CREB5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The product of this gene belongs to the CRE (cAMP response element)-binding protein family. Members of this family contain zinc-finger and bZIP DNA-binding domains. The encoded protein specifically binds to CRE as a homodimer or a heterodimer with c-Jun or CRE-BP1, and functions as a CRE-dependent trans-activator. Alternatively spliced transcript variants encoding different isoforms have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.34017153
2positive regulation by organism of defense response of other organism involved in symbiotic interact6.34017153
3modulation by symbiont of host immune response (GO:0052553)6.34017153
4positive regulation by symbiont of host defense response (GO:0052509)6.34017153
5modulation by symbiont of host defense response (GO:0052031)6.34017153
6modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.34017153
7detection of molecule of bacterial origin (GO:0032490)6.08041861
8positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)5.66701235
9microglial cell activation (GO:0001774)5.27408597
10macrophage activation involved in immune response (GO:0002281)5.02163656
11negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.72953118
12negative regulation of cell killing (GO:0031342)4.72953118
13leukocyte migration involved in inflammatory response (GO:0002523)4.60822917
14detection of external biotic stimulus (GO:0098581)4.46507935
15regulation of B cell receptor signaling pathway (GO:0050855)4.44648904
16antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G4.42850019
17positive regulation of gamma-delta T cell activation (GO:0046645)4.32356392
18response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.32301139
19response to host immune response (GO:0052572)4.32301139
20neutrophil mediated immunity (GO:0002446)4.30123445
21regulation of interferon-beta biosynthetic process (GO:0045357)4.29366061
22detection of other organism (GO:0098543)4.21182423
23cellular extravasation (GO:0045123)4.19201171
24macrophage activation (GO:0042116)4.18295518
25regulation of nitric-oxide synthase biosynthetic process (GO:0051769)3.98528817
26neutrophil activation involved in immune response (GO:0002283)3.98454862
27response to peptidoglycan (GO:0032494)3.92819119
28response to host (GO:0075136)3.91031870
29response to host defenses (GO:0052200)3.91031870
30response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.91031870
31detection of biotic stimulus (GO:0009595)3.85023778
32positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)3.78366252
33negative regulation of lymphocyte mediated immunity (GO:0002707)3.78204775
34neutrophil activation (GO:0042119)3.74917024
35myeloid leukocyte mediated immunity (GO:0002444)3.56968295
36negative regulation of interleukin-12 production (GO:0032695)3.51231539
37detection of bacterium (GO:0016045)3.48936510
38negative regulation of B cell mediated immunity (GO:0002713)3.44972039
39negative regulation of immunoglobulin mediated immune response (GO:0002890)3.44972039
40negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.42475407
41positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.40776804
42cellular response to interleukin-15 (GO:0071350)3.37267777
43response to interleukin-15 (GO:0070672)3.33282745
44regulation of ER to Golgi vesicle-mediated transport (GO:0060628)3.31220788
45negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.22782984
46leukocyte aggregation (GO:0070486)3.21586346
47activated T cell proliferation (GO:0050798)3.20587846
48cerebral cortex radially oriented cell migration (GO:0021799)3.18955978
49production of molecular mediator involved in inflammatory response (GO:0002532)3.15514584
50granulocyte activation (GO:0036230)3.12844946
51respiratory burst (GO:0045730)3.07290879
52negative regulation of adaptive immune response based on somatic recombination of immune receptors b3.06218166
53negative regulation of alpha-beta T cell differentiation (GO:0046639)3.04311379
54negative regulation of neurotransmitter transport (GO:0051589)3.04311176
55negative regulation of T cell mediated immunity (GO:0002710)3.03038392
56positive regulation of mast cell activation (GO:0033005)2.98989127
57regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.97893109
58negative regulation of cAMP-mediated signaling (GO:0043951)2.96457109
59dendritic cell migration (GO:0036336)2.96345677
60myeloid cell activation involved in immune response (GO:0002275)2.95446042
61negative regulation of leukocyte mediated immunity (GO:0002704)2.94920842
62negative regulation of adaptive immune response (GO:0002820)2.94759056
63neural tube formation (GO:0001841)2.94198816
64negative regulation of alpha-beta T cell activation (GO:0046636)2.93455346
65positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.92567792
66positive regulation of cellular amide metabolic process (GO:0034250)2.91277190
67regulation of gamma-delta T cell activation (GO:0046643)2.90463206
68olfactory bulb development (GO:0021772)2.87403988
69regulation of interleukin-6 biosynthetic process (GO:0045408)2.85627981
70positive regulation of toll-like receptor signaling pathway (GO:0034123)2.84805220
71negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.82695855
72negative regulation of T-helper cell differentiation (GO:0045623)2.82695855
73T-helper 1 type immune response (GO:0042088)2.82466911
74regulation of mast cell activation (GO:0033003)2.81012264
75radial glial cell differentiation (GO:0060019)2.80961081
76antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.79063230
77negative thymic T cell selection (GO:0045060)2.77116351
78antigen processing and presentation of endogenous antigen (GO:0019883)2.72174171
79negative regulation of B cell proliferation (GO:0030889)2.65672001
80regulation of macrophage cytokine production (GO:0010935)2.64400117
81B cell receptor signaling pathway (GO:0050853)2.64116100
82negative T cell selection (GO:0043383)2.62526021
83regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.59966683
84presynaptic membrane assembly (GO:0097105)2.59461757
85tongue development (GO:0043586)2.57026835
86regulation of mast cell activation involved in immune response (GO:0033006)2.56617477
87regulation of interleukin-8 biosynthetic process (GO:0045414)2.56438265
88negative regulation of neurotransmitter secretion (GO:0046929)2.55844417
89neutrophil chemotaxis (GO:0030593)2.54841526
90regulation of mast cell degranulation (GO:0043304)2.53977520
91I-kappaB phosphorylation (GO:0007252)2.50724859
92germinal center formation (GO:0002467)2.49794569
93positive regulation of macrophage cytokine production (GO:0060907)2.48247736
94neutrophil migration (GO:1990266)2.48181391
95cytokine secretion (GO:0050663)2.46664738
96positive regulation of interleukin-1 beta secretion (GO:0050718)2.44498011
97negative regulation of interleukin-1 production (GO:0032692)2.40690169
98defense response to protozoan (GO:0042832)2.40496620
99positive regulation of mast cell degranulation (GO:0043306)2.39935154
100positive regulation of mast cell activation involved in immune response (GO:0033008)2.39935154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.02498839
2SMAD_19615063_ChIP-ChIP_OVARY_Human2.84256719
3FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.83168469
4GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.78568065
5CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.73985149
6IRF8_21731497_ChIP-ChIP_J774_Mouse2.72995950
7STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.64408013
8GBX2_23144817_ChIP-Seq_PC3_Human2.57440248
9BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.44299094
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.33237872
11SALL1_21062744_ChIP-ChIP_HESCs_Human2.09689550
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06293921
13* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.94904104
14* IRF8_27001747_Chip-Seq_BMDM_Mouse1.93781983
15PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.92326446
16ZFP57_27257070_Chip-Seq_ESCs_Mouse1.86972534
17BP1_19119308_ChIP-ChIP_Hs578T_Human1.82396491
18VDR_24787735_ChIP-Seq_THP-1_Human1.81999323
19STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.81187518
20CDX2_19796622_ChIP-Seq_MESCs_Mouse1.80546153
21TAF15_26573619_Chip-Seq_HEK293_Human1.79424147
22AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.73651463
23SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.73148147
24RUNX_20019798_ChIP-Seq_JUKART_Human1.72432642
25SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.67830357
26MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.65850731
27TP53_16413492_ChIP-PET_HCT116_Human1.65597950
28* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59892862
29* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.55511977
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.53592702
31P300_19829295_ChIP-Seq_ESCs_Human1.53050105
32* SMAD4_21799915_ChIP-Seq_A2780_Human1.47948419
33IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.46398755
34ER_23166858_ChIP-Seq_MCF-7_Human1.45960912
35PIAS1_25552417_ChIP-Seq_VCAP_Human1.45338282
36IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.44568083
37MYB_21317192_ChIP-Seq_ERMYB_Mouse1.44051264
38* TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.41158924
39* POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.41158924
40PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39542451
41CTBP2_25329375_ChIP-Seq_LNCAP_Human1.38966347
42BCAT_22108803_ChIP-Seq_LS180_Human1.37620301
43AR_21572438_ChIP-Seq_LNCaP_Human1.37540599
44VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.37079597
45MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.36494767
46UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.36267921
47IGF1R_20145208_ChIP-Seq_DFB_Human1.35009967
48ZNF274_21170338_ChIP-Seq_K562_Hela1.34366269
49CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.28157498
50* STAT3_23295773_ChIP-Seq_U87_Human1.28016713
51SPI1_23127762_ChIP-Seq_K562_Human1.24455363
52FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.22698691
53* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.21800347
54RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.17122189
55CTBP1_25329375_ChIP-Seq_LNCAP_Human1.17049168
56FLI1_21867929_ChIP-Seq_TH2_Mouse1.16726247
57NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16620432
58NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14905403
59EZH2_27294783_Chip-Seq_NPCs_Mouse1.14525553
60TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12764429
61P53_22127205_ChIP-Seq_FIBROBLAST_Human1.12698169
62CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.11257167
63NOTCH1_21737748_ChIP-Seq_TLL_Human1.11236798
64AR_25329375_ChIP-Seq_VCAP_Human1.11056824
65SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11020001
66NANOG_18555785_Chip-Seq_ESCs_Mouse1.10719122
67* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.10242276
68* TCF4_23295773_ChIP-Seq_U87_Human1.08572857
69PRDM14_20953172_ChIP-Seq_ESCs_Human1.08366422
70* KDM2B_26808549_Chip-Seq_REH_Human1.08149830
71SCL_19346495_ChIP-Seq_HPC-7_Human1.07250140
72FLI1_27457419_Chip-Seq_LIVER_Mouse1.07192388
73SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.06797925
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.05886748
75IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05778826
76CBP_20019798_ChIP-Seq_JUKART_Human1.05778826
77TOP2B_26459242_ChIP-Seq_MCF-7_Human1.05669161
78MYB_26560356_Chip-Seq_TH2_Human1.04998050
79* RUNX2_22187159_ChIP-Seq_PCA_Human1.03354504
80EWS_26573619_Chip-Seq_HEK293_Human1.03293932
81GATA3_27048872_Chip-Seq_THYMUS_Human1.03155169
82CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.02909734
83NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.02552052
84NRF2_20460467_ChIP-Seq_MEFs_Mouse1.02552052
85ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.02505925
86RXR_22108803_ChIP-Seq_LS180_Human1.01372828
87KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.00765469
88SMRT_27268052_Chip-Seq_Bcells_Human1.00026871
89SPI1_23547873_ChIP-Seq_NB4_Human0.99353028
90ARNT_22903824_ChIP-Seq_MCF-7_Human0.99283880
91* CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.98661480
92NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.98276074
93TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.98200677
94* SOX2_21211035_ChIP-Seq_LN229_Gbm0.97594982
95TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.97020296
96CBX2_27304074_Chip-Seq_ESCs_Mouse0.97010298
97TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96300766
98LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95959847
99GATA3_26560356_Chip-Seq_TH2_Human0.95783407
100STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.95597553

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003724_increased_susceptibility_to5.97588918
2MP0000569_abnormal_digit_pigmentation4.03122209
3MP0003303_peritoneal_inflammation3.04257921
4MP0005248_abnormal_Harderian_gland2.92569718
5MP0003436_decreased_susceptibility_to2.64504085
6MP0002419_abnormal_innate_immunity2.49130439
7MP0001835_abnormal_antigen_presentation2.33529526
8MP0002277_abnormal_respiratory_mucosa2.19297866
9MP0002928_abnormal_bile_duct2.15881889
10MP0003828_pulmonary_edema2.11229315
11MP0001800_abnormal_humoral_immune2.07069258
12MP0006082_CNS_inflammation2.06874432
13MP0006292_abnormal_olfactory_placode2.05987178
14MP0004883_abnormal_blood_vessel2.04010633
15MP0008260_abnormal_autophagy2.02145551
16MP0003690_abnormal_glial_cell1.90231568
17MP0009785_altered_susceptibility_to1.87136432
18MP0002723_abnormal_immune_serum1.75274524
19MP0008789_abnormal_olfactory_epithelium1.73075852
20MP0005025_abnormal_response_to1.73015707
21MP0000685_abnormal_immune_system1.71891914
22MP0003183_abnormal_peptide_metabolism1.69224379
23MP0002420_abnormal_adaptive_immunity1.68274167
24MP0009764_decreased_sensitivity_to1.67175625
25MP0002452_abnormal_antigen_presenting1.63684344
26MP0001819_abnormal_immune_cell1.62921957
27MP0005000_abnormal_immune_tolerance1.62258523
28MP0003880_abnormal_central_pattern1.62049537
29MP0005671_abnormal_response_to1.61173866
30MP0002653_abnormal_ependyma_morphology1.60541413
31MP0001486_abnormal_startle_reflex1.55711333
32MP0000778_abnormal_nervous_system1.51693621
33MP0005387_immune_system_phenotype1.45966635
34MP0001790_abnormal_immune_system1.45966635
35MP0003191_abnormal_cellular_cholesterol1.44753923
36MP0002405_respiratory_system_inflammati1.41533403
37MP0003300_gastrointestinal_ulcer1.38523024
38MP0006054_spinal_hemorrhage1.38457172
39MP0005084_abnormal_gallbladder_morpholo1.36752082
40MP0004381_abnormal_hair_follicle1.35276412
41MP0005164_abnormal_response_to1.34148039
42MP0003045_fibrosis1.32259946
43MP0004484_altered_response_of1.31832483
44MP0001533_abnormal_skeleton_physiology1.31328568
45MP0005394_taste/olfaction_phenotype1.27709639
46MP0005499_abnormal_olfactory_system1.27709639
47MP0005310_abnormal_salivary_gland1.27475520
48MP0002132_abnormal_respiratory_system1.26704697
49MP0005174_abnormal_tail_pigmentation1.24481205
50MP0005388_respiratory_system_phenotype1.18489504
51MP0002133_abnormal_respiratory_system1.18489504
52MP0000465_gastrointestinal_hemorrhage1.18034880
53MP0000427_abnormal_hair_cycle1.16371215
54MP0003011_delayed_dark_adaptation1.16317747
55MP0000716_abnormal_immune_system1.13006165
56MP0003787_abnormal_imprinting1.12546775
57MP0002168_other_aberrant_phenotype1.09536490
58MP0009053_abnormal_anal_canal1.07647906
59MP0001958_emphysema1.05864897
60MP0000516_abnormal_urinary_system1.05650037
61MP0005367_renal/urinary_system_phenotyp1.05650037
62MP0004885_abnormal_endolymph1.04788071
63MP0009278_abnormal_bone_marrow1.04163036
64MP0003195_calcinosis1.03416374
65MP0002398_abnormal_bone_marrow1.00286409
66MP0000015_abnormal_ear_pigmentation0.99513079
67MP0000920_abnormal_myelination0.99007615
68MP0002148_abnormal_hypersensitivity_rea0.98667328
69MP0003252_abnormal_bile_duct0.97438120
70MP0003656_abnormal_erythrocyte_physiolo0.94840784
71MP0003938_abnormal_ear_development0.93548498
72MP0001845_abnormal_inflammatory_respons0.93434216
73MP0001851_eye_inflammation0.91454725
74MP0001545_abnormal_hematopoietic_system0.91346227
75MP0005397_hematopoietic_system_phenotyp0.91346227
76MP0003075_altered_response_to0.86047051
77MP0003633_abnormal_nervous_system0.85682735
78MP0003172_abnormal_lysosome_physiology0.84721373
79MP0002332_abnormal_exercise_endurance0.81215829
80MP0000613_abnormal_salivary_gland0.81166387
81MP0003943_abnormal_hepatobiliary_system0.79833868
82MP0003221_abnormal_cardiomyocyte_apopto0.79362611
83MP0001177_atelectasis0.77604657
84MP0000631_abnormal_neuroendocrine_gland0.75105905
85MP0000689_abnormal_spleen_morphology0.75085498
86MP0002722_abnormal_immune_system0.74790561
87MP0005451_abnormal_body_composition0.73051747
88MP0000703_abnormal_thymus_morphology0.72772875
89MP0001986_abnormal_taste_sensitivity0.72332671
90MP0000566_synostosis0.69511580
91MP0003866_abnormal_defecation0.69382338
92MP0005167_abnormal_blood-brain_barrier0.69014959
93MP0005253_abnormal_eye_physiology0.68810617
94MP0003121_genomic_imprinting0.67825316
95MP0004142_abnormal_muscle_tone0.66856170
96MP0004130_abnormal_muscle_cell0.66388866
97MP0002396_abnormal_hematopoietic_system0.65792528
98MP0002429_abnormal_blood_cell0.65476975
99MP0001324_abnormal_eye_pigmentation0.65376709
100MP0005075_abnormal_melanosome_morpholog0.65284417

Predicted human phenotypes

RankGene SetZ-score
1Orchitis (HP:0100796)4.88613193
2Retrobulbar optic neuritis (HP:0100654)4.88227242
3Optic neuritis (HP:0100653)4.88227242
4Myositis (HP:0100614)4.60714705
5Recurrent bacterial skin infections (HP:0005406)4.53289659
6Recurrent abscess formation (HP:0002722)4.37393413
7Eczematoid dermatitis (HP:0000976)4.31476039
8Hypochromic microcytic anemia (HP:0004840)4.12249303
9Stomatitis (HP:0010280)4.01554510
10Recurrent gram-negative bacterial infections (HP:0005420)3.68266265
11Keratoconjunctivitis sicca (HP:0001097)3.63781812
12Keratoconjunctivitis (HP:0001096)3.48811681
13Gastrointestinal infarctions (HP:0005244)3.35164622
14Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.34803466
15Short 4th metacarpal (HP:0010044)3.34803466
16Recurrent fungal infections (HP:0002841)3.10614819
17Peritonitis (HP:0002586)3.06868687
18Amyotrophic lateral sclerosis (HP:0007354)3.06151992
19Abnormality of macrophages (HP:0004311)3.03269675
20Abnormal delayed hypersensitivity skin test (HP:0002963)2.98911151
21True hermaphroditism (HP:0010459)2.97651341
22Hemiplegia (HP:0002301)2.94495513
23Chronic mucocutaneous candidiasis (HP:0002728)2.93549168
24Recurrent cutaneous fungal infections (HP:0011370)2.93549168
25Recurrent skin infections (HP:0001581)2.91405155
26Elevated erythrocyte sedimentation rate (HP:0003565)2.87107385
27Encephalitis (HP:0002383)2.84467037
28Episodic fever (HP:0001954)2.80924284
29Mediastinal lymphadenopathy (HP:0100721)2.79981934
30Papillary thyroid carcinoma (HP:0002895)2.73948050
31Spontaneous hematomas (HP:0007420)2.70929907
32Chest pain (HP:0100749)2.69500778
33Difficulty running (HP:0009046)2.67688222
34Hypochromic anemia (HP:0001931)2.50691636
35Stomach cancer (HP:0012126)2.50127895
36Abnormality of the 4th metacarpal (HP:0010012)2.49555407
37Meningitis (HP:0001287)2.46449257
38Hemoptysis (HP:0002105)2.38650184
39Pancreatic fibrosis (HP:0100732)2.37572038
40Subacute progressive viral hepatitis (HP:0006572)2.34460110
41Pancreatic cysts (HP:0001737)2.27906784
42Urticaria (HP:0001025)2.25315281
43Vasculitis (HP:0002633)2.24745675
44Gingivitis (HP:0000230)2.24732845
45Leukocytosis (HP:0001974)2.24335405
46Aqueductal stenosis (HP:0002410)2.23074298
47Toxemia of pregnancy (HP:0100603)2.22491246
48Arterial thrombosis (HP:0004420)2.18805517
49Abnormality of T cell number (HP:0011839)2.18312111
50Abnormality of the pleura (HP:0002103)2.17866028
51T lymphocytopenia (HP:0005403)2.15733163
52Widely spaced teeth (HP:0000687)2.15492426
53Hyperventilation (HP:0002883)2.10547140
54Obstructive lung disease (HP:0006536)2.08931915
55Chronic obstructive pulmonary disease (HP:0006510)2.08931915
56Abnormality of incisor morphology (HP:0011063)2.06105256
57Abnormality of the peritoneum (HP:0002585)2.04847129
58Keratitis (HP:0000491)2.04500996
59Aplasia/Hypoplasia of the tongue (HP:0010295)2.04160818
60Gingival bleeding (HP:0000225)2.03414278
61Excessive salivation (HP:0003781)2.03186130
62Papilledema (HP:0001085)2.00274354
63Pulmonary infiltrates (HP:0002113)1.98402455
64Progressive cerebellar ataxia (HP:0002073)1.98106688
65Vitreoretinal degeneration (HP:0000655)1.96137415
66Oligodactyly (HP:0012165)1.92998259
67Pulmonary embolism (HP:0002204)1.91520519
68Genetic anticipation (HP:0003743)1.90447810
69Facial hemangioma (HP:0000329)1.88619924
70Microcytic anemia (HP:0001935)1.86547672
71Abnormality of the endocardium (HP:0004306)1.85604284
72Palpebral edema (HP:0100540)1.84647862
73Tented upper lip vermilion (HP:0010804)1.83364150
74Abnormality of the aortic arch (HP:0012303)1.79784945
75Drooling (HP:0002307)1.77591136
76Gangrene (HP:0100758)1.77041516
77Increased IgE level (HP:0003212)1.76628927
78Viral hepatitis (HP:0006562)1.75529097
79Absent rod-and cone-mediated responses on ERG (HP:0007688)1.74951761
80Postural instability (HP:0002172)1.73958784
81Megalencephaly (HP:0001355)1.73852698
82Eosinophilia (HP:0001880)1.73092527
83Panhypogammaglobulinemia (HP:0003139)1.71548503
84Febrile seizures (HP:0002373)1.70855488
85Neoplasm of the tracheobronchial system (HP:0100552)1.70004563
86Postaxial foot polydactyly (HP:0001830)1.67245781
87Choroideremia (HP:0001139)1.65249873
88Long clavicles (HP:0000890)1.63948172
89Abnormality of the lower motor neuron (HP:0002366)1.63423196
90Abnormality of salivation (HP:0100755)1.63279232
91Hemiparesis (HP:0001269)1.63012970
92Sepsis (HP:0100806)1.62671821
93Abnormality of the metopic suture (HP:0005556)1.62011474
94Vertigo (HP:0002321)1.60395078
95Chronic hepatic failure (HP:0100626)1.60065551
96Split foot (HP:0001839)1.59812968
97Vertebral arch anomaly (HP:0008438)1.59428959
98Anorexia (HP:0002039)1.59084363
99Keratoconus (HP:0000563)1.57381768
100Increased corneal curvature (HP:0100692)1.57381768

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK43.39917164
2BLK2.99064431
3IRAK42.90013593
4FRK2.48677337
5CSK2.23652860
6EPHA32.19384684
7EPHB12.16899070
8YES12.12317868
9IRAK12.07478391
10MAP2K31.91423537
11SGK21.82064074
12TYK21.80706691
13FES1.68775832
14TNK21.64526883
15NTRK31.52002069
16TNIK1.50799453
17MAPK131.44810227
18MAP4K21.42377171
19KSR11.37329391
20HCK1.37255495
21TAOK31.36843260
22PTK2B1.36628487
23IRAK21.36023961
24SGK31.32004469
25MAP3K21.31002645
26JAK21.29702387
27CASK1.26998219
28FGR1.26397128
29KSR21.23144384
30TAOK11.21349529
31MAP4K11.21339179
32DYRK31.19173568
33SGK2231.18155327
34SGK4941.18155327
35BMPR21.17994197
36EPHB21.13905669
37PINK11.13124677
38GRK61.12634730
39WNK11.09785326
40SIK31.06536878
41MAP3K61.06509260
42LYN1.06333273
43MAP2K41.05985312
44WNK31.02674900
45JAK11.02350200
46SYK1.02287194
47BCR1.00783640
48BRSK21.00563382
49ZAP700.98541038
50FGFR20.96837653
51NTRK20.96169510
52BTK0.93922449
53STK110.91596539
54RAF10.91558814
55TXK0.91495295
56CDK190.91357589
57IKBKE0.89327009
58PAK30.89058057
59PRKD20.87405056
60EPHA40.87169039
61MARK10.85946823
62MARK30.83835131
63OXSR10.83646450
64JAK30.83342048
65BMPR1B0.79594109
66NLK0.79038941
67MAP3K30.77733586
68PIK3CG0.76914487
69MAP3K70.74367223
70CAMKK20.74144977
71TEC0.72415244
72FGFR30.72173821
73MAP3K50.69207611
74NEK90.67755274
75PNCK0.67431456
76PAK60.65586371
77BRD40.63537159
78ERBB20.62759036
79ERBB30.62728252
80SIK20.60538331
81MARK20.60492750
82PRKD30.59357736
83PLK20.57209414
84PKN10.56806769
85LCK0.56791030
86PRKCZ0.55689369
87STK100.55400569
88NUAK10.55056959
89CAMK40.54615933
90MAP3K130.53434801
91MAPK70.53059805
92FYN0.52510220
93ROCK20.51416876
94GRK50.50608976
95DYRK1A0.48650600
96DAPK20.48634373
97SGK10.48478550
98DYRK1B0.47424607
99MAP3K140.46036402
100ACVR1B0.44270947

Predicted pathways (KEGG)

RankGene SetZ-score
1Osteoclast differentiation_Homo sapiens_hsa043802.53930319
2Leishmaniasis_Homo sapiens_hsa051402.46121973
3Staphylococcus aureus infection_Homo sapiens_hsa051502.08438703
4Tuberculosis_Homo sapiens_hsa051522.02626142
5Malaria_Homo sapiens_hsa051441.99517714
6Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.91214479
7NOD-like receptor signaling pathway_Homo sapiens_hsa046211.86482263
8Dorso-ventral axis formation_Homo sapiens_hsa043201.75243970
9Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.73099344
10Legionellosis_Homo sapiens_hsa051341.66581256
11Chemokine signaling pathway_Homo sapiens_hsa040621.63840868
12Toll-like receptor signaling pathway_Homo sapiens_hsa046201.62724223
13B cell receptor signaling pathway_Homo sapiens_hsa046621.54620915
14Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52329145
15Measles_Homo sapiens_hsa051621.49083150
16African trypanosomiasis_Homo sapiens_hsa051431.48614783
17Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38217615
18Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.36070610
19Jak-STAT signaling pathway_Homo sapiens_hsa046301.30200629
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.23581637
21FoxO signaling pathway_Homo sapiens_hsa040681.20567410
22Renal cell carcinoma_Homo sapiens_hsa052111.18185593
23Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.17335180
24Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.16803003
25Toxoplasmosis_Homo sapiens_hsa051451.14639277
26Influenza A_Homo sapiens_hsa051641.12700699
27Phagosome_Homo sapiens_hsa041451.12309316
28Notch signaling pathway_Homo sapiens_hsa043301.10075237
29Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.09680565
30T cell receptor signaling pathway_Homo sapiens_hsa046601.08776339
31Neurotrophin signaling pathway_Homo sapiens_hsa047221.07180267
32Graft-versus-host disease_Homo sapiens_hsa053321.03071115
33Non-small cell lung cancer_Homo sapiens_hsa052231.02787598
34Regulation of autophagy_Homo sapiens_hsa041401.01483265
35* TNF signaling pathway_Homo sapiens_hsa046681.00078183
36Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.99564047
37Leukocyte transendothelial migration_Homo sapiens_hsa046700.99105443
38Phospholipase D signaling pathway_Homo sapiens_hsa040720.97941100
39Platelet activation_Homo sapiens_hsa046110.95491462
40* Hepatitis B_Homo sapiens_hsa051610.95299779
41Choline metabolism in cancer_Homo sapiens_hsa052310.94378099
42Pancreatic cancer_Homo sapiens_hsa052120.92857724
43Morphine addiction_Homo sapiens_hsa050320.90875776
44Rap1 signaling pathway_Homo sapiens_hsa040150.90790292
45Primary immunodeficiency_Homo sapiens_hsa053400.90240106
46Colorectal cancer_Homo sapiens_hsa052100.90238933
47AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89697216
48Allograft rejection_Homo sapiens_hsa053300.89506740
49Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.89123813
50Prolactin signaling pathway_Homo sapiens_hsa049170.88164310
51NF-kappa B signaling pathway_Homo sapiens_hsa040640.85336890
52Axon guidance_Homo sapiens_hsa043600.85144287
53Endometrial cancer_Homo sapiens_hsa052130.84602035
54Hematopoietic cell lineage_Homo sapiens_hsa046400.83871125
55ErbB signaling pathway_Homo sapiens_hsa040120.82679268
56Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.82482187
57Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.80873446
58Autoimmune thyroid disease_Homo sapiens_hsa053200.80062456
59Phosphatidylinositol signaling system_Homo sapiens_hsa040700.80011422
60Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.79344941
61RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78995123
62Sphingolipid signaling pathway_Homo sapiens_hsa040710.78876943
63* cAMP signaling pathway_Homo sapiens_hsa040240.76678003
64Chronic myeloid leukemia_Homo sapiens_hsa052200.76560322
65Hepatitis C_Homo sapiens_hsa051600.74672647
66Herpes simplex infection_Homo sapiens_hsa051680.74580779
67Acute myeloid leukemia_Homo sapiens_hsa052210.73554277
68MAPK signaling pathway_Homo sapiens_hsa040100.73274795
69Glioma_Homo sapiens_hsa052140.72838233
70Viral myocarditis_Homo sapiens_hsa054160.71848106
71Pertussis_Homo sapiens_hsa051330.70217019
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.69581326
73Inositol phosphate metabolism_Homo sapiens_hsa005620.69577557
74* Estrogen signaling pathway_Homo sapiens_hsa049150.67423473
75Ras signaling pathway_Homo sapiens_hsa040140.66750557
76Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66235368
77Gastric acid secretion_Homo sapiens_hsa049710.65560573
78* Cholinergic synapse_Homo sapiens_hsa047250.64173236
79GnRH signaling pathway_Homo sapiens_hsa049120.63789227
80Long-term depression_Homo sapiens_hsa047300.63076663
81Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.60713679
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60595315
83Circadian entrainment_Homo sapiens_hsa047130.59452906
84Endocytosis_Homo sapiens_hsa041440.59197895
85Salmonella infection_Homo sapiens_hsa051320.57222247
86Long-term potentiation_Homo sapiens_hsa047200.56628579
87Hedgehog signaling pathway_Homo sapiens_hsa043400.56183867
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.56164803
89VEGF signaling pathway_Homo sapiens_hsa043700.54595433
90Apoptosis_Homo sapiens_hsa042100.54568443
91* Prostate cancer_Homo sapiens_hsa052150.54350139
92* Dopaminergic synapse_Homo sapiens_hsa047280.53934880
93Type II diabetes mellitus_Homo sapiens_hsa049300.53342171
94GABAergic synapse_Homo sapiens_hsa047270.52491736
95Glutamatergic synapse_Homo sapiens_hsa047240.52427245
96mTOR signaling pathway_Homo sapiens_hsa041500.52384127
97Oxytocin signaling pathway_Homo sapiens_hsa049210.52060486
98Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50741181
99Circadian rhythm_Homo sapiens_hsa047100.49893150
100Type I diabetes mellitus_Homo sapiens_hsa049400.48915702

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