CRHR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a G-protein coupled receptor that binds neuropeptides of the corticotropin releasing hormone family that are major regulators of the hypothalamic-pituitary-adrenal pathway. The encoded protein is essential for the activation of signal transduction pathways that regulate diverse physiological processes including stress, reproduction, immune response and obesity. Alternative splicing results in multiple transcript variants. Naturally-occurring readthrough transcription between this gene and upstream GeneID:147081 results in transcripts that encode isoforms that share similarity with the products of this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)6.37556006
2synaptic vesicle maturation (GO:0016188)5.94966940
3cerebellar granule cell differentiation (GO:0021707)5.86743896
4vocalization behavior (GO:0071625)5.83680016
5glutamate secretion (GO:0014047)5.75936915
6synaptic vesicle docking involved in exocytosis (GO:0016081)5.72130493
7positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.70942138
8synaptic vesicle exocytosis (GO:0016079)5.69721385
9response to pheromone (GO:0019236)5.67341617
10neuronal action potential propagation (GO:0019227)5.66304208
11positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.62565128
12regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.58134730
13regulation of synaptic vesicle exocytosis (GO:2000300)5.33499364
14* locomotory exploration behavior (GO:0035641)5.16497754
15neurotransmitter secretion (GO:0007269)5.04262783
16ionotropic glutamate receptor signaling pathway (GO:0035235)5.00523299
17glutamate receptor signaling pathway (GO:0007215)4.77956808
18regulation of glutamate receptor signaling pathway (GO:1900449)4.76939731
19synaptic transmission, glutamatergic (GO:0035249)4.66974571
20cerebellar Purkinje cell differentiation (GO:0021702)4.62650506
21regulation of synaptic vesicle transport (GO:1902803)4.62349480
22L-amino acid import (GO:0043092)4.61272844
23positive regulation of synapse maturation (GO:0090129)4.60786006
24protein localization to synapse (GO:0035418)4.56807838
25gamma-aminobutyric acid transport (GO:0015812)4.50497594
26cellular potassium ion homeostasis (GO:0030007)4.47115374
27G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.43849527
28neuron cell-cell adhesion (GO:0007158)4.40840039
29neuron-neuron synaptic transmission (GO:0007270)4.33029643
30neurotransmitter-gated ion channel clustering (GO:0072578)4.26276528
31neuronal ion channel clustering (GO:0045161)4.25852531
32gamma-aminobutyric acid signaling pathway (GO:0007214)4.19095658
33regulation of long-term neuronal synaptic plasticity (GO:0048169)4.18060792
34long-term memory (GO:0007616)4.15511285
35amino acid import (GO:0043090)4.12896073
36sodium ion export (GO:0071436)4.10100041
37layer formation in cerebral cortex (GO:0021819)4.09427364
38cell differentiation in hindbrain (GO:0021533)4.06416120
39regulation of excitatory postsynaptic membrane potential (GO:0060079)4.04171164
40dendritic spine organization (GO:0097061)4.04022600
41regulation of neuronal synaptic plasticity (GO:0048168)4.00477923
42positive regulation of membrane potential (GO:0045838)3.95839367
43neurotransmitter transport (GO:0006836)3.95193948
44positive regulation of dendritic spine morphogenesis (GO:0061003)3.90944619
45* regulation of voltage-gated calcium channel activity (GO:1901385)3.88175099
46membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.86827551
47regulation of postsynaptic membrane potential (GO:0060078)3.85440597
48regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.84469172
49positive regulation of dendritic spine development (GO:0060999)3.83828473
50dendritic spine morphogenesis (GO:0060997)3.78353083
51regulation of neurotransmitter levels (GO:0001505)3.78089619
52* exploration behavior (GO:0035640)3.75889731
53synaptic vesicle endocytosis (GO:0048488)3.74229870
54regulation of neurotransmitter secretion (GO:0046928)3.74132123
55auditory behavior (GO:0031223)3.71384110
56regulation of synapse maturation (GO:0090128)3.70311092
57positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.62728907
58activation of protein kinase A activity (GO:0034199)3.62378030
59negative regulation of synaptic transmission, GABAergic (GO:0032229)3.62234688
60regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.59646035
61transmission of nerve impulse (GO:0019226)3.59222758
62neuromuscular process controlling posture (GO:0050884)3.58829527
63neuromuscular process controlling balance (GO:0050885)3.58724926
64postsynaptic membrane organization (GO:0001941)3.56612374
65cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.54349114
66regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.53737025
67regulation of synapse structural plasticity (GO:0051823)3.53378233
68regulation of vesicle fusion (GO:0031338)3.50796014
69positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.50494066
70establishment of mitochondrion localization (GO:0051654)3.49825499
71potassium ion homeostasis (GO:0055075)3.45942078
72positive regulation of neurotransmitter secretion (GO:0001956)3.45864082
73negative regulation of microtubule polymerization (GO:0031115)3.44668507
74negative regulation of dendrite morphogenesis (GO:0050774)3.42631209
75mechanosensory behavior (GO:0007638)3.41765265
76membrane depolarization (GO:0051899)3.41584343
77presynaptic membrane organization (GO:0097090)3.40146263
78membrane depolarization during action potential (GO:0086010)3.39576703
79regulation of neurotransmitter transport (GO:0051588)3.37047500
80proline transport (GO:0015824)3.35453487
81G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.32591601
82* regulation of synaptic plasticity (GO:0048167)3.31548874
83membrane hyperpolarization (GO:0060081)3.31027606
84cell migration in hindbrain (GO:0021535)3.30913919
85presynaptic membrane assembly (GO:0097105)3.29036190
86axon ensheathment in central nervous system (GO:0032291)3.29027542
87central nervous system myelination (GO:0022010)3.29027542
88neuron recognition (GO:0008038)3.28787831
89regulation of synaptic transmission, glutamatergic (GO:0051966)3.28401048
90regulation of ARF protein signal transduction (GO:0032012)3.27181027
91synapse assembly (GO:0007416)3.23361609
92cellular sodium ion homeostasis (GO:0006883)3.22496603
93adult walking behavior (GO:0007628)3.20937484
94cell communication by electrical coupling (GO:0010644)3.20831077
95dendrite morphogenesis (GO:0048813)3.19827063
96regulation of dendritic spine development (GO:0060998)3.14927006
97acidic amino acid transport (GO:0015800)3.14874695
98* long-term synaptic potentiation (GO:0060291)3.14763199
99axonal fasciculation (GO:0007413)3.14742592
100* regulation of synaptic transmission (GO:0050804)3.13046139
101response to auditory stimulus (GO:0010996)3.12645702
102potassium ion import (GO:0010107)3.12623118
103regulation of dendritic spine morphogenesis (GO:0061001)3.12483097
104positive regulation of neurotransmitter transport (GO:0051590)3.11652230
105long term synaptic depression (GO:0060292)3.10648450
106positive regulation of synapse assembly (GO:0051965)3.10345169
107synaptic vesicle transport (GO:0048489)3.09903846
108establishment of synaptic vesicle localization (GO:0097480)3.09903846
109negative regulation of amyloid precursor protein catabolic process (GO:1902992)3.08947903
110innervation (GO:0060384)3.08645180
111glycine transport (GO:0015816)3.07315478
112serotonin metabolic process (GO:0042428)3.06751369
113regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.06101347
114synapse organization (GO:0050808)3.04264450
115neuromuscular process (GO:0050905)3.03787220
116mating behavior (GO:0007617)3.03225886
117synaptic transmission (GO:0007268)3.02979231
118cell communication involved in cardiac conduction (GO:0086065)3.02941850
119regulation of calcium ion-dependent exocytosis (GO:0017158)3.02130401
120mitochondrion transport along microtubule (GO:0047497)3.01842375
121establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.01842375
122cytoskeletal anchoring at plasma membrane (GO:0007016)3.01002794
123intraspecies interaction between organisms (GO:0051703)3.00043299
124calcium ion-dependent exocytosis (GO:0017156)2.97742317
125prepulse inhibition (GO:0060134)2.95017548
126chemosensory behavior (GO:0007635)2.94350959
127neuromuscular synaptic transmission (GO:0007274)2.93206358

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.02770716
2SUZ12_18555785_ChIP-Seq_MESCs_Mouse3.35239186
3GBX2_23144817_ChIP-Seq_PC3_Human3.25862257
4* SUZ12_18692474_ChIP-Seq_MESCs_Mouse3.19786643
5* JARID2_20064375_ChIP-Seq_MESCs_Mouse3.12192240
6* EZH2_18974828_ChIP-Seq_MESCs_Mouse2.89339954
7* RNF2_18974828_ChIP-Seq_MESCs_Mouse2.89339954
8* REST_21632747_ChIP-Seq_MESCs_Mouse2.86118122
9DROSHA_22980978_ChIP-Seq_HELA_Human2.82907559
10* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.67009325
11* MTF2_20144788_ChIP-Seq_MESCs_Mouse2.64268034
12* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.62720466
13* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.60147514
14* SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.59439651
15* SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.59186306
16* EZH2_27294783_Chip-Seq_ESCs_Mouse2.47147138
17IKZF1_21737484_ChIP-ChIP_HCT116_Human2.45217947
18RARB_27405468_Chip-Seq_BRAIN_Mouse2.43366059
19* EZH2_27304074_Chip-Seq_ESCs_Mouse2.42486589
20* EED_16625203_ChIP-ChIP_MESCs_Mouse2.36806815
21* SUZ12_27294783_Chip-Seq_ESCs_Mouse2.35812570
22* REST_18959480_ChIP-ChIP_MESCs_Mouse2.34718477
23* RNF2_27304074_Chip-Seq_ESCs_Mouse2.26919886
24MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.19661446
25TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.16582800
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.13104842
27CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.10633815
28* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.10369180
29GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.97131578
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.91448077
31ERG_21242973_ChIP-ChIP_JURKAT_Human1.88981864
32CTBP2_25329375_ChIP-Seq_LNCAP_Human1.75653215
33SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.57783346
34ZNF274_21170338_ChIP-Seq_K562_Hela1.54338404
35SMAD4_21799915_ChIP-Seq_A2780_Human1.53703190
36AR_21572438_ChIP-Seq_LNCaP_Human1.51532510
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.49258238
38TAF15_26573619_Chip-Seq_HEK293_Human1.39932215
39* RING1B_27294783_Chip-Seq_ESCs_Mouse1.37370211
40DNAJC2_21179169_ChIP-ChIP_NT2_Human1.36667254
41* PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.34287234
42* RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.34240515
43SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.28302726
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27977772
45LXR_22292898_ChIP-Seq_THP-1_Human1.27593429
46SOX2_21211035_ChIP-Seq_LN229_Gbm1.26996169
47* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.24479896
48* AR_19668381_ChIP-Seq_PC3_Human1.23147270
49KDM2B_26808549_Chip-Seq_K562_Human1.22069431
50* RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.20943730
51NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20564492
52GATA1_26923725_Chip-Seq_HPCs_Mouse1.20448524
53ZFP57_27257070_Chip-Seq_ESCs_Mouse1.19852950
54ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.19253860
55* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.19122044
56SMAD3_21741376_ChIP-Seq_EPCs_Human1.17633979
57SRY_22984422_ChIP-ChIP_TESTIS_Rat1.15438666
58CBX2_27304074_Chip-Seq_ESCs_Mouse1.15388825
59AR_25329375_ChIP-Seq_VCAP_Human1.15308220
60TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.14713676
61STAT3_23295773_ChIP-Seq_U87_Human1.13418585
62* RING1B_27294783_Chip-Seq_NPCs_Mouse1.13125475
63* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.12581111
64OCT4_19829295_ChIP-Seq_ESCs_Human1.12257942
65KDM2B_26808549_Chip-Seq_SUP-B15_Human1.11867237
66P300_19829295_ChIP-Seq_ESCs_Human1.11441260
67ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11329979
68* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.09288083
69PIAS1_25552417_ChIP-Seq_VCAP_Human1.09087894
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.08429108
71P53_22127205_ChIP-Seq_FIBROBLAST_Human1.07923530
72TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07262774
73THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.06997968
74TCF4_23295773_ChIP-Seq_U87_Human1.05414120
75ARNT_22903824_ChIP-Seq_MCF-7_Human1.04864525
76ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04538383
77* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.04047077
78ZNF217_24962896_ChIP-Seq_MCF-7_Human1.03747117
79MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02205249
80CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.01178482
81OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01091644
82TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00871681
83POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00871681
84* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00713773
85AHR_22903824_ChIP-Seq_MCF-7_Human1.00588925
86TOP2B_26459242_ChIP-Seq_MCF-7_Human1.00376770
87SMAD3_21741376_ChIP-Seq_ESCs_Human1.00354698
88* GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00241166
89PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.98825203
90RNF2_27304074_Chip-Seq_NSC_Mouse0.98124486
91TET1_21490601_ChIP-Seq_MESCs_Mouse0.95731580
92SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.95327298
93SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.93894514
94RUNX2_22187159_ChIP-Seq_PCA_Human0.93651835
95SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.93607289
96TP53_16413492_ChIP-PET_HCT116_Human0.93214361
97* YAP1_20516196_ChIP-Seq_MESCs_Mouse0.93015133
98* RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.91505547
99ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90151751
100SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.89546321
101TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.89365865
102CREB1_26743006_Chip-Seq_LNCaP_Human0.89295661
103PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.89272632
104P68_20966046_ChIP-Seq_HELA_Human0.88803477
105CDX2_19796622_ChIP-Seq_MESCs_Mouse0.87913116
106MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.87722111
107KLF4_19829295_ChIP-Seq_ESCs_Human0.87349248
108SMC4_20622854_ChIP-Seq_HELA_Human0.87344799
109SMAD4_21741376_ChIP-Seq_HESCs_Human0.87338863
110NR3C1_21868756_ChIP-Seq_MCF10A_Human0.86940974
111PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.86563591
112RXR_22108803_ChIP-Seq_LS180_Human0.85623449
113* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.84826428
114* DPY_21335234_ChIP-Seq_ESCs_Mouse0.84612852
115OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.82641422
116TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.82485389
117* TP53_20018659_ChIP-ChIP_R1E_Mouse0.81280555
118* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.81171172
119AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.80854096
120* SMAD4_21741376_ChIP-Seq_EPCs_Human0.80681952
121CTCF_27219007_Chip-Seq_Bcells_Human0.79829681
122TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.78676262
123KDM2B_26808549_Chip-Seq_DND41_Human0.77171472
124UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.77082217
125TET1_21451524_ChIP-Seq_MESCs_Mouse0.76319918
126SMAD4_21741376_ChIP-Seq_ESCs_Human0.74909955
127EGR1_19032775_ChIP-ChIP_M12_Human0.74521123
128ESR2_21235772_ChIP-Seq_MCF-7_Human0.73110371
129DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.72876801
130SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.71069586
131NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.69594339
132KDM2B_26808549_Chip-Seq_JURKAT_Human0.69306854

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity6.23931625
2MP0003880_abnormal_central_pattern4.44324415
3MP0003635_abnormal_synaptic_transmissio4.21930837
4MP0009046_muscle_twitch4.05623587
5MP0004270_analgesia3.37082367
6* MP0009745_abnormal_behavioral_response3.30153773
7MP0002064_seizures3.24095137
8MP0005423_abnormal_somatic_nervous3.22607800
9* MP0002063_abnormal_learning/memory/cond3.16484758
10MP0001968_abnormal_touch/_nociception2.98664460
11MP0002272_abnormal_nervous_system2.86431833
12* MP0002572_abnormal_emotion/affect_behav2.74728116
13MP0002734_abnormal_mechanical_nocicepti2.69181193
14MP0001486_abnormal_startle_reflex2.58271495
15MP0008569_lethality_at_weaning2.53921047
16MP0002736_abnormal_nociception_after2.35805598
17MP0002067_abnormal_sensory_capabilities2.35288370
18MP0001440_abnormal_grooming_behavior2.33951339
19MP0001501_abnormal_sleep_pattern2.24899584
20MP0003879_abnormal_hair_cell2.24018029
21MP0002735_abnormal_chemical_nociception2.16767078
22MP0002184_abnormal_innervation2.12261443
23MP0009780_abnormal_chondrocyte_physiolo2.09533247
24MP0004145_abnormal_muscle_electrophysio2.00864802
25MP0002733_abnormal_thermal_nociception1.94734501
26MP0003329_amyloid_beta_deposits1.90798538
27MP0001970_abnormal_pain_threshold1.85519363
28MP0002557_abnormal_social/conspecific_i1.81893300
29MP0005386_behavior/neurological_phenoty1.78723370
30MP0004924_abnormal_behavior1.78723370
31MP0000778_abnormal_nervous_system1.68463550
32MP0004811_abnormal_neuron_physiology1.64294791
33MP0004885_abnormal_endolymph1.63882284
34MP0003123_paternal_imprinting1.60647305
35MP0002822_catalepsy1.60000839
36MP0000955_abnormal_spinal_cord1.58042153
37MP0002909_abnormal_adrenal_gland1.57675555
38MP0004142_abnormal_muscle_tone1.56236694
39* MP0002066_abnormal_motor_capabilities/c1.50205222
40MP0001502_abnormal_circadian_rhythm1.48409853
41MP0006276_abnormal_autonomic_nervous1.46722645
42MP0002882_abnormal_neuron_morphology1.42246954
43MP0004858_abnormal_nervous_system1.39476264
44MP0003633_abnormal_nervous_system1.37730626
45MP0001984_abnormal_olfaction1.33492431
46MP0005645_abnormal_hypothalamus_physiol1.32516531
47MP0004742_abnormal_vestibular_system1.26772378
48MP0003631_nervous_system_phenotype1.23016484
49MP0001963_abnormal_hearing_physiology1.21683946
50MP0003787_abnormal_imprinting1.21303142
51MP0003122_maternal_imprinting1.20902666
52MP0001188_hyperpigmentation1.20234846
53MP0001485_abnormal_pinna_reflex1.19119937
54MP0008872_abnormal_physiological_respon1.16058879
55MP0002152_abnormal_brain_morphology1.15025726
56MP0001346_abnormal_lacrimal_gland1.13830098
57MP0005646_abnormal_pituitary_gland1.13291388
58MP0003632_abnormal_nervous_system1.10950853
59MP0000751_myopathy1.06993883
60MP0002229_neurodegeneration1.04894427
61MP0005409_darkened_coat_color1.00373086
62MP0008877_abnormal_DNA_methylation0.99691475
63MP0003283_abnormal_digestive_organ0.98218348
64MP0001905_abnormal_dopamine_level0.98035939
65MP0010234_abnormal_vibrissa_follicle0.97123572
66MP0002638_abnormal_pupillary_reflex0.96896581
67MP0004043_abnormal_pH_regulation0.96792299
68MP0005551_abnormal_eye_electrophysiolog0.89872109
69MP0001348_abnormal_lacrimal_gland0.89319163
70* MP0002069_abnormal_eating/drinking_beha0.88203303
71MP0002249_abnormal_larynx_morphology0.87958883
72MP0001529_abnormal_vocalization0.87811357
73MP0000579_abnormal_nail_morphology0.87713927
74MP0003121_genomic_imprinting0.87408272
75MP0003690_abnormal_glial_cell0.83054938
76MP0002752_abnormal_somatic_nervous0.82532545
77MP0005535_abnormal_body_temperature0.82119192
78MP0000013_abnormal_adipose_tissue0.81680319
79MP0008961_abnormal_basal_metabolism0.80825733
80MP0000604_amyloidosis0.78613036
81MP0006072_abnormal_retinal_apoptosis0.78183034
82MP0000920_abnormal_myelination0.76331094
83MP0008874_decreased_physiological_sensi0.75721224
84MP0004085_abnormal_heartbeat0.75597985
85MP0000026_abnormal_inner_ear0.74731262
86MP0004215_abnormal_myocardial_fiber0.74508113
87MP0000631_abnormal_neuroendocrine_gland0.74013870
88MP0005187_abnormal_penis_morphology0.73142242
89MP0005623_abnormal_meninges_morphology0.72821393
90MP0000569_abnormal_digit_pigmentation0.70166901
91MP0005394_taste/olfaction_phenotype0.69717131
92MP0005499_abnormal_olfactory_system0.69717131
93MP0003634_abnormal_glial_cell0.69678725
94MP0004510_myositis0.68605900
95MP0003137_abnormal_impulse_conducting0.67539522
96MP0000566_synostosis0.67135700
97MP0001299_abnormal_eye_distance/0.66584940
98MP0004147_increased_porphyrin_level0.65406399
99MP0001177_atelectasis0.64118390
100MP0001986_abnormal_taste_sensitivity0.63382735
101MP0002234_abnormal_pharynx_morphology0.63102561
102MP0004484_altered_response_of0.63023285
103MP0010769_abnormal_survival0.62061430
104MP0002837_dystrophic_cardiac_calcinosis0.61638964
105MP0003183_abnormal_peptide_metabolism0.61379746
106MP0004130_abnormal_muscle_cell0.60298752
107MP0002082_postnatal_lethality0.59723274
108MP0010770_preweaning_lethality0.59723274
109MP0002089_abnormal_postnatal_growth/wei0.59343026
110MP0010768_mortality/aging0.58649307
111MP0002653_abnormal_ependyma_morphology0.58561688
112MP0003861_abnormal_nervous_system0.56841346
113* MP0001943_abnormal_respiration0.56587865
114MP0005167_abnormal_blood-brain_barrier0.55737883
115MP0010386_abnormal_urinary_bladder0.55318118
116MP0002090_abnormal_vision0.54180590
117MP0003956_abnormal_body_size0.52640446
118MP0003938_abnormal_ear_development0.50800318

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)7.56325696
2Visual hallucinations (HP:0002367)6.24653281
3Myokymia (HP:0002411)5.97471436
4Focal seizures (HP:0007359)5.82860447
5Progressive cerebellar ataxia (HP:0002073)5.67603817
6Atonic seizures (HP:0010819)5.40986830
7Action tremor (HP:0002345)5.19870886
8Epileptic encephalopathy (HP:0200134)5.13974262
9Febrile seizures (HP:0002373)4.70405266
10Absence seizures (HP:0002121)4.49957500
11Gaze-evoked nystagmus (HP:0000640)4.39623127
12Broad-based gait (HP:0002136)4.27352258
13Dialeptic seizures (HP:0011146)3.93336738
14Obstructive sleep apnea (HP:0002870)3.90381318
15Dysdiadochokinesis (HP:0002075)3.80916007
16Generalized tonic-clonic seizures (HP:0002069)3.80885219
17Impaired smooth pursuit (HP:0007772)3.69448064
18Poor eye contact (HP:0000817)3.63603150
19Scanning speech (HP:0002168)3.58778113
20Abnormality of the lower motor neuron (HP:0002366)3.48086037
21Cerebral hypomyelination (HP:0006808)3.47478169
22Genetic anticipation (HP:0003743)3.42917998
23Dysmetria (HP:0001310)3.42563933
24Dysmetric saccades (HP:0000641)3.36346110
25Abnormality of ocular smooth pursuit (HP:0000617)3.31197003
26Hemiplegia (HP:0002301)3.29291501
27Truncal ataxia (HP:0002078)3.27467680
28Hyperventilation (HP:0002883)3.26597822
29Supranuclear gaze palsy (HP:0000605)3.25433737
30Impaired social interactions (HP:0000735)3.21915293
31Abnormal social behavior (HP:0012433)3.21915293
32Hemiparesis (HP:0001269)3.09841602
33Intention tremor (HP:0002080)3.08715352
34Depression (HP:0000716)3.07380593
35Diplopia (HP:0000651)3.03561424
36Abnormality of binocular vision (HP:0011514)3.03561424
37Peripheral hypomyelination (HP:0007182)2.99783840
38Impaired vibration sensation in the lower limbs (HP:0002166)2.99697596
39Abnormal eating behavior (HP:0100738)2.96310999
40Status epilepticus (HP:0002133)2.93761953
41Anxiety (HP:0000739)2.88873153
42Delusions (HP:0000746)2.86277708
43Ankle clonus (HP:0011448)2.71872231
44Sleep apnea (HP:0010535)2.71646834
45Amblyopia (HP:0000646)2.66282130
46Postural instability (HP:0002172)2.64059689
47Mutism (HP:0002300)2.59893711
48Akinesia (HP:0002304)2.55756807
49Ventricular fibrillation (HP:0001663)2.55369904
50Urinary bladder sphincter dysfunction (HP:0002839)2.52599632
51Agitation (HP:0000713)2.51162380
52Excessive salivation (HP:0003781)2.49866601
53Drooling (HP:0002307)2.49866601
54Craniofacial dystonia (HP:0012179)2.47901798
55Apathy (HP:0000741)2.46158487
56Abnormality of the corticospinal tract (HP:0002492)2.43032745
57Stereotypic behavior (HP:0000733)2.41255044
58Abnormality of saccadic eye movements (HP:0000570)2.41159740
59Amyotrophic lateral sclerosis (HP:0007354)2.40384388
60Spastic gait (HP:0002064)2.40252624
61Epileptiform EEG discharges (HP:0011182)2.39107596
62Limb dystonia (HP:0002451)2.37616590
63Postural tremor (HP:0002174)2.35613502
64Spastic tetraparesis (HP:0001285)2.29473895
65EEG with generalized epileptiform discharges (HP:0011198)2.28291056
66Gait ataxia (HP:0002066)2.26911162
67Annular pancreas (HP:0001734)2.23554613
68CNS hypomyelination (HP:0003429)2.21260834
69Hand muscle atrophy (HP:0009130)2.20910314
70Cerebral inclusion bodies (HP:0100314)2.20311851
71Urinary urgency (HP:0000012)2.19241403
72Papilledema (HP:0001085)2.19122732
73Tetraplegia (HP:0002445)2.18683321
74Diminished motivation (HP:0000745)2.18595226
75Pheochromocytoma (HP:0002666)2.18170620
76Bradykinesia (HP:0002067)2.16933642
77Hypsarrhythmia (HP:0002521)2.16883868
78Mixed hearing impairment (HP:0000410)2.15939876
79Limb ataxia (HP:0002070)2.15906906
80Fetal akinesia sequence (HP:0001989)2.13979405
81Psychosis (HP:0000709)2.13562132
82Impaired vibratory sensation (HP:0002495)2.13498598
83Bundle branch block (HP:0011710)2.09762611
84Lower limb asymmetry (HP:0100559)2.09270854
85Progressive inability to walk (HP:0002505)2.04775258
86Neurofibrillary tangles (HP:0002185)2.04257922
87Torticollis (HP:0000473)2.04140497
88Neuronal loss in central nervous system (HP:0002529)2.03573024
89Rapidly progressive (HP:0003678)2.01123885
90Horizontal nystagmus (HP:0000666)1.99526362
91Pointed chin (HP:0000307)1.96972749
92Hypoventilation (HP:0002791)1.96672907
93Upper limb amyotrophy (HP:0009129)1.95763381
94Distal upper limb amyotrophy (HP:0007149)1.95763381
95Absent speech (HP:0001344)1.94362693
96Morphological abnormality of the pyramidal tract (HP:0002062)1.94250966
97Focal dystonia (HP:0004373)1.93550716
98Spastic tetraplegia (HP:0002510)1.91286789
99Incomplete penetrance (HP:0003829)1.91188383
100Polyphagia (HP:0002591)1.90466579
101Insomnia (HP:0100785)1.90415812
102Insidious onset (HP:0003587)1.89309226
103Termporal pattern (HP:0011008)1.89309226
104Megalencephaly (HP:0001355)1.87312396
105Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.87181793
106Myotonia (HP:0002486)1.86539106
107Split foot (HP:0001839)1.84768310
108Spinal canal stenosis (HP:0003416)1.84314046
109Generalized myoclonic seizures (HP:0002123)1.82733763
110Failure to thrive in infancy (HP:0001531)1.82231772
111Clonus (HP:0002169)1.80430868
112Choreoathetosis (HP:0001266)1.79068992
113Inability to walk (HP:0002540)1.75416081
114Degeneration of the lateral corticospinal tracts (HP:0002314)1.75219080
115Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.75219080
116Neuroendocrine neoplasm (HP:0100634)1.74387719
117Lower limb muscle weakness (HP:0007340)1.73855675
118Narrow nasal bridge (HP:0000446)1.69303525
119Rigidity (HP:0002063)1.68004137
120Protruding tongue (HP:0010808)1.67490632

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.84661845
2DAPK23.45625328
3MAP3K93.26155376
4MAP3K43.23034486
5EPHA43.19022515
6CASK2.81096325
7MAP2K72.68384129
8MARK12.64065713
9CAMKK22.56460342
10MINK12.47048809
11PAK62.30312266
12CDK192.27213718
13CAMKK12.15595670
14MAP2K42.15496377
15NTRK22.11870966
16MAP3K121.89672070
17DAPK11.78926733
18RIPK41.76050298
19MUSK1.74114406
20MAPK151.65825211
21PLK21.63839220
22RIPK11.58623888
23GRK51.50644384
24STK381.50555632
25KSR21.46008734
26CDK51.44861467
27PNCK1.42359630
28UHMK11.40474648
29MAPK131.35996024
30PRKCG1.35828415
31SIK21.32903774
32WNK11.32517333
33PRKD31.31874819
34NEK61.28836788
35NTRK11.26260297
36DDR21.24533700
37KSR11.22918298
38OXSR11.18908882
39TYRO31.16300801
40PRPF4B1.14684479
41CCNB11.10129054
42TNIK1.06484386
43STK111.05385610
44CDK151.03621262
45CDK181.03318893
46SGK2231.02133460
47SGK4941.02133460
48CAMK11.01403073
49TESK10.99433681
50ARAF0.98513062
51BRAF0.98016991
52ALK0.95918410
53CAMK2A0.95099217
54CDK140.93476867
55PRKCH0.92452720
56MAP3K20.91706630
57CDK11A0.90572601
58PHKG10.90013784
59PHKG20.90013784
60CAMK2B0.89358362
61SGK20.89199143
62MAPKAPK50.87865403
63MAP3K60.86917445
64CDC42BPA0.85396763
65BRSK10.84270311
66RET0.84186746
67PKN10.82502846
68DYRK1A0.78395007
69MAP3K130.76786312
70TAOK10.76462275
71SGK30.76294306
72FES0.72595492
73PTK2B0.71589154
74SGK10.70461422
75CAMK2G0.69715061
76CAMK40.68997423
77CAMK1G0.68392631
78DAPK30.65376919
79MARK20.64385497
80CSNK1G20.63537885
81MAP3K110.62551620
82PAK30.62082996
83MAP2K60.61618517
84BMPR20.61530492
85PDK10.60984316
86CAMK2D0.58128531
87CSNK1A1L0.57782473
88PINK10.57495163
89PDPK10.54259716
90CSNK1G30.52413117
91ROCK20.50617495
92LIMK10.48220619
93RPS6KA30.48194934
94AKT30.47927597
95MAPK120.47842108
96FYN0.46135220
97ICK0.44475615
98BMPR1B0.42230694
99PRKCZ0.41444019
100SCYL20.41092731
101SIK10.40983217
102LATS20.40713496
103PRKCE0.39812347
104TNK20.39704348
105RAF10.36894378
106ERBB20.35426443
107IRAK20.34995240
108PTK20.34735814
109LMTK20.34342309
110MAP3K10.33937378
111MAPK80.33320467
112MAPK100.32955468
113DYRK20.32725017
114PRKG10.32625538
115PRKCB0.32295882
116CSNK1E0.30370794
117NME10.30090174
118PRKCA0.29841430
119FGR0.29739819
120RPS6KA20.29473603
121SIK30.29444727
122CSNK1D0.26439709
123PRKAA10.23877827
124FGFR20.23565594
125* PRKACA0.23483073

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.03762715
2Synaptic vesicle cycle_Homo sapiens_hsa047213.48628145
3Long-term potentiation_Homo sapiens_hsa047202.92321884
4Glutamatergic synapse_Homo sapiens_hsa047242.83488459
5Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.82955592
6Circadian entrainment_Homo sapiens_hsa047132.73605017
7GABAergic synapse_Homo sapiens_hsa047272.61362453
8Amphetamine addiction_Homo sapiens_hsa050312.58656533
9Morphine addiction_Homo sapiens_hsa050322.45517991
10Olfactory transduction_Homo sapiens_hsa047402.28433303
11Salivary secretion_Homo sapiens_hsa049702.25352168
12Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.22474000
13Taste transduction_Homo sapiens_hsa047422.19542363
14Dopaminergic synapse_Homo sapiens_hsa047282.13956144
15Insulin secretion_Homo sapiens_hsa049112.09499500
16Gastric acid secretion_Homo sapiens_hsa049711.98540914
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.94962571
18* Long-term depression_Homo sapiens_hsa047301.90909768
19Cholinergic synapse_Homo sapiens_hsa047251.82053221
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.68604888
21Oxytocin signaling pathway_Homo sapiens_hsa049211.61917090
22Cocaine addiction_Homo sapiens_hsa050301.60350366
23Collecting duct acid secretion_Homo sapiens_hsa049661.55003045
24Renin secretion_Homo sapiens_hsa049241.54860010
25Calcium signaling pathway_Homo sapiens_hsa040201.54023942
26Serotonergic synapse_Homo sapiens_hsa047261.50670937
27Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50145789
28GnRH signaling pathway_Homo sapiens_hsa049121.42344611
29Type II diabetes mellitus_Homo sapiens_hsa049301.41556266
30Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.36041876
31Vitamin B6 metabolism_Homo sapiens_hsa007501.35521800
32Phosphatidylinositol signaling system_Homo sapiens_hsa040701.35235233
33Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.32837934
34Gap junction_Homo sapiens_hsa045401.31880916
35Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.29205529
36cAMP signaling pathway_Homo sapiens_hsa040241.25410744
37Estrogen signaling pathway_Homo sapiens_hsa049151.22939930
38Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.10922339
39Cardiac muscle contraction_Homo sapiens_hsa042601.08840728
40Pancreatic secretion_Homo sapiens_hsa049721.05494752
41Melanogenesis_Homo sapiens_hsa049161.02264719
42Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.01768537
43cGMP-PKG signaling pathway_Homo sapiens_hsa040221.01760529
44Axon guidance_Homo sapiens_hsa043600.96326046
45Thyroid hormone synthesis_Homo sapiens_hsa049180.96080870
46Vibrio cholerae infection_Homo sapiens_hsa051100.93227544
47Glioma_Homo sapiens_hsa052140.89192243
48ErbB signaling pathway_Homo sapiens_hsa040120.88732598
49Carbohydrate digestion and absorption_Homo sapiens_hsa049730.87775184
50* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.84582111
51Vascular smooth muscle contraction_Homo sapiens_hsa042700.83751214
52Oocyte meiosis_Homo sapiens_hsa041140.82918103
53Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.80471694
54Dorso-ventral axis formation_Homo sapiens_hsa043200.78389295
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.76542237
56Phospholipase D signaling pathway_Homo sapiens_hsa040720.76488828
57Nitrogen metabolism_Homo sapiens_hsa009100.76279166
58Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.75027630
59Dilated cardiomyopathy_Homo sapiens_hsa054140.72702147
60Circadian rhythm_Homo sapiens_hsa047100.71151942
61MAPK signaling pathway_Homo sapiens_hsa040100.68828596
62Inositol phosphate metabolism_Homo sapiens_hsa005620.68261176
63Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66374264
64Phototransduction_Homo sapiens_hsa047440.65724583
65Bile secretion_Homo sapiens_hsa049760.60127750
66Choline metabolism in cancer_Homo sapiens_hsa052310.59019919
67Neurotrophin signaling pathway_Homo sapiens_hsa047220.58190874
68Glucagon signaling pathway_Homo sapiens_hsa049220.56727162
69Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.56080676
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51466520
71Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.48657318
72Alzheimers disease_Homo sapiens_hsa050100.48525593
73VEGF signaling pathway_Homo sapiens_hsa043700.48402109
74Hippo signaling pathway_Homo sapiens_hsa043900.47988707
75Alcoholism_Homo sapiens_hsa050340.46618370
76Thyroid hormone signaling pathway_Homo sapiens_hsa049190.46503374
77Longevity regulating pathway - mammal_Homo sapiens_hsa042110.44007914
78Rap1 signaling pathway_Homo sapiens_hsa040150.42607141
79mTOR signaling pathway_Homo sapiens_hsa041500.42546763
80Sphingolipid signaling pathway_Homo sapiens_hsa040710.41277249
81Ras signaling pathway_Homo sapiens_hsa040140.40952733
82Arginine biosynthesis_Homo sapiens_hsa002200.40711411
83Arginine and proline metabolism_Homo sapiens_hsa003300.40215399
84Ovarian steroidogenesis_Homo sapiens_hsa049130.38929261
85Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.38022286
86SNARE interactions in vesicular transport_Homo sapiens_hsa041300.37931537
87Endocytosis_Homo sapiens_hsa041440.37877609
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.37480012
89Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.36654834
90Wnt signaling pathway_Homo sapiens_hsa043100.35827392
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.34724620
92AMPK signaling pathway_Homo sapiens_hsa041520.32487265
93Renal cell carcinoma_Homo sapiens_hsa052110.31880611
94Insulin signaling pathway_Homo sapiens_hsa049100.31676584
95Regulation of autophagy_Homo sapiens_hsa041400.31316746
96Chemokine signaling pathway_Homo sapiens_hsa040620.28713334
97Fatty acid biosynthesis_Homo sapiens_hsa000610.28321126
98Endometrial cancer_Homo sapiens_hsa052130.26378494
99Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.26362467
100Tight junction_Homo sapiens_hsa045300.26216813
101Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.26052115
102Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.26020904
103Non-small cell lung cancer_Homo sapiens_hsa052230.25692697
104Prion diseases_Homo sapiens_hsa050200.25334070
105African trypanosomiasis_Homo sapiens_hsa051430.22595273
106Type I diabetes mellitus_Homo sapiens_hsa049400.21557154
107Glycerophospholipid metabolism_Homo sapiens_hsa005640.21019645
108Prolactin signaling pathway_Homo sapiens_hsa049170.20224874
109Histidine metabolism_Homo sapiens_hsa003400.19923319
110Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18184684
111Notch signaling pathway_Homo sapiens_hsa043300.17890295

Most similar genes based on co-expression Upload to Enrichr

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