CREM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a bZIP transcription factor that binds to the cAMP responsive element found in many viral and cellular promoters. It is an important component of cAMP-mediated signal transduction during the spermatogenetic cycle, as well as other complex processes. Alternative promoter and translation initiation site usage allows this gene to exert spatial and temporal specificity to cAMP responsiveness. Multiple alternatively spliced transcript variants encoding several different isoforms have been found for this gene, with some of them functioning as activators and some as repressors of transcription. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1interferon-gamma production (GO:0032609)6.46618726
2tolerance induction (GO:0002507)5.90470648
3positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)5.49156060
4regulation of isotype switching to IgG isotypes (GO:0048302)5.17664718
5regulation of memory T cell differentiation (GO:0043380)4.87251227
6regulation of fever generation (GO:0031620)4.71028402
7DNA deamination (GO:0045006)4.66042503
8regulation of activation of Janus kinase activity (GO:0010533)4.61449698
9positive regulation of heat generation (GO:0031652)4.47110493
10G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)4.41328515
11regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450914.39950149
12positive thymic T cell selection (GO:0045059)4.38274692
13cellular response to interleukin-15 (GO:0071350)4.38110899
14regulation of vitamin D biosynthetic process (GO:0060556)4.33201811
15CD4-positive, alpha-beta T cell differentiation involved in immune response (GO:0002294)4.31166622
16T-helper cell differentiation (GO:0042093)4.31166622
17cytidine deamination (GO:0009972)4.29734382
18cytidine metabolic process (GO:0046087)4.29734382
19cytidine catabolic process (GO:0006216)4.29734382
20response to interleukin-15 (GO:0070672)4.25298842
21NIK/NF-kappaB signaling (GO:0038061)4.06079489
22regulation of immunoglobulin secretion (GO:0051023)4.03008562
23viral protein processing (GO:0019082)4.02717818
24positive regulation of chemokine biosynthetic process (GO:0045080)3.99810130
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.94637987
26response to muramyl dipeptide (GO:0032495)3.90735520
27regulation of RIG-I signaling pathway (GO:0039535)3.88958027
28positive T cell selection (GO:0043368)3.87217782
29negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.85830814
30negative regulation of cell killing (GO:0031342)3.85830814
31positive regulation of osteoclast differentiation (GO:0045672)3.84870797
32CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.84133547
33regulation of podosome assembly (GO:0071801)3.82143974
34positive regulation of prostaglandin secretion (GO:0032308)3.78898085
35positive regulation of natural killer cell mediated cytotoxicity (GO:0045954)3.78350229
36regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)3.78062741
37positive regulation of T-helper 1 type immune response (GO:0002827)3.76753146
38pyrimidine ribonucleoside catabolic process (GO:0046133)3.76742079
39regulation of prostaglandin secretion (GO:0032306)3.72576818
40regulation of interleukin-2 biosynthetic process (GO:0045076)3.72104221
41thymic T cell selection (GO:0045061)3.71985744
42regulation of chronic inflammatory response (GO:0002676)3.69479884
43negative thymic T cell selection (GO:0045060)3.69185619
44alpha-beta T cell activation involved in immune response (GO:0002287)3.68579075
45T cell differentiation involved in immune response (GO:0002292)3.68579075
46alpha-beta T cell differentiation involved in immune response (GO:0002293)3.68579075
47regulation of interleukin-12 biosynthetic process (GO:0045075)3.68386389
48positive regulation of natural killer cell mediated immunity (GO:0002717)3.66698006
49mammary gland epithelial cell proliferation (GO:0033598)3.59452381
50regulation of heat generation (GO:0031650)3.58935248
51negative T cell selection (GO:0043383)3.58750843
52negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.58611190
53positive regulation of bone resorption (GO:0045780)3.57829519
54positive regulation of bone remodeling (GO:0046852)3.57829519
55regulation of T cell receptor signaling pathway (GO:0050856)3.56094846
56negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.55953774
57regulation of receptor recycling (GO:0001919)3.55880153
58positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.50938470
59T cell selection (GO:0045058)3.50200878
60negative regulation of inclusion body assembly (GO:0090084)3.48130780
61activated T cell proliferation (GO:0050798)3.41399212
62positive regulation of defense response to virus by host (GO:0002230)3.39374284
63positive regulation of DNA recombination (GO:0045911)3.38200798
64regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.36639168
65regulation of hypersensitivity (GO:0002883)3.36272580
66positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.34791962
67negative regulation of T-helper cell differentiation (GO:0045623)3.34543872
68negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.34543872
69regulation of T cell mediated cytotoxicity (GO:0001914)3.31139121
70regulation of type B pancreatic cell apoptotic process (GO:2000674)3.30179114
71positive regulation of natural killer cell differentiation (GO:0032825)3.29449072
72JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.29309991
73fusion of sperm to egg plasma membrane (GO:0007342)3.28166394
74very-low-density lipoprotein particle assembly (GO:0034379)3.27259018
75alpha-beta T cell differentiation (GO:0046632)3.26752034
76lymphocyte chemotaxis (GO:0048247)3.26693443
77regulation of chemokine biosynthetic process (GO:0045073)3.26379894
78positive regulation of T cell mediated cytotoxicity (GO:0001916)3.26024705
79negative regulation of cAMP-mediated signaling (GO:0043951)3.25952489
80positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)3.24943181
81positive regulation of receptor recycling (GO:0001921)3.23945340
82positive regulation of isotype switching (GO:0045830)3.23727687
83T cell migration (GO:0072678)3.22652011
84regulation of gamma-delta T cell differentiation (GO:0045586)3.22489368
85positive regulation of B cell mediated immunity (GO:0002714)3.22248443
86positive regulation of immunoglobulin mediated immune response (GO:0002891)3.22248443
87negative regulation of bone resorption (GO:0045779)3.16317985
88CD4-positive, alpha-beta T cell differentiation (GO:0043367)3.16064217
89regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.15094114
90positive regulation of interleukin-17 production (GO:0032740)3.14110099
91positive regulation of gamma-delta T cell activation (GO:0046645)3.13579387
92T cell receptor signaling pathway (GO:0050852)3.12193530
93regulation of gamma-delta T cell activation (GO:0046643)3.11298519
94regulation of regulatory T cell differentiation (GO:0045589)3.09928789
95T cell activation involved in immune response (GO:0002286)3.09690539
96regulation of vitamin metabolic process (GO:0030656)3.08781961
97regulation of T-helper 1 type immune response (GO:0002825)3.08254933
98positive regulation of tyrosine phosphorylation of Stat5 protein (GO:0042523)3.06604366
99negative regulation by host of viral transcription (GO:0043922)3.06426404
100cellular response to nicotine (GO:0071316)3.06190276
101regulation of immunoglobulin production (GO:0002637)3.05617432
102protein neddylation (GO:0045116)3.05202879
103embryonic process involved in female pregnancy (GO:0060136)3.04953756
104positive regulation of interleukin-10 production (GO:0032733)3.04561444
105monocyte chemotaxis (GO:0002548)3.04305965
106alpha-beta T cell activation (GO:0046631)3.04257342
107positive regulation of immunoglobulin production (GO:0002639)3.04148367
108positive regulation of leukocyte mediated cytotoxicity (GO:0001912)3.04040205
109regulation of lymphocyte chemotaxis (GO:1901623)3.03147122
110regulation of mononuclear cell migration (GO:0071675)3.02148689
111positive regulation of interleukin-12 production (GO:0032735)3.01903237
112positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.01635798
113negative regulation of alpha-beta T cell activation (GO:0046636)2.98935923
114negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.98414781
115negative regulation of cytokine production involved in immune response (GO:0002719)2.97904092
116negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.96649923
117regulation of tyrosine phosphorylation of Stat1 protein (GO:0042510)2.95525490
118mammary gland alveolus development (GO:0060749)2.94751919
119positive regulation of cell killing (GO:0031343)2.94493240
120regulation of B cell receptor signaling pathway (GO:0050855)2.93904915
121regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.91864027
122regulation of natural killer cell mediated immunity (GO:0002715)2.91864027
123negative regulation of viral genome replication (GO:0045071)2.91353984
124cellular defense response (GO:0006968)2.91302136
125signal peptide processing (GO:0006465)2.90565024
126regulation of leukocyte mediated cytotoxicity (GO:0001910)2.89902606
127eosinophil chemotaxis (GO:0048245)2.89485526
128positive regulation of icosanoid secretion (GO:0032305)2.89070466
129regulation of T cell tolerance induction (GO:0002664)2.88997527
130positive regulation of alpha-beta T cell proliferation (GO:0046641)2.87609998
131production of molecular mediator involved in inflammatory response (GO:0002532)2.86018261
132regulation of isotype switching (GO:0045191)2.85811271
133tumor necrosis factor-mediated signaling pathway (GO:0033209)2.83662902
134regulation of alpha-beta T cell proliferation (GO:0046640)2.83616143
135negative regulation of T cell mediated immunity (GO:0002710)2.83421673
136regulation of defense response to virus by host (GO:0050691)2.83400611
137myeloid dendritic cell differentiation (GO:0043011)2.83200879
138defense response to protozoan (GO:0042832)2.83103285
139negative regulation of B cell activation (GO:0050869)2.82998707
140CD4-positive, alpha-beta T cell activation (GO:0035710)2.82488505
141negative regulation of interleukin-12 production (GO:0032695)2.81327072
142mature B cell differentiation involved in immune response (GO:0002313)2.81219597
143T cell costimulation (GO:0031295)2.80388662
144positive regulation of interleukin-2 production (GO:0032743)2.79769494
145positive regulation of protein homooligomerization (GO:0032464)2.79449728
146positive regulation of lymphocyte mediated immunity (GO:0002708)2.78713174
147growth hormone receptor signaling pathway (GO:0060396)2.78240064
148lymphocyte costimulation (GO:0031294)2.78128131
149positive regulation of T-helper cell differentiation (GO:0045624)2.78004861
150positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)2.77529369
151chemokine-mediated signaling pathway (GO:0070098)2.77298424
152G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.76874386
153regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)2.75316085
154negative regulation of adaptive immune response (GO:0002820)2.73632558
155neutrophil activation involved in immune response (GO:0002283)2.73088510
156antigen receptor-mediated signaling pathway (GO:0050851)2.72929380
157negative regulation of nitric oxide biosynthetic process (GO:0045019)2.72492802
158regulation of cell killing (GO:0031341)2.72346461
159negative regulation of production of molecular mediator of immune response (GO:0002701)2.72002401
160positive regulation of acute inflammatory response (GO:0002675)2.71816475
161mature B cell differentiation (GO:0002335)2.70624901
162proteasome assembly (GO:0043248)2.70101618
163response to corticosterone (GO:0051412)2.69543962
164positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.67801139
165regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.67801139
166regulation of MHC class II biosynthetic process (GO:0045346)2.66558657
167positive regulation of lymphocyte migration (GO:2000403)2.65623937
168regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)2.64592928
169regulation of immunoglobulin mediated immune response (GO:0002889)2.60428640
170positive regulation of tolerance induction (GO:0002645)2.59876099
171positive regulation of T cell chemotaxis (GO:0010820)2.57390475
172regulation of T cell chemotaxis (GO:0010819)2.57390475

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.71484478
2* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human4.87280599
3STAT3_20064451_ChIP-Seq_CD4+T_Mouse4.03445398
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.36854005
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.26026758
6FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.24871819
7GABP_17652178_ChIP-ChIP_JURKAT_Human3.06310607
8TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.82409559
9BP1_19119308_ChIP-ChIP_Hs578T_Human2.77387850
10FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.74568908
11STAT4_19710469_ChIP-ChIP_TH1__Mouse2.71411427
12RUNX_20019798_ChIP-Seq_JUKART_Human2.64072286
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.61112323
14EST1_17652178_ChIP-ChIP_JURKAT_Human2.56038437
15* IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.55061788
16RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.47290145
17NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.47091418
18IRF8_21731497_ChIP-ChIP_J774_Mouse2.36655600
19* IRF8_27001747_Chip-Seq_BMDM_Mouse2.35075856
20SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.30797384
21SMAD_19615063_ChIP-ChIP_OVARY_Human2.24829292
22* VDR_23849224_ChIP-Seq_CD4+_Human2.23537990
23VDR_22108803_ChIP-Seq_LS180_Human2.21523291
24ELF1_17652178_ChIP-ChIP_JURKAT_Human2.15560815
25IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.09486292
26STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.08873872
27* MYB_26560356_Chip-Seq_TH2_Human2.06934154
28ELK1_19687146_ChIP-ChIP_HELA_Human2.06196294
29* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.05649601
30Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.94773369
31NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.92647233
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.86631113
33HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.82906013
34NOTCH1_21737748_ChIP-Seq_TLL_Human1.75876877
35GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.74791445
36PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.74555941
37FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.72274536
38IGF1R_20145208_ChIP-Seq_DFB_Human1.63764841
39VDR_24787735_ChIP-Seq_THP-1_Human1.61243617
40* CREB1_15753290_ChIP-ChIP_HEK293T_Human1.60382504
41MYB_26560356_Chip-Seq_TH1_Human1.58545512
42LXR_22158963_ChIP-Seq_LIVER_Mouse1.58225722
43FLI1_27457419_Chip-Seq_LIVER_Mouse1.54193284
44BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.53065848
45HOXB4_20404135_ChIP-ChIP_EML_Mouse1.52855406
46ETS1_20019798_ChIP-Seq_JURKAT_Human1.52069838
47ZNF217_24962896_ChIP-Seq_MCF-7_Human1.50412130
48RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.49771974
49* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.49103697
50ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.48851486
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.47316885
52* FOXP3_21729870_ChIP-Seq_TREG_Human1.47115630
53WT1_19549856_ChIP-ChIP_CCG9911_Human1.46926203
54TAF15_26573619_Chip-Seq_HEK293_Human1.43852584
55* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.42756304
56GATA3_27048872_Chip-Seq_THYMUS_Human1.41991145
57MYB_21317192_ChIP-Seq_ERMYB_Mouse1.37381282
58EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.36008456
59RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.33058134
60SCL_19346495_ChIP-Seq_HPC-7_Human1.30652457
61PCGF2_27294783_Chip-Seq_NPCs_Mouse1.29686628
62ZFP57_27257070_Chip-Seq_ESCs_Mouse1.27488682
63PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27276898
64EGR1_23403033_ChIP-Seq_LIVER_Mouse1.27202768
65IRF1_19129219_ChIP-ChIP_H3396_Human1.27106649
66* POU3F2_20337985_ChIP-ChIP_501MEL_Human1.26811518
67NFE2_27457419_Chip-Seq_LIVER_Mouse1.25031252
68PU_27001747_Chip-Seq_BMDM_Mouse1.24964206
69CLOCK_20551151_ChIP-Seq_293T_Human1.24451773
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.21592921
71CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.17281565
72RXR_22158963_ChIP-Seq_LIVER_Mouse1.16230232
73EWS_26573619_Chip-Seq_HEK293_Human1.15329280
74PCGF2_27294783_Chip-Seq_ESCs_Mouse1.15161797
75GATA3_26560356_Chip-Seq_TH2_Human1.14847029
76CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.11924045
77LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11309962
78CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.09014428
79JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.09012820
80NANOG_19829295_ChIP-Seq_ESCs_Human1.07431246
81SOX2_19829295_ChIP-Seq_ESCs_Human1.07431246
82* MAF_26560356_Chip-Seq_TH1_Human1.06565546
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.05891467
84EZH2_27294783_Chip-Seq_NPCs_Mouse1.05356056
85CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.05197991
86CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03993511
87TP53_22573176_ChIP-Seq_HFKS_Human1.03785956
88RUNX1_22412390_ChIP-Seq_EML_Mouse1.03613348
89STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.03477732
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.02856736
91PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.01192368
92PPARA_22158963_ChIP-Seq_LIVER_Mouse1.00650212
93FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.00144134
94HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.99450320
95* BCAT_22108803_ChIP-Seq_LS180_Human0.99251078
96BRD4_27068464_Chip-Seq_AML-cells_Mouse0.99135361
97MYC_18940864_ChIP-ChIP_HL60_Human0.98768032
98SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.96941980
99SUZ12_27294783_Chip-Seq_NPCs_Mouse0.96393957
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.96372177
101RBPJ_21746931_ChIP-Seq_IB4_Human0.96098448
102FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.95411587
103NR3C1_23031785_ChIP-Seq_PC12_Mouse0.93747300
104* CDX2_21074721_ChIP-Seq_CACO-2_Mouse0.92804283
105P300_19829295_ChIP-Seq_ESCs_Human0.91638376
106SMAD4_21799915_ChIP-Seq_A2780_Human0.91443454
107HIF1A_21447827_ChIP-Seq_MCF-7_Human0.91404237
108GATA2_21666600_ChIP-Seq_HMVEC_Human0.91275425
109GATA6_21074721_ChIP-Seq_CACO-2_Mouse0.91050374
110ER_23166858_ChIP-Seq_MCF-7_Human0.90961709
111ESR1_21235772_ChIP-Seq_MCF-7_Human0.90633242
112JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.90552714
113TCF7_22412390_ChIP-Seq_EML_Mouse0.90249582
114GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.90141247
115* PHF8_20622853_ChIP-Seq_HELA_Human0.89951951
116PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.89926439
117CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89527140
118GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.89511038
119AHR_22903824_ChIP-Seq_MCF-7_Human0.89276826
120SRF_21415370_ChIP-Seq_HL-1_Mouse0.89162684
121RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.88830665
122* GATA6_21074721_ChIP-Seq_CACO-2_Human0.88632422
123SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.88606429
124FOXO3_23340844_ChIP-Seq_DLD1_Human0.88157832
125* SALL4_22934838_ChIP-ChIP_CD34+_Human0.87767559
126* ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.86811725
127MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.86498960
128CRX_20693478_ChIP-Seq_RETINA_Mouse0.86318092
129AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86297878
130* SMRT_27268052_Chip-Seq_Bcells_Human0.85615095
131PADI4_21655091_ChIP-ChIP_MCF-7_Human0.85405964
132CJUN_26792858_Chip-Seq_BT549_Human0.85049767
133NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.84696042
134DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.83140835
135MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.82735971
136LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.82192996
137* GATA3_26560356_Chip-Seq_TH1_Human0.82066296
138VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.81475328
139TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.81422826
140FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.81055024
141TP53_18474530_ChIP-ChIP_U2OS_Human0.80580143
142OCT4_21477851_ChIP-Seq_ESCs_Mouse0.80316133
143* HNFA_21074721_ChIP-Seq_CACO-2_Human0.79648669
144TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.79580105
145ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.79485592
146TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.79382397
147ELK1_22589737_ChIP-Seq_MCF10A_Human0.79116027
148CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse0.79029559
149PIAS1_25552417_ChIP-Seq_VCAP_Human0.78644713
150NANOG_18555785_Chip-Seq_ESCs_Mouse0.78258554
151HTT_18923047_ChIP-ChIP_STHdh_Human0.78137203
152ZNF274_21170338_ChIP-Seq_K562_Hela0.78028604
153SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77359918
154NMYC_18555785_Chip-Seq_ESCs_Mouse0.76746708
155MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.76282569
156CBP_20019798_ChIP-Seq_JUKART_Human0.76191645
157IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.76191645
158GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.75907552

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002138_abnormal_hepatobiliary_system3.73093726
2MP0003724_increased_susceptibility_to3.39286346
3MP0005671_abnormal_response_to3.34127532
4MP0000685_abnormal_immune_system3.21051118
5MP0005387_immune_system_phenotype3.18255950
6MP0001790_abnormal_immune_system3.18255950
7MP0005000_abnormal_immune_tolerance2.97946596
8MP0001835_abnormal_antigen_presentation2.91196162
9MP0003763_abnormal_thymus_physiology2.89867338
10MP0009785_altered_susceptibility_to2.82409231
11MP0003303_peritoneal_inflammation2.77113172
12MP0001800_abnormal_humoral_immune2.73685043
13MP0002163_abnormal_gland_morphology2.60164917
14MP0002148_abnormal_hypersensitivity_rea2.58860248
15MP0003300_gastrointestinal_ulcer2.52995131
16MP0004510_myositis2.50702769
17MP0002723_abnormal_immune_serum2.49501896
18MP0003436_decreased_susceptibility_to2.41685231
19MP0002452_abnormal_antigen_presenting2.24130224
20MP0002405_respiratory_system_inflammati2.22955214
21MP0004947_skin_inflammation2.17877271
22MP0005025_abnormal_response_to2.09150728
23MP0001819_abnormal_immune_cell2.08018702
24MP0002420_abnormal_adaptive_immunity2.06458701
25MP0006082_CNS_inflammation1.98785632
26MP0002277_abnormal_respiratory_mucosa1.96485661
27MP0005379_endocrine/exocrine_gland_phen1.93351340
28MP0001853_heart_inflammation1.92508001
29MP0002419_abnormal_innate_immunity1.91551097
30MP0001873_stomach_inflammation1.81138023
31MP0010155_abnormal_intestine_physiology1.80784630
32MP0002009_preneoplasia1.80653397
33MP0001851_eye_inflammation1.78027559
34MP0002166_altered_tumor_susceptibility1.77512668
35MP0005410_abnormal_fertilization1.72394027
36MP0005310_abnormal_salivary_gland1.71850164
37MP0001845_abnormal_inflammatory_respons1.70019686
38MP0003866_abnormal_defecation1.66133004
39MP0001881_abnormal_mammary_gland1.60876813
40MP0002398_abnormal_bone_marrow1.59911313
41MP0000716_abnormal_immune_system1.56777458
42MP0002837_dystrophic_cardiac_calcinosis1.54568779
43MP0002877_abnormal_melanocyte_morpholog1.53494241
44MP0002006_tumorigenesis1.48839349
45MP0009333_abnormal_splenocyte_physiolog1.44460591
46MP0001533_abnormal_skeleton_physiology1.37976143
47MP0001348_abnormal_lacrimal_gland1.36062170
48MP0003186_abnormal_redox_activity1.35527843
49MP0000703_abnormal_thymus_morphology1.34926850
50MP0003646_muscle_fatigue1.34522428
51MP0004883_abnormal_blood_vessel1.31798489
52MP0002722_abnormal_immune_system1.30891177
53MP0003950_abnormal_plasma_membrane1.30248389
54MP0000249_abnormal_blood_vessel1.29636631
55MP0002998_abnormal_bone_remodeling1.28977968
56MP0000689_abnormal_spleen_morphology1.28291538
57MP0002933_joint_inflammation1.26685502
58MP0003195_calcinosis1.25889387
59MP0008469_abnormal_protein_level1.24537311
60MP0009764_decreased_sensitivity_to1.24304140
61MP0002928_abnormal_bile_duct1.22877914
62MP0005365_abnormal_bile_salt1.22481375
63MP0003448_altered_tumor_morphology1.21268376
64MP0002132_abnormal_respiratory_system1.20500818
65MP0002693_abnormal_pancreas_physiology1.20187349
66MP0005464_abnormal_platelet_physiology1.18290854
67MP0009840_abnormal_foam_cell1.16050446
68MP0002429_abnormal_blood_cell1.12484909
69MP0004215_abnormal_myocardial_fiber1.11854020
70MP0002254_reproductive_system_inflammat1.10390452
71MP0008058_abnormal_DNA_repair1.09923657
72MP0001542_abnormal_bone_strength1.08517867
73MP0003252_abnormal_bile_duct1.08012806
74MP0005164_abnormal_response_to1.06413603
75MP0001501_abnormal_sleep_pattern1.05769830
76MP0001919_abnormal_reproductive_system1.05669497
77MP0006036_abnormal_mitochondrial_physio1.04680954
78MP0003638_abnormal_response/metabolism_1.04167306
79* MP0000609_abnormal_liver_physiology1.02558425
80MP0002653_abnormal_ependyma_morphology1.01732031
81MP0000343_altered_response_to1.01650195
82MP0008004_abnormal_stomach_pH1.00021340
83MP0002638_abnormal_pupillary_reflex0.93299344
84MP0000372_irregular_coat_pigmentation0.91811420
85MP0004264_abnormal_extraembryonic_tissu0.91766867
86MP0005253_abnormal_eye_physiology0.90312157
87MP0004742_abnormal_vestibular_system0.89788312
88MP0003091_abnormal_cell_migration0.89678518
89MP0009763_increased_sensitivity_to0.89373885
90MP0000858_altered_metastatic_potential0.88772780
91MP0008872_abnormal_physiological_respon0.87924836
92MP0000465_gastrointestinal_hemorrhage0.87680257
93MP0005647_abnormal_sex_gland0.87334132
94MP0006072_abnormal_retinal_apoptosis0.86547329
95MP0008961_abnormal_basal_metabolism0.85851901
96MP0004381_abnormal_hair_follicle0.85677857
97MP0004019_abnormal_vitamin_homeostasis0.85549445
98MP0002876_abnormal_thyroid_physiology0.85395073
99MP0009765_abnormal_xenobiotic_induced0.84788141
100MP0001879_abnormal_lymphatic_vessel0.84118427
101MP0008995_early_reproductive_senescence0.83816530
102MP0002736_abnormal_nociception_after0.82801027
103MP0002136_abnormal_kidney_physiology0.82042396
104MP0003787_abnormal_imprinting0.80966712
105MP0010329_abnormal_lipoprotein_level0.79715018
106MP0008875_abnormal_xenobiotic_pharmacok0.78713406
107MP0002090_abnormal_vision0.77929034
108MP0005165_increased_susceptibility_to0.77426485
109MP0001663_abnormal_digestive_system0.76731387
110MP0000627_abnormal_mammary_gland0.75750696
111MP0005166_decreased_susceptibility_to0.75666562
112MP0003045_fibrosis0.73629031
113MP0000604_amyloidosis0.72745646
114MP0002139_abnormal_hepatobiliary_system0.71881695
115MP0005360_urolithiasis0.70863744
116MP0005551_abnormal_eye_electrophysiolog0.70159784
117MP0005451_abnormal_body_composition0.69214994
118MP0004145_abnormal_muscle_electrophysio0.69178362
119MP0002332_abnormal_exercise_endurance0.68943669
120MP0005390_skeleton_phenotype0.68663022
121MP0008877_abnormal_DNA_methylation0.67398345
122MP0005167_abnormal_blood-brain_barrier0.66271184
123MP0001764_abnormal_homeostasis0.65740188
124MP0005535_abnormal_body_temperature0.65583804
125MP0000013_abnormal_adipose_tissue0.65300851
126MP0000490_abnormal_crypts_of0.64266627
127MP0008873_increased_physiological_sensi0.63758642
128MP0008057_abnormal_DNA_replication0.62929124
129MP0001243_abnormal_dermal_layer0.61872537
130MP0005085_abnormal_gallbladder_physiolo0.61571731
131MP0003011_delayed_dark_adaptation0.61440406
132MP0003795_abnormal_bone_structure0.61386639
133MP0001346_abnormal_lacrimal_gland0.60721933
134MP0005084_abnormal_gallbladder_morpholo0.60125600
135MP0004142_abnormal_muscle_tone0.59757007

Predicted human phenotypes

RankGene SetZ-score
1Retrobulbar optic neuritis (HP:0100654)8.50188494
2Optic neuritis (HP:0100653)8.50188494
3Orchitis (HP:0100796)7.60450986
4Myositis (HP:0100614)7.02397289
5Stomatitis (HP:0010280)6.69241253
6Autoimmune hemolytic anemia (HP:0001890)5.76900896
7Keratoconjunctivitis sicca (HP:0001097)5.76165743
8Keratoconjunctivitis (HP:0001096)5.21592843
9Increased density of long bones (HP:0006392)4.72769744
10Pulmonary infiltrates (HP:0002113)4.56932717
11Persistence of primary teeth (HP:0006335)4.45740443
12Rhinitis (HP:0012384)4.42479217
13Arterial thrombosis (HP:0004420)4.42150482
14Elevated erythrocyte sedimentation rate (HP:0003565)4.16593389
15Vasculitis (HP:0002633)3.77776357
163-Methylglutaconic aciduria (HP:0003535)3.57465428
17Acute necrotizing encephalopathy (HP:0006965)3.54166662
18IgM deficiency (HP:0002850)3.46132773
19Pulmonary embolism (HP:0002204)3.44858711
20Gangrene (HP:0100758)3.41990491
21Nasal polyposis (HP:0100582)3.38529352
22Hemoptysis (HP:0002105)3.35439973
23Eczematoid dermatitis (HP:0000976)3.08970113
24Gastrointestinal infarctions (HP:0005244)3.08343165
25Joint swelling (HP:0001386)3.03181376
26Mitochondrial inheritance (HP:0001427)3.00496985
27Abnormal mitochondria in muscle tissue (HP:0008316)3.00383830
28Abnormality of the nasal mucosa (HP:0000433)2.97757868
29Absent/shortened dynein arms (HP:0200106)2.95931307
30Dynein arm defect of respiratory motile cilia (HP:0012255)2.95931307
31Progressive macrocephaly (HP:0004481)2.95856935
32Anorexia (HP:0002039)2.92858691
33Increased CSF lactate (HP:0002490)2.92443433
34Abnormality of T cell number (HP:0011839)2.91292339
35Increased IgM level (HP:0003496)2.89987052
36Alveolar cell carcinoma (HP:0006519)2.89877866
37Encephalitis (HP:0002383)2.88505973
38Recurrent bronchitis (HP:0002837)2.84149824
39Glomerulopathy (HP:0100820)2.82361702
40Acute encephalopathy (HP:0006846)2.81682178
41Thrombophlebitis (HP:0004418)2.78663162
42Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.77673407
43Thyroiditis (HP:0100646)2.77524632
44Dyschromatopsia (HP:0007641)2.75594144
45IgG deficiency (HP:0004315)2.75044495
46Increased neuronal autofluorescent lipopigment (HP:0002074)2.73917737
47Autoimmune thrombocytopenia (HP:0001973)2.72819187
48Meningitis (HP:0001287)2.71592975
49Mediastinal lymphadenopathy (HP:0100721)2.70686351
50Abnormality of midbrain morphology (HP:0002418)2.70087203
51Molar tooth sign on MRI (HP:0002419)2.70087203
52Severe combined immunodeficiency (HP:0004430)2.68763736
53Abnormal pupillary function (HP:0007686)2.68293077
54Abnormality of eosinophils (HP:0001879)2.64193670
55Premature loss of primary teeth (HP:0006323)2.59468040
56Parakeratosis (HP:0001036)2.58720765
57Abnormality of the prostate (HP:0008775)2.52777829
58Pancreatic cysts (HP:0001737)2.50445767
59B lymphocytopenia (HP:0010976)2.49177033
60Abnormality of B cell number (HP:0010975)2.49177033
61Congenital stationary night blindness (HP:0007642)2.48427761
62Neoplasm of the tracheobronchial system (HP:0100552)2.47608615
63Recurrent sinusitis (HP:0011108)2.47457390
64Increased cerebral lipofuscin (HP:0011813)2.45317737
65Increased hepatocellular lipid droplets (HP:0006565)2.44620308
66T lymphocytopenia (HP:0005403)2.41175863
67Nausea (HP:0002018)2.40291685
68Keratitis (HP:0000491)2.39944388
69Hypoproteinemia (HP:0003075)2.38349486
70Tetraparesis (HP:0002273)2.37866611
71Exertional dyspnea (HP:0002875)2.35264373
72Eosinophilia (HP:0001880)2.33209879
73Polyneuropathy (HP:0001271)2.28400145
74IgA deficiency (HP:0002720)2.27895712
75Pancreatitis (HP:0001733)2.27418394
76Testicular atrophy (HP:0000029)2.27287884
77Abnormality of the pericardium (HP:0001697)2.26885843
78Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.26770058
79Congenital, generalized hypertrichosis (HP:0004540)2.25904305
80Aplastic anemia (HP:0001915)2.25825702
81Paralysis (HP:0003470)2.25450027
82Lipid accumulation in hepatocytes (HP:0006561)2.22842373
83Bronchitis (HP:0012387)2.22802081
84Abnormality of T cells (HP:0002843)2.20808169
85Recurrent fungal infections (HP:0002841)2.20435317
86Prostate neoplasm (HP:0100787)2.17395563
87Myocardial infarction (HP:0001658)2.17139372
88Recurrent gram-negative bacterial infections (HP:0005420)2.15730735
89Cerebral edema (HP:0002181)2.15572276
90Gastrointestinal stroma tumor (HP:0100723)2.14873365
91Abnormality of the renal cortex (HP:0011035)2.13585296
92Renal Fanconi syndrome (HP:0001994)2.12400715
93Abnormal respiratory motile cilium physiology (HP:0012261)2.12286720
94Hepatocellular necrosis (HP:0001404)2.10873708
95Vacuolated lymphocytes (HP:0001922)2.10356951
96Chronic diarrhea (HP:0002028)2.08983327
97Combined immunodeficiency (HP:0005387)2.08870767
98Pancreatic fibrosis (HP:0100732)2.05977951
99Leukocytosis (HP:0001974)2.01892864
100Abnormal respiratory epithelium morphology (HP:0012253)2.01387827
101Abnormal respiratory motile cilium morphology (HP:0005938)2.01387827
102Muscle fiber atrophy (HP:0100295)2.01217997
103Bronchiectasis (HP:0002110)2.01166991
104Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99309385
105Abnormality of alanine metabolism (HP:0010916)1.98904625
106Hyperalaninemia (HP:0003348)1.98904625
107Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.98904625
108Increased serum lactate (HP:0002151)1.98737434
109Abnormality of T cell physiology (HP:0011840)1.96004733
110Abnormality of the pleura (HP:0002103)1.95997103
111Vertigo (HP:0002321)1.95147587
112Osteomyelitis (HP:0002754)1.94916282
113Central scotoma (HP:0000603)1.93415572
114Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.92980521
115Optic disc pallor (HP:0000543)1.92701874
116Decreased activity of mitochondrial respiratory chain (HP:0008972)1.91951445
117Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.91951445
118Arthralgia (HP:0002829)1.91211664
119Cerebral hemorrhage (HP:0001342)1.90466056
120Gingival bleeding (HP:0000225)1.89761383
121Abnormal ciliary motility (HP:0012262)1.87928358
122Recurrent bacterial skin infections (HP:0005406)1.87753299
123Spontaneous hematomas (HP:0007420)1.87335763
124Abnormality of the common coagulation pathway (HP:0010990)1.85136386
125Hypergammaglobulinemia (HP:0010702)1.84690998
126Recurrent viral infections (HP:0004429)1.84542273
127Bile duct proliferation (HP:0001408)1.83753205
128Abnormal biliary tract physiology (HP:0012439)1.83753205
129Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.82334357
130Hepatic necrosis (HP:0002605)1.81122986
131Lactic acidosis (HP:0003128)1.80937181
132Recurrent cutaneous fungal infections (HP:0011370)1.80669370
133Chronic mucocutaneous candidiasis (HP:0002728)1.80669370
134Interstitial pulmonary disease (HP:0006530)1.80190670
135Abnormality of cells of the lymphoid lineage (HP:0012140)1.80096334
136Hypokalemic alkalosis (HP:0001949)1.78806931
137Acne (HP:0001061)1.78682040
138Anhidrosis (HP:0000970)1.78158904
139Fair hair (HP:0002286)1.77951709
140Abnormality of binocular vision (HP:0011514)1.76657802
141Diplopia (HP:0000651)1.76657802
142Abnormal delayed hypersensitivity skin test (HP:0002963)1.75383152
143Prolonged partial thromboplastin time (HP:0003645)1.74046149
144Increased intramyocellular lipid droplets (HP:0012240)1.73346942
145Abnormal spermatogenesis (HP:0008669)1.72680273
146Mitral stenosis (HP:0001718)1.71874516
147Neutropenia (HP:0001875)1.70351519
148Lymphopenia (HP:0001888)1.70168959
149Rimmed vacuoles (HP:0003805)1.69122095
150Upper limb muscle weakness (HP:0003484)1.68979466
151Short tibia (HP:0005736)1.68921063
152Granulocytopenia (HP:0001913)1.68876876
153Abnormality of aromatic amino acid family metabolism (HP:0004338)1.67716624
154Recurrent abscess formation (HP:0002722)1.64389838
155Hyperventilation (HP:0002883)1.63443930
156Azoospermia (HP:0000027)1.61591142

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TXK5.52080164
2MAP3K144.37737661
3TAOK34.28371141
4IRAK33.86420257
5TBK12.77203752
6ITK2.53547575
7MAP4K12.48689162
8IKBKB2.31966368
9TEC2.30776412
10EIF2AK32.21438124
11MAPK152.21265409
12JAK12.17968242
13MST42.13747558
14IKBKE2.04949276
15EPHA32.01302404
16CHUK1.95439562
17TSSK61.93547929
18PNCK1.83599526
19BRD41.82057064
20FGFR41.67442262
21ZAK1.60173684
22BUB11.57287696
23IRAK11.56387444
24GRK61.56264841
25ZAP701.55504996
26PIM11.55464079
27EPHB11.54478045
28TRIM281.51784312
29FGFR31.45871815
30JAK31.43826843
31BMPR21.42613315
32TYK21.38205766
33MAP3K111.34152681
34EIF2AK11.30731184
35PDK41.29865332
36PDK31.29865332
37SYK1.19438407
38BTK1.17770811
39MAP2K61.17289972
40SIK31.16652971
41NLK1.14907283
42PDK21.10937536
43CAMKK21.09657828
44HCK1.06997699
45RIPK41.06782131
46LCK1.04085387
47PBK1.04022185
48MAP2K31.03639005
49CDK30.99452313
50TGFBR20.99336607
51IRAK40.98660208
52WEE10.95632777
53CASK0.92870887
54BCR0.91249831
55VRK10.90660079
56GRK10.88645552
57PIM20.88487919
58ACVR1B0.88206694
59STK160.88103296
60MKNK20.87813621
61DYRK1B0.87674010
62SRPK10.86987157
63TYRO30.86415582
64TAOK20.85856598
65PAK30.85027228
66NEK10.84640439
67RIPK10.83843790
68MAP3K120.83603309
69TLK10.82845287
70MAP3K30.82593503
71JAK20.81865600
72NME20.81370192
73AKT30.81130109
74PTK2B0.80851014
75STK390.80353384
76PRKCQ0.77311041
77MATK0.76121890
78KDR0.72988163
79BRSK20.72169603
80OBSCN0.71362606
81FES0.70437656
82CCNB10.69560548
83NEK90.68471196
84CSK0.68459168
85PIK3CA0.68149557
86GRK70.65400173
87HIPK20.65062581
88MAPKAPK30.64672096
89MAP3K130.63209626
90ERBB30.62587250
91IGF1R0.61469798
92DAPK20.60494058
93FER0.60241897
94CLK10.60218869
95WNK30.58433838
96MAPK70.57496646
97MARK30.57304470
98CDK60.57125487
99LYN0.55440363
100CDK40.53937551
101ABL20.53862007
102MAP3K50.53200580
103KIT0.53135510
104MAP4K20.52954603
105STK240.52931130
106EPHB20.50762323
107BMPR1B0.48634139
108BMX0.48012494
109OXSR10.47844806
110INSRR0.47390615
111MYLK0.47155542
112CDK90.46839049
113PRKCE0.46760123
114TNK20.46435368
115TIE10.45441699
116MAPKAPK50.45051564
117MOS0.43068636
118RPS6KA50.42829528
119MAPK40.39544382
120NUAK10.39509185
121PIK3CG0.38625171
122MAP3K10.37019015
123INSR0.36713701
124NEK60.36588191
125FRK0.34964878
126SGK30.34431859
127PDGFRB0.34349348
128DYRK30.34228515
129EGFR0.32960430
130PKN10.32591014
131STK38L0.32589142
132SGK20.32582283
133ADRBK10.32185276
134ADRBK20.30412500
135ARAF0.30356544
136EIF2AK20.28823820
137STK100.28279134
138PLK30.26575040
139* CSNK2A10.26209278
140MAPKAPK20.25025568
141ABL10.24897299
142FYN0.24666033
143WNK40.24433567

Predicted pathways (KEGG)

RankGene SetZ-score
1Inflammatory bowel disease (IBD)_Homo sapiens_hsa053214.59113639
2Graft-versus-host disease_Homo sapiens_hsa053323.36063107
3Proteasome_Homo sapiens_hsa030503.18186247
4Allograft rejection_Homo sapiens_hsa053303.06724318
5NF-kappa B signaling pathway_Homo sapiens_hsa040643.06040454
6Primary immunodeficiency_Homo sapiens_hsa053402.91399164
7Osteoclast differentiation_Homo sapiens_hsa043802.71762025
8T cell receptor signaling pathway_Homo sapiens_hsa046602.63741125
9Autoimmune thyroid disease_Homo sapiens_hsa053202.55818122
10Intestinal immune network for IgA production_Homo sapiens_hsa046722.54536012
11Oxidative phosphorylation_Homo sapiens_hsa001902.52641896
12Measles_Homo sapiens_hsa051622.49160002
13Rheumatoid arthritis_Homo sapiens_hsa053232.20031921
14Parkinsons disease_Homo sapiens_hsa050122.08692534
15Circadian rhythm_Homo sapiens_hsa047102.05052352
16TNF signaling pathway_Homo sapiens_hsa046682.00808708
17Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.98092952
18Leishmaniasis_Homo sapiens_hsa051401.94450430
19Staphylococcus aureus infection_Homo sapiens_hsa051501.89775877
20Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.86184827
21Jak-STAT signaling pathway_Homo sapiens_hsa046301.83475239
22Type I diabetes mellitus_Homo sapiens_hsa049401.82559606
23Antigen processing and presentation_Homo sapiens_hsa046121.74276063
24Sulfur metabolism_Homo sapiens_hsa009201.71556805
25Legionellosis_Homo sapiens_hsa051341.70580810
26Hematopoietic cell lineage_Homo sapiens_hsa046401.67794613
27RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.65302371
28NOD-like receptor signaling pathway_Homo sapiens_hsa046211.56041258
29Ribosome_Homo sapiens_hsa030101.49032049
30Basal transcription factors_Homo sapiens_hsa030221.48255747
31Asthma_Homo sapiens_hsa053101.47950930
32Toxoplasmosis_Homo sapiens_hsa051451.44614505
33Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.43198399
34RNA polymerase_Homo sapiens_hsa030201.39794680
35Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.32419068
36B cell receptor signaling pathway_Homo sapiens_hsa046621.28913502
37Huntingtons disease_Homo sapiens_hsa050161.20206046
38RNA degradation_Homo sapiens_hsa030181.19885356
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.18213848
40Alzheimers disease_Homo sapiens_hsa050101.17813798
41Chemokine signaling pathway_Homo sapiens_hsa040621.15606074
42Protein export_Homo sapiens_hsa030601.14674673
43Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.13960544
44Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.13853036
45Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.12796729
46Influenza A_Homo sapiens_hsa051641.11266926
47Regulation of autophagy_Homo sapiens_hsa041401.09435513
48Prolactin signaling pathway_Homo sapiens_hsa049171.08515200
49Malaria_Homo sapiens_hsa051441.07904043
50Complement and coagulation cascades_Homo sapiens_hsa046101.07313425
51Steroid biosynthesis_Homo sapiens_hsa001001.05335175
52African trypanosomiasis_Homo sapiens_hsa051431.04070622
53Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.02324057
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.97036757
55Phototransduction_Homo sapiens_hsa047440.95892955
56Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88142170
57Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.87111303
58Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85739139
59Homologous recombination_Homo sapiens_hsa034400.85639744
60Cardiac muscle contraction_Homo sapiens_hsa042600.85563803
61Pertussis_Homo sapiens_hsa051330.85079215
62Mineral absorption_Homo sapiens_hsa049780.84997092
63Spliceosome_Homo sapiens_hsa030400.81261345
64Shigellosis_Homo sapiens_hsa051310.80156213
65Apoptosis_Homo sapiens_hsa042100.79120760
66Hepatitis B_Homo sapiens_hsa051610.78598153
67Herpes simplex infection_Homo sapiens_hsa051680.78333450
68Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.78183613
69Tuberculosis_Homo sapiens_hsa051520.77386713
70Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.76052295
71Maturity onset diabetes of the young_Homo sapiens_hsa049500.73966613
72Nitrogen metabolism_Homo sapiens_hsa009100.71780981
73Collecting duct acid secretion_Homo sapiens_hsa049660.67984809
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.67961303
75Retinol metabolism_Homo sapiens_hsa008300.67785684
76Primary bile acid biosynthesis_Homo sapiens_hsa001200.67683856
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.67563121
78One carbon pool by folate_Homo sapiens_hsa006700.66343052
79Salmonella infection_Homo sapiens_hsa051320.63194181
80Epstein-Barr virus infection_Homo sapiens_hsa051690.62770618
81AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.62200087
82Hepatitis C_Homo sapiens_hsa051600.61293925
83MAPK signaling pathway_Homo sapiens_hsa040100.59378086
84Renin secretion_Homo sapiens_hsa049240.58238680
85Nucleotide excision repair_Homo sapiens_hsa034200.57991418
86Systemic lupus erythematosus_Homo sapiens_hsa053220.55169730
87Acute myeloid leukemia_Homo sapiens_hsa052210.54274524
88Phagosome_Homo sapiens_hsa041450.53451638
89Cocaine addiction_Homo sapiens_hsa050300.52769367
90SNARE interactions in vesicular transport_Homo sapiens_hsa041300.50052669
91Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.49817096
92Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.48518601
93Insulin resistance_Homo sapiens_hsa049310.47135813
94Amphetamine addiction_Homo sapiens_hsa050310.46362091
95Vitamin B6 metabolism_Homo sapiens_hsa007500.44976536
96Vibrio cholerae infection_Homo sapiens_hsa051100.44636675
97Leukocyte transendothelial migration_Homo sapiens_hsa046700.41464966
98RNA transport_Homo sapiens_hsa030130.41143431
99FoxO signaling pathway_Homo sapiens_hsa040680.39991185
100Folate biosynthesis_Homo sapiens_hsa007900.39945789
101Type II diabetes mellitus_Homo sapiens_hsa049300.39786466
102Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.39484607
103Pyrimidine metabolism_Homo sapiens_hsa002400.39066358
104Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.38771202
105Purine metabolism_Homo sapiens_hsa002300.38452468
106Mismatch repair_Homo sapiens_hsa034300.37949960
107Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.36496089
108Viral myocarditis_Homo sapiens_hsa054160.36039700
109Endocytosis_Homo sapiens_hsa041440.35801061
110Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35340846
111Platelet activation_Homo sapiens_hsa046110.35077113
112Vascular smooth muscle contraction_Homo sapiens_hsa042700.34836645
113HIF-1 signaling pathway_Homo sapiens_hsa040660.34723653
114Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.34087930
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.31988184
116Fanconi anemia pathway_Homo sapiens_hsa034600.31968955
117Cysteine and methionine metabolism_Homo sapiens_hsa002700.31843014
118Viral carcinogenesis_Homo sapiens_hsa052030.29883100
119Peroxisome_Homo sapiens_hsa041460.29835875
120Prion diseases_Homo sapiens_hsa050200.29500472
121Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.29104299
122Histidine metabolism_Homo sapiens_hsa003400.27239514
123Linoleic acid metabolism_Homo sapiens_hsa005910.26604122
124Tryptophan metabolism_Homo sapiens_hsa003800.25547528
125Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24632209
126* HTLV-I infection_Homo sapiens_hsa051660.24608711
127Fat digestion and absorption_Homo sapiens_hsa049750.23966583
128Prostate cancer_Homo sapiens_hsa052150.23640358
129Arginine and proline metabolism_Homo sapiens_hsa003300.23572666
130Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.22436519
131Phenylalanine metabolism_Homo sapiens_hsa003600.22291234
132Inositol phosphate metabolism_Homo sapiens_hsa005620.21687773
133Phosphatidylinositol signaling system_Homo sapiens_hsa040700.21538382
134Lysosome_Homo sapiens_hsa041420.21206416
135Aldosterone synthesis and secretion_Homo sapiens_hsa049250.20706063
136Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.20591920
137Neurotrophin signaling pathway_Homo sapiens_hsa047220.19614616
138Small cell lung cancer_Homo sapiens_hsa052220.19290161
139Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.19179599
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.18285793
141Glucagon signaling pathway_Homo sapiens_hsa049220.18018285
142Glutathione metabolism_Homo sapiens_hsa004800.16531261
143Caffeine metabolism_Homo sapiens_hsa002320.16169134
144cAMP signaling pathway_Homo sapiens_hsa040240.15897897
145Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.15116386

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