CREB3L4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a CREB (cAMP responsive element binding) protein with a transmembrane domain which localizes it to the ER membrane. The encoded protein is a transcriptional activator which contains a dimerization domain, and this protein may function in a number of processing pathways including protein processing. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1multicellular organism reproduction (GO:0032504)9.87024694
2sperm-egg recognition (GO:0035036)9.63710625
3acrosome assembly (GO:0001675)9.34941458
4binding of sperm to zona pellucida (GO:0007339)8.86727631
5acrosome reaction (GO:0007340)8.81522973
6cell-cell recognition (GO:0009988)8.55697742
7piRNA metabolic process (GO:0034587)8.35864155
8axonemal dynein complex assembly (GO:0070286)8.16680579
9plasma membrane fusion (GO:0045026)8.11105909
10reproduction (GO:0000003)8.10543643
11male meiosis (GO:0007140)8.09228016
12epithelial cilium movement (GO:0003351)7.84104373
13spermatid development (GO:0007286)7.70510769
14cilium or flagellum-dependent cell motility (GO:0001539)7.61187190
15motile cilium assembly (GO:0044458)7.39891267
16synaptonemal complex assembly (GO:0007130)6.90329124
17synaptonemal complex organization (GO:0070193)6.81064746
18cilium movement (GO:0003341)6.76720201
19regulation of cilium movement (GO:0003352)6.76540273
20single fertilization (GO:0007338)6.61043320
21microtubule depolymerization (GO:0007019)5.88310641
22fertilization (GO:0009566)5.87702630
23epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.80994024
24* spermatogenesis (GO:0007283)5.78702516
25* male gamete generation (GO:0048232)5.77516888
26sperm capacitation (GO:0048240)5.70997899
27intestinal epithelial cell development (GO:0060576)5.60788487
28microtubule severing (GO:0051013)5.55891527
29* gamete generation (GO:0007276)5.54260879
30DNA methylation involved in gamete generation (GO:0043046)5.51708127
31male meiosis I (GO:0007141)5.23620633
32negative regulation of inclusion body assembly (GO:0090084)5.18394542
33meiotic cell cycle (GO:0051321)5.00671845
34monoubiquitinated protein deubiquitination (GO:0035520)4.96526856
35meiotic nuclear division (GO:0007126)4.93528657
36organic cation transport (GO:0015695)4.80503733
37chromosome condensation (GO:0030261)4.79338560
38epithelial cell maturation (GO:0002070)4.76565273
39cellular process involved in reproduction in multicellular organism (GO:0022412)4.76165277
40chromosome organization involved in meiosis (GO:0070192)4.74707008
41germ cell development (GO:0007281)4.58536488
42biotin metabolic process (GO:0006768)4.50958864
43meiosis I (GO:0007127)4.48753481
44DNA packaging (GO:0006323)4.46343160
45prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060524.42226685
46regulation of inclusion body assembly (GO:0090083)4.41082563
47* multicellular organismal reproductive process (GO:0048609)4.34386079
48proline biosynthetic process (GO:0006561)4.19568224
49seminiferous tubule development (GO:0072520)4.01697821
50ventricular system development (GO:0021591)3.98881529
51regulation of meiosis I (GO:0060631)3.98643024
52protein polyglutamylation (GO:0018095)3.95996491
53base-excision repair, AP site formation (GO:0006285)3.92246647
54cell recognition (GO:0008037)3.89416902
55negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.87499433
56regulation of spindle checkpoint (GO:0090231)3.80613846
57regulation of microtubule-based movement (GO:0060632)3.74825708
58mitotic sister chromatid cohesion (GO:0007064)3.74396289
59meiotic cell cycle process (GO:1903046)3.70088127
60spermatid nucleus differentiation (GO:0007289)3.67997040
61calcium ion-dependent exocytosis (GO:0017156)3.67091863
62GDP-mannose metabolic process (GO:0019673)3.65711761
63ear development (GO:0043583)3.64279762
64pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.60147000
65amyloid precursor protein catabolic process (GO:0042987)3.58388636
66gene silencing by RNA (GO:0031047)3.51825725
67histone exchange (GO:0043486)3.51518131
68purine nucleotide transport (GO:0015865)3.51362772
69protein localization to chromosome, centromeric region (GO:0071459)3.49636694
70purine ribonucleotide transport (GO:0015868)3.48542740
71regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.48374973
72single strand break repair (GO:0000012)3.44442696
73uterus development (GO:0060065)3.43069893
74rRNA modification (GO:0000154)3.40466176
75multicellular organismal development (GO:0007275)3.39817604
76oocyte maturation (GO:0001556)3.38040460
77glycerol ether metabolic process (GO:0006662)3.37122427
78positive regulation of keratinocyte differentiation (GO:0045618)3.35747497
79microtubule polymerization or depolymerization (GO:0031109)3.33565355
80branching involved in prostate gland morphogenesis (GO:0060442)3.32350443
81ribosomal small subunit assembly (GO:0000028)3.29311157
82centriole replication (GO:0007099)3.26893943
83negative regulation of cell fate commitment (GO:0010454)3.23822782
84regulation of centriole replication (GO:0046599)3.23054369
85mitotic metaphase plate congression (GO:0007080)3.21675209
86centriole assembly (GO:0098534)3.14231572
87nucleus organization (GO:0006997)3.12434704
88female gamete generation (GO:0007292)3.12076068
89regulation of branching involved in prostate gland morphogenesis (GO:0060687)3.11961704
90ether metabolic process (GO:0018904)3.08158109
91left/right pattern formation (GO:0060972)3.07981298
92rRNA methylation (GO:0031167)3.07402094
93pyrimidine nucleotide catabolic process (GO:0006244)3.06645290
94interferon-gamma secretion (GO:0072643)3.06328548
95genitalia morphogenesis (GO:0035112)3.05875532
96meiotic chromosome segregation (GO:0045132)3.05046076
97protein K6-linked ubiquitination (GO:0085020)3.04535702
98regulation of retinoic acid receptor signaling pathway (GO:0048385)3.03399864
99ribosomal small subunit biogenesis (GO:0042274)3.03372184
100sister chromatid cohesion (GO:0007062)2.97301442
101proline metabolic process (GO:0006560)2.94635250
102protein complex localization (GO:0031503)2.94415229
103regulation of meiosis (GO:0040020)2.92174997
104adenine nucleotide transport (GO:0051503)2.91800822
105female gonad development (GO:0008585)2.91384919
106DNA damage response, signal transduction resulting in transcription (GO:0042772)2.81675995
107DNA alkylation (GO:0006305)2.81458127
108DNA methylation (GO:0006306)2.81458127
109nuclear pore complex assembly (GO:0051292)2.81133141
110regulation of water loss via skin (GO:0033561)2.81105055
111branched-chain amino acid catabolic process (GO:0009083)2.80992014
112intraciliary transport (GO:0042073)2.78920325
113mitotic sister chromatid segregation (GO:0000070)2.78142445
114mitotic chromosome condensation (GO:0007076)2.77364631
115regulation of acrosome reaction (GO:0060046)2.74865590
116prostate gland growth (GO:0060736)2.74795100
117attachment of spindle microtubules to kinetochore (GO:0008608)2.74073565
118viral transcription (GO:0019083)2.73258126
119vagina development (GO:0060068)2.73222420
120short-chain fatty acid metabolic process (GO:0046459)2.73188773
121gene silencing (GO:0016458)2.73022503
122negative regulation of transcription by competitive promoter binding (GO:0010944)2.72273629
123RNA destabilization (GO:0050779)2.70541536
124regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.70521393
125metaphase plate congression (GO:0051310)2.70352124
126regulation of chromosome segregation (GO:0051983)2.69633004
127cilium organization (GO:0044782)2.69560270
128maturation of SSU-rRNA (GO:0030490)2.69529439
129regulation of female gonad development (GO:2000194)2.69252932
130cardiac right ventricle morphogenesis (GO:0003215)2.68553818
131Golgi transport vesicle coating (GO:0048200)2.68312161
132COPI coating of Golgi vesicle (GO:0048205)2.68312161
133glutathione biosynthetic process (GO:0006750)2.67958329
134positive regulation of epidermal cell differentiation (GO:0045606)2.67146476
135translational termination (GO:0006415)2.67139628
136nucleotide transmembrane transport (GO:1901679)2.66621095
137lung secretory cell differentiation (GO:0061140)2.64930489
138vitamin transmembrane transport (GO:0035461)2.64646488
139nonribosomal peptide biosynthetic process (GO:0019184)2.60078603
140base-excision repair (GO:0006284)2.59884650
141translational elongation (GO:0006414)2.58454091
142establishment of apical/basal cell polarity (GO:0035089)2.56710180
143tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.55817094
144RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.55817094
145nucleotide transport (GO:0006862)2.55589914
146glandular epithelial cell differentiation (GO:0002067)2.54920280
147L-serine metabolic process (GO:0006563)2.52248097
148prostate gland epithelium morphogenesis (GO:0060740)2.51892838
149SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.51713895
150phosphate ion homeostasis (GO:0055062)2.51702906
151trivalent inorganic anion homeostasis (GO:0072506)2.51702906
152pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.51577644
153cotranslational protein targeting to membrane (GO:0006613)2.50356413
154DNA replication checkpoint (GO:0000076)2.49209602
155keratinocyte development (GO:0003334)2.46089258
156protein targeting to ER (GO:0045047)2.44998534
157positive regulation of cellular amine metabolic process (GO:0033240)2.44722571
158female genitalia development (GO:0030540)2.44670374
159nucleotide-sugar biosynthetic process (GO:0009226)2.44196209
160regulation of translational fidelity (GO:0006450)2.43142634
161folic acid metabolic process (GO:0046655)2.42441221
162nucleoside transport (GO:0015858)2.41435213
163primary alcohol catabolic process (GO:0034310)2.40217677
164deoxyribose phosphate catabolic process (GO:0046386)2.39426269
165nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.39334136
166deoxyribonucleotide catabolic process (GO:0009264)2.37697740
167translational initiation (GO:0006413)2.37633623
168negative regulation of mRNA metabolic process (GO:1903312)2.36627204
169exocrine pancreas development (GO:0031017)2.36376473
170serine family amino acid biosynthetic process (GO:0009070)2.36338078
171dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.36089475
172GPI anchor biosynthetic process (GO:0006506)2.35290291
173calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules (GO:0016338)2.34493600
174pharyngeal system development (GO:0060037)2.34393843
175ubiquinone biosynthetic process (GO:0006744)2.34007248
176establishment of protein localization to endoplasmic reticulum (GO:0072599)2.33522867
177pseudouridine synthesis (GO:0001522)2.33383732
178protein localization to endoplasmic reticulum (GO:0070972)2.32388679
179intracellular estrogen receptor signaling pathway (GO:0030520)2.31825094
180ribonucleoprotein complex biogenesis (GO:0022613)2.30703198
181nucleoside transmembrane transport (GO:1901642)2.29481100
182mammary gland epithelial cell differentiation (GO:0060644)2.28591569
183establishment or maintenance of monopolar cell polarity (GO:0061339)2.28447051
184establishment of monopolar cell polarity (GO:0061162)2.28447051
185negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 2.28337856
186ribosome biogenesis (GO:0042254)2.27747212
187viral life cycle (GO:0019058)2.27309963
188mRNA cleavage (GO:0006379)2.27253276
189regulation of mitochondrial translation (GO:0070129)2.26367036
190regulation of fatty acid beta-oxidation (GO:0031998)2.25493884
191regulation of cell proliferation involved in kidney development (GO:1901722)2.24182126
192formation of translation preinitiation complex (GO:0001731)2.24136364
193pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.22073130
194coenzyme A metabolic process (GO:0015936)2.21159297
195fusion of sperm to egg plasma membrane (GO:0007342)10.8379850
196cell wall macromolecule catabolic process (GO:0016998)10.3499186
197cell wall macromolecule metabolic process (GO:0044036)10.3499186
198sperm motility (GO:0030317)10.0361004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse8.57713540
2TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.63538940
3ESR1_20079471_ChIP-ChIP_T-47D_Human3.99171983
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.33815933
5E2F7_22180533_ChIP-Seq_HELA_Human3.13375875
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.10724961
7EZH2_22144423_ChIP-Seq_EOC_Human3.05999999
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.03344741
9ESR1_15608294_ChIP-ChIP_MCF-7_Human2.99287002
10MYC_18555785_ChIP-Seq_MESCs_Mouse2.95780013
11KAP1_22055183_ChIP-Seq_ESCs_Mouse2.93581918
12ESR1_21235772_ChIP-Seq_MCF-7_Human2.85334996
13STAT6_21828071_ChIP-Seq_BEAS2B_Human2.85193268
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.73365972
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.72584464
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.68475095
17KDM5A_27292631_Chip-Seq_BREAST_Human2.60150379
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.60113380
19FOXM1_23109430_ChIP-Seq_U2OS_Human2.57924209
20GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.54435034
21GATA1_26923725_Chip-Seq_HPCs_Mouse2.54358704
22FLI1_27457419_Chip-Seq_LIVER_Mouse2.49065832
23ZNF263_19887448_ChIP-Seq_K562_Human2.48439751
24NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.44013200
25ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.40820712
26XRN2_22483619_ChIP-Seq_HELA_Human2.39153402
27GABP_17652178_ChIP-ChIP_JURKAT_Human2.37299972
28MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28330043
29CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.23443685
30PCGF2_27294783_Chip-Seq_ESCs_Mouse2.20758749
31ETS1_20019798_ChIP-Seq_JURKAT_Human2.19888039
32MYC_19030024_ChIP-ChIP_MESCs_Mouse2.08990301
33EST1_17652178_ChIP-ChIP_JURKAT_Human2.08594996
34CREB1_15753290_ChIP-ChIP_HEK293T_Human2.05461484
35MYC_19079543_ChIP-ChIP_MESCs_Mouse2.00838475
36GABP_19822575_ChIP-Seq_HepG2_Human2.00412937
37DCP1A_22483619_ChIP-Seq_HELA_Human1.95568117
38ELF1_17652178_ChIP-ChIP_JURKAT_Human1.94967588
39PADI4_21655091_ChIP-ChIP_MCF-7_Human1.94633205
40STAT1_17558387_ChIP-Seq_HELA_Human1.94316383
41CHD1_26751641_Chip-Seq_LNCaP_Human1.92670284
42* MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.92162429
43EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.87554734
44ELK4_26923725_Chip-Seq_MESODERM_Mouse1.84699048
45VDR_22108803_ChIP-Seq_LS180_Human1.83856374
46CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83637906
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.83021010
48* RACK7_27058665_Chip-Seq_MCF-7_Human1.82997014
49ELF5_23300383_ChIP-Seq_T47D_Human1.82871570
50* KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.82151104
51MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.80367478
52HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.78236563
53RUNX1_27514584_Chip-Seq_MCF-7_Human1.73892891
54ZFX_18555785_ChIP-Seq_MESCs_Mouse1.72183219
55FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.70886449
56GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.70631522
57NELFA_20434984_ChIP-Seq_ESCs_Mouse1.70528546
58FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.69986832
59TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.68833522
60RUNX1_26923725_Chip-Seq_HPCs_Mouse1.68726129
61E2F1_18555785_ChIP-Seq_MESCs_Mouse1.67702306
62TTF2_22483619_ChIP-Seq_HELA_Human1.64045727
63FOXP3_21729870_ChIP-Seq_TREG_Human1.63105369
64RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62563336
65CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62191254
66* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.61204798
67MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60331838
68E2F1_21310950_ChIP-Seq_MCF-7_Human1.58590355
69BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.58444162
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.55551682
71PKCTHETA_26484144_Chip-Seq_BREAST_Human1.55122603
72NFE2_27457419_Chip-Seq_LIVER_Mouse1.54622530
73EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.54307667
74THAP11_20581084_ChIP-Seq_MESCs_Mouse1.53722812
75TAL1_26923725_Chip-Seq_HPCs_Mouse1.50694800
76TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.49585010
77PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.49182665
78GATA3_24758297_ChIP-Seq_MCF-7_Human1.48802485
79CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.48230429
80VDR_23849224_ChIP-Seq_CD4+_Human1.46235142
81CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.45955354
82RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.44959121
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.44239747
84WDR5_24793694_ChIP-Seq_LNCAP_Human1.44196138
85GATA3_21867929_ChIP-Seq_CD8_Mouse1.43361941
86SOX2_22085726_ChIP-Seq_NPCs_Mouse1.43186671
87AR_21909140_ChIP-Seq_LNCAP_Human1.43063728
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.39768889
89TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.39476111
90SALL1_21062744_ChIP-ChIP_HESCs_Human1.38980680
91KDM2B_26808549_Chip-Seq_REH_Human1.38818503
92RNF2_27304074_Chip-Seq_NSC_Mouse1.38597540
93TP63_19390658_ChIP-ChIP_HaCaT_Human1.38405849
94GATA3_21867929_ChIP-Seq_TH1_Mouse1.38249941
95POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37255611
96TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37255611
97* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.37171489
98HIF1A_21447827_ChIP-Seq_MCF-7_Human1.36765367
99POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.35082084
100ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.34701036
101E2F4_17652178_ChIP-ChIP_JURKAT_Human1.34072886
102SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33432501
103CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.32673978
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.31838269
105NANOG_18555785_Chip-Seq_ESCs_Mouse1.31648270
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.30850507
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.30683666
108SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.29995546
109MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.29695786
110CBX2_27304074_Chip-Seq_ESCs_Mouse1.29042003
111CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.27076206
112GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.26675441
113SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.26347156
114PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25560883
115FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.25253649
116ERG_20517297_ChIP-Seq_VCAP_Human1.25238248
117* FOXP1_21924763_ChIP-Seq_HESCs_Human1.23828174
118YY1_21170310_ChIP-Seq_MESCs_Mouse1.21825704
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.21643871
120MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.21487009
121CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.20995837
122* FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human1.20511738
123GF1_26923725_Chip-Seq_HPCs_Mouse1.20441207
124FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.20249101
125FLI1_21867929_ChIP-Seq_TH2_Mouse1.18727826
126PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.17400930
127CIITA_25753668_ChIP-Seq_RAJI_Human1.16480443
128DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.16358487
129CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.15739966
130EZH2_27294783_Chip-Seq_NPCs_Mouse1.15731446
131CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse1.15729564
132IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.15594896
133CBP_20019798_ChIP-Seq_JUKART_Human1.15594896
134ERG_20887958_ChIP-Seq_HPC-7_Mouse1.15327319
135OCT4_18555785_Chip-Seq_ESCs_Mouse1.13633452
136FUS_26573619_Chip-Seq_HEK293_Human1.13347847
137CRX_20693478_ChIP-Seq_RETINA_Mouse1.13249110
138HOXB4_20404135_ChIP-ChIP_EML_Mouse1.12512937
139CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12137402
140CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12032248
141CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.11368196
142GATA6_25053715_ChIP-Seq_YYC3_Human1.10513741
143KLF4_18555785_Chip-Seq_ESCs_Mouse1.10299718
144EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.09694514
145NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.08992548
146CREB1_26743006_Chip-Seq_LNCaP_Human1.08486729
147LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08004029
148SPI1_26923725_Chip-Seq_HPCs_Mouse1.07921270
149P53_21459846_ChIP-Seq_SAOS-2_Human1.07297170
150EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.07106328
151LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.06053506
152CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.05422129
153KLF4_18555785_ChIP-Seq_MESCs_Mouse1.04839430
154STAT3_18555785_ChIP-Seq_MESCs_Mouse1.03962900
155GF1B_26923725_Chip-Seq_HPCs_Mouse1.03460644
156CMYC_18555785_Chip-Seq_ESCs_Mouse1.03083972
157ESET_19884257_ChIP-Seq_ESCs_Mouse1.03043242
158LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02337050
159ESRRB_18555785_Chip-Seq_ESCs_Mouse1.02279289
160NANOG_18555785_ChIP-Seq_MESCs_Mouse1.02226328
161P53_22387025_ChIP-Seq_ESCs_Mouse1.01882007
162EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.00431987
163HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.00116686
164RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99817075
165STAT3_18555785_Chip-Seq_ESCs_Mouse0.99260787
166ELK1_19687146_ChIP-ChIP_HELA_Human0.99175031
167P68_20966046_ChIP-Seq_HELA_Human0.97847681
168PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.97811985
169TET1_21451524_ChIP-Seq_MESCs_Mouse0.97768422
170SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.97197084
171ZNF274_21170338_ChIP-Seq_K562_Hela0.96987010
172RARB_24833708_ChIP-Seq_LIVER_Mouse0.96831960
173ZFP57_27257070_Chip-Seq_ESCs_Mouse0.96711996
174PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.96384396
175OCT4_21477851_ChIP-Seq_ESCs_Mouse0.96094593
176SOX2_18555785_Chip-Seq_ESCs_Mouse0.95678265
177CDX2_22108803_ChIP-Seq_LS180_Human0.95414739
178VDR_21846776_ChIP-Seq_THP-1_Human0.94532583
179SUZ12_18555785_Chip-Seq_ESCs_Mouse0.93505353
180NANOG_20526341_ChIP-Seq_ESCs_Human0.92890915
181TBL1_22424771_ChIP-Seq_293T_Human0.92699668
182P300_18555785_Chip-Seq_ESCs_Mouse0.92577631
183CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92552740
184CTCF_18555785_Chip-Seq_ESCs_Mouse0.92133988
185TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.91181063
186CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.90346731
187FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.90320782
188SOX2_27498859_Chip-Seq_STOMACH_Mouse0.89579754
189PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.88836627
190EP300_21415370_ChIP-Seq_HL-1_Mouse0.88532907
191ZFX_18555785_Chip-Seq_ESCs_Mouse0.88520199
192PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87871170
193NMYC_18555785_Chip-Seq_ESCs_Mouse0.87327014

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0001929_abnormal_gametogenesis5.03187556
2MP0008877_abnormal_DNA_methylation4.99487162
3MP0003698_abnormal_male_reproductive4.87985897
4MP0002653_abnormal_ependyma_morphology4.10729388
5MP0002210_abnormal_sex_determination3.55046649
6MP0003646_muscle_fatigue3.11616070
7MP0002161_abnormal_fertility/fecundity3.04260221
8MP0002102_abnormal_ear_morphology3.01392911
9* MP0000653_abnormal_sex_gland2.90474222
10* MP0001145_abnormal_male_reproductive2.87638717
11MP0001873_stomach_inflammation2.78673718
12MP0003718_maternal_effect2.41335410
13MP0005451_abnormal_body_composition2.36332048
14MP0000537_abnormal_urethra_morphology2.32815840
15MP0003693_abnormal_embryo_hatching2.27425139
16MP0004782_abnormal_surfactant_physiolog2.25076478
17MP0010094_abnormal_chromosome_stability2.18233235
18MP0002796_impaired_skin_barrier2.16839043
19MP0002009_preneoplasia2.06310048
20MP0002736_abnormal_nociception_after2.02482557
21MP0005410_abnormal_fertilization11.9237681
22MP0003941_abnormal_skin_development1.90811981
23MP0005083_abnormal_biliary_tract1.89512807
24MP0003111_abnormal_nucleus_morphology1.87853084
25MP0001346_abnormal_lacrimal_gland1.87629822
26MP0002098_abnormal_vibrissa_morphology1.83001095
27MP0009780_abnormal_chondrocyte_physiolo1.80212247
28MP0002160_abnormal_reproductive_system1.80091532
29MP0010234_abnormal_vibrissa_follicle1.79844202
30MP0000627_abnormal_mammary_gland1.77421155
31MP0000538_abnormal_urinary_bladder1.74539992
32MP0001727_abnormal_embryo_implantation1.70579557
33MP0003787_abnormal_imprinting1.65450052
34MP0001881_abnormal_mammary_gland1.64095964
35MP0002822_catalepsy1.60702290
36MP0000383_abnormal_hair_follicle1.60173772
37MP0003077_abnormal_cell_cycle1.58881368
38MP0003699_abnormal_female_reproductive1.57280479
39MP0001119_abnormal_female_reproductive1.55415648
40MP0002166_altered_tumor_susceptibility1.54366959
41MP0005670_abnormal_white_adipose1.52814452
42MP0000462_abnormal_digestive_system1.52756649
43MP0005220_abnormal_exocrine_pancreas1.48757555
44MP0009672_abnormal_birth_weight1.47547297
45MP0002277_abnormal_respiratory_mucosa1.45546211
46MP0008058_abnormal_DNA_repair1.44760113
47MP0009384_cardiac_valve_regurgitation1.40667272
48MP0004185_abnormal_adipocyte_glucose1.40305409
49MP0004957_abnormal_blastocyst_morpholog1.36060299
50MP0005501_abnormal_skin_physiology1.34401928
51MP0004233_abnormal_muscle_weight1.33484479
52MP0010678_abnormal_skin_adnexa1.30411192
53MP0005389_reproductive_system_phenotype1.27881758
54MP0000566_synostosis1.25792802
55MP0005645_abnormal_hypothalamus_physiol1.22235519
56MP0000470_abnormal_stomach_morphology1.19969585
57MP0002282_abnormal_trachea_morphology1.19000471
58MP0004381_abnormal_hair_follicle1.18497055
59MP0002751_abnormal_autonomic_nervous1.17069353
60MP0008007_abnormal_cellular_replicative1.17066076
61MP0004264_abnormal_extraembryonic_tissu1.16773390
62MP0008875_abnormal_xenobiotic_pharmacok1.16167841
63MP0005075_abnormal_melanosome_morpholog1.13782126
64MP0002249_abnormal_larynx_morphology1.12829536
65MP0005395_other_phenotype1.11657015
66MP0003315_abnormal_perineum_morphology1.10109158
67MP0001764_abnormal_homeostasis1.08976697
68MP0005647_abnormal_sex_gland1.08307163
69MP0003937_abnormal_limbs/digits/tail_de1.08108824
70MP0000377_abnormal_hair_follicle1.06904083
71MP0002254_reproductive_system_inflammat1.05635840
72MP0003943_abnormal_hepatobiliary_system1.05089999
73MP0001968_abnormal_touch/_nociception1.02443982
74MP0003136_yellow_coat_color1.02438935
75MP0006035_abnormal_mitochondrial_morpho1.01546986
76MP0005310_abnormal_salivary_gland1.00122026
77MP0002006_tumorigenesis0.98551898
78MP0001730_embryonic_growth_arrest0.96863302
79MP0002938_white_spotting0.96095913
80MP0005076_abnormal_cell_differentiation0.92429062
81MP0009703_decreased_birth_body0.91768113
82MP0003123_paternal_imprinting0.90005014
83MP0004133_heterotaxia0.88387433
84MP0004858_abnormal_nervous_system0.88268335
85MP0001849_ear_inflammation0.87767336
86MP0005408_hypopigmentation0.86709958
87MP0000467_abnormal_esophagus_morphology0.85101755
88MP0002085_abnormal_embryonic_tissue0.85062913
89MP0001666_abnormal_nutrient_absorption0.83403633
90MP0005248_abnormal_Harderian_gland0.82974367
91MP0008789_abnormal_olfactory_epithelium0.82552033
92MP0001661_extended_life_span0.81711591
93MP0008872_abnormal_physiological_respon0.81637119
94MP0002084_abnormal_developmental_patter0.79503933
95MP0003183_abnormal_peptide_metabolism0.77988649
96MP0000358_abnormal_cell_content/0.77782159
97MP0003115_abnormal_respiratory_system0.77686707
98MP0008932_abnormal_embryonic_tissue0.76978341
99MP0001984_abnormal_olfaction0.75601534
100MP0001664_abnormal_digestion0.74774954
101MP0000579_abnormal_nail_morphology0.74460602
102MP0000350_abnormal_cell_proliferation0.72883937
103MP0005380_embryogenesis_phenotype0.72557674
104MP0001672_abnormal_embryogenesis/_devel0.72557674
105MP0001697_abnormal_embryo_size0.72352362
106MP0001765_abnormal_ion_homeostasis0.69908931
107MP0009250_abnormal_appendicular_skeleto0.69698800
108MP0003121_genomic_imprinting0.66114680
109MP0008995_early_reproductive_senescence0.65271288
110MP0000534_abnormal_ureter_morphology0.63075923
111MP0005623_abnormal_meninges_morphology0.62955419
112MP0000490_abnormal_crypts_of0.61194162
113MP0001919_abnormal_reproductive_system0.60601946
114MP0003786_premature_aging0.55450150
115MP0001529_abnormal_vocalization0.55272344
116MP0005499_abnormal_olfactory_system0.55090757
117MP0005394_taste/olfaction_phenotype0.55090757
118MP0000432_abnormal_head_morphology0.53548807
119MP0002233_abnormal_nose_morphology0.53260003
120MP0002234_abnormal_pharynx_morphology0.51721846
121MP0003861_abnormal_nervous_system0.51468402
122MP0003942_abnormal_urinary_system0.50974404
123MP0010030_abnormal_orbit_morphology0.50830804
124MP0010307_abnormal_tumor_latency0.49649445
125MP0003984_embryonic_growth_retardation0.49553587
126MP0000678_abnormal_parathyroid_gland0.49276682
127MP0001545_abnormal_hematopoietic_system0.49116545
128MP0005397_hematopoietic_system_phenotyp0.49116545
129MP0006072_abnormal_retinal_apoptosis0.49025986
130MP0006292_abnormal_olfactory_placode0.47250007
131MP0001485_abnormal_pinna_reflex0.46853911
132MP0005377_hearing/vestibular/ear_phenot0.46833560
133MP0003878_abnormal_ear_physiology0.46833560
134MP0000613_abnormal_salivary_gland0.45959797
135MP0002088_abnormal_embryonic_growth/wei0.45538357
136MP0002116_abnormal_craniofacial_bone0.45513638
137MP0008004_abnormal_stomach_pH0.45218507
138MP0003755_abnormal_palate_morphology0.45008363
139MP0008057_abnormal_DNA_replication0.44955558
140MP0003950_abnormal_plasma_membrane0.44526442
141MP0002019_abnormal_tumor_incidence0.44222750
142MP0002109_abnormal_limb_morphology0.41813402
143MP0005187_abnormal_penis_morphology0.41638789
144MP0000313_abnormal_cell_death0.41389367
145MP0010368_abnormal_lymphatic_system0.40960145
146MP0002932_abnormal_joint_morphology0.40768650
147MP0002928_abnormal_bile_duct0.40546768
148MP0009278_abnormal_bone_marrow0.40354790
149MP0002080_prenatal_lethality0.39357737
150MP0001915_intracranial_hemorrhage0.38518144
151MP0003936_abnormal_reproductive_system0.37972642
152MP0000427_abnormal_hair_cycle0.36698465
153MP0003011_delayed_dark_adaptation0.36130714
154MP0005646_abnormal_pituitary_gland0.33683607

Predicted human phenotypes

RankGene SetZ-score
1Abnormal respiratory motile cilium physiology (HP:0012261)8.48751926
2Chronic bronchitis (HP:0004469)7.22304568
3Male infertility (HP:0003251)7.20261862
4Abnormal respiratory motile cilium morphology (HP:0005938)6.89550261
5Abnormal respiratory epithelium morphology (HP:0012253)6.89550261
6Rhinitis (HP:0012384)6.84657587
7Infertility (HP:0000789)6.47615725
8Abnormal ciliary motility (HP:0012262)6.39822788
9Nasal polyposis (HP:0100582)4.93859657
10Nephronophthisis (HP:0000090)4.34171669
11Bronchiectasis (HP:0002110)4.28301525
12Testicular atrophy (HP:0000029)4.12992720
13Concave nail (HP:0001598)4.06702588
14Sparse lateral eyebrow (HP:0005338)3.96268267
15Abnormality of the nasal mucosa (HP:0000433)3.90536716
16Bronchitis (HP:0012387)3.89479106
17Abnormal spermatogenesis (HP:0008669)3.77625173
18Septate vagina (HP:0001153)3.49313118
19Breast carcinoma (HP:0003002)3.45243081
20Abnormality of the renal medulla (HP:0100957)3.34025652
21Hyperglycinuria (HP:0003108)3.22164563
22Abnormality of midbrain morphology (HP:0002418)3.05895295
23Molar tooth sign on MRI (HP:0002419)3.05895295
24Microretrognathia (HP:0000308)2.98169769
25Abnormality of the proximal phalanges of the hand (HP:0009834)2.94638977
26Abnormal number of erythroid precursors (HP:0012131)2.83268571
27Impulsivity (HP:0100710)2.82783457
28Azoospermia (HP:0000027)2.81909691
29Lip pit (HP:0100267)2.81140664
30Recurrent otitis media (HP:0000403)2.79466103
31Amelogenesis imperfecta (HP:0000705)2.69213002
32Germ cell neoplasia (HP:0100728)2.62695096
33Abnormal tarsal ossification (HP:0008369)2.62354946
34Abnormality of cells of the erythroid lineage (HP:0012130)2.59679272
35Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.54680350
36Short 1st metacarpal (HP:0010034)2.54680350
37Type I transferrin isoform profile (HP:0003642)2.54122329
38Papillary thyroid carcinoma (HP:0002895)2.51554905
39Tubulointerstitial nephritis (HP:0001970)2.47888601
40Medial flaring of the eyebrow (HP:0010747)2.45736917
41Tubular atrophy (HP:0000092)2.39314350
42Flat acetabular roof (HP:0003180)2.39018367
43Recurrent sinusitis (HP:0011108)2.38156380
44Abnormality of glycine metabolism (HP:0010895)2.34261243
45Abnormality of serine family amino acid metabolism (HP:0010894)2.34261243
46Microglossia (HP:0000171)2.32680949
47Abnormality of the 1st metacarpal (HP:0010009)2.32440909
48Cholecystitis (HP:0001082)2.29761597
49Abnormal gallbladder physiology (HP:0012438)2.29761597
50Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.27241438
51Abnormal protein N-linked glycosylation (HP:0012347)2.27241438
52Abnormal protein glycosylation (HP:0012346)2.27241438
53Abnormal glycosylation (HP:0012345)2.27241438
54Hypoparathyroidism (HP:0000829)2.25266450
55Pancreatic fibrosis (HP:0100732)2.24758090
56Hypoplasia of the pons (HP:0012110)2.22225654
57Tubulointerstitial abnormality (HP:0001969)2.18456297
58Pili torti (HP:0003777)2.18012223
59Curly hair (HP:0002212)2.16486170
60Abnormality of the pons (HP:0007361)2.12881512
61Postaxial foot polydactyly (HP:0001830)2.12792836
62Testicular neoplasm (HP:0010788)2.12187879
63Flat capital femoral epiphysis (HP:0003370)2.11304468
64Chromsome breakage (HP:0040012)2.10557612
65Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07143465
66Potter facies (HP:0002009)2.06732518
67Facial shape deformation (HP:0011334)2.06732518
68Thin bony cortex (HP:0002753)2.05058517
69Short thumb (HP:0009778)2.04198685
70Flattened epiphyses (HP:0003071)2.04025480
71Supernumerary spleens (HP:0009799)2.02927675
72Abnormality of the fetal cardiovascular system (HP:0010948)2.02572383
73Abnormal umbilical cord blood vessels (HP:0011403)2.02572383
74Single umbilical artery (HP:0001195)2.02572383
75Abnormality of methionine metabolism (HP:0010901)2.01743804
76Reduced antithrombin III activity (HP:0001976)2.01265474
77Partial duplication of thumb phalanx (HP:0009944)2.01262517
78Ependymoma (HP:0002888)2.00620037
79Respiratory insufficiency due to defective ciliary clearance (HP:0200073)12.4993256
80Dynein arm defect of respiratory motile cilia (HP:0012255)10.0377672
81Absent/shortened dynein arms (HP:0200106)10.0377672
82Ketosis (HP:0001946)1.97233454
83Missing ribs (HP:0000921)1.96801947
84Diaphragmatic weakness (HP:0009113)1.94824725
85Abnormality of the umbilical cord (HP:0010881)1.93915157
86Abnormality of the distal phalanges of the toes (HP:0010182)1.93504603
87J-shaped sella turcica (HP:0002680)1.91775151
88Aplasia/Hypoplasia of the tongue (HP:0010295)1.90757312
89Chromosomal breakage induced by crosslinking agents (HP:0003221)1.90711993
90Renal dysplasia (HP:0000110)1.90650326
91Lipid accumulation in hepatocytes (HP:0006561)1.85440203
92Macrocytic anemia (HP:0001972)1.85411199
93Tubulointerstitial fibrosis (HP:0005576)1.83445853
94Short phalanx of the thumb (HP:0009660)1.81147848
95Facial hemangioma (HP:0000329)1.80699299
96Microvesicular hepatic steatosis (HP:0001414)1.79268142
97Insidious onset (HP:0003587)1.79127672
98Termporal pattern (HP:0011008)1.79127672
99Abnormality of the phalanges of the hallux (HP:0010057)1.78597115
100Colon cancer (HP:0003003)1.78483108
101Abnormality of the parathyroid morphology (HP:0011766)1.78160961
102Exostoses (HP:0100777)1.78112831
103Megaloblastic anemia (HP:0001889)1.77609268
104Reticulocytopenia (HP:0001896)1.76470430
105Increased hepatocellular lipid droplets (HP:0006565)1.76259896
106Cystic liver disease (HP:0006706)1.75207153
107Hypoplasia of the capital femoral epiphysis (HP:0003090)1.74993051
108Partial duplication of the phalanx of hand (HP:0009999)1.74823170
109Enlarged penis (HP:0000040)1.74593244
110Male pseudohermaphroditism (HP:0000037)1.74270018
111Deep philtrum (HP:0002002)1.74180451
112Asymmetry of the thorax (HP:0001555)1.73716249
113Congenital hepatic fibrosis (HP:0002612)1.73411366
114Broad nasal tip (HP:0000455)1.73373863
115Short ribs (HP:0000773)1.73315049
116Acute encephalopathy (HP:0006846)1.73209514
117Hyperammonemia (HP:0001987)1.72865443
118Stage 5 chronic kidney disease (HP:0003774)1.72204122
119Abnormality of small intestinal villus morphology (HP:0011472)1.70634692
120Villous atrophy (HP:0011473)1.70634692
12111 pairs of ribs (HP:0000878)1.69977589
122Cone-rod dystrophy (HP:0000548)1.69585380
123Pancreatic cysts (HP:0001737)1.68820623
124True hermaphroditism (HP:0010459)1.68655165
125Postaxial hand polydactyly (HP:0001162)1.67847482
126Recurrent bronchitis (HP:0002837)1.67595464
127Increased neuronal autofluorescent lipopigment (HP:0002074)1.67555982
128Right ventricular cardiomyopathy (HP:0011663)1.67493826
129Neoplasm of the adrenal cortex (HP:0100641)1.67166362
130Aplasia/Hypoplasia involving the musculature (HP:0001460)1.66969594
131Ectopic kidney (HP:0000086)1.66342367
132Depressed nasal tip (HP:0000437)1.66136726
133Hypokinesia (HP:0002375)1.65530972
134Abnormality of sulfur amino acid metabolism (HP:0004339)1.64908242
135Rib fusion (HP:0000902)1.63787230
136Heterotopia (HP:0002282)1.62448906
137Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.62349645
138Degeneration of the lateral corticospinal tracts (HP:0002314)1.62349645
139Ketoacidosis (HP:0001993)1.61892877
140Renal Fanconi syndrome (HP:0001994)1.61804305
141Abnormality of the renal cortex (HP:0011035)1.61755740
142Lethargy (HP:0001254)1.61365446
143Abnormal foot bone ossification (HP:0010675)1.60489571
144Aplasia/Hypoplasia of the uvula (HP:0010293)1.60102812
145Hyperinsulinemic hypoglycemia (HP:0000825)1.58958301
146Patellar aplasia (HP:0006443)1.58849128
147Sloping forehead (HP:0000340)1.58119962
148Increased CSF lactate (HP:0002490)1.57418123
149Hyperglycinemia (HP:0002154)1.57222488
150Gonadotropin excess (HP:0000837)1.56572464
151Insulin-resistant diabetes mellitus (HP:0000831)1.55787331
152Occipital encephalocele (HP:0002085)1.53551112
153Decreased central vision (HP:0007663)1.50632054
154Shawl scrotum (HP:0000049)1.50316941
155Poor coordination (HP:0002370)1.49955439
156Abnormal biliary tract physiology (HP:0012439)1.49649228
157Bile duct proliferation (HP:0001408)1.49649228
158Congenital primary aphakia (HP:0007707)1.49514278
159Dyschromatopsia (HP:0007641)1.49236603
160Oculomotor apraxia (HP:0000657)1.48036077
161Capillary hemangiomas (HP:0005306)1.47932489
162Hypergonadotropic hypogonadism (HP:0000815)1.46411552
163Breast hypoplasia (HP:0003187)1.45639974
164Aplasia/Hypoplasia of the lens (HP:0008063)1.45619009
165Fatigable weakness (HP:0003473)1.45384378
166Abnormality of the neuromuscular junction (HP:0003398)1.45384378
167Gait imbalance (HP:0002141)1.44960810
168Nephroblastoma (Wilms tumor) (HP:0002667)1.44379913
169Facial cleft (HP:0002006)1.42767462
170Abnormality of permanent molar morphology (HP:0011071)1.42596374
171Abnormality of the dental root (HP:0006486)1.42596374
172Taurodontia (HP:0000679)1.42596374
173Abnormality of the preputium (HP:0100587)1.42449792
174Acute myeloid leukemia (HP:0004808)1.42151750
175Duodenal stenosis (HP:0100867)1.42043522
176Small intestinal stenosis (HP:0012848)1.42043522
177Abnormality of lateral ventricle (HP:0030047)1.41405114
178Meckel diverticulum (HP:0002245)1.41385410
179Polydipsia (HP:0001959)1.40526119
180Abnormal drinking behavior (HP:0030082)1.40526119
181Embryonal renal neoplasm (HP:0011794)1.40164421
182Abnormality of chromosome stability (HP:0003220)1.39531407
183Genital tract atresia (HP:0001827)1.37919454
184Short thorax (HP:0010306)1.36802584
185Pulmonary fibrosis (HP:0002206)1.35950614
186Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.35753144
187Absent epiphyses (HP:0010577)1.35753144
188Type 2 muscle fiber atrophy (HP:0003554)1.35449997
189Median cleft lip (HP:0000161)1.35411801
190Hypoplastic labia majora (HP:0000059)1.35252235
191Short femoral neck (HP:0100864)1.34598451

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK35.97798790
2PDK45.97798790
3PRKD35.23787504
4TESK14.50068887
5PDK23.71623751
6PKN23.71316008
7VRK23.39052683
8EPHA23.22058087
9STK38L2.85477786
10ICK2.82148575
11LATS12.76271460
12PBK2.73569161
13PLK42.60451323
14LATS22.39708619
15CAMK1D2.38800638
16TTK2.35517128
17MAP3K62.35099459
18STK162.30755849
19TAF12.29307621
20NEK22.28371702
21SCYL22.12802663
22SMG12.06449653
23EEF2K2.02296975
24STK382.00196491
25ERBB41.88927422
26PRKCI1.84279115
27CAMK1G1.82595393
28CDC71.80789018
29TNK21.76064411
30MUSK1.75329620
31EIF2AK11.72271612
32STK31.71511205
33STK391.70881992
34NME21.68484534
35BCKDK1.61697563
36MST41.60242658
37TAOK31.52823119
38AKT31.51228553
39FER1.50652677
40PTK2B1.49199059
41SIK11.48645640
42TSSK61.45184844
43ZAK1.42948649
44WNK41.40436501
45BRAF1.39500966
46EIF2AK31.30403815
47TLK11.30318411
48CHEK21.28647017
49KSR21.27074087
50SRPK11.25084981
51MAPK151.16439221
52LMTK21.13889906
53ILK1.06584428
54PASK1.03744274
55NEK61.03545434
56TAOK11.01028757
57TYRO31.00686991
58MOS1.00586421
59PLK11.00065615
60BUB10.96535508
61NUAK10.93156934
62GRK10.92507976
63LRRK20.92030600
64RPS6KA20.91216529
65MAPKAPK30.91061205
66DYRK20.87376275
67MAP2K20.86630093
68DYRK30.84010310
69MAP3K90.83807359
70CDK90.82391748
71MAPKAPK50.81898763
72STK100.81064506
73PTK60.81018146
74MAP3K120.76966224
75PDK10.72750695
76RAF10.70550971
77CHUK0.68702345
78CHEK10.68153535
79MAP3K130.67918296
80PIK3CA0.67420565
81RPS6KB10.65678296
82RPS6KL10.65603907
83RPS6KC10.65603907
84CDK80.63781074
85PIM20.63328198
86PNCK0.61697884
87MELK0.61694229
88PAK40.61293847
89DYRK1B0.60666184
90AURKB0.60287344
91AKT20.59878904
92RPS6KA60.59289646
93ATM0.58191073
94ERN10.57959264
95MAP3K40.57484092
96BMPR20.56001559
97ARAF0.55148170
98PAK60.54573669
99GRK60.52235817
100MATK0.50967765
101MAP3K80.50506990
102PRKAA10.49928868
103CSNK2A20.49131079
104WEE10.47536019
105MAP2K70.47243729
106PDPK10.46468554
107NEK10.43940221
108CSNK1E0.43281564
109AURKA0.41880455
110ATR0.41182357
111BRSK20.39891032
112TRIM280.39809962
113PAK10.39087271
114FGFR40.37926237
115INSRR0.37804150
116MAPK130.36222276
117RPS6KA10.36100053
118CSNK2A10.35736366
119NME10.35018470
120PRKAA20.34580950
121MARK20.32859317
122CDK30.32720074
123PLK30.31533960
124DAPK10.31368511
125YES10.31147081
126ERBB20.30002071
127ACVR1B0.28881740
128ABL20.28801222
129PRKD10.28739954
130PRKD20.27788387
131BMPR1B0.27157696
132BRSK10.27082176
133CSNK1A10.27063978
134KSR10.26556513
135PINK10.26016809
136AKT10.24673805
137MAP3K50.24511630
138TESK20.23668941
139FRK0.22516052
140MAP2K60.21825397
141CDK120.20855777
142CDK40.19963912
143TRIB30.19918624
144CDK70.19364573
145CDK20.19011125
146CDK10.18948512
147RIPK10.15831892
148MTOR0.14719177
149RPS6KA40.14489417
150TRPM70.13976141
151IRAK10.12903586
152CCNB10.11747847
153RPS6KB20.11666508
154WNK10.09871652
155NTRK20.08454862
156MAP3K10.08420903
157VRK10.08401317
158HIPK20.07996079
159CAMK2A0.07169080

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007504.10352828
2Basal transcription factors_Homo sapiens_hsa030224.09779573
3alpha-Linolenic acid metabolism_Homo sapiens_hsa005923.62729424
4Linoleic acid metabolism_Homo sapiens_hsa005913.50975637
5Cell cycle_Homo sapiens_hsa041103.07603361
6Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.87166794
7Ribosome_Homo sapiens_hsa030102.85634020
8Fanconi anemia pathway_Homo sapiens_hsa034602.84689651
9Fatty acid biosynthesis_Homo sapiens_hsa000612.78652808
10RNA degradation_Homo sapiens_hsa030182.59075316
11Oocyte meiosis_Homo sapiens_hsa041142.46124237
12Pyruvate metabolism_Homo sapiens_hsa006202.27991488
13Cyanoamino acid metabolism_Homo sapiens_hsa004602.18525987
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.08994327
15Ether lipid metabolism_Homo sapiens_hsa005652.07700486
16RNA transport_Homo sapiens_hsa030132.03040799
17Proteasome_Homo sapiens_hsa030501.98842676
18Sulfur relay system_Homo sapiens_hsa041221.92347521
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.91441787
20Dorso-ventral axis formation_Homo sapiens_hsa043201.82884606
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.82807354
22Pentose phosphate pathway_Homo sapiens_hsa000301.81826861
23Homologous recombination_Homo sapiens_hsa034401.81154841
24One carbon pool by folate_Homo sapiens_hsa006701.78991086
25Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.68864907
26mRNA surveillance pathway_Homo sapiens_hsa030151.65697860
27Vitamin digestion and absorption_Homo sapiens_hsa049771.65476513
28Propanoate metabolism_Homo sapiens_hsa006401.62686927
29Ovarian steroidogenesis_Homo sapiens_hsa049131.59383863
30Fatty acid elongation_Homo sapiens_hsa000621.57189707
31Glycerophospholipid metabolism_Homo sapiens_hsa005641.55473458
32Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.49681830
33Phenylalanine metabolism_Homo sapiens_hsa003601.49651386
34Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.47188876
35Spliceosome_Homo sapiens_hsa030401.43816382
36DNA replication_Homo sapiens_hsa030301.43273805
37Peroxisome_Homo sapiens_hsa041461.43018360
38Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42327352
39Oxidative phosphorylation_Homo sapiens_hsa001901.41592094
40Cysteine and methionine metabolism_Homo sapiens_hsa002701.39047122
41Base excision repair_Homo sapiens_hsa034101.38575350
42Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.38243730
43Steroid biosynthesis_Homo sapiens_hsa001001.35096872
44Selenocompound metabolism_Homo sapiens_hsa004501.33712991
45Mineral absorption_Homo sapiens_hsa049781.30942326
462-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.29138811
47Purine metabolism_Homo sapiens_hsa002301.27278822
48Glycerolipid metabolism_Homo sapiens_hsa005611.26617486
49beta-Alanine metabolism_Homo sapiens_hsa004101.26439876
50Arachidonic acid metabolism_Homo sapiens_hsa005901.23793061
51Glutathione metabolism_Homo sapiens_hsa004801.23313867
52Circadian rhythm_Homo sapiens_hsa047101.22604964
53Glycosaminoglycan degradation_Homo sapiens_hsa005311.17471442
54N-Glycan biosynthesis_Homo sapiens_hsa005101.16128323
55Lysine degradation_Homo sapiens_hsa003101.15013594
56* Glucagon signaling pathway_Homo sapiens_hsa049221.14956997
57TGF-beta signaling pathway_Homo sapiens_hsa043501.14762944
58Tyrosine metabolism_Homo sapiens_hsa003501.13351332
59p53 signaling pathway_Homo sapiens_hsa041151.12484619
60Carbohydrate digestion and absorption_Homo sapiens_hsa049731.12129185
61Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11767600
62Mismatch repair_Homo sapiens_hsa034301.10904299
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.07843811
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.07499616
65Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.04644759
66Non-homologous end-joining_Homo sapiens_hsa034501.02604484
67Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.01920451
68Histidine metabolism_Homo sapiens_hsa003401.00276867
69Hedgehog signaling pathway_Homo sapiens_hsa043400.99542430
70Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.98718782
71Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98643945
72Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97326213
73Thyroid cancer_Homo sapiens_hsa052160.97066531
74Protein export_Homo sapiens_hsa030600.96950544
75Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.96796425
76Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.96667312
77Arginine and proline metabolism_Homo sapiens_hsa003300.96202017
78Nucleotide excision repair_Homo sapiens_hsa034200.96011258
79Parkinsons disease_Homo sapiens_hsa050120.93550484
80Caffeine metabolism_Homo sapiens_hsa002320.93507228
81Pyrimidine metabolism_Homo sapiens_hsa002400.93064387
82Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90454765
83Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.89211781
84PPAR signaling pathway_Homo sapiens_hsa033200.86902936
85Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.86697295
86Fat digestion and absorption_Homo sapiens_hsa049750.78140627
87Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76492846
88Pancreatic cancer_Homo sapiens_hsa052120.74483284
89Biosynthesis of amino acids_Homo sapiens_hsa012300.73174013
90Butanoate metabolism_Homo sapiens_hsa006500.72599156
91Adherens junction_Homo sapiens_hsa045200.72196474
92Chemical carcinogenesis_Homo sapiens_hsa052040.71827418
93Folate biosynthesis_Homo sapiens_hsa007900.71647734
94VEGF signaling pathway_Homo sapiens_hsa043700.70682964
95Endometrial cancer_Homo sapiens_hsa052130.67005228
96Hippo signaling pathway_Homo sapiens_hsa043900.63533293
97* AMPK signaling pathway_Homo sapiens_hsa041520.62917005
98RNA polymerase_Homo sapiens_hsa030200.62552024
99* Prostate cancer_Homo sapiens_hsa052150.61411287
100Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61062921
101Fructose and mannose metabolism_Homo sapiens_hsa000510.57669594
102* Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57191650
103Thyroid hormone signaling pathway_Homo sapiens_hsa049190.54930148
104Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.52984109
105Sulfur metabolism_Homo sapiens_hsa009200.49864892
106Fatty acid degradation_Homo sapiens_hsa000710.48935868
107Steroid hormone biosynthesis_Homo sapiens_hsa001400.48685851
108Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.48083863
109Carbon metabolism_Homo sapiens_hsa012000.47753982
110mTOR signaling pathway_Homo sapiens_hsa041500.47747997
111Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.47366591
112Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47333333
113ABC transporters_Homo sapiens_hsa020100.47316695
114Tryptophan metabolism_Homo sapiens_hsa003800.46121675
115Alzheimers disease_Homo sapiens_hsa050100.45938415
116Inositol phosphate metabolism_Homo sapiens_hsa005620.45421166
117Primary bile acid biosynthesis_Homo sapiens_hsa001200.45232515
118Notch signaling pathway_Homo sapiens_hsa043300.44821662
119Drug metabolism - other enzymes_Homo sapiens_hsa009830.44343185
120Choline metabolism in cancer_Homo sapiens_hsa052310.44176615
121Prolactin signaling pathway_Homo sapiens_hsa049170.42907318
122Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42896391
123Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.42591069
124Basal cell carcinoma_Homo sapiens_hsa052170.42573370
125Tight junction_Homo sapiens_hsa045300.42135267
126Herpes simplex infection_Homo sapiens_hsa051680.41429066
127Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.40809145
128MicroRNAs in cancer_Homo sapiens_hsa052060.40647499
129Wnt signaling pathway_Homo sapiens_hsa043100.39469603
130Sphingolipid metabolism_Homo sapiens_hsa006000.34937521
131HTLV-I infection_Homo sapiens_hsa051660.34570667
132Huntingtons disease_Homo sapiens_hsa050160.32229425
133Retinol metabolism_Homo sapiens_hsa008300.32146341
134Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.31538970
135Pentose and glucuronate interconversions_Homo sapiens_hsa000400.31418885
136Small cell lung cancer_Homo sapiens_hsa052220.31231878
137Colorectal cancer_Homo sapiens_hsa052100.31108473
138Influenza A_Homo sapiens_hsa051640.30932240
139Fatty acid metabolism_Homo sapiens_hsa012120.30772247
140Other glycan degradation_Homo sapiens_hsa005110.29872959
141Epstein-Barr virus infection_Homo sapiens_hsa051690.29162002
142Renin-angiotensin system_Homo sapiens_hsa046140.26689854
143Central carbon metabolism in cancer_Homo sapiens_hsa052300.26490411
144Systemic lupus erythematosus_Homo sapiens_hsa053220.21984052
145Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21761391
146Protein digestion and absorption_Homo sapiens_hsa049740.21565019
147GnRH signaling pathway_Homo sapiens_hsa049120.21518044
148Metabolic pathways_Homo sapiens_hsa011000.21242210
149Shigellosis_Homo sapiens_hsa051310.20456795
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.19908158
151Adipocytokine signaling pathway_Homo sapiens_hsa049200.19223046
152Vascular smooth muscle contraction_Homo sapiens_hsa042700.18758181
153* Estrogen signaling pathway_Homo sapiens_hsa049150.18271407
154Ras signaling pathway_Homo sapiens_hsa040140.16627724

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