CRELD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a subfamily of epidermal growth factor-related proteins. The encoded protein is characterized by a cysteine-rich with epidermal growth factor-like domain. This protein may function as a cell adhesion molecule. Mutations in this gene are the cause of atrioventricular septal defect. Alternate splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)3.87058990
2synaptic vesicle maturation (GO:0016188)3.80202848
3positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.62501325
4synaptic vesicle exocytosis (GO:0016079)3.49947076
5erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.49489778
6L-phenylalanine catabolic process (GO:0006559)3.49489778
7glutamate secretion (GO:0014047)3.46897749
8locomotory exploration behavior (GO:0035641)3.40320931
9vocalization behavior (GO:0071625)3.38933033
10L-phenylalanine metabolic process (GO:0006558)3.38541399
11erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.38541399
12cerebellar granule cell differentiation (GO:0021707)3.30391133
13neuronal action potential propagation (GO:0019227)3.29922472
14positive regulation of synapse maturation (GO:0090129)3.29307456
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.15715687
16neuronal ion channel clustering (GO:0045161)3.12488288
17positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.06207653
18proline transport (GO:0015824)3.03217113
19neurotransmitter secretion (GO:0007269)3.02894432
20regulation of synaptic vesicle exocytosis (GO:2000300)3.01140333
21gamma-aminobutyric acid transport (GO:0015812)3.00672333
22regulation of glutamate receptor signaling pathway (GO:1900449)2.99454440
23protein localization to synapse (GO:0035418)2.99106542
24regulation of ARF protein signal transduction (GO:0032012)2.95097404
25cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.89350531
26protein retention in ER lumen (GO:0006621)2.86910579
27regulation of synapse structural plasticity (GO:0051823)2.85985557
28synaptic vesicle docking involved in exocytosis (GO:0016081)2.84933738
29maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.82880319
30positive regulation of neurotransmitter secretion (GO:0001956)2.81745037
31detection of calcium ion (GO:0005513)2.78977956
32layer formation in cerebral cortex (GO:0021819)2.78446527
33activation of protein kinase A activity (GO:0034199)2.76583953
34neuromuscular process controlling posture (GO:0050884)2.76510747
35positive regulation of dendritic spine development (GO:0060999)2.75973989
36exploration behavior (GO:0035640)2.75794781
37potassium ion homeostasis (GO:0055075)2.75483941
38regulation of synaptic vesicle transport (GO:1902803)2.73770134
39membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.73595640
40positive regulation of dendritic spine morphogenesis (GO:0061003)2.73493222
41aromatic amino acid family catabolic process (GO:0009074)2.72614863
42alpha-linolenic acid metabolic process (GO:0036109)2.71507200
43regulation of neuronal synaptic plasticity (GO:0048168)2.71487048
44creatine metabolic process (GO:0006600)2.70445665
45neuron cell-cell adhesion (GO:0007158)2.70265890
46cell communication by electrical coupling (GO:0010644)2.69624084
47dendritic spine organization (GO:0097061)2.67841465
48dicarboxylic acid biosynthetic process (GO:0043650)2.66414817
49positive regulation of triglyceride lipase activity (GO:0061365)2.65059271
50positive regulation of lipoprotein lipase activity (GO:0051006)2.65059271
51alanine transport (GO:0032328)2.64690466
52neurotransmitter-gated ion channel clustering (GO:0072578)2.63593967
53triglyceride-rich lipoprotein particle remodeling (GO:0034370)2.63456558
54glutamate metabolic process (GO:0006536)2.62649862
55regulation of synapse maturation (GO:0090128)2.60923017
56central nervous system myelination (GO:0022010)2.60808009
57axon ensheathment in central nervous system (GO:0032291)2.60808009
58positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.59947734
59bile acid biosynthetic process (GO:0006699)2.58887018
60coenzyme catabolic process (GO:0009109)2.58544240
61detection of temperature stimulus involved in sensory perception of pain (GO:0050965)2.57403688
62detection of temperature stimulus involved in sensory perception (GO:0050961)2.57403688
63positive regulation of neurotransmitter transport (GO:0051590)2.57024887
64negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.56468679
65cellular sodium ion homeostasis (GO:0006883)2.55667700
66pyrimidine nucleobase catabolic process (GO:0006208)2.54520139
67establishment of mitochondrion localization (GO:0051654)2.54084694
68cellular ketone body metabolic process (GO:0046950)2.53791114
69regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.53677112
70positive regulation of membrane potential (GO:0045838)2.52499542
71cell migration in hindbrain (GO:0021535)2.52351192
72membrane depolarization during action potential (GO:0086010)2.51939391
73regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.50447604
74cell communication involved in cardiac conduction (GO:0086065)2.49853544
75cellular potassium ion homeostasis (GO:0030007)2.49366490
76potassium ion import (GO:0010107)2.49125676
77regulation of long-term neuronal synaptic plasticity (GO:0048169)2.48964627
78regulation of cholesterol homeostasis (GO:2000188)2.48425010
79regulation of synaptic plasticity (GO:0048167)2.46611330
80synaptic vesicle endocytosis (GO:0048488)2.46411172
81positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.46336426
82response to gravity (GO:0009629)2.44525872
83cytoskeletal anchoring at plasma membrane (GO:0007016)2.44166699
84negative regulation of synaptic transmission, GABAergic (GO:0032229)2.44129790
85sodium ion export (GO:0071436)2.43931881
86regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.43794071
87kynurenine metabolic process (GO:0070189)2.43660547
88dicarboxylic acid catabolic process (GO:0043649)2.43471080
89regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.43378544
90amino acid import (GO:0043090)2.42082086
91ionotropic glutamate receptor signaling pathway (GO:0035235)2.41535294
92positive regulation of synaptic transmission, GABAergic (GO:0032230)2.39750108
93regulation of neurotransmitter secretion (GO:0046928)2.39112643
94regulation of voltage-gated calcium channel activity (GO:1901385)2.38247437
95neurotransmitter transport (GO:0006836)2.38056344
96lysine catabolic process (GO:0006554)2.36452994
97lysine metabolic process (GO:0006553)2.36452994
98regulation of neurotransmitter levels (GO:0001505)2.35981631
99regulation of cholesterol biosynthetic process (GO:0045540)2.35962244
100high-density lipoprotein particle remodeling (GO:0034375)2.35958743
101L-amino acid import (GO:0043092)2.35735205
102glyoxylate metabolic process (GO:0046487)2.35696538
103detection of temperature stimulus (GO:0016048)2.34897389
104neuromuscular process controlling balance (GO:0050885)2.34048874
105mating behavior (GO:0007617)2.33493116
106glycine transport (GO:0015816)2.32967887
107negative regulation of fibrinolysis (GO:0051918)2.32414061
108postsynaptic membrane organization (GO:0001941)2.31051368
109positive regulation of dendrite development (GO:1900006)2.30856136
110acetyl-CoA metabolic process (GO:0006084)2.30841923
111aspartate family amino acid catabolic process (GO:0009068)2.30831289
112positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.30601042
113nucleobase catabolic process (GO:0046113)2.28483961
114regulation of protein activation cascade (GO:2000257)2.27995902
115regulation of excitatory postsynaptic membrane potential (GO:0060079)2.27628540
116complement activation, alternative pathway (GO:0006957)2.26338378
117dicarboxylic acid transport (GO:0006835)2.25860045
118establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.25570603
119mitochondrion transport along microtubule (GO:0047497)2.25570603
120auditory behavior (GO:0031223)2.24599744
121regulation of cholesterol metabolic process (GO:0090181)2.23592490
122sulfur amino acid catabolic process (GO:0000098)2.23177070
123ketone body metabolic process (GO:1902224)2.22567756
124negative regulation of dendrite morphogenesis (GO:0050774)2.22108988
125long-term memory (GO:0007616)2.20832395
1262-oxoglutarate metabolic process (GO:0006103)2.20513541
127innervation (GO:0060384)2.20441439
128regulation of cholesterol esterification (GO:0010872)2.20280260
129regulation of female receptivity (GO:0045924)2.19857693
130synaptic transmission, glutamatergic (GO:0035249)2.19783644
131retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.19748619
132cerebellar Purkinje cell differentiation (GO:0021702)2.19604837
133regulation of dendritic spine morphogenesis (GO:0061001)2.18238435
134glutamate receptor signaling pathway (GO:0007215)2.18145975
135neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.18099761
136fatty acid transmembrane transport (GO:1902001)2.17756378
137regulation of complement activation (GO:0030449)2.17738896
138regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.17427977
139regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.17297216
140peptidyl-glutamic acid carboxylation (GO:0017187)2.17277417
141protein carboxylation (GO:0018214)2.17277417
142neuron-neuron synaptic transmission (GO:0007270)2.16947381
143dendritic spine morphogenesis (GO:0060997)2.16808022
144regulation of postsynaptic membrane potential (GO:0060078)2.16477374
145short-chain fatty acid metabolic process (GO:0046459)2.16430696
146regulation of vesicle fusion (GO:0031338)2.16419064
147cerebellar Purkinje cell layer development (GO:0021680)2.16210917

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human4.02097886
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.46063019
3SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.65075179
4SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.60649591
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.48476727
6RXR_22158963_ChIP-Seq_LIVER_Mouse2.46978683
7EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37783975
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37783975
9JARID2_20075857_ChIP-Seq_MESCs_Mouse2.31033388
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.29345886
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.29190926
12MTF2_20144788_ChIP-Seq_MESCs_Mouse2.28048393
13SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.25749407
14GBX2_23144817_ChIP-Seq_PC3_Human2.24570418
15SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.16413475
16SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11991465
17MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.11201167
18SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10759481
19* RARB_27405468_Chip-Seq_BRAIN_Mouse2.07163259
20REST_21632747_ChIP-Seq_MESCs_Mouse2.07042218
21FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.00609278
22DROSHA_22980978_ChIP-Seq_HELA_Human1.96962968
23ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.96364584
24LXR_22158963_ChIP-Seq_LIVER_Mouse1.95894772
25SUZ12_27294783_Chip-Seq_ESCs_Mouse1.95761989
26EZH2_27294783_Chip-Seq_ESCs_Mouse1.95354342
27EZH2_27304074_Chip-Seq_ESCs_Mouse1.90867156
28* PPARA_22158963_ChIP-Seq_LIVER_Mouse1.89350882
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.88896747
30ERG_21242973_ChIP-ChIP_JURKAT_Human1.87943080
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.83571862
32NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.79103621
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.76172576
34THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.68694388
35RNF2_27304074_Chip-Seq_ESCs_Mouse1.63913196
36EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62891039
37SRY_22984422_ChIP-ChIP_TESTIS_Rat1.48169829
38PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.47714136
39DNAJC2_21179169_ChIP-ChIP_NT2_Human1.46067058
40CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.41654982
41NR3C1_23031785_ChIP-Seq_PC12_Mouse1.38923752
42TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37368030
43IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34099532
44SMC4_20622854_ChIP-Seq_HELA_Human1.33816827
45AR_21572438_ChIP-Seq_LNCaP_Human1.27797797
46P68_20966046_ChIP-Seq_HELA_Human1.27411875
47PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.24977041
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.23218758
49CTCF_27219007_Chip-Seq_Bcells_Human1.23094654
50ZFP281_18757296_ChIP-ChIP_E14_Mouse1.22091521
51GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.20609208
52TAF15_26573619_Chip-Seq_HEK293_Human1.18980838
53EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.17662972
54* KDM2B_26808549_Chip-Seq_K562_Human1.17324247
55* TET1_21451524_ChIP-Seq_MESCs_Mouse1.16011385
56KDM2B_26808549_Chip-Seq_DND41_Human1.15812744
57RACK7_27058665_Chip-Seq_MCF-7_Human1.15632155
58SA1_27219007_Chip-Seq_ERYTHROID_Human1.15146434
59UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.13916889
60CTBP2_25329375_ChIP-Seq_LNCAP_Human1.12625182
61RING1B_27294783_Chip-Seq_ESCs_Mouse1.09619025
62PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.08483775
63CREB1_26743006_Chip-Seq_LNCaP_Human1.08096208
64SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.08029900
65LXR_22292898_ChIP-Seq_THP-1_Human1.06741978
66ZNF274_21170338_ChIP-Seq_K562_Hela1.06486982
67WT1_25993318_ChIP-Seq_PODOCYTE_Human1.06029442
68ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.05588836
69RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.05134756
70ELK3_25401928_ChIP-Seq_HUVEC_Human1.04843927
71CTCF_27219007_Chip-Seq_ERYTHROID_Human1.04468890
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.04396838
73* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.04345190
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.03543790
75GATA1_19941826_ChIP-Seq_K562_Human1.03421893
76SOX2_21211035_ChIP-Seq_LN229_Gbm1.03341735
77GATA1_19941827_ChIP-Seq_MEL_Mouse1.03303992
78CDX2_19796622_ChIP-Seq_MESCs_Mouse1.02943644
79SMAD4_21799915_ChIP-Seq_A2780_Human1.02283913
80WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02218840
81PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.01278743
82CTBP1_25329375_ChIP-Seq_LNCAP_Human0.99976728
83EP300_21415370_ChIP-Seq_HL-1_Mouse0.99764837
84RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99352341
85ESR1_20079471_ChIP-ChIP_T-47D_Human0.98567183
86RAD21_21589869_ChIP-Seq_MESCs_Mouse0.98256809
87NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.97555399
88* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.96487487
89BCL6_27268052_Chip-Seq_Bcells_Human0.95468974
90CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.95361917
91NFIB_24661679_ChIP-Seq_LUNG_Mouse0.95200253
92* BCOR_27268052_Chip-Seq_Bcells_Human0.94557660
93EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.93587718
94OCT4_19829295_ChIP-Seq_ESCs_Human0.93576434
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.93270457
96KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.93123412
97TRIM28_21343339_ChIP-Seq_HEK293_Human0.92983488
98AR_19668381_ChIP-Seq_PC3_Human0.92913429
99CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.92395965
100SMAD4_21741376_ChIP-Seq_HESCs_Human0.92265636
101ELF1_20517297_ChIP-Seq_JURKAT_Human0.92220095
102TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.91888905
103TET1_21490601_ChIP-Seq_MESCs_Mouse0.91203351
104TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90823889
105SA1_27219007_Chip-Seq_Bcells_Human0.89742753
106PIAS1_25552417_ChIP-Seq_VCAP_Human0.88861719
107AHR_22903824_ChIP-Seq_MCF-7_Human0.88797948
108TP53_20018659_ChIP-ChIP_R1E_Mouse0.88002323
109GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.87464231
110ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.86685971
111AR_25329375_ChIP-Seq_VCAP_Human0.85856903
112SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.85485195
113FOXA2_19822575_ChIP-Seq_HepG2_Human0.85264563
114* TP53_23651856_ChIP-Seq_MEFs_Mouse0.85005416
115CTCF_20526341_ChIP-Seq_ESCs_Human0.83940106
116ZNF263_19887448_ChIP-Seq_K562_Human0.83807944
117* OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.83281778
118TCF7L2_21901280_ChIP-Seq_H4IIE_Rat0.83027637
119* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.82666842
120SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.82577645
121SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.81262465
122ZNF217_24962896_ChIP-Seq_MCF-7_Human0.81219179
123RING1B_27294783_Chip-Seq_NPCs_Mouse0.80871066
124KDM2B_26808549_Chip-Seq_SUP-B15_Human0.79216676
125KLF4_19829295_ChIP-Seq_ESCs_Human0.78998506
126RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.78812294
127RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.76926458
128MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.76220002
129ARNT_22903824_ChIP-Seq_MCF-7_Human0.75434791
130BCAT_22108803_ChIP-Seq_LS180_Human0.75042523
131CLOCK_20551151_ChIP-Seq_293T_Human0.74985131
132EGR1_23403033_ChIP-Seq_LIVER_Mouse0.74654581
133TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.74405223

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.25312028
2MP0004270_analgesia3.18282673
3MP0002139_abnormal_hepatobiliary_system3.09518605
4MP0003880_abnormal_central_pattern2.91482183
5MP0003635_abnormal_synaptic_transmissio2.81794036
6MP0003122_maternal_imprinting2.72899452
7MP0001968_abnormal_touch/_nociception2.70865487
8MP0002837_dystrophic_cardiac_calcinosis2.64270080
9MP0005360_urolithiasis2.61846744
10MP0005085_abnormal_gallbladder_physiolo2.48549444
11MP0002735_abnormal_chemical_nociception2.45195203
12MP0002822_catalepsy2.38261604
13MP0009745_abnormal_behavioral_response2.30306922
14MP0002736_abnormal_nociception_after2.28048113
15MP0004858_abnormal_nervous_system2.20614441
16MP0002064_seizures2.20095453
17MP0003329_amyloid_beta_deposits2.18946510
18MP0002063_abnormal_learning/memory/cond2.18551833
19MP0005058_abnormal_lysosome_morphology2.17046382
20MP0005365_abnormal_bile_salt2.15705575
21MP0002734_abnormal_mechanical_nocicepti2.12742729
22MP0006276_abnormal_autonomic_nervous2.10389438
23MP0009046_muscle_twitch2.07606634
24MP0000751_myopathy2.05820355
25MP0002733_abnormal_thermal_nociception1.96884841
26MP0005083_abnormal_biliary_tract1.94147970
27MP0008875_abnormal_xenobiotic_pharmacok1.92023178
28MP0002272_abnormal_nervous_system1.89967239
29MP0003172_abnormal_lysosome_physiology1.83377723
30MP0002572_abnormal_emotion/affect_behav1.80740544
31MP0010329_abnormal_lipoprotein_level1.74925616
32MP0002909_abnormal_adrenal_gland1.72166295
33MP0009780_abnormal_chondrocyte_physiolo1.69480989
34MP0004130_abnormal_muscle_cell1.68596657
35MP0001970_abnormal_pain_threshold1.67335790
36MP0003123_paternal_imprinting1.67190178
37MP0001501_abnormal_sleep_pattern1.66510622
38MP0005167_abnormal_blood-brain_barrier1.62004631
39MP0001440_abnormal_grooming_behavior1.60221272
40MP0002638_abnormal_pupillary_reflex1.59554443
41MP0001486_abnormal_startle_reflex1.55518876
42MP0002067_abnormal_sensory_capabilities1.44332862
43MP0000604_amyloidosis1.40666949
44MP0009840_abnormal_foam_cell1.33081271
45MP0002184_abnormal_innervation1.30338546
46MP0000747_muscle_weakness1.29833397
47MP0005332_abnormal_amino_acid1.28840659
48MP0005535_abnormal_body_temperature1.28270574
49MP0000749_muscle_degeneration1.27410167
50MP0005423_abnormal_somatic_nervous1.24997869
51MP0003195_calcinosis1.23109427
52MP0002118_abnormal_lipid_homeostasis1.23096548
53MP0000955_abnormal_spinal_cord1.22658402
54MP0004145_abnormal_muscle_electrophysio1.22542336
55MP0004036_abnormal_muscle_relaxation1.21794862
56MP0000013_abnormal_adipose_tissue1.20651608
57MP0004811_abnormal_neuron_physiology1.19398571
58MP0003646_muscle_fatigue1.18570374
59MP0005386_behavior/neurological_phenoty1.17419507
60MP0004924_abnormal_behavior1.17419507
61MP0003633_abnormal_nervous_system1.14142086
62MP0008569_lethality_at_weaning1.13203035
63MP0003252_abnormal_bile_duct1.10300737
64MP0008874_decreased_physiological_sensi1.08928759
65MP0003879_abnormal_hair_cell1.07995497
66MP0002066_abnormal_motor_capabilities/c1.07661263
67MP0004142_abnormal_muscle_tone1.07294322
68MP0005451_abnormal_body_composition1.06689603
69MP0003690_abnormal_glial_cell1.04188716
70MP0002557_abnormal_social/conspecific_i1.03812709
71MP0010386_abnormal_urinary_bladder1.03214599
72MP0001502_abnormal_circadian_rhythm1.02376291
73MP0004085_abnormal_heartbeat1.02030215
74MP0002269_muscular_atrophy0.99750394
75MP0005584_abnormal_enzyme/coenzyme_acti0.99611890
76MP0003806_abnormal_nucleotide_metabolis0.99341080
77MP0005620_abnormal_muscle_contractility0.96959952
78MP0000778_abnormal_nervous_system0.94864686
79MP0008961_abnormal_basal_metabolism0.94850029
80MP0002882_abnormal_neuron_morphology0.94350512
81MP0003137_abnormal_impulse_conducting0.93769191
82MP0002090_abnormal_vision0.93202039
83MP0003631_nervous_system_phenotype0.92572742
84MP0000681_abnormal_thyroid_gland0.92261116
85MP0002971_abnormal_brown_adipose0.92123681
86MP0004215_abnormal_myocardial_fiber0.91803971
87MP0001984_abnormal_olfaction0.91796751
88MP0003279_aneurysm0.91200740
89MP0008260_abnormal_autophagy0.90820777
90MP0002653_abnormal_ependyma_morphology0.90446327
91MP0003075_altered_response_to0.89385982
92MP0003191_abnormal_cellular_cholesterol0.89305842
93MP0005670_abnormal_white_adipose0.89264417
94MP0002876_abnormal_thyroid_physiology0.89148925
95MP0004084_abnormal_cardiac_muscle0.89066374
96MP0001529_abnormal_vocalization0.87610570
97MP0005330_cardiomyopathy0.86070441
98MP0002295_abnormal_pulmonary_circulatio0.85901447
99MP0004885_abnormal_endolymph0.84918383
100MP0002229_neurodegeneration0.84211897
101MP0008438_abnormal_cutaneous_collagen0.83733698
102MP0002069_abnormal_eating/drinking_beha0.83056622
103MP0002078_abnormal_glucose_homeostasis0.81812191
104MP0003634_abnormal_glial_cell0.81232197
105MP0004087_abnormal_muscle_fiber0.80931315
106MP0002972_abnormal_cardiac_muscle0.80739487
107MP0000678_abnormal_parathyroid_gland0.79878242
108MP0000003_abnormal_adipose_tissue0.79177487
109MP0004233_abnormal_muscle_weight0.78673917
110MP0010368_abnormal_lymphatic_system0.78561574
111MP0005646_abnormal_pituitary_gland0.77979305
112MP0001905_abnormal_dopamine_level0.77961644
113MP0000920_abnormal_myelination0.76990388
114MP0003283_abnormal_digestive_organ0.76356721
115MP0004510_myositis0.75384221
116MP0000759_abnormal_skeletal_muscle0.74666639
117MP0000230_abnormal_systemic_arterial0.72192459
118MP0005448_abnormal_energy_balance0.72117263
119MP0004742_abnormal_vestibular_system0.71863732
120MP0008872_abnormal_physiological_respon0.70527218
121MP0003632_abnormal_nervous_system0.69901993
122MP0001963_abnormal_hearing_physiology0.69497487
123MP0005409_darkened_coat_color0.68703005
124MP0001958_emphysema0.67099815

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)5.24925993
2Focal motor seizures (HP:0011153)4.16146519
3Focal seizures (HP:0007359)3.50744124
4Abnormality of aromatic amino acid family metabolism (HP:0004338)3.46592365
5Deep venous thrombosis (HP:0002625)3.36680059
6Abnormality of binocular vision (HP:0011514)3.36091557
7Diplopia (HP:0000651)3.36091557
8Visual hallucinations (HP:0002367)3.21063936
9Pheochromocytoma (HP:0002666)3.06197160
10Action tremor (HP:0002345)3.03486012
11Supranuclear gaze palsy (HP:0000605)3.00825015
12Xanthomatosis (HP:0000991)2.97579450
13Atonic seizures (HP:0010819)2.96324049
14Neurofibrillary tangles (HP:0002185)2.86468217
15Hyperlipoproteinemia (HP:0010980)2.83327541
16Polyphagia (HP:0002591)2.80850951
17Exercise-induced myalgia (HP:0003738)2.77615772
18Peripheral hypomyelination (HP:0007182)2.74844962
19Abnormality of the lower motor neuron (HP:0002366)2.73650341
20Cerebral inclusion bodies (HP:0100314)2.70592407
21Ketosis (HP:0001946)2.70049392
22Generalized tonic-clonic seizures (HP:0002069)2.66200522
23Absence seizures (HP:0002121)2.60341052
24Neuroendocrine neoplasm (HP:0100634)2.60238423
25Intrahepatic cholestasis (HP:0001406)2.55889934
26Complement deficiency (HP:0004431)2.55610542
27Hyperthyroidism (HP:0000836)2.55483325
28Cholecystitis (HP:0001082)2.54572873
29Abnormal gallbladder physiology (HP:0012438)2.54572873
30Ankle clonus (HP:0011448)2.50116205
31Ketoacidosis (HP:0001993)2.49477665
32Progressive cerebellar ataxia (HP:0002073)2.47545321
33Torticollis (HP:0000473)2.45891142
34Epileptic encephalopathy (HP:0200134)2.45657687
35Akinesia (HP:0002304)2.43564942
36Dialeptic seizures (HP:0011146)2.40687975
37Mutism (HP:0002300)2.39978707
38Papilledema (HP:0001085)2.37768002
39Sudden death (HP:0001699)2.37003380
40Anxiety (HP:0000739)2.36905706
41Growth hormone excess (HP:0000845)2.35403540
42Febrile seizures (HP:0002373)2.35087575
43Impaired social interactions (HP:0000735)2.33305953
44Abnormal social behavior (HP:0012433)2.33305953
45Status epilepticus (HP:0002133)2.32254648
46Myotonia (HP:0002486)2.31861720
47Hyperventilation (HP:0002883)2.30570948
48Clonus (HP:0002169)2.30462535
49Abnormality of monocarboxylic acid metabolism (HP:0010996)2.30210618
50Impaired vibration sensation in the lower limbs (HP:0002166)2.28943374
51Joint hemorrhage (HP:0005261)2.28861642
52Depression (HP:0000716)2.28228021
53Hyperammonemia (HP:0001987)2.27679727
54Neuronal loss in central nervous system (HP:0002529)2.25949232
55Termporal pattern (HP:0011008)2.25440161
56Insidious onset (HP:0003587)2.25440161
57Hyporeflexia of lower limbs (HP:0002600)2.23954794
58Neonatal onset (HP:0003623)2.23756518
59Myoglobinuria (HP:0002913)2.22487357
60Heart block (HP:0012722)2.22276824
61Focal dystonia (HP:0004373)2.21340204
62Truncal ataxia (HP:0002078)2.20595440
63Craniofacial dystonia (HP:0012179)2.20575781
64Truncus arteriosus (HP:0001660)2.20447221
65Dysdiadochokinesis (HP:0002075)2.19125793
66Impaired pain sensation (HP:0007328)2.18869223
67Abnormality of pain sensation (HP:0010832)2.18869223
68Poor eye contact (HP:0000817)2.18530474
69Obstructive sleep apnea (HP:0002870)2.18411883
70Upper limb amyotrophy (HP:0009129)2.18150051
71Distal upper limb amyotrophy (HP:0007149)2.18150051
72Prolonged partial thromboplastin time (HP:0003645)2.17785501
73Abnormal atrioventricular conduction (HP:0005150)2.16913054
74Urinary urgency (HP:0000012)2.14266905
75Dysostosis multiplex (HP:0000943)2.13997266
76Reticulocytosis (HP:0001923)2.13863039
77Skin nodule (HP:0200036)2.13781695
78Hemiplegia (HP:0002301)2.13696755
79Abnormal eating behavior (HP:0100738)2.11254785
80Abnormality of mucopolysaccharide metabolism (HP:0011020)2.10903576
81Abnormality of polysaccharide metabolism (HP:0011012)2.10903576
82Abnormality of glycosaminoglycan metabolism (HP:0004371)2.10903576
83Dysmetria (HP:0001310)2.10168051
84Mucopolysacchariduria (HP:0008155)2.09510456
85Urinary glycosaminoglycan excretion (HP:0003541)2.09510456
86Abnormality of the periventricular white matter (HP:0002518)2.09370797
87Postural instability (HP:0002172)2.09350274
88Cholelithiasis (HP:0001081)2.08900571
89Rapidly progressive (HP:0003678)2.08519092
90Hand muscle atrophy (HP:0009130)2.08045303
91Cerebral aneurysm (HP:0004944)2.05873773
92Abnormal gallbladder morphology (HP:0012437)2.03930951
93Cerebral hemorrhage (HP:0001342)2.03513740
94Axonal loss (HP:0003447)2.02213413
95Hyperglycinemia (HP:0002154)2.01634190
96Hemiparesis (HP:0001269)2.01530112
97Difficulty running (HP:0009046)1.99220143
98Gout (HP:0001997)1.98350427
99Hypobetalipoproteinemia (HP:0003563)1.97812450
100Sensorimotor neuropathy (HP:0007141)1.97691338
101Urinary bladder sphincter dysfunction (HP:0002839)1.97152359
102Spastic gait (HP:0002064)1.96133367
103Oligomenorrhea (HP:0000876)1.95334670
104Hammertoe (HP:0001765)1.93948510
105Abnormality of the corticospinal tract (HP:0002492)1.93821612
106Epidermoid cyst (HP:0200040)1.93434555
107Annular pancreas (HP:0001734)1.92870662
108Abnormality of the Achilles tendon (HP:0005109)1.92535447
109Hypercortisolism (HP:0001578)1.92531432
110Atrioventricular block (HP:0001678)1.90953905
111Hypoalphalipoproteinemia (HP:0003233)1.90919555
112Tetraplegia (HP:0002445)1.90205754
113Syncope (HP:0001279)1.88927654
114Abnormal EKG (HP:0003115)1.88765352
115Amblyopia (HP:0000646)1.88735625
116Scanning speech (HP:0002168)1.87875191
117Prolonged QT interval (HP:0001657)1.87799804
118Exercise-induced muscle cramps (HP:0003710)1.86189187
119Muscle hypertrophy of the lower extremities (HP:0008968)1.86162343
120Delusions (HP:0000746)1.85550684
121Epileptiform EEG discharges (HP:0011182)1.84819808
122Ventricular fibrillation (HP:0001663)1.84459088
123Abnormality of serine family amino acid metabolism (HP:0010894)1.84296461
124Abnormality of glycine metabolism (HP:0010895)1.84296461
125Systemic lupus erythematosus (HP:0002725)1.84200475
126Rigidity (HP:0002063)1.83374952
127EEG with generalized epileptiform discharges (HP:0011198)1.83237223
128J-shaped sella turcica (HP:0002680)1.82522452
129Myopathic facies (HP:0002058)1.82177273
130Hemorrhage of the eye (HP:0011885)1.81950558
131Calf muscle hypertrophy (HP:0008981)1.81472693
132Hyperglycinuria (HP:0003108)1.80737927
133Hypsarrhythmia (HP:0002521)1.79472020
134Bundle branch block (HP:0011710)1.78359873
135Bradykinesia (HP:0002067)1.78065635
136Lower limb muscle weakness (HP:0007340)1.77591237
137Foot dorsiflexor weakness (HP:0009027)1.77282395
138Sleep apnea (HP:0010535)1.77031925
139Dysmetric saccades (HP:0000641)1.76173273
140EMG: myopathic abnormalities (HP:0003458)1.75660882
141Hypolipoproteinemia (HP:0010981)1.75558207
142Increased variability in muscle fiber diameter (HP:0003557)1.73688342
143Slow progression (HP:0003677)1.72885566
144Muscle stiffness (HP:0003552)1.72773467
145Nuclear cataract (HP:0100018)1.71729954
146Agitation (HP:0000713)1.71136810
147Degeneration of the lateral corticospinal tracts (HP:0002314)1.71035320
148Mitral stenosis (HP:0001718)1.70969366
149Intention tremor (HP:0002080)1.70746711
150Abnormality of glutamine family amino acid metabolism (HP:0010902)1.70468078

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.37289768
2EPHA43.21355853
3MAP3K93.15477726
4NTRK12.66367730
5DAPK22.56260580
6KSR22.51931630
7MINK12.31938622
8MAP2K42.06096913
9PHKG22.03872591
10PHKG12.03872591
11MAP3K41.98126226
12MARK11.96736939
13PAK61.94408347
14TRIB31.83983593
15PINK11.79231576
16GRK51.77844710
17ARAF1.59886441
18TESK11.59421345
19BCKDK1.57419430
20LMTK21.51054099
21MAP3K121.42966970
22PRKD31.39405780
23NTRK21.39066797
24CAMKK11.35197689
25MAP3K21.29930356
26CDK51.25883159
27RET1.25859691
28MAP2K71.19940958
29PAK31.17924748
30LATS21.17680653
31KSR11.17446146
32CASK1.09296196
33DAPK11.07006940
34PRKD21.06899020
35SIK11.04190368
36ERN11.03742944
37RIPK41.03630009
38MAP3K111.01271050
39TNK21.00906077
40PRKCG0.99714458
41MAP2K10.97845614
42UHMK10.97805098
43MAP3K10.97118831
44SIK20.96327380
45MAP2K60.96177401
46CAMK2A0.94794347
47MAP4K20.93934000
48MAP3K130.91106534
49PTK2B0.89522756
50PRKCH0.89333732
51PKN20.88854012
52TYRO30.87395227
53SGK2230.87216386
54SGK4940.87216386
55PIM20.85756276
56PDPK10.83563621
57LIMK10.83254022
58DYRK1B0.82660419
59STK380.81703980
60EPHA30.81387869
61PRPF4B0.79520350
62TESK20.78467671
63ICK0.78449585
64CDK140.76694561
65FER0.75524520
66CAMK2G0.74857198
67RAF10.74556329
68MAP3K70.74050029
69BMX0.73100004
70DDR20.71502520
71PDGFRA0.70614780
72DAPK30.69014629
73PRKCZ0.69014373
74CAMK2B0.68452767
75CAMKK20.68180167
76MAPK120.67484034
77CDK180.67371999
78CDK150.66996820
79TBK10.66973283
80PDK10.66507767
81PLK20.66329237
82NEK10.65176738
83TAOK10.64971088
84WNK40.64782977
85PKN10.63952158
86OBSCN0.63902661
87EPHB10.63873364
88DYRK1A0.63710604
89MAPK130.63668715
90CAMK2D0.61868452
91CAMK10.61437557
92MARK20.61188291
93MAPK150.61005151
94RIPK10.60968623
95CDC42BPA0.60908419
96MAPKAPK30.60665330
97RPS6KA20.59390295
98STK110.57190780
99PTK20.56808455
100PRKAA10.55935995
101INSRR0.55677810
102FES0.55607911
103CDK11A0.54078663
104PDK30.53899093
105PDK40.53899093
106PRKCE0.53772601
107EPHB20.53449943
108CDK190.53044493
109SGK30.52959291
110CSNK1G20.52776420
111MAP3K60.51257616
112FGFR40.51051338
113TAOK30.50253066
114ERBB40.47635523
115TTN0.47363429
116PRKACG0.47136995
117WNK10.46945760
118MAPK70.45226666
119OXSR10.44660913
120MUSK0.44507908
121CAMK1D0.44488069
122CAMK40.44353728
123MYLK0.44041519
124PRKD10.43445179
125SGK10.42956132

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.95843649
2Nitrogen metabolism_Homo sapiens_hsa009102.75265051
3Primary bile acid biosynthesis_Homo sapiens_hsa001202.39708413
4Synaptic vesicle cycle_Homo sapiens_hsa047212.20087058
5Arginine biosynthesis_Homo sapiens_hsa002202.17489669
6Nicotine addiction_Homo sapiens_hsa050331.79536273
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.79179060
8Butanoate metabolism_Homo sapiens_hsa006501.76743107
9Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.70487275
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.68861128
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.68483639
12GABAergic synapse_Homo sapiens_hsa047271.65398750
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.62302407
14Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.54320902
15Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.49579780
16Glycosaminoglycan degradation_Homo sapiens_hsa005311.48811585
17Fatty acid degradation_Homo sapiens_hsa000711.47772004
18Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.47523719
19Circadian entrainment_Homo sapiens_hsa047131.44868171
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.41414280
21Propanoate metabolism_Homo sapiens_hsa006401.40591949
22Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.40559301
23Other glycan degradation_Homo sapiens_hsa005111.40510467
24Olfactory transduction_Homo sapiens_hsa047401.40287624
25Bile secretion_Homo sapiens_hsa049761.37848856
26Fatty acid metabolism_Homo sapiens_hsa012121.34999070
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.34884572
28Tryptophan metabolism_Homo sapiens_hsa003801.34139011
29Insulin secretion_Homo sapiens_hsa049111.30863040
30PPAR signaling pathway_Homo sapiens_hsa033201.30695315
31Morphine addiction_Homo sapiens_hsa050321.29531990
32Glutamatergic synapse_Homo sapiens_hsa047241.29500457
33Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28611278
34Long-term potentiation_Homo sapiens_hsa047201.20629939
35Pyruvate metabolism_Homo sapiens_hsa006201.19372752
36Dopaminergic synapse_Homo sapiens_hsa047281.18018883
37Amphetamine addiction_Homo sapiens_hsa050311.17979884
38Salivary secretion_Homo sapiens_hsa049701.15536593
39Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.15191606
40Cardiac muscle contraction_Homo sapiens_hsa042601.14065053
41Complement and coagulation cascades_Homo sapiens_hsa046101.13921142
42Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.13009328
43Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.07130837
44Fructose and mannose metabolism_Homo sapiens_hsa000511.05782332
45Aldosterone synthesis and secretion_Homo sapiens_hsa049251.04633861
46Phenylalanine metabolism_Homo sapiens_hsa003601.04130057
47Cholinergic synapse_Homo sapiens_hsa047251.02524683
48Taste transduction_Homo sapiens_hsa047420.97254755
49Renin secretion_Homo sapiens_hsa049240.95822155
50Collecting duct acid secretion_Homo sapiens_hsa049660.94259837
51Cocaine addiction_Homo sapiens_hsa050300.94212113
52Peroxisome_Homo sapiens_hsa041460.94008406
53Gastric acid secretion_Homo sapiens_hsa049710.93241829
54Carbon metabolism_Homo sapiens_hsa012000.88497079
55Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.88319014
56Fatty acid elongation_Homo sapiens_hsa000620.86815034
57Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.84386483
58Oxytocin signaling pathway_Homo sapiens_hsa049210.84066039
59Tyrosine metabolism_Homo sapiens_hsa003500.83388787
60Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83147233
61Calcium signaling pathway_Homo sapiens_hsa040200.82018566
62Prion diseases_Homo sapiens_hsa050200.81565594
63beta-Alanine metabolism_Homo sapiens_hsa004100.81328254
64Serotonergic synapse_Homo sapiens_hsa047260.78204351
65Phosphatidylinositol signaling system_Homo sapiens_hsa040700.75776595
66SNARE interactions in vesicular transport_Homo sapiens_hsa041300.75303154
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.74224463
68Biosynthesis of amino acids_Homo sapiens_hsa012300.73691550
69Long-term depression_Homo sapiens_hsa047300.73386156
70Glucagon signaling pathway_Homo sapiens_hsa049220.73045780
71Dilated cardiomyopathy_Homo sapiens_hsa054140.72449989
72GnRH signaling pathway_Homo sapiens_hsa049120.72274358
73Lysosome_Homo sapiens_hsa041420.71765519
74Type II diabetes mellitus_Homo sapiens_hsa049300.70958868
75Oxidative phosphorylation_Homo sapiens_hsa001900.70001218
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.68764143
77Gap junction_Homo sapiens_hsa045400.68560567
78Fatty acid biosynthesis_Homo sapiens_hsa000610.68055596
79AMPK signaling pathway_Homo sapiens_hsa041520.67562545
80Starch and sucrose metabolism_Homo sapiens_hsa005000.65969951
81Glycerolipid metabolism_Homo sapiens_hsa005610.63828012
82Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.63586071
83Histidine metabolism_Homo sapiens_hsa003400.63570953
84Alzheimers disease_Homo sapiens_hsa050100.63129531
85Vibrio cholerae infection_Homo sapiens_hsa051100.62651262
86Carbohydrate digestion and absorption_Homo sapiens_hsa049730.62163795
87Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.61633864
88Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60453146
89Parkinsons disease_Homo sapiens_hsa050120.59217369
90Pancreatic secretion_Homo sapiens_hsa049720.58565007
91VEGF signaling pathway_Homo sapiens_hsa043700.58251607
92Sulfur metabolism_Homo sapiens_hsa009200.57966801
93Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.57892025
94Vitamin B6 metabolism_Homo sapiens_hsa007500.57777870
95Galactose metabolism_Homo sapiens_hsa000520.57031602
96cAMP signaling pathway_Homo sapiens_hsa040240.56489704
97Maturity onset diabetes of the young_Homo sapiens_hsa049500.54856867
98Endocytosis_Homo sapiens_hsa041440.54437417
99Estrogen signaling pathway_Homo sapiens_hsa049150.54177924
100Vascular smooth muscle contraction_Homo sapiens_hsa042700.52820196
101Insulin signaling pathway_Homo sapiens_hsa049100.51102604
102Chemical carcinogenesis_Homo sapiens_hsa052040.50630936
103Glycerophospholipid metabolism_Homo sapiens_hsa005640.50370984
104Thyroid hormone synthesis_Homo sapiens_hsa049180.49659568
105Axon guidance_Homo sapiens_hsa043600.49327763
106ABC transporters_Homo sapiens_hsa020100.48290890
107Steroid biosynthesis_Homo sapiens_hsa001000.47608566
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.47413298
109Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47260942
110Melanogenesis_Homo sapiens_hsa049160.47137099
111Glioma_Homo sapiens_hsa052140.47011264
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46469757
113Inositol phosphate metabolism_Homo sapiens_hsa005620.46391405
114Arginine and proline metabolism_Homo sapiens_hsa003300.46312566
115Adipocytokine signaling pathway_Homo sapiens_hsa049200.46252390
116Pentose phosphate pathway_Homo sapiens_hsa000300.45674074
117Fat digestion and absorption_Homo sapiens_hsa049750.45290621
118Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44952617
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.44749782
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.44332839
121Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.43902857
122Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42479380
123Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.41557000
124Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.41491217

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