2.62517106
142forebrain development (GO:0030900)2.61765789
143somatic stem cell division (GO:0048103)2.61057596
144Notch signaling involved in heart development (GO:0061314)2.60698638
145eye photoreceptor cell development (GO:0042462)2.60611508
146pattern specification involved in kidney development (GO:0061004)2.60153743
147dendrite morphogenesis (GO:0048813)2.60049485
148neuron migration (GO:0001764)2.57725468
149convergent extension (GO:0060026)2.57651493
150layer formation in cerebral cortex (GO:0021819)2.56926585
151embryonic retina morphogenesis in camera-type eye (GO:0060059)2.56610769
152negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.56400068
153positive regulation of smoothened signaling pathway (GO:0045880)2.56366685
154positive regulation of neural precursor cell proliferation (GO:2000179)2.55973136
155cochlea morphogenesis (GO:0090103)2.54891759
156regulation of somitogenesis (GO:0014807)2.53445298
157nucleus localization (GO:0051647)2.52827966
158positive regulation of gastrulation (GO:2000543)2.52769825
159regulation of organ formation (GO:0003156)2.52139070

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.30967744
2EED_16625203_ChIP-ChIP_MESCs_Mouse2.91514813
3PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.90684797
4EZH2_18974828_ChIP-Seq_MESCs_Mouse2.70833367
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.70833367
6EZH2_27304074_Chip-Seq_ESCs_Mouse2.67770459
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.62674566
8EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse2.62230618
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.55517530
10RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.51340398
11CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.51162459
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.47382420
13CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.45790642
14JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44856819
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.43880603
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.43029070
17ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.36790696
18* RNF2_27304074_Chip-Seq_ESCs_Mouse2.34600305
19CBX2_27304074_Chip-Seq_ESCs_Mouse2.25113608
20* EZH2_27294783_Chip-Seq_ESCs_Mouse2.20367019
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.18918765
22WT1_19549856_ChIP-ChIP_CCG9911_Human2.13092657
23SMAD3_22036565_ChIP-Seq_ESCs_Mouse2.10511440
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.09862450
25TP53_20018659_ChIP-ChIP_R1E_Mouse2.08954245
26RING1B_27294783_Chip-Seq_NPCs_Mouse2.07517834
27FOXM1_23109430_ChIP-Seq_U2OS_Human2.03519921
28ERG_21242973_ChIP-ChIP_JURKAT_Human2.03429918
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01937946
30TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.00042619
31RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.97157731
32SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95843244
33WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.93577654
34ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.92164235
35REST_21632747_ChIP-Seq_MESCs_Mouse1.83892312
36ZFP281_18757296_ChIP-ChIP_E14_Mouse1.81458305
37GATA1_26923725_Chip-Seq_HPCs_Mouse1.80771278
38GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.74081165
39MTF2_20144788_ChIP-Seq_MESCs_Mouse1.73958207
40RING1B_27294783_Chip-Seq_ESCs_Mouse1.73669283
41* ISL1_27105846_Chip-Seq_CPCs_Mouse1.69678587
42* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.69369915
43EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62307221
44IGF1R_20145208_ChIP-Seq_DFB_Human1.62054827
45* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.62037415
46ZFP281_27345836_Chip-Seq_ESCs_Mouse1.60318878
47POU5F1_16153702_ChIP-ChIP_HESCs_Human1.58514946
48REST_18959480_ChIP-ChIP_MESCs_Mouse1.53428770
49RBPJ_22232070_ChIP-Seq_NCS_Mouse1.52502679
50SOX2_16153702_ChIP-ChIP_HESCs_Human1.52443322
51TRIM28_21343339_ChIP-Seq_HEK293_Human1.49445936
52RNF2_27304074_Chip-Seq_NSC_Mouse1.46437472
53BMI1_23680149_ChIP-Seq_NPCS_Mouse1.43443779
54SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.42716324
55SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.41715375
56DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.41094703
57CTCF_27219007_Chip-Seq_Bcells_Human1.40408464
58E2F7_22180533_ChIP-Seq_HELA_Human1.39831034
59DROSHA_22980978_ChIP-Seq_HELA_Human1.37531527
60SOX2_18555785_ChIP-Seq_MESCs_Mouse1.36406049
61MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.30995642
62TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.29040181
63ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.27980054
64TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.27507550
65YAP1_20516196_ChIP-Seq_MESCs_Mouse1.26074867
66EP300_21415370_ChIP-Seq_HL-1_Mouse1.25869013
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.24461564
68KDM2B_26808549_Chip-Seq_K562_Human1.23934078
69KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.21373582
70NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.20498843
71SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.17771130
72WDR5_24793694_ChIP-Seq_LNCAP_Human1.15714315
73RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.15681767
74* RARB_27405468_Chip-Seq_BRAIN_Mouse1.15642163
75* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13656435
76* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.13656435
77FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.13355753
78TCF3_18692474_ChIP-Seq_MESCs_Mouse1.13334568
79CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12463168
80* SOX3_22085726_ChIP-Seq_NPCs_Mouse1.11719134
81PIAS1_25552417_ChIP-Seq_VCAP_Human1.10654667
82CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.09601680
83* AR_19668381_ChIP-Seq_PC3_Human1.07189597
84TBX3_20139965_ChIP-Seq_ESCs_Mouse1.04774389
85GBX2_23144817_ChIP-Seq_PC3_Human1.04773014
86TBX3_20139965_ChIP-Seq_MESCs_Mouse1.04028631
87NANOG_21062744_ChIP-ChIP_HESCs_Human1.03612075
88NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03553753
89TCF3_18347094_ChIP-ChIP_MESCs_Mouse1.03315669
90PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.03314357
91STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.02951563
92SOX9_26525672_Chip-Seq_HEART_Mouse1.02584569
93* TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02056926
94POU5F1_16518401_ChIP-PET_MESCs_Mouse1.02027768
95IKZF1_21737484_ChIP-ChIP_HCT116_Human1.01944233
96TCF3_18692474_ChIP-Seq_MEFs_Mouse1.01788174
97SMAD4_21741376_ChIP-Seq_HESCs_Human1.01644121
98SMAD3_21741376_ChIP-Seq_HESCs_Human1.01150413
99SMAD3_21741376_ChIP-Seq_ESCs_Human1.00202777
100* RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98236293
101* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human0.97003659
102NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.96454982
103TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95979704
104PRDM14_21183938_ChIP-Seq_MESCs_Mouse0.95086244
105* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94650864
106CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.94331830
107CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.93830549
108* AHR_22903824_ChIP-Seq_MCF-7_Human0.93314557
109KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.91703246
110* ARNT_22903824_ChIP-Seq_MCF-7_Human0.91419025
111CTBP1_25329375_ChIP-Seq_LNCAP_Human0.91317602
112NANOG_16153702_ChIP-ChIP_HESCs_Human0.90264865
113* POU3F1_26484290_ChIP-Seq_ESCss_Mouse0.88737734
114SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.88483457
115SMAD3_21741376_ChIP-Seq_EPCs_Human0.88120078
116ZNF274_21170338_ChIP-Seq_K562_Hela0.88048726
117NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.87987168
118MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87705998
119TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.87616918
120P53_22127205_ChIP-Seq_FIBROBLAST_Human0.87231926
121STAT6_21828071_ChIP-Seq_BEAS2B_Human0.86189305
122* LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.86098512
123* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85485382
124POU5F1_18347094_ChIP-ChIP_MESCs_Mouse0.85392115
125NR3C1_23031785_ChIP-Seq_PC12_Mouse0.84910415
126* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.83405740
127DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82897558
128SALL1_21062744_ChIP-ChIP_HESCs_Human0.81425974

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003283_abnormal_digestive_organ3.86575655
2MP0010030_abnormal_orbit_morphology3.58498678
3MP0002653_abnormal_ependyma_morphology3.54253816
4MP0000537_abnormal_urethra_morphology3.29361327
5MP0000566_synostosis2.99644741
6MP0003011_delayed_dark_adaptation2.76846764
7MP0003122_maternal_imprinting2.64275051
8MP0000778_abnormal_nervous_system2.39137769
9MP0002234_abnormal_pharynx_morphology2.34711736
10MP0009053_abnormal_anal_canal2.32745949
11MP0003878_abnormal_ear_physiology2.30415965
12MP0005377_hearing/vestibular/ear_phenot2.30415965
13MP0002102_abnormal_ear_morphology2.26047691
14MP0005551_abnormal_eye_electrophysiolog2.23938790
15MP0006072_abnormal_retinal_apoptosis2.22930235
16MP0003938_abnormal_ear_development2.11977087
17MP0005253_abnormal_eye_physiology2.06347273
18MP0005623_abnormal_meninges_morphology2.02586419
19MP0002249_abnormal_larynx_morphology2.02201037
20MP0002697_abnormal_eye_size2.01422242
21MP0000049_abnormal_middle_ear2.00985989
22MP0004133_heterotaxia1.98352755
23MP0003942_abnormal_urinary_system1.97453216
24MP0003787_abnormal_imprinting1.95507257
25MP0003937_abnormal_limbs/digits/tail_de1.88723146
26MP0003121_genomic_imprinting1.84525298
27MP0002282_abnormal_trachea_morphology1.81063273
28MP0001293_anophthalmia1.80864509
29MP0004885_abnormal_endolymph1.79971397
30MP0005391_vision/eye_phenotype1.74162950
31MP0003123_paternal_imprinting1.72249929
32MP0009379_abnormal_foot_pigmentation1.70313167
33MP0000428_abnormal_craniofacial_morphol1.66228820
34MP0001984_abnormal_olfaction1.64106620
35MP0006292_abnormal_olfactory_placode1.63632641
36MP0003115_abnormal_respiratory_system1.62131667
37MP0005248_abnormal_Harderian_gland1.59399116
38MP0001286_abnormal_eye_development1.58685872
39MP0008789_abnormal_olfactory_epithelium1.54202954
40MP0003119_abnormal_digestive_system1.53314978
41MP0005195_abnormal_posterior_eye1.52539178
42MP0004272_abnormal_basement_membrane1.49753882
43MP0005499_abnormal_olfactory_system1.48756789
44MP0005394_taste/olfaction_phenotype1.48756789
45MP0003861_abnormal_nervous_system1.48147333
46MP0001299_abnormal_eye_distance/1.46989917
47MP0004858_abnormal_nervous_system1.46758002
48MP0002063_abnormal_learning/memory/cond1.45208761
49MP0003635_abnormal_synaptic_transmissio1.44777244
50MP0003890_abnormal_embryonic-extraembry1.42426267
51MP0006276_abnormal_autonomic_nervous1.42353895
52MP0003315_abnormal_perineum_morphology1.42297852
53MP0002932_abnormal_joint_morphology1.42094604
54MP0002822_catalepsy1.41584141
55MP0002092_abnormal_eye_morphology1.39713487
56MP0004233_abnormal_muscle_weight1.36024290
57MP0001324_abnormal_eye_pigmentation1.35374765
58MP0002557_abnormal_social/conspecific_i1.34510273
59MP0002116_abnormal_craniofacial_bone1.34485712
60MP0002233_abnormal_nose_morphology1.34336864
61MP0003755_abnormal_palate_morphology1.33053423
62MP0001486_abnormal_startle_reflex1.30265735
63MP0000026_abnormal_inner_ear1.27422986
64MP0001485_abnormal_pinna_reflex1.26548382
65MP0003935_abnormal_craniofacial_develop1.25880610
66MP0008004_abnormal_stomach_pH1.24037343
67MP0004270_analgesia1.20945243
68MP0001502_abnormal_circadian_rhythm1.20197131
69MP0000534_abnormal_ureter_morphology1.18791275
70MP0002938_white_spotting1.18768088
71MP0002572_abnormal_emotion/affect_behav1.18243512
72MP0002752_abnormal_somatic_nervous1.16872817
73MP0003385_abnormal_body_wall1.15672886
74MP0002084_abnormal_developmental_patter1.15428152
75MP0000383_abnormal_hair_follicle1.14625571
76MP0000462_abnormal_digestive_system1.12457058
77MP0004084_abnormal_cardiac_muscle1.12285744
78MP0002751_abnormal_autonomic_nervous1.12230873
79MP0002272_abnormal_nervous_system1.10846962
80MP0004811_abnormal_neuron_physiology1.09973411
81MP0000631_abnormal_neuroendocrine_gland1.09892086
82MP0002734_abnormal_mechanical_nocicepti1.09709936
83MP0001346_abnormal_lacrimal_gland1.09368232
84MP0002085_abnormal_embryonic_tissue1.08508342
85MP0001963_abnormal_hearing_physiology1.07950682
86MP0005423_abnormal_somatic_nervous1.07474558
87MP0009780_abnormal_chondrocyte_physiolo1.07379964
88MP0002152_abnormal_brain_morphology1.06989131
89MP0005197_abnormal_uvea_morphology1.05877863
90MP0005187_abnormal_penis_morphology1.02407717
91MP0004859_abnormal_synaptic_plasticity1.01050274
92MP0004142_abnormal_muscle_tone0.99232791
93MP0009250_abnormal_appendicular_skeleto0.98998010
94MP0001529_abnormal_vocalization0.97542776
95MP0000569_abnormal_digit_pigmentation0.97164541
96MP0004742_abnormal_vestibular_system0.97051224
97MP0002882_abnormal_neuron_morphology0.97026338
98MP0002064_seizures0.96811915
99MP0008961_abnormal_basal_metabolism0.96036663
100MP0003136_yellow_coat_color0.94997291
101MP0010368_abnormal_lymphatic_system0.94747275
102MP0009745_abnormal_behavioral_response0.93094301
103MP0000955_abnormal_spinal_cord0.92665357
104MP0002735_abnormal_chemical_nociception0.92432659
105MP0003634_abnormal_glial_cell0.89773178
106MP0002090_abnormal_vision0.89346430
107MP0000579_abnormal_nail_morphology0.88902812
108MP0000467_abnormal_esophagus_morphology0.88657840
109MP0002638_abnormal_pupillary_reflex0.86965066
110MP0002067_abnormal_sensory_capabilities0.85750862
111MP0001970_abnormal_pain_threshold0.84614829
112MP0002081_perinatal_lethality0.84072378
113MP0002111_abnormal_tail_morphology0.82593162
114MP0010678_abnormal_skin_adnexa0.82221464
115MP0003880_abnormal_central_pattern0.82207873
116MP0000762_abnormal_tongue_morphology0.81569882
117MP0005076_abnormal_cell_differentiation0.81516224
118MP0002909_abnormal_adrenal_gland0.81343435
119MP0004197_abnormal_fetal_growth/weight/0.81255400
120MP0008932_abnormal_embryonic_tissue0.80180328
121MP0000432_abnormal_head_morphology0.78243499
122MP0003329_amyloid_beta_deposits0.77987798
123MP0002089_abnormal_postnatal_growth/wei0.77235258
124MP0002733_abnormal_thermal_nociception0.77163313
125MP0002109_abnormal_limb_morphology0.76838610
126MP0003567_abnormal_fetal_cardiomyocyte0.75656134
127MP0001188_hyperpigmentation0.75324384
128MP0001968_abnormal_touch/_nociception0.75151360
129MP0000163_abnormal_cartilage_morphology0.74726051
130MP0002127_abnormal_cardiovascular_syste0.74296728
131MP0002184_abnormal_innervation0.74068846
132MP0003137_abnormal_impulse_conducting0.70240088
133MP0002114_abnormal_axial_skeleton0.69314515
134MP0001915_intracranial_hemorrhage0.69296172
135MP0003941_abnormal_skin_development0.67534185
136MP0005257_abnormal_intraocular_pressure0.67514537
137MP0005193_abnormal_anterior_eye0.66940395

Predicted human phenotypes

RankGene SetZ-score
1Bilateral microphthalmos (HP:0007633)4.29609717
2Abnormal respiratory motile cilium physiology (HP:0012261)3.75461487
3Anophthalmia (HP:0000528)3.71432420
4Abnormal ciliary motility (HP:0012262)3.65518936
5Mesangial abnormality (HP:0001966)3.55046153
6Central scotoma (HP:0000603)3.50749616
7Abnormality of the diencephalon (HP:0010662)3.32780510
8Bony spicule pigmentary retinopathy (HP:0007737)3.25996198
9Abnormal number of incisors (HP:0011064)3.24519010
10Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.17339405
11Rib fusion (HP:0000902)3.16810458
12Scotoma (HP:0000575)3.12101418
13Congenital stationary night blindness (HP:0007642)3.12086983
14True hermaphroditism (HP:0010459)3.08591275
15Pendular nystagmus (HP:0012043)3.02736274
16Neonatal short-limb short stature (HP:0008921)2.98927286
17Renal duplication (HP:0000075)2.98860744
18Focal segmental glomerulosclerosis (HP:0000097)2.98752926
19Chorioretinal atrophy (HP:0000533)2.97720291
20Turricephaly (HP:0000262)2.93322992
21Maternal diabetes (HP:0009800)2.90363976
22Aplasia involving bones of the upper limbs (HP:0009823)2.89642778
23Abnormality of the 4th metacarpal (HP:0010012)2.88817717
24Myokymia (HP:0002411)2.85657189
25Abnormal respiratory epithelium morphology (HP:0012253)2.83890712
26Abnormal respiratory motile cilium morphology (HP:0005938)2.83890712
27Concave nail (HP:0001598)2.77563282
28Stage 5 chronic kidney disease (HP:0003774)2.68216959
29Absent septum pellucidum (HP:0001331)2.68041560
30Coronal craniosynostosis (HP:0004440)2.65698965
31Overriding aorta (HP:0002623)2.60730354
32Occipital encephalocele (HP:0002085)2.57720556
33Abnormality of macular pigmentation (HP:0008002)2.55080474
34Keratoconus (HP:0000563)2.54954316
35Increased corneal curvature (HP:0100692)2.54954316
36Rhinitis (HP:0012384)2.54293657
37Optic nerve hypoplasia (HP:0000609)2.52726562
38Tubular atrophy (HP:0000092)2.51239696
39Cutaneous finger syndactyly (HP:0010554)2.50223623
40Dyschromatopsia (HP:0007641)2.48454176
41Abolished electroretinogram (ERG) (HP:0000550)2.47512628
42Broad thumb (HP:0011304)2.46282297
43Septo-optic dysplasia (HP:0100842)2.45379086
44Supernumerary spleens (HP:0009799)2.41247420
45Abnormal rod and cone electroretinograms (HP:0008323)2.40552228
46Glomerulosclerosis (HP:0000096)2.39757613
47Cutaneous syndactyly (HP:0012725)2.38679161
48Megalencephaly (HP:0001355)2.35255473
49Esophageal atresia (HP:0002032)2.33175890
50Sclerocornea (HP:0000647)2.32252668
51Renovascular hypertension (HP:0100817)2.31737000
52Hypoalbuminemia (HP:0003073)2.30209125
53Abnormal albumin level (HP:0012116)2.30209125
54Dynein arm defect of respiratory motile cilia (HP:0012255)2.29084370
55Absent/shortened dynein arms (HP:0200106)2.29084370
56Preaxial foot polydactyly (HP:0001841)2.26187824
57Broad phalanges of the hand (HP:0009768)2.24627829
58Hypoplasia of the ulna (HP:0003022)2.24102412
59Pancreatic fibrosis (HP:0100732)2.23195496
60Preaxial hand polydactyly (HP:0001177)2.23039003
61Oligodactyly (HP:0012165)2.22725545
62Hyperacusis (HP:0010780)2.22524939
63Hepatoblastoma (HP:0002884)2.22257531
64Elfin facies (HP:0004428)2.20565773
65Broad finger (HP:0001500)2.18578844
66Anencephaly (HP:0002323)2.17072091
67Abnormality of the septum pellucidum (HP:0007375)2.13481237
68Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.12899517
69Broad long bones (HP:0005622)2.12240759
70Broad phalanx (HP:0006009)2.11688691
71Bifid tongue (HP:0010297)2.10346326
72Truncus arteriosus (HP:0001660)2.09577081
73Flat cornea (HP:0007720)2.09438469
74Midline defect of the nose (HP:0004122)2.08729421
75Tented upper lip vermilion (HP:0010804)2.08576490
76Decreased central vision (HP:0007663)2.07548733
77Abnormality of the ischium (HP:0003174)2.07538032
78Abnormality of the phalanges of the 2nd finger (HP:0009541)2.06681267
79Congenital primary aphakia (HP:0007707)2.06386080
80Myelomeningocele (HP:0002475)2.06366358
81Oligodactyly (hands) (HP:0001180)2.05937830
82Hemivertebrae (HP:0002937)2.03176786
83Synostosis of carpal bones (HP:0005048)2.02380140
84Missing ribs (HP:0000921)2.01783740
85Abnormality of the antihelix (HP:0009738)2.01496407
86Aqueductal stenosis (HP:0002410)2.01389278
87Postaxial foot polydactyly (HP:0001830)2.00462777
88Short 4th metacarpal (HP:0010044)1.99859075
89Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.99859075
90Abnormal biliary tract physiology (HP:0012439)1.99513661
91Bile duct proliferation (HP:0001408)1.99513661
92Fibular hypoplasia (HP:0003038)1.95522514
93Renal dysplasia (HP:0000110)1.93966867
94Annular pancreas (HP:0001734)1.93810884
95Bronchomalacia (HP:0002780)1.93747830
96Supernumerary ribs (HP:0005815)1.93436487
97Anomalous pulmonary venous return (HP:0010772)1.93280018
98Broad distal phalanx of finger (HP:0009836)1.92786319
99Wide anterior fontanel (HP:0000260)1.92307382
100Megalocornea (HP:0000485)1.92292092
101Abnormality of the aortic arch (HP:0012303)1.92124591
102Insomnia (HP:0100785)1.90788858
103Mixed hearing impairment (HP:0000410)1.90668960
104Severe visual impairment (HP:0001141)1.89591624
105Thin ribs (HP:0000883)1.89534153
106Broad toe (HP:0001837)1.88744948
107Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88053349
108Pigmentary retinal degeneration (HP:0001146)1.87904681
109Vitreoretinal degeneration (HP:0000655)1.87716302
110Morphological abnormality of the inner ear (HP:0011390)1.86405242
111Duplication of thumb phalanx (HP:0009942)1.85814545
112Trigonocephaly (HP:0000243)1.85614307
113Hypoplastic ischia (HP:0003175)1.85238183
114Hypoplastic pelvis (HP:0008839)1.85047098
115Pseudobulbar signs (HP:0002200)1.84880988
116Tracheomalacia (HP:0002779)1.84308328
117Partial duplication of thumb phalanx (HP:0009944)1.82738380
118Split foot (HP:0001839)1.82120390
119Growth hormone deficiency (HP:0000824)1.81622048
120Back pain (HP:0003418)1.80880307
121Shallow orbits (HP:0000586)1.80811817
122Renal hypoplasia (HP:0000089)1.80573646
123Vaginal atresia (HP:0000148)1.80126932
124Abnormality of the incisor (HP:0000676)1.78794043
125Absent epiphyses (HP:0010577)1.78684275
126Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.78684275
127Partial duplication of the phalanx of hand (HP:0009999)1.77672193
128Holoprosencephaly (HP:0001360)1.77194968
129Nuclear cataract (HP:0100018)1.77012933
130Abnormality of cochlea (HP:0000375)1.76784549
131Intestinal atresia (HP:0011100)1.76393762
132Omphalocele (HP:0001539)1.76310659
133Aplasia/Hypoplasia of the ulna (HP:0006495)1.76226691
134Broad hallux (HP:0010055)1.75738829
135Abnormality of chromosome segregation (HP:0002916)1.75734557
136Meningocele (HP:0002435)1.74802848
137Skull defect (HP:0001362)1.74319173
138Arnold-Chiari malformation (HP:0002308)1.74212109
139Ectopic anus (HP:0004397)1.74071690
140Morphological abnormality of the middle ear (HP:0008609)1.73651582
141Supernumerary bones of the axial skeleton (HP:0009144)1.73618915
142Abnormality of the intervertebral disk (HP:0005108)1.73141379
143Genital tract atresia (HP:0001827)1.72724027
144Cystic liver disease (HP:0006706)1.72405702
145Pointed chin (HP:0000307)1.72181628
146Abnormal lung lobation (HP:0002101)1.72049867
147Nephrotic syndrome (HP:0000100)1.71812785
148Gastrointestinal atresia (HP:0002589)1.71763868
149Reticulocytopenia (HP:0001896)1.71642546
150Aplasia/Hypoplasia of the lens (HP:0008063)1.70734908
151Patellar dislocation (HP:0002999)1.70706686
152Abnormality of dentin (HP:0010299)1.70698340
153Abnormality of permanent molar morphology (HP:0011071)1.70345562
154Abnormality of the dental root (HP:0006486)1.70345562
155Taurodontia (HP:0000679)1.70345562
156Bicornuate uterus (HP:0000813)1.68915168
157Pancreatic cysts (HP:0001737)1.68173795
158Facial hemangioma (HP:0000329)1.67010744
159High anterior hairline (HP:0009890)1.65923728
160Ridged nail (HP:0001807)1.65508188
161Gait imbalance (HP:0002141)1.65377131
162Abnormality of the 2nd finger (HP:0004100)1.64466977
163Nephronophthisis (HP:0000090)1.63864763
164Type II diabetes mellitus (HP:0005978)1.63330332
165Cone-rod dystrophy (HP:0000548)1.62578105
166Double outlet right ventricle (HP:0001719)1.62464129
167Congenital malformation of the right heart (HP:0011723)1.62464129
168Attenuation of retinal blood vessels (HP:0007843)1.62419376
169Abnormality of the lower motor neuron (HP:0002366)1.62254099
170Hypotelorism (HP:0000601)1.62233311
171Aplasia of the phalanges of the hand (HP:0009802)1.62121800
172Aplasia involving bones of the extremities (HP:0009825)1.62121800
173Broad palm (HP:0001169)1.61465402
174Sleep apnea (HP:0010535)1.60919648
175Broad metatarsal (HP:0001783)1.60813380

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHB26.21394374
2KSR14.10152066
3CASK2.97844196
4EPHA42.96595114
5MAP3K102.73878620
6PASK2.61095155
7SIK32.58988481
8BCR2.51843143
9PNCK2.36692688
10CDK122.28558049
11GRK12.26949273
12TNIK2.19777010
13PAK42.16875232
14ERBB21.93109034
15CDK191.71464196
16MAP3K41.68243915
17MAPK151.62994547
18ICK1.56344279
19UHMK11.52493564
20RIPK11.50059709
21MARK11.41536759
22EPHA31.40288669
23MAP3K91.39643680
24NTRK21.38484453
25FGFR11.36390167
26MAP2K71.35963633
27LATS11.35170504
28BRD41.35031886
29ROCK21.33441120
30SGK2231.33011838
31SGK4941.33011838
32FGFR21.32355584
33PLK41.28533874
34CAMK1G1.28247983
35BUB11.28213128
36CDC71.24194817
37IRAK21.20507727
38MINK11.18015367
39LATS21.14463404
40STK391.13966257
41TYRO31.11112095
42MKNK11.10504903
43PRKCG1.10342917
44CSNK1G21.08704606
45SIK11.08177830
46TGFBR11.07560611
47NEK11.07441167
48WNK41.06892716
49CDC42BPA1.06472420
50PAK61.05068970
51NEK61.05063644
52CDK51.01179097
53ERBB30.99362221
54STK110.97780629
55MAP2K40.97569919
56PINK10.96466703
57CDK180.96083671
58PRKCH0.94090019
59PAK20.93755567
60WNK10.93493871
61ROCK10.92851859
62MOS0.92845683
63BRSK10.90896185
64MARK20.90529150
65OBSCN0.89799462
66AKT20.88261756
67WEE10.86990351
68SGK20.86877329
69PTK60.85432057
70CCNB10.82429080
71TSSK60.80945566
72CDK150.80867935
73PDGFRA0.80470713
74SRPK10.79413712
75CDK80.78856495
76CHEK20.78569838
77CDK11A0.75118978
78TTK0.74626121
79LRRK20.74230738
80PAK30.73720110
81DMPK0.72465901
82CDK140.72138175
83OXSR10.71741280
84LIMK10.70681107
85EEF2K0.69949427
86RPS6KC10.68154265
87RPS6KL10.68154265
88SIK20.68055700
89RPS6KA20.67815739
90PLK30.67424308
91MKNK20.65504145
92PLK10.64893903
93RPS6KA60.63149516
94DYRK1B0.62598459
95MELK0.62547117
96SGK30.62502055
97MTOR0.62168797
98DYRK1A0.62144148
99PRKD30.62105144
100WNK30.61599472
101PKN20.59719822
102NTRK10.59181825
103BRAF0.58624020
104CAMK1D0.58622543
105MAPK90.58301379
106PTK20.57677410
107NTRK30.57143294
108AURKA0.55228581
109CHEK10.55139613
110ARAF0.52928342
111TLK10.52905119
112CSNK1D0.52458297
113MAPK130.52428956
114CDK70.51909721
115CDK10.51869303
116SRC0.50662856
117CAMK10.50599267
118CSNK1E0.50426874
119ATR0.50031033
120ADRBK10.49469173
121PLK20.49193283
122STK38L0.48447231
123TRIB30.47780034
124RET0.47176437
125CSNK1G30.47000912
126ALK0.46244821
127CSNK1G10.45661232
128PKN10.45266788
129CAMK2B0.44974030
130NEK20.44969218
131CAMKK10.44257997
132PIK3CA0.44174131
133AKT10.44139568
134PRKDC0.43772430
135FGFR40.43486560
136CDK20.42727196
137PRKCZ0.42570465
138MAPK100.42206294
139AURKB0.42056661
140FGFR30.42003167
141DYRK30.41875855
142PHKG20.39974130
143PHKG10.39974130
144PDGFRB0.39685344
145SGK10.39674880
146DYRK20.39490816
147CSNK1A1L0.38793158
148GSK3B0.37834699

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047445.05356894
2Basal cell carcinoma_Homo sapiens_hsa052174.49407064
3Hedgehog signaling pathway_Homo sapiens_hsa043403.59049019
4* Hippo signaling pathway_Homo sapiens_hsa043903.02251157
5Axon guidance_Homo sapiens_hsa043602.85002811
6Notch signaling pathway_Homo sapiens_hsa043302.52632463
7Wnt signaling pathway_Homo sapiens_hsa043102.19978709
8Ribosome_Homo sapiens_hsa030102.13962773
9Melanogenesis_Homo sapiens_hsa049161.98142009
10Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.92329402
11Spliceosome_Homo sapiens_hsa030401.76463194
12mRNA surveillance pathway_Homo sapiens_hsa030151.53361837
13Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.49286557
14Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.46329925
15Tight junction_Homo sapiens_hsa045301.45875896
16MicroRNAs in cancer_Homo sapiens_hsa052061.42040975
17Cell cycle_Homo sapiens_hsa041101.40726624
18DNA replication_Homo sapiens_hsa030301.35681577
19Base excision repair_Homo sapiens_hsa034101.33376834
20Adherens junction_Homo sapiens_hsa045201.31545720
21Proteoglycans in cancer_Homo sapiens_hsa052051.28952337
22Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.26048739
23Oocyte meiosis_Homo sapiens_hsa041141.19190243
24Dilated cardiomyopathy_Homo sapiens_hsa054141.18710641
25Renal cell carcinoma_Homo sapiens_hsa052111.17413834
26Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13855264
27ECM-receptor interaction_Homo sapiens_hsa045121.13802749
28Pathways in cancer_Homo sapiens_hsa052001.11010090
29GABAergic synapse_Homo sapiens_hsa047271.09551330
30Small cell lung cancer_Homo sapiens_hsa052221.08261485
31Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.06570716
32Dorso-ventral axis formation_Homo sapiens_hsa043201.06001240
33Mismatch repair_Homo sapiens_hsa034301.04627219
34Gap junction_Homo sapiens_hsa045401.03285368
35Focal adhesion_Homo sapiens_hsa045101.02840692
36Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.01879497
37Circadian entrainment_Homo sapiens_hsa047131.00757815
38TGF-beta signaling pathway_Homo sapiens_hsa043500.99912928
39Nicotine addiction_Homo sapiens_hsa050330.97951297
40Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.96678846
41Bladder cancer_Homo sapiens_hsa052190.95088189
42Central carbon metabolism in cancer_Homo sapiens_hsa052300.94576489
43Phospholipase D signaling pathway_Homo sapiens_hsa040720.94312703
44Steroid biosynthesis_Homo sapiens_hsa001000.93767471
45Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92197795
46HTLV-I infection_Homo sapiens_hsa051660.90916459
47Colorectal cancer_Homo sapiens_hsa052100.89280684
48Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.88558807
49Nucleotide excision repair_Homo sapiens_hsa034200.87729693
50Glutamatergic synapse_Homo sapiens_hsa047240.86081586
51mTOR signaling pathway_Homo sapiens_hsa041500.83148049
52Amphetamine addiction_Homo sapiens_hsa050310.82459549
53Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.82112055
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.81869018
55Endometrial cancer_Homo sapiens_hsa052130.81721355
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.80905503
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.80332420
58Lysine degradation_Homo sapiens_hsa003100.80076257
59Ras signaling pathway_Homo sapiens_hsa040140.79953597
60Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.78964589
61Olfactory transduction_Homo sapiens_hsa047400.78450740
62Cardiac muscle contraction_Homo sapiens_hsa042600.77927485
63Neurotrophin signaling pathway_Homo sapiens_hsa047220.76496235
64cGMP-PKG signaling pathway_Homo sapiens_hsa040220.76289876
65Dopaminergic synapse_Homo sapiens_hsa047280.76263223
66Cocaine addiction_Homo sapiens_hsa050300.74908421
67Oxytocin signaling pathway_Homo sapiens_hsa049210.74246527
68AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.73449934
69Gastric acid secretion_Homo sapiens_hsa049710.72827234
70Rap1 signaling pathway_Homo sapiens_hsa040150.72810923
71Glioma_Homo sapiens_hsa052140.71491622
72Morphine addiction_Homo sapiens_hsa050320.70386722
73Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.70296528
74Taste transduction_Homo sapiens_hsa047420.69554259
75Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.69426215
76Long-term depression_Homo sapiens_hsa047300.69410050
77Thyroid hormone synthesis_Homo sapiens_hsa049180.69239310
78Sulfur relay system_Homo sapiens_hsa041220.67998311
79RNA transport_Homo sapiens_hsa030130.67686433
80Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.67603210
81Synaptic vesicle cycle_Homo sapiens_hsa047210.66435535
82Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66315012
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.65514347
84Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.64949579
85alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.64351522
86Bile secretion_Homo sapiens_hsa049760.63777612
87Viral myocarditis_Homo sapiens_hsa054160.63654690
88Fanconi anemia pathway_Homo sapiens_hsa034600.63491278
89Insulin secretion_Homo sapiens_hsa049110.62559161
90Alcoholism_Homo sapiens_hsa050340.62104072
91Cholinergic synapse_Homo sapiens_hsa047250.62037114
92Choline metabolism in cancer_Homo sapiens_hsa052310.61941525
93Estrogen signaling pathway_Homo sapiens_hsa049150.60049482
94VEGF signaling pathway_Homo sapiens_hsa043700.59839452
95Protein digestion and absorption_Homo sapiens_hsa049740.58493196
96N-Glycan biosynthesis_Homo sapiens_hsa005100.57024282
97Carbohydrate digestion and absorption_Homo sapiens_hsa049730.56614434
98cAMP signaling pathway_Homo sapiens_hsa040240.56216276
99Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.54970830
100PI3K-Akt signaling pathway_Homo sapiens_hsa041510.54951800
101MAPK signaling pathway_Homo sapiens_hsa040100.54771717
102Regulation of actin cytoskeleton_Homo sapiens_hsa048100.54275859
103Melanoma_Homo sapiens_hsa052180.54149731
104GnRH signaling pathway_Homo sapiens_hsa049120.53808008
105Prion diseases_Homo sapiens_hsa050200.53248589
106Ovarian steroidogenesis_Homo sapiens_hsa049130.52991392
107Calcium signaling pathway_Homo sapiens_hsa040200.51943806
108ErbB signaling pathway_Homo sapiens_hsa040120.50817667
109Non-small cell lung cancer_Homo sapiens_hsa052230.50136584
110Serotonergic synapse_Homo sapiens_hsa047260.50020267
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49331700
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47816150
113Prostate cancer_Homo sapiens_hsa052150.47570110
114Long-term potentiation_Homo sapiens_hsa047200.47059062
115Renin secretion_Homo sapiens_hsa049240.46772137
116Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.46674497
117Type II diabetes mellitus_Homo sapiens_hsa049300.46453168
118Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.45503536
119Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.45104822
120Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.43944672
121Chronic myeloid leukemia_Homo sapiens_hsa052200.43070790
122Inositol phosphate metabolism_Homo sapiens_hsa005620.41862166
123Circadian rhythm_Homo sapiens_hsa047100.40692954
124Salivary secretion_Homo sapiens_hsa049700.40595761
125Aldosterone synthesis and secretion_Homo sapiens_hsa049250.40562968
126Pancreatic cancer_Homo sapiens_hsa052120.40246938
127Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39919067
128Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39437980
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.38895201
130Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34974608
131Nitrogen metabolism_Homo sapiens_hsa009100.33338400

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