CRELD2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maintenance of protein localization in endoplasmic reticulum (GO:0035437)7.59184806
2Golgi transport vesicle coating (GO:0048200)7.46474411
3COPI coating of Golgi vesicle (GO:0048205)7.46474411
4protein retention in ER lumen (GO:0006621)6.23107646
5signal peptide processing (GO:0006465)5.56754528
6activation of signaling protein activity involved in unfolded protein response (GO:0006987)5.26903491
7positive regulation of nuclease activity (GO:0032075)5.19073119
8ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)5.13198312
9COPII vesicle coating (GO:0048208)4.88042541
10regulation of nuclease activity (GO:0032069)4.85431402
11endoplasmic reticulum unfolded protein response (GO:0030968)4.73658921
12cellular response to unfolded protein (GO:0034620)4.63686716
13DNA deamination (GO:0045006)4.49750312
14cellular response to topologically incorrect protein (GO:0035967)4.49303491
15exocrine pancreas development (GO:0031017)4.41176323
16ER-nucleus signaling pathway (GO:0006984)4.23959841
17protein maturation by protein folding (GO:0022417)4.23392658
18proline biosynthetic process (GO:0006561)4.06155186
19response to endoplasmic reticulum stress (GO:0034976)4.03245147
20GDP-mannose metabolic process (GO:0019673)4.03139842
21folic acid-containing compound biosynthetic process (GO:0009396)4.01134053
22sequestering of metal ion (GO:0051238)3.99239253
23retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.94006236
24protein N-linked glycosylation via asparagine (GO:0018279)3.91592637
25amyloid precursor protein catabolic process (GO:0042987)3.89789616
26negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.87832575
27peptidyl-asparagine modification (GO:0018196)3.87624340
28response to unfolded protein (GO:0006986)3.77036794
29positive regulation of prostaglandin secretion (GO:0032308)3.70925928
30regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022353.70012860
31response to topologically incorrect protein (GO:0035966)3.67419926
32cell redox homeostasis (GO:0045454)3.65734473
33UDP-N-acetylglucosamine metabolic process (GO:0006047)3.61609192
34protein N-linked glycosylation (GO:0006487)3.56428861
35ER overload response (GO:0006983)3.44011122
36SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.37883082
37pseudouridine synthesis (GO:0001522)3.28074254
38protein targeting to ER (GO:0045047)3.27642541
39cotranslational protein targeting to membrane (GO:0006613)3.24596531
40protein localization to endoplasmic reticulum (GO:0070972)3.13511270
414-hydroxyproline metabolic process (GO:0019471)3.12984065
42establishment of protein localization to endoplasmic reticulum (GO:0072599)3.11675437
43formation of translation preinitiation complex (GO:0001731)3.11601229
44pteridine-containing compound biosynthetic process (GO:0042559)3.10827658
45water-soluble vitamin biosynthetic process (GO:0042364)3.09917298
46proline metabolic process (GO:0006560)3.01884670
47glutathione biosynthetic process (GO:0006750)2.99085183
48fucosylation (GO:0036065)2.93270521
49cytidine metabolic process (GO:0046087)2.92804548
50cytidine catabolic process (GO:0006216)2.92804548
51cytidine deamination (GO:0009972)2.92804548
52protein autoprocessing (GO:0016540)2.89806847
53GTP biosynthetic process (GO:0006183)2.86628463
54metallo-sulfur cluster assembly (GO:0031163)2.86596368
55iron-sulfur cluster assembly (GO:0016226)2.86596368
56membrane protein intracellular domain proteolysis (GO:0031293)2.85829400
57vesicle coating (GO:0006901)2.83973890
58positive regulation of icosanoid secretion (GO:0032305)2.83847193
59folic acid metabolic process (GO:0046655)2.83080321
60mitochondrial respiratory chain complex I assembly (GO:0032981)2.81685741
61NADH dehydrogenase complex assembly (GO:0010257)2.81685741
62mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.81685741
63tetrahydrofolate metabolic process (GO:0046653)2.80623877
64maintenance of protein localization in organelle (GO:0072595)2.79811783
65positive regulation of systemic arterial blood pressure (GO:0003084)2.78818435
66nucleotide-sugar biosynthetic process (GO:0009226)2.78802787
67chaperone-mediated protein folding (GO:0061077)2.78623419
68glycine metabolic process (GO:0006544)2.78199418
69regulation of prostaglandin secretion (GO:0032306)2.76698548
70virion attachment to host cell (GO:0019062)2.71998222
71adhesion of symbiont to host cell (GO:0044650)2.71998222
72lipopolysaccharide biosynthetic process (GO:0009103)2.71976777
73nonribosomal peptide biosynthetic process (GO:0019184)2.71568482
74negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)2.69613321
75protein complex biogenesis (GO:0070271)2.69072901
76apoptotic cell clearance (GO:0043277)2.68814153
77positive regulation of T cell mediated cytotoxicity (GO:0001916)2.68306931
78nucleobase biosynthetic process (GO:0046112)2.67379258
79intestinal epithelial cell development (GO:0060576)2.67164221
80serine family amino acid biosynthetic process (GO:0009070)2.66928698
81pyrimidine ribonucleoside catabolic process (GO:0046133)2.65186215
82mitochondrial calcium ion transport (GO:0006851)2.64859909
83mitochondrial respiratory chain complex assembly (GO:0033108)2.63839120
84daunorubicin metabolic process (GO:0044597)2.63270306
85polyketide metabolic process (GO:0030638)2.63270306
86doxorubicin metabolic process (GO:0044598)2.63270306
87NIK/NF-kappaB signaling (GO:0038061)2.62581369
88UTP biosynthetic process (GO:0006228)2.61407464
89positive regulation of monocyte chemotaxis (GO:0090026)2.60938761
90antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.59841124
91ER to Golgi vesicle-mediated transport (GO:0006888)2.58845741
92sulfur amino acid catabolic process (GO:0000098)2.58814950
93protein folding (GO:0006457)2.58408001
94positive regulation of calcium ion import (GO:0090280)2.57983345
95antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.57782129
96antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.57782129
97intestinal cholesterol absorption (GO:0030299)2.56480903
98L-serine metabolic process (GO:0006563)2.56152856
99positive regulation of fatty acid transport (GO:2000193)2.55937999
100folic acid-containing compound metabolic process (GO:0006760)2.54649465
101tooth mineralization (GO:0034505)2.54357372
102base-excision repair, AP site formation (GO:0006285)2.53137324
103nucleotide-sugar metabolic process (GO:0009225)2.53123076
104antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)2.52769861
105complement activation, classical pathway (GO:0006958)2.52580190
106valine metabolic process (GO:0006573)2.52137305
107purine nucleobase biosynthetic process (GO:0009113)2.51066188
108ribosome assembly (GO:0042255)2.49746422
109adhesion of symbiont to host (GO:0044406)2.48848349
110negative regulation of catenin import into nucleus (GO:0035414)2.48643266
111DNA strand elongation involved in DNA replication (GO:0006271)2.48325378
112amyloid precursor protein metabolic process (GO:0042982)2.48216820
113antibacterial humoral response (GO:0019731)2.48194434
114response to testosterone (GO:0033574)2.47540680
115negative regulation of peptidyl-serine phosphorylation (GO:0033137)2.47123354
116translation (GO:0006412)2.46776004
117regulation of apoptotic process involved in morphogenesis (GO:1902337)2.46104043
118glyoxylate metabolic process (GO:0046487)2.45563511
119L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.45165275
120antigen processing and presentation of peptide antigen via MHC class I (GO:0002474)2.44168989
121peptide catabolic process (GO:0043171)2.44014815
122UV protection (GO:0009650)2.43610581
123guanosine-containing compound biosynthetic process (GO:1901070)2.41935549
124type B pancreatic cell proliferation (GO:0044342)2.41594588
125antimicrobial humoral response (GO:0019730)2.41225231
126leukocyte apoptotic process (GO:0071887)2.39856281
127chaperone mediated protein folding requiring cofactor (GO:0051085)2.39850441
128maternal placenta development (GO:0001893)2.39326264
129galactose catabolic process (GO:0019388)2.38983196
130regulation of T cell mediated cytotoxicity (GO:0001914)2.36203589
131peptidyl-proline hydroxylation (GO:0019511)2.36026728
132DNA strand elongation (GO:0022616)2.35767392
133telomere maintenance via semi-conservative replication (GO:0032201)2.35224410
134pteridine-containing compound metabolic process (GO:0042558)2.35010175
135L-alpha-amino acid transmembrane transport (GO:1902475)2.34569701
136antigen processing and presentation of endogenous antigen (GO:0019883)2.33474351
137lymphocyte apoptotic process (GO:0070227)2.32927891
138tRNA aminoacylation for protein translation (GO:0006418)2.31982308
139pyrimidine nucleoside monophosphate biosynthetic process (GO:0009130)2.31725595
140T cell apoptotic process (GO:0070231)2.31453274
141positive regulation of protein kinase C signaling (GO:0090037)2.31258768
142deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.30718929
143RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.30422718
144tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.30422718
145regulation of translational fidelity (GO:0006450)2.30394938
146response to food (GO:0032094)2.30142519
147protein carboxylation (GO:0018214)2.29922489
148peptidyl-glutamic acid carboxylation (GO:0017187)2.29922489
149fusion of sperm to egg plasma membrane (GO:0007342)2.29790530
150UTP metabolic process (GO:0046051)2.29174680
151L-methionine salvage (GO:0071267)2.29047416
152L-methionine biosynthetic process (GO:0071265)2.29047416
153amino acid salvage (GO:0043102)2.29047416
154energy coupled proton transport, down electrochemical gradient (GO:0015985)2.28298503
155ATP synthesis coupled proton transport (GO:0015986)2.28298503
156protein localization to kinetochore (GO:0034501)2.28253144
157mannosylation (GO:0097502)2.28247929
158ribosomal small subunit biogenesis (GO:0042274)2.27572586
159pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.26963774
160one-carbon metabolic process (GO:0006730)2.26613194
161amino acid activation (GO:0043038)2.26545371
162tRNA aminoacylation (GO:0043039)2.26545371
163deoxyribose phosphate biosynthetic process (GO:0046385)2.25290653
1642-deoxyribonucleotide biosynthetic process (GO:0009265)2.25290653
165cellular response to glucose starvation (GO:0042149)2.25151324
166pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.23610400
167aminoglycoside antibiotic metabolic process (GO:0030647)2.23232197
168cellular response to ATP (GO:0071318)2.22372823
169regulation of cellular amino acid metabolic process (GO:0006521)2.21978716
170ribosome biogenesis (GO:0042254)2.19849829
171sulfur amino acid biosynthetic process (GO:0000097)2.19847571
172dolichol-linked oligosaccharide biosynthetic process (GO:0006488)2.19607376
173fucose metabolic process (GO:0006004)2.19385034
174primary alcohol catabolic process (GO:0034310)2.18966188
175regulation of cellular extravasation (GO:0002691)2.18673851
176tumor necrosis factor-mediated signaling pathway (GO:0033209)2.17255074
177pentose metabolic process (GO:0019321)2.17050502
178arginine metabolic process (GO:0006525)2.17002866
179positive regulation of defense response to virus by host (GO:0002230)2.16195235
180positive regulation of digestive system process (GO:0060456)2.15620833
181RNA destabilization (GO:0050779)2.14668693
182positive regulation of lymphocyte apoptotic process (GO:0070230)2.14471108
183autophagic vacuole fusion (GO:0000046)2.14273425

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.01257151
2EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.34856570
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.20103862
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.92095116
5JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.79476728
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.76737902
7NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.75489684
8TP63_17297297_ChIP-ChIP_HaCaT_Human2.50991667
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.48666745
10ETS1_20019798_ChIP-Seq_JURKAT_Human2.46114083
11MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.44970104
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.44932193
13MYC_18358816_ChIP-ChIP_MESCs_Mouse2.42097997
14LXR_22292898_ChIP-Seq_THP-1_Human2.41315895
15EST1_17652178_ChIP-ChIP_JURKAT_Human2.33671366
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.20356239
17TET1_21451524_ChIP-Seq_MESCs_Mouse2.17910007
18RARG_19884340_ChIP-ChIP_MEFs_Mouse2.09588705
19FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.05628266
20SRY_22984422_ChIP-ChIP_TESTIS_Rat2.05376664
21FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.04093496
22MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03696626
23P68_20966046_ChIP-Seq_HELA_Human2.03613029
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.99373522
25GABP_19822575_ChIP-Seq_HepG2_Human1.97682358
26BCL6_27268052_Chip-Seq_Bcells_Human1.96206795
27DCP1A_22483619_ChIP-Seq_HELA_Human1.93121874
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.89267933
29CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.89209560
30VDR_23849224_ChIP-Seq_CD4+_Human1.86895201
31E2F1_18555785_ChIP-Seq_MESCs_Mouse1.86002610
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.85130819
33BCOR_27268052_Chip-Seq_Bcells_Human1.81588395
34ELF1_17652178_ChIP-ChIP_JURKAT_Human1.78147139
35CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.77016167
36ELF1_20517297_ChIP-Seq_JURKAT_Human1.76990994
37SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.76828571
38XRN2_22483619_ChIP-Seq_HELA_Human1.76282668
39PPARA_22158963_ChIP-Seq_LIVER_Mouse1.75410070
40E2F1_20622854_ChIP-Seq_HELA_Human1.67446642
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67307375
42MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66148699
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65572608
44CTCF_26484167_Chip-Seq_Bcells_Mouse1.65242577
45ELK3_25401928_ChIP-Seq_HUVEC_Human1.62974136
46TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58607434
47RXR_22158963_ChIP-Seq_LIVER_Mouse1.58040599
48PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.57088667
49EGR1_19374776_ChIP-ChIP_THP-1_Human1.56955552
50DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.55810303
51* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55545430
52* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.55166312
53YY1_22570637_ChIP-Seq_MALME-3M_Human1.54976112
54MYC_22102868_ChIP-Seq_BL_Human1.54583190
55E2F4_17652178_ChIP-ChIP_JURKAT_Human1.54145362
56CTCF_18555785_ChIP-Seq_MESCs_Mouse1.53270899
57KDM5A_27292631_Chip-Seq_BREAST_Human1.53245659
58FOXP3_21729870_ChIP-Seq_TREG_Human1.51377281
59CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.50196737
60RACK7_27058665_Chip-Seq_MCF-7_Human1.50053586
61PHF8_20622854_ChIP-Seq_HELA_Human1.49054448
62SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48678004
63TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.47683311
64FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.46545684
65HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.44528057
66TFEB_21752829_ChIP-Seq_HELA_Human1.44484454
67SA1_27219007_Chip-Seq_ERYTHROID_Human1.44299795
68ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.44099536
69ERG_20887958_ChIP-Seq_HPC-7_Mouse1.41038893
70SRF_21415370_ChIP-Seq_HL-1_Mouse1.37938850
71P300_27268052_Chip-Seq_Bcells_Human1.35364650
72AR_21909140_ChIP-Seq_LNCAP_Human1.34495336
73CTCF_20526341_ChIP-Seq_ESCs_Human1.34259452
74SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.33804584
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.33688309
76CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.33609977
77SA1_27219007_Chip-Seq_Bcells_Human1.33588860
78TP53_22127205_ChIP-Seq_IMR90_Human1.32600799
79ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.32278965
80RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.31986026
81KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.31258653
82RARB_24833708_ChIP-Seq_LIVER_Mouse1.30999624
83IRF8_22096565_ChIP-ChIP_GC-B_Human1.28908180
84RARA_24833708_ChIP-Seq_LIVER_Mouse1.28405812
85E2F1_21310950_ChIP-Seq_MCF-7_Human1.27467094
86PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.27194719
87CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.27092081
88CTCF_21964334_Chip-Seq_Bcells_Human1.26685866
89SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.26343158
90SMC3_22415368_ChIP-Seq_MEFs_Mouse1.26282169
91* NANOG_18555785_ChIP-Seq_MESCs_Mouse1.25586643
92POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25563310
93STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25082406
94CTCF_27219007_Chip-Seq_Bcells_Human1.23604482
95CTCF_27219007_Chip-Seq_ERYTHROID_Human1.23285570
96TTF2_22483619_ChIP-Seq_HELA_Human1.23219706
97TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.22561827
98FOXP1_21924763_ChIP-Seq_HESCs_Human1.21980424
99EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.21711559
100TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.21545440
101DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21107254
102ERA_21632823_ChIP-Seq_H3396_Human1.19274826
103SMC4_20622854_ChIP-Seq_HELA_Human1.19079777
104BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18521819
105CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.17424090
106THAP11_20581084_ChIP-Seq_MESCs_Mouse1.16514988
107THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.16291609
108* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.16041950
109HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16034829
110ELK1_19687146_ChIP-ChIP_HELA_Human1.15454101
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15426416
112STAT4_19710469_ChIP-ChIP_TH1__Mouse1.14698186
113BMI1_19503595_ChIP-Seq_MEFsC_Mouse1.13965458
114ETS1_21867929_ChIP-Seq_TH2_Mouse1.13591549
115EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13351948
116HOXB4_20404135_ChIP-ChIP_EML_Mouse1.13238825
117PU.1_20513432_ChIP-Seq_Bcells_Mouse1.13004568
118PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.12739418
119* YY1_21170310_ChIP-Seq_MESCs_Mouse1.12423425
120KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12241133
121CTCF_21964334_ChIP-Seq_BJAB-B_Human1.12087839
122MAF_26560356_Chip-Seq_TH2_Human1.09687905
123HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.09511056
124* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08578605
125SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.08386836
126CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.08177772
127* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07941040
128TP63_22573176_ChIP-Seq_HFKS_Human1.07287601
129CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07100654
130MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.06437966
131CIITA_25753668_ChIP-Seq_RAJI_Human1.06015654
132RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05992913
133MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.05749126
134TBX5_21415370_ChIP-Seq_HL-1_Mouse1.04921273
135UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.04218677
136ERG_21242973_ChIP-ChIP_JURKAT_Human1.04109141
137E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.03998761
138FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.03780437
139VDR_21846776_ChIP-Seq_THP-1_Human1.03582608
140RAC3_21632823_ChIP-Seq_H3396_Human1.03418649
141IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.02754988
142BP1_19119308_ChIP-ChIP_Hs578T_Human1.02006962
143TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.01510214
144RAD21_21589869_ChIP-Seq_MESCs_Mouse1.01221486
145CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.99289956
146SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.98739388
147RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.98652801
148SPI1_23547873_ChIP-Seq_NB4_Human0.98205602
149GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.97385671
150IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.96574794
151* LXR_22158963_ChIP-Seq_LIVER_Mouse0.96370036
152CLOCK_20551151_ChIP-Seq_293T_Human0.96307299
153CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95302915
154CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95189091
155SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.94762893
156* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human0.94705351
157PADI4_21655091_ChIP-ChIP_MCF-7_Human0.93301313
158* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.91429732
159POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.90797869
160STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.90747886
161ELK1_22589737_ChIP-Seq_MCF10A_Human0.90084079
162GATA1_22383799_ChIP-Seq_G1ME_Mouse0.89528079
163ATF3_27146783_Chip-Seq_COLON_Human0.87796617
164RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.87794335

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.26544933
2MP0008875_abnormal_xenobiotic_pharmacok3.56104130
3MP0005220_abnormal_exocrine_pancreas3.18371626
4MP0005503_abnormal_tendon_morphology3.00308196
5MP0005365_abnormal_bile_salt2.75920627
6MP0002876_abnormal_thyroid_physiology2.60355645
7MP0004264_abnormal_extraembryonic_tissu2.57489965
8MP0004957_abnormal_blastocyst_morpholog2.51760854
9MP0002139_abnormal_hepatobiliary_system2.50487995
10MP0001661_extended_life_span2.45826637
11MP0001666_abnormal_nutrient_absorption2.36277689
12MP0003806_abnormal_nucleotide_metabolis2.29563892
13MP0004858_abnormal_nervous_system2.06147063
14MP0002877_abnormal_melanocyte_morpholog1.92867274
15MP0005083_abnormal_biliary_tract1.91349258
16MP0000013_abnormal_adipose_tissue1.90745767
17MP0002693_abnormal_pancreas_physiology1.90629781
18MP0001542_abnormal_bone_strength1.86035362
19MP0001944_abnormal_pancreas_morphology1.84925508
20MP0003279_aneurysm1.83410063
21MP0009785_altered_susceptibility_to1.80190815
22MP0009384_cardiac_valve_regurgitation1.78163196
23MP0010352_gastrointestinal_tract_polyps1.74510149
24MP0009764_decreased_sensitivity_to1.74003085
25MP0006054_spinal_hemorrhage1.73321235
26MP0003195_calcinosis1.68458661
27MP0009840_abnormal_foam_cell1.68140901
28MP0003186_abnormal_redox_activity1.66415572
29MP0003111_abnormal_nucleus_morphology1.66191337
30MP0003077_abnormal_cell_cycle1.66036994
31MP0002933_joint_inflammation1.62167524
32MP0002148_abnormal_hypersensitivity_rea1.62141158
33MP0008058_abnormal_DNA_repair1.59525331
34MP0005085_abnormal_gallbladder_physiolo1.58960542
35MP0010094_abnormal_chromosome_stability1.55568217
36MP0005360_urolithiasis1.53095751
37MP0000003_abnormal_adipose_tissue1.50431526
38MP0009643_abnormal_urine_homeostasis1.50005934
39MP0000681_abnormal_thyroid_gland1.45193542
40MP0003705_abnormal_hypodermis_morpholog1.43011092
41MP0003868_abnormal_feces_composition1.41374548
42MP0005058_abnormal_lysosome_morphology1.40183360
43MP0000490_abnormal_crypts_of1.39010902
44MP0000750_abnormal_muscle_regeneration1.37804176
45MP0002089_abnormal_postnatal_growth/wei1.36698202
46MP0005171_absent_coat_pigmentation1.35777845
47MP0005076_abnormal_cell_differentiation1.35559002
48MP0008007_abnormal_cellular_replicative1.32319451
49MP0004947_skin_inflammation1.30217568
50MP0004043_abnormal_pH_regulation1.28853540
51MP0009278_abnormal_bone_marrow1.28833376
52MP0005387_immune_system_phenotype1.27869502
53MP0001790_abnormal_immune_system1.27869502
54MP0000613_abnormal_salivary_gland1.27405787
55MP0003252_abnormal_bile_duct1.27295810
56MP0003300_gastrointestinal_ulcer1.26702688
57MP0005310_abnormal_salivary_gland1.23049776
58MP0003436_decreased_susceptibility_to1.20632836
59MP0005451_abnormal_body_composition1.20126751
60MP0009333_abnormal_splenocyte_physiolog1.19496235
61MP0005332_abnormal_amino_acid1.19190234
62MP0001764_abnormal_homeostasis1.18276063
63MP0005410_abnormal_fertilization1.18198123
64MP0000609_abnormal_liver_physiology1.17300305
65MP0003329_amyloid_beta_deposits1.16927227
66MP0005508_abnormal_skeleton_morphology1.15951391
67MP0008932_abnormal_embryonic_tissue1.15642433
68MP0001730_embryonic_growth_arrest1.14989699
69MP0005671_abnormal_response_to1.14943109
70MP0004782_abnormal_surfactant_physiolog1.13362674
71MP0005023_abnormal_wound_healing1.13103878
72MP0005390_skeleton_phenotype1.12906451
73MP0001533_abnormal_skeleton_physiology1.11429822
74MP0001919_abnormal_reproductive_system1.09637966
75MP0005319_abnormal_enzyme/_coenzyme1.07629398
76MP0003283_abnormal_digestive_organ1.07527371
77MP0005636_abnormal_mineral_homeostasis1.07206631
78MP0000678_abnormal_parathyroid_gland1.06813767
79MP0001502_abnormal_circadian_rhythm1.06160941
80MP0001835_abnormal_antigen_presentation1.05963041
81MP0005584_abnormal_enzyme/coenzyme_acti1.05620071
82MP0000538_abnormal_urinary_bladder1.05443090
83MP0005000_abnormal_immune_tolerance1.05332866
84MP0005647_abnormal_sex_gland1.04894472
85MP0000747_muscle_weakness1.02547523
86MP0003718_maternal_effect1.02037381
87MP0001845_abnormal_inflammatory_respons1.01694423
88MP0001243_abnormal_dermal_layer1.01169473
89MP0002723_abnormal_immune_serum1.00860788
90MP0008438_abnormal_cutaneous_collagen1.00434448
91MP0010234_abnormal_vibrissa_follicle0.99707461
92MP0001663_abnormal_digestive_system0.99586269
93MP0001929_abnormal_gametogenesis0.98890511
94MP0003183_abnormal_peptide_metabolism0.98882630
95MP0003890_abnormal_embryonic-extraembry0.98426489
96MP0001958_emphysema0.98152648
97MP0000598_abnormal_liver_morphology0.97020289
98MP0003566_abnormal_cell_adhesion0.96878210
99MP0002019_abnormal_tumor_incidence0.96763032
100MP0002060_abnormal_skin_morphology0.96428886
101MP0008057_abnormal_DNA_replication0.95986561
102MP0000350_abnormal_cell_proliferation0.95582890
103MP0001800_abnormal_humoral_immune0.95529939
104MP0002295_abnormal_pulmonary_circulatio0.95087179
105MP0001756_abnormal_urination0.94910852
106MP0005408_hypopigmentation0.93687168
107MP0002108_abnormal_muscle_morphology0.93470423
108MP0002452_abnormal_antigen_presenting0.93288357
109MP0001849_ear_inflammation0.93107702
110MP0000858_altered_metastatic_potential0.92611967
111MP0000358_abnormal_cell_content/0.92459303
112MP0003786_premature_aging0.91303968
113MP0001873_stomach_inflammation0.91281951
114MP0002078_abnormal_glucose_homeostasis0.88111716
115MP0001986_abnormal_taste_sensitivity0.88011819
116MP0003763_abnormal_thymus_physiology0.87958103
117MP0010307_abnormal_tumor_latency0.87784214
118MP0002080_prenatal_lethality0.87507748
119MP0005166_decreased_susceptibility_to0.86677696
120MP0002138_abnormal_hepatobiliary_system0.85437191
121MP0001905_abnormal_dopamine_level0.85300371
122MP0001819_abnormal_immune_cell0.84876277
123MP0002166_altered_tumor_susceptibility0.84474412
124MP0001145_abnormal_male_reproductive0.84256876
125MP0008872_abnormal_physiological_respon0.83837819
126MP0003453_abnormal_keratinocyte_physiol0.83720519
127MP0000313_abnormal_cell_death0.82558987
128MP0002420_abnormal_adaptive_immunity0.82456701
129MP0005275_abnormal_skin_tensile0.82370795
130MP0008469_abnormal_protein_level0.81992593
131MP0005645_abnormal_hypothalamus_physiol0.81587663
132MP0001697_abnormal_embryo_size0.81306959
133MP0000685_abnormal_immune_system0.80576097
134MP0000604_amyloidosis0.79249004
135MP0010155_abnormal_intestine_physiology0.78480240
136MP0010329_abnormal_lipoprotein_level0.77857691
137MP0002928_abnormal_bile_duct0.77653985
138MP0003075_altered_response_to0.77514188
139MP0003646_muscle_fatigue0.77251107
140MP0002653_abnormal_ependyma_morphology0.77215805
141MP0005389_reproductive_system_phenotype0.77149301
142MP0005381_digestive/alimentary_phenotyp0.76130387
143MP0003656_abnormal_erythrocyte_physiolo0.76103722
144MP0000653_abnormal_sex_gland0.75765069
145MP0003045_fibrosis0.75575363
146MP0010386_abnormal_urinary_bladder0.75574768
147MP0003123_paternal_imprinting0.75384703
148MP0004272_abnormal_basement_membrane0.75025611
149MP0006036_abnormal_mitochondrial_physio0.74757048
150MP0002210_abnormal_sex_determination0.74737201
151MP0003866_abnormal_defecation0.74562294
152MP0005621_abnormal_cell_physiology0.73353994
153MP0001765_abnormal_ion_homeostasis0.72669799
154MP0005084_abnormal_gallbladder_morpholo0.72501970
155MP0005395_other_phenotype0.71131495
156MP0005380_embryogenesis_phenotype0.70874130
157MP0001672_abnormal_embryogenesis/_devel0.70874130
158MP0002160_abnormal_reproductive_system0.69954985
159MP0003959_abnormal_lean_body0.68793373
160MP0005384_cellular_phenotype0.68018497
161MP0002136_abnormal_kidney_physiology0.67454895
162MP0005025_abnormal_response_to0.64918312

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the intrinsic pathway (HP:0010989)4.22054304
2Hypoglycemic coma (HP:0001325)3.82802006
3Abnormality of liposaccharide metabolism (HP:0010968)3.56420778
4Abnormality of glycosphingolipid metabolism (HP:0004343)3.56420778
5Abnormality of glycolipid metabolism (HP:0010969)3.56420778
6Testicular atrophy (HP:0000029)3.54800516
7Abnormal protein glycosylation (HP:0012346)3.51821911
8Abnormal glycosylation (HP:0012345)3.51821911
9Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.51821911
10Abnormal protein N-linked glycosylation (HP:0012347)3.51821911
11Type I transferrin isoform profile (HP:0003642)3.39254956
12Abnormality of aromatic amino acid family metabolism (HP:0004338)3.32115257
13Thrombocytosis (HP:0001894)3.29669427
14Hyperinsulinemic hypoglycemia (HP:0000825)3.23153961
15Vacuolated lymphocytes (HP:0001922)3.16084668
16Abnormality of the common coagulation pathway (HP:0010990)3.12941872
17Type II lissencephaly (HP:0007260)3.00197219
18Degeneration of anterior horn cells (HP:0002398)3.00055620
19Abnormality of the anterior horn cell (HP:0006802)3.00055620
20Reduced antithrombin III activity (HP:0001976)2.99633756
21Stridor (HP:0010307)2.97189785
22Hypoglycemic seizures (HP:0002173)2.93121512
23Progressive muscle weakness (HP:0003323)2.91529752
24Abnormality of monocarboxylic acid metabolism (HP:0010996)2.82687872
25Redundant skin (HP:0001582)2.79616550
26Generalized aminoaciduria (HP:0002909)2.74016725
27Chronic bronchitis (HP:0004469)2.72075405
28Urinary glycosaminoglycan excretion (HP:0003541)2.65320633
29Mucopolysacchariduria (HP:0008155)2.65320633
30Late onset (HP:0003584)2.61553322
31Premature rupture of membranes (HP:0001788)2.58627669
32Dysostosis multiplex (HP:0000943)2.56615534
33Microretrognathia (HP:0000308)2.52478510
34Mitochondrial inheritance (HP:0001427)2.52453305
35Mesangial abnormality (HP:0001966)2.47224871
36Abnormality of endocrine pancreas physiology (HP:0012093)2.46633122
37Abnormality of the pancreatic islet cells (HP:0006476)2.46633122
38Hypoplasia of the pons (HP:0012110)2.46077625
39Achilles tendon contracture (HP:0001771)2.45475195
40Aplastic anemia (HP:0001915)2.44565758
41Fat malabsorption (HP:0002630)2.44249219
42Poor head control (HP:0002421)2.43958839
43Ketosis (HP:0001946)2.43642658
44Increased muscle lipid content (HP:0009058)2.43032859
45Opisthotonus (HP:0002179)2.40817894
46Hyperglycemia (HP:0003074)2.40483516
47Down-sloping shoulders (HP:0200021)2.39239435
48Intrahepatic cholestasis (HP:0001406)2.39215208
49Gout (HP:0001997)2.38646472
50Abnormal mitochondria in muscle tissue (HP:0008316)2.38231717
51Concave nail (HP:0001598)2.36950287
52Ketoacidosis (HP:0001993)2.36675228
53Carpal bone hypoplasia (HP:0001498)2.34811549
54Short femoral neck (HP:0100864)2.30477135
55Abnormality of mucopolysaccharide metabolism (HP:0011020)2.28016717
56Abnormality of polysaccharide metabolism (HP:0011012)2.28016717
57Abnormality of glycosaminoglycan metabolism (HP:0004371)2.28016717
58Abnormality of glutamine family amino acid metabolism (HP:0010902)2.27865099
59Hepatic necrosis (HP:0002605)2.27766871
60Bronchitis (HP:0012387)2.27066082
61Hypobetalipoproteinemia (HP:0003563)2.25919120
62Nasal polyposis (HP:0100582)2.23588902
63Multiple enchondromatosis (HP:0005701)2.23540557
64J-shaped sella turcica (HP:0002680)2.22936192
65Hepatocellular necrosis (HP:0001404)2.22745448
66Beaking of vertebral bodies (HP:0004568)2.22240217
67Steatorrhea (HP:0002570)2.22111621
68Increased intramyocellular lipid droplets (HP:0012240)2.21099898
69Thoracolumbar scoliosis (HP:0002944)2.20414866
70Abnormality of the Achilles tendon (HP:0005109)2.19902607
71Symptomatic seizures (HP:0011145)2.19289332
72Hypokinesia (HP:0002375)2.16911652
73Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.16892474
74Abnormality of the pons (HP:0007361)2.16037560
75Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.15689936
76Abnormality of T cell physiology (HP:0011840)2.15550726
77Abnormality of subcutaneous fat tissue (HP:0001001)2.15508202
78Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.14648347
79Cerebral palsy (HP:0100021)2.13835654
80Acute necrotizing encephalopathy (HP:0006965)2.13541910
81Increased neuronal autofluorescent lipopigment (HP:0002074)2.10225341
82Hand muscle atrophy (HP:0009130)2.09467356
83Insulin resistance (HP:0000855)2.08156976
84Aplasia/Hypoplasia of the sacrum (HP:0008517)2.07743429
85Increased CSF lactate (HP:0002490)2.05974098
86Abnormal pancreas size (HP:0012094)2.05282709
87Malnutrition (HP:0004395)2.04861612
88Secondary amenorrhea (HP:0000869)2.04545853
89Vertebral compression fractures (HP:0002953)1.97467302
90Atrophic scars (HP:0001075)1.97374243
91Abnormality of transition element cation homeostasis (HP:0011030)1.97311806
92Exocrine pancreatic insufficiency (HP:0001738)1.97250331
93Recurrent bronchitis (HP:0002837)1.97059867
94Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.96740734
95Decreased activity of mitochondrial respiratory chain (HP:0008972)1.96145796
96Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.96145796
97Abnormality of small intestinal villus morphology (HP:0011472)1.95296138
98Villous atrophy (HP:0011473)1.95296138
99Lipid accumulation in hepatocytes (HP:0006561)1.95194263
100Increased serum ferritin (HP:0003281)1.94948502
101Hyperalaninemia (HP:0003348)1.94355627
102Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.94355627
103Abnormality of alanine metabolism (HP:0010916)1.94355627
104Flat capital femoral epiphysis (HP:0003370)1.94221814
105B lymphocytopenia (HP:0010976)1.93747331
106Abnormality of B cell number (HP:0010975)1.93747331
107Renal Fanconi syndrome (HP:0001994)1.92946144
10811 pairs of ribs (HP:0000878)1.92830309
109Acute encephalopathy (HP:0006846)1.92448758
110Breast hypoplasia (HP:0003187)1.91361919
111Joint stiffness (HP:0001387)1.90612095
112Trismus (HP:0000211)1.90119400
113Hyperglycinuria (HP:0003108)1.90060201
114Oral leukoplakia (HP:0002745)1.89939392
115Aplasia of the musculature (HP:0100854)1.89486054
116Abnormality of the nasal mucosa (HP:0000433)1.89330379
117Pancreatitis (HP:0001733)1.88800070
118Prolonged neonatal jaundice (HP:0006579)1.88442866
119Abnormality of sulfur amino acid metabolism (HP:0004339)1.88002492
120Severe muscular hypotonia (HP:0006829)1.83290555
121Increased serum lactate (HP:0002151)1.83109762
122Insulin-resistant diabetes mellitus (HP:0000831)1.82522252
123Nonimmune hydrops fetalis (HP:0001790)1.82350011
124Decreased electroretinogram (ERG) amplitude (HP:0000654)1.82159719
125Abnormality of pyrimidine metabolism (HP:0004353)1.81902853
126Ovoid vertebral bodies (HP:0003300)1.81754981
127Delayed CNS myelination (HP:0002188)1.80787560
128Xanthomatosis (HP:0000991)1.80477647
129Increased cerebral lipofuscin (HP:0011813)1.80471951
130Elbow flexion contracture (HP:0002987)1.80377044
131Megaloblastic anemia (HP:0001889)1.80298016
132Prolonged partial thromboplastin time (HP:0003645)1.80150199
133Hydroxyprolinuria (HP:0003080)1.79892346
134Abnormality of proline metabolism (HP:0010907)1.79892346
135Ankle contracture (HP:0006466)1.79566570
136Amelogenesis imperfecta (HP:0000705)1.79187319
137Lactic acidosis (HP:0003128)1.77923312
138Abnormality of cells of the erythroid lineage (HP:0012130)1.77717898
139Abnormal number of erythroid precursors (HP:0012131)1.77072564
140Ragged-red muscle fibers (HP:0003200)1.77003941
141Hypertensive crisis (HP:0100735)1.76869697
142Cervical subluxation (HP:0003308)1.76733769
143Aplasia/hypoplasia of the femur (HP:0005613)1.76699279
144Entropion (HP:0000621)1.76102998
145Abnormal trabecular bone morphology (HP:0100671)1.75647727
146Birth length less than 3rd percentile (HP:0003561)1.75450657
147Abdominal distention (HP:0003270)1.75108157
148Abnormality of dentin (HP:0010299)1.73910608
149Complement deficiency (HP:0004431)1.73378177
150Deformed sella turcica (HP:0002681)1.73146018
151Male infertility (HP:0003251)1.72966893
152Long toe (HP:0010511)1.72916762
153Asymmetric septal hypertrophy (HP:0001670)1.72915418
154Rough bone trabeculation (HP:0100670)1.72480881
155Type I diabetes mellitus (HP:0100651)1.72380245
156Hyperammonemia (HP:0001987)1.71791995
157Elevated erythrocyte sedimentation rate (HP:0003565)1.71525725
158Cerebellar dysplasia (HP:0007033)1.70991138
159Aortic regurgitation (HP:0001659)1.70916261
160Deep venous thrombosis (HP:0002625)1.70636262
161Atelectasis (HP:0100750)1.70555086
162Abnormality of fatty-acid metabolism (HP:0004359)1.68958128
163Hyperglycinemia (HP:0002154)1.67414754
164Prominent metopic ridge (HP:0005487)1.67222320
165Interstitial pulmonary disease (HP:0006530)1.66339184
166Abnormality of alkaline phosphatase activity (HP:0004379)1.66259176
167Abnormal enzyme/coenzyme activity (HP:0012379)1.63496476
168Abnormality of dicarboxylic acid metabolism (HP:0010995)1.63077370
169Dicarboxylic aciduria (HP:0003215)1.63077370
170Abnormality of nucleobase metabolism (HP:0010932)1.62367302
171Slender long bone (HP:0003100)1.62224438
172Decreased subcutaneous fat (HP:0001002)1.61625107

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ERN17.24260537
2BCKDK3.85925375
3EIF2AK32.86702509
4NME22.82953921
5PASK2.61458207
6BUB12.41418701
7TAOK32.32156412
8SCYL22.28894108
9WEE12.22255744
10EPHA21.91579490
11EIF2AK11.82900700
12TESK11.82065285
13FLT31.79568256
14BRSK21.78647210
15TESK21.71793781
16NEK21.62696649
17MUSK1.61994669
18ADRBK21.53943360
19DDR21.50968284
20TRIB31.47289815
21MAP2K71.41556560
22IRAK31.40831537
23RPS6KA41.38873719
24STK161.38281695
25RPS6KA51.35199746
26DYRK31.33266564
27MAPKAPK31.32921267
28SMG11.30476408
29MAPK151.30211989
30PLK41.26546223
31EEF2K1.26028542
32ACVR1B1.24443443
33MAP3K91.20167627
34EPHB21.18956398
35DAPK31.18698802
36LATS11.17135171
37PIM21.17037748
38TBK11.15403191
39MAP3K31.15177620
40CDC71.14320426
41IKBKB1.10416288
42RPS6KB21.09844843
43BRAF1.09357421
44AKT31.09179073
45BLK1.07073356
46TIE11.05520076
47IKBKE1.04661718
48GRK61.04578028
49TYK21.02474566
50TTK1.02377874
51MAP3K81.01740444
52MAP2K21.00046860
53EPHA30.97393253
54JAK30.95927341
55PLK10.94996834
56TYRO30.94536355
57KDR0.93869274
58ILK0.93239998
59MAP2K60.91337335
60PKN20.91215950
61MAPK110.90171725
62FRK0.89841630
63AURKB0.88178457
64MAP2K30.86466607
65MAP3K110.86153053
66GRK10.85918272
67PIK3CG0.83874733
68INSRR0.83598030
69STK100.83400830
70PDK40.81233527
71PDK30.81233527
72CDK70.80053641
73LMTK20.79682156
74MAP3K100.78885014
75BRSK10.78785004
76TSSK60.78283337
77MST1R0.77181093
78VRK20.76582176
79WNK40.75516302
80SIK10.75462981
81ATR0.73823785
82LRRK20.73205881
83ZAP700.72101549
84NME10.72061220
85CHEK20.71523857
86PAK40.71050200
87MATK0.70374073
88RPS6KA20.70001635
89VRK10.69762652
90PRKCI0.69068535
91CSNK1G30.66761102
92MAP2K40.64803590
93MAP4K10.64365244
94AURKA0.63738298
95ABL20.62587013
96LIMK10.62189191
97TGFBR20.61475046
98RPS6KA60.60844539
99CDC42BPA0.60299589
100STK30.59659621
101PRKD20.58821623
102PIM10.58338805
103MAP3K130.56952954
104DYRK1B0.56460465
105PRKD30.56384601
106RIPK10.54846876
107MTOR0.54264148
108IRAK40.54257354
109PDPK10.53032449
110HIPK20.52606739
111BTK0.52442120
112STK38L0.52271639
113TXK0.51198801
114CDK80.50857465
115ADRBK10.50140299
116PAK20.49960819
117PDK20.49765449
118CSNK1G10.48846613
119CDK40.48021938
120RPS6KL10.47913854
121RPS6KC10.47913854
122PTK60.47002217
123CHEK10.46949496
124PRKCH0.46788171
125PRKCD0.45604455
126ARAF0.45447961
127SRPK10.44005729
128PAK10.43703410
129CSNK1A1L0.43188908
130NEK10.43121853
131MAPKAPK50.42518304
132CSNK2A10.42080271
133ZAK0.41393436
134MOS0.40273857
135MET0.40026783
136PKN10.39960199
137PRKCQ0.39901021
138CSNK2A20.39316670
139CHUK0.37995493
140FGFR40.37105115
141STK40.35995582
142CAMK2G0.35746375
143IRAK10.35692686
144PDGFRA0.35260333
145TLK10.33457537
146PRKG20.33058932
147MELK0.32393252
148MAP3K140.31280472
149PTK20.31146601
150TEC0.30391242
151CSF1R0.29906187
152MAPKAPK20.29414709
153PLK30.29102689

Predicted pathways (KEGG)

RankGene SetZ-score
1Protein export_Homo sapiens_hsa030605.63491195
2Protein processing in endoplasmic reticulum_Homo sapiens_hsa041414.15548227
3Maturity onset diabetes of the young_Homo sapiens_hsa049503.56349031
4N-Glycan biosynthesis_Homo sapiens_hsa005102.47933555
5Selenocompound metabolism_Homo sapiens_hsa004502.41359371
6Folate biosynthesis_Homo sapiens_hsa007902.39024332
7DNA replication_Homo sapiens_hsa030302.36545027
8Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.33808289
9Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.30309324
10Proteasome_Homo sapiens_hsa030502.21418624
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.16752503
12One carbon pool by folate_Homo sapiens_hsa006702.09939116
13Alcoholism_Homo sapiens_hsa050342.07119937
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.05654911
15Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.96944870
16Oxidative phosphorylation_Homo sapiens_hsa001901.80677810
17Mismatch repair_Homo sapiens_hsa034301.76246214
18Ribosome_Homo sapiens_hsa030101.68922652
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.65685208
20Intestinal immune network for IgA production_Homo sapiens_hsa046721.64148968
21Antigen processing and presentation_Homo sapiens_hsa046121.64030906
22Sulfur metabolism_Homo sapiens_hsa009201.63825279
23Other glycan degradation_Homo sapiens_hsa005111.58166277
24Primary immunodeficiency_Homo sapiens_hsa053401.58093492
25Base excision repair_Homo sapiens_hsa034101.57701390
26Pyrimidine metabolism_Homo sapiens_hsa002401.56364387
27Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.55225514
28Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.49950962
29RNA transport_Homo sapiens_hsa030131.43569743
30RNA polymerase_Homo sapiens_hsa030201.35716961
31Sulfur relay system_Homo sapiens_hsa041221.31505553
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.30332937
33Parkinsons disease_Homo sapiens_hsa050121.26418653
34Nucleotide excision repair_Homo sapiens_hsa034201.24466049
35Fat digestion and absorption_Homo sapiens_hsa049751.24074832
36Cysteine and methionine metabolism_Homo sapiens_hsa002701.21834044
37Homologous recombination_Homo sapiens_hsa034401.15558447
38Legionellosis_Homo sapiens_hsa051341.15261872
39Biosynthesis of amino acids_Homo sapiens_hsa012301.14291203
40Spliceosome_Homo sapiens_hsa030401.12924935
41Drug metabolism - other enzymes_Homo sapiens_hsa009831.10504906
42Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.09381464
43Alzheimers disease_Homo sapiens_hsa050101.09294123
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.07141939
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02476031
46Pentose phosphate pathway_Homo sapiens_hsa000301.00793047
47Vitamin B6 metabolism_Homo sapiens_hsa007500.98608549
48Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.96730566
49Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.95852135
50Chemical carcinogenesis_Homo sapiens_hsa052040.95832403
51Primary bile acid biosynthesis_Homo sapiens_hsa001200.95652900
52Tryptophan metabolism_Homo sapiens_hsa003800.94762360
53Cell cycle_Homo sapiens_hsa041100.94092387
54Fructose and mannose metabolism_Homo sapiens_hsa000510.93888214
55Glycosaminoglycan degradation_Homo sapiens_hsa005310.93574019
56Renin-angiotensin system_Homo sapiens_hsa046140.93272401
57Huntingtons disease_Homo sapiens_hsa050160.93100767
58Galactose metabolism_Homo sapiens_hsa000520.91116092
59p53 signaling pathway_Homo sapiens_hsa041150.90594565
60RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.89408819
61Caffeine metabolism_Homo sapiens_hsa002320.88133123
62NF-kappa B signaling pathway_Homo sapiens_hsa040640.87820937
63Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.86963962
64Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86389788
65Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.86330281
66Cyanoamino acid metabolism_Homo sapiens_hsa004600.84130386
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83760549
68Vibrio cholerae infection_Homo sapiens_hsa051100.83257296
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.83159883
70Protein digestion and absorption_Homo sapiens_hsa049740.82079792
71Lysosome_Homo sapiens_hsa041420.79250220
72Arginine and proline metabolism_Homo sapiens_hsa003300.79201134
73TNF signaling pathway_Homo sapiens_hsa046680.77595108
74Pentose and glucuronate interconversions_Homo sapiens_hsa000400.76608971
75ABC transporters_Homo sapiens_hsa020100.73642240
76Carbon metabolism_Homo sapiens_hsa012000.71773688
772-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.71420599
78Basal transcription factors_Homo sapiens_hsa030220.70698035
79Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.70454555
80Non-homologous end-joining_Homo sapiens_hsa034500.69327481
81Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.68005043
82Glutathione metabolism_Homo sapiens_hsa004800.67378951
83Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.67129946
84Fatty acid degradation_Homo sapiens_hsa000710.65611322
85Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.64747158
86Pancreatic secretion_Homo sapiens_hsa049720.64106739
87Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.62770984
88Purine metabolism_Homo sapiens_hsa002300.62675482
89RNA degradation_Homo sapiens_hsa030180.59114127
90Linoleic acid metabolism_Homo sapiens_hsa005910.57814909
91Thyroid hormone synthesis_Homo sapiens_hsa049180.57244359
92Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.56668505
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.55409212
94Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.55259305
95Fanconi anemia pathway_Homo sapiens_hsa034600.54778228
96Epstein-Barr virus infection_Homo sapiens_hsa051690.54739963
97Regulation of autophagy_Homo sapiens_hsa041400.54338578
98alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.53878987
99Complement and coagulation cascades_Homo sapiens_hsa046100.53093704
100Pyruvate metabolism_Homo sapiens_hsa006200.53054548
101Prion diseases_Homo sapiens_hsa050200.52743543
102Peroxisome_Homo sapiens_hsa041460.52639917
103Starch and sucrose metabolism_Homo sapiens_hsa005000.52597310
104Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.52013429
105Metabolic pathways_Homo sapiens_hsa011000.51949149
106Histidine metabolism_Homo sapiens_hsa003400.48688964
107Phenylalanine metabolism_Homo sapiens_hsa003600.46803376
108Autoimmune thyroid disease_Homo sapiens_hsa053200.46732001
109Allograft rejection_Homo sapiens_hsa053300.46617194
110Propanoate metabolism_Homo sapiens_hsa006400.45668916
111Rheumatoid arthritis_Homo sapiens_hsa053230.44288091
112Arginine biosynthesis_Homo sapiens_hsa002200.43702417
113PPAR signaling pathway_Homo sapiens_hsa033200.43120206
114Bladder cancer_Homo sapiens_hsa052190.42803608
115Cardiac muscle contraction_Homo sapiens_hsa042600.42456057
116Graft-versus-host disease_Homo sapiens_hsa053320.41596417
117Viral carcinogenesis_Homo sapiens_hsa052030.40475991
118Herpes simplex infection_Homo sapiens_hsa051680.39682154
119Adipocytokine signaling pathway_Homo sapiens_hsa049200.38865165
120Mineral absorption_Homo sapiens_hsa049780.38423850
121Glycerolipid metabolism_Homo sapiens_hsa005610.37754389
122Vitamin digestion and absorption_Homo sapiens_hsa049770.37417273
123Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.37122228
124Apoptosis_Homo sapiens_hsa042100.36817114
125Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.34219553
126Systemic lupus erythematosus_Homo sapiens_hsa053220.34171326
127Influenza A_Homo sapiens_hsa051640.34058741
128Ovarian steroidogenesis_Homo sapiens_hsa049130.31788768
129Pertussis_Homo sapiens_hsa051330.30915133
130beta-Alanine metabolism_Homo sapiens_hsa004100.30367716
131Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.29597724
132Sphingolipid metabolism_Homo sapiens_hsa006000.29316760
133Tyrosine metabolism_Homo sapiens_hsa003500.28693334
134Small cell lung cancer_Homo sapiens_hsa052220.28467245
135Toll-like receptor signaling pathway_Homo sapiens_hsa046200.28279108
136Asthma_Homo sapiens_hsa053100.27369089
137Arachidonic acid metabolism_Homo sapiens_hsa005900.26806017
138Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.26064112
139Hepatitis C_Homo sapiens_hsa051600.24480050
140Insulin resistance_Homo sapiens_hsa049310.24324783
141Staphylococcus aureus infection_Homo sapiens_hsa051500.23802770
142Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.22300757

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