CREBBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)4.10884877
2negative regulation of cell killing (GO:0031342)4.03028012
3negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.03028012
4histone H3-K4 trimethylation (GO:0080182)3.95238650
5mitotic sister chromatid cohesion (GO:0007064)3.74087754
6negative regulation of erythrocyte differentiation (GO:0045647)3.73855645
7regulation of gamma-delta T cell activation (GO:0046643)3.61561196
8nuclear pore complex assembly (GO:0051292)3.57090168
9regulation of gamma-delta T cell differentiation (GO:0045586)3.51831811
10modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.51377435
11positive regulation by organism of defense response of other organism involved in symbiotic interact3.51377435
12modulation by symbiont of host immune response (GO:0052553)3.51377435
13positive regulation by symbiont of host defense response (GO:0052509)3.51377435
14modulation by symbiont of host defense response (GO:0052031)3.51377435
15modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.51377435
16response to muramyl dipeptide (GO:0032495)3.46951409
17kinetochore organization (GO:0051383)3.46096404
18kinetochore assembly (GO:0051382)3.43037888
19sister chromatid cohesion (GO:0007062)3.26685493
20piRNA metabolic process (GO:0034587)3.25423961
21regulation of NFAT protein import into nucleus (GO:0051532)3.23131104
22negative regulation of DNA-dependent DNA replication (GO:2000104)3.20928838
23negative thymic T cell selection (GO:0045060)3.18826181
24histone H3-K4 methylation (GO:0051568)3.18220312
25antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.16209379
26positive T cell selection (GO:0043368)3.12125265
27nuclear pore organization (GO:0006999)3.10386249
28macrophage activation involved in immune response (GO:0002281)3.09082498
29negative regulation of keratinocyte proliferation (GO:0010839)3.07825911
30antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.07451998
31thymic T cell selection (GO:0045061)3.06501334
32meiotic chromosome segregation (GO:0045132)3.05715979
33DNA methylation involved in gamete generation (GO:0043046)3.04061104
34leukocyte aggregation (GO:0070486)3.03972480
35negative T cell selection (GO:0043383)3.03877369
36positive thymic T cell selection (GO:0045059)3.03244820
37T cell selection (GO:0045058)2.99668372
38histone H3-K9 modification (GO:0061647)2.95841526
39positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.94717363
40regulation of nuclear cell cycle DNA replication (GO:0033262)2.94088522
41histone H3-K9 demethylation (GO:0033169)2.93730701
42phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.93572563
43cellular extravasation (GO:0045123)2.91972449
44regulation of DNA endoreduplication (GO:0032875)2.91083970
45pore complex assembly (GO:0046931)2.88908564
46regulation of B cell receptor signaling pathway (GO:0050855)2.87735823
47regulation of meiosis I (GO:0060631)2.86479059
48positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.86455590
49positive regulation of male gonad development (GO:2000020)2.86045558
50antigen processing and presentation of endogenous antigen (GO:0019883)2.83753794
51regulation of male gonad development (GO:2000018)2.83608157
52antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.83080465
53detection of other organism (GO:0098543)2.82795977
54peptidyl-lysine trimethylation (GO:0018023)2.79850478
55microtubule depolymerization (GO:0007019)2.78492192
56response to laminar fluid shear stress (GO:0034616)2.78237141
57regulation of histone H3-K27 methylation (GO:0061085)2.77338965
58tolerance induction (GO:0002507)2.77088298
59negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.76367375
60negative regulation of translation, ncRNA-mediated (GO:0040033)2.76367375
61regulation of translation, ncRNA-mediated (GO:0045974)2.76367375
62response to interleukin-15 (GO:0070672)2.74085935
63regulation of ARF protein signal transduction (GO:0032012)2.72566423
64mesenchymal cell differentiation involved in kidney development (GO:0072161)2.68348726
65mesenchymal cell differentiation involved in renal system development (GO:2001012)2.68348726
66regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.67564202
67regulation of mitotic spindle checkpoint (GO:1903504)2.67564202
68positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.67528970
69protein demethylation (GO:0006482)2.67269007
70protein dealkylation (GO:0008214)2.67269007
713-UTR-mediated mRNA stabilization (GO:0070935)2.66276091
72detection of bacterium (GO:0016045)2.65115973
73detection of molecule of bacterial origin (GO:0032490)2.63364369
74histone H3-K9 methylation (GO:0051567)2.61597516
75germinal center formation (GO:0002467)2.61540926
76positive regulation of histone deacetylation (GO:0031065)2.61444885
77DNA synthesis involved in DNA repair (GO:0000731)2.61336182
78B cell receptor signaling pathway (GO:0050853)2.61074031
79activated T cell proliferation (GO:0050798)2.59963598
80negative regulation of cAMP-mediated signaling (GO:0043951)2.58576244
81embryonic process involved in female pregnancy (GO:0060136)2.58379315
82response to peptidoglycan (GO:0032494)2.56207892
83positive regulation of Rap GTPase activity (GO:0032854)2.55978058
84DNA double-strand break processing (GO:0000729)2.55507071
85negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.54812270
86negative regulation of myotube differentiation (GO:0010832)2.50983117
87mannose metabolic process (GO:0006013)2.50464316
88positive regulation of meiosis (GO:0045836)2.50098002
89negative regulation of T cell mediated immunity (GO:0002710)2.50066427
90histone H4-K16 acetylation (GO:0043984)2.49618096
91cell differentiation involved in metanephros development (GO:0072202)2.49284852
92poly(A)+ mRNA export from nucleus (GO:0016973)2.48595959
93detection of external biotic stimulus (GO:0098581)2.48093417
94positive regulation of CREB transcription factor activity (GO:0032793)2.48042369
95cytoplasmic mRNA processing body assembly (GO:0033962)2.47863047
96negative regulation of histone methylation (GO:0031061)2.47646670
97replication fork processing (GO:0031297)2.47600849
98insulin-like growth factor receptor signaling pathway (GO:0048009)2.47029345
99negative regulation of lymphocyte mediated immunity (GO:0002707)2.46880566
100metaphase plate congression (GO:0051310)2.46647169
101response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.46555777
102response to host (GO:0075136)2.46555777
103response to host defenses (GO:0052200)2.46555777
104mitotic metaphase plate congression (GO:0007080)2.45165569
105histone lysine methylation (GO:0034968)2.44653501
106DNA methylation (GO:0006306)2.43869002
107DNA alkylation (GO:0006305)2.43869002
108regulation of ARF GTPase activity (GO:0032312)2.43624370
109intracellular estrogen receptor signaling pathway (GO:0030520)2.43369670
110histone H2A acetylation (GO:0043968)2.42825485
111negative regulation of stem cell proliferation (GO:2000647)2.42566848
112regulation of interferon-beta biosynthetic process (GO:0045357)2.40290785
113protein localization to microtubule cytoskeleton (GO:0072698)2.39507258
114male meiosis (GO:0007140)2.38841006
115neural tube formation (GO:0001841)2.37481926
116interkinetic nuclear migration (GO:0022027)2.36922043
117regulation of T-helper 2 cell differentiation (GO:0045628)2.36224453
118regulation of RNA export from nucleus (GO:0046831)2.36139470
119glomerulus development (GO:0032835)2.36101252
120response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.36089632
121response to host immune response (GO:0052572)2.36089632
122negative regulation of glial cell proliferation (GO:0060253)2.34088037
123negative regulation of toll-like receptor signaling pathway (GO:0034122)2.33573139
124negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.32140898
125positive regulation of granulocyte differentiation (GO:0030854)2.32012192
126positive regulation of protein deacetylation (GO:0090312)2.31757610
127cell differentiation involved in kidney development (GO:0061005)2.31632401
128positive regulation of gene expression, epigenetic (GO:0045815)2.31299851
129positive regulation of meiotic cell cycle (GO:0051446)2.31282705
130regulation of telomere maintenance (GO:0032204)2.31036581
131regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.30973377
132histone H3-K36 demethylation (GO:0070544)2.29831309
133protein K11-linked deubiquitination (GO:0035871)2.29782603
134negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)2.29306415
135positive regulation of mRNA processing (GO:0050685)2.29019262
136pericardium development (GO:0060039)2.28201799
137peptidyl-lysine methylation (GO:0018022)2.28091284
138embryonic camera-type eye morphogenesis (GO:0048596)2.27933190
139negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.27698940
140negative regulation of T-helper cell differentiation (GO:0045623)2.27698940
141monoubiquitinated protein deubiquitination (GO:0035520)2.27148503
142positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.27034071
143regulation of interleukin-12 biosynthetic process (GO:0045075)2.25571200
144limb bud formation (GO:0060174)2.25402559
145pre-miRNA processing (GO:0031054)2.24891771
146regulation of keratinocyte proliferation (GO:0010837)2.24363181
147smooth muscle tissue development (GO:0048745)2.24334772
148regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.23803521
149cellular response to interleukin-15 (GO:0071350)2.23759806
150embryonic digestive tract morphogenesis (GO:0048557)2.22856205
151definitive hemopoiesis (GO:0060216)2.21036957
152sympathetic nervous system development (GO:0048485)2.19054240
153maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.18531185
154DNA methylation or demethylation (GO:0044728)2.17938087
155histone demethylation (GO:0016577)2.17905803
156histone lysine demethylation (GO:0070076)2.17375550
157mRNA splice site selection (GO:0006376)2.16934031
158negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)2.16209450
159positive regulation of DNA-dependent DNA replication (GO:2000105)2.16072809
160establishment of chromosome localization (GO:0051303)2.15824003
161cell proliferation in forebrain (GO:0021846)2.15633209
162kidney morphogenesis (GO:0060993)2.15071429
163female gonad development (GO:0008585)2.14786213
164replicative senescence (GO:0090399)2.14163711
165dentate gyrus development (GO:0021542)2.13508833
166appendage development (GO:0048736)2.13182798
167limb development (GO:0060173)2.13182798
168spindle checkpoint (GO:0031577)2.12630040
169regulation of transcription from RNA polymerase I promoter (GO:0006356)2.12488024
170regulation of non-canonical Wnt signaling pathway (GO:2000050)2.11520786
171reciprocal DNA recombination (GO:0035825)2.11395594
172reciprocal meiotic recombination (GO:0007131)2.11395594
173resolution of meiotic recombination intermediates (GO:0000712)2.11339107
174paraxial mesoderm development (GO:0048339)2.10769535
175regulation of mRNA splicing, via spliceosome (GO:0048024)2.10026098
176regulation of gene expression by genetic imprinting (GO:0006349)2.09937608
177negative regulation of signal transduction by p53 class mediator (GO:1901797)2.09933715
178positive regulation of mRNA metabolic process (GO:1903313)2.09767446
179regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.09578910
180positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.09578910
181protein localization to cytoskeleton (GO:0044380)2.09396393
182positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.08369134
183centriole replication (GO:0007099)2.08122868
184mesenchymal cell differentiation (GO:0048762)2.07819684
185positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.07426574
186regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.07426574
187oocyte maturation (GO:0001556)2.07415850
188negative regulation of mast cell activation (GO:0033004)2.06739156
189myoblast migration (GO:0051451)2.06468385

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1RBPJ_22232070_ChIP-Seq_NCS_Mouse3.75869103
2SALL1_21062744_ChIP-ChIP_HESCs_Human3.31415677
3TP63_19390658_ChIP-ChIP_HaCaT_Human3.29437946
4E2F7_22180533_ChIP-Seq_HELA_Human3.26915172
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.07603752
6MYC_22102868_ChIP-Seq_BL_Human3.02283945
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.01766249
8STAT6_21828071_ChIP-Seq_BEAS2B_Human2.98099936
9KDM2B_26808549_Chip-Seq_SUP-B15_Human2.91608857
10CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.87157861
11SMAD_19615063_ChIP-ChIP_OVARY_Human2.86040697
12* TCF7_22412390_ChIP-Seq_EML_Mouse2.82231165
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.79830891
14GBX2_23144817_ChIP-Seq_PC3_Human2.78872137
15VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.78323479
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.73177326
17KDM2B_26808549_Chip-Seq_DND41_Human2.58391467
18KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.50318351
19KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.42917800
20POU3F2_20337985_ChIP-ChIP_501MEL_Human2.39020667
21VDR_21846776_ChIP-Seq_THP-1_Human2.37744316
22FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.37565994
23RUNX_20019798_ChIP-Seq_JUKART_Human2.33149779
24FUS_26573619_Chip-Seq_HEK293_Human2.30051155
25ZFP57_27257070_Chip-Seq_ESCs_Mouse2.24038413
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.22159374
27* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.20343771
28* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.15661546
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.15270552
30KDM2B_26808549_Chip-Seq_JURKAT_Human2.14126977
31EWS_26573619_Chip-Seq_HEK293_Human2.12627956
32PCGF2_27294783_Chip-Seq_ESCs_Mouse2.06619396
33SCL_19346495_ChIP-Seq_HPC-7_Human2.06121879
34VDR_24763502_ChIP-Seq_THP-1_Human2.05469027
35IRF8_22096565_ChIP-ChIP_GC-B_Human1.98257712
36* KDM2B_26808549_Chip-Seq_K562_Human1.96180081
37* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.95440559
38SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.93046690
39MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.92983888
40P300_19829295_ChIP-Seq_ESCs_Human1.85790980
41MAF_26560356_Chip-Seq_TH1_Human1.84776209
42POU5F1_16153702_ChIP-ChIP_HESCs_Human1.84577128
43* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.77274294
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.75022218
45TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.73060969
46RNF2_27304074_Chip-Seq_NSC_Mouse1.71345956
47UTX_26944678_Chip-Seq_JUKART_Human1.69785313
48IGF1R_20145208_ChIP-Seq_DFB_Human1.69452084
49THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67581641
50DROSHA_22980978_ChIP-Seq_HELA_Human1.67159249
51ELK3_25401928_ChIP-Seq_HUVEC_Human1.67158327
52* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.67100620
53TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.65781716
54E2F4_17652178_ChIP-ChIP_JURKAT_Human1.65780112
55GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.65662658
56SPI1_23127762_ChIP-Seq_K562_Human1.64993652
57STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.63555287
58MYB_21317192_ChIP-Seq_ERMYB_Mouse1.62697175
59SMAD4_21799915_ChIP-Seq_A2780_Human1.62303890
60NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61883915
61SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.61374701
62ZFP281_27345836_Chip-Seq_ESCs_Mouse1.60816675
63NANOG_18555785_Chip-Seq_ESCs_Mouse1.60614656
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58949491
65BP1_19119308_ChIP-ChIP_Hs578T_Human1.58946332
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.57550480
67* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.55730884
68SUZ12_27294783_Chip-Seq_NPCs_Mouse1.54516345
69AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.53906882
70GATA1_19941827_ChIP-Seq_MEL_Mouse1.53015413
71BMI1_23680149_ChIP-Seq_NPCS_Mouse1.52707513
72IRF8_27001747_Chip-Seq_BMDM_Mouse1.52312538
73TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.51253176
74MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.50794867
75STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.50690142
76MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.50055900
77E2F1_18555785_Chip-Seq_ESCs_Mouse1.49671621
78* TAF15_26573619_Chip-Seq_HEK293_Human1.48372233
79ESR2_21235772_ChIP-Seq_MCF-7_Human1.45388320
80CBX2_27304074_Chip-Seq_ESCs_Mouse1.44821030
81NFE2_27457419_Chip-Seq_LIVER_Mouse1.44726201
82NOTCH1_21737748_ChIP-Seq_TLL_Human1.44381953
83RUNX1_22412390_ChIP-Seq_EML_Mouse1.44214641
84YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.42583847
85BRD4_27068464_Chip-Seq_AML-cells_Mouse1.42573410
86TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.42271537
87PCGF2_27294783_Chip-Seq_NPCs_Mouse1.40686278
88EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.40402649
89MYB_26560356_Chip-Seq_TH1_Human1.39879480
90ZNF217_24962896_ChIP-Seq_MCF-7_Human1.39184252
91WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.37976064
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.37333586
93POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.37333586
94MAF_26560356_Chip-Seq_TH2_Human1.36462158
95MYB_26560356_Chip-Seq_TH2_Human1.36109734
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34883770
97EZH2_27294783_Chip-Seq_NPCs_Mouse1.33324331
98SUZ12_18555785_Chip-Seq_ESCs_Mouse1.33065056
99P53_22387025_ChIP-Seq_ESCs_Mouse1.32772175
100VDR_24787735_ChIP-Seq_THP-1_Human1.32053592
101TCF4_18268006_ChIP-ChIP_LS174T_Human1.31420846
102PIAS1_25552417_ChIP-Seq_VCAP_Human1.30864770
103RUNX1_27514584_Chip-Seq_MCF-7_Human1.30690996
104STAT3_23295773_ChIP-Seq_U87_Human1.30202885
105TCF4_23295773_ChIP-Seq_U87_Human1.29445935
106LXR_22292898_ChIP-Seq_THP-1_Human1.28608871
107NFIB_24661679_ChIP-Seq_LUNG_Mouse1.26762767
108STAT3_18555785_Chip-Seq_ESCs_Mouse1.25000021
109ER_23166858_ChIP-Seq_MCF-7_Human1.24837210
110SOX9_24532713_ChIP-Seq_HFSC_Mouse1.23475009
111ESR1_20079471_ChIP-ChIP_T-47D_Human1.22789457
112* GATA1_19941826_ChIP-Seq_K562_Human1.22366868
113CMYC_18555785_Chip-Seq_ESCs_Mouse1.22149029
114CTBP2_25329375_ChIP-Seq_LNCAP_Human1.21780429
115SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.21462038
116VDR_22108803_ChIP-Seq_LS180_Human1.21269235
117ARNT_22903824_ChIP-Seq_MCF-7_Human1.20597835
118TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.19083482
119ZFP281_18757296_ChIP-ChIP_E14_Mouse1.18239621
120EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.18231455
121KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.17209439
122KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.17209439
123KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.17209439
124EZH2_22144423_ChIP-Seq_EOC_Human1.16338023
125TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.15810430
126* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.15633015
127NMYC_18555785_Chip-Seq_ESCs_Mouse1.15537149
128SOX9_26525672_Chip-Seq_HEART_Mouse1.15511329
129FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.15056152
130* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.15017991
131SMAD3_21741376_ChIP-Seq_EPCs_Human1.14956883
132* RACK7_27058665_Chip-Seq_MCF-7_Human1.14527796
133OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13688987
134CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12980126
135STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.12269058
136GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.12133244
137P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11741161
138AHR_22903824_ChIP-Seq_MCF-7_Human1.11143374
139LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11036094
140HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.10949059
141TOP2B_26459242_ChIP-Seq_MCF-7_Human1.10443725
142SOX2_18555785_Chip-Seq_ESCs_Mouse1.10421319
143PKCTHETA_26484144_Chip-Seq_BREAST_Human1.10083503
144OCT4_18555785_Chip-Seq_ESCs_Mouse1.09043398
145TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.08624781
146CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.08160834
147CREB1_26743006_Chip-Seq_LNCaP_Human1.07988384
148P300_18555785_Chip-Seq_ESCs_Mouse1.06824478
149FOXO3_23340844_ChIP-Seq_DLD1_Human1.06406859
150TP53_18474530_ChIP-ChIP_U2OS_Human1.06150105
151* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.05071212
152TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.04480976
153FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.04203021
154GATA3_27048872_Chip-Seq_THYMUS_Human1.02893499
155RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.02582611
156NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01879735
157CTBP1_25329375_ChIP-Seq_LNCAP_Human1.01303529
158P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00794681
159RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.00584852
160IRF8_21731497_ChIP-ChIP_J774_Mouse1.00252134
161ZFX_18555785_Chip-Seq_ESCs_Mouse0.99629893
162FOXM1_23109430_ChIP-Seq_U2OS_Human0.99162870
163UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.98378602
164FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98353713
165NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.97711044
166RUNX2_22187159_ChIP-Seq_PCA_Human0.97407265
167PRDM14_20953172_ChIP-Seq_ESCs_Human0.97377025
168AR_25329375_ChIP-Seq_VCAP_Human0.97066948
169E2F1_21310950_ChIP-Seq_MCF-7_Human0.96396839
170* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.96018393
171RUNX1_27457419_Chip-Seq_LIVER_Mouse0.95928936
172NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.95617651
173* RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.95500947
174LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.95169375
175KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.94665644
176GATA1_19941827_ChIP-Seq_MEL86_Mouse0.94397329
177ELK1_19687146_ChIP-ChIP_HELA_Human0.94148908
178GATA1_22025678_ChIP-Seq_K562_Human0.93975852
179ISL1_27105846_Chip-Seq_CPCs_Mouse0.91984323
180KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.91647319
181FOXA2_19822575_ChIP-Seq_HepG2_Human0.91317759
182IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.90953233
183SMC4_20622854_ChIP-Seq_HELA_Human0.90851693
184WT1_25993318_ChIP-Seq_PODOCYTE_Human0.89753391
185* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.89078451
186PU_27001747_Chip-Seq_BMDM_Mouse0.88002192
187* GATA2_19941826_ChIP-Seq_K562_Human0.86864286
188RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.86135936
189TBX20_22080862_ChIP-Seq_HEART_Mouse0.85907162
190TBX20_22328084_ChIP-Seq_HEART_Mouse0.85907162

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.97263576
2MP0008877_abnormal_DNA_methylation3.91636799
3MP0000566_synostosis3.58925902
4MP0009278_abnormal_bone_marrow3.14256726
5MP0003436_decreased_susceptibility_to2.96378939
6MP0006292_abnormal_olfactory_placode2.93676425
7MP0001188_hyperpigmentation2.75831786
8MP0003121_genomic_imprinting2.70947014
9MP0008057_abnormal_DNA_replication2.69510755
10MP0003705_abnormal_hypodermis_morpholog2.61885774
11MP0003303_peritoneal_inflammation2.61024459
12MP0003941_abnormal_skin_development2.59988323
13MP0003724_increased_susceptibility_to2.38273817
14MP0003300_gastrointestinal_ulcer2.37978501
15MP0004381_abnormal_hair_follicle2.10712039
16MP0001800_abnormal_humoral_immune2.07408261
17MP0008058_abnormal_DNA_repair1.94897367
18MP0000685_abnormal_immune_system1.93551615
19MP0004947_skin_inflammation1.90822676
20MP0003091_abnormal_cell_migration1.90754413
21MP0002163_abnormal_gland_morphology1.86099789
22MP0010094_abnormal_chromosome_stability1.85419613
23MP0001835_abnormal_antigen_presentation1.83641939
24* MP0000703_abnormal_thymus_morphology1.77376285
25MP0005387_immune_system_phenotype1.76257061
26MP0001790_abnormal_immune_system1.76257061
27MP0003122_maternal_imprinting1.75299998
28MP0003385_abnormal_body_wall1.74678664
29MP0003172_abnormal_lysosome_physiology1.73010660
30MP0003123_paternal_imprinting1.71862829
31MP0004264_abnormal_extraembryonic_tissu1.69549383
32MP0002405_respiratory_system_inflammati1.66811797
33MP0002166_altered_tumor_susceptibility1.65677091
34MP0005000_abnormal_immune_tolerance1.65650422
35MP0008007_abnormal_cellular_replicative1.64813042
36MP0002938_white_spotting1.64511877
37* MP0002398_abnormal_bone_marrow1.63797732
38MP0002420_abnormal_adaptive_immunity1.63565603
39MP0002419_abnormal_innate_immunity1.63381600
40MP0008995_early_reproductive_senescence1.63004113
41MP0003045_fibrosis1.62784964
42MP0008260_abnormal_autophagy1.61960665
43MP0005409_darkened_coat_color1.60472660
44MP0001819_abnormal_immune_cell1.60379599
45MP0008961_abnormal_basal_metabolism1.59785365
46MP0003786_premature_aging1.57432213
47MP0002009_preneoplasia1.57396128
48MP0003183_abnormal_peptide_metabolism1.57121101
49* MP0002723_abnormal_immune_serum1.55903938
50MP0005025_abnormal_response_to1.53377258
51MP0008789_abnormal_olfactory_epithelium1.52820470
52MP0002396_abnormal_hematopoietic_system1.50941755
53MP0002452_abnormal_antigen_presenting1.50895140
54MP0001851_eye_inflammation1.50144359
55MP0002998_abnormal_bone_remodeling1.49470845
56MP0009250_abnormal_appendicular_skeleto1.49340882
57MP0000569_abnormal_digit_pigmentation1.47719060
58MP0005397_hematopoietic_system_phenotyp1.46313092
59MP0001545_abnormal_hematopoietic_system1.46313092
60MP0005171_absent_coat_pigmentation1.45265043
61MP0004130_abnormal_muscle_cell1.44975252
62MP0001533_abnormal_skeleton_physiology1.43192521
63MP0003890_abnormal_embryonic-extraembry1.42110835
64MP0000015_abnormal_ear_pigmentation1.41820683
65MP0005503_abnormal_tendon_morphology1.41278004
66* MP0000716_abnormal_immune_system1.39363747
67* MP0003755_abnormal_palate_morphology1.37867142
68MP0009697_abnormal_copulation1.37465076
69MP0005451_abnormal_body_composition1.35836290
70MP0010030_abnormal_orbit_morphology1.35322938
71MP0003111_abnormal_nucleus_morphology1.35031250
72MP0005646_abnormal_pituitary_gland1.33691523
73MP0005394_taste/olfaction_phenotype1.33668893
74MP0005499_abnormal_olfactory_system1.33668893
75MP0000516_abnormal_urinary_system1.33026825
76MP0005367_renal/urinary_system_phenotyp1.33026825
77MP0004510_myositis1.32690561
78MP0005671_abnormal_response_to1.31979805
79MP0003077_abnormal_cell_cycle1.28066097
80MP0003943_abnormal_hepatobiliary_system1.27731188
81MP0000049_abnormal_middle_ear1.26981449
82MP0001119_abnormal_female_reproductive1.26408863
83MP0001348_abnormal_lacrimal_gland1.25036819
84MP0004808_abnormal_hematopoietic_stem1.23153713
85MP0003866_abnormal_defecation1.23023098
86MP0001873_stomach_inflammation1.22599163
87MP0009333_abnormal_splenocyte_physiolog1.21140521
88* MP0002722_abnormal_immune_system1.21007883
89MP0001879_abnormal_lymphatic_vessel1.20211112
90MP0002249_abnormal_larynx_morphology1.17705754
91MP0003937_abnormal_limbs/digits/tail_de1.17467451
92MP0002210_abnormal_sex_determination1.16932545
93MP0003453_abnormal_keratinocyte_physiol1.16429994
94MP0005248_abnormal_Harderian_gland1.14944511
95MP0010155_abnormal_intestine_physiology1.14909592
96MP0003279_aneurysm1.13169885
97MP0000733_abnormal_muscle_development1.11644641
98MP0002277_abnormal_respiratory_mucosa1.09194305
99MP0003935_abnormal_craniofacial_develop1.09067818
100MP0003942_abnormal_urinary_system1.08040456
101MP0003191_abnormal_cellular_cholesterol1.07459096
102* MP0000689_abnormal_spleen_morphology1.06680104
103MP0004185_abnormal_adipocyte_glucose1.06419034
104MP0003566_abnormal_cell_adhesion1.05738985
105MP0001958_emphysema1.05244752
106MP0004883_abnormal_blood_vessel1.04893172
107* MP0000432_abnormal_head_morphology1.04537609
108* MP0002116_abnormal_craniofacial_bone1.03993530
109MP0008004_abnormal_stomach_pH1.03911092
110MP0001286_abnormal_eye_development1.03877879
111MP0002876_abnormal_thyroid_physiology1.03624960
112MP0005379_endocrine/exocrine_gland_phen1.03252892
113* MP0002429_abnormal_blood_cell1.02902824
114MP0002751_abnormal_autonomic_nervous1.00298133
115MP0003115_abnormal_respiratory_system0.99868678
116MP0000470_abnormal_stomach_morphology0.98384086
117MP0001177_atelectasis0.98224482
118MP0001346_abnormal_lacrimal_gland0.98008001
119MP0003693_abnormal_embryo_hatching0.96583874
120MP0004858_abnormal_nervous_system0.96577926
121* MP0002109_abnormal_limb_morphology0.96531317
122MP0002177_abnormal_outer_ear0.95850160
123MP0002160_abnormal_reproductive_system0.94669863
124MP0002933_joint_inflammation0.94608785
125MP0001919_abnormal_reproductive_system0.94372778
126MP0005666_abnormal_adipose_tissue0.94142947
127MP0002095_abnormal_skin_pigmentation0.92460243
128* MP0009115_abnormal_fat_cell0.91189460
129MP0010630_abnormal_cardiac_muscle0.91123745
130MP0000678_abnormal_parathyroid_gland0.90870139
131MP0002233_abnormal_nose_morphology0.90795466
132MP0005508_abnormal_skeleton_morphology0.86852755
133MP0005390_skeleton_phenotype0.85955018
134MP0005389_reproductive_system_phenotype0.85042676
135MP0003690_abnormal_glial_cell0.84014377
136MP0003763_abnormal_thymus_physiology0.84000555
137MP0003938_abnormal_ear_development0.83991049
138MP0000653_abnormal_sex_gland0.83674411
139MP0004134_abnormal_chest_morphology0.82747589
140* MP0002925_abnormal_cardiovascular_devel0.81794432
141MP0000631_abnormal_neuroendocrine_gland0.80439049
142MP0001849_ear_inflammation0.80224906
143MP0009053_abnormal_anal_canal0.79018262
144MP0004233_abnormal_muscle_weight0.78776677
145* MP0005621_abnormal_cell_physiology0.77259086
146MP0005375_adipose_tissue_phenotype0.76761418
147MP0001784_abnormal_fluid_regulation0.76717846
148MP0008932_abnormal_embryonic_tissue0.76700898
149MP0010368_abnormal_lymphatic_system0.75875400
150MP0009703_decreased_birth_body0.75731715
151MP0001293_anophthalmia0.75700042
152MP0002108_abnormal_muscle_morphology0.74642343
153MP0001145_abnormal_male_reproductive0.74585239
154MP0005377_hearing/vestibular/ear_phenot0.73467150
155MP0003878_abnormal_ear_physiology0.73467150
156MP0000778_abnormal_nervous_system0.73275871
157MP0002138_abnormal_hepatobiliary_system0.72825717
158MP0001986_abnormal_taste_sensitivity0.72571376
159MP0003315_abnormal_perineum_morphology0.71923272
160MP0000767_abnormal_smooth_muscle0.71025182
161MP0003936_abnormal_reproductive_system0.70806023
162* MP0002114_abnormal_axial_skeleton0.70585202
163MP0001929_abnormal_gametogenesis0.69887481
164MP0000427_abnormal_hair_cycle0.69814776
165MP0000350_abnormal_cell_proliferation0.69737953
166MP0003828_pulmonary_edema0.69468489
167MP0005076_abnormal_cell_differentiation0.68473664
168MP0005075_abnormal_melanosome_morpholog0.68223501
169MP0010352_gastrointestinal_tract_polyps0.68019794
170MP0000858_altered_metastatic_potential0.67832346
171MP0002088_abnormal_embryonic_growth/wei0.67664247
172MP0006138_congestive_heart_failure0.67385462
173MP0005408_hypopigmentation0.67161084
174MP0005310_abnormal_salivary_gland0.66821833
175MP0002133_abnormal_respiratory_system0.66662455
176MP0005388_respiratory_system_phenotype0.66662455
177MP0002006_tumorigenesis0.64757491
178* MP0001672_abnormal_embryogenesis/_devel0.64648636
179* MP0005380_embryogenesis_phenotype0.64648636
180MP0005174_abnormal_tail_pigmentation0.63758165
181MP0001845_abnormal_inflammatory_respons0.63119239
182MP0006082_CNS_inflammation0.62470318
183MP0003656_abnormal_erythrocyte_physiolo0.62236062

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.68920393
2Chromsome breakage (HP:0040012)3.63909803
3Chromosomal breakage induced by crosslinking agents (HP:0003221)3.37788454
4Lip pit (HP:0100267)3.26226807
5Volvulus (HP:0002580)3.22720713
6Ectopic kidney (HP:0000086)3.17457623
7Papillary thyroid carcinoma (HP:0002895)2.92052121
8Broad face (HP:0000283)2.91459121
9* Obstructive sleep apnea (HP:0002870)2.86218154
10Short 4th metacarpal (HP:0010044)2.80702616
11Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.80702616
12Nephroblastoma (Wilms tumor) (HP:0002667)2.70580580
13Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.67559867
14Abnormality of the labia minora (HP:0012880)2.62414515
15Midline defect of the nose (HP:0004122)2.60949675
16Spontaneous hematomas (HP:0007420)2.59897226
17Embryonal renal neoplasm (HP:0011794)2.57224845
18Recurrent bacterial skin infections (HP:0005406)2.54191914
19* Abnormality of the fingertips (HP:0001211)2.53283799
20Deep philtrum (HP:0002002)2.52770851
21Prostate neoplasm (HP:0100787)2.51861721
22Cerebral aneurysm (HP:0004944)2.51464935
23Gingivitis (HP:0000230)2.50129752
24* Narrow palate (HP:0000189)2.45997899
25True hermaphroditism (HP:0010459)2.43807366
26Increased IgE level (HP:0003212)2.41719395
27Syringomyelia (HP:0003396)2.41708093
28Spinal cord lesions (HP:0100561)2.41708093
29Hepatoblastoma (HP:0002884)2.41412587
30Myositis (HP:0100614)2.39177118
31Abnormality of the intervertebral disk (HP:0005108)2.37306552
32Patellar aplasia (HP:0006443)2.35715004
33* Long eyelashes (HP:0000527)2.32919178
34Meckel diverticulum (HP:0002245)2.32243580
35Neoplasm of the adrenal cortex (HP:0100641)2.31826674
36Recurrent abscess formation (HP:0002722)2.29632448
37Macroorchidism (HP:0000053)2.28947469
38Urethral obstruction (HP:0000796)2.28699027
39Adrenal hypoplasia (HP:0000835)2.28355779
40Febrile seizures (HP:0002373)2.25681874
41Orchitis (HP:0100796)2.25476667
42Aplasia/Hypoplasia of the sternum (HP:0006714)2.25144057
43Acute myeloid leukemia (HP:0004808)2.24865223
44Heterotopia (HP:0002282)2.24684560
45Abnormal delayed hypersensitivity skin test (HP:0002963)2.24190517
46Recurrent fungal infections (HP:0002841)2.22414624
47Trigonocephaly (HP:0000243)2.20831299
48Chronic hepatic failure (HP:0100626)2.19787788
49Aplasia/Hypoplasia of the patella (HP:0006498)2.17386815
50Abnormality of the ileum (HP:0001549)2.16495706
51Gastrointestinal infarctions (HP:0005244)2.16346873
52Hypoplastic labia majora (HP:0000059)2.15125718
53Pancreatic fibrosis (HP:0100732)2.15003256
54Absent eyebrow (HP:0002223)2.14076703
55Germ cell neoplasia (HP:0100728)2.13521679
56Cellulitis (HP:0100658)2.12297040
57Supernumerary ribs (HP:0005815)2.12124781
58* Abnormality of incisor morphology (HP:0011063)2.11603474
59Aplasia/Hypoplasia of the uvula (HP:0010293)2.11599057
60Absent frontal sinuses (HP:0002688)2.11454258
61Increased number of teeth (HP:0011069)2.10847222
62Aortic aneurysm (HP:0004942)2.10808185
63T lymphocytopenia (HP:0005403)2.10283254
64Vertebral arch anomaly (HP:0008438)2.07824419
65Abnormality of chromosome stability (HP:0003220)2.07646660
66Neonatal hypoglycemia (HP:0001998)2.07123450
67* Abnormality of the incisor (HP:0000676)2.06618024
68Persistence of primary teeth (HP:0006335)2.06568029
69Subacute progressive viral hepatitis (HP:0006572)2.06272607
70Abnormal lung lobation (HP:0002101)2.04421810
71Mitral valve prolapse (HP:0001634)2.04156102
72Optic nerve coloboma (HP:0000588)2.03066252
73Shallow orbits (HP:0000586)2.02698762
74Intestinal fistula (HP:0100819)2.02502142
75Peritonitis (HP:0002586)2.00095924
76Supernumerary bones of the axial skeleton (HP:0009144)1.97895984
77Facial hemangioma (HP:0000329)1.97435650
78Stomach cancer (HP:0012126)1.96147621
79Abnormality of the labia majora (HP:0012881)1.95990604
80Pustule (HP:0200039)1.95560635
81Submucous cleft hard palate (HP:0000176)1.95120350
82Long clavicles (HP:0000890)1.94923184
83Aneurysm (HP:0002617)1.94163300
84Preaxial hand polydactyly (HP:0001177)1.93904145
85Clubbing of toes (HP:0100760)1.93863072
86Thyroid carcinoma (HP:0002890)1.93104840
87* Truncal obesity (HP:0001956)1.92509781
88Stomatitis (HP:0010280)1.91157395
89Abnormality of the preputium (HP:0100587)1.91064342
90Renal hypoplasia (HP:0000089)1.90856534
91Dysmetric saccades (HP:0000641)1.89204388
92Colitis (HP:0002583)1.88545550
93* Abnormal hair whorl (HP:0010721)1.87894768
94Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.86779077
95Sparse lateral eyebrow (HP:0005338)1.85834519
96Slow saccadic eye movements (HP:0000514)1.85570228
97Recurrent cutaneous fungal infections (HP:0011370)1.85564684
98Chronic mucocutaneous candidiasis (HP:0002728)1.85564684
99Acute lymphatic leukemia (HP:0006721)1.85496603
100Disproportionate tall stature (HP:0001519)1.85256936
101Mediastinal lymphadenopathy (HP:0100721)1.85197493
102Birth length less than 3rd percentile (HP:0003561)1.83831531
103Flat capital femoral epiphysis (HP:0003370)1.83102883
104Hyperacusis (HP:0010780)1.82302752
105Abnormality of T cell number (HP:0011839)1.81630159
106Meningitis (HP:0001287)1.81319182
107Diastasis recti (HP:0001540)1.80642055
108Deep palmar crease (HP:0006191)1.80570472
109Tubulointerstitial nephritis (HP:0001970)1.80403967
110Embryonal neoplasm (HP:0002898)1.79495009
111Depressed nasal tip (HP:0000437)1.79271464
112Overgrowth (HP:0001548)1.78360602
113Gastrointestinal inflammation (HP:0004386)1.78316015
114Segmental peripheral demyelination/remyelination (HP:0003481)1.77584991
115Papilledema (HP:0001085)1.76620811
116Morphological abnormality of the middle ear (HP:0008609)1.76124462
117Flat acetabular roof (HP:0003180)1.75141027
118* Dislocated radial head (HP:0003083)1.75070416
119Metaphyseal cupping (HP:0003021)1.74780205
120Neoplasm of the heart (HP:0100544)1.74473802
121Protruding tongue (HP:0010808)1.73948567
122Pancreatic cysts (HP:0001737)1.73879361
123Prolonged bleeding time (HP:0003010)1.73440082
124Keratoconjunctivitis sicca (HP:0001097)1.72806657
125Abnormal number of incisors (HP:0011064)1.72736065
126Short middle phalanx of the 5th finger (HP:0004220)1.71893183
127Tapered finger (HP:0001182)1.71855267
128Recurrent skin infections (HP:0001581)1.71101446
129Difficulty running (HP:0009046)1.71026797
130Onion bulb formation (HP:0003383)1.70875798
131Abnormality of the metopic suture (HP:0005556)1.70860669
132Inflammation of the large intestine (HP:0002037)1.70289321
133Bicuspid aortic valve (HP:0001647)1.70237083
134Anal stenosis (HP:0002025)1.69681299
135Viral hepatitis (HP:0006562)1.68350418
136Preauricular pit (HP:0004467)1.68261786
137Periauricular skin pits (HP:0100277)1.68261786
138Growth hormone deficiency (HP:0000824)1.67856894
139Recurrent viral infections (HP:0004429)1.67752870
140Aplasia/Hypoplasia of the tongue (HP:0010295)1.67021010
141Recurrent gram-negative bacterial infections (HP:0005420)1.66192703
142Abnormality of macrophages (HP:0004311)1.66025250
143Optic neuritis (HP:0100653)1.65821319
144Retrobulbar optic neuritis (HP:0100654)1.65821319
145Prominent nose (HP:0000448)1.64394728
146Abnormality of the left ventricular outflow tract (HP:0011103)1.63860622
147Subaortic stenosis (HP:0001682)1.63860622
148Genetic anticipation (HP:0003743)1.63219033
149Renal dysplasia (HP:0000110)1.63189890
150* Abnormality of the radial head (HP:0003995)1.61348259
151Broad palm (HP:0001169)1.61231022
152Oligodactyly (HP:0012165)1.60626572
153Slow-growing hair (HP:0002217)1.60616373
154Abnormality of hair growth rate (HP:0011363)1.60616373
155Spondylolisthesis (HP:0003302)1.60566853
156White forelock (HP:0002211)1.60267385
157Duodenal stenosis (HP:0100867)1.60068012
158Small intestinal stenosis (HP:0012848)1.60068012
159* Abnormality of the nasal septum (HP:0000419)1.59597887
160* Abnormality of the columella (HP:0009929)1.59080001
161Aplasia cutis congenita (HP:0001057)1.58644337
162Pulmonary artery stenosis (HP:0004415)1.58488982
163Vasculitis (HP:0002633)1.57900640
164Cystic hygroma (HP:0000476)1.56925212
165Small hand (HP:0200055)1.56829768
166* Abnormality of the distal phalanx of the thumb (HP:0009617)1.56697833
167Azoospermia (HP:0000027)1.56693163
168Abnormality of the thoracic spine (HP:0100711)1.56484166
169Chest pain (HP:0100749)1.55780052
170Hypochromic anemia (HP:0001931)1.55158548
171Progressive cerebellar ataxia (HP:0002073)1.53749267
172Elevated erythrocyte sedimentation rate (HP:0003565)1.53716071
173Long palpebral fissure (HP:0000637)1.53098413
174Mesomelia (HP:0003027)1.52764273
175Cutaneous finger syndactyly (HP:0010554)1.51765071
176Mitral regurgitation (HP:0001653)1.51318237
177Panhypogammaglobulinemia (HP:0003139)1.51263458
178Chorioretinal coloboma (HP:0000567)1.51222429
179Aplasia/Hypoplasia of the tibia (HP:0005772)1.51183107
180Myelodysplasia (HP:0002863)1.50864737
181Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.50731366
182Skin pits (HP:0100276)1.50222464
183Keratoconjunctivitis (HP:0001096)1.49953411

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.07295032
2ZAK3.06759964
3AKT32.94876243
4CDK122.90678179
5TRIB32.75395952
6MKNK22.69573502
7NUAK12.61208534
8SGK22.57413426
9SIK32.33533808
10MAP3K102.26025952
11STK38L2.22092694
12MAP4K12.20388164
13MKNK12.16650599
14BRD42.16063121
15SIK12.09890492
16SRPK12.07854638
17MARK21.99371727
18TXK1.98009640
19PLK41.92266336
20RIPK41.90312154
21ERN11.83268599
22LATS11.80422457
23ACVR1B1.75197096
24PLK21.72012707
25SIK21.70308732
26BLK1.68941799
27ICK1.68514692
28SMG11.68197284
29ERBB31.67932141
30CDC71.65751645
31SGK31.64791831
32MAP2K31.63803428
33FGFR41.60737238
34EEF2K1.58732670
35BMPR1B1.55919758
36PLK31.52835943
37EPHB11.50638972
38STK241.48448396
39CDK31.47984238
40TAOK11.47243805
41RIPK11.43740409
42BMPR21.43688179
43VRK11.41588455
44YES11.41428976
45PRPF4B1.40773719
46NEK61.39231917
47MAPK131.39184449
48CDK81.37716846
49MAP3K71.34356724
50SGK2231.33656395
51SGK4941.33656395
52WNK11.31174995
53MTOR1.26488439
54EPHA31.25695114
55MAP3K141.24604658
56MAP2K71.22098705
57EIF2AK21.21726215
58ZAP701.21403218
59HIPK21.21174321
60MAP3K131.18715206
61BRSK21.18433665
62TYK21.18132978
63CSK1.17986776
64TYRO31.13369602
65STK31.12739497
66FES1.05365900
67IRAK31.04673724
68NLK1.03074037
69JAK10.99869027
70BTK0.99418145
71GRK60.99261812
72HCK0.97233515
73BCR0.97091588
74ATR0.96524834
75MAP3K30.96285059
76IRAK40.96217986
77ATM0.94850128
78FRK0.93392433
79CHEK20.92928973
80TTN0.91064603
81FGFR30.90835622
82PDGFRB0.89378680
83ADRBK20.85654552
84* CHUK0.85625187
85TRPM70.84667761
86PIM10.84544190
87MAP3K10.83116542
88RPS6KL10.82902032
89CAMKK10.78739594
90MAPK120.78046547
91STK380.77207074
92MAP3K60.76979489
93RPS6KA20.75774173
94STK110.74498694
95KSR20.74464640
96IKBKE0.74202212
97STK40.74083276
98CCNB10.73028448
99PRKCH0.71361619
100RET0.70832943
101CAMK1G0.70772853
102MELK0.70014649
103CHEK10.68886985
104DYRK1A0.66637130
105SGK10.66315299
106JAK30.66275089
107TEC0.66146402
108PTK60.65664127
109DMPK0.65407425
110PKN20.64484225
111SYK0.64219118
112CDK40.64175788
113RPS6KB10.63902100
114TSSK60.63638512
115JAK20.63449297
116FGFR20.62636470
117MAP3K20.62623647
118IRAK20.62610626
119CAMK1D0.61960070
120CLK10.61863585
121PDK10.60953159
122CDK90.60906454
123EPHA40.60692015
124MAPK70.60230054
125PLK10.59242192
126DYRK1B0.58599118
127PIK3CA0.58222463
128IKBKB0.58083120
129ITK0.57534749
130TNIK0.56768689
131PDGFRA0.56406834
132TAOK30.56088287
133CDK70.55752145
134CDK10.55736797
135PDPK10.54388379
136LCK0.54116412
137IRAK10.53398075
138INSRR0.51838566
139MAPK140.51820817
140MAP3K40.51683466
141* CDK20.50474298
142FGR0.50368568
143MAPK110.49983743
144PIK3CG0.47946903
145GSK3B0.46520598
146MAPK80.45569425
147TTK0.45433341
148* CAMK40.45052851
149PRKD20.44340179
150CAMK10.44220878
151MAP3K90.43615326
152PRKCE0.43127624
153CSF1R0.42751491
154* AKT10.41337963
155ERBB40.41262458
156CDC42BPA0.41174920
157PRKD30.40538503
158NEK90.39919004
159AURKB0.37820357
160RPS6KA50.32507288
161TNK20.32255535
162MARK30.31131946
163MAPK100.30247900
164MAPK10.28368413
165RPS6KA60.27970711
166RPS6KC10.27650097

Predicted pathways (KEGG)

RankGene SetZ-score
1Fanconi anemia pathway_Homo sapiens_hsa034602.43879950
2Basal transcription factors_Homo sapiens_hsa030222.33720390
3B cell receptor signaling pathway_Homo sapiens_hsa046622.00521948
4Homologous recombination_Homo sapiens_hsa034401.98122371
5RNA degradation_Homo sapiens_hsa030181.89115839
6* Cell cycle_Homo sapiens_hsa041101.88439124
7Osteoclast differentiation_Homo sapiens_hsa043801.86019480
8Non-small cell lung cancer_Homo sapiens_hsa052231.80738219
9Chronic myeloid leukemia_Homo sapiens_hsa052201.79263599
10Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.72784430
11Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.71245263
12Non-homologous end-joining_Homo sapiens_hsa034501.68688272
13RNA polymerase_Homo sapiens_hsa030201.68364820
14Dorso-ventral axis formation_Homo sapiens_hsa043201.54282664
15Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.51981281
16* Renal cell carcinoma_Homo sapiens_hsa052111.44615131
17Neurotrophin signaling pathway_Homo sapiens_hsa047221.39302205
18Spliceosome_Homo sapiens_hsa030401.37274161
19VEGF signaling pathway_Homo sapiens_hsa043701.37186332
20Base excision repair_Homo sapiens_hsa034101.35154552
21mRNA surveillance pathway_Homo sapiens_hsa030151.33508596
22Mismatch repair_Homo sapiens_hsa034301.32819297
23AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.31560815
24Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.31457177
25Allograft rejection_Homo sapiens_hsa053301.30151256
26mTOR signaling pathway_Homo sapiens_hsa041501.27862270
27Transcriptional misregulation in cancer_Homo sapiens_hsa052021.26850436
28Phospholipase D signaling pathway_Homo sapiens_hsa040721.24084304
29Autoimmune thyroid disease_Homo sapiens_hsa053201.23787450
30NF-kappa B signaling pathway_Homo sapiens_hsa040641.23749309
31* Herpes simplex infection_Homo sapiens_hsa051681.23507241
32Inositol phosphate metabolism_Homo sapiens_hsa005621.21779748
33Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19039989
34Nicotine addiction_Homo sapiens_hsa050331.17268999
35Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16678143
36RNA transport_Homo sapiens_hsa030131.14871108
37Hematopoietic cell lineage_Homo sapiens_hsa046401.14434985
38Basal cell carcinoma_Homo sapiens_hsa052171.14264527
39Phototransduction_Homo sapiens_hsa047441.13467154
40p53 signaling pathway_Homo sapiens_hsa041151.13420391
41Longevity regulating pathway - mammal_Homo sapiens_hsa042111.12707149
42Glioma_Homo sapiens_hsa052141.12481574
43Intestinal immune network for IgA production_Homo sapiens_hsa046721.11254925
44* TGF-beta signaling pathway_Homo sapiens_hsa043501.10630072
45GnRH signaling pathway_Homo sapiens_hsa049121.10562328
46* MicroRNAs in cancer_Homo sapiens_hsa052061.08702168
47Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.07549431
48Graft-versus-host disease_Homo sapiens_hsa053321.07409416
49Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.06544091
50Toxoplasmosis_Homo sapiens_hsa051451.05614074
51Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.05236337
52Circadian rhythm_Homo sapiens_hsa047101.04896724
53Primary immunodeficiency_Homo sapiens_hsa053401.04889464
54Hepatitis C_Homo sapiens_hsa051601.04437224
55Platelet activation_Homo sapiens_hsa046111.04168733
56Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03013692
57Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.02871909
58Type II diabetes mellitus_Homo sapiens_hsa049301.02049012
59Measles_Homo sapiens_hsa051621.01133319
60Estrogen signaling pathway_Homo sapiens_hsa049151.01048314
61Nucleotide excision repair_Homo sapiens_hsa034201.00033689
62Leukocyte transendothelial migration_Homo sapiens_hsa046700.98662013
63* Adherens junction_Homo sapiens_hsa045200.97549942
64Insulin resistance_Homo sapiens_hsa049310.96093799
65Malaria_Homo sapiens_hsa051440.96075744
66* Tuberculosis_Homo sapiens_hsa051520.95736011
67* Prostate cancer_Homo sapiens_hsa052150.95311402
68Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.94900197
69NOD-like receptor signaling pathway_Homo sapiens_hsa046210.94533827
70Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.92364427
71Insulin signaling pathway_Homo sapiens_hsa049100.91492417
72Asthma_Homo sapiens_hsa053100.91038238
73Hedgehog signaling pathway_Homo sapiens_hsa043400.89818861
74* Wnt signaling pathway_Homo sapiens_hsa043100.88666671
75Colorectal cancer_Homo sapiens_hsa052100.87438991
76* Long-term potentiation_Homo sapiens_hsa047200.86009339
77* Epstein-Barr virus infection_Homo sapiens_hsa051690.85798956
78Hippo signaling pathway_Homo sapiens_hsa043900.85461144
79Staphylococcus aureus infection_Homo sapiens_hsa051500.84395741
80* HTLV-I infection_Homo sapiens_hsa051660.83612125
81Amoebiasis_Homo sapiens_hsa051460.83290925
82Melanoma_Homo sapiens_hsa052180.81379217
83DNA replication_Homo sapiens_hsa030300.80527645
84Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.80141535
85Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79898344
86Sphingolipid signaling pathway_Homo sapiens_hsa040710.79112615
87* Jak-STAT signaling pathway_Homo sapiens_hsa046300.79048658
88* FoxO signaling pathway_Homo sapiens_hsa040680.78488992
89Thyroid cancer_Homo sapiens_hsa052160.77911183
90Proteoglycans in cancer_Homo sapiens_hsa052050.77896859
91* Influenza A_Homo sapiens_hsa051640.76938030
92Endometrial cancer_Homo sapiens_hsa052130.75300081
93Apoptosis_Homo sapiens_hsa042100.75105183
94Rap1 signaling pathway_Homo sapiens_hsa040150.75095409
95Axon guidance_Homo sapiens_hsa043600.74997945
96Focal adhesion_Homo sapiens_hsa045100.74224579
97Lysine degradation_Homo sapiens_hsa003100.73587122
98Taste transduction_Homo sapiens_hsa047420.73493091
99Cholinergic synapse_Homo sapiens_hsa047250.73434479
100Serotonergic synapse_Homo sapiens_hsa047260.73405778
101* Pathways in cancer_Homo sapiens_hsa052000.73118636
102Carbohydrate digestion and absorption_Homo sapiens_hsa049730.71816424
103Adipocytokine signaling pathway_Homo sapiens_hsa049200.71753492
104* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.71366908
105Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.70553459
106T cell receptor signaling pathway_Homo sapiens_hsa046600.69595020
107Bladder cancer_Homo sapiens_hsa052190.69310314
108Rheumatoid arthritis_Homo sapiens_hsa053230.69108096
109TNF signaling pathway_Homo sapiens_hsa046680.69073465
110MAPK signaling pathway_Homo sapiens_hsa040100.68753977
111Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68091612
112Amphetamine addiction_Homo sapiens_hsa050310.67959944
113* Hepatitis B_Homo sapiens_hsa051610.67516943
114Leishmaniasis_Homo sapiens_hsa051400.66301854
115RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.66179225
116AMPK signaling pathway_Homo sapiens_hsa041520.66081562
117Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.65689541
118Endocytosis_Homo sapiens_hsa041440.64935413
119Oocyte meiosis_Homo sapiens_hsa041140.64589612
120Type I diabetes mellitus_Homo sapiens_hsa049400.64188847
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.63184382
122Regulation of actin cytoskeleton_Homo sapiens_hsa048100.62922272
123Morphine addiction_Homo sapiens_hsa050320.62818747
124Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.62371598
125Ovarian steroidogenesis_Homo sapiens_hsa049130.62057673
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.62002267
127Oxytocin signaling pathway_Homo sapiens_hsa049210.60973158
128Phosphatidylinositol signaling system_Homo sapiens_hsa040700.60702343
129Purine metabolism_Homo sapiens_hsa002300.60397248
130Viral myocarditis_Homo sapiens_hsa054160.59798559
131Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.59730782
132Pancreatic cancer_Homo sapiens_hsa052120.59024733
133Olfactory transduction_Homo sapiens_hsa047400.57600979
134Circadian entrainment_Homo sapiens_hsa047130.57551451
135Chemokine signaling pathway_Homo sapiens_hsa040620.56545007
136ErbB signaling pathway_Homo sapiens_hsa040120.55710417
137* HIF-1 signaling pathway_Homo sapiens_hsa040660.55647994
138* cAMP signaling pathway_Homo sapiens_hsa040240.55566409
139* Notch signaling pathway_Homo sapiens_hsa043300.55278270
140cGMP-PKG signaling pathway_Homo sapiens_hsa040220.55205124
141* Viral carcinogenesis_Homo sapiens_hsa052030.55040762
142Long-term depression_Homo sapiens_hsa047300.53479605
143Prolactin signaling pathway_Homo sapiens_hsa049170.52631035
144Small cell lung cancer_Homo sapiens_hsa052220.52541370
145Acute myeloid leukemia_Homo sapiens_hsa052210.52335170
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.52100649
147Dilated cardiomyopathy_Homo sapiens_hsa054140.51773826
148African trypanosomiasis_Homo sapiens_hsa051430.51664844
149Ras signaling pathway_Homo sapiens_hsa040140.51074183
150Choline metabolism in cancer_Homo sapiens_hsa052310.50802671
151Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50520841
152Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.49569938
153Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49492701

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