CRHBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1adult feeding behavior (GO:0008343)8.87090857
2regulation of neurotransmitter uptake (GO:0051580)8.38734346
3arginine catabolic process (GO:0006527)7.98319442
4negative regulation of calcium ion transport into cytosol (GO:0010523)7.76443701
5endothelium development (GO:0003158)7.35526096
6neurotransmitter biosynthetic process (GO:0042136)7.31862247
7definitive hemopoiesis (GO:0060216)7.26522759
8negative regulation of neurotransmitter transport (GO:0051589)6.96079012
9peptidyl-cysteine modification (GO:0018198)6.77947607
10positive regulation of synaptic transmission, dopaminergic (GO:0032226)6.69003713
11positive regulation of action potential (GO:0045760)6.42165392
12positive regulation of synaptic transmission, GABAergic (GO:0032230)6.37057907
13succinate metabolic process (GO:0006105)6.18552335
14seminiferous tubule development (GO:0072520)6.07851546
15positive regulation of guanylate cyclase activity (GO:0031284)6.00458142
16regulation of response to food (GO:0032095)5.86958010
17positive regulation of uterine smooth muscle contraction (GO:0070474)5.49210980
18regulation of female receptivity (GO:0045924)5.38720720
19regulation of guanylate cyclase activity (GO:0031282)5.38420987
20neurotransmitter metabolic process (GO:0042133)5.27601899
21positive regulation of vasculogenesis (GO:2001214)5.27276219
22arginine metabolic process (GO:0006525)5.25334724
23regulation of dopamine uptake involved in synaptic transmission (GO:0051584)5.16576152
24regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)5.16576152
25female mating behavior (GO:0060180)5.02822847
26glutamine family amino acid catabolic process (GO:0009065)5.01808316
27phagosome maturation (GO:0090382)5.01742245
28regulation of appetite (GO:0032098)4.98503982
29positive regulation of response to extracellular stimulus (GO:0032106)4.97436066
30positive regulation of response to nutrient levels (GO:0032109)4.97436066
31positive regulation of sodium ion transmembrane transport (GO:1902307)4.90245463
32nitric oxide mediated signal transduction (GO:0007263)4.61556570
33regulation of antigen processing and presentation of peptide antigen (GO:0002583)4.60772457
34positive regulation of B cell differentiation (GO:0045579)4.60229421
35positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-4.58487082
36ATP hydrolysis coupled proton transport (GO:0015991)4.55489485
37energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.55489485
38megakaryocyte development (GO:0035855)4.53437203
39urinary tract smooth muscle contraction (GO:0014848)4.51567605
40epithelial cell differentiation involved in kidney development (GO:0035850)4.46517984
41synaptic vesicle exocytosis (GO:0016079)4.46333872
42regulation of uterine smooth muscle contraction (GO:0070472)4.46019772
43thrombin receptor signaling pathway (GO:0070493)4.38080465
44positive regulation of histone acetylation (GO:0035066)4.36034330
45branched-chain amino acid catabolic process (GO:0009083)4.31254870
46hyperosmotic salinity response (GO:0042538)4.30919196
47nitric oxide biosynthetic process (GO:0006809)4.30686853
48positive regulation of cGMP biosynthetic process (GO:0030828)4.28593397
49transferrin transport (GO:0033572)4.27961943
50protein-cofactor linkage (GO:0018065)4.26256506
51maternal behavior (GO:0042711)4.25213062
52drinking behavior (GO:0042756)4.23233621
53pyrimidine deoxyribonucleotide catabolic process (GO:0009223)4.17545136
54branched-chain amino acid metabolic process (GO:0009081)4.14848169
55Rac protein signal transduction (GO:0016601)4.12363058
56tachykinin receptor signaling pathway (GO:0007217)4.11368498
57parental behavior (GO:0060746)4.07607822
58ferric iron transport (GO:0015682)4.05514529
59trivalent inorganic cation transport (GO:0072512)4.05514529
60neurotransmitter secretion (GO:0007269)4.01009105
61regulation of cGMP biosynthetic process (GO:0030826)4.00229844
62relaxation of smooth muscle (GO:0044557)3.93983683
63positive regulation of vascular permeability (GO:0043117)3.92121472
64positive regulation of amino acid transport (GO:0051957)3.91782034
65dicarboxylic acid catabolic process (GO:0043649)3.86338335
66* aggressive behavior (GO:0002118)3.86170310
67positive regulation of protein acetylation (GO:1901985)3.85300770
68positive regulation of peptidyl-lysine acetylation (GO:2000758)3.85300770
69G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.81493164
70regulation of synaptic vesicle exocytosis (GO:2000300)3.79197064
71DNA deamination (GO:0045006)3.78090030
72positive regulation of cGMP metabolic process (GO:0030825)3.75219937
73myoblast fusion (GO:0007520)3.71469108
74negative regulation of synaptic transmission, GABAergic (GO:0032229)3.64066098
75negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.64043643
76cellular response to exogenous dsRNA (GO:0071360)3.63103876
77ionotropic glutamate receptor signaling pathway (GO:0035235)3.62662912
78neuron cell-cell adhesion (GO:0007158)3.62282683
79valine metabolic process (GO:0006573)3.59798103
80interkinetic nuclear migration (GO:0022027)3.59492513
81regulation of action potential (GO:0098900)3.59051042
82positive regulation of sodium ion transport (GO:0010765)3.58892416
83immunoglobulin mediated immune response (GO:0016064)3.57586731
84positive regulation of neurotransmitter transport (GO:0051590)3.57108807
85regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.56100594
86regulation of synaptic transmission, GABAergic (GO:0032228)3.55411189
87regulation of vasculogenesis (GO:2001212)3.54550436
88inositol metabolic process (GO:0006020)3.54477326
89vocalization behavior (GO:0071625)3.54407064
90negative regulation of potassium ion transport (GO:0043267)3.53887860
91positive regulation of amine transport (GO:0051954)3.53414535
92regulation of neurotransmitter levels (GO:0001505)3.52866079
93negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.52593678
94regulation of synaptic transmission, dopaminergic (GO:0032225)3.50692535
95regulation of the force of heart contraction (GO:0002026)3.48243636
96regulation of short-term neuronal synaptic plasticity (GO:0048172)3.47823908
97pyrimidine nucleotide catabolic process (GO:0006244)3.43482305
98L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.43441375
99cell differentiation involved in metanephros development (GO:0072202)3.42001955
100NADH metabolic process (GO:0006734)3.38053253
101response to interferon-beta (GO:0035456)3.37531560
102glutamate secretion (GO:0014047)3.36183910
103synaptic transmission, glutamatergic (GO:0035249)3.36001545
104regulation of cGMP metabolic process (GO:0030823)3.33691564
105response to auditory stimulus (GO:0010996)3.33449504
106grooming behavior (GO:0007625)3.31822890
107amino acid salvage (GO:0043102)3.28504183
108L-methionine salvage (GO:0071267)3.28504183
109L-methionine biosynthetic process (GO:0071265)3.28504183
110autophagic vacuole fusion (GO:0000046)3.27306091
111platelet dense granule organization (GO:0060155)3.27296534
112negative regulation of digestive system process (GO:0060457)3.26240595
113negative regulation of synaptic transmission (GO:0050805)3.25967103
114regulation of neurotransmitter transport (GO:0051588)3.23203167
115pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.22887262
116L-alpha-amino acid transmembrane transport (GO:1902475)3.22341908
117synaptic vesicle maturation (GO:0016188)3.22008752
118syncytium formation by plasma membrane fusion (GO:0000768)3.21827407
119phagocytosis, engulfment (GO:0006911)3.21766961
120mucosal-associated lymphoid tissue development (GO:0048537)3.21409601
121Peyers patch development (GO:0048541)3.21409601
122mature B cell differentiation involved in immune response (GO:0002313)3.20771542
123regulation of transmission of nerve impulse (GO:0051969)3.19840135
124purine nucleotide salvage (GO:0032261)3.18824004
125regulation of synaptic vesicle transport (GO:1902803)3.18664822
126regulation of sodium ion transmembrane transport (GO:1902305)3.18327616
127neuronal action potential propagation (GO:0019227)3.17598914
128forebrain morphogenesis (GO:0048853)3.17343407
129B cell mediated immunity (GO:0019724)3.16995601
130positive regulation of T cell differentiation in thymus (GO:0033089)3.16328450
131neurotransmitter-gated ion channel clustering (GO:0072578)3.14736987
132preassembly of GPI anchor in ER membrane (GO:0016254)3.14143237
133iron-sulfur cluster assembly (GO:0016226)3.13290713
134metallo-sulfur cluster assembly (GO:0031163)3.13290713
135cGMP biosynthetic process (GO:0006182)3.13040399
136oxaloacetate metabolic process (GO:0006107)3.08404219
137regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.07127687
138gamma-aminobutyric acid transport (GO:0015812)3.06725583
139central nervous system neuron development (GO:0021954)3.05014689
140* neuron-neuron synaptic transmission (GO:0007270)3.03989962
141deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.03400758
142tyrosine phosphorylation of STAT protein (GO:0007260)3.03209056
143regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.02327173
144positive regulation of digestive system process (GO:0060456)3.02054607
145positive regulation of excitatory postsynaptic membrane potential (GO:2000463)2.99153997
146opioid receptor signaling pathway (GO:0038003)2.97936513
147neurotransmitter transport (GO:0006836)2.97623363
148regulation of B cell differentiation (GO:0045577)2.96665384
149deoxyribonucleotide catabolic process (GO:0009264)2.96071265
150glutamate receptor signaling pathway (GO:0007215)2.95747276
151cGMP metabolic process (GO:0046068)2.95677841
152membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.94055238
153positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.92161567
154regulation of antigen processing and presentation (GO:0002577)2.92139680
155basic amino acid transport (GO:0015802)2.91696066
156negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.91684336
157presynaptic membrane organization (GO:0097090)2.90641837
158neutrophil activation involved in immune response (GO:0002283)2.90350347
159deoxyribose phosphate catabolic process (GO:0046386)2.88790996
160positive regulation of fatty acid biosynthetic process (GO:0045723)2.87775297
161regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.85182927
162poly(A)+ mRNA export from nucleus (GO:0016973)2.84117423
163ubiquinone biosynthetic process (GO:0006744)2.83201321
164mannosylation (GO:0097502)2.80113020
165purine-containing compound salvage (GO:0043101)2.79966567
166hematopoietic stem cell proliferation (GO:0071425)2.77062979
167GPI anchor biosynthetic process (GO:0006506)2.74722955
168positive regulation of antigen processing and presentation (GO:0002579)2.74694064
169estrogen biosynthetic process (GO:0006703)2.74420667
170negative regulation of erythrocyte differentiation (GO:0045647)2.71407741
171positive regulation of organic acid transport (GO:0032892)2.71204938
172regulation of glutamate secretion (GO:0014048)2.68052473
173tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.66607332
174RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.66607332
175negative regulation of nitric oxide biosynthetic process (GO:0045019)2.66049852
176phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)2.63444994
177regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.62989287
178organelle membrane fusion (GO:0090174)2.62431082
179inositol phosphate dephosphorylation (GO:0046855)2.58361010
180phosphorylated carbohydrate dephosphorylation (GO:0046838)2.58361010
181ribosomal small subunit assembly (GO:0000028)2.57754886
182thyroid gland development (GO:0030878)2.57020262
183tryptophan metabolic process (GO:0006568)2.55982027
184positive regulation of G1/S transition of mitotic cell cycle (GO:1900087)2.55251636
185endoderm formation (GO:0001706)2.54853363
186GPI anchor metabolic process (GO:0006505)2.53168851
187nucleotide salvage (GO:0043173)2.53125316
188indole-containing compound catabolic process (GO:0042436)2.51002726
189indolalkylamine catabolic process (GO:0046218)2.51002726
190tryptophan catabolic process (GO:0006569)2.51002726
191Arp2/3 complex-mediated actin nucleation (GO:0034314)2.50990886
192organ formation (GO:0048645)2.50562029
193histamine secretion (GO:0001821)2.49204719
194monoamine transport (GO:0015844)2.47682250
195positive thymic T cell selection (GO:0045059)2.47627896
196protein kinase C signaling (GO:0070528)2.47113537
197xenobiotic catabolic process (GO:0042178)2.46762612
198exogenous drug catabolic process (GO:0042738)15.6636257
199drug catabolic process (GO:0042737)12.5290996

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human5.96012778
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.96886351
3BP1_19119308_ChIP-ChIP_Hs578T_Human4.78357542
4IRF8_22096565_ChIP-ChIP_GC-B_Human4.59462023
5HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse4.44037692
6SCL_19346495_ChIP-Seq_HPC-7_Human4.10257182
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse3.81981066
8EZH2_22144423_ChIP-Seq_EOC_Human3.59815974
9TAF15_26573619_Chip-Seq_HEK293_Human3.56548816
10ELF1_17652178_ChIP-ChIP_JURKAT_Human3.28164657
11* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.23083049
12SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.89486993
13GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.83035611
14REST_21632747_ChIP-Seq_MESCs_Mouse2.65895205
15CTBP1_25329375_ChIP-Seq_LNCAP_Human2.57281676
16* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.53995352
17CTBP2_25329375_ChIP-Seq_LNCAP_Human2.50923297
18* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.50591825
19LYL1_20887958_ChIP-Seq_HPC-7_Mouse2.49980773
20DROSHA_22980978_ChIP-Seq_HELA_Human2.48714846
21* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.47359832
22MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.40210037
23RNF2_18974828_ChIP-Seq_MESCs_Mouse2.37733351
24EZH2_18974828_ChIP-Seq_MESCs_Mouse2.37733351
25JARID2_20064375_ChIP-Seq_MESCs_Mouse2.33923909
26REST_18959480_ChIP-ChIP_MESCs_Mouse2.29842512
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.24549132
28POU3F2_20337985_ChIP-ChIP_501MEL_Human2.21369450
29SMAD4_21799915_ChIP-Seq_A2780_Human2.21141225
30EED_16625203_ChIP-ChIP_MESCs_Mouse2.19071318
31P300_19829295_ChIP-Seq_ESCs_Human2.18975320
32IGF1R_20145208_ChIP-Seq_DFB_Human2.17732476
33EZH2_27304074_Chip-Seq_ESCs_Mouse2.17565321
34VDR_22108803_ChIP-Seq_LS180_Human2.15416669
35* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.12297216
36JARID2_20075857_ChIP-Seq_MESCs_Mouse2.08233634
37GATA2_21666600_ChIP-Seq_HMVEC_Human2.02719101
38ZFP57_27257070_Chip-Seq_ESCs_Mouse2.02459450
39IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.01656777
40* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.01260848
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.99456136
42MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.96299056
43PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.93345546
44OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.93109966
45HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.92561308
46LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.89407279
47ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88563217
48BMI1_23680149_ChIP-Seq_NPCS_Mouse1.85723688
49VDR_23849224_ChIP-Seq_CD4+_Human1.76491504
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.76093684
51SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.72522391
52CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.71395689
53IKZF1_21737484_ChIP-ChIP_HCT116_Human1.70973319
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69867530
55FUS_26573619_Chip-Seq_HEK293_Human1.69368809
56CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.68979731
57EWS_26573619_Chip-Seq_HEK293_Human1.67204016
58SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.66589004
59KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.64575329
60AR_21572438_ChIP-Seq_LNCaP_Human1.64173052
61FOXP3_21729870_ChIP-Seq_TREG_Human1.61678614
62RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.57430478
63HOXB4_20404135_ChIP-ChIP_EML_Mouse1.57219943
64RNF2_27304074_Chip-Seq_ESCs_Mouse1.56723954
65SOX2_21211035_ChIP-Seq_LN229_Gbm1.56639666
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.55725287
67AR_25329375_ChIP-Seq_VCAP_Human1.54217279
68DNAJC2_21179169_ChIP-ChIP_NT2_Human1.53918017
69FLI1_27457419_Chip-Seq_LIVER_Mouse1.53869069
70EZH2_27294783_Chip-Seq_ESCs_Mouse1.52594694
71SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52087637
72RARB_27405468_Chip-Seq_BRAIN_Mouse1.50385991
73TOP2B_26459242_ChIP-Seq_MCF-7_Human1.50112699
74SMAD3_21741376_ChIP-Seq_EPCs_Human1.49114200
75* SUZ12_27294783_Chip-Seq_ESCs_Mouse1.48641568
76PRDM14_20953172_ChIP-Seq_ESCs_Human1.47041424
77PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.46843577
78EGR1_23403033_ChIP-Seq_LIVER_Mouse1.46060276
79WT1_19549856_ChIP-ChIP_CCG9911_Human1.43429192
80CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43255353
81JUN_21703547_ChIP-Seq_K562_Human1.42356467
82* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.42354974
83ZNF274_21170338_ChIP-Seq_K562_Hela1.39637698
84MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.39541780
85ERG_21242973_ChIP-ChIP_JURKAT_Human1.39203876
86GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.37910914
87SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.36397423
88CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.35519759
89FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.35372926
90RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.34621763
91TP53_22573176_ChIP-Seq_HFKS_Human1.33724586
92GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.33721272
93RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.33399257
94EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.32679445
95CBP_20019798_ChIP-Seq_JUKART_Human1.28386725
96IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28386725
97IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.28340539
98TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.28339238
99GATA1_19941826_ChIP-Seq_K562_Human1.28032353
100NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.28014366
101NRF2_20460467_ChIP-Seq_MEFs_Mouse1.28014366
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26937941
103NANOG_19829295_ChIP-Seq_ESCs_Human1.25614382
104SOX2_19829295_ChIP-Seq_ESCs_Human1.25614382
105GABP_17652178_ChIP-ChIP_JURKAT_Human1.23979546
106HTT_18923047_ChIP-ChIP_STHdh_Human1.23770625
107CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23531072
108ER_23166858_ChIP-Seq_MCF-7_Human1.23164524
109MYB_26560356_Chip-Seq_TH2_Human1.22237327
110RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.22064589
111FOXA1_21572438_ChIP-Seq_LNCaP_Human1.20370205
112TRIM28_21343339_ChIP-Seq_HEK293_Human1.19947082
113MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19901034
114UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19049248
115SPI1_23547873_ChIP-Seq_NB4_Human1.18552594
116GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.17939560
117SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.17698109
118* STAT3_23295773_ChIP-Seq_U87_Human1.17316629
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17289838
120EST1_17652178_ChIP-ChIP_JURKAT_Human1.16535661
121MYC_18940864_ChIP-ChIP_HL60_Human1.16359931
122FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.16271653
123SALL1_21062744_ChIP-ChIP_HESCs_Human1.15919626
124ELK1_19687146_ChIP-ChIP_HELA_Human1.14751803
125GATA3_26560356_Chip-Seq_TH2_Human1.14157042
126CBX2_27304074_Chip-Seq_ESCs_Mouse1.12927164
127NANOG_20526341_ChIP-Seq_ESCs_Human1.12200536
128TP53_18474530_ChIP-ChIP_U2OS_Human1.10563737
129ETS1_20019798_ChIP-Seq_JURKAT_Human1.10388541
130TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10234442
131RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.10218446
132SMAD3_21741376_ChIP-Seq_ESCs_Human1.10135975
133TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.08238974
134PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.07971649
135PCGF2_27294783_Chip-Seq_ESCs_Mouse1.07911397
136AR_20517297_ChIP-Seq_VCAP_Human1.06231659
137TCF4_22108803_ChIP-Seq_LS180_Human1.04369271
138CDX2_19796622_ChIP-Seq_MESCs_Mouse1.03714675
139BCAT_22108803_ChIP-Seq_LS180_Human1.03319026
140CIITA_25753668_ChIP-Seq_RAJI_Human1.03063403
141JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.02722720
142ESR1_15608294_ChIP-ChIP_MCF-7_Human1.02273876
143VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.01697499
144FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.01466002
145CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.01416913
146FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.00998148
147NR3C1_23031785_ChIP-Seq_PC12_Mouse0.98284668
148YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97901460
149POU5F1_16153702_ChIP-ChIP_HESCs_Human0.97870357
150FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97833960
151SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97728058
152RUNX2_22187159_ChIP-Seq_PCA_Human0.97348015
153TCF4_23295773_ChIP-Seq_U87_Human0.97033293
154NR3C1_21868756_ChIP-Seq_MCF10A_Human0.96379250
155GATA3_27048872_Chip-Seq_THYMUS_Human0.96365349
156GATA2_22383799_ChIP-Seq_G1ME_Mouse0.95863103
157EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95498048
158IRF1_19129219_ChIP-ChIP_H3396_Human0.93990154
159IRF8_21731497_ChIP-ChIP_J774_Mouse0.93395475
160BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.93380907
161KDM2B_26808549_Chip-Seq_REH_Human0.92782415
162PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.92535741
163PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.89665622
164CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.89144576
165FOXA1_25329375_ChIP-Seq_VCAP_Human0.88811009
166FOXA1_27270436_Chip-Seq_PROSTATE_Human0.88811009
167ETV2_25802403_ChIP-Seq_MESCs_Mouse0.87964001
168AR_19668381_ChIP-Seq_PC3_Human0.87558746
169RUNX_20019798_ChIP-Seq_JUKART_Human0.87397206
170SALL4_22934838_ChIP-ChIP_CD34+_Human0.86605674
171ARNT_22903824_ChIP-Seq_MCF-7_Human0.86151545
172* TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.85917463
173NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.85660101
174MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.85651228
175STAT6_21828071_ChIP-Seq_BEAS2B_Human0.85648687
176STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.85018370
177CHD1_19587682_ChIP-ChIP_MESCs_Mouse0.84623506
178RNF2_27304074_Chip-Seq_NSC_Mouse0.84451580

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003646_muscle_fatigue7.16057712
2MP0006054_spinal_hemorrhage5.73265236
3MP0001529_abnormal_vocalization4.98516650
4MP0005645_abnormal_hypothalamus_physiol4.98218949
5MP0004858_abnormal_nervous_system4.67968173
6MP0004043_abnormal_pH_regulation3.72176658
7MP0004233_abnormal_muscle_weight3.51869518
8MP0005167_abnormal_blood-brain_barrier3.47814727
9MP0001501_abnormal_sleep_pattern3.33454857
10MP0005084_abnormal_gallbladder_morpholo3.16062216
11MP0002736_abnormal_nociception_after3.08500646
12MP0004084_abnormal_cardiac_muscle3.06400328
13MP0005397_hematopoietic_system_phenotyp2.90961708
14MP0001545_abnormal_hematopoietic_system2.90961708
15MP0003045_fibrosis2.90370273
16MP0010368_abnormal_lymphatic_system2.90316400
17MP0005464_abnormal_platelet_physiology2.80715965
18MP0000465_gastrointestinal_hemorrhage2.78043884
19MP0004859_abnormal_synaptic_plasticity2.77962180
20MP0003283_abnormal_digestive_organ2.71114399
21MP0006292_abnormal_olfactory_placode2.70549861
22MP0009278_abnormal_bone_marrow2.66859402
23MP0003635_abnormal_synaptic_transmissio2.62301764
24MP0002064_seizures2.59046245
25MP0002139_abnormal_hepatobiliary_system2.52960002
26MP0001968_abnormal_touch/_nociception2.51544389
27MP0002272_abnormal_nervous_system2.46917371
28MP0009046_muscle_twitch2.46880288
29MP0009745_abnormal_behavioral_response2.46601091
30MP0002138_abnormal_hepatobiliary_system2.43075331
31MP0003191_abnormal_cellular_cholesterol2.42299619
32MP0002735_abnormal_chemical_nociception2.38153290
33MP0008775_abnormal_heart_ventricle2.37613274
34MP0004036_abnormal_muscle_relaxation2.33588951
35MP0003806_abnormal_nucleotide_metabolis2.27206231
36MP0008004_abnormal_stomach_pH2.26700712
37MP0001440_abnormal_grooming_behavior2.26180023
38MP0004808_abnormal_hematopoietic_stem2.24618327
39MP0003787_abnormal_imprinting2.21831879
40MP0008872_abnormal_physiological_respon2.17579370
41MP0003724_increased_susceptibility_to2.09089063
42MP0003195_calcinosis2.06989876
43MP0003122_maternal_imprinting2.03830865
44MP0004883_abnormal_blood_vessel1.95735891
45MP0008875_abnormal_xenobiotic_pharmacok1.91351232
46MP0004484_altered_response_of1.90401529
47* MP0002572_abnormal_emotion/affect_behav1.80938273
48MP0002063_abnormal_learning/memory/cond1.73708632
49MP0002396_abnormal_hematopoietic_system1.69334605
50MP0005367_renal/urinary_system_phenotyp1.64746066
51MP0000516_abnormal_urinary_system1.64746066
52MP0008058_abnormal_DNA_repair1.63889850
53MP0000467_abnormal_esophagus_morphology1.63876560
54MP0000681_abnormal_thyroid_gland1.62715096
55MP0008995_early_reproductive_senescence1.60877516
56MP0006138_congestive_heart_failure1.58523308
57MP0003880_abnormal_central_pattern1.56983449
58MP0002148_abnormal_hypersensitivity_rea1.55070342
59MP0002837_dystrophic_cardiac_calcinosis1.54841692
60MP0001835_abnormal_antigen_presentation1.54234647
61MP0002734_abnormal_mechanical_nocicepti1.50929155
62MP0002876_abnormal_thyroid_physiology1.45919959
63MP0001970_abnormal_pain_threshold1.43607155
64MP0003315_abnormal_perineum_morphology1.42039261
65MP0002277_abnormal_respiratory_mucosa1.41529721
66MP0005386_behavior/neurological_phenoty1.38862984
67MP0004924_abnormal_behavior1.38862984
68MP0002234_abnormal_pharynx_morphology1.35396786
69MP0002132_abnormal_respiratory_system1.28502660
70MP0001664_abnormal_digestion1.28213932
71MP0001764_abnormal_homeostasis1.27310656
72MP0006276_abnormal_autonomic_nervous1.25058282
73MP0009250_abnormal_appendicular_skeleto1.24972262
74MP0003718_maternal_effect1.24315821
75MP0003943_abnormal_hepatobiliary_system1.23188920
76MP0003075_altered_response_to1.22099365
77MP0003866_abnormal_defecation1.22008042
78MP0002557_abnormal_social/conspecific_i1.16216012
79MP0008877_abnormal_DNA_methylation1.15825272
80MP0004811_abnormal_neuron_physiology1.15259867
81MP0001879_abnormal_lymphatic_vessel1.10693341
82MP0008874_decreased_physiological_sensi1.06333196
83MP0000013_abnormal_adipose_tissue1.05498818
84MP0002733_abnormal_thermal_nociception1.04242777
85MP0005075_abnormal_melanosome_morpholog1.04092579
86MP0005085_abnormal_gallbladder_physiolo1.03444729
87MP0002184_abnormal_innervation1.01520643
88MP0005410_abnormal_fertilization1.01504766
89MP0002067_abnormal_sensory_capabilities1.00640040
90MP0005423_abnormal_somatic_nervous1.00176690
91MP0001486_abnormal_startle_reflex0.96110315
92MP0004270_analgesia0.96105215
93MP0004142_abnormal_muscle_tone0.95422669
94MP0006036_abnormal_mitochondrial_physio0.95365555
95MP0003279_aneurysm0.95072652
96MP0002168_other_aberrant_phenotype0.92826289
97MP0003633_abnormal_nervous_system0.92625546
98MP0005164_abnormal_response_to0.87304037
99MP0001905_abnormal_dopamine_level0.87083396
100MP0002398_abnormal_bone_marrow0.86419788
101MP0002127_abnormal_cardiovascular_syste0.86406671
102MP0001984_abnormal_olfaction0.85051301
103MP0000955_abnormal_spinal_cord0.82362676
104MP0000689_abnormal_spleen_morphology0.82175202
105MP0000751_myopathy0.81243137
106MP0003656_abnormal_erythrocyte_physiolo0.80993742
107MP0004145_abnormal_muscle_electrophysio0.80898240
108MP0003121_genomic_imprinting0.79745925
109MP0008469_abnormal_protein_level0.79715554
110MP0005000_abnormal_immune_tolerance0.79682392
111MP0003252_abnormal_bile_duct0.79636156
112MP0002822_catalepsy0.78656684
113MP0005165_increased_susceptibility_to0.78206203
114MP0009765_abnormal_xenobiotic_induced0.78142309
115MP0005197_abnormal_uvea_morphology0.78043710
116MP0001666_abnormal_nutrient_absorption0.77398212
117MP0003631_nervous_system_phenotype0.75776437
118MP0010329_abnormal_lipoprotein_level0.73496776
119MP0002928_abnormal_bile_duct0.73428254
120MP0003303_peritoneal_inflammation0.73209867
121MP0001851_eye_inflammation0.72878525
122MP0002332_abnormal_exercise_endurance0.72360460
123MP0001663_abnormal_digestive_system0.71194652
124MP0004085_abnormal_heartbeat0.70338192
125MP0004782_abnormal_surfactant_physiolog0.70213377
126MP0002066_abnormal_motor_capabilities/c0.69733658
127MP0002019_abnormal_tumor_incidence0.69503718
128MP0005360_urolithiasis0.69028863
129MP0002009_preneoplasia0.68515015
130MP0004147_increased_porphyrin_level0.68303306
131MP0003329_amyloid_beta_deposits0.67445539
132MP0005551_abnormal_eye_electrophysiolog0.65709195
133MP0001119_abnormal_female_reproductive0.65654233
134MP0003786_premature_aging0.65144203
135MP0000049_abnormal_middle_ear0.64915267
136MP0003186_abnormal_redox_activity0.64451786
137MP0005394_taste/olfaction_phenotype0.64235882
138MP0005499_abnormal_olfactory_system0.64235882
139MP0000230_abnormal_systemic_arterial0.62800458
140MP0004215_abnormal_myocardial_fiber0.62581403
141MP0005535_abnormal_body_temperature0.62064980
142MP0002909_abnormal_adrenal_gland0.61778717
143MP0005220_abnormal_exocrine_pancreas0.61403331
144MP0001177_atelectasis0.61287684
145MP0009764_decreased_sensitivity_to0.60986057
146MP0002419_abnormal_innate_immunity0.60776922
147MP0002429_abnormal_blood_cell0.60526867
148MP0002723_abnormal_immune_serum0.59904914
149MP0003119_abnormal_digestive_system0.59698912
150MP0000598_abnormal_liver_morphology0.59280312
151MP0002932_abnormal_joint_morphology0.59181960
152MP0001661_extended_life_span0.59075334
153MP0009697_abnormal_copulation0.58403499
154MP0002160_abnormal_reproductive_system0.57936548
155MP0002722_abnormal_immune_system0.57818189
156MP0001929_abnormal_gametogenesis0.57644450
157MP0002420_abnormal_adaptive_immunity0.57608015
158MP0005166_decreased_susceptibility_to0.57406478
159MP0003879_abnormal_hair_cell0.56980553
160MP0002882_abnormal_neuron_morphology0.56729565
161MP0005623_abnormal_meninges_morphology0.56527938
162MP0008569_lethality_at_weaning0.55520138
163MP0005332_abnormal_amino_acid0.54561945
164MP0002254_reproductive_system_inflammat0.52522860
165* MP0002069_abnormal_eating/drinking_beha0.50827452
166MP0005646_abnormal_pituitary_gland0.49880254
167MP0001986_abnormal_taste_sensitivity0.49239646
168MP0000470_abnormal_stomach_morphology0.48882432
169MP0003183_abnormal_peptide_metabolism0.48131072
170MP0005376_homeostasis/metabolism_phenot0.48056188
171MP0001943_abnormal_respiration0.47486600
172MP0005381_digestive/alimentary_phenotyp0.46344046
173MP0002972_abnormal_cardiac_muscle0.43607229

Predicted human phenotypes

RankGene SetZ-score
1Abnormal hair whorl (HP:0010721)6.78905431
2Oligomenorrhea (HP:0000876)6.14750413
3Abnormality of the labia minora (HP:0012880)5.38497282
4Neuroendocrine neoplasm (HP:0100634)4.98563434
5Focal motor seizures (HP:0011153)4.84206657
6Myokymia (HP:0002411)4.77719679
7Polyphagia (HP:0002591)4.72094314
8Pheochromocytoma (HP:0002666)4.62935715
9Poor suck (HP:0002033)4.46853472
10Failure to thrive in infancy (HP:0001531)4.42654760
11Dyschromatopsia (HP:0007641)4.36486915
12Gonadal dysgenesis (HP:0000133)4.34559213
13Atonic seizures (HP:0010819)4.23010544
14Abolished electroretinogram (ERG) (HP:0000550)4.16779574
15Spastic diplegia (HP:0001264)4.12142893
16Abnormality of the 1st metacarpal (HP:0010009)4.01536744
17Resting tremor (HP:0002322)3.83143230
18Focal seizures (HP:0007359)3.82388105
19Thrombocytosis (HP:0001894)3.74335705
20Narrow nasal bridge (HP:0000446)3.72376808
21Generalized tonic-clonic seizures (HP:0002069)3.64906804
22Abnormal mitochondria in muscle tissue (HP:0008316)3.59591953
23Epileptic encephalopathy (HP:0200134)3.56951931
24Acute necrotizing encephalopathy (HP:0006965)3.49703358
25Abnormal eating behavior (HP:0100738)3.43394102
26Decreased central vision (HP:0007663)3.42547612
27Visual hallucinations (HP:0002367)3.38696157
28Absence seizures (HP:0002121)3.37635604
29Panhypogammaglobulinemia (HP:0003139)3.34720337
30Absent rod-and cone-mediated responses on ERG (HP:0007688)3.19015210
31Abnormality of the heme biosynthetic pathway (HP:0010472)3.17593895
32Decreased electroretinogram (ERG) amplitude (HP:0000654)3.16192842
33Abnormality of pain sensation (HP:0010832)3.14905640
34Impaired pain sensation (HP:0007328)3.14905640
35Short phalanx of the thumb (HP:0009660)3.14197824
36Increased intramyocellular lipid droplets (HP:0012240)3.12191776
37Abnormality of the vocal cords (HP:0008777)3.11987660
38Progressive cerebellar ataxia (HP:0002073)3.10218868
39Impaired vibration sensation in the lower limbs (HP:0002166)3.09445953
40Increased muscle lipid content (HP:0009058)3.06585917
41Facial diplegia (HP:0001349)3.02901355
42Febrile seizures (HP:0002373)3.00772807
43Progressive macrocephaly (HP:0004481)2.99143646
44Generalized hypotonia (HP:0001290)2.95236360
45Epileptiform EEG discharges (HP:0011182)2.92691757
46Increased serum pyruvate (HP:0003542)2.91058773
47Abnormality of glycolysis (HP:0004366)2.91058773
48Hypothermia (HP:0002045)2.89400606
49Aplastic anemia (HP:0001915)2.87999540
50Hypoventilation (HP:0002791)2.87575241
51Esotropia (HP:0000565)2.87192551
52Hyperventilation (HP:0002883)2.86171687
53Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)2.84905627
54Short 1st metacarpal (HP:0010034)2.84905627
55Neoplasm of the peripheral nervous system (HP:0100007)2.80399671
56Mitochondrial inheritance (HP:0001427)2.79968629
57Abnormality of macular pigmentation (HP:0008002)2.79749934
58Acute encephalopathy (HP:0006846)2.79234387
59Hip dysplasia (HP:0001385)2.78526894
60Tongue fasciculations (HP:0001308)2.75735317
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.75168301
62Abnormal protein N-linked glycosylation (HP:0012347)2.75168301
63Abnormal protein glycosylation (HP:0012346)2.75168301
64Abnormal glycosylation (HP:0012345)2.75168301
65Methylmalonic acidemia (HP:0002912)2.74514564
66Hyperglycinemia (HP:0002154)2.74236664
67Elevated erythrocyte sedimentation rate (HP:0003565)2.74172198
68Dialeptic seizures (HP:0011146)2.74098919
69Short tibia (HP:0005736)2.72607980
70Gonadotropin excess (HP:0000837)2.70785061
71Abnormal gallbladder physiology (HP:0012438)2.68805411
72Cholecystitis (HP:0001082)2.68805411
73Reduced antithrombin III activity (HP:0001976)2.67058837
74Abnormal rod and cone electroretinograms (HP:0008323)2.67044454
75Dysdiadochokinesis (HP:0002075)2.64431797
76Acute lymphatic leukemia (HP:0006721)2.64427201
77EEG with generalized epileptiform discharges (HP:0011198)2.63218135
78Specific learning disability (HP:0001328)2.60596507
79Hypsarrhythmia (HP:0002521)2.60195416
80Hepatocellular necrosis (HP:0001404)2.59035714
81Attenuation of retinal blood vessels (HP:0007843)2.58617519
82Lipid accumulation in hepatocytes (HP:0006561)2.57506324
83Central scotoma (HP:0000603)2.56950202
84Prolonged bleeding time (HP:0003010)2.56071729
85Epistaxis (HP:0000421)2.55413162
86Labial hypoplasia (HP:0000066)2.52830093
87Abnormality of the prostate (HP:0008775)2.49677258
88Delayed CNS myelination (HP:0002188)2.49176383
89Sleep apnea (HP:0010535)2.46775993
90Spastic tetraplegia (HP:0002510)2.44999301
91Muscle fibrillation (HP:0010546)2.44478509
92Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.43682411
93Degeneration of the lateral corticospinal tracts (HP:0002314)2.43682411
94Aplasia/Hypoplasia of the tibia (HP:0005772)2.43190569
95Gait imbalance (HP:0002141)2.42761887
96Leukodystrophy (HP:0002415)2.42716445
97Gingival bleeding (HP:0000225)2.42118607
98Stomatitis (HP:0010280)2.41936513
99Abnormality of the corticospinal tract (HP:0002492)2.40692437
100Cerebral edema (HP:0002181)2.39363304
101Abnormality of B cell number (HP:0010975)2.38014221
102Decreased activity of mitochondrial respiratory chain (HP:0008972)2.37479783
103Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.37479783
104Renal Fanconi syndrome (HP:0001994)2.36385094
105Microvesicular hepatic steatosis (HP:0001414)2.35620715
106Increased CSF lactate (HP:0002490)2.35336210
107Psychosis (HP:0000709)2.32305051
108Neoplasm of head and neck (HP:0012288)2.32225683
109Esophageal neoplasm (HP:0100751)2.32225683
110Anxiety (HP:0000739)2.30708085
111Truncal ataxia (HP:0002078)2.30695892
112Nasal speech (HP:0001611)2.29125327
113Abnormal gallbladder morphology (HP:0012437)2.28483751
114Type I transferrin isoform profile (HP:0003642)2.28373083
115Termporal pattern (HP:0011008)2.28025721
116Insidious onset (HP:0003587)2.28025721
117Cone-rod dystrophy (HP:0000548)2.27775140
118Hyperglycinuria (HP:0003108)2.27507618
119Cholelithiasis (HP:0001081)2.27094494
120Hypoplastic female external genitalia (HP:0012815)2.26102038
121Tubulointerstitial nephritis (HP:0001970)2.25643903
122Amaurosis fugax (HP:0100576)2.23681386
123Stomach cancer (HP:0012126)2.22975298
124Agammaglobulinemia (HP:0004432)2.22924710
125Abnormality of dicarboxylic acid metabolism (HP:0010995)2.22738845
126Dicarboxylic aciduria (HP:0003215)2.22738845
127Generalized myoclonic seizures (HP:0002123)2.19361787
128Aplasia/Hypoplasia of the phalanges of the thumb (HP:0009658)2.17912208
129Growth hormone deficiency (HP:0000824)2.16488916
130Congenital primary aphakia (HP:0007707)2.16279363
131Metaphyseal dysplasia (HP:0100255)2.16182308
132Abnormal biliary tract physiology (HP:0012439)2.14923545
133Bile duct proliferation (HP:0001408)2.14923545
134Long foot (HP:0001833)2.13591925
135Increased hepatocellular lipid droplets (HP:0006565)2.13540048
136Congenital stationary night blindness (HP:0007642)2.11800744
137Hypogonadotrophic hypogonadism (HP:0000044)2.11010542
138Seborrheic dermatitis (HP:0001051)2.10393907
139Decreased muscle mass (HP:0003199)2.10220978
140Akinesia (HP:0002304)2.10032687
141Abnormality of serine family amino acid metabolism (HP:0010894)2.09051003
142Abnormality of glycine metabolism (HP:0010895)2.09051003
143Myelodysplasia (HP:0002863)2.07777083
144Portal hypertension (HP:0001409)2.07146911
145Depression (HP:0000716)2.06982132
146Muscular hypotonia of the trunk (HP:0008936)2.05763702
147Myositis (HP:0100614)2.04777860
148Spontaneous abortion (HP:0005268)2.03398571
149Hypoplasia of the brainstem (HP:0002365)2.02905779
150Aplasia/Hypoplasia of the brainstem (HP:0007362)2.02905779
151Nephrogenic diabetes insipidus (HP:0009806)2.02825400
152Macular degeneration (HP:0000608)2.02071015
153Ketosis (HP:0001946)2.00555495
154Intellectual disability, profound (HP:0002187)2.00464114
155Bradykinesia (HP:0002067)2.00085247
156Medial flaring of the eyebrow (HP:0010747)1.99914119
157Arterial thrombosis (HP:0004420)1.99089185
158Diplopia (HP:0000651)1.98631119
159Abnormality of binocular vision (HP:0011514)1.98631119
160Conjunctival hamartoma (HP:0100780)1.96621132
161Exertional dyspnea (HP:0002875)1.94445404
162Scanning speech (HP:0002168)1.93151785
163Urinary urgency (HP:0000012)1.92770108
164Abnormality of the gallbladder (HP:0005264)1.92019678
165Scotoma (HP:0000575)1.91629732
166Lethargy (HP:0001254)1.90292617
167Abnormality of male internal genitalia (HP:0000022)1.90253939
168Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.89522752
169Methylmalonic aciduria (HP:0012120)1.88803195
170Abnormal delayed hypersensitivity skin test (HP:0002963)1.88099114
171Impaired vibratory sensation (HP:0002495)1.87451285
172Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.87065385
173Abnormality of alanine metabolism (HP:0010916)1.87065385
174Hyperalaninemia (HP:0003348)1.87065385
175Hepatic necrosis (HP:0002605)1.86108790
176Fetal akinesia sequence (HP:0001989)1.85476290
177Abnormality of the proximal phalanges of the hand (HP:0009834)1.84674353
178Abnormality of the hepatic vasculature (HP:0006707)1.84545343
179Progressive inability to walk (HP:0002505)1.84206143
180Acute hepatic failure (HP:0006554)1.84183290
181Thrombophlebitis (HP:0004418)1.83405291
182Premature ovarian failure (HP:0008209)1.83100093
183Cerebral palsy (HP:0100021)1.82418435
184Short hallux (HP:0010109)1.81887792
185Aplasia/Hypoplasia of the hallux (HP:0008362)1.81272016
186Chest pain (HP:0100749)1.80794784
187Increased neuronal autofluorescent lipopigment (HP:0002074)1.80631783
188Pigmentary retinal degeneration (HP:0001146)1.80526205
189Chronic otitis media (HP:0000389)1.79708821
190Lactic acidosis (HP:0003128)1.78331671
191Pancytopenia (HP:0001876)1.77245489
192Constricted visual fields (HP:0001133)1.75254150
193Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.75060662
194Type 2 muscle fiber atrophy (HP:0003554)1.74854483
195Abnormality of the vitamin B12 metabolism (HP:0004341)1.74460863
196Nephronophthisis (HP:0000090)1.73849577

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K125.03998600
2MAP3K44.97210422
3GRK74.95924224
4MAP2K74.88703031
5TAOK34.81275427
6BCKDK4.16147483
7CASK3.50265072
8NUAK13.42875524
9TIE13.37722461
10PBK2.98123649
11MAP2K42.93233674
12KIT2.82537117
13CAMK42.72924608
14PINK12.69553806
15AKT32.69198185
16STK102.51521496
17CAMK12.50085826
18RPS6KL12.32201810
19RPS6KC12.32201810
20KDR2.12695674
21MAP4K12.08663362
22MYLK2.01411066
23RPS6KA61.99492144
24TEC1.97832598
25DAPK11.97233419
26NTRK21.97124976
27EIF2AK31.94029339
28ZAK1.91955877
29FLT31.91002464
30TSSK61.88456846
31MAP4K21.86787256
32SCYL21.82913541
33NME11.82588770
34PLK21.71097506
35PDK41.67238371
36PDK31.67238371
37LRRK21.63212313
38MATK1.54532033
39NTRK31.53763671
40MAP3K111.53113956
41ARAF1.52002715
42TBK11.48951437
43CDK191.39927960
44MINK11.36658195
45UHMK11.32934668
46DAPK21.30661720
47CAMK2A1.27095944
48MAP3K91.26223738
49MARK11.24647238
50BMPR1B1.24202192
51CSF1R1.23084655
52SGK4941.21963076
53SGK2231.21963076
54TNK21.20572726
55PRKG21.19938404
56PIK3CG1.19495096
57FRK1.17497349
58MAPK131.17359517
59GRK51.16537170
60NEK11.14660964
61SGK21.13341567
62PRKCG1.11816163
63ADRBK11.10439855
64JAK31.09615363
65MAP3K131.05366496
66PRKCE1.02994092
67MAP3K61.02610715
68PLK41.02115777
69BTK0.98507700
70MAP3K140.96581216
71MKNK10.96540969
72TXK0.95886827
73OXSR10.95660158
74CCNB10.95336902
75FES0.95186275
76CAMK2B0.94925340
77BRAF0.92918879
78VRK20.92056127
79EPHA40.90109334
80SGK30.88056244
81PDK20.87409579
82IKBKE0.85901746
83DAPK30.84765138
84MAP2K30.84078177
85GRK10.81710350
86CDK50.81251350
87PRPF4B0.79976594
88ALK0.77912311
89ITK0.77881500
90PRKD30.75736905
91TAF10.75086196
92PRKD20.74521633
93IKBKB0.72132321
94NME20.71028209
95RPS6KA20.68842842
96LCK0.68222519
97BRSK20.67710330
98CDK30.67439352
99RPS6KA50.66248367
100PRKCH0.65831454
101LIMK10.64988746
102TRIM280.63963721
103VRK10.63586404
104SIK30.61779905
105IGF1R0.61612372
106MAP2K20.61208561
107TGFBR10.59437189
108CAMK2D0.58602299
109PHKG10.56494960
110PHKG20.56494960
111TLK10.56392784
112MAP2K10.55930947
113CAMK2G0.55894850
114CSNK1G10.51935063
115PIM20.51897107
116FER0.50952935
117WNK30.50648266
118MAP3K50.50106008
119ERBB30.50089547
120HCK0.50087387
121RPS6KB20.49674782
122ROCK20.49527074
123CAMKK10.48005576
124CSNK1G30.47767806
125EIF2AK20.46591223
126CDK180.44174893
127CDK140.43148792
128LYN0.41947697
129YES10.41607642
130NTRK10.41480646
131PRKACG0.41135118
132INSRR0.40865956
133CDK150.39395694
134CDK90.39102836
135MST40.38878848
136LMTK20.38541267
137MAPK30.38515313
138CDC70.38063544
139RPS6KB10.37767165
140PTK2B0.37345530
141PRKACA0.37238974
142PRKCD0.35775796
143SGK10.35323346
144MAP3K10.34368843
145PLK30.34253600
146ERBB40.33789244
147PRKCA0.33097177
148BCR0.29850036
149TRPM70.29664818
150MAP3K80.29103928
151CDK11A0.28463168
152STK240.27604045
153PAK40.27520594
154TNIK0.27028286
155RPS6KA40.26908596
156PRKCB0.26819312
157MKNK20.25462843
158GRK60.25031104
159MAP2K60.24958627
160SRC0.24929713
161NLK0.24794858
162MARK20.23865297
163PAK30.20794251
164FYN0.20076761
165PRKCQ0.19546233
166ADRBK20.19243317
167PDK10.18593985
168BMPR20.17455746
169SYK0.17440556
170RPS6KA30.17034380
171PRKG10.15290606
172CSNK1G20.15128806
173CSNK1E0.14424124

Predicted pathways (KEGG)

RankGene SetZ-score
1Taurine and hypotaurine metabolism_Homo sapiens_hsa004304.31638721
2Arginine biosynthesis_Homo sapiens_hsa002204.05821343
3Collecting duct acid secretion_Homo sapiens_hsa049663.93215346
4Asthma_Homo sapiens_hsa053103.77884257
5Synaptic vesicle cycle_Homo sapiens_hsa047213.57316591
6Allograft rejection_Homo sapiens_hsa053303.22584945
7Nicotine addiction_Homo sapiens_hsa050332.88874170
8Vibrio cholerae infection_Homo sapiens_hsa051102.68622674
9Autoimmune thyroid disease_Homo sapiens_hsa053202.56512155
10Graft-versus-host disease_Homo sapiens_hsa053322.55824036
11Intestinal immune network for IgA production_Homo sapiens_hsa046722.38832903
12GABAergic synapse_Homo sapiens_hsa047272.35930715
13Oxidative phosphorylation_Homo sapiens_hsa001902.32548628
14Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.32353931
15Butanoate metabolism_Homo sapiens_hsa006502.20260991
16Circadian entrainment_Homo sapiens_hsa047132.15693638
17Type I diabetes mellitus_Homo sapiens_hsa049402.13388365
18Long-term depression_Homo sapiens_hsa047302.12812979
19Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.12000744
20Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002502.11776166
21Salivary secretion_Homo sapiens_hsa049702.07968265
22Olfactory transduction_Homo sapiens_hsa047401.99529801
23Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.96311740
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.95573697
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.95351398
26Morphine addiction_Homo sapiens_hsa050321.89293296
27Staphylococcus aureus infection_Homo sapiens_hsa051501.84024657
28SNARE interactions in vesicular transport_Homo sapiens_hsa041301.81246580
29Taste transduction_Homo sapiens_hsa047421.78967111
30Phagosome_Homo sapiens_hsa041451.78070242
31Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.66386385
32Calcium signaling pathway_Homo sapiens_hsa040201.64453547
33Arachidonic acid metabolism_Homo sapiens_hsa005901.60515831
34Peroxisome_Homo sapiens_hsa041461.57409629
35Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.56533624
36Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.56215048
37Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.53129475
38Non-homologous end-joining_Homo sapiens_hsa034501.53080237
39Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.50260101
40Glutamatergic synapse_Homo sapiens_hsa047241.50001095
41Rheumatoid arthritis_Homo sapiens_hsa053231.48717515
42Base excision repair_Homo sapiens_hsa034101.47191712
43Alzheimers disease_Homo sapiens_hsa050101.46922035
44Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.46194173
45Steroid hormone biosynthesis_Homo sapiens_hsa001401.44863312
46Linoleic acid metabolism_Homo sapiens_hsa005911.44241389
47Fatty acid elongation_Homo sapiens_hsa000621.42173035
48Leishmaniasis_Homo sapiens_hsa051401.40680606
49Platelet activation_Homo sapiens_hsa046111.38732065
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.38306315
51Pyruvate metabolism_Homo sapiens_hsa006201.34953272
52Renin secretion_Homo sapiens_hsa049241.34629023
532-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.32011940
54Parkinsons disease_Homo sapiens_hsa050121.31814741
55Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.31680724
56Antigen processing and presentation_Homo sapiens_hsa046121.30575319
57Long-term potentiation_Homo sapiens_hsa047201.29805037
58Chemical carcinogenesis_Homo sapiens_hsa052041.29415533
59Phototransduction_Homo sapiens_hsa047441.23380071
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.23319790
61Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.22247050
62RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.21547736
63Dopaminergic synapse_Homo sapiens_hsa047281.19412805
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.17852085
65Fatty acid degradation_Homo sapiens_hsa000711.16672388
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13906596
67Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.13633533
68Amphetamine addiction_Homo sapiens_hsa050311.13317289
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.12648059
70Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09534919
71Gastric acid secretion_Homo sapiens_hsa049711.07952068
72Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.07925260
73Serotonergic synapse_Homo sapiens_hsa047261.06633011
74Retinol metabolism_Homo sapiens_hsa008301.04796224
75Cholinergic synapse_Homo sapiens_hsa047251.03188866
76Tryptophan metabolism_Homo sapiens_hsa003801.03042899
77beta-Alanine metabolism_Homo sapiens_hsa004100.99521773
78Herpes simplex infection_Homo sapiens_hsa051680.98979945
79Arginine and proline metabolism_Homo sapiens_hsa003300.96851273
80Systemic lupus erythematosus_Homo sapiens_hsa053220.96804796
81Gap junction_Homo sapiens_hsa045400.96530942
82Caffeine metabolism_Homo sapiens_hsa002320.95746644
83alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.95147955
84Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.94692918
85Insulin secretion_Homo sapiens_hsa049110.94175369
86Transcriptional misregulation in cancer_Homo sapiens_hsa052020.93703302
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.92473714
88NOD-like receptor signaling pathway_Homo sapiens_hsa046210.90119019
89Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85044439
90Ovarian steroidogenesis_Homo sapiens_hsa049130.83813582
91Fanconi anemia pathway_Homo sapiens_hsa034600.81584043
92Aldosterone synthesis and secretion_Homo sapiens_hsa049250.80872557
93cAMP signaling pathway_Homo sapiens_hsa040240.80295629
94Purine metabolism_Homo sapiens_hsa002300.78740464
95Primary bile acid biosynthesis_Homo sapiens_hsa001200.77468827
96Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.75951907
97Huntingtons disease_Homo sapiens_hsa050160.74738795
98One carbon pool by folate_Homo sapiens_hsa006700.73492738
99Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.73149522
100RNA degradation_Homo sapiens_hsa030180.73013982
101Viral myocarditis_Homo sapiens_hsa054160.72413237
102Primary immunodeficiency_Homo sapiens_hsa053400.71342281
103Selenocompound metabolism_Homo sapiens_hsa004500.70570844
104Oxytocin signaling pathway_Homo sapiens_hsa049210.68060491
105Hematopoietic cell lineage_Homo sapiens_hsa046400.67449099
106Tyrosine metabolism_Homo sapiens_hsa003500.66734335
107Pentose and glucuronate interconversions_Homo sapiens_hsa000400.66093324
108Vitamin B6 metabolism_Homo sapiens_hsa007500.65966638
109Ether lipid metabolism_Homo sapiens_hsa005650.65836261
110Cardiac muscle contraction_Homo sapiens_hsa042600.64782778
111Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.64109731
112Type II diabetes mellitus_Homo sapiens_hsa049300.63676453
113Ribosome_Homo sapiens_hsa030100.63203790
114Cocaine addiction_Homo sapiens_hsa050300.63203510
115Maturity onset diabetes of the young_Homo sapiens_hsa049500.63136164
116Glycerophospholipid metabolism_Homo sapiens_hsa005640.62706784
117Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.62374415
118Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61300577
119Carbon metabolism_Homo sapiens_hsa012000.59440855
120Biosynthesis of amino acids_Homo sapiens_hsa012300.59242036
121Complement and coagulation cascades_Homo sapiens_hsa046100.57282309
122Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54677657
123Thyroid hormone synthesis_Homo sapiens_hsa049180.54299322
124Pyrimidine metabolism_Homo sapiens_hsa002400.54023029
125ABC transporters_Homo sapiens_hsa020100.53100003
126Jak-STAT signaling pathway_Homo sapiens_hsa046300.51825690
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.51737856
128Alcoholism_Homo sapiens_hsa050340.51054661
129Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.50989570
130Fatty acid metabolism_Homo sapiens_hsa012120.48853205
131RNA polymerase_Homo sapiens_hsa030200.47815698
132Inositol phosphate metabolism_Homo sapiens_hsa005620.43954617
133Propanoate metabolism_Homo sapiens_hsa006400.43026247
134Vascular smooth muscle contraction_Homo sapiens_hsa042700.40264908
135Pertussis_Homo sapiens_hsa051330.38728878
136Toxoplasmosis_Homo sapiens_hsa051450.38043895
137Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36806734
138Homologous recombination_Homo sapiens_hsa034400.36731811
139Cysteine and methionine metabolism_Homo sapiens_hsa002700.36478103
140Fat digestion and absorption_Homo sapiens_hsa049750.36385152
141Dilated cardiomyopathy_Homo sapiens_hsa054140.36014404
142Regulation of autophagy_Homo sapiens_hsa041400.35794097
143Other glycan degradation_Homo sapiens_hsa005110.34700524
144Vitamin digestion and absorption_Homo sapiens_hsa049770.34434697
145Phosphatidylinositol signaling system_Homo sapiens_hsa040700.32886164
146ErbB signaling pathway_Homo sapiens_hsa040120.32806959
147Glucagon signaling pathway_Homo sapiens_hsa049220.30528000
148GnRH signaling pathway_Homo sapiens_hsa049120.28773016
149cGMP-PKG signaling pathway_Homo sapiens_hsa040220.23441188
150Shigellosis_Homo sapiens_hsa051310.22628830
151Axon guidance_Homo sapiens_hsa043600.22253794
152Phenylalanine metabolism_Homo sapiens_hsa003600.19665461
153Glycerolipid metabolism_Homo sapiens_hsa005610.18805518
154Proteasome_Homo sapiens_hsa030500.16173199
155Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.15118289
156African trypanosomiasis_Homo sapiens_hsa051430.14068813
157MAPK signaling pathway_Homo sapiens_hsa040100.13884840
158Estrogen signaling pathway_Homo sapiens_hsa049150.13286603
159Melanogenesis_Homo sapiens_hsa049160.12855023
160Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.12712610
161Ras signaling pathway_Homo sapiens_hsa040140.12332450
162Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.12127505
163Bile secretion_Homo sapiens_hsa049760.11672290
164Choline metabolism in cancer_Homo sapiens_hsa052310.11102893
165Metabolic pathways_Homo sapiens_hsa011000.10980397
166Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.09776837
167Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.09617235
168Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.08329437
169Prion diseases_Homo sapiens_hsa050200.08100459
170Sulfur metabolism_Homo sapiens_hsa009200.07985816

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »