CRB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the Crumbs family of proteins. This gene is widely expressed in epithelial tissues where the encoded protein isoforms play various roles such as the control of cytokinesis and ciliogenesis or the formation of tight junctions. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1desmosome organization (GO:0002934)6.78531229
2establishment of skin barrier (GO:0061436)5.54591895
3bundle of His cell to Purkinje myocyte communication (GO:0086069)5.48031775
4intestinal epithelial cell development (GO:0060576)5.32408577
5folic acid metabolic process (GO:0046655)5.27651115
6keratinization (GO:0031424)5.01940259
7mitotic metaphase plate congression (GO:0007080)4.81658391
8multicellular organismal water homeostasis (GO:0050891)4.72547152
9purine nucleobase biosynthetic process (GO:0009113)4.62755936
10vitamin transmembrane transport (GO:0035461)4.50438908
11folic acid transport (GO:0015884)4.17928013
12serine family amino acid catabolic process (GO:0009071)4.17015763
13keratinocyte development (GO:0003334)4.16425922
14protein autoprocessing (GO:0016540)4.13005309
15ribosome assembly (GO:0042255)4.03351014
16water homeostasis (GO:0030104)3.98776350
17nucleobase biosynthetic process (GO:0046112)3.95760113
18glycine metabolic process (GO:0006544)3.94861599
19cysteine metabolic process (GO:0006534)3.75837876
20regulation of cell-cell adhesion mediated by cadherin (GO:2000047)3.75620156
21modified amino acid transport (GO:0072337)3.68039810
22metaphase plate congression (GO:0051310)3.67092707
23uronic acid metabolic process (GO:0006063)3.56118820
24glucuronate metabolic process (GO:0019585)3.56118820
25cellular glucuronidation (GO:0052695)3.55175866
26intestinal absorption (GO:0050892)3.48011842
27vitamin transport (GO:0051180)3.47337434
28serine family amino acid metabolic process (GO:0009069)3.45188201
29UDP-N-acetylglucosamine metabolic process (GO:0006047)3.43571701
30phospholipid efflux (GO:0033700)3.41520400
31regulation of transforming growth factor beta1 production (GO:0032908)3.39277084
32sulfur amino acid catabolic process (GO:0000098)3.38207798
33sphingomyelin metabolic process (GO:0006684)3.37591554
34intestinal cholesterol absorption (GO:0030299)3.32617727
35regulation of cholesterol esterification (GO:0010872)3.31039170
36pyrimidine-containing compound transmembrane transport (GO:0072531)3.28339631
37epoxygenase P450 pathway (GO:0019373)3.27575952
38DNA deamination (GO:0045006)3.25851009
39rRNA modification (GO:0000154)3.24819470
40regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.24146565
41regulation of spindle organization (GO:0090224)3.22567087
42positive regulation of cellular amine metabolic process (GO:0033240)3.22007700
43flavonoid metabolic process (GO:0009812)3.18546908
44interferon-gamma secretion (GO:0072643)3.16047575
45transcription elongation from RNA polymerase III promoter (GO:0006385)3.15276450
46termination of RNA polymerase III transcription (GO:0006386)3.15276450
47proline metabolic process (GO:0006560)3.10341489
48negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)3.10218632
49ribosomal large subunit biogenesis (GO:0042273)3.10116290
50pantothenate metabolic process (GO:0015939)3.09931191
51urea cycle (GO:0000050)3.08166404
52serine family amino acid biosynthetic process (GO:0009070)3.03614383
53urea metabolic process (GO:0019627)3.02288828
54phenylpropanoid metabolic process (GO:0009698)3.01456245
55nucleotide-sugar biosynthetic process (GO:0009226)3.00988346
56regulation of Wnt signaling pathway involved in heart development (GO:0003307)3.00829962
57formation of translation preinitiation complex (GO:0001731)3.00397843
58glutathione biosynthetic process (GO:0006750)2.99493611
59gap junction assembly (GO:0016264)2.98449104
60L-phenylalanine metabolic process (GO:0006558)2.96298000
61erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.96298000
624-hydroxyproline metabolic process (GO:0019471)2.95418264
63sulfur amino acid biosynthetic process (GO:0000097)2.95209464
64urate metabolic process (GO:0046415)2.94975463
65regulation of bile acid biosynthetic process (GO:0070857)2.94814123
66proteasome assembly (GO:0043248)2.93634535
67S-adenosylmethionine metabolic process (GO:0046500)2.92270156
68negative regulation of translational initiation (GO:0045947)2.91118778
69L-methionine salvage (GO:0071267)2.90093146
70L-methionine biosynthetic process (GO:0071265)2.90093146
71amino acid salvage (GO:0043102)2.90093146
72GDP-mannose metabolic process (GO:0019673)2.89104326
73very-low-density lipoprotein particle assembly (GO:0034379)2.88428653
74ribosome biogenesis (GO:0042254)2.86954952
75drug catabolic process (GO:0042737)2.86921984
76DNA replication checkpoint (GO:0000076)2.86560871
77homocysteine metabolic process (GO:0050667)2.85651966
78regulation of keratinocyte proliferation (GO:0010837)2.85543577
79L-ascorbic acid metabolic process (GO:0019852)2.85255750
80regulation of metalloenzyme activity (GO:0048552)2.84127420
81maturation of SSU-rRNA (GO:0030490)2.83521954
82* tight junction assembly (GO:0070830)2.83361281
83fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)2.82980365
84primary alcohol catabolic process (GO:0034310)2.82811752
85ectoderm development (GO:0007398)2.80581825
86folic acid-containing compound metabolic process (GO:0006760)2.79881129
87sulfur amino acid metabolic process (GO:0000096)2.78545229
88keratinocyte proliferation (GO:0043616)2.78192560
89regulation of cholesterol homeostasis (GO:2000188)2.77693290
90drug metabolic process (GO:0017144)2.76809676
91branching involved in labyrinthine layer morphogenesis (GO:0060670)2.75529802
92regulation of cell proliferation involved in kidney development (GO:1901722)2.75465669
93COPI coating of Golgi vesicle (GO:0048205)2.73763802
94Golgi transport vesicle coating (GO:0048200)2.73763802
95L-phenylalanine catabolic process (GO:0006559)2.69752284
96erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.69752284
97glandular epithelial cell differentiation (GO:0002067)2.69203624
98regulation of translation in response to stress (GO:0043555)2.69147521
99regulation of hippo signaling (GO:0035330)2.69127724
100nitrogen cycle metabolic process (GO:0071941)2.68665612
1017-methylguanosine mRNA capping (GO:0006370)2.67521039
102nonribosomal peptide biosynthetic process (GO:0019184)2.66001639
103establishment of chromosome localization (GO:0051303)2.65191763
104lung-associated mesenchyme development (GO:0060484)2.65170171
105drug transmembrane transport (GO:0006855)2.64322378
106positive regulation of Cdc42 GTPase activity (GO:0043089)2.63604451
107inner cell mass cell proliferation (GO:0001833)2.63018012
108plasma lipoprotein particle assembly (GO:0034377)2.60530232
109negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.60153172
110negative regulation of DNA-templated transcription, elongation (GO:0032785)2.60153172
111regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.59881049
112NADH metabolic process (GO:0006734)2.59858107
113ribonucleoprotein complex biogenesis (GO:0022613)2.59850978
114folic acid-containing compound biosynthetic process (GO:0009396)2.59717665
115pteridine-containing compound metabolic process (GO:0042558)2.59336489
116negative regulation of lipase activity (GO:0060192)2.58332367
117methionine metabolic process (GO:0006555)2.57432957
118regulation of water loss via skin (GO:0033561)2.57111892
119drug transport (GO:0015893)2.56201069
120positive regulation of keratinocyte differentiation (GO:0045618)2.56151852
121high-density lipoprotein particle remodeling (GO:0034375)2.55936101
122anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.53397254
123regulation of keratinocyte differentiation (GO:0045616)2.52875098
124negative regulation of transcription by competitive promoter binding (GO:0010944)2.52501305
125biotin metabolic process (GO:0006768)2.52030136
126transcription from RNA polymerase I promoter (GO:0006360)2.51725149
1277-methylguanosine RNA capping (GO:0009452)2.51488032
128RNA capping (GO:0036260)2.51488032
129maturation of 5.8S rRNA (GO:0000460)2.51214065
130positive regulation of epidermis development (GO:0045684)2.51127927
131amino-acid betaine metabolic process (GO:0006577)2.50712647
132fructose metabolic process (GO:0006000)2.49435876
133termination of RNA polymerase I transcription (GO:0006363)2.49292485
134calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.49253241
135surfactant homeostasis (GO:0043129)2.48939620
136rRNA methylation (GO:0031167)2.48836409
137protein K6-linked ubiquitination (GO:0085020)2.48746805
138regulation of cardioblast differentiation (GO:0051890)2.47557392
139regulation of cellular amino acid metabolic process (GO:0006521)2.47155623
140cobalamin metabolic process (GO:0009235)2.46139802
141regulation of mitotic spindle organization (GO:0060236)2.45546261
142purine ribonucleotide transport (GO:0015868)2.45053162
143diterpenoid biosynthetic process (GO:0016102)2.45047088
144proline biosynthetic process (GO:0006561)2.45004968
145pteridine-containing compound biosynthetic process (GO:0042559)2.44271956
146heme transport (GO:0015886)2.43982880
147excretion (GO:0007588)2.43981708
148protein localization to kinetochore (GO:0034501)2.42612588
149columnar/cuboidal epithelial cell development (GO:0002066)2.41795371
150carbohydrate derivative transport (GO:1901264)2.41746606
151methionine biosynthetic process (GO:0009086)2.41709829
152regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.41657873
153positive regulation of epidermal cell differentiation (GO:0045606)2.41388550
154transcytosis (GO:0045056)2.41077933
155regulation of G0 to G1 transition (GO:0070316)2.41055230
156positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.40988196
157negative regulation of keratinocyte proliferation (GO:0010839)2.40620317
158positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)2.40236446
159response to food (GO:0032094)2.39497626
160labyrinthine layer development (GO:0060711)2.39416959
161blastocyst development (GO:0001824)2.38894630
162spindle checkpoint (GO:0031577)2.38175304
163phosphatidylserine acyl-chain remodeling (GO:0036150)2.37409948
164hemidesmosome assembly (GO:0031581)2.37251415
165bile acid and bile salt transport (GO:0015721)2.36788364
166trivalent inorganic anion homeostasis (GO:0072506)2.36273884
167phosphate ion homeostasis (GO:0055062)2.36273884
168ethanol metabolic process (GO:0006067)2.36252761
169positive regulation of hormone metabolic process (GO:0032352)2.35370946
170digestion (GO:0007586)2.33636482

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.42332835
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.13167308
3CDX2_20551321_ChIP-Seq_CACO-2_Human3.11901990
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.11523910
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.95045768
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.87402034
7SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.84777822
8CREB1_15753290_ChIP-ChIP_HEK293T_Human2.75674717
9TP63_17297297_ChIP-ChIP_HaCaT_Human2.74542668
10FOXM1_23109430_ChIP-Seq_U2OS_Human2.67267989
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.65345325
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.56583347
13AR_21909140_ChIP-Seq_LNCAP_Human2.55519174
14PPARA_22158963_ChIP-Seq_LIVER_Mouse2.48326434
15FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.44090299
16RXR_22158963_ChIP-Seq_LIVER_Mouse2.43820838
17TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.42458475
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38773863
19EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.37844242
20ZNF263_19887448_ChIP-Seq_K562_Human2.37581026
21MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28828727
22E2F7_22180533_ChIP-Seq_HELA_Human2.24029396
23EST1_17652178_ChIP-ChIP_JURKAT_Human2.22883936
24CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.22712692
25HIF1A_21447827_ChIP-Seq_MCF-7_Human2.16311609
26* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.06707006
27CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.98402633
28SOX2_20726797_ChIP-Seq_SW620_Human1.97675317
29P63_26484246_Chip-Seq_KERATINOCYTES_Human1.96487114
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.88095510
31GATA3_24758297_ChIP-Seq_MCF-7_Human1.87777913
32TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.84815354
33HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.83527857
34KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.82596964
35E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80396930
36RARG_19884340_ChIP-ChIP_MEFs_Mouse1.79715518
37MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79448977
38NELFA_20434984_ChIP-Seq_ESCs_Mouse1.78919876
39GABP_19822575_ChIP-Seq_HepG2_Human1.78539752
40XRN2_22483619_ChIP-Seq_HELA_Human1.76454601
41ESR1_20079471_ChIP-ChIP_T-47D_Human1.75476464
42POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.74549041
43ESR1_15608294_ChIP-ChIP_MCF-7_Human1.72698141
44EGR1_23403033_ChIP-Seq_LIVER_Mouse1.70967171
45DCP1A_22483619_ChIP-Seq_HELA_Human1.69877688
46VDR_23849224_ChIP-Seq_CD4+_Human1.69084951
47FOXO3_23340844_ChIP-Seq_DLD1_Human1.63694493
48STAT3_1855785_ChIP-Seq_MESCs_Mouse1.63679676
49LXR_22158963_ChIP-Seq_LIVER_Mouse1.63358467
50STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.60801054
51CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60475133
52RUNX1_27514584_Chip-Seq_MCF-7_Human1.59549316
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.56025650
54KDM5A_27292631_Chip-Seq_BREAST_Human1.54604014
55BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.53564677
56MYCN_18555785_ChIP-Seq_MESCs_Mouse1.53139615
57PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.53137473
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52450089
59SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.52202110
60SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.52202110
61TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.51706972
62FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.50658575
63KAP1_22055183_ChIP-Seq_ESCs_Mouse1.46273597
64* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.44098607
65ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.42747117
66POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.41938058
67NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.40965899
68NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.39005465
69* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.38798164
70YY1_21170310_ChIP-Seq_MESCs_Mouse1.37681047
71KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.36636559
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.35084673
73GATA4_25053715_ChIP-Seq_YYC3_Human1.34035295
74KLF5_25053715_ChIP-Seq_YYC3_Human1.32761948
75ELF5_23300383_ChIP-Seq_T47D_Human1.31479456
76ZFX_18555785_ChIP-Seq_MESCs_Mouse1.29836952
77ATF3_27146783_Chip-Seq_COLON_Human1.29681072
78FOXP3_21729870_ChIP-Seq_TREG_Human1.29567254
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.28844284
80E2F4_17652178_ChIP-ChIP_JURKAT_Human1.28836127
81FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.28196801
82FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.27784179
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.26555182
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25074121
85GATA6_25053715_ChIP-Seq_YYC3_Human1.24036281
86HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.23180614
87ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.22353093
88TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22069907
89FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.20734064
90PPAR_26484153_Chip-Seq_NCI-H1993_Human1.20541796
91ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.20095367
92DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.18367537
93AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.17806702
94NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.15447410
95TET1_21451524_ChIP-Seq_MESCs_Mouse1.13294076
96LXR_22292898_ChIP-Seq_THP-1_Human1.12140604
97TCF3_18692474_ChIP-Seq_MEFs_Mouse1.11866288
98ELK1_22589737_ChIP-Seq_MCF10A_Human1.11056908
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.10634412
100TTF2_22483619_ChIP-Seq_HELA_Human1.10608340
101SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.09711043
102MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.09502615
103EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.06720221
104CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.06260302
105NANOG_21062744_ChIP-ChIP_HESCs_Human1.06072251
106SRF_21415370_ChIP-Seq_HL-1_Mouse1.05498191
107OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05240870
108HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.05122962
109NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.04782854
110TP63_22573176_ChIP-Seq_HFKS_Human1.04155891
111ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.04027620
112CREB1_26743006_Chip-Seq_LNCaP_Human1.03974652
113SOX2_18692474_ChIP-Seq_MEFs_Mouse1.01789113
114HNF4A_19822575_ChIP-Seq_HepG2_Human0.99975860
115FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.98669239
116TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.98490500
117ZNF217_24962896_ChIP-Seq_MCF-7_Human0.98046609
118E2F1_21310950_ChIP-Seq_MCF-7_Human0.97913534
119RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.97873801
120SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.96156474
121FOXA1_25552417_ChIP-Seq_VCAP_Human0.95212105
122RACK7_27058665_Chip-Seq_MCF-7_Human0.94588198
123SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.94103830
124ESR1_21235772_ChIP-Seq_MCF-7_Human0.93957332
125KAP1_27257070_Chip-Seq_ESCs_Mouse0.93723495
126SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93632702
127POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.93521410
128CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92419839
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.91537261
130CHD1_26751641_Chip-Seq_LNCaP_Human0.91431916
131* BCOR_27268052_Chip-Seq_Bcells_Human0.91323592
132SRY_22984422_ChIP-ChIP_TESTIS_Rat0.90358264
133CLOCK_20551151_ChIP-Seq_293T_Human0.89893463
134P68_20966046_ChIP-Seq_HELA_Human0.89574470
135ESR2_21235772_ChIP-Seq_MCF-7_Human0.89277161
136POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.89096758
137NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.89039959
138SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.88329379
139ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87871892
140HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.87859767
141THAP11_20581084_ChIP-Seq_MESCs_Mouse0.85376505
142NANOG_18692474_ChIP-Seq_MEFs_Mouse0.84554292
143KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.83230605
144SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.83025902
145CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.83005333

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.52780543
2MP0009840_abnormal_foam_cell4.35922034
3MP0002139_abnormal_hepatobiliary_system3.90246856
4MP0005360_urolithiasis3.84380243
5MP0005365_abnormal_bile_salt3.30485036
6MP0002254_reproductive_system_inflammat3.26095913
7MP0005085_abnormal_gallbladder_physiolo3.19424277
8MP0003718_maternal_effect3.03194406
9MP0005451_abnormal_body_composition2.91153716
10MP0004957_abnormal_blastocyst_morpholog2.74000022
11MP0001666_abnormal_nutrient_absorption2.72447339
12MP0010234_abnormal_vibrissa_follicle2.62333977
13MP0008875_abnormal_xenobiotic_pharmacok2.55616904
14MP0004264_abnormal_extraembryonic_tissu2.46118778
15MP0003111_abnormal_nucleus_morphology2.41304474
16MP0004019_abnormal_vitamin_homeostasis2.24500743
17MP0000462_abnormal_digestive_system2.10334832
18MP0003806_abnormal_nucleotide_metabolis2.07983800
19MP0000566_synostosis2.07846573
20MP0002876_abnormal_thyroid_physiology1.97183500
21MP0005332_abnormal_amino_acid1.94837119
22MP0003077_abnormal_cell_cycle1.76997463
23MP0005083_abnormal_biliary_tract1.76057600
24MP0009780_abnormal_chondrocyte_physiolo1.72863682
25MP0005220_abnormal_exocrine_pancreas1.63316572
26MP0005377_hearing/vestibular/ear_phenot1.63281374
27MP0003878_abnormal_ear_physiology1.63281374
28MP0009643_abnormal_urine_homeostasis1.62758083
29MP0002138_abnormal_hepatobiliary_system1.62345038
30MP0000467_abnormal_esophagus_morphology1.60665945
31MP0003191_abnormal_cellular_cholesterol1.57894803
32MP0004043_abnormal_pH_regulation1.55235237
33MP0010329_abnormal_lipoprotein_level1.55031035
34MP0001730_embryonic_growth_arrest1.51088194
35MP0004782_abnormal_surfactant_physiolog1.50344514
36MP0008260_abnormal_autophagy1.50104185
37MP0002796_impaired_skin_barrier1.47080741
38MP0001756_abnormal_urination1.46040532
39MP0003252_abnormal_bile_duct1.45807105
40MP0003123_paternal_imprinting1.38196127
41MP0010771_integument_phenotype1.35508465
42MP0005395_other_phenotype1.34136595
43MP0004381_abnormal_hair_follicle1.33254229
44MP0000427_abnormal_hair_cycle1.32597084
45MP0010094_abnormal_chromosome_stability1.32141962
46MP0003195_calcinosis1.28590756
47MP0003119_abnormal_digestive_system1.25954183
48MP0001764_abnormal_homeostasis1.20555640
49MP0002909_abnormal_adrenal_gland1.19542976
50MP0001881_abnormal_mammary_gland1.18465315
51MP0000609_abnormal_liver_physiology1.18101678
52MP0000490_abnormal_crypts_of1.16464482
53MP0003183_abnormal_peptide_metabolism1.15455904
54MP0003786_premature_aging1.14752176
55MP0001873_stomach_inflammation1.14617110
56MP0005084_abnormal_gallbladder_morpholo1.13679183
57MP0005380_embryogenesis_phenotype1.12816963
58MP0001672_abnormal_embryogenesis/_devel1.12816963
59MP0003941_abnormal_skin_development1.11902734
60MP0000647_abnormal_sebaceous_gland1.11608595
61MP0005636_abnormal_mineral_homeostasis1.09848720
62MP0002653_abnormal_ependyma_morphology1.07929089
63MP0002098_abnormal_vibrissa_morphology1.06582788
64MP0005408_hypopigmentation1.06189906
65MP0010352_gastrointestinal_tract_polyps1.06130265
66MP0008932_abnormal_embryonic_tissue1.04400404
67MP0002132_abnormal_respiratory_system1.04274878
68MP0003315_abnormal_perineum_morphology1.01854387
69MP0003186_abnormal_redox_activity1.01583978
70MP0000613_abnormal_salivary_gland1.01525715
71MP0002118_abnormal_lipid_homeostasis1.00116892
72MP0000762_abnormal_tongue_morphology0.99616220
73MP0002060_abnormal_skin_morphology0.99337019
74MP0000537_abnormal_urethra_morphology0.99120605
75MP0004858_abnormal_nervous_system0.98486815
76MP0001944_abnormal_pancreas_morphology0.98281649
77MP0001849_ear_inflammation0.98250449
78MP0003868_abnormal_feces_composition0.97541243
79MP0001664_abnormal_digestion0.96388979
80MP0010678_abnormal_skin_adnexa0.96074687
81MP0001697_abnormal_embryo_size0.94754060
82MP0000579_abnormal_nail_morphology0.94220816
83MP0000350_abnormal_cell_proliferation0.93796978
84MP0001661_extended_life_span0.93434860
85MP0005319_abnormal_enzyme/_coenzyme0.93226623
86MP0003283_abnormal_digestive_organ0.92659664
87MP0003984_embryonic_growth_retardation0.91636667
88MP0000470_abnormal_stomach_morphology0.91472062
89MP0008004_abnormal_stomach_pH0.91430377
90MP0008872_abnormal_physiological_respon0.91127744
91MP0002088_abnormal_embryonic_growth/wei0.90206321
92MP0000477_abnormal_intestine_morphology0.88798831
93MP0004133_heterotaxia0.88631305
94MP0008007_abnormal_cellular_replicative0.86840865
95MP0009672_abnormal_birth_weight0.85576818
96MP0005501_abnormal_skin_physiology0.85538192
97MP0002080_prenatal_lethality0.85465095
98MP0001216_abnormal_epidermal_layer0.83771966
99MP0008058_abnormal_DNA_repair0.82017197
100MP0002086_abnormal_extraembryonic_tissu0.81951757
101MP0009931_abnormal_skin_appearance0.81712898
102MP0003453_abnormal_keratinocyte_physiol0.81038945
103MP0000367_abnormal_coat/_hair0.79532252
104MP0003638_abnormal_response/metabolism_0.79077465
105MP0003879_abnormal_hair_cell0.77682723
106MP0004272_abnormal_basement_membrane0.77334389
107MP0008995_early_reproductive_senescence0.76989406
108MP0000678_abnormal_parathyroid_gland0.76896898
109MP0002085_abnormal_embryonic_tissue0.76429201
110MP0003705_abnormal_hypodermis_morpholog0.76214308
111MP0002136_abnormal_kidney_physiology0.75980747
112MP0002163_abnormal_gland_morphology0.75673714
113MP0000377_abnormal_hair_follicle0.73641449
114MP0002693_abnormal_pancreas_physiology0.73084071
115MP0000383_abnormal_hair_follicle0.72141128
116MP0010307_abnormal_tumor_latency0.72073879
117MP0004947_skin_inflammation0.71265085
118MP0003866_abnormal_defecation0.70597867
119MP0003699_abnormal_female_reproductive0.70353490
120MP0000598_abnormal_liver_morphology0.69418047
121MP0003566_abnormal_cell_adhesion0.69330724
122MP0000538_abnormal_urinary_bladder0.69139014
123MP0005670_abnormal_white_adipose0.68627573
124MP0002084_abnormal_developmental_patter0.68621946
125MP0001765_abnormal_ion_homeostasis0.67741133
126MP0009053_abnormal_anal_canal0.67118819
127MP0000653_abnormal_sex_gland0.67056180
128MP0005379_endocrine/exocrine_gland_phen0.66205170
129MP0000627_abnormal_mammary_gland0.64458799
130MP0005389_reproductive_system_phenotype0.64391302
131MP0002277_abnormal_respiratory_mucosa0.63099188
132MP0000516_abnormal_urinary_system0.62619187
133MP0005367_renal/urinary_system_phenotyp0.62619187
134MP0006036_abnormal_mitochondrial_physio0.62448072
135MP0002089_abnormal_postnatal_growth/wei0.62082088

Predicted human phenotypes

RankGene SetZ-score
1Gout (HP:0001997)5.39382261
2Hyperglycinemia (HP:0002154)5.36973477
3Hyperglycinuria (HP:0003108)5.22085316
4Abnormality of glycine metabolism (HP:0010895)4.22099976
5Abnormality of serine family amino acid metabolism (HP:0010894)4.22099976
6Breast hypoplasia (HP:0003187)3.94259148
7Congenital ichthyosiform erythroderma (HP:0007431)3.89085420
8Abnormality of nail color (HP:0100643)3.84672728
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.62786355
10Ileus (HP:0002595)3.54600994
11Amelogenesis imperfecta (HP:0000705)3.52068510
12Abnormal hair laboratory examination (HP:0003328)3.34283171
13Hyperglycemia (HP:0003074)3.28095577
14Abnormality of proline metabolism (HP:0010907)3.20026865
15Hydroxyprolinuria (HP:0003080)3.20026865
16Plantar hyperkeratosis (HP:0007556)3.18935053
17Palmoplantar hyperkeratosis (HP:0000972)3.14502383
18Abnormality of monocarboxylic acid metabolism (HP:0010996)3.08104675
19Hyperuricemia (HP:0002149)3.06854470
20Increased purine levels (HP:0004368)3.06854470
21Abnormality of serum amino acid levels (HP:0003112)3.04102453
22Rough bone trabeculation (HP:0100670)3.03517438
23Hypoglycemic coma (HP:0001325)3.03252474
24Carpal bone hypoplasia (HP:0001498)3.00077013
25Lip pit (HP:0100267)2.95466648
26Impulsivity (HP:0100710)2.92343456
27Palmar hyperkeratosis (HP:0010765)2.89663690
28Hypobetalipoproteinemia (HP:0003563)2.83276260
29Vascular calcification (HP:0004934)2.79160670
30Abnormality of purine metabolism (HP:0004352)2.79026612
31Death in infancy (HP:0001522)2.78592150
32Septate vagina (HP:0001153)2.77728258
33Abnormal pancreas size (HP:0012094)2.77328530
34Flat acetabular roof (HP:0003180)2.69150402
35Abnormality of renin-angiotensin system (HP:0000847)2.68801447
36Intrahepatic cholestasis (HP:0001406)2.67502117
37Secondary amenorrhea (HP:0000869)2.65655873
38Malnutrition (HP:0004395)2.65539977
39Birth length less than 3rd percentile (HP:0003561)2.63037318
40Lethargy (HP:0001254)2.62805484
41Xanthomatosis (HP:0000991)2.61920395
42Parakeratosis (HP:0001036)2.61164490
43Pili torti (HP:0003777)2.60575213
44Ureteral duplication (HP:0000073)2.60538500
45Hyperactive renin-angiotensin system (HP:0000841)2.58046046
46Pustule (HP:0200039)2.57108970
47Oral leukoplakia (HP:0002745)2.55860807
48Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.55808828
49Hyperammonemia (HP:0001987)2.55036270
50Hypotrichosis (HP:0001006)2.55003074
51Popliteal pterygium (HP:0009756)2.52908954
52Megaloblastic anemia (HP:0001889)2.51822298
53Abnormality of nucleobase metabolism (HP:0010932)2.51398299
54Multiple enchondromatosis (HP:0005701)2.50646113
55Abnormality of small intestinal villus morphology (HP:0011472)2.48151590
56Villous atrophy (HP:0011473)2.48151590
57Alkalosis (HP:0001948)2.46823052
58Ventricular fibrillation (HP:0001663)2.46649905
59Microretrognathia (HP:0000308)2.46407626
60Steatorrhea (HP:0002570)2.44868451
61Male infertility (HP:0003251)2.44352442
62Dicarboxylic aciduria (HP:0003215)2.42470687
63Abnormality of dicarboxylic acid metabolism (HP:0010995)2.42470687
64Taurodontia (HP:0000679)2.39836210
65Abnormality of permanent molar morphology (HP:0011071)2.39836210
66Abnormality of the dental root (HP:0006486)2.39836210
67Glycosuria (HP:0003076)2.39758793
68Abnormality of urine glucose concentration (HP:0011016)2.39758793
69Abnormality of sulfur amino acid metabolism (HP:0004339)2.37052849
70Abnormality of magnesium homeostasis (HP:0004921)2.36313118
71Curly hair (HP:0002212)2.35411650
72Woolly hair (HP:0002224)2.34595352
73Decreased circulating renin level (HP:0003351)2.34419232
74Abnormality of fatty-acid metabolism (HP:0004359)2.34018573
75Cerebral hypomyelination (HP:0006808)2.33819151
76Abnormal trabecular bone morphology (HP:0100671)2.30886530
77Abnormal biliary tract morphology (HP:0012440)2.30664198
78Late onset (HP:0003584)2.29899003
79Dehydration (HP:0001944)2.28869574
80Proximal tubulopathy (HP:0000114)2.28520180
81Fat malabsorption (HP:0002630)2.27376461
82Abnormality of chloride homeostasis (HP:0011422)2.26659162
83Abnormality of vitamin metabolism (HP:0100508)2.26570877
84Progressive muscle weakness (HP:0003323)2.24685051
85Premature ovarian failure (HP:0008209)2.24447077
86Hypolipoproteinemia (HP:0010981)2.23056350
87Insulin-resistant diabetes mellitus (HP:0000831)2.20666581
88Onycholysis (HP:0001806)2.19138413
89Trismus (HP:0000211)2.18667006
90Right ventricular cardiomyopathy (HP:0011663)2.18155274
91Abnormality of the distal phalanges of the toes (HP:0010182)2.16628308
92Abnormality of the dental pulp (HP:0006479)2.15832214
93Prolonged partial thromboplastin time (HP:0003645)2.14932468
94Cardiovascular calcification (HP:0011915)2.14738292
95Abnormality of glutamine family amino acid metabolism (HP:0010902)2.13716529
96Sparse eyelashes (HP:0000653)2.11417516
97Abnormality of molar (HP:0011077)2.10726942
98Abnormality of molar morphology (HP:0011070)2.10726942
99Hyperphosphatemia (HP:0002905)2.08292489
100Aplasia/Hypoplasia of the patella (HP:0006498)2.07742993
101Polycythemia (HP:0001901)2.07664685
102Renal salt wasting (HP:0000127)2.06446755
103Concave nail (HP:0001598)2.06330069
104Prolonged neonatal jaundice (HP:0006579)2.05651957
105Macrocytic anemia (HP:0001972)2.05363257
106Erythema (HP:0010783)2.03973851
107Irritability (HP:0000737)2.03268924
108Insulin resistance (HP:0000855)2.02153976
109Generalized aminoaciduria (HP:0002909)2.00841582
110Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.00269569
111Hyponatremia (HP:0002902)1.99838917
112Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.98777474
113Deep venous thrombosis (HP:0002625)1.98293423
114Hypokinesia (HP:0002375)1.97424703
115Corneal erosion (HP:0200020)1.96608382
116Conjugated hyperbilirubinemia (HP:0002908)1.96485156
117Abnormality of pyrimidine metabolism (HP:0004353)1.96141672
118Patellar aplasia (HP:0006443)1.95069220
119Abnormal cartilage morphology (HP:0002763)1.94757217
120Hyperaldosteronism (HP:0000859)1.94494825
121Shawl scrotum (HP:0000049)1.94246153
122Pterygium (HP:0001059)1.94067951
123Chronic bronchitis (HP:0004469)1.94052845
124Fragile nails (HP:0001808)1.93937200
125Abnormality of the intrinsic pathway (HP:0010989)1.93445196
126Abnormality of the umbilical cord (HP:0010881)1.91780883
127Hyperinsulinemic hypoglycemia (HP:0000825)1.91769365
128Nausea (HP:0002018)1.91748141
129Distal lower limb muscle weakness (HP:0009053)1.91499486
130Alopecia of scalp (HP:0002293)1.90766707
131Bundle branch block (HP:0011710)1.90480716
132Nail dystrophy (HP:0008404)1.90115138
133Abnormality of aspartate family amino acid metabolism (HP:0010899)1.89451553
134Hypoglycemic seizures (HP:0002173)1.88756274
135Aplasia/hypoplasia of the uterus (HP:0008684)1.88527573
136Hyperlipoproteinemia (HP:0010980)1.88439428
137Abnormality of vitamin B metabolism (HP:0004340)1.88121886
138Thick nail (HP:0001805)1.87083787
139Hypomagnesemia (HP:0002917)1.86487803
140Abnormality of the gastric mucosa (HP:0004295)1.85496817
141Abnormality of the proximal phalanges of the hand (HP:0009834)1.85480155
142Brushfield spots (HP:0001088)1.85184272
143Hypoplasia of the uterus (HP:0000013)1.84204019
144Hypoalphalipoproteinemia (HP:0003233)1.83592617
145Glomerulosclerosis (HP:0000096)1.83201702
146Abnormalities of placenta or umbilical cord (HP:0001194)1.80423530
147Renal tubular acidosis (HP:0001947)1.80325444
148Atrioventricular block (HP:0001678)1.79711745
149Ketosis (HP:0001946)1.79403581
150Hyperphosphaturia (HP:0003109)1.78904812
151Abnormality of the vitamin B12 metabolism (HP:0004341)1.78750534
152Widely patent fontanelles and sutures (HP:0004492)1.78282472
153CNS demyelination (HP:0007305)1.77629950
154Absent eyebrow (HP:0002223)1.76964704
155Abnormal tarsal ossification (HP:0008369)1.76615846
156Degeneration of anterior horn cells (HP:0002398)1.75956936
157Abnormality of the anterior horn cell (HP:0006802)1.75956936
158Abdominal distention (HP:0003270)1.74785289
159Symptomatic seizures (HP:0011145)1.74126798

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.85401907
2EPHA24.59689526
3WEE12.90588032
4STK38L2.83888501
5MAP3K122.79904293
6NEK22.65109633
7LATS12.60090873
8FRK2.52294353
9STK392.48797777
10PLK42.47022044
11EIF2AK12.36111672
12TTK2.34363077
13BRSK22.32493570
14AKT32.30895206
15BCKDK2.19359693
16PBK2.16418276
17MAP2K22.13906960
18SMG12.07935565
19NME22.06542537
20NME12.06504517
21VRK21.96550241
22BRAF1.88016748
23MAP3K31.70208219
24FER1.65465209
25STK161.62158281
26DYRK31.61651770
27MST1R1.59862386
28LATS21.58197920
29PLK11.56659625
30MUSK1.55318443
31OXSR11.53739399
32ACVR1B1.47607398
33PRKCI1.44142308
34AURKB1.41959286
35ARAF1.39311757
36IRAK31.38848045
37SIK11.38156962
38TESK11.37150364
39RPS6KA41.33036080
40NEK11.32447208
41STK31.28727332
42WNK31.28075457
43TAOK31.26780067
44BRSK11.20880957
45TAOK11.15598492
46PLK31.11836368
47AURKA1.10096066
48MAP3K81.07463227
49CHEK21.06807481
50EIF2AK31.06797444
51MAPK151.05790889
52NUAK11.02308569
53RPS6KB21.01847065
54SRPK10.98625890
55PKN20.96866167
56TSSK60.94761359
57GRK10.93502731
58PRKG20.90331846
59PASK0.87680035
60MET0.86429951
61STK100.85350981
62SCYL20.84745320
63TESK20.84664981
64ILK0.83881553
65RIPK10.81344434
66MAP2K60.80665205
67ERBB40.80420490
68PAK40.78766501
69PIK3CA0.78294554
70DYRK20.76675895
71MELK0.75351574
72MAP3K110.75166513
73ZAK0.75134538
74CDK70.74361987
75DAPK10.74329285
76PIM20.70651644
77MST40.69551698
78NEK60.68807920
79CDK40.67853148
80KSR20.66353762
81PTK20.65194382
82MAP3K20.65131750
83FGFR40.65047330
84TRIB30.63800537
85ABL20.63252766
86INSRR0.62884330
87TRIM280.60959038
88MAPK110.59430084
89TAF10.56418824
90LMTK20.56025985
91WNK40.55791451
92IRAK10.55762421
93STK240.54796312
94EEF2K0.54550315
95PDK40.53903377
96PDK30.53903377
97PAK10.52796838
98CHUK0.52238002
99PRKAA10.51925652
100CAMK2D0.51492720
101STK380.51422808
102MYLK0.50939569
103FGFR10.50786791
104ERN10.50182490
105MAP2K10.50019480
106CAMK2G0.49877331
107LRRK20.48336527
108MAP3K10.47988505
109MAPKAPK30.47358507
110BMX0.47339398
111CSNK1G10.46996143
112MAP2K30.45865496
113NLK0.45655865
114EPHB10.45127290
115MAP3K90.44867855
116IRAK20.44023953
117CHEK10.43088710
118PTK60.42282814
119MKNK20.42151635
120PRKD30.41890335
121CDC70.40746141
122CCNB10.40089545
123CSNK2A10.37310030
124MTOR0.36379399
125CSNK1E0.36332455
126VRK10.35650560
127IKBKB0.35621876
128RAF10.35318403
129PDK20.35127706
130MAP3K50.34885188
131MARK30.34094456
132AKT20.32973091
133PIM10.32611688
134PDPK10.31600145
135PINK10.31441297
136CSNK2A20.30982706
137DYRK1B0.30929875
138PRKAA20.26806589
139CSNK1A10.26169037
140PRKCE0.25886408
141TBK10.25191138
142MAPKAPK20.24996324
143EIF2AK20.24920811

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.43872486
2Maturity onset diabetes of the young_Homo sapiens_hsa049503.02780880
3RNA polymerase_Homo sapiens_hsa030203.00727555
4Folate biosynthesis_Homo sapiens_hsa007902.97484073
5Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.41039289
6Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.28752710
7Sulfur metabolism_Homo sapiens_hsa009202.27865551
8Sulfur relay system_Homo sapiens_hsa041222.25569152
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.23516742
10Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.07659837
11Fat digestion and absorption_Homo sapiens_hsa049752.03354794
12Vitamin digestion and absorption_Homo sapiens_hsa049771.99567736
13Drug metabolism - other enzymes_Homo sapiens_hsa009831.83797892
14Selenocompound metabolism_Homo sapiens_hsa004501.79781506
15Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.78768668
16RNA transport_Homo sapiens_hsa030131.75800166
17Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.74311272
18Pyrimidine metabolism_Homo sapiens_hsa002401.72937068
19Proteasome_Homo sapiens_hsa030501.72295492
20Sphingolipid metabolism_Homo sapiens_hsa006001.67478215
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.67108305
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65458726
23Cysteine and methionine metabolism_Homo sapiens_hsa002701.56423771
24Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.55955316
25Cyanoamino acid metabolism_Homo sapiens_hsa004601.50474295
26Regulation of autophagy_Homo sapiens_hsa041401.50353340
27Primary bile acid biosynthesis_Homo sapiens_hsa001201.50035238
28Fatty acid elongation_Homo sapiens_hsa000621.49786473
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46807043
30Ribosome_Homo sapiens_hsa030101.45753718
31Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.40767966
32Butanoate metabolism_Homo sapiens_hsa006501.40622610
33Glutathione metabolism_Homo sapiens_hsa004801.38808055
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.36051767
35Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.34959608
36Histidine metabolism_Homo sapiens_hsa003401.32435922
37Cell cycle_Homo sapiens_hsa041101.32407366
38Linoleic acid metabolism_Homo sapiens_hsa005911.30257027
39Tryptophan metabolism_Homo sapiens_hsa003801.30143410
40Pentose phosphate pathway_Homo sapiens_hsa000301.27826613
41Fatty acid degradation_Homo sapiens_hsa000711.24250710
42Vibrio cholerae infection_Homo sapiens_hsa051101.22892198
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.21880940
44Glycerophospholipid metabolism_Homo sapiens_hsa005641.20868976
45Arginine and proline metabolism_Homo sapiens_hsa003301.19611391
46beta-Alanine metabolism_Homo sapiens_hsa004101.14522596
47Protein export_Homo sapiens_hsa030601.14328919
48Fructose and mannose metabolism_Homo sapiens_hsa000511.13746712
49Arginine biosynthesis_Homo sapiens_hsa002201.12694957
50Chemical carcinogenesis_Homo sapiens_hsa052041.10678344
51Basal transcription factors_Homo sapiens_hsa030221.09688751
52Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.09298869
53Biosynthesis of amino acids_Homo sapiens_hsa012301.09040909
54Peroxisome_Homo sapiens_hsa041461.07808390
55Retinol metabolism_Homo sapiens_hsa008301.04181159
56Mineral absorption_Homo sapiens_hsa049780.97054232
57One carbon pool by folate_Homo sapiens_hsa006700.96907419
58p53 signaling pathway_Homo sapiens_hsa041150.95426613
59* Tight junction_Homo sapiens_hsa045300.93617755
60Purine metabolism_Homo sapiens_hsa002300.92984678
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.91393049
62Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.90581633
63Spliceosome_Homo sapiens_hsa030400.88150759
64Carbon metabolism_Homo sapiens_hsa012000.87798315
652-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.86647885
66Steroid biosynthesis_Homo sapiens_hsa001000.82821688
67Nitrogen metabolism_Homo sapiens_hsa009100.81016486
68Collecting duct acid secretion_Homo sapiens_hsa049660.80454047
69Galactose metabolism_Homo sapiens_hsa000520.80409168
70Glycerolipid metabolism_Homo sapiens_hsa005610.78831747
71Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.78406707
72Caffeine metabolism_Homo sapiens_hsa002320.77801971
73Homologous recombination_Homo sapiens_hsa034400.77226416
74DNA replication_Homo sapiens_hsa030300.76696358
75Phenylalanine metabolism_Homo sapiens_hsa003600.76308887
76Steroid hormone biosynthesis_Homo sapiens_hsa001400.76150411
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75097642
78Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.73999884
79Metabolic pathways_Homo sapiens_hsa011000.72834546
80Arachidonic acid metabolism_Homo sapiens_hsa005900.72164607
81Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.71654772
82N-Glycan biosynthesis_Homo sapiens_hsa005100.71285479
83Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.71063639
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.70958336
85Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.70132194
86Nucleotide excision repair_Homo sapiens_hsa034200.70046342
87Oxidative phosphorylation_Homo sapiens_hsa001900.68938370
88Propanoate metabolism_Homo sapiens_hsa006400.68269172
89Base excision repair_Homo sapiens_hsa034100.68147763
90Mismatch repair_Homo sapiens_hsa034300.68010275
91RNA degradation_Homo sapiens_hsa030180.63327733
92PPAR signaling pathway_Homo sapiens_hsa033200.62989858
93Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.62545309
94Bile secretion_Homo sapiens_hsa049760.61656212
95Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.59211535
96Renin-angiotensin system_Homo sapiens_hsa046140.59177145
97Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.57275912
98ABC transporters_Homo sapiens_hsa020100.56675211
99Circadian rhythm_Homo sapiens_hsa047100.56341003
100Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.54653659
101Starch and sucrose metabolism_Homo sapiens_hsa005000.54310262
102Pyruvate metabolism_Homo sapiens_hsa006200.51719100
103Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.51561070
104Fatty acid metabolism_Homo sapiens_hsa012120.49862150
105Tyrosine metabolism_Homo sapiens_hsa003500.49264197
106Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.47614799
107Other glycan degradation_Homo sapiens_hsa005110.46714414
108Thyroid cancer_Homo sapiens_hsa052160.46631236
109Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.44092374
110Protein digestion and absorption_Homo sapiens_hsa049740.43747914
111Fanconi anemia pathway_Homo sapiens_hsa034600.43116905
112Complement and coagulation cascades_Homo sapiens_hsa046100.43107058
113Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42022245
114Thyroid hormone synthesis_Homo sapiens_hsa049180.41293109
115Hepatitis C_Homo sapiens_hsa051600.41034270
116Bladder cancer_Homo sapiens_hsa052190.40951629
117Huntingtons disease_Homo sapiens_hsa050160.37123690
118Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.36778730
119Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.36253502
120Ether lipid metabolism_Homo sapiens_hsa005650.33654354
121Fatty acid biosynthesis_Homo sapiens_hsa000610.33515579
122mRNA surveillance pathway_Homo sapiens_hsa030150.32026124
123Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31834886
124Pancreatic secretion_Homo sapiens_hsa049720.31811638

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