CRBN

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic mental retardation. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.07362390
2synaptic vesicle exocytosis (GO:0016079)4.43541895
3glutamate secretion (GO:0014047)4.01480978
4regulation of synaptic vesicle exocytosis (GO:2000300)4.01019588
5negative regulation of synaptic transmission, GABAergic (GO:0032229)3.96618905
6DNA deamination (GO:0045006)3.95104721
7regulation of short-term neuronal synaptic plasticity (GO:0048172)3.85869896
8neuron cell-cell adhesion (GO:0007158)3.83397813
9transferrin transport (GO:0033572)3.82091375
10regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.72949736
11synaptic vesicle maturation (GO:0016188)3.70077480
12regulation of synaptic vesicle transport (GO:1902803)3.69563758
13positive regulation of gamma-delta T cell activation (GO:0046645)3.67305998
14platelet dense granule organization (GO:0060155)3.66090104
15negative regulation of dendrite morphogenesis (GO:0050774)3.65704300
16neuronal action potential propagation (GO:0019227)3.65134977
17ATP hydrolysis coupled proton transport (GO:0015991)3.59111481
18energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.59111481
19ferric iron transport (GO:0015682)3.56589974
20trivalent inorganic cation transport (GO:0072512)3.56589974
21succinate metabolic process (GO:0006105)3.51835087
22negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.47306508
23negative regulation of cell killing (GO:0031342)3.47306508
24neural tube formation (GO:0001841)3.45827164
25synaptic vesicle docking involved in exocytosis (GO:0016081)3.45751258
26protein localization to cilium (GO:0061512)3.45239864
27negative regulation of dendrite development (GO:2000171)3.44881474
28adenosine metabolic process (GO:0046085)3.41600766
29regulation of isotype switching to IgG isotypes (GO:0048302)3.41293405
30DNA double-strand break processing (GO:0000729)3.36996995
31neurotransmitter secretion (GO:0007269)3.35647527
32respiratory chain complex IV assembly (GO:0008535)3.34940884
33prenylation (GO:0097354)3.31682597
34protein prenylation (GO:0018342)3.31682597
35vocalization behavior (GO:0071625)3.25385509
36neuron-neuron synaptic transmission (GO:0007270)3.24869056
37gamma-aminobutyric acid signaling pathway (GO:0007214)3.24276388
38regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.23327198
39regulation of mitotic spindle checkpoint (GO:1903504)3.23327198
40piRNA metabolic process (GO:0034587)3.19303280
41cellular response to interleukin-15 (GO:0071350)3.18400911
42regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.18226825
43long-term synaptic potentiation (GO:0060291)3.18198820
44oxaloacetate metabolic process (GO:0006107)3.13899107
45positive regulation of mitochondrial fission (GO:0090141)3.10271951
46NADH metabolic process (GO:0006734)3.10034877
47protein localization to synapse (GO:0035418)3.06869199
48presynaptic membrane assembly (GO:0097105)3.05762819
49synaptic transmission, glutamatergic (GO:0035249)3.05093906
50membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.04229151
51proteasome assembly (GO:0043248)3.01771503
52histone mRNA catabolic process (GO:0071044)3.01743784
53cytochrome complex assembly (GO:0017004)2.98838589
54detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.98103768
55phagosome maturation (GO:0090382)2.96419686
56RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.95551906
57neurotransmitter-gated ion channel clustering (GO:0072578)2.95520552
58mitochondrial respiratory chain complex assembly (GO:0033108)2.95023301
59mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.94714709
60mitochondrial respiratory chain complex I assembly (GO:0032981)2.94714709
61NADH dehydrogenase complex assembly (GO:0010257)2.94714709
62regulation of glutamate receptor signaling pathway (GO:1900449)2.93357576
63neurofilament cytoskeleton organization (GO:0060052)2.88024188
64cullin deneddylation (GO:0010388)2.83028393
65regulation of regulatory T cell differentiation (GO:0045589)2.82047786
66positive regulation of granulocyte differentiation (GO:0030854)2.81758159
67regulation of cilium movement (GO:0003352)2.81409965
68presynaptic membrane organization (GO:0097090)2.81284449
69protein targeting to Golgi (GO:0000042)2.81269050
70serotonin receptor signaling pathway (GO:0007210)2.81203843
71nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.80159519
72anterograde synaptic vesicle transport (GO:0048490)2.79772401
73tricarboxylic acid cycle (GO:0006099)2.79635199
74startle response (GO:0001964)2.79482052
75neurotransmitter transport (GO:0006836)2.78187110
76inositol phosphate catabolic process (GO:0071545)2.76628296
77positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.76557431
78ionotropic glutamate receptor signaling pathway (GO:0035235)2.76344324
79membrane depolarization during action potential (GO:0086010)2.74875045
80epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.74497258
81response to pheromone (GO:0019236)2.73577694
82positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.73325459
83exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.72929184
84negative regulation of appetite (GO:0032099)2.72294602
85negative regulation of response to food (GO:0032096)2.72294602
86regulation of synaptic transmission, glutamatergic (GO:0051966)2.71792626
87negative regulation of heart rate (GO:0010459)2.71685868
88mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.71190120
89calcium ion-dependent exocytosis (GO:0017156)2.70696752
90regulation of acyl-CoA biosynthetic process (GO:0050812)2.70266451
91response to interleukin-15 (GO:0070672)2.69231032
92regulation of hexokinase activity (GO:1903299)2.68906782
93regulation of glucokinase activity (GO:0033131)2.68906782
94establishment of protein localization to Golgi (GO:0072600)2.68017261
95L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.67608021
96regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.67565519
97regulation of neurotransmitter secretion (GO:0046928)2.66440684
98regulation of meiosis I (GO:0060631)2.65953953
99negative T cell selection (GO:0043383)2.65603050
100histone H2A acetylation (GO:0043968)2.65570098
101protein complex biogenesis (GO:0070271)2.63903096
102negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.63830001
103regulation of neurotransmitter levels (GO:0001505)2.63788738
104cerebellar granule cell differentiation (GO:0021707)2.63570500
105detection of light stimulus involved in visual perception (GO:0050908)2.63309062
106detection of light stimulus involved in sensory perception (GO:0050962)2.63309062
107positive regulation of humoral immune response (GO:0002922)2.63158263
108reciprocal DNA recombination (GO:0035825)2.62966727
109reciprocal meiotic recombination (GO:0007131)2.62966727
110synaptic vesicle endocytosis (GO:0048488)2.62966243
111regulation of voltage-gated calcium channel activity (GO:1901385)2.62742552
112protein-cofactor linkage (GO:0018065)2.60713598
113positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.60308311
114mechanosensory behavior (GO:0007638)2.59621747
115positive regulation of natural killer cell mediated immunity (GO:0002717)2.59195506
116positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)2.59195506
117regulation of excitatory postsynaptic membrane potential (GO:0060079)2.59061489
118mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.58929879
119negative regulation of thymocyte apoptotic process (GO:0070244)2.58760703
120regulation of protein kinase A signaling (GO:0010738)2.57692920
121positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.57156246
122vesicle transport along microtubule (GO:0047496)2.57016277
123cerebellar Purkinje cell differentiation (GO:0021702)2.56582145
124protein K11-linked deubiquitination (GO:0035871)2.56412636
125negative regulation of DNA recombination (GO:0045910)2.55861737
126mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.55829600
127male meiosis (GO:0007140)2.55575810
128negative regulation of DNA-dependent DNA replication (GO:2000104)2.55447763
129regulation of cell communication by electrical coupling (GO:0010649)2.54302292
130establishment of synaptic vesicle localization (GO:0097480)2.54293255
131synaptic vesicle transport (GO:0048489)2.54293255
132dopamine transport (GO:0015872)2.53657135
133activation of protein kinase A activity (GO:0034199)2.53598534
134establishment of vesicle localization (GO:0051650)2.53537878
135regulation of neurotransmitter transport (GO:0051588)2.53417237
136chaperone-mediated protein transport (GO:0072321)2.52849036
137somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.52848043
138somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.52848043
139isotype switching (GO:0045190)2.52848043
140neurotransmitter uptake (GO:0001504)2.52440422
141positive regulation of membrane potential (GO:0045838)2.52332302
142S-adenosylmethionine metabolic process (GO:0046500)2.52082918
143regulation of B cell receptor signaling pathway (GO:0050855)2.52029856
144regulation of gamma-delta T cell differentiation (GO:0045586)2.51516807
145axoneme assembly (GO:0035082)2.51359323
146striatum development (GO:0021756)2.51052579
147glutamate receptor signaling pathway (GO:0007215)2.50973130
148protein deneddylation (GO:0000338)2.50948403
149synapsis (GO:0007129)2.50471075
150response to histamine (GO:0034776)2.49836799
151gamma-aminobutyric acid transport (GO:0015812)2.49759367
152positive regulation of cellular amide metabolic process (GO:0034250)2.49574475
153phosphorylated carbohydrate dephosphorylation (GO:0046838)2.49172125
154inositol phosphate dephosphorylation (GO:0046855)2.49172125
155polyol catabolic process (GO:0046174)2.47817232
156positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.46226768
157catecholamine transport (GO:0051937)2.45666510
158regulation of postsynaptic membrane potential (GO:0060078)2.45601390
159negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.45065184
160synaptic transmission (GO:0007268)2.44996961
161retinal cone cell development (GO:0046549)2.43974820
162mast cell degranulation (GO:0043303)2.43884648
163mast cell activation involved in immune response (GO:0002279)2.43884648
164mannosylation (GO:0097502)2.42733319
165branched-chain amino acid catabolic process (GO:0009083)2.41408770
166regulation of protein glycosylation (GO:0060049)2.40416380
167preassembly of GPI anchor in ER membrane (GO:0016254)2.39958166
168sequestering of actin monomers (GO:0042989)2.39554065
169purine-containing compound salvage (GO:0043101)2.38789606
170pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.38462218
171negative regulation of telomere maintenance (GO:0032205)2.37432318
172adaptation of signaling pathway (GO:0023058)2.36866371
173amino acid salvage (GO:0043102)2.36069430
174L-methionine salvage (GO:0071267)2.36069430
175L-methionine biosynthetic process (GO:0071265)2.36069430
176fucose catabolic process (GO:0019317)2.36014842
177L-fucose metabolic process (GO:0042354)2.36014842
178L-fucose catabolic process (GO:0042355)2.36014842
179DNA methylation involved in gamete generation (GO:0043046)2.35709842
180indolalkylamine metabolic process (GO:0006586)2.35601488
181centriole replication (GO:0007099)2.35253493
182water-soluble vitamin biosynthetic process (GO:0042364)2.35057904
183regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.34738639
184regulation of memory T cell differentiation (GO:0043380)2.32421479
185double-strand break repair via homologous recombination (GO:0000724)2.31671955
186recombinational repair (GO:0000725)2.30379161
187replication fork processing (GO:0031297)2.29618267
188histone mRNA metabolic process (GO:0008334)2.29473369
189GPI anchor metabolic process (GO:0006505)2.27384800
190cytidine deamination (GO:0009972)2.26590112
191cytidine metabolic process (GO:0046087)2.26590112
192cytidine catabolic process (GO:0006216)2.26590112
193regulation of Golgi to plasma membrane protein transport (GO:0042996)2.24833404
194base-excision repair, AP site formation (GO:0006285)2.24736950
195relaxation of smooth muscle (GO:0044557)2.24730297

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.33180450
2TAF15_26573619_Chip-Seq_HEK293_Human3.62385953
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.33188435
4TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.15176198
5EZH2_22144423_ChIP-Seq_EOC_Human3.11229191
6ZNF274_21170338_ChIP-Seq_K562_Hela2.66256885
7ZFP57_27257070_Chip-Seq_ESCs_Mouse2.64919186
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.61254688
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.53171078
10POU3F2_20337985_ChIP-ChIP_501MEL_Human2.48325957
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.44526340
12GABP_17652178_ChIP-ChIP_JURKAT_Human2.25229509
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.22768895
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.15839349
15P300_19829295_ChIP-Seq_ESCs_Human2.08024662
16SMAD4_21799915_ChIP-Seq_A2780_Human2.05180650
17REST_21632747_ChIP-Seq_MESCs_Mouse2.05037333
18SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.01822520
19SMAD_19615063_ChIP-ChIP_OVARY_Human2.01623096
20CTBP2_25329375_ChIP-Seq_LNCAP_Human2.00287547
21FLI1_27457419_Chip-Seq_LIVER_Mouse1.98092034
22CTBP1_25329375_ChIP-Seq_LNCAP_Human1.98066760
23HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.95508523
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.93343397
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.90666744
26BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.90559022
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89936532
28ELK1_19687146_ChIP-ChIP_HELA_Human1.85762209
29* VDR_23849224_ChIP-Seq_CD4+_Human1.82802543
30GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.81855962
31REST_18959480_ChIP-ChIP_MESCs_Mouse1.79947438
32IGF1R_20145208_ChIP-Seq_DFB_Human1.75484701
33OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72855017
34SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.70062984
35EZH2_27294783_Chip-Seq_NPCs_Mouse1.67424405
36FUS_26573619_Chip-Seq_HEK293_Human1.67058725
37SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.63821919
38PCGF2_27294783_Chip-Seq_ESCs_Mouse1.62942644
39* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.59374140
40AR_25329375_ChIP-Seq_VCAP_Human1.58282055
41JARID2_20064375_ChIP-Seq_MESCs_Mouse1.58106373
42ELF1_17652178_ChIP-ChIP_JURKAT_Human1.56903159
43CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.52922868
44SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.50508615
45PIAS1_25552417_ChIP-Seq_VCAP_Human1.47398342
46* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.46708614
47SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.46291287
48UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.45397147
49* ER_23166858_ChIP-Seq_MCF-7_Human1.44794348
50VDR_22108803_ChIP-Seq_LS180_Human1.43416742
51STAT3_23295773_ChIP-Seq_U87_Human1.43369586
52NR3C1_23031785_ChIP-Seq_PC12_Mouse1.43309965
53* PRDM14_20953172_ChIP-Seq_ESCs_Human1.42349988
54TCF4_23295773_ChIP-Seq_U87_Human1.41193862
55JUN_21703547_ChIP-Seq_K562_Human1.41121731
56SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.40983416
57SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.39637135
58NANOG_18555785_Chip-Seq_ESCs_Mouse1.38713265
59IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.38086666
60TP53_22573176_ChIP-Seq_HFKS_Human1.37855313
61PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.37272727
62FOXP3_21729870_ChIP-Seq_TREG_Human1.36619835
63NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.36457340
64* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.35024068
65MYC_18940864_ChIP-ChIP_HL60_Human1.34397493
66SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.33114293
67BMI1_23680149_ChIP-Seq_NPCS_Mouse1.32735393
68* EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32369291
69PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.31955828
70CRX_20693478_ChIP-Seq_RETINA_Mouse1.30546477
71FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.29852657
72MTF2_20144788_ChIP-Seq_MESCs_Mouse1.29553238
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.28779027
74CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.28149438
75TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.27850987
76RUNX_20019798_ChIP-Seq_JUKART_Human1.27606675
77PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.25883495
78* EWS_26573619_Chip-Seq_HEK293_Human1.25098348
79IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.24925946
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.24802579
81RNF2_27304074_Chip-Seq_NSC_Mouse1.23839273
82KDM2B_26808549_Chip-Seq_REH_Human1.23069775
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.22633474
84AR_21572438_ChIP-Seq_LNCaP_Human1.22024723
85E2F1_18555785_Chip-Seq_ESCs_Mouse1.21690765
86SOX2_21211035_ChIP-Seq_LN229_Gbm1.21344006
87RARB_27405468_Chip-Seq_BRAIN_Mouse1.20844453
88SALL4_22934838_ChIP-ChIP_CD34+_Human1.20649750
89EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20192617
90STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19418823
91IRF8_22096565_ChIP-ChIP_GC-B_Human1.18668969
92* SRF_21415370_ChIP-Seq_HL-1_Mouse1.17712427
93FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.17609252
94MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.16626033
95MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.16393448
96EED_16625203_ChIP-ChIP_MESCs_Mouse1.16092642
97FOXA1_21572438_ChIP-Seq_LNCaP_Human1.15343982
98NOTCH1_21737748_ChIP-Seq_TLL_Human1.15088580
99P53_22387025_ChIP-Seq_ESCs_Mouse1.14726690
100LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.14395356
101CMYC_18555785_Chip-Seq_ESCs_Mouse1.14049539
102SUZ12_27294783_Chip-Seq_NPCs_Mouse1.13123820
103RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.12795925
104GATA3_26560356_Chip-Seq_TH2_Human1.12765408
105SUZ12_18555785_Chip-Seq_ESCs_Mouse1.12573193
106STAT3_18555785_Chip-Seq_ESCs_Mouse1.12253053
107JARID2_20075857_ChIP-Seq_MESCs_Mouse1.12208126
108FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.11348918
109OCT4_21477851_ChIP-Seq_ESCs_Mouse1.10919806
110HOXB4_20404135_ChIP-ChIP_EML_Mouse1.10512068
111TCF4_22108803_ChIP-Seq_LS180_Human1.10404831
112EZH2_18974828_ChIP-Seq_MESCs_Mouse1.09389218
113RNF2_18974828_ChIP-Seq_MESCs_Mouse1.09389218
114SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.09026692
115TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08656878
116IRF1_19129219_ChIP-ChIP_H3396_Human1.08343495
117E2F4_17652178_ChIP-ChIP_JURKAT_Human1.08209964
118P300_18555785_Chip-Seq_ESCs_Mouse1.06539319
119BCAT_22108803_ChIP-Seq_LS180_Human1.06293901
120FOXA1_25329375_ChIP-Seq_VCAP_Human1.05938818
121FOXA1_27270436_Chip-Seq_PROSTATE_Human1.05938818
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05910027
123MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.05694204
124EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05449713
125* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.04856330
126RUNX2_22187159_ChIP-Seq_PCA_Human1.04704310
127CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.04563021
128RUNX1_27457419_Chip-Seq_LIVER_Mouse1.04547962
129NANOG_19829295_ChIP-Seq_ESCs_Human1.03569152
130SOX2_19829295_ChIP-Seq_ESCs_Human1.03569152
131EZH2_27304074_Chip-Seq_ESCs_Mouse1.03085061
132SOX2_18555785_Chip-Seq_ESCs_Mouse1.02753291
133DROSHA_22980978_ChIP-Seq_HELA_Human1.02148163
134* HTT_18923047_ChIP-ChIP_STHdh_Human1.01758889
135FLI1_21867929_ChIP-Seq_TH2_Mouse1.01536996
136KLF5_20875108_ChIP-Seq_MESCs_Mouse1.01450110
137VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.01310797
138CBP_20019798_ChIP-Seq_JUKART_Human1.01085938
139IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.01085938
140CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01027346
141NFE2_27457419_Chip-Seq_LIVER_Mouse1.00465863
142* EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.98056073

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.27862229
2MP0004859_abnormal_synaptic_plasticity3.87205065
3MP0002736_abnormal_nociception_after3.37583221
4MP0001968_abnormal_touch/_nociception3.35410933
5MP0002735_abnormal_chemical_nociception3.26548935
6MP0004270_analgesia3.09011066
7MP0003635_abnormal_synaptic_transmissio2.89103416
8MP0002102_abnormal_ear_morphology2.88337412
9MP0009745_abnormal_behavioral_response2.78251788
10MP0009046_muscle_twitch2.74118392
11MP0000569_abnormal_digit_pigmentation2.68454805
12MP0002064_seizures2.57992603
13MP0006276_abnormal_autonomic_nervous2.43077605
14MP0002063_abnormal_learning/memory/cond2.41021851
15MP0002734_abnormal_mechanical_nocicepti2.40771172
16MP0002272_abnormal_nervous_system2.40094843
17MP0002822_catalepsy2.39678278
18MP0001986_abnormal_taste_sensitivity2.38490869
19MP0002876_abnormal_thyroid_physiology2.31182054
20MP0005075_abnormal_melanosome_morpholog2.29072227
21MP0005464_abnormal_platelet_physiology2.25329647
22MP0001501_abnormal_sleep_pattern2.25207016
23MP0002572_abnormal_emotion/affect_behav2.24978768
24MP0001529_abnormal_vocalization2.12425743
25MP0001440_abnormal_grooming_behavior2.10220961
26MP0003329_amyloid_beta_deposits2.00085920
27MP0002067_abnormal_sensory_capabilities1.93999518
28MP0002733_abnormal_thermal_nociception1.92993501
29MP0001905_abnormal_dopamine_level1.92164425
30MP0005671_abnormal_response_to1.90317292
31MP0005084_abnormal_gallbladder_morpholo1.90296758
32MP0001970_abnormal_pain_threshold1.87711437
33MP0001486_abnormal_startle_reflex1.84259874
34MP0005646_abnormal_pituitary_gland1.79596286
35MP0008058_abnormal_DNA_repair1.76873105
36MP0009697_abnormal_copulation1.72783119
37MP0005386_behavior/neurological_phenoty1.71683809
38MP0004924_abnormal_behavior1.71683809
39MP0006072_abnormal_retinal_apoptosis1.64170892
40MP0003787_abnormal_imprinting1.59300961
41MP0004215_abnormal_myocardial_fiber1.58684586
42MP0005253_abnormal_eye_physiology1.58043676
43MP0008995_early_reproductive_senescence1.53754055
44MP0001984_abnormal_olfaction1.49085311
45MP0006292_abnormal_olfactory_placode1.48549167
46MP0000604_amyloidosis1.47684930
47MP0005410_abnormal_fertilization1.45775247
48MP0008569_lethality_at_weaning1.42858662
49MP0010386_abnormal_urinary_bladder1.42304513
50MP0002837_dystrophic_cardiac_calcinosis1.39511481
51MP0003183_abnormal_peptide_metabolism1.37835418
52MP0003011_delayed_dark_adaptation1.37265914
53MP0004084_abnormal_cardiac_muscle1.36281850
54MP0001485_abnormal_pinna_reflex1.35573481
55MP0003718_maternal_effect1.33353650
56MP0003633_abnormal_nervous_system1.32004370
57MP0001188_hyperpigmentation1.30928303
58MP0002184_abnormal_innervation1.28908054
59MP0008872_abnormal_physiological_respon1.28837053
60MP0004142_abnormal_muscle_tone1.27858757
61MP0008877_abnormal_DNA_methylation1.25335302
62MP0005174_abnormal_tail_pigmentation1.24960085
63MP0003879_abnormal_hair_cell1.24205336
64MP0004811_abnormal_neuron_physiology1.22107641
65MP0008775_abnormal_heart_ventricle1.21090409
66MP0003786_premature_aging1.19034594
67MP0003631_nervous_system_phenotype1.18168220
68MP0004858_abnormal_nervous_system1.17242342
69MP0000015_abnormal_ear_pigmentation1.16525635
70MP0003195_calcinosis1.16388643
71MP0003186_abnormal_redox_activity1.15693015
72MP0006035_abnormal_mitochondrial_morpho1.15481876
73MP0002557_abnormal_social/conspecific_i1.14869287
74MP0000465_gastrointestinal_hemorrhage1.13637859
75MP0005535_abnormal_body_temperature1.13173013
76MP0002066_abnormal_motor_capabilities/c1.09668476
77MP0008875_abnormal_xenobiotic_pharmacok1.04237161
78MP0002229_neurodegeneration1.03762867
79MP0008260_abnormal_autophagy1.01651496
80MP0000013_abnormal_adipose_tissue1.00342926
81MP0002166_altered_tumor_susceptibility1.00294118
82MP0003806_abnormal_nucleotide_metabolis0.99380887
83MP0003763_abnormal_thymus_physiology0.98480717
84MP0003121_genomic_imprinting0.98364141
85MP0004147_increased_porphyrin_level0.97638427
86MP0004742_abnormal_vestibular_system0.97291732
87MP0004145_abnormal_muscle_electrophysio0.96882571
88MP0002095_abnormal_skin_pigmentation0.96597445
89MP0000372_irregular_coat_pigmentation0.96405636
90MP0000778_abnormal_nervous_system0.96376627
91MP0006082_CNS_inflammation0.96036787
92MP0002163_abnormal_gland_morphology0.94325933
93MP0003646_muscle_fatigue0.92684640
94MP0003252_abnormal_bile_duct0.92520598
95MP0001835_abnormal_antigen_presentation0.91455981
96MP0008057_abnormal_DNA_replication0.91341403
97MP0005167_abnormal_blood-brain_barrier0.89913162
98MP0008874_decreased_physiological_sensi0.88746056
99MP0002882_abnormal_neuron_morphology0.87489988
100MP0000427_abnormal_hair_cycle0.87302920
101MP0001929_abnormal_gametogenesis0.85917785
102MP0005645_abnormal_hypothalamus_physiol0.85809967
103MP0000955_abnormal_spinal_cord0.85569106
104MP0000689_abnormal_spleen_morphology0.85287371
105MP0005423_abnormal_somatic_nervous0.85221520
106MP0003632_abnormal_nervous_system0.85110825
107MP0002909_abnormal_adrenal_gland0.84627997
108MP0004885_abnormal_endolymph0.84399979
109MP0000631_abnormal_neuroendocrine_gland0.83387165
110MP0000920_abnormal_myelination0.82774653
111MP0005551_abnormal_eye_electrophysiolog0.82514853
112MP0003567_abnormal_fetal_cardiomyocyte0.80310067
113MP0003656_abnormal_erythrocyte_physiolo0.80290639
114MP0000230_abnormal_systemic_arterial0.80209003
115MP0004510_myositis0.79951424
116MP0002751_abnormal_autonomic_nervous0.79545876
117MP0006036_abnormal_mitochondrial_physio0.79469022
118MP0001963_abnormal_hearing_physiology0.78895103
119MP0002398_abnormal_bone_marrow0.78380571
120MP0001502_abnormal_circadian_rhythm0.77437757
121MP0005387_immune_system_phenotype0.77200675
122MP0001790_abnormal_immune_system0.77200675
123MP0005389_reproductive_system_phenotype0.77049806
124MP0005000_abnormal_immune_tolerance0.76634685
125MP0004484_altered_response_of0.75993883
126MP0001873_stomach_inflammation0.75933834
127MP0005379_endocrine/exocrine_gland_phen0.75650642
128MP0005310_abnormal_salivary_gland0.74662092
129MP0002069_abnormal_eating/drinking_beha0.74018167
130MP0000516_abnormal_urinary_system0.73984289
131MP0005367_renal/urinary_system_phenotyp0.73984289
132MP0002006_tumorigenesis0.73948188
133MP0002638_abnormal_pupillary_reflex0.73901069
134MP0003724_increased_susceptibility_to0.73401290
135MP0000653_abnormal_sex_gland0.73337329
136MP0003698_abnormal_male_reproductive0.73247704
137MP0001800_abnormal_humoral_immune0.72569794
138MP0003137_abnormal_impulse_conducting0.72402020
139MP0002148_abnormal_hypersensitivity_rea0.72392508
140MP0004043_abnormal_pH_regulation0.72342763
141MP0001764_abnormal_homeostasis0.71933241
142MP0003122_maternal_imprinting0.71126032
143MP0010094_abnormal_chromosome_stability0.70857577
144MP0004085_abnormal_heartbeat0.70830606
145MP0009785_altered_susceptibility_to0.69163079
146MP0000685_abnormal_immune_system0.67667780
147MP0002420_abnormal_adaptive_immunity0.66656522
148MP0004036_abnormal_muscle_relaxation0.66656513
149MP0001819_abnormal_immune_cell0.65006783
150MP0002723_abnormal_immune_serum0.63030540

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.20625409
2Atonic seizures (HP:0010819)5.15449670
3Febrile seizures (HP:0002373)4.55510903
4Abnormal hair whorl (HP:0010721)4.36805819
5Epileptic encephalopathy (HP:0200134)4.19608673
6Abnormal mitochondria in muscle tissue (HP:0008316)4.10031333
7Acute necrotizing encephalopathy (HP:0006965)3.93285906
8Focal seizures (HP:0007359)3.85903336
9Hypothermia (HP:0002045)3.77263917
10Hyperventilation (HP:0002883)3.73385957
11Myokymia (HP:0002411)3.71364111
12Absence seizures (HP:0002121)3.55587015
13Neuroendocrine neoplasm (HP:0100634)3.52195706
14Progressive macrocephaly (HP:0004481)3.51329102
15Medial flaring of the eyebrow (HP:0010747)3.49028800
16Pheochromocytoma (HP:0002666)3.41972842
17Dialeptic seizures (HP:0011146)3.28938185
18Gait imbalance (HP:0002141)3.25375334
19Nephrogenic diabetes insipidus (HP:0009806)3.19571786
20Congenital primary aphakia (HP:0007707)3.17884681
21Acute encephalopathy (HP:0006846)3.15962059
22Mitochondrial inheritance (HP:0001427)3.13204614
23Pancreatic cysts (HP:0001737)3.13082406
24Hepatocellular necrosis (HP:0001404)3.07233388
25Gaze-evoked nystagmus (HP:0000640)3.04596396
26Abnormality of glycolysis (HP:0004366)3.00216089
27Increased serum pyruvate (HP:0003542)3.00216089
28Truncal ataxia (HP:0002078)2.99363190
29Progressive inability to walk (HP:0002505)2.98447458
30Renal cortical cysts (HP:0000803)2.95721205
31Methylmalonic acidemia (HP:0002912)2.91362481
32Visual hallucinations (HP:0002367)2.90384529
33Thyroiditis (HP:0100646)2.88003671
34Pancreatic fibrosis (HP:0100732)2.80991167
353-Methylglutaconic aciduria (HP:0003535)2.80742419
36Generalized tonic-clonic seizures (HP:0002069)2.80243739
37Progressive cerebellar ataxia (HP:0002073)2.75839838
38Abnormality of the renal cortex (HP:0011035)2.71250618
39Increased CSF lactate (HP:0002490)2.68546008
40Diplopia (HP:0000651)2.68499128
41Abnormality of binocular vision (HP:0011514)2.68499128
42True hermaphroditism (HP:0010459)2.65553356
43Stomach cancer (HP:0012126)2.64284633
44Increased IgM level (HP:0003496)2.52860925
45Molar tooth sign on MRI (HP:0002419)2.48862708
46Abnormality of midbrain morphology (HP:0002418)2.48862708
47Oligomenorrhea (HP:0000876)2.46931191
48Abnormality of the labia minora (HP:0012880)2.44172261
49Genital tract atresia (HP:0001827)2.43424506
50Poor coordination (HP:0002370)2.42838018
51Cerebral edema (HP:0002181)2.42368318
52Prolonged bleeding time (HP:0003010)2.41608024
53Inability to walk (HP:0002540)2.40632833
54Volvulus (HP:0002580)2.36810922
55Vaginal atresia (HP:0000148)2.36340903
56Abnormality of B cell number (HP:0010975)2.35723366
57Stomatitis (HP:0010280)2.35221848
58Leukodystrophy (HP:0002415)2.33403266
59Abolished electroretinogram (ERG) (HP:0000550)2.32867203
60Dyschromatopsia (HP:0007641)2.30353898
61Hepatic necrosis (HP:0002605)2.28385478
62Blue irides (HP:0000635)2.27293187
63Abnormality of the corticospinal tract (HP:0002492)2.27167554
64Optic disc pallor (HP:0000543)2.27126689
65Panhypogammaglobulinemia (HP:0003139)2.26593781
66Cerebral hemorrhage (HP:0001342)2.20788584
67Congenital stationary night blindness (HP:0007642)2.19101436
68Abnormality of aspartate family amino acid metabolism (HP:0010899)2.18210784
69Nephronophthisis (HP:0000090)2.17694860
70Abnormal eating behavior (HP:0100738)2.17642548
71Absent/shortened dynein arms (HP:0200106)2.16931730
72Dynein arm defect of respiratory motile cilia (HP:0012255)2.16931730
73Increased hepatocellular lipid droplets (HP:0006565)2.16254864
74IgG deficiency (HP:0004315)2.15573560
75Lipid accumulation in hepatocytes (HP:0006561)2.15509912
76Lactic acidosis (HP:0003128)2.15207641
77Polyphagia (HP:0002591)2.14920110
78Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.13627740
79Decreased activity of mitochondrial respiratory chain (HP:0008972)2.13627740
80Methylmalonic aciduria (HP:0012120)2.11972870
81Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.10729651
82Degeneration of the lateral corticospinal tracts (HP:0002314)2.10729651
83Impaired vibration sensation in the lower limbs (HP:0002166)2.09639866
84Hypoproteinemia (HP:0003075)2.08765272
85Epileptiform EEG discharges (HP:0011182)2.06036973
86Anxiety (HP:0000739)2.05555606
87Specific learning disability (HP:0001328)2.04481835
88Abnormality of vitamin B metabolism (HP:0004340)2.04056626
89Abnormality of the renal medulla (HP:0100957)2.03895496
90Abnormality of the vitamin B12 metabolism (HP:0004341)2.03385766
91Decreased central vision (HP:0007663)2.02580185
92Tubulointerstitial nephritis (HP:0001970)2.02484149
93Action tremor (HP:0002345)1.98709692
94B lymphocytopenia (HP:0010976)1.96749571
95Colon cancer (HP:0003003)1.96367494
96Broad-based gait (HP:0002136)1.95847770
97Poor suck (HP:0002033)1.95028520
98Urinary bladder sphincter dysfunction (HP:0002839)1.94085258
99Limb dystonia (HP:0002451)1.93516429
100Attenuation of retinal blood vessels (HP:0007843)1.93247401
101Abnormality of methionine metabolism (HP:0010901)1.92279123
102Petechiae (HP:0000967)1.91478643
103Resting tremor (HP:0002322)1.90648389
104Akinesia (HP:0002304)1.90550123
105Scanning speech (HP:0002168)1.88972054
106Spastic gait (HP:0002064)1.88593828
107Abnormality of the prostate (HP:0008775)1.87590342
108Type I transferrin isoform profile (HP:0003642)1.87053636
109Bile duct proliferation (HP:0001408)1.86857234
110Abnormal biliary tract physiology (HP:0012439)1.86857234
111Abnormality of eosinophils (HP:0001879)1.86689061
112Insidious onset (HP:0003587)1.86611808
113Termporal pattern (HP:0011008)1.86611808
114Cholecystitis (HP:0001082)1.86401952
115Abnormal gallbladder physiology (HP:0012438)1.86401952
116Hypomagnesemia (HP:0002917)1.86022222
117Bradykinesia (HP:0002067)1.85898443
118Chronic hepatic failure (HP:0100626)1.85772466
119Exercise intolerance (HP:0003546)1.85559751
120Poor speech (HP:0002465)1.85496416
121Fetal akinesia sequence (HP:0001989)1.85457478
122EEG with generalized epileptiform discharges (HP:0011198)1.84829136
123Renal Fanconi syndrome (HP:0001994)1.84661335
124Hyperglycinemia (HP:0002154)1.84228956
125Abnormality of T cell number (HP:0011839)1.83698437
126Combined immunodeficiency (HP:0005387)1.83674107
127Failure to thrive in infancy (HP:0001531)1.83520395
128Fair hair (HP:0002286)1.83362750
129Abnormality of the heme biosynthetic pathway (HP:0010472)1.82308858
130Poor eye contact (HP:0000817)1.80495349
131Impaired vibratory sensation (HP:0002495)1.80211669
132Acute hepatic failure (HP:0006554)1.80135676
133Menstrual irregularities (HP:0000858)1.79535356
134Lethargy (HP:0001254)1.79310996
135Optic nerve hypoplasia (HP:0000609)1.78638172
136Aplastic anemia (HP:0001915)1.78149958
137X-linked dominant inheritance (HP:0001423)1.77698297
138Depression (HP:0000716)1.77659835
139Ulnar claw (HP:0001178)1.76759448
140Abnormal social behavior (HP:0012433)1.76626560
141Impaired social interactions (HP:0000735)1.76626560
142Autoimmune hemolytic anemia (HP:0001890)1.75417407
143Abnormality of ocular smooth pursuit (HP:0000617)1.75294442
144Type II lissencephaly (HP:0007260)1.74621639
145Hypsarrhythmia (HP:0002521)1.73958593
146Intestinal atresia (HP:0011100)1.73170781
147Severe combined immunodeficiency (HP:0004430)1.72763578
148Spinal canal stenosis (HP:0003416)1.71857187
149T lymphocytopenia (HP:0005403)1.71657046
150Increased intramyocellular lipid droplets (HP:0012240)1.71278335
151Abnormality of alanine metabolism (HP:0010916)1.71244428
152Hyperalaninemia (HP:0003348)1.71244428
153Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.71244428
154Abnormal protein N-linked glycosylation (HP:0012347)1.69423636
155Abnormal protein glycosylation (HP:0012346)1.69423636
156Abnormal glycosylation (HP:0012345)1.69423636
157Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.69423636
158Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.68295123
159Abnormality of T cells (HP:0002843)1.68124772
160Increased serum lactate (HP:0002151)1.67184930
161Congenital, generalized hypertrichosis (HP:0004540)1.65495456
162Decreased electroretinogram (ERG) amplitude (HP:0000654)1.63219392
163Eosinophilia (HP:0001880)1.62093949

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.36580811
2MAP3K124.39869621
3CASK3.91514029
4FRK3.59976039
5TXK3.06259100
6NTRK32.81009965
7MAP2K72.69928140
8TAOK32.69454112
9MAP4K22.66578033
10MAP3K42.55625806
11NUAK12.53157568
12TRIM282.37243013
13PDK42.20922678
14PDK32.20922678
15ACVR1B2.20809090
16WNK32.10002842
17TSSK62.00193860
18ZAK1.83854808
19EIF2AK31.81341554
20PLK21.75516506
21ERBB31.71067587
22PRPF4B1.70422721
23EPHA41.70001700
24RIPK41.69509907
25ARAF1.65184527
26MAP3K91.63349282
27MAP3K131.62767760
28BRSK21.60531154
29MINK11.59141560
30SIK31.55290541
31PDK21.53358723
32MAP2K41.51694306
33BCKDK1.50210172
34STK161.41581095
35NTRK21.40384270
36EIF2AK11.36791598
37BCR1.33149314
38LMTK21.33015855
39DAPK11.31771619
40BMPR21.28679568
41MKNK21.27668852
42SGK21.25831647
43MAP3K141.23900490
44PIK3CG1.23498529
45GRK51.21742919
46MKNK11.20252291
47PLK31.18862155
48INSRR1.17389966
49VRK11.17020242
50MST41.16272027
51MAP4K11.15928015
52SGK2231.13452721
53SGK4941.13452721
54BMPR1B1.09986633
55TEC1.08518097
56PAK31.07020560
57CDK191.06807525
58DAPK21.06050679
59OBSCN1.05065018
60FGFR21.03158307
61NLK1.03023916
62OXSR11.02593109
63PRKCG0.96174806
64BTK0.94921532
65CAMKK20.91291471
66CCNB10.88716549
67MYLK0.86024239
68FGFR40.85830274
69FER0.84893914
70JAK30.84651897
71PTK2B0.84208829
72KSR20.81324308
73SGK30.80971907
74PINK10.80922845
75AKT30.80294851
76SYK0.79193911
77PLK40.79159080
78GRK70.78034765
79ITK0.76541211
80CDK50.74130536
81CAMK2A0.72546520
82FGR0.70681295
83MAPK130.70474466
84CAMK2B0.70335161
85NTRK10.68944024
86PRKCQ0.68257533
87LYN0.68085972
88PRKCE0.67346562
89WEE10.66226033
90GRK60.66195323
91NEK60.65682776
92TNK20.65267971
93GRK10.64317391
94WNK40.64148791
95IKBKE0.63445917
96MAPKAPK30.63263357
97CSNK1G10.63010451
98LIMK10.61754918
99NME10.61351652
100JAK10.61042308
101STK30.59907646
102PDK10.59599779
103CSNK1G20.58436136
104MARK10.57438891
105BRAF0.57154064
106PRKCH0.55388563
107KIT0.55340758
108DYRK1A0.55328666
109SRPK10.54924591
110MAP3K20.52727520
111CSNK1G30.52668909
112MUSK0.52533674
113TLK10.52190125
114EIF2AK20.51943744
115DYRK20.51399967
116ERBB40.50955718
117STK38L0.50082748
118ADRBK20.49337046
119FGFR30.49124711
120LCK0.48735722
121KSR10.48599790
122NEK10.47923672
123VRK20.47391288
124IKBKB0.47047457
125PIK3CA0.46400767
126TGFBR10.45835536
127HCK0.44349568
128ATR0.42534155
129PDPK10.41693130
130RPS6KA40.41128640
131RPS6KA50.41102991
132PRKG10.40948591
133RAF10.40347565
134ATM0.39716273
135CDK80.39326254
136ZAP700.35754164
137TNIK0.35506618
138RET0.34912238
139STK390.34794202
140CAMK2G0.34756195
141MAPK70.34632393
142CDK180.34254848
143ADRBK10.34086691
144PHKG20.32411480
145PHKG10.32411480
146FES0.31626215
147PKN10.31571552
148MAPK120.31414342
149MAP2K10.29378374
150PNCK0.29057166

Predicted pathways (KEGG)

RankGene SetZ-score
1Synaptic vesicle cycle_Homo sapiens_hsa047213.74035328
2Collecting duct acid secretion_Homo sapiens_hsa049663.45477655
3Nicotine addiction_Homo sapiens_hsa050333.36540888
4Protein export_Homo sapiens_hsa030602.92915886
5Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.50749002
6Oxidative phosphorylation_Homo sapiens_hsa001902.40210762
7Nitrogen metabolism_Homo sapiens_hsa009102.30149911
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.24049196
9Olfactory transduction_Homo sapiens_hsa047402.22032780
10Non-homologous end-joining_Homo sapiens_hsa034502.15383921
11Rheumatoid arthritis_Homo sapiens_hsa053232.15251453
12Taste transduction_Homo sapiens_hsa047422.13791899
13Morphine addiction_Homo sapiens_hsa050322.11578311
14GABAergic synapse_Homo sapiens_hsa047272.01618817
15Vibrio cholerae infection_Homo sapiens_hsa051102.01162992
16Homologous recombination_Homo sapiens_hsa034401.93424719
17Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.91256429
18Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.90125233
19Long-term potentiation_Homo sapiens_hsa047201.89047488
20Basal transcription factors_Homo sapiens_hsa030221.76093256
21Circadian entrainment_Homo sapiens_hsa047131.75212993
22Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.70713580
23Pyruvate metabolism_Homo sapiens_hsa006201.68915255
24RNA polymerase_Homo sapiens_hsa030201.68552275
25Fanconi anemia pathway_Homo sapiens_hsa034601.68471217
26Type I diabetes mellitus_Homo sapiens_hsa049401.67648276
27Amphetamine addiction_Homo sapiens_hsa050311.66516449
28Parkinsons disease_Homo sapiens_hsa050121.66353526
29Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.59358979
30Linoleic acid metabolism_Homo sapiens_hsa005911.58978210
31Mismatch repair_Homo sapiens_hsa034301.58556800
32RNA degradation_Homo sapiens_hsa030181.56918186
33Primary immunodeficiency_Homo sapiens_hsa053401.52440959
34Glutamatergic synapse_Homo sapiens_hsa047241.49323978
35Alzheimers disease_Homo sapiens_hsa050101.48230346
36Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.47873128
37Salivary secretion_Homo sapiens_hsa049701.44033105
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.41071108
39Serotonergic synapse_Homo sapiens_hsa047261.40970238
40Dopaminergic synapse_Homo sapiens_hsa047281.40239923
41Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.39713452
42Allograft rejection_Homo sapiens_hsa053301.39465253
43Renin secretion_Homo sapiens_hsa049241.36843553
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.32471068
45Insulin secretion_Homo sapiens_hsa049111.31941810
46Primary bile acid biosynthesis_Homo sapiens_hsa001201.30967895
47Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.25403883
48SNARE interactions in vesicular transport_Homo sapiens_hsa041301.24651770
49Autoimmune thyroid disease_Homo sapiens_hsa053201.24279831
50Proteasome_Homo sapiens_hsa030501.23850631
51Graft-versus-host disease_Homo sapiens_hsa053321.17962735
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17933067
53Calcium signaling pathway_Homo sapiens_hsa040201.14562157
54Propanoate metabolism_Homo sapiens_hsa006401.14543330
55Cholinergic synapse_Homo sapiens_hsa047251.13167642
56Regulation of autophagy_Homo sapiens_hsa041401.11568535
57Caffeine metabolism_Homo sapiens_hsa002321.08991720
58Tryptophan metabolism_Homo sapiens_hsa003801.08348719
59Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.08006834
60Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.07372284
61Gastric acid secretion_Homo sapiens_hsa049711.07008885
62Maturity onset diabetes of the young_Homo sapiens_hsa049501.05448230
63Platelet activation_Homo sapiens_hsa046111.05115838
64Asthma_Homo sapiens_hsa053101.03953589
65Long-term depression_Homo sapiens_hsa047301.01751942
66Fatty acid elongation_Homo sapiens_hsa000621.00825621
67Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.99850476
68Ether lipid metabolism_Homo sapiens_hsa005650.99454094
69Purine metabolism_Homo sapiens_hsa002300.99246303
70Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.98457142
71Circadian rhythm_Homo sapiens_hsa047100.98161198
72T cell receptor signaling pathway_Homo sapiens_hsa046600.97752062
73Aldosterone synthesis and secretion_Homo sapiens_hsa049250.97663991
74Phosphatidylinositol signaling system_Homo sapiens_hsa040700.96993564
75Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95548081
76Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95236903
77Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.94010063
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.93778099
79Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.92167382
80Huntingtons disease_Homo sapiens_hsa050160.91612003
81Selenocompound metabolism_Homo sapiens_hsa004500.90570975
82Phagosome_Homo sapiens_hsa041450.87989923
83Oxytocin signaling pathway_Homo sapiens_hsa049210.87584186
84Arachidonic acid metabolism_Homo sapiens_hsa005900.86164059
85Chemical carcinogenesis_Homo sapiens_hsa052040.85441692
86Butanoate metabolism_Homo sapiens_hsa006500.84973874
87Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83862461
88Hematopoietic cell lineage_Homo sapiens_hsa046400.79573122
89Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.78992109
90Cocaine addiction_Homo sapiens_hsa050300.77767144
91Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.77713820
92beta-Alanine metabolism_Homo sapiens_hsa004100.77581302
932-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.76748545
94Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.76005717
95Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.74644414
96African trypanosomiasis_Homo sapiens_hsa051430.71780447
97One carbon pool by folate_Homo sapiens_hsa006700.68624066
98Steroid hormone biosynthesis_Homo sapiens_hsa001400.68079030
99Retinol metabolism_Homo sapiens_hsa008300.67825223
100Intestinal immune network for IgA production_Homo sapiens_hsa046720.66507881
101RNA transport_Homo sapiens_hsa030130.65784473
102Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.64474405
103Fatty acid degradation_Homo sapiens_hsa000710.63310233
104Cardiac muscle contraction_Homo sapiens_hsa042600.63082304
105Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.62451234
106Fatty acid metabolism_Homo sapiens_hsa012120.61331954
107Vitamin B6 metabolism_Homo sapiens_hsa007500.59791614
108Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.59533216
109cAMP signaling pathway_Homo sapiens_hsa040240.56601585
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.56047302
111ABC transporters_Homo sapiens_hsa020100.54829905
112Phenylalanine metabolism_Homo sapiens_hsa003600.54739378
113Nucleotide excision repair_Homo sapiens_hsa034200.54604802
114Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.54562958
115Pyrimidine metabolism_Homo sapiens_hsa002400.53980188
116Metabolic pathways_Homo sapiens_hsa011000.50864103
117GnRH signaling pathway_Homo sapiens_hsa049120.49500491
118Glucagon signaling pathway_Homo sapiens_hsa049220.49106347
119Carbon metabolism_Homo sapiens_hsa012000.46000840
120Phototransduction_Homo sapiens_hsa047440.45683166
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.45585274
122Sulfur metabolism_Homo sapiens_hsa009200.45350165
123ErbB signaling pathway_Homo sapiens_hsa040120.44938413
124Pentose and glucuronate interconversions_Homo sapiens_hsa000400.44873857
125Inositol phosphate metabolism_Homo sapiens_hsa005620.44821887
126Base excision repair_Homo sapiens_hsa034100.43990541
127Gap junction_Homo sapiens_hsa045400.43925520
128Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.42900832
129Systemic lupus erythematosus_Homo sapiens_hsa053220.42128671
130Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.42119030
131Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.40496944
132cGMP-PKG signaling pathway_Homo sapiens_hsa040220.40409842
133Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40325534
134Type II diabetes mellitus_Homo sapiens_hsa049300.40132137
135Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.38503881
136Fructose and mannose metabolism_Homo sapiens_hsa000510.38193763
137Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.38164638
138Glycerolipid metabolism_Homo sapiens_hsa005610.37486089
139Peroxisome_Homo sapiens_hsa041460.35167381
140Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.31860510
141Chemokine signaling pathway_Homo sapiens_hsa040620.31773203
142Ras signaling pathway_Homo sapiens_hsa040140.31502363
143Tyrosine metabolism_Homo sapiens_hsa003500.30549257
144Endocytosis_Homo sapiens_hsa041440.29659151
145Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.27397086
146Pancreatic secretion_Homo sapiens_hsa049720.26003492
147Measles_Homo sapiens_hsa051620.25668265
148MAPK signaling pathway_Homo sapiens_hsa040100.24622264
149Choline metabolism in cancer_Homo sapiens_hsa052310.23341187
150Estrogen signaling pathway_Homo sapiens_hsa049150.22416200
151Cysteine and methionine metabolism_Homo sapiens_hsa002700.21996426
152Oocyte meiosis_Homo sapiens_hsa041140.21333101

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