CREG2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.27162487
2positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.92426505
3synaptic vesicle maturation (GO:0016188)5.83779239
4locomotory exploration behavior (GO:0035641)5.77923084
5regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.68501675
6vocalization behavior (GO:0071625)5.67655812
7synaptic vesicle exocytosis (GO:0016079)5.59143827
8glutamate secretion (GO:0014047)5.41534792
9synaptic vesicle docking involved in exocytosis (GO:0016081)5.32708019
10regulation of glutamate receptor signaling pathway (GO:1900449)5.32561396
11ionotropic glutamate receptor signaling pathway (GO:0035235)5.26514546
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.13252820
13regulation of synaptic vesicle exocytosis (GO:2000300)5.07961452
14protein localization to synapse (GO:0035418)5.06811903
15regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.78493951
16exploration behavior (GO:0035640)4.77260238
17neuron cell-cell adhesion (GO:0007158)4.72897224
18regulation of neuronal synaptic plasticity (GO:0048168)4.71046507
19regulation of long-term neuronal synaptic plasticity (GO:0048169)4.69719787
20glutamate receptor signaling pathway (GO:0007215)4.63229920
21regulation of synaptic vesicle transport (GO:1902803)4.62292211
22synaptic transmission, glutamatergic (GO:0035249)4.51065783
23neuronal action potential propagation (GO:0019227)4.50900415
24neurotransmitter-gated ion channel clustering (GO:0072578)4.32369250
25neurotransmitter secretion (GO:0007269)4.28988676
26neuron-neuron synaptic transmission (GO:0007270)4.28869699
27central nervous system myelination (GO:0022010)4.22275437
28axon ensheathment in central nervous system (GO:0032291)4.22275437
29regulation of excitatory postsynaptic membrane potential (GO:0060079)4.14580946
30long-term memory (GO:0007616)4.14166279
31dendritic spine morphogenesis (GO:0060997)3.98249962
32positive regulation of membrane potential (GO:0045838)3.97843083
33regulation of synaptic plasticity (GO:0048167)3.95472106
34regulation of synapse structural plasticity (GO:0051823)3.94887083
35neuronal ion channel clustering (GO:0045161)3.93585755
36regulation of voltage-gated calcium channel activity (GO:1901385)3.93088636
37long-term synaptic potentiation (GO:0060291)3.92998295
38regulation of postsynaptic membrane potential (GO:0060078)3.92936751
39proline transport (GO:0015824)3.92831377
40gamma-aminobutyric acid signaling pathway (GO:0007214)3.80699517
41cerebellar granule cell differentiation (GO:0021707)3.80249184
42membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.77074597
43negative regulation of dendrite morphogenesis (GO:0050774)3.76734928
44synaptic vesicle endocytosis (GO:0048488)3.72444671
45negative regulation of synaptic transmission, GABAergic (GO:0032229)3.72369818
46potassium ion import (GO:0010107)3.71729105
47amino acid import (GO:0043090)3.70878994
48cellular potassium ion homeostasis (GO:0030007)3.69503188
49positive regulation of neurotransmitter secretion (GO:0001956)3.69222891
50potassium ion homeostasis (GO:0055075)3.67553336
51regulation of dendritic spine morphogenesis (GO:0061001)3.67396765
52neuron recognition (GO:0008038)3.66506730
53response to histamine (GO:0034776)3.61507322
54presynaptic membrane assembly (GO:0097105)3.60758121
55layer formation in cerebral cortex (GO:0021819)3.59801209
56postsynaptic membrane organization (GO:0001941)3.59341307
57positive regulation of synapse maturation (GO:0090129)3.57385971
58neurotransmitter transport (GO:0006836)3.54437914
59regulation of neurotransmitter secretion (GO:0046928)3.52208706
60G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.52062272
61neurotransmitter uptake (GO:0001504)3.51373354
62regulation of synaptic transmission, glutamatergic (GO:0051966)3.51134569
63positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.47321592
64gamma-aminobutyric acid transport (GO:0015812)3.46904668
65positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.42827150
66behavioral defense response (GO:0002209)3.41177345
67behavioral fear response (GO:0001662)3.41177345
68positive regulation of neurotransmitter transport (GO:0051590)3.38839082
69serotonin metabolic process (GO:0042428)3.38776733
70innervation (GO:0060384)3.38119663
71regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.37951832
72axonal fasciculation (GO:0007413)3.30988953
73presynaptic membrane organization (GO:0097090)3.30688431
74dendritic spine organization (GO:0097061)3.28471822
75transmission of nerve impulse (GO:0019226)3.28229371
76L-amino acid import (GO:0043092)3.26876559
77G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.26588185
78regulation of neurotransmitter levels (GO:0001505)3.26570031
79neuromuscular synaptic transmission (GO:0007274)3.26483063
80positive regulation of synaptic transmission, GABAergic (GO:0032230)3.26317894
81regulation of vesicle fusion (GO:0031338)3.26064427
82detection of calcium ion (GO:0005513)3.25198130
83membrane depolarization (GO:0051899)3.24760244
84startle response (GO:0001964)3.23985999
85regulation of dendritic spine development (GO:0060998)3.23528192
86activation of protein kinase A activity (GO:0034199)3.23303719
87regulation of neurotransmitter transport (GO:0051588)3.22330998
88learning (GO:0007612)3.21901652
89cellular sodium ion homeostasis (GO:0006883)3.21510234
90fear response (GO:0042596)3.20808011
91negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.19593277
92positive regulation of synaptic transmission (GO:0050806)3.18559647
93regulation of synaptic transmission (GO:0050804)3.17694890
94behavioral response to cocaine (GO:0048148)3.16940540
95primary amino compound metabolic process (GO:1901160)3.16141097
96vesicle transport along microtubule (GO:0047496)3.14847272
97neuromuscular process controlling balance (GO:0050885)3.14694351
98regulation of synapse maturation (GO:0090128)3.14403427
99cerebellar Purkinje cell differentiation (GO:0021702)3.13133394
100acidic amino acid transport (GO:0015800)3.11566562
101synaptic vesicle transport (GO:0048489)3.11480718
102establishment of synaptic vesicle localization (GO:0097480)3.11480718
103sodium ion export (GO:0071436)3.10528763
104positive regulation of dendritic spine development (GO:0060999)3.08265632
105synaptic transmission (GO:0007268)3.07448233
106cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.07051609
107long term synaptic depression (GO:0060292)3.07051229
108regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.05786002
109neuromuscular process controlling posture (GO:0050884)3.05396165
110adult walking behavior (GO:0007628)3.05107306
111membrane hyperpolarization (GO:0060081)3.02557032
112positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.01740307
113chemosensory behavior (GO:0007635)2.99850549
114positive regulation of dendritic spine morphogenesis (GO:0061003)2.99439117
115response to auditory stimulus (GO:0010996)2.98913540
116membrane depolarization during action potential (GO:0086010)2.98343165
117regulation of glutamate secretion (GO:0014048)2.97494199
118intraspecies interaction between organisms (GO:0051703)2.94206649
119social behavior (GO:0035176)2.94206649
120cell communication by electrical coupling (GO:0010644)2.94064565
121auditory behavior (GO:0031223)2.93471664
122regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.91610164

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.18691720
2GBX2_23144817_ChIP-Seq_PC3_Human3.91004989
3* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.18461350
4JARID2_20064375_ChIP-Seq_MESCs_Mouse3.16101452
5* SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.07292479
6RNF2_18974828_ChIP-Seq_MESCs_Mouse2.72833532
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.72833532
8* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.72498378
9REST_21632747_ChIP-Seq_MESCs_Mouse2.72132794
10JARID2_20075857_ChIP-Seq_MESCs_Mouse2.65430447
11SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.60420439
12* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.50567271
13* RARB_27405468_Chip-Seq_BRAIN_Mouse2.50127849
14EZH2_27304074_Chip-Seq_ESCs_Mouse2.49844828
15* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.48938523
16SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.46349157
17DROSHA_22980978_ChIP-Seq_HELA_Human2.40279692
18EED_16625203_ChIP-ChIP_MESCs_Mouse2.34637681
19* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.22669234
20RNF2_27304074_Chip-Seq_ESCs_Mouse2.19921420
21* EZH2_27294783_Chip-Seq_ESCs_Mouse2.17090255
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.13342550
23IKZF1_21737484_ChIP-ChIP_HCT116_Human2.12335775
24ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.94458932
25CTBP2_25329375_ChIP-Seq_LNCAP_Human1.87811295
26CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.87346494
27AR_21572438_ChIP-Seq_LNCaP_Human1.85250254
28GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.83309975
29CTBP1_25329375_ChIP-Seq_LNCAP_Human1.82800868
30SMAD4_21799915_ChIP-Seq_A2780_Human1.78055168
31NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.75246285
32SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.74806877
33TAF15_26573619_Chip-Seq_HEK293_Human1.73915133
34MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.71087334
35ZFP57_27257070_Chip-Seq_ESCs_Mouse1.69202598
36P300_19829295_ChIP-Seq_ESCs_Human1.57641149
37TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56795005
38EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52598542
39SMAD_19615063_ChIP-ChIP_OVARY_Human1.49107818
40* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.45397584
41GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45358560
42SMAD3_21741376_ChIP-Seq_EPCs_Human1.42434652
43ERG_21242973_ChIP-ChIP_JURKAT_Human1.39822966
44PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.39726216
45SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.39549845
46AR_25329375_ChIP-Seq_VCAP_Human1.38046258
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.37829543
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34988557
49ZNF274_21170338_ChIP-Seq_K562_Hela1.32609935
50CBX2_27304074_Chip-Seq_ESCs_Mouse1.30178941
51SOX2_21211035_ChIP-Seq_LN229_Gbm1.28906484
52* RING1B_27294783_Chip-Seq_ESCs_Mouse1.26564808
53TOP2B_26459242_ChIP-Seq_MCF-7_Human1.26318263
54OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25890389
55STAT3_23295773_ChIP-Seq_U87_Human1.25862551
56PIAS1_25552417_ChIP-Seq_VCAP_Human1.24874320
57THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.24693368
58BMI1_23680149_ChIP-Seq_NPCS_Mouse1.20450962
59SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19966442
60RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.18252829
61IGF1R_20145208_ChIP-Seq_DFB_Human1.17900802
62FUS_26573619_Chip-Seq_HEK293_Human1.17391451
63TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.16555578
64* AR_19668381_ChIP-Seq_PC3_Human1.15998904
65POU3F2_20337985_ChIP-ChIP_501MEL_Human1.15469687
66TCF4_23295773_ChIP-Seq_U87_Human1.12836332
67PRDM14_20953172_ChIP-Seq_ESCs_Human1.11599007
68VDR_22108803_ChIP-Seq_LS180_Human1.11516959
69P53_22127205_ChIP-Seq_FIBROBLAST_Human1.11134341
70ARNT_22903824_ChIP-Seq_MCF-7_Human1.11067836
71ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09786331
72RNF2_27304074_Chip-Seq_NSC_Mouse1.09621037
73WT1_25993318_ChIP-Seq_PODOCYTE_Human1.09550678
74TP53_16413492_ChIP-PET_HCT116_Human1.08986669
75CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07651227
76TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07189895
77AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.07003489
78PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.05066750
79UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.03844280
80RING1B_27294783_Chip-Seq_NPCs_Mouse1.03767615
81YAP1_20516196_ChIP-Seq_MESCs_Mouse1.03037530
82AHR_22903824_ChIP-Seq_MCF-7_Human1.02718046
83DNAJC2_21179169_ChIP-ChIP_NT2_Human1.02217510
84RXR_22108803_ChIP-Seq_LS180_Human1.01734125
85RUNX2_22187159_ChIP-Seq_PCA_Human1.00823619
86MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.00712568
87JUN_21703547_ChIP-Seq_K562_Human1.00197236
88TP53_18474530_ChIP-ChIP_U2OS_Human0.99912396
89MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.99421556
90GATA1_26923725_Chip-Seq_HPCs_Mouse0.98943663
91* NR3C1_21868756_ChIP-Seq_MCF10A_Human0.98919424
92VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.98902379
93LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.96391165
94ER_23166858_ChIP-Seq_MCF-7_Human0.96134277
95* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96048664
96CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94061912
97CTCF_27219007_Chip-Seq_Bcells_Human0.93491001
98* NANOG_18555785_Chip-Seq_ESCs_Mouse0.93391951
99RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.93033711
100SMAD3_21741376_ChIP-Seq_HESCs_Human0.92678875
101SMAD3_21741376_ChIP-Seq_ESCs_Human0.91659152
102ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.90907314
103CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.90716625
104TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90502858
105POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.90502858
106* FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.89621386
107TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.88741256
108SMAD4_21741376_ChIP-Seq_HESCs_Human0.88624253
109WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.87618949
110FLI1_21867929_ChIP-Seq_TH2_Mouse0.85422174
111MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.85134933
112KDM2B_26808549_Chip-Seq_REH_Human0.84197141
113SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.82546843
114TET1_21490601_ChIP-Seq_MESCs_Mouse0.81692802
115CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.80806266

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity7.19253292
2MP0003880_abnormal_central_pattern5.57708205
3MP0003635_abnormal_synaptic_transmissio4.34259750
4MP0004270_analgesia3.74385401
5MP0009745_abnormal_behavioral_response3.65088661
6MP0002063_abnormal_learning/memory/cond3.54341359
7MP0002064_seizures3.34383348
8MP0001968_abnormal_touch/_nociception3.06076376
9MP0002572_abnormal_emotion/affect_behav2.99984507
10MP0009046_muscle_twitch2.99971511
11MP0001486_abnormal_startle_reflex2.68487936
12MP0005423_abnormal_somatic_nervous2.67501198
13MP0002272_abnormal_nervous_system2.65745499
14MP0001501_abnormal_sleep_pattern2.61445935
15MP0002822_catalepsy2.58329150
16MP0002734_abnormal_mechanical_nocicepti2.48172025
17MP0002736_abnormal_nociception_after2.43251555
18MP0002735_abnormal_chemical_nociception2.23082689
19MP0001440_abnormal_grooming_behavior2.16280874
20MP0009780_abnormal_chondrocyte_physiolo2.04290936
21MP0002067_abnormal_sensory_capabilities1.93482332
22MP0005646_abnormal_pituitary_gland1.88994071
23MP0002733_abnormal_thermal_nociception1.86720681
24MP0001970_abnormal_pain_threshold1.85934619
25MP0003329_amyloid_beta_deposits1.84938120
26MP0003879_abnormal_hair_cell1.84119680
27MP0004858_abnormal_nervous_system1.77613968
28MP0002557_abnormal_social/conspecific_i1.74632486
29MP0004811_abnormal_neuron_physiology1.72992084
30MP0000778_abnormal_nervous_system1.72198343
31MP0002184_abnormal_innervation1.72032836
32MP0008569_lethality_at_weaning1.69622750
33MP0003787_abnormal_imprinting1.66969403
34MP0005386_behavior/neurological_phenoty1.66275564
35MP0004924_abnormal_behavior1.66275564
36MP0006276_abnormal_autonomic_nervous1.63060343
37MP0008877_abnormal_DNA_methylation1.52266932
38MP0002909_abnormal_adrenal_gland1.50622364
39MP0005645_abnormal_hypothalamus_physiol1.44022210
40MP0004147_increased_porphyrin_level1.43128865
41MP0000955_abnormal_spinal_cord1.42928703
42MP0003633_abnormal_nervous_system1.39588007
43MP0002066_abnormal_motor_capabilities/c1.38980200
44MP0003123_paternal_imprinting1.36541871
45MP0001905_abnormal_dopamine_level1.35755661
46MP0001984_abnormal_olfaction1.35582830
47MP0002882_abnormal_neuron_morphology1.35056840
48MP0001529_abnormal_vocalization1.30535951
49MP0004885_abnormal_endolymph1.27818675
50MP0001502_abnormal_circadian_rhythm1.26519630
51MP0003631_nervous_system_phenotype1.17697073
52MP0001188_hyperpigmentation1.17373805
53MP0004142_abnormal_muscle_tone1.09813941
54MP0003075_altered_response_to1.09350376
55MP0003122_maternal_imprinting1.08358956
56MP0002638_abnormal_pupillary_reflex1.04902349
57MP0001986_abnormal_taste_sensitivity1.03273317
58MP0010386_abnormal_urinary_bladder1.02998239
59MP0002152_abnormal_brain_morphology1.02148312
60MP0008872_abnormal_physiological_respon0.99217963
61MP0008874_decreased_physiological_sensi0.93921190
62MP0002069_abnormal_eating/drinking_beha0.91905774
63MP0004742_abnormal_vestibular_system0.91544919
64MP0000604_amyloidosis0.90498489
65MP0000569_abnormal_digit_pigmentation0.89769317
66MP0000751_myopathy0.89398946
67MP0001963_abnormal_hearing_physiology0.89180792
68MP0002229_neurodegeneration0.89049263
69MP0003121_genomic_imprinting0.88187108
70MP0003690_abnormal_glial_cell0.85444990
71MP0005535_abnormal_body_temperature0.84915291
72MP0004510_myositis0.84891013
73MP0001177_atelectasis0.83988136
74MP0005551_abnormal_eye_electrophysiolog0.83022500
75MP0005409_darkened_coat_color0.82658729
76MP0002837_dystrophic_cardiac_calcinosis0.80166522
77MP0004085_abnormal_heartbeat0.78936207
78MP0002876_abnormal_thyroid_physiology0.77894824
79MP0004484_altered_response_of0.76991797
80MP0003632_abnormal_nervous_system0.76588169
81MP0003634_abnormal_glial_cell0.76273294
82MP0004145_abnormal_muscle_electrophysio0.74235723
83MP0000920_abnormal_myelination0.73160133
84MP0001485_abnormal_pinna_reflex0.70611485
85MP0005167_abnormal_blood-brain_barrier0.68128881
86MP0001664_abnormal_digestion0.68017359
87MP0002752_abnormal_somatic_nervous0.65520805
88MP0004215_abnormal_myocardial_fiber0.64273129
89MP0000631_abnormal_neuroendocrine_gland0.64252295
90MP0003172_abnormal_lysosome_physiology0.63467934
91MP0005171_absent_coat_pigmentation0.63235946
92MP0004043_abnormal_pH_regulation0.62827961
93MP0003137_abnormal_impulse_conducting0.62423643
94MP0004130_abnormal_muscle_cell0.60769821
95MP0001348_abnormal_lacrimal_gland0.59933266
96MP0001346_abnormal_lacrimal_gland0.58677276
97MP0005394_taste/olfaction_phenotype0.58345630
98MP0005499_abnormal_olfactory_system0.58345630
99MP0002090_abnormal_vision0.58260671
100MP0000013_abnormal_adipose_tissue0.57269825
101MP0008961_abnormal_basal_metabolism0.54437034
102MP0002653_abnormal_ependyma_morphology0.52883655
103MP0008875_abnormal_xenobiotic_pharmacok0.50300736
104MP0005166_decreased_susceptibility_to0.50218379
105MP0003861_abnormal_nervous_system0.50141216
106MP0005623_abnormal_meninges_morphology0.50137826
107MP0001943_abnormal_respiration0.49931765
108MP0000026_abnormal_inner_ear0.49863153
109MP0005253_abnormal_eye_physiology0.49204374
110MP0002160_abnormal_reproductive_system0.47774945
111MP0000639_abnormal_adrenal_gland0.47347911
112MP0010769_abnormal_survival0.46693932
113MP0004133_heterotaxia0.46559450
114MP0001765_abnormal_ion_homeostasis0.45883434
115MP0003956_abnormal_body_size0.45683889
116MP0010768_mortality/aging0.45629053
117MP0004233_abnormal_muscle_weight0.45548160
118MP0010770_preweaning_lethality0.44785447
119MP0002082_postnatal_lethality0.44785447

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)8.95451443
2Myokymia (HP:0002411)7.27195946
3Focal seizures (HP:0007359)6.21136345
4Visual hallucinations (HP:0002367)5.51949115
5Epileptic encephalopathy (HP:0200134)5.51352896
6Atonic seizures (HP:0010819)5.04125825
7Febrile seizures (HP:0002373)5.00266555
8Absence seizures (HP:0002121)4.64328762
9Progressive cerebellar ataxia (HP:0002073)4.47560483
10Dialeptic seizures (HP:0011146)4.34505980
11Generalized tonic-clonic seizures (HP:0002069)4.21612200
12Hyperventilation (HP:0002883)4.14639529
13Action tremor (HP:0002345)3.82531339
14Broad-based gait (HP:0002136)3.77399597
15Impaired vibration sensation in the lower limbs (HP:0002166)3.60633956
16Poor eye contact (HP:0000817)3.57575026
17Supranuclear gaze palsy (HP:0000605)3.54095433
18Gaze-evoked nystagmus (HP:0000640)3.48905767
19Amblyopia (HP:0000646)3.37888562
20Depression (HP:0000716)3.30857707
21Dysmetria (HP:0001310)3.26920976
22Dysdiadochokinesis (HP:0002075)3.16722203
23Anxiety (HP:0000739)3.13771025
24Urinary bladder sphincter dysfunction (HP:0002839)3.13279635
25Impaired social interactions (HP:0000735)3.08747839
26Abnormal social behavior (HP:0012433)3.08747839
27Ankle clonus (HP:0011448)3.08438728
28Truncal ataxia (HP:0002078)3.07232512
29Postural instability (HP:0002172)3.05936656
30Mutism (HP:0002300)3.02290984
31Excessive salivation (HP:0003781)2.92598502
32Drooling (HP:0002307)2.92598502
33Cerebral hypomyelination (HP:0006808)2.92288380
34Abnormal eating behavior (HP:0100738)2.91346750
35Papilledema (HP:0001085)2.84916241
36Cerebral inclusion bodies (HP:0100314)2.77134165
37Progressive inability to walk (HP:0002505)2.70080957
38Diplopia (HP:0000651)2.69375508
39Abnormality of binocular vision (HP:0011514)2.69375508
40Absent speech (HP:0001344)2.69369262
41Epileptiform EEG discharges (HP:0011182)2.67821049
42Urinary urgency (HP:0000012)2.66099129
43Genetic anticipation (HP:0003743)2.65733417
44Impaired smooth pursuit (HP:0007772)2.63427893
45Neurofibrillary tangles (HP:0002185)2.62784634
46Stereotypic behavior (HP:0000733)2.60843686
47Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.59621424
48Bradykinesia (HP:0002067)2.57803678
49Abnormality of the lower motor neuron (HP:0002366)2.52395785
50Torticollis (HP:0000473)2.50040250
51Fetal akinesia sequence (HP:0001989)2.49496994
52Inability to walk (HP:0002540)2.49080168
53Impaired vibratory sensation (HP:0002495)2.47601714
54Hemiparesis (HP:0001269)2.43886374
55EEG with generalized epileptiform discharges (HP:0011198)2.40740338
56Focal dystonia (HP:0004373)2.40350619
57Morphological abnormality of the pyramidal tract (HP:0002062)2.40040108
58Scanning speech (HP:0002168)2.36995161
59Spastic gait (HP:0002064)2.36033617
60Akinesia (HP:0002304)2.35149325
61Tetraplegia (HP:0002445)2.32766016
62Termporal pattern (HP:0011008)2.30975127
63Insidious onset (HP:0003587)2.30975127
64Generalized myoclonic seizures (HP:0002123)2.29847847
65Abnormality of ocular smooth pursuit (HP:0000617)2.28728926
66Intention tremor (HP:0002080)2.28114809
67Spastic tetraparesis (HP:0001285)2.25473897
68Status epilepticus (HP:0002133)2.23702872
69Hypsarrhythmia (HP:0002521)2.22184450
70Sleep apnea (HP:0010535)2.20837768
71Delusions (HP:0000746)2.18422740
72Blue irides (HP:0000635)2.16715516
73Hemiplegia (HP:0002301)2.16261659
74Incomplete penetrance (HP:0003829)2.13985281
75Clonus (HP:0002169)2.13882761
76Protruding tongue (HP:0010808)2.12146053
77Lower limb muscle weakness (HP:0007340)2.11212995
78Abnormality of the corticospinal tract (HP:0002492)2.08205326
79Abnormality of salivation (HP:0100755)2.07959480
80Dysmetric saccades (HP:0000641)2.07687282
81Inappropriate behavior (HP:0000719)2.07592308
82CNS hypomyelination (HP:0003429)2.07463967
83Megalencephaly (HP:0001355)2.06633511
84Polyphagia (HP:0002591)2.05729795
85Dynein arm defect of respiratory motile cilia (HP:0012255)2.03337468
86Absent/shortened dynein arms (HP:0200106)2.03337468
87Ventricular fibrillation (HP:0001663)2.03226530
88Craniofacial dystonia (HP:0012179)2.01565125
89Pheochromocytoma (HP:0002666)2.00990374
90Gait ataxia (HP:0002066)2.00974606
91Increased circulating renin level (HP:0000848)1.99893345
92Spastic tetraplegia (HP:0002510)1.93948268
93Annular pancreas (HP:0001734)1.91078703
94Choreoathetosis (HP:0001266)1.89972677
95Limb dystonia (HP:0002451)1.86776294
96Psychosis (HP:0000709)1.86775814
97Obstructive sleep apnea (HP:0002870)1.85838243
98Neuronal loss in central nervous system (HP:0002529)1.81713580
99Prolonged QT interval (HP:0001657)1.79760931
100Generalized hypopigmentation of hair (HP:0011358)1.78239691
101Widely spaced teeth (HP:0000687)1.78190533
102Lower limb amyotrophy (HP:0007210)1.77873127
103Slow saccadic eye movements (HP:0000514)1.77238048
104Agitation (HP:0000713)1.77180037
105Rigidity (HP:0002063)1.76533299
106Thickened helices (HP:0000391)1.75547360
107Rapidly progressive (HP:0003678)1.74340933
108Neuroendocrine neoplasm (HP:0100634)1.73976361
109Abnormality of saccadic eye movements (HP:0000570)1.73965163
110Syncope (HP:0001279)1.72446414
111Peripheral hypomyelination (HP:0007182)1.72436422
112Abnormal EKG (HP:0003115)1.70800671
113Gait imbalance (HP:0002141)1.70208964
114Decreased number of large peripheral myelinated nerve fibers (HP:0003387)1.68466869
115Retinal dysplasia (HP:0007973)1.67379282
116Degeneration of the lateral corticospinal tracts (HP:0002314)1.66691375
117Paraplegia (HP:0010550)1.66676981
118Amyotrophic lateral sclerosis (HP:0007354)1.66145782
119Apathy (HP:0000741)1.64818146
120Decreased central vision (HP:0007663)1.62254534
121Confusion (HP:0001289)1.62049562

Predicted kinase interactions (KEA)

RankGene SetZ-score
1EPHA44.96300580
2NTRK34.80908839
3MAP3K93.61544059
4MAP3K42.90469556
5RIPK42.71900696
6DAPK22.68688287
7MAP2K72.67781660
8MINK12.55222818
9CASK2.47033353
10MAP3K122.39040934
11MARK12.38729317
12KSR22.05454162
13PAK62.02170657
14DAPK11.93358910
15PLK21.90604582
16PRKD31.90161997
17MAP2K41.87943821
18PRPF4B1.74230754
19NTRK21.73840917
20KSR11.70007304
21ARAF1.65698433
22CAMKK11.64600087
23MAP3K131.64254908
24NTRK11.62661096
25TNIK1.52712146
26CDK51.50957670
27CDK191.50154451
28GRK51.49981826
29SIK21.47664198
30PNCK1.37567593
31MAPK131.33128045
32FES1.30928489
33PRKCG1.30080610
34STK381.24948878
35BMPR21.23042961
36PTK2B1.20180727
37FRK1.16368849
38CAMK2A1.12085159
39MAP3K21.03141089
40RAF10.99765573
41CAMK10.99679228
42CAMK2B0.97154581
43WNK40.94340985
44SIK30.92766861
45UHMK10.90686516
46ADRBK20.89366567
47SGK2230.86991930
48SGK4940.86991930
49CAMKK20.84647306
50CDK180.83835284
51STK390.82938228
52OXSR10.82043766
53NME10.81642811
54CDK150.80072652
55SGK20.78590989
56TYRO30.78551653
57CDK140.76716209
58PRKCH0.76388171
59LATS20.75559492
60CCNB10.74947225
61STK110.73535775
62SGK10.72280450
63CDK11A0.69307060
64MAP3K110.67933927
65PDK10.66784333
66TNK20.66675534
67FGR0.66353280
68DYRK1A0.65722285
69PINK10.65204317
70LIMK10.64996199
71PKN10.64272094
72BMPR1B0.63952030
73SGK30.62181151
74PAK30.62090743
75TAOK10.61344106
76RET0.59124228
77PHKG10.58295642
78PHKG20.58295642
79MAP3K10.57765762
80PDPK10.56786796
81PRKCE0.52335959
82MARK20.51377382
83NEK60.49840767
84INSRR0.49793588
85MAP3K70.49612050
86CSNK1G20.48535193
87CAMK2D0.47015619
88AKT30.46206865
89ALK0.45661830
90PRKCZ0.44229659
91FGFR20.42977567
92RPS6KA30.42889568
93FER0.42617945
94BRAF0.41757083
95CAMK2G0.41584613
96FYN0.41452592
97MAP2K10.40912615
98ADRBK10.40836871
99CAMK40.40406648
100DAPK30.40034368
101PRKACA0.39269087
102LMTK20.38752507
103WNK30.37367297
104MAPK100.36930624
105BRSK10.35498674
106WNK10.34970957
107MAPK120.34822919
108PRKG10.33753364
109CAMK1G0.31750964
110DMPK0.31675534
111MOS0.31366460
112MAP3K60.31198800
113CSNK1A10.30907397
114GRK70.30742492
115CSNK1D0.30721114
116PRKCA0.30497800
117CSNK1E0.30057373
118CSNK1A1L0.29817019
119PRKCB0.28728935
120MUSK0.28187749

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.00502239
2Synaptic vesicle cycle_Homo sapiens_hsa047213.29492121
3Long-term potentiation_Homo sapiens_hsa047202.89192052
4Circadian entrainment_Homo sapiens_hsa047132.80270991
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.79867885
6Olfactory transduction_Homo sapiens_hsa047402.77060470
7Glutamatergic synapse_Homo sapiens_hsa047242.65657755
8GABAergic synapse_Homo sapiens_hsa047272.63555841
9Amphetamine addiction_Homo sapiens_hsa050312.60985196
10Morphine addiction_Homo sapiens_hsa050322.53619187
11Salivary secretion_Homo sapiens_hsa049702.31292545
12Dopaminergic synapse_Homo sapiens_hsa047282.16436855
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.10885881
14Insulin secretion_Homo sapiens_hsa049112.00358114
15Gastric acid secretion_Homo sapiens_hsa049711.94439585
16Cholinergic synapse_Homo sapiens_hsa047251.88181392
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.83657833
18Taste transduction_Homo sapiens_hsa047421.80788432
19Renin secretion_Homo sapiens_hsa049241.78017681
20Serotonergic synapse_Homo sapiens_hsa047261.77010458
21Calcium signaling pathway_Homo sapiens_hsa040201.75129605
22Long-term depression_Homo sapiens_hsa047301.73935413
23Collecting duct acid secretion_Homo sapiens_hsa049661.72744024
24Oxytocin signaling pathway_Homo sapiens_hsa049211.72372432
25Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.60167492
26Cocaine addiction_Homo sapiens_hsa050301.51472356
27GnRH signaling pathway_Homo sapiens_hsa049121.48089490
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.40045309
29Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.32603836
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.30978336
31cAMP signaling pathway_Homo sapiens_hsa040241.30648901
32Gap junction_Homo sapiens_hsa045401.27316196
33Vitamin B6 metabolism_Homo sapiens_hsa007501.26550971
34Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.20515066
35Phosphatidylinositol signaling system_Homo sapiens_hsa040701.17944901
36Glioma_Homo sapiens_hsa052141.16521926
37Type II diabetes mellitus_Homo sapiens_hsa049301.09873062
38Estrogen signaling pathway_Homo sapiens_hsa049151.09478509
39Axon guidance_Homo sapiens_hsa043601.08302546
40Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.06806680
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.05993090
42Vibrio cholerae infection_Homo sapiens_hsa051101.04356122
43Melanogenesis_Homo sapiens_hsa049161.04207065
44ErbB signaling pathway_Homo sapiens_hsa040121.02853921
45Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01969068
46Vascular smooth muscle contraction_Homo sapiens_hsa042700.93700467
47Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.90729727
48Cardiac muscle contraction_Homo sapiens_hsa042600.90384761
49Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89558086
50Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.88896112
51Oxidative phosphorylation_Homo sapiens_hsa001900.87602241
52Pancreatic secretion_Homo sapiens_hsa049720.85719330
53Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.85656307
54Oocyte meiosis_Homo sapiens_hsa041140.81430594
55Dorso-ventral axis formation_Homo sapiens_hsa043200.81158207
56Phototransduction_Homo sapiens_hsa047440.80461159
57Phospholipase D signaling pathway_Homo sapiens_hsa040720.78006916
58Choline metabolism in cancer_Homo sapiens_hsa052310.73585636
59Thyroid hormone synthesis_Homo sapiens_hsa049180.71475949
60MAPK signaling pathway_Homo sapiens_hsa040100.70114279
61Dilated cardiomyopathy_Homo sapiens_hsa054140.66183140
62VEGF signaling pathway_Homo sapiens_hsa043700.65591671
63Parkinsons disease_Homo sapiens_hsa050120.64519369
64African trypanosomiasis_Homo sapiens_hsa051430.64074234
65Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.63658346
66Ras signaling pathway_Homo sapiens_hsa040140.62158435
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.61448153
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.58667305
69Rap1 signaling pathway_Homo sapiens_hsa040150.56662930
70Glucagon signaling pathway_Homo sapiens_hsa049220.55639037
71Sphingolipid signaling pathway_Homo sapiens_hsa040710.54864477
72Nitrogen metabolism_Homo sapiens_hsa009100.54203720
73Carbohydrate digestion and absorption_Homo sapiens_hsa049730.54105511
74Type I diabetes mellitus_Homo sapiens_hsa049400.53439513
75Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.52789833
76Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52472495
77SNARE interactions in vesicular transport_Homo sapiens_hsa041300.48646271
78Mineral absorption_Homo sapiens_hsa049780.47258576
79Inositol phosphate metabolism_Homo sapiens_hsa005620.47016231
80Alzheimers disease_Homo sapiens_hsa050100.46795517
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.46121301
82Butanoate metabolism_Homo sapiens_hsa006500.45945304
83Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45862108
84Histidine metabolism_Homo sapiens_hsa003400.45076854
85Prion diseases_Homo sapiens_hsa050200.43888040
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.43433727
87Wnt signaling pathway_Homo sapiens_hsa043100.40921232
88Rheumatoid arthritis_Homo sapiens_hsa053230.40883616
89Endocytosis_Homo sapiens_hsa041440.40580719
90Alcoholism_Homo sapiens_hsa050340.39703670
91Fatty acid biosynthesis_Homo sapiens_hsa000610.39287936
92Non-small cell lung cancer_Homo sapiens_hsa052230.38597606
93Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.38203137
94mTOR signaling pathway_Homo sapiens_hsa041500.38165958
95Circadian rhythm_Homo sapiens_hsa047100.37856721
96Ether lipid metabolism_Homo sapiens_hsa005650.36614121
97Regulation of autophagy_Homo sapiens_hsa041400.35795763
98Chemokine signaling pathway_Homo sapiens_hsa040620.35123477
99Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.34859268
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.33648796
101Ovarian steroidogenesis_Homo sapiens_hsa049130.32013492
102Renal cell carcinoma_Homo sapiens_hsa052110.31018529
103Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.30785442
104Bile secretion_Homo sapiens_hsa049760.30733564
105Arginine and proline metabolism_Homo sapiens_hsa003300.29770038
106Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.29308547
107beta-Alanine metabolism_Homo sapiens_hsa004100.29287669
108Huntingtons disease_Homo sapiens_hsa050160.29259819
109Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.27369139
110Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.26893568
111Endometrial cancer_Homo sapiens_hsa052130.26808760
112Longevity regulating pathway - mammal_Homo sapiens_hsa042110.26316316
113Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26096499
114Insulin signaling pathway_Homo sapiens_hsa049100.25808219
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.25487355
116Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.20873659
117Linoleic acid metabolism_Homo sapiens_hsa005910.20637356
118Arginine biosynthesis_Homo sapiens_hsa002200.17822132

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