CRCP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proteasome assembly (GO:0043248)5.60587007
2negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)4.87963073
3behavioral response to nicotine (GO:0035095)4.72309847
4regulation of cellular amino acid metabolic process (GO:0006521)4.72245492
5positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)4.58697723
6purine nucleobase biosynthetic process (GO:0009113)4.55163092
7regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)4.48667402
8termination of RNA polymerase III transcription (GO:0006386)4.47716426
9transcription elongation from RNA polymerase III promoter (GO:0006385)4.47716426
10negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.45145009
11negative regulation of ligase activity (GO:0051352)4.45145009
12DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:004.39302923
13anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:04.38805710
14intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)4.30216180
15signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)4.30216180
16signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)4.27354262
17signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)4.27354262
18signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)4.27354262
19cullin deneddylation (GO:0010388)4.26257994
20antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:4.26143590
21nucleobase biosynthetic process (GO:0046112)4.24396246
22DNA deamination (GO:0045006)4.23866720
23signal transduction involved in DNA damage checkpoint (GO:0072422)4.16811022
24signal transduction involved in DNA integrity checkpoint (GO:0072401)4.16811022
25protein deneddylation (GO:0000338)4.16383327
26signal transduction involved in cell cycle checkpoint (GO:0072395)4.13970791
277-methylguanosine mRNA capping (GO:0006370)4.08507060
28positive regulation of ubiquitin-protein transferase activity (GO:0051443)4.04354336
29formation of translation preinitiation complex (GO:0001731)4.00870269
30RNA capping (GO:0036260)4.00612768
317-methylguanosine RNA capping (GO:0009452)4.00612768
32response to pheromone (GO:0019236)3.97518221
33antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)3.97422089
34chaperone-mediated protein transport (GO:0072321)3.93945578
35water-soluble vitamin biosynthetic process (GO:0042364)3.91084743
36positive regulation of ligase activity (GO:0051351)3.85509632
37mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.70198756
38ribosome biogenesis (GO:0042254)3.65795197
39L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.63901302
40amino acid salvage (GO:0043102)3.61418982
41L-methionine salvage (GO:0071267)3.61418982
42L-methionine biosynthetic process (GO:0071265)3.61418982
43regulation of nuclear cell cycle DNA replication (GO:0033262)3.60303172
44regulation of ubiquitin-protein transferase activity (GO:0051438)3.58842540
45regulation of cellular amine metabolic process (GO:0033238)3.58055129
46protein K6-linked ubiquitination (GO:0085020)3.56671824
47DNA damage response, detection of DNA damage (GO:0042769)3.53556811
48protein targeting to mitochondrion (GO:0006626)3.52404042
49establishment of protein localization to mitochondrial membrane (GO:0090151)3.52123794
50preassembly of GPI anchor in ER membrane (GO:0016254)3.49608715
51mannosylation (GO:0097502)3.45928539
52establishment of protein localization to mitochondrion (GO:0072655)3.45245184
53regulation of ligase activity (GO:0051340)3.44989103
54guanosine-containing compound biosynthetic process (GO:1901070)3.38661261
55fucose catabolic process (GO:0019317)3.37061113
56L-fucose metabolic process (GO:0042354)3.37061113
57L-fucose catabolic process (GO:0042355)3.37061113
58DNA damage response, signal transduction by p53 class mediator (GO:0030330)3.34710335
59respiratory chain complex IV assembly (GO:0008535)3.34663315
60positive regulation of cell cycle arrest (GO:0071158)3.34479149
61antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)3.32241562
62positive regulation of protein homodimerization activity (GO:0090073)3.29700066
63energy coupled proton transport, down electrochemical gradient (GO:0015985)3.28686863
64ATP synthesis coupled proton transport (GO:0015986)3.28686863
65mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.27976241
66mitochondrial respiratory chain complex I assembly (GO:0032981)3.27976241
67NADH dehydrogenase complex assembly (GO:0010257)3.27976241
68regulation of hippo signaling (GO:0035330)3.27573104
69ribosome assembly (GO:0042255)3.27086882
70rRNA modification (GO:0000154)3.24548364
71protein-cofactor linkage (GO:0018065)3.23855470
72mitotic metaphase plate congression (GO:0007080)3.23289638
73protein localization to mitochondrion (GO:0070585)3.22855887
74G1/S transition of mitotic cell cycle (GO:0000082)3.22278256
75cell cycle G1/S phase transition (GO:0044843)3.22278256
76cellular ketone body metabolic process (GO:0046950)3.17431045
77tRNA processing (GO:0008033)3.14969291
78deoxyribose phosphate biosynthetic process (GO:0046385)3.13124316
792-deoxyribonucleotide biosynthetic process (GO:0009265)3.13124316
80protein neddylation (GO:0045116)3.12661867
81transcription elongation from RNA polymerase II promoter (GO:0006368)3.12070042
82kynurenine metabolic process (GO:0070189)3.10205316
83ribonucleoprotein complex biogenesis (GO:0022613)3.08968441
84spliceosomal snRNP assembly (GO:0000387)3.07346764
85tRNA modification (GO:0006400)3.05267712
86cytochrome complex assembly (GO:0017004)3.00822197
87tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.00414716
88RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.00414716
89deoxyribonucleotide biosynthetic process (GO:0009263)2.99844458
90negative regulation of protein ubiquitination (GO:0031397)2.98824239
91maturation of 5.8S rRNA (GO:0000460)2.98792304
92DNA-templated transcription, elongation (GO:0006354)2.98374319
93transcription-coupled nucleotide-excision repair (GO:0006283)2.98363600
94mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.96958503
95DNA replication checkpoint (GO:0000076)2.96866884
96transcription elongation from RNA polymerase I promoter (GO:0006362)2.95562119
97establishment of integrated proviral latency (GO:0075713)2.94475222
98cellular component biogenesis (GO:0044085)2.94386552
99maturation of SSU-rRNA (GO:0030490)2.93688503
100mitochondrial RNA metabolic process (GO:0000959)2.92618282
101signal transduction in response to DNA damage (GO:0042770)2.92562627
102ribosomal small subunit assembly (GO:0000028)2.92488324
103protein complex biogenesis (GO:0070271)2.91984803
104de novo protein folding (GO:0006458)2.91609053
105nucleobase-containing small molecule interconversion (GO:0015949)2.91345876
106GTP biosynthetic process (GO:0006183)2.91107740
107oxidative phosphorylation (GO:0006119)2.89974338
108negative regulation of cell cycle G1/S phase transition (GO:1902807)2.89758750
109negative regulation of G1/S transition of mitotic cell cycle (GO:2000134)2.89758750
110de novo posttranslational protein folding (GO:0051084)2.89737766
111rRNA processing (GO:0006364)2.89533458
112DNA strand elongation involved in DNA replication (GO:0006271)2.87030805
113nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.86923855
114exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.86405024
115transcription from RNA polymerase I promoter (GO:0006360)2.86392089
116pseudouridine synthesis (GO:0001522)2.85925412
117recombinational repair (GO:0000725)2.85237757
118deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.83343654
119termination of RNA polymerase I transcription (GO:0006363)2.83332763
120rRNA metabolic process (GO:0016072)2.81988329
121translation (GO:0006412)2.81758565
122tRNA methylation (GO:0030488)2.81687746
123tRNA metabolic process (GO:0006399)2.81397323
124mitochondrial respiratory chain complex assembly (GO:0033108)2.80918485
125double-strand break repair via homologous recombination (GO:0000724)2.80058159
126deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.80051886
127ribosomal large subunit biogenesis (GO:0042273)2.79971287
128peptidyl-histidine modification (GO:0018202)2.79113226
129electron transport chain (GO:0022900)2.78449212
130DNA double-strand break processing (GO:0000729)2.77122878
131protein localization to cilium (GO:0061512)2.75937627
132negative regulation of telomere maintenance (GO:0032205)2.75164397
133ncRNA processing (GO:0034470)2.71185141
134phenylpropanoid metabolic process (GO:0009698)2.71131215
135negative regulation of T cell differentiation in thymus (GO:0033085)2.70199120
136replication fork processing (GO:0031297)2.68266663
137transcription initiation from RNA polymerase I promoter (GO:0006361)2.68056516
138rRNA methylation (GO:0031167)2.68050665
139folic acid-containing compound biosynthetic process (GO:0009396)2.67761287
140ketone body metabolic process (GO:1902224)2.65834787
141somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.64651142
142isotype switching (GO:0045190)2.64651142
143somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.64651142
144translational termination (GO:0006415)2.63230450
145C-terminal protein lipidation (GO:0006501)2.63221505
146ncRNA metabolic process (GO:0034660)2.63197406
147respiratory electron transport chain (GO:0022904)2.63118520
148ribosomal small subunit biogenesis (GO:0042274)2.57972675
149cotranslational protein targeting to membrane (GO:0006613)2.57839725
150phenol-containing compound catabolic process (GO:0019336)2.57283875
151regulation of DNA endoreduplication (GO:0032875)2.57166311
152viral transcription (GO:0019083)2.56705189
153regulation of hexokinase activity (GO:1903299)2.56601492
154regulation of glucokinase activity (GO:0033131)2.56601492
155telomere maintenance via telomerase (GO:0007004)2.56157893
156protein K11-linked deubiquitination (GO:0035871)2.56036319
157protein targeting to ER (GO:0045047)2.55752968
158methionine biosynthetic process (GO:0009086)2.53992625
159SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.53284825
160GPI anchor metabolic process (GO:0006505)2.52201817
161negative regulation of mast cell activation (GO:0033004)2.50153121
162pyrimidine nucleobase catabolic process (GO:0006208)2.49391254
163pteridine-containing compound biosynthetic process (GO:0042559)2.49218366

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.57528283
2JARID1A_20064375_ChIP-Seq_MESCs_Mouse4.25014433
3GABP_17652178_ChIP-ChIP_JURKAT_Human4.23640588
4EST1_17652178_ChIP-ChIP_JURKAT_Human4.11203173
5ZNF274_21170338_ChIP-Seq_K562_Hela3.94201201
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.84255923
7* MYC_18555785_ChIP-Seq_MESCs_Mouse3.83656174
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.73028011
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.66057663
10CREB1_15753290_ChIP-ChIP_HEK293T_Human3.64257432
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.50216176
12E2F7_22180533_ChIP-Seq_HELA_Human3.29769420
13HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.06600582
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00118581
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.88462942
16HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.85715504
17VDR_23849224_ChIP-Seq_CD4+_Human2.77750001
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.65819553
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.62128302
20CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.61875671
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.50110182
22* SRF_21415370_ChIP-Seq_HL-1_Mouse2.42242962
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.41472042
24DCP1A_22483619_ChIP-Seq_HELA_Human2.41238367
25PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.40627465
26MYC_19079543_ChIP-ChIP_MESCs_Mouse2.38413267
27FOXP3_21729870_ChIP-Seq_TREG_Human2.31672278
28GABP_19822575_ChIP-Seq_HepG2_Human2.25348188
29XRN2_22483619_ChIP-Seq_HELA_Human2.24577647
30YY1_21170310_ChIP-Seq_MESCs_Mouse2.21591476
31* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.20235158
32RBPJ_22232070_ChIP-Seq_NCS_Mouse2.18220374
33NELFA_20434984_ChIP-Seq_ESCs_Mouse2.15714822
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15016518
35CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.14324403
36IRF1_19129219_ChIP-ChIP_H3396_Human2.10259385
37E2F4_17652178_ChIP-ChIP_JURKAT_Human2.10147791
38FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse2.06725065
39ELK1_19687146_ChIP-ChIP_HELA_Human2.04333962
40FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.96328117
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.89263257
42VDR_22108803_ChIP-Seq_LS180_Human1.85260637
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85220829
44ER_23166858_ChIP-Seq_MCF-7_Human1.83465726
45ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.81287039
46HOXB4_20404135_ChIP-ChIP_EML_Mouse1.80854856
47CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.77031489
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.76274380
49CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.74833564
50TTF2_22483619_ChIP-Seq_HELA_Human1.73210040
51MYCN_18555785_ChIP-Seq_MESCs_Mouse1.72876758
52* EWS_26573619_Chip-Seq_HEK293_Human1.72410768
53YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67542928
54FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.61476830
55ESR1_15608294_ChIP-ChIP_MCF-7_Human1.56924722
56FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.51168651
57PADI4_21655091_ChIP-ChIP_MCF-7_Human1.48224921
58ELF5_23300383_ChIP-Seq_T47D_Human1.44725831
59BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43505421
60MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.37452939
61ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35822681
62FOXM1_23109430_ChIP-Seq_U2OS_Human1.33509619
63KDM5A_27292631_Chip-Seq_BREAST_Human1.32420656
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.31967448
65TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.30701548
66* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.28890118
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.27022393
68CIITA_25753668_ChIP-Seq_RAJI_Human1.24132319
69TP63_19390658_ChIP-ChIP_HaCaT_Human1.23951583
70ELK1_22589737_ChIP-Seq_MCF10A_Human1.22777193
71CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.20781465
72TP53_22573176_ChIP-Seq_HFKS_Human1.20734183
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.20713021
74TDRD3_21172665_ChIP-Seq_MCF-7_Human1.18428171
75* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.17946255
76SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.17075638
77HOXB7_26014856_ChIP-Seq_BT474_Human1.15427202
78CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.14170057
79TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.13355288
80E2F1_21310950_ChIP-Seq_MCF-7_Human1.13041031
81ESR1_20079471_ChIP-ChIP_T-47D_Human1.12533906
82CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.11915097
83AR_21909140_ChIP-Seq_LNCAP_Human1.10192679
84NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08630660
85SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.06378834
86ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.05575945
87NOTCH1_21737748_ChIP-Seq_TLL_Human1.04695883
88FLI1_27457419_Chip-Seq_LIVER_Mouse1.04238805
89SALL1_21062744_ChIP-ChIP_HESCs_Human1.04066823
90NANOG_18555785_ChIP-Seq_MESCs_Mouse1.03486443
91* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03354592
92EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.02638706
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.01838442
94IGF1R_20145208_ChIP-Seq_DFB_Human1.01114104
95IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.00683812
96CTBP2_25329375_ChIP-Seq_LNCAP_Human1.00294307
97CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.99027518
98MYC_18940864_ChIP-ChIP_HL60_Human0.98554038
99GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95558562
100ESR1_21235772_ChIP-Seq_MCF-7_Human0.95474792
101E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.95408383
102CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.95161109
103ZFP57_27257070_Chip-Seq_ESCs_Mouse0.92326012
104ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.91870412
105MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.90705572
106TAF15_26573619_Chip-Seq_HEK293_Human0.90059729
107KLF4_18555785_ChIP-Seq_MESCs_Mouse0.89855583
108TFEB_21752829_ChIP-Seq_HELA_Human0.89608130
109HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.88527034
110CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.88440535
111HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.88345898
112EGR1_23403033_ChIP-Seq_LIVER_Mouse0.88267592
113FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87936268
114CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83442425
115PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.82837708
116FOXA1_27270436_Chip-Seq_PROSTATE_Human0.82543420
117FOXA1_25329375_ChIP-Seq_VCAP_Human0.82543420
118STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82397355
119EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.80486136
120ERA_21632823_ChIP-Seq_H3396_Human0.80386072
121CTCF_18555785_ChIP-Seq_MESCs_Mouse0.80048778
122POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.79340590
123FOXP1_21924763_ChIP-Seq_HESCs_Human0.79081353
124FUS_26573619_Chip-Seq_HEK293_Human0.78977591
125GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.78489314
126DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.78452275
127* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.77779349
128ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.76844240
129TBX5_21415370_ChIP-Seq_HL-1_Mouse0.76717359
130IRF8_21731497_ChIP-ChIP_J774_Mouse0.76133899
131NCOR_22424771_ChIP-Seq_293T_Human0.76094345
132* SPI1_23547873_ChIP-Seq_NB4_Human0.75564703
133PKCTHETA_26484144_Chip-Seq_BREAST_Human0.75534810
134KAP1_22055183_ChIP-Seq_ESCs_Mouse0.72804000
135KDM5B_21448134_ChIP-Seq_MESCs_Mouse0.72560606
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.71244495
137SOX17_20123909_ChIP-Seq_XEN_Mouse0.70397429

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.44672275
2MP0004957_abnormal_blastocyst_morpholog3.65939070
3MP0003806_abnormal_nucleotide_metabolis3.51467841
4MP0008058_abnormal_DNA_repair3.06354025
5MP0002638_abnormal_pupillary_reflex2.85540585
6MP0003111_abnormal_nucleus_morphology2.80890180
7MP0010094_abnormal_chromosome_stability2.74332567
8MP0003718_maternal_effect2.74107911
9MP0000427_abnormal_hair_cycle2.69947118
10MP0003077_abnormal_cell_cycle2.60141426
11MP0009697_abnormal_copulation2.49993513
12MP0005423_abnormal_somatic_nervous2.45168977
13MP0006072_abnormal_retinal_apoptosis2.25756425
14MP0002139_abnormal_hepatobiliary_system2.22675535
15MP0006035_abnormal_mitochondrial_morpho2.22412539
16MP0008007_abnormal_cellular_replicative2.20702075
17MP0006036_abnormal_mitochondrial_physio2.15314655
18MP0008057_abnormal_DNA_replication2.14465531
19MP0008875_abnormal_xenobiotic_pharmacok2.05630192
20MP0001764_abnormal_homeostasis2.02610753
21MP0002822_catalepsy2.01293046
22MP0009333_abnormal_splenocyte_physiolog2.00265472
23MP0008877_abnormal_DNA_methylation2.00048272
24MP0003786_premature_aging1.98920536
25MP0005085_abnormal_gallbladder_physiolo1.98307601
26MP0005365_abnormal_bile_salt1.96121589
27MP0003186_abnormal_redox_activity1.94481577
28MP0002102_abnormal_ear_morphology1.85157321
29MP0008872_abnormal_physiological_respon1.80574952
30MP0001529_abnormal_vocalization1.78822052
31MP0008932_abnormal_embryonic_tissue1.78296608
32MP0008260_abnormal_autophagy1.77453885
33MP0005360_urolithiasis1.76335723
34MP0003656_abnormal_erythrocyte_physiolo1.74749798
35MP0005551_abnormal_eye_electrophysiolog1.71704968
36MP0001905_abnormal_dopamine_level1.71130699
37MP0001835_abnormal_antigen_presentation1.63376298
38MP0002736_abnormal_nociception_after1.60649894
39MP0005253_abnormal_eye_physiology1.59694003
40MP0006276_abnormal_autonomic_nervous1.59639057
41MP0002132_abnormal_respiratory_system1.59456054
42MP0001968_abnormal_touch/_nociception1.57680117
43MP0000358_abnormal_cell_content/1.57466802
44MP0005410_abnormal_fertilization1.55227102
45MP0003880_abnormal_central_pattern1.55140453
46MP0002938_white_spotting1.51135011
47MP0001730_embryonic_growth_arrest1.49126085
48MP0005379_endocrine/exocrine_gland_phen1.48876896
49MP0008995_early_reproductive_senescence1.41172435
50MP0003787_abnormal_imprinting1.40248078
51MP0005083_abnormal_biliary_tract1.37591215
52MP0000647_abnormal_sebaceous_gland1.36179051
53MP0001929_abnormal_gametogenesis1.31122467
54MP0002098_abnormal_vibrissa_morphology1.29305756
55MP0005671_abnormal_response_to1.28408831
56MP0001542_abnormal_bone_strength1.27346250
57MP0002735_abnormal_chemical_nociception1.27220980
58MP0006292_abnormal_olfactory_placode1.23761614
59MP0002876_abnormal_thyroid_physiology1.22517788
60MP0005408_hypopigmentation1.21538001
61MP0005636_abnormal_mineral_homeostasis1.20042536
62MP0002909_abnormal_adrenal_gland1.19760199
63MP0002163_abnormal_gland_morphology1.17265372
64MP0009840_abnormal_foam_cell1.15958142
65MP0002693_abnormal_pancreas_physiology1.15098482
66MP0000569_abnormal_digit_pigmentation1.14131963
67MP0005332_abnormal_amino_acid1.13989612
68MP0003011_delayed_dark_adaptation1.09086579
69MP0009046_muscle_twitch1.08791182
70MP0003221_abnormal_cardiomyocyte_apopto1.08435814
71MP0000538_abnormal_urinary_bladder1.08165601
72MP0010234_abnormal_vibrissa_follicle1.07909390
73MP0000350_abnormal_cell_proliferation1.07759575
74MP0009379_abnormal_foot_pigmentation1.07323552
75MP0002751_abnormal_autonomic_nervous1.06381325
76MP0004142_abnormal_muscle_tone1.05803697
77MP0004742_abnormal_vestibular_system1.05762688
78MP0002184_abnormal_innervation1.05347692
79MP0002210_abnormal_sex_determination1.05333207
80MP0005389_reproductive_system_phenotype1.04816043
81MP0003646_muscle_fatigue1.04796848
82MP0000313_abnormal_cell_death1.04678579
83MP0000383_abnormal_hair_follicle1.04573455
84MP0000631_abnormal_neuroendocrine_gland1.02742781
85MP0009745_abnormal_behavioral_response1.02081380
86MP0002254_reproductive_system_inflammat1.02021211
87MP0009785_altered_susceptibility_to1.01328899
88MP0001986_abnormal_taste_sensitivity1.01077646
89MP0001919_abnormal_reproductive_system1.00283483
90MP0000372_irregular_coat_pigmentation1.00252785
91MP0002009_preneoplasia0.99909646
92MP0002095_abnormal_skin_pigmentation0.99574019
93MP0010678_abnormal_skin_adnexa0.99287370
94MP0003698_abnormal_male_reproductive0.98390288
95MP0002160_abnormal_reproductive_system0.97490479
96MP0002928_abnormal_bile_duct0.96759202
97MP0000689_abnormal_spleen_morphology0.95762922
98MP0005174_abnormal_tail_pigmentation0.94989604
99MP0005319_abnormal_enzyme/_coenzyme0.94348628
100MP0002398_abnormal_bone_marrow0.94178166
101MP0005646_abnormal_pituitary_gland0.94080091
102MP0001944_abnormal_pancreas_morphology0.93636529
103MP0001727_abnormal_embryo_implantation0.93111088
104MP0001145_abnormal_male_reproductive0.93108938
105MP0003315_abnormal_perineum_morphology0.93039815
106MP0001881_abnormal_mammary_gland0.92928235
107MP0005075_abnormal_melanosome_morpholog0.92100027
108MP0001873_stomach_inflammation0.92082264
109MP0002019_abnormal_tumor_incidence0.92043475
110MP0005195_abnormal_posterior_eye0.91960819
111MP0002396_abnormal_hematopoietic_system0.91383078
112MP0004133_heterotaxia0.90710724
113MP0002080_prenatal_lethality0.90002551
114MP0005645_abnormal_hypothalamus_physiol0.89882242
115MP0003763_abnormal_thymus_physiology0.89678225
116MP0005376_homeostasis/metabolism_phenot0.89378181
117MP0001502_abnormal_circadian_rhythm0.88953479
118MP0008469_abnormal_protein_level0.88914750
119MP0004381_abnormal_hair_follicle0.88835373
120MP0005391_vision/eye_phenotype0.88795882
121MP0005397_hematopoietic_system_phenotyp0.87094646
122MP0001545_abnormal_hematopoietic_system0.87094646
123MP0003195_calcinosis0.85501843
124MP0004043_abnormal_pH_regulation0.84838474
125MP0002429_abnormal_blood_cell0.83824603
126MP0003890_abnormal_embryonic-extraembry0.83630950
127MP0010329_abnormal_lipoprotein_level0.83499900
128MP0002722_abnormal_immune_system0.83165140
129MP0002837_dystrophic_cardiac_calcinosis0.82707782
130MP0008961_abnormal_basal_metabolism0.82048740
131MP0000653_abnormal_sex_gland0.80802109
132MP0001661_extended_life_span0.80379925
133MP0003936_abnormal_reproductive_system0.80018086
134MP0005386_behavior/neurological_phenoty0.79851843
135MP0004924_abnormal_behavior0.79851843
136MP0002733_abnormal_thermal_nociception0.79450449
137MP0000716_abnormal_immune_system0.77140495
138MP0000015_abnormal_ear_pigmentation0.77036831
139MP0001697_abnormal_embryo_size0.76909048
140MP0003121_genomic_imprinting0.76297607
141MP0001853_heart_inflammation0.75931959
142MP0002234_abnormal_pharynx_morphology0.75890534
143MP0003123_paternal_imprinting0.75795513
144MP0001800_abnormal_humoral_immune0.75747101
145MP0001984_abnormal_olfaction0.74965181
146MP0000598_abnormal_liver_morphology0.74963284
147MP0003638_abnormal_response/metabolism_0.74916397
148MP0010386_abnormal_urinary_bladder0.74793600
149MP0008789_abnormal_olfactory_epithelium0.74554616
150MP0005266_abnormal_metabolism0.74429416
151MP0002723_abnormal_immune_serum0.74274932
152MP0005395_other_phenotype0.74159423
153MP0000516_abnormal_urinary_system0.74108400
154MP0005367_renal/urinary_system_phenotyp0.74108400
155MP0002572_abnormal_emotion/affect_behav0.73474186
156MP0002148_abnormal_hypersensitivity_rea0.73416038
157MP0002420_abnormal_adaptive_immunity0.71924103
158MP0005084_abnormal_gallbladder_morpholo0.71470111
159MP0000609_abnormal_liver_physiology0.71024004
160MP0001819_abnormal_immune_cell0.70825187
161MP0004197_abnormal_fetal_growth/weight/0.70562444
162MP0000627_abnormal_mammary_gland0.70349513

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.42987192
2Increased serum pyruvate (HP:0003542)4.33734823
3Abnormality of glycolysis (HP:0004366)4.33734823
4Acute necrotizing encephalopathy (HP:0006965)4.19888380
5Hepatocellular necrosis (HP:0001404)4.12516122
6Abnormal mitochondria in muscle tissue (HP:0008316)3.91223270
7Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.90318371
8Decreased activity of mitochondrial respiratory chain (HP:0008972)3.90318371
9Mitochondrial inheritance (HP:0001427)3.84903279
10Hepatic necrosis (HP:0002605)3.78522284
11Congenital stationary night blindness (HP:0007642)3.76380385
12Increased CSF lactate (HP:0002490)3.70685898
13Cerebral hypomyelination (HP:0006808)3.55249104
14Acute encephalopathy (HP:0006846)3.47498143
15Abnormality of alanine metabolism (HP:0010916)3.31525544
16Hyperalaninemia (HP:0003348)3.31525544
17Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.31525544
18Progressive macrocephaly (HP:0004481)3.26804023
19Hypobetalipoproteinemia (HP:0003563)3.18860643
20Type II lissencephaly (HP:0007260)3.14671980
21Increased serum lactate (HP:0002151)3.13631525
22Cerebral edema (HP:0002181)3.02338491
23Breast hypoplasia (HP:0003187)2.99703086
24Hyperventilation (HP:0002883)2.96584739
25Lactic acidosis (HP:0003128)2.95650382
26Congenital, generalized hypertrichosis (HP:0004540)2.94488422
27Progressive inability to walk (HP:0002505)2.91808647
28Abnormality of the anterior horn cell (HP:0006802)2.80669950
29Degeneration of anterior horn cells (HP:0002398)2.80669950
30Concave nail (HP:0001598)2.80239762
31Oral leukoplakia (HP:0002745)2.79512629
32Large for gestational age (HP:0001520)2.77761152
333-Methylglutaconic aciduria (HP:0003535)2.76531338
34Abnormality of the pons (HP:0007361)2.72674394
35Abnormality of the renal cortex (HP:0011035)2.63912787
36Abnormality of cells of the erythroid lineage (HP:0012130)2.63782183
37Lissencephaly (HP:0001339)2.60372181
38Rough bone trabeculation (HP:0100670)2.60155266
39Nephronophthisis (HP:0000090)2.59687392
40Hypoplasia of the pons (HP:0012110)2.58658409
41CNS demyelination (HP:0007305)2.57662432
42Carpal bone hypoplasia (HP:0001498)2.56235608
43Delusions (HP:0000746)2.54760361
44Aplastic anemia (HP:0001915)2.54366284
45Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.50568267
46Methylmalonic acidemia (HP:0002912)2.50155553
47Inability to walk (HP:0002540)2.49632942
48Abnormality of aromatic amino acid family metabolism (HP:0004338)2.48938723
49Abnormal number of erythroid precursors (HP:0012131)2.44580145
50Abnormality of the heme biosynthetic pathway (HP:0010472)2.43221010
51Irregular epiphyses (HP:0010582)2.42875911
52Tubular atrophy (HP:0000092)2.42588355
53Microvesicular hepatic steatosis (HP:0001414)2.41968687
54Respiratory failure (HP:0002878)2.41323437
55Protruding tongue (HP:0010808)2.41227590
56Lipid accumulation in hepatocytes (HP:0006561)2.38433190
57Increased hepatocellular lipid droplets (HP:0006565)2.35691450
58Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.35010861
59True hermaphroditism (HP:0010459)2.34017952
60Hypothermia (HP:0002045)2.33115224
61Exercise intolerance (HP:0003546)2.31282857
62Poor suck (HP:0002033)2.28156398
63Pendular nystagmus (HP:0012043)2.27700265
64Abnormality of the renal medulla (HP:0100957)2.26577590
65Microretrognathia (HP:0000308)2.25463260
66Lethargy (HP:0001254)2.23901753
67Hypoplasia of the capital femoral epiphysis (HP:0003090)2.22723419
68Atrophy/Degeneration involving motor neurons (HP:0007373)2.21560539
69CNS hypomyelination (HP:0003429)2.21194635
70Hyperglycinemia (HP:0002154)2.20774475
71Pheochromocytoma (HP:0002666)2.20164447
72Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.19599332
73Abnormality of the carotid arteries (HP:0005344)2.19402922
74Emotional lability (HP:0000712)2.18950406
75Abnormal protein glycosylation (HP:0012346)2.18313892
76Abnormal glycosylation (HP:0012345)2.18313892
77Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.18313892
78Abnormal protein N-linked glycosylation (HP:0012347)2.18313892
79Respiratory difficulties (HP:0002880)2.17825377
80Postnatal microcephaly (HP:0005484)2.17367889
81Cerebellar dysplasia (HP:0007033)2.16602851
82Pancreatic fibrosis (HP:0100732)2.11641964
83Renal Fanconi syndrome (HP:0001994)2.08239211
84Brushfield spots (HP:0001088)2.08123394
85Abnormality of pyrimidine metabolism (HP:0004353)2.07022166
86Meningioma (HP:0002858)2.06048527
87Neonatal respiratory distress (HP:0002643)2.02204737
88Neuroendocrine neoplasm (HP:0100634)2.00910870
89Gonadotropin excess (HP:0000837)1.97822638
90Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.97436100
91Absent epiphyses (HP:0010577)1.97436100
92Secondary amenorrhea (HP:0000869)1.97331261
93Unsteady gait (HP:0002317)1.97073071
94Leukodystrophy (HP:0002415)1.96641603
95Type I transferrin isoform profile (HP:0003642)1.96488964
96Attenuation of retinal blood vessels (HP:0007843)1.96406897
97Furrowed tongue (HP:0000221)1.95856618
98Retinal dysplasia (HP:0007973)1.95765872
99Methylmalonic aciduria (HP:0012120)1.95169332
100Abnormality of monocarboxylic acid metabolism (HP:0010996)1.95152416
101Bilateral microphthalmos (HP:0007633)1.95128222
102Poor head control (HP:0002421)1.94696793
103Exertional dyspnea (HP:0002875)1.94343102
104Patellar aplasia (HP:0006443)1.94237519
105Clumsiness (HP:0002312)1.92418350
106Multiple enchondromatosis (HP:0005701)1.92417001
107Sensory axonal neuropathy (HP:0003390)1.89970710
108Abnormality of the labia minora (HP:0012880)1.89589063
109Gout (HP:0001997)1.88577833
110Pancreatic cysts (HP:0001737)1.87698407
111Progressive external ophthalmoplegia (HP:0000590)1.86658358
112Generalized aminoaciduria (HP:0002909)1.86268908
113Severe muscular hypotonia (HP:0006829)1.86123457
114Abnormal hair whorl (HP:0010721)1.85856037
115Increased intramyocellular lipid droplets (HP:0012240)1.85809219
116Genetic anticipation (HP:0003743)1.84744077
117Ketoacidosis (HP:0001993)1.84293032
118Aplasia/Hypoplasia of the uvula (HP:0010293)1.84093039
119Chronic hepatic failure (HP:0100626)1.83821360
120Abnormal trabecular bone morphology (HP:0100671)1.83758406
121Conjunctival hamartoma (HP:0100780)1.83471622
122Aplasia/Hypoplasia of the patella (HP:0006498)1.82693670
123Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.82629713
124Renal cortical cysts (HP:0000803)1.82576086
125Abnormality of serum amino acid levels (HP:0003112)1.82249342
126Aplasia/hypoplasia of the uterus (HP:0008684)1.82228851
127Fair hair (HP:0002286)1.81943961
128Macrocytic anemia (HP:0001972)1.81891005
129Reduced antithrombin III activity (HP:0001976)1.81789666
130IgG deficiency (HP:0004315)1.81635234
131Self-mutilation (HP:0000742)1.81595657
132Autoamputation (HP:0001218)1.81138302
133Thrombocytosis (HP:0001894)1.80083560
134Abnormality of methionine metabolism (HP:0010901)1.78417343
135Prolonged partial thromboplastin time (HP:0003645)1.78355111
136Megaloblastic anemia (HP:0001889)1.77992096
137Cystic liver disease (HP:0006706)1.77456781
138Absent thumb (HP:0009777)1.77339155
139Optic disc pallor (HP:0000543)1.76523099
140Gliosis (HP:0002171)1.76411166
141Tongue fasciculations (HP:0001308)1.76391881
142Abnormal spermatogenesis (HP:0008669)1.75873185
143Abnormality of midbrain morphology (HP:0002418)1.75559113
144Molar tooth sign on MRI (HP:0002419)1.75559113
145Abnormal pupillary function (HP:0007686)1.75253745
146Type 2 muscle fiber atrophy (HP:0003554)1.74903795
147Medial flaring of the eyebrow (HP:0010747)1.74416907
148Prostate neoplasm (HP:0100787)1.73402723
149Dysautonomia (HP:0002459)1.73208232
150Pachygyria (HP:0001302)1.71923770
151Testicular atrophy (HP:0000029)1.71171160
152Opisthotonus (HP:0002179)1.70729281
153Small hand (HP:0200055)1.70268787
154Elfin facies (HP:0004428)1.70025541
155Chorioretinal atrophy (HP:0000533)1.69679921
156Breast carcinoma (HP:0003002)1.69673511
157Premature ovarian failure (HP:0008209)1.69471360
158Increased muscle lipid content (HP:0009058)1.68351805
159Death in infancy (HP:0001522)1.67949455
160Decreased electroretinogram (ERG) amplitude (HP:0000654)1.67634474
161Stomach cancer (HP:0012126)1.67568249
162Progressive microcephaly (HP:0000253)1.66947591
163Abnormality of homocysteine metabolism (HP:0010919)1.66913719
164Homocystinuria (HP:0002156)1.66913719
165Septate vagina (HP:0001153)1.66898448

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.43446649
2EIF2AK13.68933058
3STK163.68063733
4WEE13.14389660
5FRK3.11294556
6VRK23.08528328
7TSSK63.05976067
8GRK13.03661258
9NME22.60910017
10CCNB12.41940312
11TAOK32.34999999
12EIF2AK32.28777237
13NME12.26005942
14MAPKAPK32.16466234
15BRSK22.08775366
16TAF12.05199769
17NUAK12.04353245
18ARAF2.01099882
19TESK21.96890289
20TESK11.93451851
21MAP3K121.91455365
22CDC71.87411777
23WNK41.86406176
24PLK41.86003195
25MAP3K41.81744541
26VRK11.80297797
27PIM21.79577443
28SRPK11.74313957
29ACVR1B1.73488155
30BRSK11.68087519
31LIMK11.66018288
32TRIM281.65414458
33PDK31.63487868
34PDK41.63487868
35SIK31.63313331
36BRAF1.56568586
37NEK11.54138701
38SIK21.49677217
39AKT31.49417414
40PLK31.36451784
41WNK31.35043378
42MAPK131.27753472
43KDR1.27543377
44ERBB31.25779266
45MKNK11.24809808
46BCR1.22976286
47DYRK21.21925060
48AURKA1.20911779
49CHUK1.20843035
50NEK21.18793701
51CSNK1A1L1.16225949
52PLK11.11892146
53PHKG11.11309412
54PHKG21.11309412
55TGFBR11.09332585
56EPHA31.08914611
57DAPK11.08855857
58CASK1.08429528
59CAMKK21.08245969
60IRAK11.06280378
61PIK3CA0.96672783
62BCKDK0.94051427
63INSRR0.93274956
64MAP4K20.93211504
65PLK20.92967814
66GRK60.92310833
67IRAK30.91634562
68ZAP700.88436301
69BMPR1B0.86533742
70GRK50.84028356
71PDK20.83166706
72MARK10.83143792
73MAP2K20.82954745
74EIF2AK20.80913856
75STK390.78791797
76IKBKB0.77257194
77CSNK1G10.74216379
78AURKB0.72882616
79TXK0.71348604
80CSNK2A10.70974298
81PRKCI0.70809335
82RPS6KA50.70658372
83SIK10.70108623
84ZAK0.69794028
85OXSR10.69131568
86ABL20.68856459
87PBK0.67977398
88MAP2K70.67024683
89MAP3K140.66638481
90CLK10.66633798
91CSNK2A20.65670985
92PRKCE0.65016739
93ATR0.64307946
94SYK0.61970791
95TTK0.59374865
96MYLK0.58778530
97MINK10.58496021
98CSNK1G30.55714537
99PAK10.55661016
100CSNK1G20.54871687
101MAP4K10.54256406
102PAK30.54119680
103PRKCG0.53841303
104CDK80.53719301
105TLK10.53352554
106EPHA20.53168804
107ERBB40.53038858
108MAP3K50.52624164
109MAP3K110.52141133
110DYRK30.50541169
111PNCK0.49967384
112PASK0.47222196
113MAP2K60.46086566
114CHEK10.45521047
115CHEK20.45256646
116BMPR20.45095080
117MAP2K40.45038878
118ADRBK20.44261014
119DAPK20.42555017
120CDK190.42540707
121PIM10.42363473
122BLK0.40882415
123IRAK40.39733400
124PINK10.39593900
125MKNK20.39183470
126MAP2K10.37672462
127ADRBK10.37398861
128MAPK40.34873213
129MAPK150.34725254
130CSNK1E0.34673942
131TRIB30.34564073
132CDK30.34161786
133TRPM70.33682373
134TYK20.32772556
135RPS6KA40.32706306
136CDK70.32078783
137DAPK30.30948185
138MAP3K80.30519470
139LYN0.30456053
140YES10.30185719
141HIPK20.30159301
142MST40.29949070
143CDK10.29629318
144CSNK1D0.29150881
145CDK180.28963215
146PRKCD0.27913830
147NEK90.27789443
148MARK30.27661613
149RPS6KB20.27125822

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030505.79344943
2RNA polymerase_Homo sapiens_hsa030203.93722242
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.98750922
4Ribosome_Homo sapiens_hsa030102.81684663
5DNA replication_Homo sapiens_hsa030302.66830986
6Oxidative phosphorylation_Homo sapiens_hsa001902.65452994
7Pyrimidine metabolism_Homo sapiens_hsa002402.59606873
8Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.56831986
9Parkinsons disease_Homo sapiens_hsa050122.43395541
10Mismatch repair_Homo sapiens_hsa034302.19401745
11Protein export_Homo sapiens_hsa030602.13766916
12RNA transport_Homo sapiens_hsa030132.13126813
13Spliceosome_Homo sapiens_hsa030402.12573151
14Nucleotide excision repair_Homo sapiens_hsa034202.05681866
15Huntingtons disease_Homo sapiens_hsa050161.93376997
16Base excision repair_Homo sapiens_hsa034101.88463636
17Vitamin B6 metabolism_Homo sapiens_hsa007501.88038427
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.84783552
19Phototransduction_Homo sapiens_hsa047441.82062394
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.81444177
21Basal transcription factors_Homo sapiens_hsa030221.66262558
22Drug metabolism - other enzymes_Homo sapiens_hsa009831.65822957
23Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.62573993
24Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.61539586
25Cysteine and methionine metabolism_Homo sapiens_hsa002701.60683667
26Homologous recombination_Homo sapiens_hsa034401.58980150
27Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.51690148
28Purine metabolism_Homo sapiens_hsa002301.50640886
29Alzheimers disease_Homo sapiens_hsa050101.43848541
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.42071718
31Maturity onset diabetes of the young_Homo sapiens_hsa049501.38353989
32Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.37976626
33Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.34734384
34Regulation of autophagy_Homo sapiens_hsa041401.33213831
35Pentose phosphate pathway_Homo sapiens_hsa000301.32502880
36Folate biosynthesis_Homo sapiens_hsa007901.27585937
37Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26735025
38One carbon pool by folate_Homo sapiens_hsa006701.23336292
39Biosynthesis of amino acids_Homo sapiens_hsa012301.22672250
40Pyruvate metabolism_Homo sapiens_hsa006201.21982338
41Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21764740
42Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21727666
43Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.21257166
44Cell cycle_Homo sapiens_hsa041101.20140675
452-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.14911441
46Carbon metabolism_Homo sapiens_hsa012001.12430140
47RNA degradation_Homo sapiens_hsa030181.11034057
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.06834848
49Epstein-Barr virus infection_Homo sapiens_hsa051691.06312051
50Non-homologous end-joining_Homo sapiens_hsa034501.06001357
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.05514155
52Nitrogen metabolism_Homo sapiens_hsa009101.05372641
53Primary bile acid biosynthesis_Homo sapiens_hsa001201.02541829
54Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.02391999
55Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.00152238
56Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.99247362
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.97712560
58Circadian rhythm_Homo sapiens_hsa047100.97590429
59Phenylalanine metabolism_Homo sapiens_hsa003600.94753591
60Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.93727688
61Collecting duct acid secretion_Homo sapiens_hsa049660.89888036
62Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.89856630
63Fanconi anemia pathway_Homo sapiens_hsa034600.86401591
64Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85954603
65Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.85667971
66Selenocompound metabolism_Homo sapiens_hsa004500.83744670
67Linoleic acid metabolism_Homo sapiens_hsa005910.83140794
68alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81936688
69Fructose and mannose metabolism_Homo sapiens_hsa000510.81655064
70Glutathione metabolism_Homo sapiens_hsa004800.81279279
71Metabolic pathways_Homo sapiens_hsa011000.77455544
72Caffeine metabolism_Homo sapiens_hsa002320.77039273
73Antigen processing and presentation_Homo sapiens_hsa046120.75270529
74Steroid hormone biosynthesis_Homo sapiens_hsa001400.74956803
75Peroxisome_Homo sapiens_hsa041460.73134189
76Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.71022598
77Tyrosine metabolism_Homo sapiens_hsa003500.69249814
78Nicotine addiction_Homo sapiens_hsa050330.69115742
79Sulfur metabolism_Homo sapiens_hsa009200.68569514
80Steroid biosynthesis_Homo sapiens_hsa001000.64212786
81Fatty acid elongation_Homo sapiens_hsa000620.59329282
82Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.55043143
83Vibrio cholerae infection_Homo sapiens_hsa051100.52771138
84Galactose metabolism_Homo sapiens_hsa000520.50914930
85mRNA surveillance pathway_Homo sapiens_hsa030150.50791997
86Tryptophan metabolism_Homo sapiens_hsa003800.50649049
87Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.49475156
88Sulfur relay system_Homo sapiens_hsa041220.47992490
89Propanoate metabolism_Homo sapiens_hsa006400.47192085
90Ether lipid metabolism_Homo sapiens_hsa005650.45734487
91Synaptic vesicle cycle_Homo sapiens_hsa047210.44760762
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.44254573
93p53 signaling pathway_Homo sapiens_hsa041150.43286463
94Retinol metabolism_Homo sapiens_hsa008300.43226222
95Pentose and glucuronate interconversions_Homo sapiens_hsa000400.43056619
96Oocyte meiosis_Homo sapiens_hsa041140.41369437
97Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.40944464
98Cardiac muscle contraction_Homo sapiens_hsa042600.40032161
99Taste transduction_Homo sapiens_hsa047420.40009467
100Phagosome_Homo sapiens_hsa041450.38748783
101Chemical carcinogenesis_Homo sapiens_hsa052040.37227629
102Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.36157650
103Allograft rejection_Homo sapiens_hsa053300.36099915
104Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.36029956
105Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.35817948
106Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.34499515
107Mineral absorption_Homo sapiens_hsa049780.34164998
108Butanoate metabolism_Homo sapiens_hsa006500.33994439
109beta-Alanine metabolism_Homo sapiens_hsa004100.31622655
110Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.31360623
111Legionellosis_Homo sapiens_hsa051340.31298651
112Histidine metabolism_Homo sapiens_hsa003400.29362493
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.29196787
114Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.27985990
115Systemic lupus erythematosus_Homo sapiens_hsa053220.26821366
116N-Glycan biosynthesis_Homo sapiens_hsa005100.26741551
117Primary immunodeficiency_Homo sapiens_hsa053400.23301510
118Lysine degradation_Homo sapiens_hsa003100.22975842
119ABC transporters_Homo sapiens_hsa020100.22372232
120Arginine and proline metabolism_Homo sapiens_hsa003300.21449461
121Morphine addiction_Homo sapiens_hsa050320.21421430
122Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.20414223
123Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.20017636
124Viral carcinogenesis_Homo sapiens_hsa052030.18920794
125Fatty acid biosynthesis_Homo sapiens_hsa000610.17067410
126Intestinal immune network for IgA production_Homo sapiens_hsa046720.15980661
127Sphingolipid metabolism_Homo sapiens_hsa006000.14946095
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.12068770
129Serotonergic synapse_Homo sapiens_hsa047260.11927369
130Dopaminergic synapse_Homo sapiens_hsa047280.11489688

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