CREG1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The adenovirus E1A protein both activates and represses gene expression to promote cellular proliferation and inhibit differentiation. The protein encoded by this gene antagonizes transcriptional activation and cellular transformation by E1A. This protein shares limited sequence similarity with E1A and binds both the general transcription factor TBP and the tumor suppressor pRb in vitro. This gene may contribute to the transcriptional control of cell growth and differentiation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.42393580
2L-phenylalanine catabolic process (GO:0006559)5.42393580
3triglyceride-rich lipoprotein particle remodeling (GO:0034370)5.29961000
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.26218633
5L-phenylalanine metabolic process (GO:0006558)5.26218633
6response to peptidoglycan (GO:0032494)4.92464897
7aromatic amino acid family catabolic process (GO:0009074)4.92359445
8neutrophil activation involved in immune response (GO:0002283)4.69127860
9glycosphingolipid catabolic process (GO:0046479)4.63285517
10peptidyl-glutamic acid carboxylation (GO:0017187)4.62135463
11protein carboxylation (GO:0018214)4.62135463
12cysteine metabolic process (GO:0006534)4.61075646
13cellular response to thyroid hormone stimulus (GO:0097067)4.61066555
14indole-containing compound catabolic process (GO:0042436)4.48740372
15indolalkylamine catabolic process (GO:0046218)4.48740372
16tryptophan catabolic process (GO:0006569)4.48740372
17bile acid biosynthetic process (GO:0006699)4.46603724
18alpha-linolenic acid metabolic process (GO:0036109)4.39904317
19oligosaccharide catabolic process (GO:0009313)4.38821374
20high-density lipoprotein particle remodeling (GO:0034375)4.35543206
21kynurenine metabolic process (GO:0070189)4.35527332
22negative regulation of interleukin-12 production (GO:0032695)4.35359381
23urea metabolic process (GO:0019627)4.33504881
24urea cycle (GO:0000050)4.33504881
25tryptophan metabolic process (GO:0006568)4.32762209
26glyoxylate metabolic process (GO:0046487)4.25862943
27fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.25224792
28complement activation, alternative pathway (GO:0006957)4.24830067
29sulfur amino acid catabolic process (GO:0000098)4.18567380
30glycolipid catabolic process (GO:0019377)4.17937837
31regulation of protein activation cascade (GO:2000257)4.13143289
32plasma lipoprotein particle clearance (GO:0034381)4.05351280
33plasma lipoprotein particle remodeling (GO:0034369)4.04230805
34protein-lipid complex remodeling (GO:0034368)4.04230805
35macromolecular complex remodeling (GO:0034367)4.04230805
36nitrogen cycle metabolic process (GO:0071941)4.02487573
37negative regulation of fibrinolysis (GO:0051918)4.00482435
38regulation of cholesterol esterification (GO:0010872)3.98165361
39phospholipid efflux (GO:0033700)3.94113763
40negative regulation of erythrocyte differentiation (GO:0045647)3.92096891
41regulation of complement activation (GO:0030449)3.91207268
42reverse cholesterol transport (GO:0043691)3.90973512
43response to thyroid hormone (GO:0097066)3.85868614
44lipopolysaccharide-mediated signaling pathway (GO:0031663)3.84827882
45bile acid metabolic process (GO:0008206)3.83164893
46regulation of triglyceride catabolic process (GO:0010896)3.83137576
47amino-acid betaine metabolic process (GO:0006577)3.82247020
48regulation of fibrinolysis (GO:0051917)3.81875647
49aldehyde catabolic process (GO:0046185)3.77999160
50regulation of mononuclear cell migration (GO:0071675)3.76612000
51lysine metabolic process (GO:0006553)3.73940271
52lysine catabolic process (GO:0006554)3.73940271
53plasma lipoprotein particle assembly (GO:0034377)3.73299486
54ceramide catabolic process (GO:0046514)3.67298741
55low-density lipoprotein particle remodeling (GO:0034374)3.66407553
56cholesterol efflux (GO:0033344)3.64729414
57homocysteine metabolic process (GO:0050667)3.60955510
58aromatic amino acid family metabolic process (GO:0009072)3.56064504
59cofactor catabolic process (GO:0051187)3.53836317
60macrophage activation involved in immune response (GO:0002281)3.53315594
61very-low-density lipoprotein particle assembly (GO:0034379)3.51835348
62T-helper 1 type immune response (GO:0042088)3.51224554
63serine family amino acid catabolic process (GO:0009071)3.48431946
64blood coagulation, intrinsic pathway (GO:0007597)3.47683335
65immunoglobulin mediated immune response (GO:0016064)3.46253669
66plasma lipoprotein particle organization (GO:0071827)3.45243044
67regulation of vitamin D biosynthetic process (GO:0060556)3.43797612
68triglyceride homeostasis (GO:0070328)3.43683908
69acylglycerol homeostasis (GO:0055090)3.43683908
70protein-lipid complex assembly (GO:0065005)3.41506931
71tyrosine metabolic process (GO:0006570)3.41467414
72positive regulation of gamma-delta T cell activation (GO:0046645)3.40511162
73amino sugar catabolic process (GO:0046348)3.39644638
74negative regulation of sterol transport (GO:0032372)3.36934927
75negative regulation of cholesterol transport (GO:0032375)3.36934927
76bile acid and bile salt transport (GO:0015721)3.33573599
77ethanol oxidation (GO:0006069)3.33014764
78fibrinolysis (GO:0042730)3.31792726
79protein-lipid complex subunit organization (GO:0071825)3.28592944
80phospholipid homeostasis (GO:0055091)3.27698182
81alpha-amino acid catabolic process (GO:1901606)3.27151061
82regulation of mast cell degranulation (GO:0043304)3.25456595
83imidazole-containing compound metabolic process (GO:0052803)3.23637251
84antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.20867539
85indolalkylamine metabolic process (GO:0006586)3.20013650
86disruption of cells of other organism involved in symbiotic interaction (GO:0051818)3.19684303
87killing of cells in other organism involved in symbiotic interaction (GO:0051883)3.19684303
88detection of molecule of bacterial origin (GO:0032490)3.18766195
89cellular glucuronidation (GO:0052695)3.18543426
90glycine metabolic process (GO:0006544)3.17969201
91positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.17314382
92protein activation cascade (GO:0072376)3.16920634
93amine catabolic process (GO:0009310)3.15929649
94cellular biogenic amine catabolic process (GO:0042402)3.15929649
95response to nitrosative stress (GO:0051409)3.14979515
96regulation of cholesterol storage (GO:0010885)3.14364185
97benzene-containing compound metabolic process (GO:0042537)3.13173490
98positive regulation of cellular amide metabolic process (GO:0034250)3.11538575
99carnitine metabolic process (GO:0009437)3.10571424
100valine metabolic process (GO:0006573)3.10179904
101positive regulation of triglyceride lipase activity (GO:0061365)3.09328400
102positive regulation of lipoprotein lipase activity (GO:0051006)3.09328400
103positive regulation of heterotypic cell-cell adhesion (GO:0034116)3.08748618
104serine family amino acid metabolic process (GO:0009069)3.08229380
105positive regulation by symbiont of host defense response (GO:0052509)3.08088102
106modulation by symbiont of host defense response (GO:0052031)3.08088102
107modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.08088102
108modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.08088102
109positive regulation by organism of defense response of other organism involved in symbiotic interact3.08088102
110modulation by symbiont of host immune response (GO:0052553)3.08088102
111positive regulation of leukocyte degranulation (GO:0043302)3.05698501
112cellular modified amino acid catabolic process (GO:0042219)3.05274236
113regulation of macrophage chemotaxis (GO:0010758)3.05182989
114cholesterol homeostasis (GO:0042632)3.04364826
115negative regulation of nitric oxide biosynthetic process (GO:0045019)3.04155639
116positive regulation of chemokine biosynthetic process (GO:0045080)3.03612700
117nicotinamide nucleotide biosynthetic process (GO:0019359)3.02577139
118pyridine nucleotide biosynthetic process (GO:0019363)3.02577139
119regulation of T-helper 1 cell differentiation (GO:0045625)3.02113277
120cellular amino acid catabolic process (GO:0009063)3.01996168
121cellular ketone body metabolic process (GO:0046950)3.01890304
122protoporphyrinogen IX metabolic process (GO:0046501)3.01840264
123acute-phase response (GO:0006953)3.01406441
124regulation of podosome assembly (GO:0071801)3.01385258
125complement activation (GO:0006956)3.00720190
126regulation of vitamin metabolic process (GO:0030656)3.00591245
127positive regulation of lipid catabolic process (GO:0050996)3.00214485
128sterol homeostasis (GO:0055092)3.00148059
129pinocytosis (GO:0006907)2.99739460
130detection of other organism (GO:0098543)2.99513227
131coenzyme catabolic process (GO:0009109)2.99058183
132complement activation, classical pathway (GO:0006958)2.99007581
133granulocyte activation (GO:0036230)2.98764934
134membrane lipid catabolic process (GO:0046466)2.98430358
135positive regulation of monocyte chemotaxis (GO:0090026)2.98162537
136NAD biosynthetic process (GO:0009435)2.98142891
137glutamate metabolic process (GO:0006536)2.97443656
138low-density lipoprotein particle clearance (GO:0034383)2.97413322
139lipoprotein metabolic process (GO:0042157)2.96845712
140glucuronate metabolic process (GO:0019585)2.96655441
141regulation of leukocyte degranulation (GO:0043300)2.95773203
142regulation of mast cell activation involved in immune response (GO:0033006)2.95331742
143negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.94337832
144positive regulation of mast cell activation involved in immune response (GO:0033008)2.90658700
145positive regulation of mast cell degranulation (GO:0043306)2.90658700
146response to muramyl dipeptide (GO:0032495)2.88993350
147sphingolipid catabolic process (GO:0030149)2.88326166
148N-acetylneuraminate metabolic process (GO:0006054)2.87912503
149detection of external biotic stimulus (GO:0098581)2.87388608
150positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.82208353
151negative regulation of cytokine production involved in immune response (GO:0002719)2.81924961
152germinal center formation (GO:0002467)2.81196266
153adhesion of symbiont to host cell (GO:0044650)2.79267221
154virion attachment to host cell (GO:0019062)2.79267221
155regulation of membrane protein ectodomain proteolysis (GO:0051043)2.78035313
156regulation of myeloid leukocyte mediated immunity (GO:0002886)2.77836082
157positive regulation of mast cell activation (GO:0033005)2.75054330
158regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.74715249
159detection of bacterium (GO:0016045)2.73888246
160regulation of chemokine biosynthetic process (GO:0045073)2.73560443
161myeloid dendritic cell differentiation (GO:0043011)2.73317232
162negative regulation of myeloid cell apoptotic process (GO:0033033)2.73094206
163interferon-gamma-mediated signaling pathway (GO:0060333)2.71154164
164regulation of cytokine secretion involved in immune response (GO:0002739)2.68864274
165negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.68655534
166adhesion of symbiont to host (GO:0044406)2.68555622
167positive regulation of myeloid leukocyte mediated immunity (GO:0002888)2.68329499
168positive regulation of cholesterol efflux (GO:0010875)2.68319599
169cellular response to arsenic-containing substance (GO:0071243)2.66720342
170regulation of interferon-alpha production (GO:0032647)2.66417759
171NIK/NF-kappaB signaling (GO:0038061)2.66195942
172fat-soluble vitamin biosynthetic process (GO:0042362)2.65528285
173negative regulation of lipid storage (GO:0010888)2.64784282
174myeloid cell activation involved in immune response (GO:0002275)2.63841122
175negative regulation of interleukin-17 production (GO:0032700)2.62852771
176cellular response to lipopolysaccharide (GO:0071222)2.61764090
177regulation of superoxide anion generation (GO:0032928)2.58859429
178positive regulation of antigen processing and presentation (GO:0002579)2.57780642
179barbed-end actin filament capping (GO:0051016)2.56021498
180positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.55217106
181macrophage activation (GO:0042116)2.55093850
182cellular response to molecule of bacterial origin (GO:0071219)2.53996730
183positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.53840681
184neutrophil activation (GO:0042119)2.53774864
185regulation of T-helper 2 cell differentiation (GO:0045628)2.52266904
186positive regulation of type 2 immune response (GO:0002830)2.52153856
187peptide catabolic process (GO:0043171)2.51933637
188response to protozoan (GO:0001562)2.51911088
189positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.50246234
190myeloid dendritic cell activation (GO:0001773)2.50233047
191macrophage differentiation (GO:0030225)2.49999282
192monocyte chemotaxis (GO:0002548)2.49792655
193B cell mediated immunity (GO:0019724)2.49369188
194regulation of interferon-beta biosynthetic process (GO:0045357)2.49161313
195regulation of monocyte chemotaxis (GO:0090025)2.48966246
196detection of biotic stimulus (GO:0009595)2.48559312
197positive regulation of interleukin-6 production (GO:0032755)2.46987461
198mature B cell differentiation involved in immune response (GO:0002313)2.46739450

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse8.15458996
2* RXR_22158963_ChIP-Seq_LIVER_Mouse5.71510167
3* PPARA_22158963_ChIP-Seq_LIVER_Mouse5.02874610
4EGR1_23403033_ChIP-Seq_LIVER_Mouse4.88409215
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.34957536
6PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.99109564
7IRF8_22096565_ChIP-ChIP_GC-B_Human3.85107427
8CEBPA_23403033_ChIP-Seq_LIVER_Mouse3.79070484
9FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.57787969
10GATA1_22025678_ChIP-Seq_K562_Human3.17995387
11CEBPB_23403033_ChIP-Seq_LIVER_Mouse3.04154673
12IRF8_21731497_ChIP-ChIP_J774_Mouse2.86237329
13BP1_19119308_ChIP-ChIP_Hs578T_Human2.33962524
14* SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.23191089
15NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.21941949
16IRF8_27001747_Chip-Seq_BMDM_Mouse2.18685824
17* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.18216386
18* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse2.10082788
19IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09796093
20MYB_21317192_ChIP-Seq_ERMYB_Mouse2.06304201
21* MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.02288176
22TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.94493898
23IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93198969
24SCL_19346495_ChIP-Seq_HPC-7_Human1.92565737
25NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.91014566
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.78535141
27STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.77171909
28VDR_24787735_ChIP-Seq_THP-1_Human1.72443433
29RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.71168998
30HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.64196904
31* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.63217503
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.62094688
33ELK3_25401928_ChIP-Seq_HUVEC_Human1.61987180
34* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.60792394
35THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.48649652
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.47727816
37TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.44848454
38GATA1_19941827_ChIP-Seq_MEL_Mouse1.39898913
39KDM2B_26808549_Chip-Seq_SUP-B15_Human1.36977488
40* GATA1_22383799_ChIP-Seq_G1ME_Mouse1.36200699
41* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.34658872
42* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.32084342
43KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.30471174
44GATA1_19941826_ChIP-Seq_K562_Human1.29589973
45TCF7_22412390_ChIP-Seq_EML_Mouse1.29573630
46ESR2_21235772_ChIP-Seq_MCF-7_Human1.28409564
47SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.27857791
48NCOR1_26117541_ChIP-Seq_K562_Human1.26733950
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.26655171
50* GATA2_22383799_ChIP-Seq_G1ME_Mouse1.24992527
51SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.24357795
52MYC_22102868_ChIP-Seq_BL_Human1.23191503
53* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21171817
54CLOCK_20551151_ChIP-Seq_293T_Human1.20052629
55* GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.18993550
56* LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.18370270
57SPI1_23547873_ChIP-Seq_NB4_Human1.17406884
58STAT4_19710469_ChIP-ChIP_TH1__Mouse1.15499934
59* LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.15083276
60STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13052017
61CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.12772490
62* KDM2B_26808549_Chip-Seq_DND41_Human1.11390535
63NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.10418477
64CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.09656739
65RUNX1_22412390_ChIP-Seq_EML_Mouse1.08745799
66SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08671388
67CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.05792634
68ELF1_17652178_ChIP-ChIP_JURKAT_Human1.05482451
69* RACK7_27058665_Chip-Seq_MCF-7_Human1.04653757
70PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01560550
71FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.00428635
72MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00249071
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.00102721
74VDR_21846776_ChIP-Seq_THP-1_Human0.99272769
75SRY_22984422_ChIP-ChIP_TESTIS_Rat0.99223394
76* KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98994971
77CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.98262693
78* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.97787663
79PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.97486261
80CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.97427876
81GATA2_19941826_ChIP-Seq_K562_Human0.96869268
82RARG_19884340_ChIP-ChIP_MEFs_Mouse0.96555309
83VDR_24763502_ChIP-Seq_THP-1_Human0.95761630
84* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.94399686
85* PU_27001747_Chip-Seq_BMDM_Mouse0.93262570
86TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.92989460
87NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.92885907
88MAF_26560356_Chip-Seq_TH1_Human0.91898441
89RUNX_20019798_ChIP-Seq_JUKART_Human0.91783177
90* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89510266
91MAF_26560356_Chip-Seq_TH2_Human0.88994731
92GATA4_25053715_ChIP-Seq_YYC3_Human0.88919588
93SOX2_27498859_Chip-Seq_STOMACH_Mouse0.87168426
94HNF4A_19822575_ChIP-Seq_HepG2_Human0.86906584
95E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.86516801
96FOXA2_19822575_ChIP-Seq_HepG2_Human0.86342876
97PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85082798
98SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.84478940
99PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.83498071
100MYB_26560356_Chip-Seq_TH1_Human0.82978168
101STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.82870244
102RXRA_24833708_ChIP-Seq_LIVER_Mouse0.80106976
103* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.79457010
104EGR1_19374776_ChIP-ChIP_THP-1_Human0.79194836
105MYB_26560356_Chip-Seq_TH2_Human0.78772783
106GATA2_21666600_ChIP-Seq_HMVEC_Human0.78537843
107PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.78445289
108TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.78318643
109STAT3_1855785_ChIP-Seq_MESCs_Mouse0.77372635
110ZNF263_19887448_ChIP-Seq_K562_Human0.76667365
111SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.76599454
112SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.75804781
113TFEB_21752829_ChIP-Seq_HELA_Human0.75141533
114STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.73625446
115HTT_18923047_ChIP-ChIP_STHdh_Human0.73359338
116LXR_22292898_ChIP-Seq_THP-1_Human0.72099893
117SPI1_23127762_ChIP-Seq_K562_Human0.71839012
118SALL4_18804426_ChIP-ChIP_XEN_Mouse0.71469545
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.70268572
120UTX_26944678_Chip-Seq_JUKART_Human0.68474603
121* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.68073500
122EGR1_19032775_ChIP-ChIP_M12_Human0.67902307
123TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67784200

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system5.87299561
2MP0005360_urolithiasis5.06006575
3MP0005365_abnormal_bile_salt4.44874891
4MP0005085_abnormal_gallbladder_physiolo4.40097957
5MP0008875_abnormal_xenobiotic_pharmacok3.67444328
6MP0009840_abnormal_foam_cell3.57427090
7MP0003806_abnormal_nucleotide_metabolis3.08917452
8MP0005083_abnormal_biliary_tract2.93774492
9MP0003191_abnormal_cellular_cholesterol2.89217769
10MP0010329_abnormal_lipoprotein_level2.84706834
11MP0003656_abnormal_erythrocyte_physiolo2.78960771
12MP0003252_abnormal_bile_duct2.77652151
13MP0005058_abnormal_lysosome_morphology2.40191635
14MP0003195_calcinosis2.39865772
15MP0003436_decreased_susceptibility_to2.04250464
16MP0001666_abnormal_nutrient_absorption2.02686789
17MP0009278_abnormal_bone_marrow2.01929371
18MP0000609_abnormal_liver_physiology2.01051382
19MP0005332_abnormal_amino_acid1.98263457
20MP0003186_abnormal_redox_activity1.89731740
21MP0002138_abnormal_hepatobiliary_system1.87249806
22MP0001835_abnormal_antigen_presentation1.85894413
23MP0008004_abnormal_stomach_pH1.83689010
24MP0005319_abnormal_enzyme/_coenzyme1.78945529
25MP0006082_CNS_inflammation1.74265604
26MP0003453_abnormal_keratinocyte_physiol1.73293591
27MP0005464_abnormal_platelet_physiology1.72005634
28MP0002118_abnormal_lipid_homeostasis1.69900527
29MP0003724_increased_susceptibility_to1.66687052
30MP0002998_abnormal_bone_remodeling1.61290210
31MP0002419_abnormal_innate_immunity1.57064222
32MP0009764_decreased_sensitivity_to1.55923876
33MP0008469_abnormal_protein_level1.53677531
34MP0003172_abnormal_lysosome_physiology1.50776381
35MP0004019_abnormal_vitamin_homeostasis1.50453016
36MP0009785_altered_susceptibility_to1.50273008
37MP0003303_peritoneal_inflammation1.45145652
38MP0005584_abnormal_enzyme/coenzyme_acti1.44997482
39MP0000858_altered_metastatic_potential1.41312680
40MP0004147_increased_porphyrin_level1.41300031
41MP0005025_abnormal_response_to1.39019108
42MP0009643_abnormal_urine_homeostasis1.37495037
43MP0001764_abnormal_homeostasis1.37124984
44MP0003868_abnormal_feces_composition1.32533278
45MP0003448_altered_tumor_morphology1.29549026
46MP0000604_amyloidosis1.28773133
47MP0000598_abnormal_liver_morphology1.27638242
48MP0003828_pulmonary_edema1.26931304
49MP0009763_increased_sensitivity_to1.24078918
50MP0001853_heart_inflammation1.21309585
51MP0003011_delayed_dark_adaptation1.21152021
52MP0008260_abnormal_autophagy1.19121507
53MP0000685_abnormal_immune_system1.16806364
54MP0003300_gastrointestinal_ulcer1.14682305
55MP0005000_abnormal_immune_tolerance1.14030094
56MP0005310_abnormal_salivary_gland1.13612329
57MP0001845_abnormal_inflammatory_respons1.13016663
58MP0005636_abnormal_mineral_homeostasis1.09559739
59MP0002148_abnormal_hypersensitivity_rea1.05977686
60MP0003329_amyloid_beta_deposits1.05761939
61MP0005165_increased_susceptibility_to1.05324618
62MP0005397_hematopoietic_system_phenotyp1.01563821
63MP0001545_abnormal_hematopoietic_system1.01563821
64MP0006054_spinal_hemorrhage1.00981829
65MP0006036_abnormal_mitochondrial_physio0.99440968
66MP0002452_abnormal_antigen_presenting0.99169968
67MP0001533_abnormal_skeleton_physiology0.98404244
68MP0003075_altered_response_to0.97979259
69MP0005387_immune_system_phenotype0.97822715
70MP0001790_abnormal_immune_system0.97822715
71MP0004130_abnormal_muscle_cell0.97594490
72MP0010234_abnormal_vibrissa_follicle0.97392754
73MP0002723_abnormal_immune_serum0.96078120
74MP0000343_altered_response_to0.96067337
75MP0009697_abnormal_copulation0.95790394
76MP0004947_skin_inflammation0.94412240
77MP0001851_eye_inflammation0.94030088
78MP0001800_abnormal_humoral_immune0.93732589
79MP0005451_abnormal_body_composition0.92744594
80MP0003183_abnormal_peptide_metabolism0.92002879
81MP0002796_impaired_skin_barrier0.91835039
82MP0002254_reproductive_system_inflammat0.90189694
83MP0009642_abnormal_blood_homeostasis0.89970141
84MP0003705_abnormal_hypodermis_morpholog0.89706058
85MP0005671_abnormal_response_to0.89110774
86MP0000920_abnormal_myelination0.88968402
87MP0003690_abnormal_glial_cell0.88600182
88MP0002398_abnormal_bone_marrow0.87653978
89MP0004782_abnormal_surfactant_physiolog0.86052704
90MP0005670_abnormal_white_adipose0.82630557
91MP0005666_abnormal_adipose_tissue0.82270656
92MP0002332_abnormal_exercise_endurance0.81873059
93MP0004883_abnormal_blood_vessel0.80986682
94MP0005166_decreased_susceptibility_to0.79348823
95MP0001819_abnormal_immune_cell0.77449009
96MP0002420_abnormal_adaptive_immunity0.76803246
97MP0004808_abnormal_hematopoietic_stem0.76236757
98MP0009765_abnormal_xenobiotic_induced0.75950268
99MP0001756_abnormal_urination0.75794311
100MP0002166_altered_tumor_susceptibility0.75616824
101MP0002078_abnormal_glucose_homeostasis0.75503657
102MP0003795_abnormal_bone_structure0.75420467
103MP0002971_abnormal_brown_adipose0.75416154
104MP0005334_abnormal_fat_pad0.74825564
105MP0010155_abnormal_intestine_physiology0.74703529
106MP0005220_abnormal_exocrine_pancreas0.74507942
107MP0002722_abnormal_immune_system0.74331713
108MP0000689_abnormal_spleen_morphology0.73903891
109MP0005390_skeleton_phenotype0.73463608
110MP0005376_homeostasis/metabolism_phenot0.72816380
111MP0002136_abnormal_kidney_physiology0.72420714
112MP0005023_abnormal_wound_healing0.72338330
113MP0008874_decreased_physiological_sensi0.71961578
114MP0002405_respiratory_system_inflammati0.71678730
115MP0005647_abnormal_sex_gland0.68268343
116MP0001216_abnormal_epidermal_layer0.67821017
117MP0000465_gastrointestinal_hemorrhage0.67312081
118MP0001542_abnormal_bone_strength0.67004758
119MP0005408_hypopigmentation0.66854490
120MP0004185_abnormal_adipocyte_glucose0.66751689
121MP0004510_myositis0.65484326
122MP0005167_abnormal_blood-brain_barrier0.65396985
123MP0008873_increased_physiological_sensi0.64396855
124MP0003091_abnormal_cell_migration0.63523521
125MP0005164_abnormal_response_to0.63230581
126MP0000716_abnormal_immune_system0.62741194
127MP0010307_abnormal_tumor_latency0.62257066
128MP0000249_abnormal_blood_vessel0.61656561
129MP0002429_abnormal_blood_cell0.61607781
130MP0009333_abnormal_splenocyte_physiolog0.61455538
131MP0005535_abnormal_body_temperature0.60907123
132MP0002877_abnormal_melanocyte_morpholog0.60167885

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of glycolipid metabolism (HP:0010969)7.33162526
2Abnormality of liposaccharide metabolism (HP:0010968)7.33162526
3Abnormality of glycosphingolipid metabolism (HP:0004343)7.33162526
4Abnormality of aromatic amino acid family metabolism (HP:0004338)5.30375217
5Intrahepatic cholestasis (HP:0001406)4.99935764
6Deep venous thrombosis (HP:0002625)4.90954558
7Xanthomatosis (HP:0000991)4.87818798
8Prolonged partial thromboplastin time (HP:0003645)4.70971773
9Abnormality of monocarboxylic acid metabolism (HP:0010996)4.65972582
10Hyperlipoproteinemia (HP:0010980)4.39019094
11Complement deficiency (HP:0004431)4.22313917
12Recurrent gram-negative bacterial infections (HP:0005420)4.21964167
13Joint hemorrhage (HP:0005261)4.14840255
14Hypobetalipoproteinemia (HP:0003563)4.11938848
15Loss of speech (HP:0002371)4.05872888
16Disinhibition (HP:0000734)3.99905711
17Abnormality of the common coagulation pathway (HP:0010990)3.65867237
18Systemic lupus erythematosus (HP:0002725)3.58337155
19Hypoglycemic coma (HP:0001325)3.36571256
20Hypolipoproteinemia (HP:0010981)3.35950638
21Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.32950262
22Vacuolated lymphocytes (HP:0001922)3.32866416
23Abnormality of complement system (HP:0005339)3.31869297
24Hyperammonemia (HP:0001987)3.30922578
25Epidermoid cyst (HP:0200040)3.29705828
26Hypercholesterolemia (HP:0003124)3.26359245
27Abnormality of the intrinsic pathway (HP:0010989)3.22420430
28Mutism (HP:0002300)3.21737190
29Hypoalphalipoproteinemia (HP:0003233)3.17503855
30Hyperbilirubinemia (HP:0002904)3.17049576
31Myocardial infarction (HP:0001658)3.16855859
32Recurrent bacterial skin infections (HP:0005406)3.14867273
33Fat malabsorption (HP:0002630)3.12886929
34Neurofibrillary tangles (HP:0002185)3.10636246
35Ketosis (HP:0001946)3.05282291
36Abnormality of glutamine family amino acid metabolism (HP:0010902)3.02149941
37Increased cerebral lipofuscin (HP:0011813)3.00430556
38Eczematoid dermatitis (HP:0000976)2.98152606
39Poikilocytosis (HP:0004447)2.98132713
40Abnormality of sulfur amino acid metabolism (HP:0004339)2.97281904
41Abnormality of fatty-acid metabolism (HP:0004359)2.89228500
42Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.87984281
43Abnormality of methionine metabolism (HP:0010901)2.86418874
44Acanthocytosis (HP:0001927)2.85771190
45Glomerulonephritis (HP:0000099)2.85431128
46Recurrent abscess formation (HP:0002722)2.79820382
47Abnormality of aspartate family amino acid metabolism (HP:0010899)2.76301293
48Orchitis (HP:0100796)2.75941684
49Mediastinal lymphadenopathy (HP:0100721)2.75291007
50Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.72887485
51Increased neuronal autofluorescent lipopigment (HP:0002074)2.71476386
52Myositis (HP:0100614)2.71258885
53Hyperglycinemia (HP:0002154)2.70426346
54Nuclear cataract (HP:0100018)2.69026716
55Gingival bleeding (HP:0000225)2.67562798
56Abnormality of the heme biosynthetic pathway (HP:0010472)2.64219223
57Axonal loss (HP:0003447)2.60609139
58Mucopolysacchariduria (HP:0008155)2.60114985
59Urinary glycosaminoglycan excretion (HP:0003541)2.60114985
60Nausea (HP:0002018)2.60107141
61Abnormality of iron homeostasis (HP:0011031)2.58010727
62Hepatocellular carcinoma (HP:0001402)2.57286969
63Hepatosplenomegaly (HP:0001433)2.56719700
64Abnormality of pyrimidine metabolism (HP:0004353)2.56671856
65Steatorrhea (HP:0002570)2.55399177
66Spontaneous hematomas (HP:0007420)2.54110996
67Abnormality of macrophages (HP:0004311)2.53651453
68Dysostosis multiplex (HP:0000943)2.53379424
69Conjugated hyperbilirubinemia (HP:0002908)2.52750128
70Hyperglycinuria (HP:0003108)2.50211997
71Chronic obstructive pulmonary disease (HP:0006510)2.49402698
72Obstructive lung disease (HP:0006536)2.49402698
73Menorrhagia (HP:0000132)2.48536879
74Retrobulbar optic neuritis (HP:0100654)2.48130669
75Optic neuritis (HP:0100653)2.48130669
76Abnormality of transition element cation homeostasis (HP:0011030)2.47809286
77Increased serum ferritin (HP:0003281)2.43207974
78Diminished motivation (HP:0000745)2.41930390
79Abnormality of nucleobase metabolism (HP:0010932)2.41543931
80Abnormality of polysaccharide metabolism (HP:0011012)2.41338301
81Abnormality of glycosaminoglycan metabolism (HP:0004371)2.41338301
82Abnormality of mucopolysaccharide metabolism (HP:0011020)2.41338301
83Progressive neurologic deterioration (HP:0002344)2.40690977
84Abnormality of serine family amino acid metabolism (HP:0010894)2.39954728
85Abnormality of glycine metabolism (HP:0010895)2.39954728
86Cholelithiasis (HP:0001081)2.39308853
87Cerebral inclusion bodies (HP:0100314)2.39139050
88Apathy (HP:0000741)2.38895714
89Abnormal gallbladder morphology (HP:0012437)2.35771584
90Abnormality of purine metabolism (HP:0004352)2.33979969
91Generalized aminoaciduria (HP:0002909)2.33162438
92Reticulocytosis (HP:0001923)2.32141367
93Epistaxis (HP:0000421)2.31026821
94Hypochromic microcytic anemia (HP:0004840)2.29228951
95Skin nodule (HP:0200036)2.29105915
96Esophageal varix (HP:0002040)2.28948755
97Ketoacidosis (HP:0001993)2.28638398
98Upper motor neuron abnormality (HP:0002127)2.28400954
99Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.27738238
100Neuronal loss in central nervous system (HP:0002529)2.25641877
101Dicarboxylic aciduria (HP:0003215)2.23453045
102Abnormality of dicarboxylic acid metabolism (HP:0010995)2.23453045
103Polycythemia (HP:0001901)2.18829846
104Asymmetric septal hypertrophy (HP:0001670)2.18554219
105Impaired platelet aggregation (HP:0003540)2.17741990
106Abnormal platelet function (HP:0011869)2.17741990
107Stomatitis (HP:0010280)2.17650098
108Thoracic kyphosis (HP:0002942)2.16715933
109Amyloidosis (HP:0011034)2.15579982
110Autoimmune thrombocytopenia (HP:0001973)2.15018756
111Metabolic acidosis (HP:0001942)2.14962499
112Urticaria (HP:0001025)2.14640648
113Vertebral compression fractures (HP:0002953)2.12806357
114Recurrent skin infections (HP:0001581)2.11926975
115Interstitial pulmonary disease (HP:0006530)2.11611809
116Increased IgE level (HP:0003212)2.11317460
117Thrombophlebitis (HP:0004418)2.10951790
118Gingivitis (HP:0000230)2.10533044
119Tetraparesis (HP:0002273)2.09120335
120Microcytic anemia (HP:0001935)2.07142340
121Purpura (HP:0000979)2.06850160
122Agnosia (HP:0010524)2.04993774
123Hypoglycemic seizures (HP:0002173)2.04014208
124Personality changes (HP:0000751)2.03378829
125Hematochezia (HP:0002573)2.03129783
126Abnormality of the vasculature of the conjunctiva (HP:0008054)2.02592351
127Cardiomegaly (HP:0001640)1.98852163
128Petechiae (HP:0000967)1.98785018
129Bone pain (HP:0002653)1.98474002
130Keratoconjunctivitis sicca (HP:0001097)1.98208531
131Pancreatitis (HP:0001733)1.97551485
132Late onset (HP:0003584)1.97005734
133Metaphyseal irregularity (HP:0003025)1.96655612
134Sensorimotor neuropathy (HP:0007141)1.96523668
135Gangrene (HP:0100758)1.96317476
136Delayed CNS myelination (HP:0002188)1.94946755
137Spastic diplegia (HP:0001264)1.94721191
138Abnormality of serum amino acid levels (HP:0003112)1.94493918
139Nephritis (HP:0000123)1.94332729
140Prolonged bleeding time (HP:0003010)1.94023035
141Pulmonary infiltrates (HP:0002113)1.94013100
142Abnormality of the periventricular white matter (HP:0002518)1.93350319
143Inappropriate behavior (HP:0000719)1.93113779
144Dementia (HP:0000726)1.92411342
145Conjunctival telangiectasia (HP:0000524)1.89818374
146Pathologic fracture (HP:0002756)1.89478185
147Prolonged neonatal jaundice (HP:0006579)1.80621403
148Hypertensive crisis (HP:0100735)1.78389670
149Hemoptysis (HP:0002105)1.77456112
150Peripheral demyelination (HP:0011096)1.77398757
151Paralysis (HP:0003470)1.77367606
152Basal ganglia calcification (HP:0002135)1.75821404
153Polyneuropathy (HP:0001271)1.75274227
154Recurrent viral infections (HP:0004429)1.74468892
155Vasculitis (HP:0002633)1.74426452
156Malnutrition (HP:0004395)1.74078693
157Keratoconjunctivitis (HP:0001096)1.70380813
158Gastrointestinal infarctions (HP:0005244)1.69893393
159Abnormality of the lumbar spine (HP:0100712)1.69507200
160Recurrent fungal infections (HP:0002841)1.69196649
161J-shaped sella turcica (HP:0002680)1.69075702
162Hypergammaglobulinemia (HP:0010702)1.64616342

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN14.30674826
2TAOK33.78047820
3BCKDK3.55386697
4TBK12.80492178
5PRPF4B2.67898765
6TAOK22.53668491
7TYK22.51157721
8NME22.47775567
9GRK72.38846705
10IRAK32.26404086
11KIT2.19315275
12FGFR42.13839698
13PKN22.12931196
14TRIB32.12343658
15FLT32.11242809
16TGFBR22.02950457
17PBK2.00054225
18BLK1.98551978
19DDR21.93082976
20MAP2K31.92250600
21IRAK41.83864556
22MAP4K11.81278478
23SIK11.75558671
24NEK91.70433894
25MAP3K141.69006142
26TAOK11.64215847
27IKBKE1.63924660
28ABL21.62041840
29FGR1.59451849
30BMPR21.57614903
31INSRR1.49701525
32ZAP701.47432038
33JAK21.41288978
34KDR1.40992697
35MST1R1.39875161
36JAK31.38137240
37SCYL21.35820335
38JAK11.34217452
39PIM21.33497146
40RIPK41.32436249
41BTK1.32413537
42MOS1.31550232
43CSF1R1.31483542
44MAP3K31.28998295
45MAP3K111.23738303
46PIK3CG1.18769502
47TEC1.18330973
48EIF2AK11.17583124
49IKBKB1.17203642
50MAPK111.17173293
51PTK61.12866971
52STK41.08863023
53CDC42BPA1.04654183
54SYK1.04137232
55ARAF0.96057478
56LRRK20.93282799
57MAP3K60.91547099
58EPHB10.91081222
59RPS6KA40.89646401
60PIM10.89564854
61TESK20.89289358
62KSR20.89264321
63LYN0.88709868
64TESK10.87829830
65CSK0.86421870
66FES0.85831394
67CDK60.84901010
68ACVR1B0.83145049
69IRAK20.81000755
70MATK0.78292642
71MAP3K100.78061981
72CLK10.76458872
73MAPKAPK30.73724129
74CAMK1D0.72235418
75MAP3K50.71052884
76TIE10.70482565
77GRK60.69127197
78STK100.68881985
79ERBB40.68100041
80MAP3K10.67095732
81IRAK10.66200065
82DYRK1B0.65764540
83RIPK10.63592162
84PAK40.61650956
85MAP3K20.60168873
86EIF2AK30.59670133
87MAP2K60.59508506
88HCK0.59129662
89LCK0.58400190
90MAPK40.55405535
91RPS6KL10.55334444
92RPS6KC10.55334444
93EGFR0.54711557
94PDGFRA0.54008912
95ITK0.53209111
96PDK20.51854883
97DYRK30.51452674
98PRKAA20.51008145
99PRKCD0.50678871
100STK160.50154483
101CAMKK20.49741666
102CHUK0.49109289
103ABL10.49089966
104EPHA30.46773577
105TRPM70.44551684
106SIK30.44442321
107ICK0.44222185
108PDPK10.42605038
109MARK30.42169751
110ADRBK20.41628785
111CDK40.40323937
112BMX0.39922977
113PRKG20.37548786
114MAPK150.37419481
115ERBB20.37359457
116RPS6KA60.37053056
117MAP3K80.36675756
118MAP3K130.36666688
119MAPK120.36464154
120TGFBR10.36426070
121TXK0.36367263
122RAF10.35807748
123MAPKAPK20.35112192
124RPS6KA20.34929408
125HIPK20.34723849
126PRKACG0.34206646
127IGF1R0.34204804
128LATS20.34116859
129TLK10.32712905
130MAP2K20.32651786
131PDK10.31783851
132EEF2K0.31446026
133GSK3A0.31404293
134FGFR30.31249259
135BRSK20.30859061

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary bile acid biosynthesis_Homo sapiens_hsa001204.06855161
2Ascorbate and aldarate metabolism_Homo sapiens_hsa000533.18981660
3Complement and coagulation cascades_Homo sapiens_hsa046102.90795781
4Nitrogen metabolism_Homo sapiens_hsa009102.84551462
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.69030064
6Staphylococcus aureus infection_Homo sapiens_hsa051502.63800620
7Pentose and glucuronate interconversions_Homo sapiens_hsa000402.56559127
8Rheumatoid arthritis_Homo sapiens_hsa053232.50885057
9Arginine biosynthesis_Homo sapiens_hsa002202.50632567
10Fatty acid degradation_Homo sapiens_hsa000712.40224415
11Tryptophan metabolism_Homo sapiens_hsa003802.37449576
12Asthma_Homo sapiens_hsa053102.33969139
13Caffeine metabolism_Homo sapiens_hsa002322.25938604
14Allograft rejection_Homo sapiens_hsa053302.10918744
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.09911391
16Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09840518
17Peroxisome_Homo sapiens_hsa041462.05943462
18Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.04640082
19Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008602.04018028
20Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.02288915
21Histidine metabolism_Homo sapiens_hsa003401.85813589
22Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.83140654
23PPAR signaling pathway_Homo sapiens_hsa033201.81035877
24Drug metabolism - other enzymes_Homo sapiens_hsa009831.78670654
25NOD-like receptor signaling pathway_Homo sapiens_hsa046211.72240554
26Graft-versus-host disease_Homo sapiens_hsa053321.70409107
27Chemical carcinogenesis_Homo sapiens_hsa052041.70122028
28Selenocompound metabolism_Homo sapiens_hsa004501.69365143
29beta-Alanine metabolism_Homo sapiens_hsa004101.65154852
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.63598187
31TNF signaling pathway_Homo sapiens_hsa046681.62568707
32Autoimmune thyroid disease_Homo sapiens_hsa053201.62302831
33Folate biosynthesis_Homo sapiens_hsa007901.61568151
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.60792870
35Intestinal immune network for IgA production_Homo sapiens_hsa046721.59094945
36Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.56496247
37Propanoate metabolism_Homo sapiens_hsa006401.55065508
38Steroid hormone biosynthesis_Homo sapiens_hsa001401.52675878
39Toxoplasmosis_Homo sapiens_hsa051451.49688756
40Fatty acid metabolism_Homo sapiens_hsa012121.48593807
41Retinol metabolism_Homo sapiens_hsa008301.44820526
42Butanoate metabolism_Homo sapiens_hsa006501.43070342
43ABC transporters_Homo sapiens_hsa020101.41649461
44Starch and sucrose metabolism_Homo sapiens_hsa005001.40293041
45Salmonella infection_Homo sapiens_hsa051321.39858805
46Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.34511288
47Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.33662786
48Sulfur relay system_Homo sapiens_hsa041221.31129919
49Glycosaminoglycan degradation_Homo sapiens_hsa005311.28492681
50Type I diabetes mellitus_Homo sapiens_hsa049401.28167059
51Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.25435778
52Maturity onset diabetes of the young_Homo sapiens_hsa049501.24954857
53Phenylalanine metabolism_Homo sapiens_hsa003601.23850620
54Sulfur metabolism_Homo sapiens_hsa009201.23635197
55African trypanosomiasis_Homo sapiens_hsa051431.20907785
56Bile secretion_Homo sapiens_hsa049761.16259536
57B cell receptor signaling pathway_Homo sapiens_hsa046621.16197220
58Lysosome_Homo sapiens_hsa041421.15585760
592-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.12654686
60Collecting duct acid secretion_Homo sapiens_hsa049661.12560319
61Cysteine and methionine metabolism_Homo sapiens_hsa002701.11331606
62Acute myeloid leukemia_Homo sapiens_hsa052211.09881557
63Fat digestion and absorption_Homo sapiens_hsa049751.07809368
64Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.05761672
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.05675504
66Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.04454018
67Other glycan degradation_Homo sapiens_hsa005111.02831515
68Tyrosine metabolism_Homo sapiens_hsa003501.01964182
69Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.01033508
70Carbon metabolism_Homo sapiens_hsa012000.99586290
71Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.99257967
72Sphingolipid metabolism_Homo sapiens_hsa006000.98378457
73Herpes simplex infection_Homo sapiens_hsa051680.97607749
74Viral myocarditis_Homo sapiens_hsa054160.95714133
75Amoebiasis_Homo sapiens_hsa051460.95357823
76Hepatitis C_Homo sapiens_hsa051600.94617272
77Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.94604709
78Steroid biosynthesis_Homo sapiens_hsa001000.93331896
79Fatty acid elongation_Homo sapiens_hsa000620.92799393
80Pyruvate metabolism_Homo sapiens_hsa006200.92493197
81Bladder cancer_Homo sapiens_hsa052190.91513580
82Pentose phosphate pathway_Homo sapiens_hsa000300.89704648
83Biosynthesis of amino acids_Homo sapiens_hsa012300.89197253
84Chemokine signaling pathway_Homo sapiens_hsa040620.89115543
85Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.86352152
86Shigellosis_Homo sapiens_hsa051310.86212365
87Jak-STAT signaling pathway_Homo sapiens_hsa046300.84015012
88Vitamin digestion and absorption_Homo sapiens_hsa049770.83197666
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.79376180
90Glutathione metabolism_Homo sapiens_hsa004800.74081055
91Arginine and proline metabolism_Homo sapiens_hsa003300.73614524
92Hepatitis B_Homo sapiens_hsa051610.72689422
93Mineral absorption_Homo sapiens_hsa049780.70269445
94One carbon pool by folate_Homo sapiens_hsa006700.69806254
95Leishmaniasis_Homo sapiens_hsa051400.69651760
96Vibrio cholerae infection_Homo sapiens_hsa051100.67075796
97Galactose metabolism_Homo sapiens_hsa000520.66439521
98Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.65736541
99Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.63650939
100AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.63164037
101Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.61962872
102Glycerolipid metabolism_Homo sapiens_hsa005610.61123156
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.60918402
104Legionellosis_Homo sapiens_hsa051340.60486654
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.59063867
106Vitamin B6 metabolism_Homo sapiens_hsa007500.59013162
107Toll-like receptor signaling pathway_Homo sapiens_hsa046200.58688511
108VEGF signaling pathway_Homo sapiens_hsa043700.58393550
109Platelet activation_Homo sapiens_hsa046110.55977443
110Prolactin signaling pathway_Homo sapiens_hsa049170.54989453
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.51712739
112Lysine degradation_Homo sapiens_hsa003100.51516658
113Pertussis_Homo sapiens_hsa051330.51373108
114Pancreatic cancer_Homo sapiens_hsa052120.50973142
115Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50848409
116Chronic myeloid leukemia_Homo sapiens_hsa052200.50702594
117Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.49684353
118Adipocytokine signaling pathway_Homo sapiens_hsa049200.47559017
119Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.46999401
120RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.46863457
121Osteoclast differentiation_Homo sapiens_hsa043800.45408325
122Malaria_Homo sapiens_hsa051440.45079761
123Metabolic pathways_Homo sapiens_hsa011000.44037430
124Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.43918288
125Leukocyte transendothelial migration_Homo sapiens_hsa046700.40579413
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.40391430
127Arachidonic acid metabolism_Homo sapiens_hsa005900.39907136
128Insulin resistance_Homo sapiens_hsa049310.37943834
129Tuberculosis_Homo sapiens_hsa051520.37862383
130Systemic lupus erythematosus_Homo sapiens_hsa053220.37585831
131HIF-1 signaling pathway_Homo sapiens_hsa040660.37169774
132Epstein-Barr virus infection_Homo sapiens_hsa051690.35370696
133Antigen processing and presentation_Homo sapiens_hsa046120.34838310
134Prion diseases_Homo sapiens_hsa050200.34710565
135Phagosome_Homo sapiens_hsa041450.34422042
136T cell receptor signaling pathway_Homo sapiens_hsa046600.33345636
137Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.32915855
138Renal cell carcinoma_Homo sapiens_hsa052110.32673533
139Neurotrophin signaling pathway_Homo sapiens_hsa047220.31893133
140Endocytosis_Homo sapiens_hsa041440.31641936
141Transcriptional misregulation in cancer_Homo sapiens_hsa052020.29743065
142NF-kappa B signaling pathway_Homo sapiens_hsa040640.29253258
143alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.26449692
144Fructose and mannose metabolism_Homo sapiens_hsa000510.25673813
145Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25000513
146Protein export_Homo sapiens_hsa030600.22746951
147Hematopoietic cell lineage_Homo sapiens_hsa046400.22052270
148Measles_Homo sapiens_hsa051620.22026573
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.19137985
150Renin-angiotensin system_Homo sapiens_hsa046140.19062105
151Linoleic acid metabolism_Homo sapiens_hsa005910.19031500
152HTLV-I infection_Homo sapiens_hsa051660.18474913
153Type II diabetes mellitus_Homo sapiens_hsa049300.17982529
154Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.17933175
155Influenza A_Homo sapiens_hsa051640.16856730
156Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.15899610
157Apoptosis_Homo sapiens_hsa042100.13813923

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »