CREB1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.94275692
2pyrimidine nucleobase catabolic process (GO:0006208)4.65718044
3mitotic sister chromatid cohesion (GO:0007064)4.38357903
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.22617292
5presynaptic membrane organization (GO:0097090)4.01138466
6regulation of DNA endoreduplication (GO:0032875)3.86428825
7olfactory bulb development (GO:0021772)3.83337589
8DNA double-strand break processing (GO:0000729)3.72212133
9positive regulation of gamma-delta T cell activation (GO:0046645)3.65761770
10establishment of protein localization to Golgi (GO:0072600)3.46956978
11nuclear pore complex assembly (GO:0051292)3.43329478
12nucleobase catabolic process (GO:0046113)3.39778334
13tachykinin receptor signaling pathway (GO:0007217)3.36003628
14protein targeting to Golgi (GO:0000042)3.33325121
15activated T cell proliferation (GO:0050798)3.32265803
16monoubiquitinated protein deubiquitination (GO:0035520)3.28814845
17centriole replication (GO:0007099)3.25302523
18antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.23762162
19definitive hemopoiesis (GO:0060216)3.21491390
20DNA topological change (GO:0006265)3.18985409
21DNA unwinding involved in DNA replication (GO:0006268)3.18158437
22regulation of RNA export from nucleus (GO:0046831)3.13997055
23limb bud formation (GO:0060174)3.13553093
24microtubule anchoring (GO:0034453)3.12426908
25V(D)J recombination (GO:0033151)3.11840587
26negative regulation of cell killing (GO:0031342)3.09169412
27negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.09169412
28nuclear pore organization (GO:0006999)3.07280279
29hepatocyte apoptotic process (GO:0097284)3.04760364
30negative T cell selection (GO:0043383)3.02019782
31retrograde transport, vesicle recycling within Golgi (GO:0000301)3.01401264
32positive T cell selection (GO:0043368)3.00337963
33alternative mRNA splicing, via spliceosome (GO:0000380)2.97578434
34epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.95445244
35histone H3-K4 trimethylation (GO:0080182)2.94056741
36glucocorticoid receptor signaling pathway (GO:0042921)2.93386574
37neuron cell-cell adhesion (GO:0007158)2.88516036
38negative thymic T cell selection (GO:0045060)2.86098569
39forebrain neuron differentiation (GO:0021879)2.84040651
40negative regulation of DNA recombination (GO:0045910)2.82830689
41central nervous system projection neuron axonogenesis (GO:0021952)2.82567149
42regulation of histone H3-K9 methylation (GO:0051570)2.82464178
43cytoplasmic mRNA processing body assembly (GO:0033962)2.82130724
44protein K11-linked deubiquitination (GO:0035871)2.81394895
45mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.79428229
46positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.79428229
47negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.79268964
48intraciliary transport (GO:0042073)2.78639174
49mitotic chromosome condensation (GO:0007076)2.77997749
50corticosteroid receptor signaling pathway (GO:0031958)2.77370447
51negative regulation of histone methylation (GO:0031061)2.77329206
52behavioral response to nicotine (GO:0035095)2.75605033
53histone H3-K36 demethylation (GO:0070544)2.75104167
54retinal ganglion cell axon guidance (GO:0031290)2.73694055
55regulation of sister chromatid cohesion (GO:0007063)2.72390832
56neural tube formation (GO:0001841)2.71521374
57regulation of gamma-delta T cell differentiation (GO:0045586)2.70896524
58positive thymic T cell selection (GO:0045059)2.70799341
59mRNA splice site selection (GO:0006376)2.70642078
60peptidyl-lysine trimethylation (GO:0018023)2.69352853
61positive regulation of mRNA processing (GO:0050685)2.68478094
62regulation of B cell receptor signaling pathway (GO:0050855)2.67999501
63cilium morphogenesis (GO:0060271)2.66502454
64cerebral cortex radially oriented cell migration (GO:0021799)2.65339555
65pore complex assembly (GO:0046931)2.64473890
66T cell selection (GO:0045058)2.63764600
67regulation of gene silencing by RNA (GO:0060966)2.63626483
68regulation of posttranscriptional gene silencing (GO:0060147)2.63626483
69regulation of gene silencing by miRNA (GO:0060964)2.63626483
70central nervous system neuron axonogenesis (GO:0021955)2.62038005
71RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.61726200
72B cell homeostasis (GO:0001782)2.61583533
73phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.61504795
74negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.61359514
75negative regulation of translation, ncRNA-mediated (GO:0040033)2.61359514
76regulation of translation, ncRNA-mediated (GO:0045974)2.61359514
77fucose catabolic process (GO:0019317)2.61253354
78L-fucose metabolic process (GO:0042354)2.61253354
79L-fucose catabolic process (GO:0042355)2.61253354
80positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.60704224
81antigen processing and presentation of endogenous antigen (GO:0019883)2.59286429
82regulation of nucleobase-containing compound transport (GO:0032239)2.58852034
83regulation of interleukin-12 biosynthetic process (GO:0045075)2.58218523
84photoreceptor cell maintenance (GO:0045494)2.57984700
85regulation of telomere maintenance (GO:0032204)2.57424522
86regulation of gamma-delta T cell activation (GO:0046643)2.56785182
87antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.55998366
88antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.55998366
89negative regulation of DNA-dependent DNA replication (GO:2000104)2.55955210
90positive regulation of mRNA 3-end processing (GO:0031442)2.55015211
91regulation of non-canonical Wnt signaling pathway (GO:2000050)2.54887771
92replication fork processing (GO:0031297)2.54584169
93regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.54194190
94negative regulation of fibroblast apoptotic process (GO:2000270)2.53314137
95head development (GO:0060322)2.52972579
96DNA demethylation (GO:0080111)2.52660225
97regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.52548571
98positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.52548571
99positive regulation of mRNA catabolic process (GO:0061014)2.52458291
100negative regulation of phagocytosis (GO:0050765)2.50743413
101histone H4-K16 acetylation (GO:0043984)2.48712559
102somite development (GO:0061053)2.48033199
103pre-miRNA processing (GO:0031054)2.47820896
104protein localization to kinetochore (GO:0034501)2.47330486
105kinetochore organization (GO:0051383)2.46341279
106microtubule depolymerization (GO:0007019)2.45424132
107postsynaptic membrane organization (GO:0001941)2.45422595
108sister chromatid segregation (GO:0000819)2.44611347
109positive regulation of oligodendrocyte differentiation (GO:0048714)2.43225889
110regulation of histone H3-K4 methylation (GO:0051569)2.42822841
111DNA geometric change (GO:0032392)2.42719644
112histone H3-K9 methylation (GO:0051567)2.42474280
113radial glial cell differentiation (GO:0060019)2.42319271
114histone H3-K4 methylation (GO:0051568)2.42276685
115T cell homeostasis (GO:0043029)2.41998739
116positive regulation of B cell differentiation (GO:0045579)2.41937005
117establishment of nucleus localization (GO:0040023)2.41380920
118DNA duplex unwinding (GO:0032508)2.40890360
119histone H2A acetylation (GO:0043968)2.40367121
120nonmotile primary cilium assembly (GO:0035058)2.40179635
121protein localization to Golgi apparatus (GO:0034067)2.39565981
122histone H3-K9 modification (GO:0061647)2.39521155
123kidney morphogenesis (GO:0060993)2.39385024
124neuron fate determination (GO:0048664)2.39114306
125regulation of mRNA 3-end processing (GO:0031440)2.39000448
126epithelial cilium movement (GO:0003351)2.38956972
127B cell receptor signaling pathway (GO:0050853)2.38376831
128tongue development (GO:0043586)2.38298719
129response to pheromone (GO:0019236)2.38173502
130regulation of fibroblast apoptotic process (GO:2000269)2.38173155
131regulation of chromatin silencing (GO:0031935)2.38035992
132cilium organization (GO:0044782)2.37634053
133negative regulation of RNA splicing (GO:0033119)2.37455353
134positive regulation of mRNA metabolic process (GO:1903313)2.37452229
135cilium assembly (GO:0042384)2.37347943
136embryonic hemopoiesis (GO:0035162)2.36656964
137RNA stabilization (GO:0043489)2.36614953
138mRNA stabilization (GO:0048255)2.36614953
139positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.36042429
140positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.36042429
141positive regulation of mitotic sister chromatid separation (GO:1901970)2.36042429
142protein localization to cilium (GO:0061512)2.35791646
143resolution of meiotic recombination intermediates (GO:0000712)2.35591653
144limb development (GO:0060173)2.34536585
145appendage development (GO:0048736)2.34536585
146negative regulation of B cell proliferation (GO:0030889)2.34530546
147regulation of collateral sprouting (GO:0048670)2.33765158
148regulation of B cell differentiation (GO:0045577)2.32894106
149dosage compensation (GO:0007549)2.32799439
150cilium or flagellum-dependent cell motility (GO:0001539)2.32285373
151positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.31649550
152DNA integration (GO:0015074)2.31434275
153cerebral cortex cell migration (GO:0021795)2.30839310
154T cell differentiation (GO:0030217)2.30796184
155positive regulation of histone H3-K4 methylation (GO:0051571)2.30717154
156interkinetic nuclear migration (GO:0022027)2.30677565
157regulation of mRNA catabolic process (GO:0061013)2.29902558
158histone mRNA catabolic process (GO:0071044)2.29430171
159regulation of histone methylation (GO:0031060)2.29167266
160thymic T cell selection (GO:0045061)2.29100911
161lymphocyte homeostasis (GO:0002260)2.28416843
162histone H3-K9 demethylation (GO:0033169)2.27868786
163translesion synthesis (GO:0019985)2.27074905
164alpha-beta T cell activation (GO:0046631)2.26814896
165regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.22400260
166positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.22400260
167sister chromatid cohesion (GO:0007062)2.22281855
168leukocyte aggregation (GO:0070486)2.22273995
169interferon-gamma production (GO:0032609)2.21935368
170regulation of mRNA stability (GO:0043488)2.21859544
171peptidyl-lysine methylation (GO:0018022)2.21544174
172germ cell migration (GO:0008354)2.16839130
173alpha-beta T cell differentiation (GO:0046632)2.16036460
174histone lysine demethylation (GO:0070076)2.16034267
175protein localization to chromosome, centromeric region (GO:0071459)2.14705094

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.14621332
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse5.24844394
3FOXM1_23109430_ChIP-Seq_U2OS_Human4.23527705
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.99375265
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.92960252
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.67987718
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.15258315
8GBX2_23144817_ChIP-Seq_PC3_Human2.81820247
9HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.69979878
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.67685002
11GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.65403396
12* STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.63170104
13* TAF15_26573619_Chip-Seq_HEK293_Human2.62801306
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.61441544
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.58590515
16ZNF274_21170338_ChIP-Seq_K562_Hela2.56840048
17MYC_22102868_ChIP-Seq_BL_Human2.44834628
18* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42715754
19CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.22746297
20SALL1_21062744_ChIP-ChIP_HESCs_Human2.21897864
21* P300_19829295_ChIP-Seq_ESCs_Human2.20906814
22* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.20874432
23TP63_19390658_ChIP-ChIP_HaCaT_Human2.20774420
24IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.18254602
25BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.17603276
26KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.17197109
27RUNX_20019798_ChIP-Seq_JUKART_Human2.10814019
28MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.07010479
29GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.03868704
30VDR_22108803_ChIP-Seq_LS180_Human2.02940920
31AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human2.02265679
32* FLI1_27457419_Chip-Seq_LIVER_Mouse1.99882721
33SMAD_19615063_ChIP-ChIP_OVARY_Human1.97494169
34CTBP2_25329375_ChIP-Seq_LNCAP_Human1.94156947
35* MYB_26560356_Chip-Seq_TH2_Human1.88566218
36SCL_19346495_ChIP-Seq_HPC-7_Human1.87362837
37MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.84523423
38OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.84361297
39EZH2_22144423_ChIP-Seq_EOC_Human1.83998684
40PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.83322164
41ER_23166858_ChIP-Seq_MCF-7_Human1.83136991
42CTBP1_25329375_ChIP-Seq_LNCAP_Human1.80549286
43ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.80431149
44* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.80294430
45RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.79999999
46* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.79364229
47E2F1_21310950_ChIP-Seq_MCF-7_Human1.77928173
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.74218065
49* SMAD4_21799915_ChIP-Seq_A2780_Human1.71116063
50UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.68554316
51ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.67893910
52SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.61917794
53* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.61827291
54CIITA_25753668_ChIP-Seq_RAJI_Human1.61793174
55TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.61297276
56* MYB_26560356_Chip-Seq_TH1_Human1.60587306
57AR_21572438_ChIP-Seq_LNCaP_Human1.60334604
58PIAS1_25552417_ChIP-Seq_VCAP_Human1.58003119
59IRF8_21731497_ChIP-ChIP_J774_Mouse1.57725038
60IRF8_27001747_Chip-Seq_BMDM_Mouse1.55705390
61* SMAD3_21741376_ChIP-Seq_EPCs_Human1.55620241
62* STAT3_23295773_ChIP-Seq_U87_Human1.51847569
63* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.51489703
64* EZH2_27294783_Chip-Seq_NPCs_Mouse1.51091540
65NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50400971
66MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49886780
67* NANOG_18555785_Chip-Seq_ESCs_Mouse1.49866716
68MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.49203234
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.48846169
70* TCF7_22412390_ChIP-Seq_EML_Mouse1.48496490
71* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.48030769
72* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.47614448
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.45674693
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.44767904
75CBP_20019798_ChIP-Seq_JUKART_Human1.44767904
76* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.44762570
77VDR_21846776_ChIP-Seq_THP-1_Human1.43957903
78BCAT_22108803_ChIP-Seq_LS180_Human1.43783514
79* STAT4_19710469_ChIP-ChIP_TH1__Mouse1.43379500
80WT1_19549856_ChIP-ChIP_CCG9911_Human1.42009538
81VDR_24763502_ChIP-Seq_THP-1_Human1.38510897
82FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.37432749
83STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36212635
84* AR_25329375_ChIP-Seq_VCAP_Human1.35431809
85PKCTHETA_26484144_Chip-Seq_BREAST_Human1.35151049
86MAF_26560356_Chip-Seq_TH1_Human1.34939479
87* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.34707412
88TCF4_23295773_ChIP-Seq_U87_Human1.34249690
89KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.33386829
90* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.32596181
91* EWS_26573619_Chip-Seq_HEK293_Human1.31868445
92RUNX2_22187159_ChIP-Seq_PCA_Human1.31837708
93ELK1_19687146_ChIP-ChIP_HELA_Human1.31471435
94UTX_26944678_Chip-Seq_JUKART_Human1.30997204
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28075620
96* NFE2_27457419_Chip-Seq_LIVER_Mouse1.26549839
97VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25748756
98FUS_26573619_Chip-Seq_HEK293_Human1.25121711
99POU3F2_20337985_ChIP-ChIP_501MEL_Human1.23897599
100NR3C1_21868756_ChIP-Seq_MCF10A_Human1.23819254
101* P53_22387025_ChIP-Seq_ESCs_Mouse1.23126251
102* E2F1_18555785_Chip-Seq_ESCs_Mouse1.23017792
103MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.21638410
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.21375109
105TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.21006141
106* GATA3_27048872_Chip-Seq_THYMUS_Human1.18859910
107* CMYC_18555785_Chip-Seq_ESCs_Mouse1.18470395
108PRDM14_20953172_ChIP-Seq_ESCs_Human1.17877696
109IRF1_19129219_ChIP-ChIP_H3396_Human1.16767250
110* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15617880
111* SPI1_23547873_ChIP-Seq_NB4_Human1.14899235
112CDX2_19796622_ChIP-Seq_MESCs_Mouse1.14888202
113* PU_27001747_Chip-Seq_BMDM_Mouse1.13486883
114TCF4_22108803_ChIP-Seq_LS180_Human1.12785228
115KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12030150
116HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.11717514
117YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11167781
118* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.11136193
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.10574512
120NOTCH1_21737748_ChIP-Seq_TLL_Human1.09838639
121DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.08438283
122TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07922669
123* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.06810767
124* P300_18555785_Chip-Seq_ESCs_Mouse1.06567517
125TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05267055
126RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.05217487
127* CRX_20693478_ChIP-Seq_RETINA_Mouse1.05019127
128STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.04887164
129GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.03777071
130TAL1_26923725_Chip-Seq_HPCs_Mouse1.03542396
131RNF2_27304074_Chip-Seq_NSC_Mouse1.03464905
132SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.02360478
133* TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.01982899
134* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.01706041
135KDM2B_26808549_Chip-Seq_REH_Human1.01586019
136STAT6_21828071_ChIP-Seq_BEAS2B_Human1.01460717
137GATA1_22025678_ChIP-Seq_K562_Human1.00789999
138LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00500705
139SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.99895438
140HOXB4_20404135_ChIP-ChIP_EML_Mouse0.98755735
141SPI1_23127762_ChIP-Seq_K562_Human0.98520765
142TCF4_18268006_ChIP-ChIP_LS174T_Human0.97540387
143* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.96951251
144VDR_24787735_ChIP-Seq_THP-1_Human0.95923773
145NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95616427
146PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.93625496
147* GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.91518301
148AR_21909140_ChIP-Seq_LNCAP_Human0.91040123
149NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90931481
150KDM2B_26808549_Chip-Seq_JURKAT_Human0.89586412
151* RUNX1_22412390_ChIP-Seq_EML_Mouse0.89102701
152* KDM2B_26808549_Chip-Seq_DND41_Human0.88942348
153EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.88853088
154* BRD4_25478319_ChIP-Seq_HGPS_Human0.86346407
155PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85785244
156ELF1_17652178_ChIP-ChIP_JURKAT_Human0.84604450
157IGF1R_20145208_ChIP-Seq_DFB_Human0.82992621
158PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81591700
159SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.81281749
160POU5F1_16153702_ChIP-ChIP_HESCs_Human0.81075127
161SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.79856503
162ZNF217_24962896_ChIP-Seq_MCF-7_Human0.79605637
163* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.78262543
164* KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.77739197
165SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.77240600
166FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.76841944
167* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.76513535
168* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.71155820
169* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.71155820
170TP53_16413492_ChIP-PET_HCT116_Human0.70972799
171TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.70880672
172POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.70801229
173TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.70801229

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.65176547
2MP0002166_altered_tumor_susceptibility2.71180670
3MP0002009_preneoplasia2.67955771
4MP0002396_abnormal_hematopoietic_system2.42381645
5MP0006292_abnormal_olfactory_placode2.29110278
6MP0001835_abnormal_antigen_presentation2.28290983
7MP0003880_abnormal_central_pattern2.25634057
8MP0002102_abnormal_ear_morphology2.20340046
9MP0003122_maternal_imprinting2.18762823
10MP0006072_abnormal_retinal_apoptosis2.16891660
11MP0003300_gastrointestinal_ulcer2.16096856
12MP0003763_abnormal_thymus_physiology2.15543116
13MP0002006_tumorigenesis2.14024864
14MP0004808_abnormal_hematopoietic_stem2.13481028
15MP0003787_abnormal_imprinting2.07744548
16MP0008057_abnormal_DNA_replication2.04538960
17MP0010352_gastrointestinal_tract_polyps2.02341534
18MP0005671_abnormal_response_to2.00436650
19MP0010094_abnormal_chromosome_stability1.97993273
20MP0005076_abnormal_cell_differentiation1.97937556
21MP0003724_increased_susceptibility_to1.97341847
22MP0001188_hyperpigmentation1.94368390
23MP0000778_abnormal_nervous_system1.90786699
24MP0006054_spinal_hemorrhage1.86246471
25MP0000427_abnormal_hair_cycle1.81374965
26MP0001800_abnormal_humoral_immune1.80431005
27MP0005253_abnormal_eye_physiology1.79723188
28MP0003121_genomic_imprinting1.78025377
29MP0005499_abnormal_olfactory_system1.76167150
30MP0005394_taste/olfaction_phenotype1.76167150
31MP0003567_abnormal_fetal_cardiomyocyte1.74125377
32MP0005174_abnormal_tail_pigmentation1.73496849
33MP0003221_abnormal_cardiomyocyte_apopto1.71416709
34MP0009278_abnormal_bone_marrow1.68954258
35MP0001529_abnormal_vocalization1.68467066
36MP0002398_abnormal_bone_marrow1.66540419
37MP0003303_peritoneal_inflammation1.66252291
38MP0000703_abnormal_thymus_morphology1.62850437
39MP0000685_abnormal_immune_system1.60004794
40MP0001879_abnormal_lymphatic_vessel1.58752244
41MP0003077_abnormal_cell_cycle1.57371621
42MP0000383_abnormal_hair_follicle1.56376161
43MP0002452_abnormal_antigen_presenting1.55507149
44MP0001790_abnormal_immune_system1.55482052
45MP0005387_immune_system_phenotype1.55482052
46MP0002420_abnormal_adaptive_immunity1.53575975
47MP0010307_abnormal_tumor_latency1.52295851
48MP0001984_abnormal_olfaction1.52071187
49MP0001819_abnormal_immune_cell1.50817391
50MP0003111_abnormal_nucleus_morphology1.49569659
51MP0005187_abnormal_penis_morphology1.46318719
52MP0008058_abnormal_DNA_repair1.42569803
53MP0002233_abnormal_nose_morphology1.42299208
54MP0000465_gastrointestinal_hemorrhage1.40833721
55MP0008007_abnormal_cellular_replicative1.39831269
56MP0010678_abnormal_skin_adnexa1.38341667
57MP0002095_abnormal_skin_pigmentation1.36673756
58MP0005000_abnormal_immune_tolerance1.35747855
59* MP0002723_abnormal_immune_serum1.35710131
60MP0000716_abnormal_immune_system1.35256547
61MP0000537_abnormal_urethra_morphology1.34011084
62MP0000631_abnormal_neuroendocrine_gland1.29828575
63MP0003890_abnormal_embryonic-extraembry1.29585056
64* MP0002751_abnormal_autonomic_nervous1.26588212
65MP0002736_abnormal_nociception_after1.25483541
66MP0010234_abnormal_vibrissa_follicle1.23800835
67MP0002722_abnormal_immune_system1.22759611
68MP0000015_abnormal_ear_pigmentation1.20950170
69MP0001486_abnormal_startle_reflex1.20494665
70MP0000647_abnormal_sebaceous_gland1.19893185
71MP0001968_abnormal_touch/_nociception1.14314476
72MP0003183_abnormal_peptide_metabolism1.14030580
73MP0005391_vision/eye_phenotype1.13574151
74MP0001545_abnormal_hematopoietic_system1.13421826
75MP0005397_hematopoietic_system_phenotyp1.13421826
76MP0002928_abnormal_bile_duct1.12709166
77MP0000350_abnormal_cell_proliferation1.11163528
78MP0005409_darkened_coat_color1.11019399
79MP0002429_abnormal_blood_cell1.10134156
80MP0000689_abnormal_spleen_morphology1.09709026
81MP0005025_abnormal_response_to1.09697900
82MP0005551_abnormal_eye_electrophysiolog1.08132060
83MP0002405_respiratory_system_inflammati1.06816085
84MP0010155_abnormal_intestine_physiology1.05506640
85MP0000049_abnormal_middle_ear1.04833696
86MP0003943_abnormal_hepatobiliary_system1.04617263
87MP0002419_abnormal_innate_immunity1.03776720
88MP0003123_paternal_imprinting1.03700178
89MP0009053_abnormal_anal_canal1.02798348
90MP0004885_abnormal_endolymph1.02787392
91MP0004484_altered_response_of1.02385332
92MP0002877_abnormal_melanocyte_morpholog1.00719156
93MP0004142_abnormal_muscle_tone0.99215542
94MP0000490_abnormal_crypts_of0.97150986
95MP0003755_abnormal_palate_morphology0.97080785
96MP0002148_abnormal_hypersensitivity_rea0.96851793
97MP0004742_abnormal_vestibular_system0.96714768
98MP0001986_abnormal_taste_sensitivity0.95971980
99MP0009703_decreased_birth_body0.94644234
100MP0000428_abnormal_craniofacial_morphol0.94068482
101MP0003866_abnormal_defecation0.93576931
102MP0001853_heart_inflammation0.93146839
103MP0004197_abnormal_fetal_growth/weight/0.92489695
104MP0002938_white_spotting0.92347336
105MP0001177_atelectasis0.91588941
106MP0003656_abnormal_erythrocyte_physiolo0.91479555
107MP0003119_abnormal_digestive_system0.91307696
108MP0009785_altered_susceptibility_to0.91191286
109MP0003315_abnormal_perineum_morphology0.90790881
110MP0005075_abnormal_melanosome_morpholog0.90600671
111MP0002638_abnormal_pupillary_reflex0.88830064
112MP0002277_abnormal_respiratory_mucosa0.88531786
113MP0000733_abnormal_muscle_development0.88422714
114MP0009697_abnormal_copulation0.88211627
115MP0001293_anophthalmia0.86342244
116MP0001873_stomach_inflammation0.86167868
117MP0003935_abnormal_craniofacial_develop0.86154462
118MP0003828_pulmonary_edema0.85544746
119MP0001915_intracranial_hemorrhage0.85380013
120MP0001324_abnormal_eye_pigmentation0.84376280
121MP0001851_eye_inflammation0.82466324
122MP0003861_abnormal_nervous_system0.81634161
123MP0004883_abnormal_blood_vessel0.81367211
124MP0002925_abnormal_cardiovascular_devel0.81222905
125MP0004947_skin_inflammation0.80856139
126MP0002088_abnormal_embryonic_growth/wei0.79630282
127MP0002067_abnormal_sensory_capabilities0.79330218
128MP0003984_embryonic_growth_retardation0.79041062
129MP0002086_abnormal_extraembryonic_tissu0.78996918
130MP0004924_abnormal_behavior0.78814502
131MP0005386_behavior/neurological_phenoty0.78814502
132MP0001485_abnormal_pinna_reflex0.78590998
133MP0002822_catalepsy0.78383657
134MP0001346_abnormal_lacrimal_gland0.78096887
135MP0003448_altered_tumor_morphology0.77656525
136MP0003436_decreased_susceptibility_to0.77096569
137MP0008877_abnormal_DNA_methylation0.76999046
138MP0002752_abnormal_somatic_nervous0.76556940
139MP0005195_abnormal_posterior_eye0.76381636
140MP0000516_abnormal_urinary_system0.76345571
141MP0005367_renal/urinary_system_phenotyp0.76345571
142MP0001672_abnormal_embryogenesis/_devel0.75706120
143MP0005380_embryogenesis_phenotype0.75706120
144MP0004381_abnormal_hair_follicle0.75187754
145MP0005310_abnormal_salivary_gland0.74766414
146MP0002019_abnormal_tumor_incidence0.74179776
147MP0003937_abnormal_limbs/digits/tail_de0.74173155
148MP0008789_abnormal_olfactory_epithelium0.74164372
149MP0002653_abnormal_ependyma_morphology0.73749374
150MP0004133_heterotaxia0.73729392
151MP0006276_abnormal_autonomic_nervous0.73679471
152MP0000377_abnormal_hair_follicle0.73656281
153MP0001286_abnormal_eye_development0.73323892
154MP0009333_abnormal_splenocyte_physiolog0.73225380
155MP0005248_abnormal_Harderian_gland0.71812220
156MP0001929_abnormal_gametogenesis0.71705695
157MP0002075_abnormal_coat/hair_pigmentati0.71113282
158MP0001119_abnormal_female_reproductive0.70547669
159* MP0004811_abnormal_neuron_physiology0.70214071
160MP0001919_abnormal_reproductive_system0.70082152
161MP0003938_abnormal_ear_development0.69678834
162MP0003698_abnormal_male_reproductive0.69210259
163MP0000955_abnormal_spinal_cord0.67287103
164* MP0002152_abnormal_brain_morphology0.67086286
165MP0002184_abnormal_innervation0.66231634
166MP0005084_abnormal_gallbladder_morpholo0.65550964
167MP0000653_abnormal_sex_gland0.65360135

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)4.08010446
2Volvulus (HP:0002580)4.02164138
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.26033182
4Short 4th metacarpal (HP:0010044)3.26033182
5Intestinal atresia (HP:0011100)2.99463419
6Pancreatic cysts (HP:0001737)2.98384938
7Hyperventilation (HP:0002883)2.97281568
8Thyroiditis (HP:0100646)2.94295999
9Pancreatic fibrosis (HP:0100732)2.85754759
10Recurrent viral infections (HP:0004429)2.85073093
11T lymphocytopenia (HP:0005403)2.84818027
12True hermaphroditism (HP:0010459)2.80001963
13Abnormality of the labia minora (HP:0012880)2.77558420
14Abnormality of the nasal septum (HP:0000419)2.73743009
15Subacute progressive viral hepatitis (HP:0006572)2.72395917
16Hepatoblastoma (HP:0002884)2.69765803
17Abnormality of T cell number (HP:0011839)2.67014552
18Hematochezia (HP:0002573)2.63144337
19Drooling (HP:0002307)2.59123941
20Chronic hepatic failure (HP:0100626)2.54071176
21Excessive salivation (HP:0003781)2.49606252
22Medial flaring of the eyebrow (HP:0010747)2.47101957
23B lymphocytopenia (HP:0010976)2.46980732
24Abnormality of B cell number (HP:0010975)2.46980732
25Genital tract atresia (HP:0001827)2.44604089
26Elevated erythrocyte sedimentation rate (HP:0003565)2.36966671
27Progressive inability to walk (HP:0002505)2.36938957
28Macroorchidism (HP:0000053)2.36636696
29Thyroid carcinoma (HP:0002890)2.35456901
30Aplasia/Hypoplasia of the tibia (HP:0005772)2.34372672
31Gait imbalance (HP:0002141)2.33466380
32Congenital primary aphakia (HP:0007707)2.33346622
33Spinal cord lesions (HP:0100561)2.32873317
34Syringomyelia (HP:0003396)2.32873317
35Nephronophthisis (HP:0000090)2.29529952
36Acute myeloid leukemia (HP:0004808)2.28854763
37Recurrent fungal infections (HP:0002841)2.27468086
38Vaginal atresia (HP:0000148)2.24479196
39Protruding tongue (HP:0010808)2.22589798
40Amyotrophic lateral sclerosis (HP:0007354)2.22004544
41Broad-based gait (HP:0002136)2.21027496
42Deep philtrum (HP:0002002)2.19508910
43Colon cancer (HP:0003003)2.15122814
44Abnormal hair whorl (HP:0010721)2.14586175
45Trigonocephaly (HP:0000243)2.14298915
46Long eyelashes (HP:0000527)2.14012323
47Molar tooth sign on MRI (HP:0002419)2.13935179
48Abnormality of midbrain morphology (HP:0002418)2.13935179
49Abnormality of the renal medulla (HP:0100957)2.12226594
50Curly hair (HP:0002212)2.11368146
51Midline defect of the nose (HP:0004122)2.10556477
52Nephrogenic diabetes insipidus (HP:0009806)2.10421480
53Abnormality of the 4th metacarpal (HP:0010012)2.09788930
54Cutis marmorata (HP:0000965)2.09532531
55Short tibia (HP:0005736)2.09064301
56Narrow palate (HP:0000189)2.08736272
57Poor coordination (HP:0002370)2.08507107
58Ectopic kidney (HP:0000086)2.07574154
59Optic nerve hypoplasia (HP:0000609)2.07265027
60Lip pit (HP:0100267)2.02183917
61Absent frontal sinuses (HP:0002688)2.01978237
62Postaxial hand polydactyly (HP:0001162)2.01894455
63Aplasia/Hypoplasia of the tongue (HP:0010295)2.01590928
64Fair hair (HP:0002286)1.98449017
65Viral hepatitis (HP:0006562)1.98370726
66Increased nuchal translucency (HP:0010880)1.97827589
67Truncal obesity (HP:0001956)1.96331060
68Oligodactyly (hands) (HP:0001180)1.95895404
69Hypochromic microcytic anemia (HP:0004840)1.95751387
70Recurrent abscess formation (HP:0002722)1.95739205
71Hip dysplasia (HP:0001385)1.95672490
72Cellulitis (HP:0100658)1.95460423
73Agammaglobulinemia (HP:0004432)1.95363766
74Chromsome breakage (HP:0040012)1.95302113
75Broad foot (HP:0001769)1.95289789
76Proximal placement of thumb (HP:0009623)1.94955313
77Cupped ear (HP:0000378)1.94878608
78Recurrent bacterial skin infections (HP:0005406)1.94163276
79Severe combined immunodeficiency (HP:0004430)1.93314669
80Neoplasm of the adrenal cortex (HP:0100641)1.93170705
81Obsessive-compulsive behavior (HP:0000722)1.92981895
82Septo-optic dysplasia (HP:0100842)1.92737533
83Asymmetry of the thorax (HP:0001555)1.92113009
84Persistence of primary teeth (HP:0006335)1.90097950
85Deviation of the thumb (HP:0009603)1.89949257
86Postaxial foot polydactyly (HP:0001830)1.89537820
87Gastrointestinal atresia (HP:0002589)1.89481255
88Stomach cancer (HP:0012126)1.88924374
89Eosinophilia (HP:0001880)1.87645469
90Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.87380590
91Lymphopenia (HP:0001888)1.87326506
92Inability to walk (HP:0002540)1.87251919
93Abnormal lung lobation (HP:0002101)1.86986297
94Disinhibition (HP:0000734)1.86762292
95Degeneration of the lateral corticospinal tracts (HP:0002314)1.86590832
96Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.86590832
97Cystic hygroma (HP:0000476)1.85951215
98Long clavicles (HP:0000890)1.85890531
99Anencephaly (HP:0002323)1.85751079
100Narrow forehead (HP:0000341)1.85725726
101Panhypogammaglobulinemia (HP:0003139)1.85096422
102Transitional cell carcinoma of the bladder (HP:0006740)1.85008065
103Absent speech (HP:0001344)1.83870767
104Widely spaced teeth (HP:0000687)1.83349372
105Eczematoid dermatitis (HP:0000976)1.82937890
106Hypoplastic iliac wings (HP:0002866)1.81757122
107Periodontitis (HP:0000704)1.81076826
108Thrombocytosis (HP:0001894)1.81055512
109Increased density of long bones (HP:0006392)1.80869467
110Recurrent bronchitis (HP:0002837)1.80750902
111Supernumerary spleens (HP:0009799)1.80724673
112Growth hormone deficiency (HP:0000824)1.80247843
113Specific learning disability (HP:0001328)1.79783420
114Thick eyebrow (HP:0000574)1.79324574
115Gaze-evoked nystagmus (HP:0000640)1.79283117
116Abnormality of cells of the lymphoid lineage (HP:0012140)1.78925238
117Genetic anticipation (HP:0003743)1.77685192
118Heterotopia (HP:0002282)1.77450186
119Leukocytosis (HP:0001974)1.77395246
120Cortical dysplasia (HP:0002539)1.76351651
121Abnormality of eosinophils (HP:0001879)1.75313415
122Myositis (HP:0100614)1.75037077
123Meningitis (HP:0001287)1.74877342
124Median cleft lip (HP:0000161)1.74387419
125Inappropriate behavior (HP:0000719)1.72862408
126Abnormality of T cells (HP:0002843)1.72395233
127Abnormality of chromosome stability (HP:0003220)1.71146744
128Renal hypoplasia (HP:0000089)1.70598895
129Dislocated radial head (HP:0003083)1.70572539
130Lymphoma (HP:0002665)1.70080162
131Chronic otitis media (HP:0000389)1.69925395
132Preaxial hand polydactyly (HP:0001177)1.68772060
133Neoplasm of the tracheobronchial system (HP:0100552)1.68388720
134Progressive cerebellar ataxia (HP:0002073)1.68220453
135Lissencephaly (HP:0001339)1.67805838
136Biliary tract neoplasm (HP:0100574)1.67704487
137Abnormality of salivation (HP:0100755)1.67560486
138Papillary thyroid carcinoma (HP:0002895)1.66689767
139Abnormality of the renal cortex (HP:0011035)1.66085027
140Papilledema (HP:0001085)1.66019017
141Malignant gastrointestinal tract tumors (HP:0006749)1.65432570
142Gastrointestinal carcinoma (HP:0002672)1.65432570
143IgM deficiency (HP:0002850)1.64486822
144High anterior hairline (HP:0009890)1.64152566
145Vitreoretinal degeneration (HP:0000655)1.63568309
146Bladder carcinoma (HP:0002862)1.63334092
147Bladder neoplasm (HP:0009725)1.63334092
148Mediastinal lymphadenopathy (HP:0100721)1.63297439
149Abnormality of chromosome segregation (HP:0002916)1.62801892
150Stomatitis (HP:0010280)1.62576997
151Abnormality of the columella (HP:0009929)1.62504646
152Pachygyria (HP:0001302)1.62213141
153Abnormal delayed hypersensitivity skin test (HP:0002963)1.61647339
154Sloping forehead (HP:0000340)1.61596103
155Bicuspid aortic valve (HP:0001647)1.61285722
156Dandy-Walker malformation (HP:0001305)1.60517905
157Medulloblastoma (HP:0002885)1.60122584
158Acute lymphatic leukemia (HP:0006721)1.59127313
159Myelodysplasia (HP:0002863)1.58476067
160Abnormality of the radial head (HP:0003995)1.58439669
161Gonadotropin excess (HP:0000837)1.58408714
162Smooth philtrum (HP:0000319)1.57781568
163Combined immunodeficiency (HP:0005387)1.57618570
164Abnormality of the right ventricle (HP:0001707)1.57412516
165Facial hemangioma (HP:0000329)1.56208381
166Prominent nose (HP:0000448)1.56173979
167Pancreatic islet-cell hyperplasia (HP:0004510)1.56143048
168Vasculitis (HP:0002633)1.55662720
169Urethral obstruction (HP:0000796)1.55639789
170Neoplasm of the oral cavity (HP:0100649)1.54249666
171Abnormality of the intervertebral disk (HP:0005108)1.54232915
172Aplasia/Hypoplasia of the sternum (HP:0006714)1.53743561
173Aqueductal stenosis (HP:0002410)1.53134368
174Verrucae (HP:0200043)1.52665269
175Papilloma (HP:0012740)1.52665269
176IgA deficiency (HP:0002720)1.51796063
177Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.51428347
178High pitched voice (HP:0001620)1.50872946
179Chromosomal breakage induced by crosslinking agents (HP:0003221)1.50646425

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.58609120
2TNIK3.00726833
3WNK32.73034080
4MAP4K12.51429794
5NUAK12.50324012
6CDK122.36806766
7BCR2.34914716
8MAP3K42.20408545
9TRIM282.17455619
10MKNK12.16511709
11CDC72.13983096
12IRAK42.13114382
13MKNK22.11982841
14TXK2.11114111
15MAP3K102.10591444
16FGFR32.07915469
17MAP4K21.97384960
18STK101.96750085
19ERBB31.95199876
20BRD41.85994080
21MAP3K141.83692790
22CDK61.79284318
23SRPK11.76705480
24SIK21.70605826
25EEF2K1.69547999
26FRK1.65728070
27JAK31.64355269
28NEK21.60770684
29CAMK1D1.54520629
30MAPK131.54298493
31FGFR21.51418587
32TEC1.50859151
33MARK11.50051103
34ITK1.49852255
35AKT31.41921848
36CDK91.41739696
37TGFBR11.41112643
38KSR11.40069801
39CAMK1G1.40005678
40PTK61.38517192
41DYRK21.34447123
42* ATR1.29163096
43CHUK1.28549620
44IKBKE1.28088857
45MAP2K71.27489711
46CLK11.27423237
47TYK21.26382105
48JAK11.25997270
49CAMKK21.25444377
50STK41.23043084
51STK31.22542083
52PASK1.20130019
53STK38L1.19886231
54MELK1.18695735
55PLK41.16878358
56PAK31.16389402
57BTK1.16292878
58PLK21.13140504
59INSRR1.13013675
60PLK31.06995206
61MARK31.05727993
62PNCK1.04421012
63CSNK1G21.03107296
64PINK11.02734143
65LATS10.99891528
66ZAK0.99029490
67IRAK10.98310728
68EPHA30.97727139
69FGR0.97248151
70EIF2AK30.95968415
71CSF1R0.95840353
72YES10.94658141
73SYK0.94327915
74VRK10.93395793
75TLK10.92453232
76TAF10.91877990
77LCK0.91650443
78* SGK20.91079981
79PIM10.90018049
80* ATM0.88965596
81CSNK1G10.87634653
82NEK90.86606519
83BLK0.85538446
84RIPK10.85336173
85CDK30.85059650
86WEE10.83096727
87CDK40.82843404
88KIT0.82691782
89TGFBR20.82314556
90DYRK1A0.80911793
91SIK30.80252816
92ZAP700.80249478
93SIK10.79489218
94HCK0.78394592
95LRRK20.77477607
96GRK60.75696216
97CHEK10.75575255
98PDGFRB0.74949950
99TAOK30.74928603
100ACVR1B0.72476091
101TRPM70.69997950
102DMPK0.69484905
103CSNK1G30.69371397
104RPS6KB20.69304538
105AURKB0.68964457
106IKBKB0.68582041
107CSK0.68455996
108CSNK1A1L0.67604137
109ALK0.66827914
110NLK0.66243528
111* HIPK20.65613779
112PRKCQ0.65123685
113EPHA40.64540711
114RPS6KB10.62783916
115OXSR10.62405963
116EGFR0.61850175
117WNK10.61675732
118SCYL20.60843737
119MST40.60428764
120MINK10.60203441
121CHEK20.60093871
122EPHB10.59370331
123NTRK20.57889652
124UHMK10.57836817
125* SGK4940.57607467
126* SGK2230.57607467
127LYN0.57439614
128PRKDC0.57394106
129CDK20.56240144
130NTRK30.56153574
131GRK10.56104000
132CDK80.53894066
133BMPR1B0.53528874
134FGFR10.52509742
135STK110.52467921
136CDK10.52196451
137* PRKCE0.51762642
138* MAPK140.50239976
139DYRK1B0.49462906
140CSNK1D0.49191235
141BRSK20.48229571
142ADRBK20.47757780
143FES0.47736355
144MAP3K20.46922377
145* DYRK30.46644463
146STK390.45570022
147MAP2K40.43999444
148TSSK60.43396961
149JAK20.42927535
150MAPK70.42887551
151* AKT10.42749349
152ERBB20.42527219
153PRKCZ0.39915295

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.09616473
2Basal transcription factors_Homo sapiens_hsa030222.00467021
3Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.97330323
4Nicotine addiction_Homo sapiens_hsa050331.95742217
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.87935692
6Protein export_Homo sapiens_hsa030601.81935492
7NF-kappa B signaling pathway_Homo sapiens_hsa040641.81313512
8Regulation of autophagy_Homo sapiens_hsa041401.70336899
9B cell receptor signaling pathway_Homo sapiens_hsa046621.66958278
10Non-homologous end-joining_Homo sapiens_hsa034501.63330367
11T cell receptor signaling pathway_Homo sapiens_hsa046601.54603012
12Chronic myeloid leukemia_Homo sapiens_hsa052201.53188295
13Measles_Homo sapiens_hsa051621.52821686
14Transcriptional misregulation in cancer_Homo sapiens_hsa052021.51047551
15Systemic lupus erythematosus_Homo sapiens_hsa053221.50136923
16Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.45653159
17Leishmaniasis_Homo sapiens_hsa051401.43996802
18* Antigen processing and presentation_Homo sapiens_hsa046121.41886928
19Propanoate metabolism_Homo sapiens_hsa006401.41134220
20Olfactory transduction_Homo sapiens_hsa047401.40908598
21Cell cycle_Homo sapiens_hsa041101.38552078
22* Osteoclast differentiation_Homo sapiens_hsa043801.38278844
23Hedgehog signaling pathway_Homo sapiens_hsa043401.35702097
24Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.35215437
25Steroid biosynthesis_Homo sapiens_hsa001001.35042418
26Herpes simplex infection_Homo sapiens_hsa051681.34652995
27MicroRNAs in cancer_Homo sapiens_hsa052061.34085195
28Colorectal cancer_Homo sapiens_hsa052101.33291113
29NOD-like receptor signaling pathway_Homo sapiens_hsa046211.31767255
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.31209950
31Taste transduction_Homo sapiens_hsa047421.30210090
32Small cell lung cancer_Homo sapiens_hsa052221.28791582
33Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.27849937
34Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.27078794
35Pancreatic cancer_Homo sapiens_hsa052121.25832594
36* Hepatitis B_Homo sapiens_hsa051611.21940906
37Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.21637196
38* Viral carcinogenesis_Homo sapiens_hsa052031.20536232
39Hematopoietic cell lineage_Homo sapiens_hsa046401.19998138
40Axon guidance_Homo sapiens_hsa043601.18896744
41Mismatch repair_Homo sapiens_hsa034301.18852719
42* HTLV-I infection_Homo sapiens_hsa051661.18803265
43DNA replication_Homo sapiens_hsa030301.17753786
44mRNA surveillance pathway_Homo sapiens_hsa030151.17635960
45Long-term depression_Homo sapiens_hsa047301.17282212
46Toxoplasmosis_Homo sapiens_hsa051451.17204736
47Spliceosome_Homo sapiens_hsa030401.16521543
48Toll-like receptor signaling pathway_Homo sapiens_hsa046201.16052503
49Glutamatergic synapse_Homo sapiens_hsa047241.15860765
50Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.15324230
51Leukocyte transendothelial migration_Homo sapiens_hsa046701.13670433
52Viral myocarditis_Homo sapiens_hsa054161.13490998
53Chemokine signaling pathway_Homo sapiens_hsa040621.07852257
54Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.07663817
55Fanconi anemia pathway_Homo sapiens_hsa034601.07559048
56Non-small cell lung cancer_Homo sapiens_hsa052231.07250197
57RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.06897811
58Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.06496835
59Endometrial cancer_Homo sapiens_hsa052131.05891999
60* Prostate cancer_Homo sapiens_hsa052151.05471019
61Influenza A_Homo sapiens_hsa051641.04659474
62Jak-STAT signaling pathway_Homo sapiens_hsa046301.02712363
63Morphine addiction_Homo sapiens_hsa050321.02104871
64Butanoate metabolism_Homo sapiens_hsa006501.01544489
65Platelet activation_Homo sapiens_hsa046111.01488308
66Graft-versus-host disease_Homo sapiens_hsa053321.01431419
67Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.01232683
68Ether lipid metabolism_Homo sapiens_hsa005650.98229724
69AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97766658
70Neurotrophin signaling pathway_Homo sapiens_hsa047220.97202079
71Oocyte meiosis_Homo sapiens_hsa041140.95838486
72* TNF signaling pathway_Homo sapiens_hsa046680.95149273
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.93807047
74Adherens junction_Homo sapiens_hsa045200.93358252
75Acute myeloid leukemia_Homo sapiens_hsa052210.92706390
76GABAergic synapse_Homo sapiens_hsa047270.91779920
77Base excision repair_Homo sapiens_hsa034100.89930633
78Apoptosis_Homo sapiens_hsa042100.89802749
79* Alcoholism_Homo sapiens_hsa050340.89736186
80RNA degradation_Homo sapiens_hsa030180.88022588
81FoxO signaling pathway_Homo sapiens_hsa040680.86892059
82* Dopaminergic synapse_Homo sapiens_hsa047280.86312815
83Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.86059710
84Phosphatidylinositol signaling system_Homo sapiens_hsa040700.85272033
85Allograft rejection_Homo sapiens_hsa053300.84726358
86Notch signaling pathway_Homo sapiens_hsa043300.84180954
87Proteoglycans in cancer_Homo sapiens_hsa052050.84117037
88Serotonergic synapse_Homo sapiens_hsa047260.83833308
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83562945
90Thyroid hormone signaling pathway_Homo sapiens_hsa049190.83321626
91Epstein-Barr virus infection_Homo sapiens_hsa051690.82661247
92Prolactin signaling pathway_Homo sapiens_hsa049170.82298635
93Glioma_Homo sapiens_hsa052140.82294539
94Homologous recombination_Homo sapiens_hsa034400.80622495
95Pathways in cancer_Homo sapiens_hsa052000.79131184
96* Circadian entrainment_Homo sapiens_hsa047130.77793099
97Renal cell carcinoma_Homo sapiens_hsa052110.75749852
98RNA transport_Homo sapiens_hsa030130.75609494
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.73976107
100Selenocompound metabolism_Homo sapiens_hsa004500.73945646
101Gap junction_Homo sapiens_hsa045400.73671178
102mTOR signaling pathway_Homo sapiens_hsa041500.73218433
103Lysine degradation_Homo sapiens_hsa003100.72970102
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.72645670
105Pertussis_Homo sapiens_hsa051330.72583007
106Legionellosis_Homo sapiens_hsa051340.72206277
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.71842654
108Hepatitis C_Homo sapiens_hsa051600.70748791
109Autoimmune thyroid disease_Homo sapiens_hsa053200.70307418
110Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70045506
111Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.69280109
112Inositol phosphate metabolism_Homo sapiens_hsa005620.69144291
113Nitrogen metabolism_Homo sapiens_hsa009100.69013177
114Ras signaling pathway_Homo sapiens_hsa040140.68830702
115Focal adhesion_Homo sapiens_hsa045100.68446620
116p53 signaling pathway_Homo sapiens_hsa041150.68107075
117Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67960699
118Type II diabetes mellitus_Homo sapiens_hsa049300.67403206
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.67090195
120Basal cell carcinoma_Homo sapiens_hsa052170.66693238
121Asthma_Homo sapiens_hsa053100.66634225
122Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.66334161
123Wnt signaling pathway_Homo sapiens_hsa043100.66192341
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.65366558
125* Tuberculosis_Homo sapiens_hsa051520.65278241
126Nucleotide excision repair_Homo sapiens_hsa034200.64006993
127MAPK signaling pathway_Homo sapiens_hsa040100.63920389
128TGF-beta signaling pathway_Homo sapiens_hsa043500.63791881
129Hippo signaling pathway_Homo sapiens_hsa043900.63783697
130Phototransduction_Homo sapiens_hsa047440.61558293
131Shigellosis_Homo sapiens_hsa051310.60327152
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.60264481
133Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.59385415
134Dorso-ventral axis formation_Homo sapiens_hsa043200.58622618
135alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.58604623
136* cAMP signaling pathway_Homo sapiens_hsa040240.58175349
137Choline metabolism in cancer_Homo sapiens_hsa052310.57717992
138* Cholinergic synapse_Homo sapiens_hsa047250.53881820
139* Circadian rhythm_Homo sapiens_hsa047100.50597900
140* Amphetamine addiction_Homo sapiens_hsa050310.49686654
141Linoleic acid metabolism_Homo sapiens_hsa005910.47761375
142Rap1 signaling pathway_Homo sapiens_hsa040150.47128272
143* Renin secretion_Homo sapiens_hsa049240.46546796
144Melanoma_Homo sapiens_hsa052180.44663611
145Oxytocin signaling pathway_Homo sapiens_hsa049210.42859185

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