CREB3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1Golgi transport vesicle coating (GO:0048200)6.08454927
2COPI coating of Golgi vesicle (GO:0048205)6.08454927
3maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.56950713
4protein retention in ER lumen (GO:0006621)4.55358971
5mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.11149357
6fatty acid elongation (GO:0030497)4.10844659
7GDP-mannose metabolic process (GO:0019673)4.06893027
8signal peptide processing (GO:0006465)4.03010557
9proteasome assembly (GO:0043248)4.02921767
10regulation of cellular amino acid metabolic process (GO:0006521)3.87896683
11type B pancreatic cell proliferation (GO:0044342)3.87335315
12retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.85773031
13ER overload response (GO:0006983)3.71858326
14nuclear envelope reassembly (GO:0031468)3.66589668
15mitotic nuclear envelope reassembly (GO:0007084)3.66589668
16positive regulation of mitochondrial fission (GO:0090141)3.57291024
17iron-sulfur cluster assembly (GO:0016226)3.56318871
18metallo-sulfur cluster assembly (GO:0031163)3.56318871
19mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.52748916
20ATP hydrolysis coupled proton transport (GO:0015991)3.45453416
21energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.45453416
22negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.43629776
23protein deneddylation (GO:0000338)3.41273139
24axon ensheathment in central nervous system (GO:0032291)3.35782639
25central nervous system myelination (GO:0022010)3.35782639
26ATP synthesis coupled proton transport (GO:0015986)3.34256223
27energy coupled proton transport, down electrochemical gradient (GO:0015985)3.34256223
28respiratory electron transport chain (GO:0022904)3.25781979
29transferrin transport (GO:0033572)3.25443935
30cullin deneddylation (GO:0010388)3.25089619
31protein neddylation (GO:0045116)3.24791190
32electron transport chain (GO:0022900)3.19333369
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.18973957
34phagosome maturation (GO:0090382)3.18928427
35dolichol-linked oligosaccharide biosynthetic process (GO:0006488)3.17191212
36presynaptic membrane assembly (GO:0097105)3.14715890
37ferric iron transport (GO:0015682)3.14036328
38trivalent inorganic cation transport (GO:0072512)3.14036328
39DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.12666549
40negative regulation of ligase activity (GO:0051352)3.11277504
41negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.11277504
42long-chain fatty acid biosynthetic process (GO:0042759)3.11221978
43lipopolysaccharide biosynthetic process (GO:0009103)3.10329064
44positive regulation of actin filament depolymerization (GO:0030836)3.06748877
45COPII vesicle coating (GO:0048208)3.03659905
46extracellular fibril organization (GO:0043206)3.03359535
47positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03340422
48ER to Golgi vesicle-mediated transport (GO:0006888)3.01487219
49neuron cell-cell adhesion (GO:0007158)3.00791058
50intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97874382
51signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97874382
52cell adhesion mediated by integrin (GO:0033627)2.94735660
53aldehyde catabolic process (GO:0046185)2.92867229
54negative regulation of neurotransmitter transport (GO:0051589)2.89539647
55signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.88701319
56signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.88701319
57signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.88701319
58negative regulation of neurotransmitter secretion (GO:0046929)2.88513151
59regulation of autophagic vacuole assembly (GO:2000785)2.87458958
60UV protection (GO:0009650)2.87149149
61regulation of integrin-mediated signaling pathway (GO:2001044)2.86015460
62pH reduction (GO:0045851)2.85908679
63skin morphogenesis (GO:0043589)2.85606852
64regulation of metalloenzyme activity (GO:0048552)2.85407546
65positive regulation of protein targeting to membrane (GO:0090314)2.83837477
66nucleotide-sugar biosynthetic process (GO:0009226)2.83703059
67virion attachment to host cell (GO:0019062)2.83069668
68adhesion of symbiont to host cell (GO:0044650)2.83069668
69presynaptic membrane organization (GO:0097090)2.82689645
70regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.81383146
71regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.81080385
72macroautophagy (GO:0016236)2.80947385
73vesicle coating (GO:0006901)2.80786781
74negative regulation of JAK-STAT cascade (GO:0046426)2.80412870
75activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c (GO2.77652449
76signal transduction involved in DNA damage checkpoint (GO:0072422)2.76035913
77signal transduction involved in DNA integrity checkpoint (GO:0072401)2.76035913
78regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)2.74739752
79regulation of cellular amine metabolic process (GO:0033238)2.74140494
80signal transduction involved in cell cycle checkpoint (GO:0072395)2.72307286
814-hydroxyproline metabolic process (GO:0019471)2.71667129
82positive regulation of TOR signaling (GO:0032008)2.70471700
83antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.70034495
84regulation of protein targeting to membrane (GO:0090313)2.68558124
85peptidyl-proline hydroxylation (GO:0019511)2.68001293
86coenzyme catabolic process (GO:0009109)2.66564068
87actin filament depolymerization (GO:0030042)2.65210630
88intracellular pH reduction (GO:0051452)2.64796878
89nucleotide transmembrane transport (GO:1901679)2.63868170
90protein complex biogenesis (GO:0070271)2.62972460
91response to gravity (GO:0009629)2.62283243
92regulation of cilium movement (GO:0003352)2.61100081
93chaperone-mediated protein transport (GO:0072321)2.58437078
94protein targeting to mitochondrion (GO:0006626)2.58047845
95negative regulation of JUN kinase activity (GO:0043508)2.57921501
96positive regulation of mitochondrial calcium ion concentration (GO:0051561)2.57014438
97substantia nigra development (GO:0021762)2.55898415
98positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.55825433
99cholesterol biosynthetic process (GO:0006695)2.53723922
100dopamine biosynthetic process (GO:0042416)2.52919597
101platelet dense granule organization (GO:0060155)2.52800797
102C-terminal protein lipidation (GO:0006501)2.52487501
103protein hydroxylation (GO:0018126)2.52345735
104termination of RNA polymerase III transcription (GO:0006386)2.51145081
105transcription elongation from RNA polymerase III promoter (GO:0006385)2.51145081
106fibril organization (GO:0097435)2.50348915
107endoplasmic reticulum calcium ion homeostasis (GO:0032469)2.50322869
108anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.49242165
109response to redox state (GO:0051775)2.48219596
110cofactor catabolic process (GO:0051187)2.45815962
111hydrogen ion transmembrane transport (GO:1902600)2.45573503
112de novo posttranslational protein folding (GO:0051084)2.44594417
113antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.42695460
114establishment of protein localization to mitochondrion (GO:0072655)2.42280932
115L-serine transport (GO:0015825)2.41651058
116regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.40934968
117L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.40761299
118activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.40204287
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.39961191
120mitochondrial respiratory chain complex I assembly (GO:0032981)2.39961191
121NADH dehydrogenase complex assembly (GO:0010257)2.39961191
122galactose catabolic process (GO:0019388)2.39818698
123copper ion homeostasis (GO:0055070)2.39794008
124positive regulation of ligase activity (GO:0051351)2.38618743
125lipopolysaccharide metabolic process (GO:0008653)2.38413150
126positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.37157018
127barbed-end actin filament capping (GO:0051016)2.36260502
128regulation of vacuole organization (GO:0044088)2.35731610
129regulation of dopamine metabolic process (GO:0042053)2.35583192
130regulation of catecholamine metabolic process (GO:0042069)2.35583192
131proton transport (GO:0015992)2.35545856
132peptidyl-proline modification (GO:0018208)2.35278242
133galactose metabolic process (GO:0006012)2.35037901
134isoprenoid biosynthetic process (GO:0008299)2.34616524
135heart contraction (GO:0060047)2.34261963
136heart process (GO:0003015)2.34261963
137limb bud formation (GO:0060174)2.31147780
138short-term memory (GO:0007614)2.31085933
139photoreceptor cell differentiation (GO:0046530)2.30689377
140eye photoreceptor cell differentiation (GO:0001754)2.30689377
141hydrogen transport (GO:0006818)2.30337694
142adhesion of symbiont to host (GO:0044406)2.29479966
143mannosylation (GO:0097502)2.28102377
144glycosylceramide metabolic process (GO:0006677)2.24985511
145amyloid precursor protein catabolic process (GO:0042987)2.23963208
146neuronal action potential propagation (GO:0019227)2.22751551
147sterol biosynthetic process (GO:0016126)2.21107335
148mitochondrial calcium ion homeostasis (GO:0051560)2.19744796
149regulation of collateral sprouting (GO:0048670)2.19470837
150positive regulation of amino acid transport (GO:0051957)2.19294602
151fatty-acyl-CoA metabolic process (GO:0035337)2.17611501
152membrane assembly (GO:0071709)2.17202705
153negative regulation of synaptic transmission, GABAergic (GO:0032229)2.17034645
154negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.15124640
155iron ion transport (GO:0006826)2.14853306
156long-chain fatty-acyl-CoA metabolic process (GO:0035336)2.14442248
157amyloid precursor protein metabolic process (GO:0042982)2.13354522
158myelination (GO:0042552)2.11390278
159ensheathment of neurons (GO:0007272)2.11049973
160axon ensheathment (GO:0008366)2.11049973
161cellular copper ion homeostasis (GO:0006878)2.10806649
162negative regulation of protein localization to cell surface (GO:2000009)2.10773384
163GTP biosynthetic process (GO:0006183)2.09099928
164heme transport (GO:0015886)2.08892298
165nucleotide transport (GO:0006862)2.08308143
166mitochondrial respiratory chain complex assembly (GO:0033108)2.07485887
167pyrimidine-containing compound transmembrane transport (GO:0072531)2.07461620
168protein maturation by protein folding (GO:0022417)2.05953147
169erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.04620955
170L-phenylalanine catabolic process (GO:0006559)2.04620955
171long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.04209910
172response to dietary excess (GO:0002021)2.04078396
173eosinophil chemotaxis (GO:0048245)2.03810785
174regulation of glutamate secretion (GO:0014048)2.03708045
175mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.02642271
176cellular iron ion homeostasis (GO:0006879)2.02526300
177negative regulation of acute inflammatory response (GO:0002674)2.02442142
178glycerophospholipid catabolic process (GO:0046475)2.01951568
179synaptic vesicle exocytosis (GO:0016079)2.01510338
180peptide hormone processing (GO:0016486)2.01223895
181leukocyte migration involved in inflammatory response (GO:0002523)2.00002666
182glycosphingolipid catabolic process (GO:0046479)1.99164516
183positive regulation of synapse assembly (GO:0051965)1.99036317
184purine ribonucleotide transport (GO:0015868)1.98776367
185magnesium ion transport (GO:0015693)1.97201376
186positive regulation of action potential (GO:0045760)1.95552513
187detection of temperature stimulus involved in sensory perception of pain (GO:0050965)1.95511049
188detection of temperature stimulus involved in sensory perception (GO:0050961)1.95511049
189glycolipid catabolic process (GO:0019377)1.94957155

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat6.07259244
2NOTCH1_17114293_ChIP-ChIP_T-ALL_Human4.49577716
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.71208214
4GABP_17652178_ChIP-ChIP_JURKAT_Human3.56687672
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.51647015
6GBX2_23144817_ChIP-Seq_PC3_Human3.08347452
7CREB1_15753290_ChIP-ChIP_HEK293T_Human3.04799227
8* ETS1_20019798_ChIP-Seq_JURKAT_Human2.88444210
9* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human2.55523296
10TAF15_26573619_Chip-Seq_HEK293_Human2.36939380
11SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.21605187
12TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.14702826
13EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.14650402
14SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.14478443
15GABP_19822575_ChIP-Seq_HepG2_Human2.14309735
16DMRT1_21621532_ChIP-ChIP_FETAL_Ovary2.13251187
17VDR_22108803_ChIP-Seq_LS180_Human2.11144385
18CEBPB_24764292_ChIP-Seq_MC3T3_Mouse2.10633532
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10431255
20HIF1A_21447827_ChIP-Seq_MCF-7_Human2.09321238
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.05366955
22SRF_21415370_ChIP-Seq_HL-1_Mouse2.01202400
23* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.01103192
24SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.00967849
25GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.99895104
26SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.98235936
27IGF1R_20145208_ChIP-Seq_DFB_Human1.96870426
28EZH2_22144423_ChIP-Seq_EOC_Human1.95584752
29YY1_21170310_ChIP-Seq_MESCs_Mouse1.94185790
30* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.93535570
31DCP1A_22483619_ChIP-Seq_HELA_Human1.93244192
32EST1_17652178_ChIP-ChIP_JURKAT_Human1.92357560
33NRF2_20460467_ChIP-Seq_MEFs_Mouse1.91792748
34NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.91792748
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.91673133
36HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.90543031
37CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85059454
38TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.83556704
39CDX2_19796622_ChIP-Seq_MESCs_Mouse1.82578880
40SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.82300042
41MYC_18358816_ChIP-ChIP_MESCs_Mouse1.82085455
42E2F1_18555785_ChIP-Seq_MESCs_Mouse1.81860804
43EED_16625203_ChIP-ChIP_MESCs_Mouse1.81150339
44MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79183228
45* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.77670554
46CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.74378789
47BMI1_23680149_ChIP-Seq_NPCS_Mouse1.74355091
48SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.71406057
49SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.69510429
50ER_23166858_ChIP-Seq_MCF-7_Human1.68929942
51ELF1_17652178_ChIP-ChIP_JURKAT_Human1.67624508
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.67476654
53JARID2_20064375_ChIP-Seq_MESCs_Mouse1.65765735
54TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.65428629
55MTF2_20144788_ChIP-Seq_MESCs_Mouse1.64045651
56ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.63407529
57POU3F2_20337985_ChIP-ChIP_501MEL_Human1.63164601
58OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.62946148
59PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62147726
60TET1_21451524_ChIP-Seq_MESCs_Mouse1.61893206
61EZH2_27304074_Chip-Seq_ESCs_Mouse1.61531942
62EZH2_18974828_ChIP-Seq_MESCs_Mouse1.60768398
63RNF2_18974828_ChIP-Seq_MESCs_Mouse1.60768398
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.59705224
65ELK1_22589737_ChIP-Seq_MCF10A_Human1.57993063
66PIAS1_25552417_ChIP-Seq_VCAP_Human1.54580951
67TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.54080539
68WT1_19549856_ChIP-ChIP_CCG9911_Human1.48315078
69ZNF263_19887448_ChIP-Seq_K562_Human1.48256343
70CTBP1_25329375_ChIP-Seq_LNCAP_Human1.45919304
71P300_19829295_ChIP-Seq_ESCs_Human1.45651557
72NELFA_20434984_ChIP-Seq_ESCs_Mouse1.44972110
73TP53_18474530_ChIP-ChIP_U2OS_Human1.42948448
74E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.42267326
75SUZ12_27294783_Chip-Seq_ESCs_Mouse1.40288120
76TOP2B_26459242_ChIP-Seq_MCF-7_Human1.40020669
77XRN2_22483619_ChIP-Seq_HELA_Human1.39352258
78HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.39189960
79CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.39107210
80EZH2_27294783_Chip-Seq_ESCs_Mouse1.37653145
81SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.36618995
82VDR_23849224_ChIP-Seq_CD4+_Human1.32610224
83CTCF_18555785_ChIP-Seq_MESCs_Mouse1.31691505
84PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30771472
85PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.30266429
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.29174606
87PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse1.28429663
88GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.28406402
89CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.27172806
90SRY_22984422_ChIP-ChIP_TESTIS_Rat1.25662574
91TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23566001
92SMAD4_21799915_ChIP-Seq_A2780_Human1.22956436
93THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.22814755
94ELK1_19687146_ChIP-ChIP_HELA_Human1.22724035
95CBX2_27304074_Chip-Seq_ESCs_Mouse1.22314269
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.21708310
97TBX5_21415370_ChIP-Seq_HL-1_Mouse1.21340293
98UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.20605455
99PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.20106082
100CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.18977789
101SOX2_20726797_ChIP-Seq_SW620_Human1.17624156
102SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.16698459
103* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.16480783
104SMAD3_21741376_ChIP-Seq_EPCs_Human1.16290931
105* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15870985
106CSB_26484114_Chip-Seq_FIBROBLAST_Human1.13921607
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.12844585
108NR3C1_23031785_ChIP-Seq_PC12_Mouse1.12321512
109ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.12147826
110FOXP1_21924763_ChIP-Seq_HESCs_Human1.11076749
111CTCF_20526341_ChIP-Seq_ESCs_Human1.10509928
112ELK3_25401928_ChIP-Seq_HUVEC_Human1.09883716
113FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.08701378
114* TP53_22127205_ChIP-Seq_IMR90_Human1.08580077
115ATF3_27146783_Chip-Seq_COLON_Human1.08191593
116* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.08060602
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07977418
118SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07332869
119TP63_17297297_ChIP-ChIP_HaCaT_Human1.06926199
120PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06876930
121MYC_18555785_ChIP-Seq_MESCs_Mouse1.06383987
122AR_21572438_ChIP-Seq_LNCaP_Human1.06147014
123RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.05990102
124BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05307068
125NANOG_18555785_Chip-Seq_ESCs_Mouse1.05283668
126EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05012681
127UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04251626
128JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.04035442
129NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.03998612
130MYC_19030024_ChIP-ChIP_MESCs_Mouse1.03946280
131EOMES_21245162_ChIP-Seq_HESCs_Human1.03600386
132TFEB_21752829_ChIP-Seq_HELA_Human1.03365638
133KDM2B_26808549_Chip-Seq_REH_Human1.03337974
134JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.02993148
135AR_25329375_ChIP-Seq_VCAP_Human1.02889330
136REST_21632747_ChIP-Seq_MESCs_Mouse1.02743409
137JUN_21703547_ChIP-Seq_K562_Human1.01772203
138* NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.01315560
139CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.00540586
140HTT_18923047_ChIP-ChIP_STHdh_Human1.00527661
141CJUN_26792858_Chip-Seq_BT549_Human1.00138195
142RNF2_27304074_Chip-Seq_ESCs_Mouse0.99392768
143GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.99368585
144EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.99196997
145FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.99190500
146SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98714825
147BCL6_27268052_Chip-Seq_Bcells_Human0.98498590
148* RUNX2_22187159_ChIP-Seq_PCA_Human0.97171783
149* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.97157230
150SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.95814359
151P53_22387025_ChIP-Seq_ESCs_Mouse0.95307537
152NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.95210249
153FOXP3_21729870_ChIP-Seq_TREG_Human0.94690573
154NANOG_19829295_ChIP-Seq_ESCs_Human0.94181737
155SOX2_19829295_ChIP-Seq_ESCs_Human0.94181737
156CLOCK_20551151_ChIP-Seq_293T_Human0.93825382
157CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.93397337
158SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93317717
159FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.93277709
160RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.92901091
161STAT3_18555785_Chip-Seq_ESCs_Mouse0.92550316
162LXR_22292898_ChIP-Seq_THP-1_Human0.91918976
163RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.91525998
164MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.91273332
165CMYC_18555785_Chip-Seq_ESCs_Mouse0.90893743
166IRF8_21731497_ChIP-ChIP_J774_Mouse0.90891158
167* RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.90883478
168ZFX_18555785_ChIP-Seq_MESCs_Mouse0.90742425
169EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.90179847
170TTF2_22483619_ChIP-Seq_HELA_Human0.89644119
171RARG_19884340_ChIP-ChIP_MEFs_Mouse0.88729881
172TAL1_26923725_Chip-Seq_HPCs_Mouse0.88102330
173TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.87835191
174SOX2_18555785_Chip-Seq_ESCs_Mouse0.87554505
175* RARA_24833708_ChIP-Seq_LIVER_Mouse0.87147023
176PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.86996233
177NANOG_18555785_ChIP-Seq_MESCs_Mouse0.86924225
178TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.86894937
179NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.86390770
180* RARB_24833708_ChIP-Seq_LIVER_Mouse0.86345723
181EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.85978012
182BCAT_22108803_ChIP-Seq_LS180_Human0.85882861
183ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.85568194
184PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.85248353
185PCGF2_27294783_Chip-Seq_ESCs_Mouse0.85221053
186SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.85087813
187ZNF217_24962896_ChIP-Seq_MCF-7_Human0.84827150
188IKZF1_21737484_ChIP-ChIP_HCT116_Human0.84698856
189ERG_21242973_ChIP-ChIP_JURKAT_Human0.84355790
190FUS_26573619_Chip-Seq_HEK293_Human0.84303355
191EP300_21415370_ChIP-Seq_HL-1_Mouse0.84245261
192ARNT_22903824_ChIP-Seq_MCF-7_Human0.83189739
193P300_18555785_Chip-Seq_ESCs_Mouse0.82765715
194MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.82304531
195VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81720605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010386_abnormal_urinary_bladder3.46922439
2MP0003880_abnormal_central_pattern3.30346410
3MP0006054_spinal_hemorrhage3.16309815
4MP0000013_abnormal_adipose_tissue2.72649473
5MP0003183_abnormal_peptide_metabolism2.66148929
6MP0010030_abnormal_orbit_morphology2.62747085
7MP0005257_abnormal_intraocular_pressure2.62377545
8MP0003279_aneurysm2.58810155
9MP0009840_abnormal_foam_cell2.49949099
10MP0003186_abnormal_redox_activity2.45032056
11MP0001905_abnormal_dopamine_level2.40488075
12MP0008438_abnormal_cutaneous_collagen2.39544965
13MP0006276_abnormal_autonomic_nervous2.35110261
14MP0000920_abnormal_myelination2.24792081
15MP0002837_dystrophic_cardiac_calcinosis2.15712396
16MP0005058_abnormal_lysosome_morphology2.14758119
17MP0000750_abnormal_muscle_regeneration2.14080608
18MP0002876_abnormal_thyroid_physiology2.00847559
19MP0002822_catalepsy1.99280162
20MP0005410_abnormal_fertilization1.96398580
21MP0004270_analgesia1.85394923
22MP0002064_seizures1.85134149
23MP0003195_calcinosis1.83082786
24MP0003329_amyloid_beta_deposits1.77383705
25MP0001968_abnormal_touch/_nociception1.76697994
26MP0001542_abnormal_bone_strength1.76560851
27MP0002295_abnormal_pulmonary_circulatio1.73560705
28MP0002736_abnormal_nociception_after1.71294425
29MP0003566_abnormal_cell_adhesion1.70302770
30MP0003122_maternal_imprinting1.70121820
31MP0009046_muscle_twitch1.68405178
32MP0000749_muscle_degeneration1.65426808
33MP0002272_abnormal_nervous_system1.63724015
34MP0002735_abnormal_chemical_nociception1.63234315
35MP0009745_abnormal_behavioral_response1.63189456
36MP0000343_altered_response_to1.62374983
37MP0002653_abnormal_ependyma_morphology1.60101271
38MP0002734_abnormal_mechanical_nocicepti1.58999995
39MP0003136_yellow_coat_color1.55636792
40MP0002733_abnormal_thermal_nociception1.54540241
41MP0005379_endocrine/exocrine_gland_phen1.51081296
42MP0001440_abnormal_grooming_behavior1.49177029
43MP0003690_abnormal_glial_cell1.47768099
44MP0004272_abnormal_basement_membrane1.46440452
45MP0002163_abnormal_gland_morphology1.45659318
46MP0001970_abnormal_pain_threshold1.44221289
47MP0008789_abnormal_olfactory_epithelium1.42774369
48MP0000751_myopathy1.42448354
49MP0003635_abnormal_synaptic_transmissio1.41370608
50MP0002572_abnormal_emotion/affect_behav1.41337198
51MP0009780_abnormal_chondrocyte_physiolo1.39783826
52MP0004233_abnormal_muscle_weight1.38447778
53MP0008260_abnormal_autophagy1.38040551
54MP0005508_abnormal_skeleton_morphology1.36870430
55MP0004043_abnormal_pH_regulation1.36221899
56MP0001501_abnormal_sleep_pattern1.35628766
57MP0000604_amyloidosis1.35311296
58MP0005171_absent_coat_pigmentation1.35246354
59MP0004142_abnormal_muscle_tone1.32872217
60MP0000538_abnormal_urinary_bladder1.32643049
61MP0001529_abnormal_vocalization1.32268031
62MP0005165_increased_susceptibility_to1.27876583
63MP0010368_abnormal_lymphatic_system1.27244129
64MP0003634_abnormal_glial_cell1.23327072
65MP0004742_abnormal_vestibular_system1.23316938
66MP0000762_abnormal_tongue_morphology1.22625821
67MP0002282_abnormal_trachea_morphology1.21668296
68MP0005084_abnormal_gallbladder_morpholo1.21078402
69MP0005503_abnormal_tendon_morphology1.21051474
70MP0000358_abnormal_cell_content/1.19152503
71MP0003786_premature_aging1.18898895
72MP0001986_abnormal_taste_sensitivity1.17776324
73MP0005584_abnormal_enzyme/coenzyme_acti1.16641598
74MP0003191_abnormal_cellular_cholesterol1.16338893
75MP0005408_hypopigmentation1.15142243
76MP0005394_taste/olfaction_phenotype1.13623547
77MP0005499_abnormal_olfactory_system1.13623547
78MP0000516_abnormal_urinary_system1.13542828
79MP0005367_renal/urinary_system_phenotyp1.13542828
80MP0005197_abnormal_uvea_morphology1.13316009
81MP0002332_abnormal_exercise_endurance1.13130860
82MP0000681_abnormal_thyroid_gland1.10927537
83MP0002063_abnormal_learning/memory/cond1.10528027
84MP0003724_increased_susceptibility_to1.10405825
85MP0000778_abnormal_nervous_system1.09191460
86MP0001727_abnormal_embryo_implantation1.08896214
87MP0006082_CNS_inflammation1.08626088
88MP0005023_abnormal_wound_healing1.08531872
89MP0009379_abnormal_foot_pigmentation1.08077556
90MP0005164_abnormal_response_to1.07755041
91MP0002090_abnormal_vision1.05659542
92MP0002067_abnormal_sensory_capabilities1.05312614
93MP0009384_cardiac_valve_regurgitation1.02837029
94MP0001486_abnormal_startle_reflex1.01613260
95MP0001243_abnormal_dermal_layer1.01339120
96MP0001299_abnormal_eye_distance/1.00632025
97MP0005332_abnormal_amino_acid0.99863147
98MP0003705_abnormal_hypodermis_morpholog0.99476193
99MP0005409_darkened_coat_color0.97781199
100MP0002896_abnormal_bone_mineralization0.96728009
101MP0003950_abnormal_plasma_membrane0.95626467
102MP0008004_abnormal_stomach_pH0.95563705
103MP0003011_delayed_dark_adaptation0.94674588
104MP0003075_altered_response_to0.94346536
105MP0000003_abnormal_adipose_tissue0.94188027
106MP0002102_abnormal_ear_morphology0.93346609
107MP0005645_abnormal_hypothalamus_physiol0.92020040
108MP0002638_abnormal_pupillary_reflex0.91868922
109MP0004859_abnormal_synaptic_plasticity0.91680406
110MP0000462_abnormal_digestive_system0.91660868
111MP0005595_abnormal_vascular_smooth0.90636720
112MP0002229_neurodegeneration0.89344094
113MP0004134_abnormal_chest_morphology0.88368525
114MP0004858_abnormal_nervous_system0.85038325
115MP0000230_abnormal_systemic_arterial0.84763772
116MP0003633_abnormal_nervous_system0.83111010
117MP0009250_abnormal_appendicular_skeleto0.82371893
118MP0005636_abnormal_mineral_homeostasis0.82144502
119MP0003172_abnormal_lysosome_physiology0.82108326
120MP0000372_irregular_coat_pigmentation0.82032581
121MP0005330_cardiomyopathy0.81485055
122MP0001958_emphysema0.81465719
123MP0001188_hyperpigmentation0.80523812
124MP0002060_abnormal_skin_morphology0.80404235
125MP0005551_abnormal_eye_electrophysiolog0.80116316
126MP0001533_abnormal_skeleton_physiology0.80116028
127MP0005623_abnormal_meninges_morphology0.79922130
128MP0006035_abnormal_mitochondrial_morpho0.79366742
129MP0002184_abnormal_innervation0.78913835
130MP0002066_abnormal_motor_capabilities/c0.78066683
131MP0003631_nervous_system_phenotype0.77695873
132MP0009697_abnormal_copulation0.77537876
133MP0005275_abnormal_skin_tensile0.77083828
134MP0002693_abnormal_pancreas_physiology0.76333048
135MP0008875_abnormal_xenobiotic_pharmacok0.75507810
136MP0001664_abnormal_digestion0.75283896
137MP0002177_abnormal_outer_ear0.74413559
138MP0005386_behavior/neurological_phenoty0.73813643
139MP0004924_abnormal_behavior0.73813643
140MP0003385_abnormal_body_wall0.73557409
141MP0002148_abnormal_hypersensitivity_rea0.73532052
142MP0004147_increased_porphyrin_level0.73136934
143MP0002557_abnormal_social/conspecific_i0.73134281
144MP0005193_abnormal_anterior_eye0.73108096
145MP0000163_abnormal_cartilage_morphology0.73069985
146MP0006036_abnormal_mitochondrial_physio0.72326034
147MP0004510_myositis0.71905304
148MP0001346_abnormal_lacrimal_gland0.71707075
149MP0003806_abnormal_nucleotide_metabolis0.71693812
150MP0000858_altered_metastatic_potential0.71164890
151MP0005166_decreased_susceptibility_to0.68129070
152MP0002938_white_spotting0.67923226
153MP0001879_abnormal_lymphatic_vessel0.67607339
154MP0009764_decreased_sensitivity_to0.66648994
155MP0003137_abnormal_impulse_conducting0.66202770
156MP0001984_abnormal_olfaction0.65835002
157MP0005390_skeleton_phenotype0.65815688
158MP0003755_abnormal_palate_morphology0.61008887
159MP0005365_abnormal_bile_salt0.59487100
160MP0003221_abnormal_cardiomyocyte_apopto0.57356316
161MP0000049_abnormal_middle_ear0.56981888
162MP0000534_abnormal_ureter_morphology0.55067110

Predicted human phenotypes

RankGene SetZ-score
1Acute necrotizing encephalopathy (HP:0006965)4.67215476
2Abnormal mitochondria in muscle tissue (HP:0008316)4.16770564
3Progressive macrocephaly (HP:0004481)3.93005881
4Acute encephalopathy (HP:0006846)3.82821293
5Congenital nonbullous ichthyosiform erythroderma (HP:0007479)3.62885926
6Mitochondrial inheritance (HP:0001427)3.55458595
7Pheochromocytoma (HP:0002666)3.53357346
8Neuroendocrine neoplasm (HP:0100634)3.46273630
9Hypothermia (HP:0002045)3.35786576
10Neurofibrillary tangles (HP:0002185)3.34624534
11Entropion (HP:0000621)3.31292762
12Hand muscle atrophy (HP:0009130)3.30983737
13Upper limb muscle weakness (HP:0003484)3.28112468
14Vacuolated lymphocytes (HP:0001922)3.23628220
15Distal upper limb amyotrophy (HP:0007149)2.89725032
16Upper limb amyotrophy (HP:0009129)2.89725032
17Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.89074524
18Increased neuronal autofluorescent lipopigment (HP:0002074)2.85166249
19Hypokinesia (HP:0002375)2.78627211
20Hepatocellular necrosis (HP:0001404)2.78082026
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.78079980
22Decreased activity of mitochondrial respiratory chain (HP:0008972)2.78079980
23Difficulty climbing stairs (HP:0003551)2.77749031
24Type II lissencephaly (HP:0007260)2.73993170
25Increased CSF lactate (HP:0002490)2.71539829
26Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.69486052
27Abnormal protein N-linked glycosylation (HP:0012347)2.69486052
28Abnormal protein glycosylation (HP:0012346)2.69486052
29Abnormal glycosylation (HP:0012345)2.69486052
30Abnormal gallbladder physiology (HP:0012438)2.63460612
31Cholecystitis (HP:0001082)2.63460612
32Methylmalonic acidemia (HP:0002912)2.61916622
33Sensory axonal neuropathy (HP:0003390)2.57983968
34Type I transferrin isoform profile (HP:0003642)2.57379877
35Cerebral edema (HP:0002181)2.53761371
36Short nail (HP:0001799)2.53382525
37Optic disc pallor (HP:0000543)2.52300766
38Abnormal pupillary function (HP:0007686)2.50961825
39Cerebral hemorrhage (HP:0001342)2.49926800
40Protrusio acetabuli (HP:0003179)2.49882340
41Generalized aminoaciduria (HP:0002909)2.49407803
42Cerebellar dysplasia (HP:0007033)2.49105369
43Increased cerebral lipofuscin (HP:0011813)2.48206476
44Premature rupture of membranes (HP:0001788)2.47633355
45Focal motor seizures (HP:0011153)2.47190392
46Ankle contracture (HP:0006466)2.46146286
47Cerebral inclusion bodies (HP:0100314)2.45079227
48Congenital ichthyosiform erythroderma (HP:0007431)2.43426035
49Leukodystrophy (HP:0002415)2.42604531
50Parakeratosis (HP:0001036)2.41907428
51Abnormality of glycolysis (HP:0004366)2.41658960
52Increased serum pyruvate (HP:0003542)2.41658960
53Hepatic necrosis (HP:0002605)2.41515781
54Atonic seizures (HP:0010819)2.40533882
55Autoamputation (HP:0001218)2.38959772
56Delusions (HP:0000746)2.38841253
57Renal Fanconi syndrome (HP:0001994)2.33429748
58Cerebral hypomyelination (HP:0006808)2.33000375
59Methylmalonic aciduria (HP:0012120)2.31446475
60Abnormality of aromatic amino acid family metabolism (HP:0004338)2.28092534
61Rough bone trabeculation (HP:0100670)2.28034783
62Decreased electroretinogram (ERG) amplitude (HP:0000654)2.26276045
63Cervical subluxation (HP:0003308)2.25375296
64Respiratory failure (HP:0002878)2.24279423
65Reduced antithrombin III activity (HP:0001976)2.22575257
66Atrophic scars (HP:0001075)2.21462680
67Follicular hyperkeratosis (HP:0007502)2.20775817
68Retinal dysplasia (HP:0007973)2.17456289
69Nuclear cataract (HP:0100018)2.17296069
70Mutism (HP:0002300)2.16229907
71Akinesia (HP:0002304)2.15616122
72Dysostosis multiplex (HP:0000943)2.14672171
73Emotional lability (HP:0000712)2.14457072
74Hyperventilation (HP:0002883)2.14010436
75Supranuclear gaze palsy (HP:0000605)2.09131878
76Congenital glaucoma (HP:0001087)2.08999057
77Polyphagia (HP:0002591)2.07293600
78Stridor (HP:0010307)2.05000165
79Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.02162311
80Degeneration of the lateral corticospinal tracts (HP:0002314)2.02162311
81Abnormal hair whorl (HP:0010721)2.01569853
82Epiphyseal dysplasia (HP:0002656)2.00796147
83X-linked dominant inheritance (HP:0001423)1.99606312
84Spinal rigidity (HP:0003306)1.97306089
85Medial flaring of the eyebrow (HP:0010747)1.94910118
86Hypoplasia of the pons (HP:0012110)1.94396429
87Retinal atrophy (HP:0001105)1.93867894
88Abnormal trabecular bone morphology (HP:0100671)1.93135198
89Buphthalmos (HP:0000557)1.89861844
90Secondary amenorrhea (HP:0000869)1.88245175
91CNS demyelination (HP:0007305)1.87699020
92Split foot (HP:0001839)1.87575789
93Esotropia (HP:0000565)1.87570744
94Thickened helices (HP:0000391)1.80519986
95Progressive microcephaly (HP:0000253)1.80419473
96Reduced subcutaneous adipose tissue (HP:0003758)1.78713950
97Cortical visual impairment (HP:0100704)1.78105360
98Increased serum lactate (HP:0002151)1.77786839
99Disproportionate short-trunk short stature (HP:0003521)1.77672574
100CNS hypomyelination (HP:0003429)1.77543898
101Fatigue (HP:0012378)1.77423915
102Agitation (HP:0000713)1.77293682
103Limb-girdle muscle atrophy (HP:0003797)1.76679319
104Craniofacial dystonia (HP:0012179)1.73715002
105Abnormality of dentin (HP:0010299)1.73614446
106Myoclonus (HP:0001336)1.73310999
107Vaginal atresia (HP:0000148)1.73272802
108Gait imbalance (HP:0002141)1.73146413
109Abnormality of renal resorption (HP:0011038)1.72663335
110Bladder diverticulum (HP:0000015)1.72158142
111Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.71960880
112Abnormal autonomic nervous system physiology (HP:0012332)1.71428083
113Redundant skin (HP:0001582)1.70863580
114Spastic paraparesis (HP:0002313)1.70829002
115Delayed gross motor development (HP:0002194)1.70300785
116Abnormal tarsal ossification (HP:0008369)1.69721963
117Limb dystonia (HP:0002451)1.69654417
118Symptomatic seizures (HP:0011145)1.69153740
119Poor suck (HP:0002033)1.69034666
120Amniotic constriction ring (HP:0009775)1.68933697
121Abnormality of placental membranes (HP:0011409)1.68933697
122Diminished movement (HP:0002374)1.68858915
123Exercise intolerance (HP:0003546)1.68385053
124Genital tract atresia (HP:0001827)1.68269269
125Metaphyseal dysplasia (HP:0100255)1.68053687
126Abnormality of liposaccharide metabolism (HP:0010968)1.67156992
127Abnormality of glycosphingolipid metabolism (HP:0004343)1.67156992
128Abnormality of glycolipid metabolism (HP:0010969)1.67156992
129Delayed CNS myelination (HP:0002188)1.65957904
130Congenital primary aphakia (HP:0007707)1.65716259
131Cardiovascular calcification (HP:0011915)1.65667782
132Adrenal hypoplasia (HP:0000835)1.65593634
133Severe muscular hypotonia (HP:0006829)1.65326914
134Opisthotonus (HP:0002179)1.64506218
135Dialeptic seizures (HP:0011146)1.63941316
136Vertebral compression fractures (HP:0002953)1.63669766
137Absence seizures (HP:0002121)1.61744722
138Epileptic encephalopathy (HP:0200134)1.61380149
139Axonal loss (HP:0003447)1.61368003
140Abnormality of the pons (HP:0007361)1.61008410
141Increased intramyocellular lipid droplets (HP:0012240)1.60587442
142Mitral stenosis (HP:0001718)1.59105693
143Insomnia (HP:0100785)1.58648254
144Progressive neurologic deterioration (HP:0002344)1.58097852
145Hyperalaninemia (HP:0003348)1.57327821
146Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.57327821
147Beaking of vertebral bodies (HP:0004568)1.57326721
148Clumsiness (HP:0002312)1.57079495
149Nephrogenic diabetes insipidus (HP:0009806)1.56283254
150Prolonged neonatal jaundice (HP:0006579)1.56161268
151Xerostomia (HP:0000217)1.56045110
152Increased hepatocellular lipid droplets (HP:0006565)1.55765485
153Infantile muscular hypotonia (HP:0008947)1.53925322
154Conjugated hyperbilirubinemia (HP:0002908)1.53795369
155Lactic acidosis (HP:0003128)1.52998214
156Thyroid-stimulating hormone excess (HP:0002925)1.52788096
157Abnormality of urine glucose concentration (HP:0011016)1.51668957
158Glycosuria (HP:0003076)1.51668957
159Congenital sensorineural hearing impairment (HP:0008527)1.51316338
160Myokymia (HP:0002411)1.51304122
1613-Methylglutaconic aciduria (HP:0003535)1.51136372
162Progressive inability to walk (HP:0002505)1.51128385
163Hypoglycemic seizures (HP:0002173)1.48438604

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.32742459
2BCKDK3.19695888
3MST42.93169692
4STK392.85441969
5TESK22.77479421
6OXSR12.52670111
7MAP3K122.41050858
8EPHB22.36250252
9MAP4K22.27973132
10NME12.21561066
11EPHA22.09829691
12ARAF2.07181459
13MYLK2.02933749
14BCR2.02048778
15WNK41.99961175
16DDR21.99040820
17LIMK11.92067368
18VRK21.86014054
19NTRK11.83648421
20STK101.77084619
21BMPR1B1.71764255
22EPHB11.61203977
23LMTK21.59218150
24PRPF4B1.57576830
25WNK31.52860614
26TRIM281.49983860
27AKT31.42035525
28CAMK2B1.39869707
29ADRBK21.38097276
30GRK71.37219437
31NTRK31.35920181
32ERBB41.32340766
33INSRR1.31696011
34BLK1.31568992
35PAK41.31031960
36PBK1.27934842
37CDK191.25936119
38PLK21.24664824
39TNIK1.22558008
40CAMK2D1.21183801
41GRK51.17547619
42NEK61.14692150
43BMPR21.13948612
44PAK31.13781363
45PRKCE1.13147419
46PAK61.11871380
47MAPKAPK51.10890929
48PIK3CA1.10260771
49MAPK151.09986553
50CAMK2A1.07283158
51MET1.05546259
52MAP3K111.01861369
53PIM20.99785591
54SRPK10.99270549
55CAMK2G0.97871005
56FER0.96986019
57CSNK1G30.96590937
58MAP2K70.96481359
59TBK10.95826710
60PIK3CG0.95614814
61STK160.95449676
62PTK2B0.93984629
63PKN10.93706190
64NEK10.93376750
65MAP3K30.91691990
66ROCK20.91386201
67SIK30.89690466
68BRAF0.89450235
69TAOK20.88920456
70AURKA0.88261359
71FGR0.82823523
72BUB10.82658510
73EPHA40.82599553
74DAPK10.82429973
75CAMKK20.82286197
76MAP2K10.82206857
77PRKD30.81863252
78MAPKAPK30.80979691
79PDK20.80759207
80ILK0.79637694
81WNK10.77321772
82TRPM70.76843310
83DAPK30.76425605
84SGK4940.74695682
85SGK2230.74695682
86EIF2AK30.73064394
87MAP3K20.71841283
88MAP3K40.70939978
89CSNK1G20.70367306
90FRK0.68790486
91PAK10.67264987
92OBSCN0.66770432
93ADRBK10.66639770
94TESK10.66525759
95FGFR20.66084998
96MARK10.64205893
97MINK10.63317637
98DYRK20.62700308
99ERN10.62379322
100PRKCI0.61762271
101EIF2AK10.60409749
102CDK50.59710104
103PRKCG0.59687484
104PTK20.59352254
105MAP2K20.58753640
106MAP3K50.58183799
107MUSK0.57873802
108MST1R0.57243449
109PRKD20.56961241
110FLT30.56779808
111NME20.56579993
112CSNK1A1L0.56405809
113FES0.56177849
114ABL20.54691630
115CSNK1G10.54451443
116DAPK20.54442339
117PRKG20.53400120
118GRK10.52337800
119KDR0.51438751
120TGFBR20.50922847
121MOS0.49312580
122PNCK0.49192995
123CDK180.47143591
124PINK10.46410432
125TLK10.46284990
126MAP3K90.46152397
127CDK11A0.45816002
128CDK140.45456109
129PRKACA0.43515297
130ROCK10.43452700
131FYN0.43104063
132BRSK10.42728195
133AKT20.42264823
134MAPK130.41984021
135PHKG10.41853700
136PHKG20.41853700
137CSK0.40997434
138ERBB30.40927037
139UHMK10.40729135
140IRAK30.40602475
141PAK20.40107995
142CDK150.39735728
143GSK3A0.39585822
144PRKCQ0.39195244
145TAOK10.38426186
146CSNK1A10.37880774
147MAP2K40.37406382
148CCNB10.35326811

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030604.05458520
2Oxidative phosphorylation_Homo sapiens_hsa001903.96399549
3Collecting duct acid secretion_Homo sapiens_hsa049663.26077231
4Vibrio cholerae infection_Homo sapiens_hsa051103.01995584
5Sulfur relay system_Homo sapiens_hsa041222.75476696
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.71737914
7Parkinsons disease_Homo sapiens_hsa050122.70247011
8Sulfur metabolism_Homo sapiens_hsa009202.49130769
9Alzheimers disease_Homo sapiens_hsa050102.37818016
10Fatty acid elongation_Homo sapiens_hsa000622.22515415
11Rheumatoid arthritis_Homo sapiens_hsa053232.21544946
122-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.12581606
13Steroid biosynthesis_Homo sapiens_hsa001002.11679061
14Synaptic vesicle cycle_Homo sapiens_hsa047212.01569152
15Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.87016902
16Phagosome_Homo sapiens_hsa041451.83054462
17SNARE interactions in vesicular transport_Homo sapiens_hsa041301.79301050
18Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.78078881
19Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71851761
20RNA polymerase_Homo sapiens_hsa030201.67558198
21Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.66317606
22Huntingtons disease_Homo sapiens_hsa050161.62911642
23Biosynthesis of amino acids_Homo sapiens_hsa012301.57753557
24Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.55786490
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.55339565
26Galactose metabolism_Homo sapiens_hsa000521.52229125
27Lysosome_Homo sapiens_hsa041421.51318577
28Sphingolipid metabolism_Homo sapiens_hsa006001.51032676
29Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.48471295
30Histidine metabolism_Homo sapiens_hsa003401.47389914
31Other glycan degradation_Homo sapiens_hsa005111.43053954
32Carbon metabolism_Homo sapiens_hsa012001.35908074
33Ether lipid metabolism_Homo sapiens_hsa005651.34104192
34Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.32267366
35Proteasome_Homo sapiens_hsa030501.30840450
36Serotonergic synapse_Homo sapiens_hsa047261.26701845
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.22643622
38Fructose and mannose metabolism_Homo sapiens_hsa000511.22419292
39Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.20268952
40Nicotine addiction_Homo sapiens_hsa050331.19971470
41Pyrimidine metabolism_Homo sapiens_hsa002401.15434243
42GABAergic synapse_Homo sapiens_hsa047271.15122731
43Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.14364341
44Primary bile acid biosynthesis_Homo sapiens_hsa001201.12742782
45Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.11676230
46Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.11180371
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.10192843
48Pentose phosphate pathway_Homo sapiens_hsa000301.05751189
49Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.04632449
50Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03615516
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02159082
52Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.97750491
53Cardiac muscle contraction_Homo sapiens_hsa042600.96425247
54Butanoate metabolism_Homo sapiens_hsa006500.96113526
55Tyrosine metabolism_Homo sapiens_hsa003500.93916933
56Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.93350891
57Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.93009121
58Taste transduction_Homo sapiens_hsa047420.92428118
59Shigellosis_Homo sapiens_hsa051310.90866526
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.90322968
61Phenylalanine metabolism_Homo sapiens_hsa003600.88896290
62Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.87764995
63Morphine addiction_Homo sapiens_hsa050320.85524246
64Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.77894576
65* Cocaine addiction_Homo sapiens_hsa050300.76801365
66Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.76728381
67Arachidonic acid metabolism_Homo sapiens_hsa005900.75431143
68Arginine and proline metabolism_Homo sapiens_hsa003300.74144393
69Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.71246155
70Peroxisome_Homo sapiens_hsa041460.70122968
71* Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.70118752
72Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.69396991
73* Insulin secretion_Homo sapiens_hsa049110.68109341
74Linoleic acid metabolism_Homo sapiens_hsa005910.67112111
75Autoimmune thyroid disease_Homo sapiens_hsa053200.66977181
76Axon guidance_Homo sapiens_hsa043600.64096415
77Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.63618514
78Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.63057033
79Base excision repair_Homo sapiens_hsa034100.63038501
80Prion diseases_Homo sapiens_hsa050200.62851527
81* Dopaminergic synapse_Homo sapiens_hsa047280.62041050
82Vitamin digestion and absorption_Homo sapiens_hsa049770.61543734
83Circadian entrainment_Homo sapiens_hsa047130.59884400
84Endocytosis_Homo sapiens_hsa041440.59311525
85Folate biosynthesis_Homo sapiens_hsa007900.58983129
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.58590473
87Type I diabetes mellitus_Homo sapiens_hsa049400.58113936
88Legionellosis_Homo sapiens_hsa051340.57768136
89Purine metabolism_Homo sapiens_hsa002300.57472642
90Metabolic pathways_Homo sapiens_hsa011000.57194444
91Long-term depression_Homo sapiens_hsa047300.56941605
92Mineral absorption_Homo sapiens_hsa049780.56657406
93Pyruvate metabolism_Homo sapiens_hsa006200.54758018
94Glutamatergic synapse_Homo sapiens_hsa047240.54756039
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.54525364
96Vascular smooth muscle contraction_Homo sapiens_hsa042700.53737647
97alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.52362591
98N-Glycan biosynthesis_Homo sapiens_hsa005100.52325389
99Chemical carcinogenesis_Homo sapiens_hsa052040.51543915
100Glutathione metabolism_Homo sapiens_hsa004800.51215241
101Regulation of autophagy_Homo sapiens_hsa041400.50029753
102Complement and coagulation cascades_Homo sapiens_hsa046100.48376305
103ECM-receptor interaction_Homo sapiens_hsa045120.48074991
104Malaria_Homo sapiens_hsa051440.47986213
105* Amphetamine addiction_Homo sapiens_hsa050310.47533944
106Fatty acid metabolism_Homo sapiens_hsa012120.47110735
107Propanoate metabolism_Homo sapiens_hsa006400.46962677
108beta-Alanine metabolism_Homo sapiens_hsa004100.45945351
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.45747619
110Pancreatic secretion_Homo sapiens_hsa049720.45463998
111Nucleotide excision repair_Homo sapiens_hsa034200.45311462
112Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43921035
113Pertussis_Homo sapiens_hsa051330.43764083
114Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.43094857
115Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42077957
116* Cholinergic synapse_Homo sapiens_hsa047250.40837553
117Vitamin B6 metabolism_Homo sapiens_hsa007500.39584699
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.37135710
119Graft-versus-host disease_Homo sapiens_hsa053320.36162994
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.35350771
121Cyanoamino acid metabolism_Homo sapiens_hsa004600.32843384
122PPAR signaling pathway_Homo sapiens_hsa033200.31828605
123Tryptophan metabolism_Homo sapiens_hsa003800.31490773
124Arginine biosynthesis_Homo sapiens_hsa002200.31347698
125Basal transcription factors_Homo sapiens_hsa030220.30914278
126Phototransduction_Homo sapiens_hsa047440.30848312
127Salmonella infection_Homo sapiens_hsa051320.30378959
128Renin secretion_Homo sapiens_hsa049240.30073569
129Renin-angiotensin system_Homo sapiens_hsa046140.29393199
130Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.29095976
131Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.28879394
132* Thyroid hormone synthesis_Homo sapiens_hsa049180.27986594
133Ovarian steroidogenesis_Homo sapiens_hsa049130.27180120
134Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.26583913
135Protein digestion and absorption_Homo sapiens_hsa049740.26164757
136Glycosaminoglycan degradation_Homo sapiens_hsa005310.26093401
137Focal adhesion_Homo sapiens_hsa045100.25325006
138Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.25076180
139Salivary secretion_Homo sapiens_hsa049700.24959356
140Drug metabolism - other enzymes_Homo sapiens_hsa009830.24458681
141Selenocompound metabolism_Homo sapiens_hsa004500.24287901
142Fatty acid degradation_Homo sapiens_hsa000710.23135909

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