CRIM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a transmembrane protein containing six cysteine-rich repeat domains and an insulin-like growth factor-binding domain. The encoded protein may play a role in tissue development though interactions with members of the transforming growth factor beta family, such as bone morphogenetic proteins. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1blood vessel maturation (GO:0001955)4.01075106
2glomerular visceral epithelial cell development (GO:0072015)3.96215588
3glomerular basement membrane development (GO:0032836)3.86214321
4cell adhesion mediated by integrin (GO:0033627)3.67904236
5cell migration involved in heart development (GO:0060973)3.60679781
6chondrocyte proliferation (GO:0035988)3.58767729
7sprouting angiogenesis (GO:0002040)3.57849337
8glomerular epithelial cell development (GO:0072310)3.57555554
9cellular response to vitamin (GO:0071295)3.43755023
10type B pancreatic cell proliferation (GO:0044342)3.40376859
11axon extension involved in axon guidance (GO:0048846)3.36772093
12neuron projection extension involved in neuron projection guidance (GO:1902284)3.36772093
13plasma membrane repair (GO:0001778)3.35935896
14mesenchymal-epithelial cell signaling (GO:0060638)3.34122268
15negative regulation of chondrocyte differentiation (GO:0032331)3.33080917
16positive regulation of osteoblast proliferation (GO:0033690)3.30530937
17regulation of plasminogen activation (GO:0010755)3.27128366
18retina vasculature morphogenesis in camera-type eye (GO:0061299)3.19086525
19heparan sulfate proteoglycan biosynthetic process (GO:0015012)3.18880481
20bone trabecula formation (GO:0060346)3.16456591
21regulation of branching involved in salivary gland morphogenesis (GO:0060693)3.14647176
22extracellular matrix assembly (GO:0085029)3.12796852
23cytoskeletal anchoring at plasma membrane (GO:0007016)3.12432924
24Golgi transport vesicle coating (GO:0048200)3.11426134
25COPI coating of Golgi vesicle (GO:0048205)3.11426134
26regulation of transforming growth factor beta1 production (GO:0032908)3.09792404
27actin filament depolymerization (GO:0030042)3.08122257
28neuron remodeling (GO:0016322)3.05650951
29endothelium development (GO:0003158)3.04156801
30stress fiber assembly (GO:0043149)3.04123825
31positive regulation of endothelial cell migration (GO:0010595)3.02377154
32hypotonic response (GO:0006971)3.01078749
33cellular response to vitamin D (GO:0071305)3.00444267
34collagen fibril organization (GO:0030199)3.00093380
35cartilage development involved in endochondral bone morphogenesis (GO:0060351)2.98549858
36cell migration involved in sprouting angiogenesis (GO:0002042)2.97723024
37regulation of axon extension involved in axon guidance (GO:0048841)2.96790809
38venous blood vessel morphogenesis (GO:0048845)2.95533090
39regulation of axon guidance (GO:1902667)2.90422827
40protein localization to cell surface (GO:0034394)2.89792673
41extracellular matrix disassembly (GO:0022617)2.89043237
42pericardium development (GO:0060039)2.87888715
43renal filtration (GO:0097205)2.87002127
44negative regulation of smooth muscle cell migration (GO:0014912)2.86932016
45membrane raft organization (GO:0031579)2.83308649
46vascular endothelial growth factor signaling pathway (GO:0038084)2.83307567
47positive regulation of cartilage development (GO:0061036)2.82639297
48hemidesmosome assembly (GO:0031581)2.82575000
49negative regulation of nitric-oxide synthase activity (GO:0051001)2.80225164
50multicellular organismal metabolic process (GO:0044236)2.79768834
51positive regulation of epithelial cell migration (GO:0010634)2.79090952
52regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)2.76762510
53extracellular matrix organization (GO:0030198)2.74142811
54maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.73910275
55extracellular structure organization (GO:0043062)2.73130346
56lymphangiogenesis (GO:0001946)2.72385227
57protein retention in ER lumen (GO:0006621)2.72302977
58extracellular fibril organization (GO:0043206)2.72251240
59smooth muscle tissue development (GO:0048745)2.71788627
60cell-substrate junction assembly (GO:0007044)2.71593745
61hyaluronan catabolic process (GO:0030214)2.69811886
62response to magnesium ion (GO:0032026)2.69648255
63paraxial mesoderm development (GO:0048339)2.68584178
64artery development (GO:0060840)2.67760260
65lens fiber cell development (GO:0070307)2.66894592
66multicellular organismal catabolic process (GO:0044243)2.66682212
67protein hydroxylation (GO:0018126)2.66455072
68regulation of osteoblast proliferation (GO:0033688)2.65977053
69negative regulation of anoikis (GO:2000811)2.64020482
70protein localization to endosome (GO:0036010)2.62929136
71positive regulation of endothelial cell apoptotic process (GO:2000353)2.61507761
72mesodermal cell differentiation (GO:0048333)2.59917840
73epithelial cell-cell adhesion (GO:0090136)2.59640995
74regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.59165846
75adherens junction assembly (GO:0034333)2.58689316
76basement membrane organization (GO:0071711)2.58469170
77positive regulation of fibroblast migration (GO:0010763)2.56174249
78endodermal cell differentiation (GO:0035987)2.55916644
79axon extension (GO:0048675)2.55574777
80branching involved in salivary gland morphogenesis (GO:0060445)2.54630197
81wound healing, spreading of epidermal cells (GO:0035313)2.54327835
82sequestering of extracellular ligand from receptor (GO:0035581)2.50661249
83metanephric nephron epithelium development (GO:0072243)2.50210939
84axonal fasciculation (GO:0007413)2.48388860
85layer formation in cerebral cortex (GO:0021819)2.48002090
86metanephric mesenchyme development (GO:0072075)2.46843238
87positive regulation of axon extension (GO:0045773)2.46692761
88hippo signaling (GO:0035329)2.45940330
89endocardial cushion development (GO:0003197)2.45004909
90lymph vessel development (GO:0001945)2.44739231
91substrate-dependent cell migration (GO:0006929)2.44606413
92negative regulation of fatty acid transport (GO:2000192)2.42987317
93negative regulation of axon extension involved in axon guidance (GO:0048843)2.42676137
94negative regulation of axon guidance (GO:1902668)2.42673741
95metanephric epithelium development (GO:0072207)2.42599509
96dendritic spine morphogenesis (GO:0060997)2.42392585
97negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.41414782
98neuron recognition (GO:0008038)2.40680225
99kidney mesenchyme development (GO:0072074)2.39738044
100blood vessel endothelial cell migration (GO:0043534)2.36732589
101glomerular filtration (GO:0003094)2.35943276
102metanephric nephron tubule development (GO:0072234)2.34113448
103metanephric tubule development (GO:0072170)2.34113448
104establishment of nucleus localization (GO:0040023)2.33362220
105vocalization behavior (GO:0071625)2.32917164
106regulation of glomerular filtration (GO:0003093)2.32503380
107locomotory exploration behavior (GO:0035641)2.31372102
108negative regulation of catenin import into nucleus (GO:0035414)2.31110581
109protein targeting to plasma membrane (GO:0072661)2.30376223
110regulation of tight junction assembly (GO:2000810)2.27857126
111desmosome organization (GO:0002934)2.25772371
112cell-substrate adherens junction assembly (GO:0007045)2.24960058
113focal adhesion assembly (GO:0048041)2.24960058
114regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.24492163
115atrioventricular valve morphogenesis (GO:0003181)2.20196305
116vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.19468636
117substrate adhesion-dependent cell spreading (GO:0034446)2.19108709
118semaphorin-plexin signaling pathway (GO:0071526)2.18673142
119skin morphogenesis (GO:0043589)2.17895685
120camera-type eye morphogenesis (GO:0048593)2.17595658
121protein heterotrimerization (GO:0070208)2.17377160
122neuron projection extension (GO:1990138)2.17327822
123adherens junction organization (GO:0034332)2.14295592
124glomerulus development (GO:0032835)2.14087330
125dendrite morphogenesis (GO:0048813)2.13407915
126apoptotic cell clearance (GO:0043277)2.10119715
127positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)2.09425179
128lens development in camera-type eye (GO:0002088)2.07970460
129endothelial cell morphogenesis (GO:0001886)2.07034216
130polarized epithelial cell differentiation (GO:0030859)2.06199316
131dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.05643752
132cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.05159824
133wound healing, spreading of cells (GO:0044319)2.03810798
134negative regulation of vascular permeability (GO:0043116)2.02197200
135multicellular organismal macromolecule metabolic process (GO:0044259)2.02028986
136regulation of p38MAPK cascade (GO:1900744)2.01310296
137collagen metabolic process (GO:0032963)2.00668390
138cell communication by electrical coupling (GO:0010644)2.00408736
139cell communication by electrical coupling involved in cardiac conduction (GO:0086064)1.99807690
140sodium ion export (GO:0071436)1.98805639
141dendritic spine organization (GO:0097061)1.98288392
142collagen catabolic process (GO:0030574)1.98150564
143activation of protein kinase A activity (GO:0034199)1.97493604
144positive regulation of blood vessel endothelial cell migration (GO:0043536)1.97422202
145chondrocyte development (GO:0002063)1.97206364
146synaptic vesicle maturation (GO:0016188)1.97203917

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human3.37665720
2TP63_17297297_ChIP-ChIP_HaCaT_Human2.72381382
3EZH2_22144423_ChIP-Seq_EOC_Human2.51931905
4* SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.42275003
5RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31695732
6EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31695732
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.23114489
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.19421499
9SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.18063963
10SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.17541911
11EED_16625203_ChIP-ChIP_MESCs_Mouse2.11601595
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.10608432
13CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse2.07969978
14GBX2_23144817_ChIP-Seq_PC3_Human1.97982370
15HIF1A_21447827_ChIP-Seq_MCF-7_Human1.97522638
16EP300_21415370_ChIP-Seq_HL-1_Mouse1.97480400
17CDX2_19796622_ChIP-Seq_MESCs_Mouse1.95877227
18* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.94726130
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.94344272
20RARG_19884340_ChIP-ChIP_MEFs_Mouse1.94292706
21SMAD_19615063_ChIP-ChIP_OVARY_Human1.87257984
22ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.85087662
23EZH2_27304074_Chip-Seq_ESCs_Mouse1.84475288
24* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.83413416
25* ELK3_25401928_ChIP-Seq_HUVEC_Human1.81596404
26TP53_16413492_ChIP-PET_HCT116_Human1.74291216
27* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.72517002
28JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.69097096
29* RNF2_27304074_Chip-Seq_ESCs_Mouse1.67773162
30SALL4_18804426_ChIP-ChIP_XEN_Mouse1.64237489
31SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.62730078
32* WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.62642230
33* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.62258995
34* P300_27058665_Chip-Seq_ZR-75-30cells_Human1.60507820
35CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.59768305
36DROSHA_22980978_ChIP-Seq_HELA_Human1.59597823
37ESR2_21235772_ChIP-Seq_MCF-7_Human1.58555455
38UBF1/2_26484160_Chip-Seq_HMECs_Human1.57933353
39AR_21572438_ChIP-Seq_LNCaP_Human1.55972985
40CJUN_26792858_Chip-Seq_BT549_Human1.55418394
41JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.55221755
42TP53_18474530_ChIP-ChIP_U2OS_Human1.54391082
43GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.53998173
44* EZH2_27294783_Chip-Seq_ESCs_Mouse1.52237150
45SUZ12_27294783_Chip-Seq_ESCs_Mouse1.52119622
46TP53_22127205_ChIP-Seq_IMR90_Human1.48558895
47EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.47579819
48WT1_19549856_ChIP-ChIP_CCG9911_Human1.45647851
49* TBX20_22328084_ChIP-Seq_HEART_Mouse1.43572644
50* TBX20_22080862_ChIP-Seq_HEART_Mouse1.43572644
51PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.41353153
52ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.40201586
53CLOCK_20551151_ChIP-Seq_293T_Human1.40192595
54AHR_22903824_ChIP-Seq_MCF-7_Human1.39547206
55RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.37826273
56* NRF2_20460467_ChIP-Seq_MEFs_Mouse1.36183821
57* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.36183821
58MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.35968704
59STAT6_21828071_ChIP-Seq_BEAS2B_Human1.33795914
60ARNT_22903824_ChIP-Seq_MCF-7_Human1.33276501
61ESR1_20079471_ChIP-ChIP_T-47D_Human1.30400068
62* SMC1_22415368_ChIP-Seq_MEFs_Mouse1.30115820
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.30000147
64PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28737067
65* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.28324219
66* PPAR_26484153_Chip-Seq_NCI-H1993_Human1.27689000
67ESR1_21235772_ChIP-Seq_MCF-7_Human1.27044192
68TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.25994404
69NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.23073623
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.22899817
71NFIB_24661679_ChIP-Seq_LUNG_Mouse1.22577574
72* TP53_23651856_ChIP-Seq_MEFs_Mouse1.21843300
73PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.21598541
74KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.21390606
75SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20851662
76NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.20636870
77NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.19402091
78NR3C1_23031785_ChIP-Seq_PC12_Mouse1.18852461
79TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.16561071
80* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.16303068
81SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.16205689
82GATA2_21666600_ChIP-Seq_HMVEC_Human1.16085943
83RXR_22108803_ChIP-Seq_LS180_Human1.15983716
84TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.15800458
85EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.14909291
86SMAD4_21799915_ChIP-Seq_A2780_Human1.14693189
87AR_21909140_ChIP-Seq_LNCAP_Human1.13986313
88* TP53_20018659_ChIP-ChIP_R1E_Mouse1.13468667
89RING1B_27294783_Chip-Seq_ESCs_Mouse1.11231546
90* PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.10161230
91ZNF263_19887448_ChIP-Seq_K562_Human1.09641866
92SMAD3_21741376_ChIP-Seq_HESCs_Human1.09196008
93BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08475167
94RING1B_27294783_Chip-Seq_NPCs_Mouse1.08435792
95TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.08350392
96BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.08057091
97* SA1_22415368_ChIP-Seq_MEFs_Mouse1.08019086
98* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.07612625
99TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.06581523
100* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.06481778
101RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.06357013
102KDM2B_26808549_Chip-Seq_K562_Human1.06022534
103UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.06011635
104FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.05959488
105DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.05547214
106P63_26484246_Chip-Seq_KERATINOCYTES_Human1.03771968
107TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.03123984
108* FOXO3_23340844_ChIP-Seq_DLD1_Human1.02619842
109EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02502670
110TP63_23658742_ChIP-Seq_EP156T_Human1.02205626
111HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.02179380
112Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01633104
113* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01272304
114ATF3_27146783_Chip-Seq_COLON_Human1.00944362
115IKZF1_21737484_ChIP-ChIP_HCT116_Human1.00559442
116KDM2B_26808549_Chip-Seq_SUP-B15_Human1.00249234
117* BCAT_22108803_ChIP-Seq_LS180_Human0.99086160
118* TCF4_18268006_ChIP-ChIP_LS174T_Human0.99039315
119ERG_21242973_ChIP-ChIP_JURKAT_Human0.98722725
120* SMAD3_21741376_ChIP-Seq_EPCs_Human0.98490571
121NR3C1_21868756_ChIP-Seq_MCF10A_Human0.97862213
122* SMAD4_21741376_ChIP-Seq_HESCs_Human0.97494365
123* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.97115280
124* SMC3_22415368_ChIP-Seq_MEFs_Mouse0.97083404
125RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.96489728
126ISL1_27105846_Chip-Seq_CPCs_Mouse0.96273595
127TOP2B_26459242_ChIP-Seq_MCF-7_Human0.95891532
128* SOX2_21211035_ChIP-Seq_LN229_Gbm0.95574374
129SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.95183810
130CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95081018
131THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91923091
132CTBP2_25329375_ChIP-Seq_LNCAP_Human0.91494614
133* ZNF274_21170338_ChIP-Seq_K562_Hela0.90934563
134CBX2_27304074_Chip-Seq_ESCs_Mouse0.90678104
135* BRD4_25478319_ChIP-Seq_HGPS_Human0.90493583
136* SOX2_20726797_ChIP-Seq_SW620_Human0.90142067
137CTBP1_25329375_ChIP-Seq_LNCAP_Human0.89253008
138* PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.88599426
139POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.88286365
140* AR_25329375_ChIP-Seq_VCAP_Human0.88079832
141* AR_19668381_ChIP-Seq_PC3_Human0.87809426
142* SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.87577526
143* SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.87577526
144EGR1_19374776_ChIP-ChIP_THP-1_Human0.87043042

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005623_abnormal_meninges_morphology4.20923329
2MP0008438_abnormal_cutaneous_collagen3.89837465
3MP0004272_abnormal_basement_membrane3.77484599
4MP0005275_abnormal_skin_tensile2.79147312
5MP0009384_cardiac_valve_regurgitation2.74125774
6MP0004859_abnormal_synaptic_plasticity2.65457063
7MP0003705_abnormal_hypodermis_morpholog2.59754175
8MP0001958_emphysema2.56044500
9MP0003279_aneurysm2.53701552
10MP0010368_abnormal_lymphatic_system2.32572788
11MP0005503_abnormal_tendon_morphology2.21948465
12MP0003566_abnormal_cell_adhesion2.14281985
13MP0003091_abnormal_cell_migration2.09425501
14MP0009780_abnormal_chondrocyte_physiolo1.97901406
15MP0010030_abnormal_orbit_morphology1.89287566
16MP0000537_abnormal_urethra_morphology1.83536766
17MP0001542_abnormal_bone_strength1.81067364
18MP0000751_myopathy1.80194278
19MP0000013_abnormal_adipose_tissue1.74738668
20MP0002295_abnormal_pulmonary_circulatio1.71651192
21MP0001879_abnormal_lymphatic_vessel1.67928669
22MP0004084_abnormal_cardiac_muscle1.66592951
23MP0002697_abnormal_eye_size1.58548209
24MP0006138_congestive_heart_failure1.51861565
25MP0001299_abnormal_eye_distance/1.45497444
26MP0003045_fibrosis1.44962475
27MP0003385_abnormal_body_wall1.42757704
28MP0003635_abnormal_synaptic_transmissio1.37025757
29MP0002108_abnormal_muscle_morphology1.35773491
30MP0005167_abnormal_blood-brain_barrier1.35304312
31MP0000534_abnormal_ureter_morphology1.34409665
32MP0004484_altered_response_of1.33127586
33MP0009250_abnormal_appendicular_skeleto1.33000412
34MP0002896_abnormal_bone_mineralization1.31528567
35MP0009053_abnormal_anal_canal1.30810940
36MP0004858_abnormal_nervous_system1.29858793
37MP0001243_abnormal_dermal_layer1.23844070
38MP0003880_abnormal_central_pattern1.23579475
39MP0000767_abnormal_smooth_muscle1.21076073
40MP0003329_amyloid_beta_deposits1.20315839
41MP0005508_abnormal_skeleton_morphology1.20279755
42MP0003283_abnormal_digestive_organ1.17646602
43MP0010234_abnormal_vibrissa_follicle1.16577497
44* MP0005193_abnormal_anterior_eye1.16436169
45MP0005330_cardiomyopathy1.16218311
46MP0005620_abnormal_muscle_contractility1.12372508
47MP0010352_gastrointestinal_tract_polyps1.12149336
48MP0005409_darkened_coat_color1.10942704
49MP0003191_abnormal_cellular_cholesterol1.08651398
50MP0004036_abnormal_muscle_relaxation1.08031934
51MP0003942_abnormal_urinary_system1.07629025
52MP0003300_gastrointestinal_ulcer1.07563156
53MP0000733_abnormal_muscle_development1.06273955
54MP0005595_abnormal_vascular_smooth1.05920094
55MP0002972_abnormal_cardiac_muscle1.05853801
56MP0001849_ear_inflammation1.05670864
57MP0001915_intracranial_hemorrhage1.04938738
58MP0001348_abnormal_lacrimal_gland1.04523354
59MP0004087_abnormal_muscle_fiber1.04254400
60MP0002063_abnormal_learning/memory/cond1.03595864
61MP0000749_muscle_degeneration1.02833442
62MP0004130_abnormal_muscle_cell1.00222873
63MP0001177_atelectasis0.98520824
64MP0002060_abnormal_skin_morphology0.98448171
65MP0002234_abnormal_pharynx_morphology0.96615942
66MP0000759_abnormal_skeletal_muscle0.94561704
67MP0000428_abnormal_craniofacial_morphol0.93997035
68MP0002282_abnormal_trachea_morphology0.92680999
69MP0005023_abnormal_wound_healing0.92101237
70MP0002837_dystrophic_cardiac_calcinosis0.90597850
71MP0002133_abnormal_respiratory_system0.89929398
72MP0005388_respiratory_system_phenotype0.89929398
73MP0004085_abnormal_heartbeat0.89221026
74MP0006054_spinal_hemorrhage0.88934010
75MP0009745_abnormal_behavioral_response0.88382585
76MP0003828_pulmonary_edema0.88114484
77MP0008775_abnormal_heart_ventricle0.88051849
78MP0005257_abnormal_intraocular_pressure0.87679101
79MP0005385_cardiovascular_system_phenoty0.87435266
80MP0001544_abnormal_cardiovascular_syste0.87435266
81MP0005197_abnormal_uvea_morphology0.87341584
82MP0002168_other_aberrant_phenotype0.86905204
83MP0000003_abnormal_adipose_tissue0.86856441
84* MP0002128_abnormal_blood_circulation0.86600301
85MP0004215_abnormal_myocardial_fiber0.86180301
86MP0005164_abnormal_response_to0.85243803
87MP0001501_abnormal_sleep_pattern0.85170850
88MP0004270_analgesia0.84943045
89MP0010386_abnormal_urinary_bladder0.83854173
90MP0000163_abnormal_cartilage_morphology0.83392895
91MP0000778_abnormal_nervous_system0.82526966
92MP0003115_abnormal_respiratory_system0.81194876
93MP0003448_altered_tumor_morphology0.80732547
94MP0001614_abnormal_blood_vessel0.79088297
95MP0005165_increased_susceptibility_to0.78815519
96MP0003950_abnormal_plasma_membrane0.78256708
97MP0002925_abnormal_cardiovascular_devel0.77715175
98MP0000762_abnormal_tongue_morphology0.77534055
99MP0003755_abnormal_palate_morphology0.77008811
100MP0000747_muscle_weakness0.76978595
101MP0000467_abnormal_esophagus_morphology0.76364774
102MP0008961_abnormal_basal_metabolism0.75974007
103MP0000750_abnormal_muscle_regeneration0.75584876
104MP0002796_impaired_skin_barrier0.75420589
105MP0004134_abnormal_chest_morphology0.75339375
106MP0004885_abnormal_endolymph0.75254529
107MP0002877_abnormal_melanocyte_morpholog0.73609157
108MP0004233_abnormal_muscle_weight0.73352170
109MP0010630_abnormal_cardiac_muscle0.73261254
110MP0005390_skeleton_phenotype0.72569588
111MP0005084_abnormal_gallbladder_morpholo0.72513977
112MP0001346_abnormal_lacrimal_gland0.72055532
113MP0003935_abnormal_craniofacial_develop0.72012780
114MP0000516_abnormal_urinary_system0.71944019
115MP0001661_extended_life_span0.71396949
116MP0003868_abnormal_feces_composition0.70945818
117MP0002113_abnormal_skeleton_development0.69510784
118MP0000432_abnormal_head_morphology0.69267533
119MP0002933_joint_inflammation0.68778193
120MP0002115_abnormal_skeleton_extremities0.66695708
121MP0002932_abnormal_joint_morphology0.66132354
122MP0002092_abnormal_eye_morphology0.59772017
123MP0000462_abnormal_digestive_system0.59535955
124MP0000249_abnormal_blood_vessel0.58501547
125MP0005375_adipose_tissue_phenotype0.57970147
126MP0000538_abnormal_urinary_bladder0.56500586
127MP0005076_abnormal_cell_differentiation0.54909759
128MP0001175_abnormal_lung_morphology0.54731325
129MP0002177_abnormal_outer_ear0.54391303
130MP0005621_abnormal_cell_physiology0.54242161
131MP0002114_abnormal_axial_skeleton0.51950050
132MP0000266_abnormal_heart_morphology0.51719482
133MP0002332_abnormal_exercise_endurance0.51262247

Predicted human phenotypes

RankGene SetZ-score
1Nuclear cataract (HP:0100018)5.63417859
2Premature rupture of membranes (HP:0001788)4.87948266
3Zonular cataract (HP:0010920)4.47948614
4Protrusio acetabuli (HP:0003179)4.21069864
5Shallow orbits (HP:0000586)3.83881363
6Cerebral aneurysm (HP:0004944)3.60454468
7Aortic dissection (HP:0002647)3.54248066
8Atrophic scars (HP:0001075)3.40236257
9Aortic aneurysm (HP:0004942)3.27553135
10Follicular hyperkeratosis (HP:0007502)3.07748139
11Broad metatarsal (HP:0001783)3.05470268
12Vascular tortuosity (HP:0004948)2.98594018
13Spondylolisthesis (HP:0003302)2.97618023
14Osteolytic defects of the hand bones (HP:0009699)2.86299702
15Osteolytic defects of the phalanges of the hand (HP:0009771)2.86299702
16Vertebral compression fractures (HP:0002953)2.75856243
17Arterial tortuosity (HP:0005116)2.73381675
18Muscle fiber splitting (HP:0003555)2.72766394
19Right ventricular cardiomyopathy (HP:0011663)2.72519957
20Fragile skin (HP:0001030)2.64709687
21Increased connective tissue (HP:0009025)2.64231927
22Aortic regurgitation (HP:0001659)2.62952720
23Dilatation of the ascending aorta (HP:0005111)2.61769556
24Neonatal short-limb short stature (HP:0008921)2.59014573
25Buphthalmos (HP:0000557)2.58655790
26Mitral valve prolapse (HP:0001634)2.56469997
27Focal segmental glomerulosclerosis (HP:0000097)2.56077182
28Scapular winging (HP:0003691)2.54638003
29Cardiovascular calcification (HP:0011915)2.54496755
30Aplasia involving bones of the extremities (HP:0009825)2.53056936
31Aplasia involving bones of the upper limbs (HP:0009823)2.53056936
32Aplasia of the phalanges of the hand (HP:0009802)2.53056936
33Mitral regurgitation (HP:0001653)2.52094979
34Hyporeflexia of lower limbs (HP:0002600)2.51384338
35Bronchomalacia (HP:0002780)2.50236351
36Mitral stenosis (HP:0001718)2.49892274
37Ankle contracture (HP:0006466)2.49311501
38Abnormality of the acetabulum (HP:0003170)2.44276420
39Joint laxity (HP:0001388)2.44070234
40Amblyopia (HP:0000646)2.40178482
41Mildly elevated creatine phosphokinase (HP:0008180)2.40038236
42Aortic valve stenosis (HP:0001650)2.39505262
43Peritonitis (HP:0002586)2.38681758
44Hypoplasia of the iris (HP:0007676)2.26808847
45Spinal rigidity (HP:0003306)2.25736829
46Reduced subcutaneous adipose tissue (HP:0003758)2.25103630
47Bladder diverticulum (HP:0000015)2.21787147
48Increased variability in muscle fiber diameter (HP:0003557)2.20571426
49Aneurysm (HP:0002617)2.17401300
50Slender build (HP:0001533)2.16609203
51Biconcave vertebral bodies (HP:0004586)2.16014756
52Cervical subluxation (HP:0003308)2.15488845
53Wormian bones (HP:0002645)2.15483141
54Genu recurvatum (HP:0002816)2.15017631
55Overgrowth (HP:0001548)2.13403003
56Cerebral inclusion bodies (HP:0100314)2.13402904
57Abnormal delivery (HP:0001787)2.12319361
58Abnormality of dentin (HP:0010299)2.11899041
59Short hallux (HP:0010109)2.11581369
60Lower limb amyotrophy (HP:0007210)2.11084481
61Distal lower limb amyotrophy (HP:0008944)2.10990652
62Round ear (HP:0100830)2.10531578
63Disproportionate tall stature (HP:0001519)2.10305017
64Broad face (HP:0000283)2.09318841
65Mesangial abnormality (HP:0001966)2.08787232
66Corneal dystrophy (HP:0001131)2.08001446
67Natal tooth (HP:0000695)2.07643349
68Lymphangioma (HP:0100764)2.04292032
69Difficulty climbing stairs (HP:0003551)2.02449576
70Abnormality of carpal bone ossification (HP:0006257)2.00801824
71Soft skin (HP:0000977)1.99281690
72Abnormal ossification of hand bones (HP:0005921)1.99239563
73Coronal craniosynostosis (HP:0004440)1.98272593
74Abnormality of the nasal septum (HP:0000419)1.97780401
75Wrist flexion contracture (HP:0001239)1.95600555
76Coxa vara (HP:0002812)1.95392970
77Short nail (HP:0001799)1.94889307
78Entropion (HP:0000621)1.93977787
79Nonimmune hydrops fetalis (HP:0001790)1.93834982
80Glomerulosclerosis (HP:0000096)1.93317558
81Infantile muscular hypotonia (HP:0008947)1.92217430
82Joint stiffness (HP:0001387)1.92024899
83Long toe (HP:0010511)1.89762227
84Radial bowing (HP:0002986)1.89111508
85Spinal cord lesions (HP:0100561)1.87976600
86Syringomyelia (HP:0003396)1.87976600
87Aplasia/Hypoplasia of the hallux (HP:0008362)1.86975046
88Camptodactyly of toe (HP:0001836)1.86335452
89Difficulty running (HP:0009046)1.86011460
90Abnormality of skeletal muscle fiber size (HP:0012084)1.85890087
91Abnormality of the calf musculature (HP:0001430)1.85766995
92Distal lower limb muscle weakness (HP:0009053)1.85135788
93Hyperextensible skin (HP:0000974)1.84592372
94Rapidly progressive (HP:0003678)1.84157960
95Venous abnormality (HP:0002624)1.83000057
96Flexion contracture of toe (HP:0005830)1.79152512
97Joint contractures involving the joints of the feet (HP:0100492)1.79152512
98Blue sclerae (HP:0000592)1.78920159
99Venous insufficiency (HP:0005293)1.77465887
100Type 1 muscle fiber predominance (HP:0003803)1.76616293
101Ovoid vertebral bodies (HP:0003300)1.76512976
102Hip contracture (HP:0003273)1.76350489
103Absent frontal sinuses (HP:0002688)1.76030623
104Congenital glaucoma (HP:0001087)1.75821176
105Focal motor seizures (HP:0011153)1.73458016
106Increased density of long bones (HP:0006392)1.72415603
107Humeroradial synostosis (HP:0003041)1.71792753
108Synostosis involving the elbow (HP:0003938)1.71792753
109Knee flexion contracture (HP:0006380)1.71683138
110Hypoventilation (HP:0002791)1.71221420
111Vascular calcification (HP:0004934)1.70959936
112Protruding ear (HP:0000411)1.69906294
113Bradycardia (HP:0001662)1.69853655
114Bowed forearm bones (HP:0003956)1.69627041
115Bowing of the arm (HP:0006488)1.69627041
116Neurofibrillary tangles (HP:0002185)1.69474418
117Persistence of primary teeth (HP:0006335)1.69327380
118Renal duplication (HP:0000075)1.69081254
119Bowel diverticulosis (HP:0005222)1.67477781
120Upper limb amyotrophy (HP:0009129)1.67097207
121Distal upper limb amyotrophy (HP:0007149)1.67097207
122Abnormality of the anterior chamber (HP:0000593)1.66789788
123Focal seizures (HP:0007359)1.66103700
124Achilles tendon contracture (HP:0001771)1.66081247
125Abnormality of the middle phalanges of the toes (HP:0010183)1.66019996
126Glucose intolerance (HP:0000833)1.65995023
127Elbow flexion contracture (HP:0002987)1.65712367
128Inguinal hernia (HP:0000023)1.65405264
129Striae distensae (HP:0001065)1.65318813
130Broad ribs (HP:0000885)1.65094514
131Tibial bowing (HP:0002982)1.64175989
132Hemiplegia (HP:0002301)1.64079455
133Stage 5 chronic kidney disease (HP:0003774)1.63386600
134Congenital cataract (HP:0000519)1.63004293
135Wide anterior fontanel (HP:0000260)1.62552274
136Hydroureter (HP:0000072)1.62454418
137Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.61875957
138Anterior segment dysgenesis (HP:0007700)1.61648500
139Arachnodactyly (HP:0001166)1.60841552
140Deviation of the hallux (HP:0010051)1.60664823
141Limited hip movement (HP:0008800)1.60576719
142Mesomelia (HP:0003027)1.58907551
143Morphological abnormality of the middle ear (HP:0008609)1.58659870
144Ulnar bowing (HP:0003031)1.57924537
145Ectopia lentis (HP:0001083)1.57032931

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TTN4.00184397
2DDR22.66918747
3NEK92.62669329
4EPHB22.50254574
5DMPK2.38747678
6LATS22.16588655
7PAK32.13577385
8PDGFRA2.11604553
9LATS12.09517257
10RIPK12.04628283
11FER2.00266679
12TRIB31.99697248
13TIE11.92848732
14EPHA41.90911171
15PTK2B1.89860422
16TESK11.85583468
17NTRK31.83913273
18ERBB41.77554329
19AKT31.74478273
20MYLK1.71698693
21PAK21.63364324
22PTK21.54809716
23NTRK11.54351098
24WNK41.40867099
25FLT31.38564860
26TGFBR21.37775833
27ICK1.37432631
28ROCK11.26444589
29LMTK21.26226212
30PIK3CA1.24517681
31PAK61.23899945
32KDR1.23755855
33BMX1.23386438
34MARK11.22545907
35FGFR21.20560787
36MINK11.19517205
37MAP3K91.16015858
38STK381.10257734
39STK391.09522186
40PRKD31.08529319
41ROCK21.07735851
42PRKCH1.06965302
43PHKG21.05714579
44PHKG11.05714579
45PLK21.04640198
46MAP3K31.03530314
47TRPM71.03258439
48SIK21.02241561
49PDGFRB1.00712751
50SIK10.99848211
51TYRO30.98509768
52PIK3CG0.97497015
53EPHA20.97330572
54IRAK30.96892355
55MAP3K120.96431499
56PTK60.95657893
57PKN20.94939596
58FRK0.90956873
59RPS6KA20.89429889
60RET0.88465666
61LRRK20.88143992
62PRKD10.87807802
63ERN10.87480256
64NTRK20.87162254
65MAP3K60.86825519
66FGR0.84083086
67MARK20.83467944
68MAP2K10.82103734
69PRKCE0.81299605
70MAP3K20.80600715
71ABL20.78728620
72WNK10.78572973
73MELK0.78499744
74MET0.77426725
75MAP3K40.77132093
76CAMK2A0.76968184
77CDK80.76926356
78MAP3K70.76013978
79CAMK1G0.75985399
80CDK120.74896402
81STK110.74357270
82CDK50.74113729
83SGK10.74057738
84CDC42BPA0.73921234
85CAMK2B0.73825759
86OXSR10.73017508
87KSR20.72741122
88SCYL20.70694131
89GRK70.70589620
90TGFBR10.69871669
91SMG10.68856376
92INSR0.68663060
93DAPK30.68448907
94CAMKK10.68157821
95KSR10.66047867
96LIMK10.64000591
97FGFR10.62807833
98STK30.62442142
99PAK40.61392529
100STK38L0.60732216
101EEF2K0.59835412
102EPHB10.59037988
103MAPKAPK30.57368479
104MOS0.56343071
105PRKD20.54707101
106MST1R0.54289681
107SRC0.54146465
108ERBB30.53820587
109ILK0.53549126
110MAP2K30.51980755
111PRKG20.50277050
112MAPK120.49426061
113FGFR30.49274429
114MAP2K40.48969655
115CAMK2D0.48329244
116FYN0.47011104
117PDPK10.46326088
118SGK30.46046194
119SGK2230.45275370
120SGK4940.45275370
121CAMK2G0.44246551
122ADRBK10.42102454
123ARAF0.41098720
124IGF1R0.40325421
125GSK3A0.40308380
126CAMK1D0.40012537
127STK100.39772085
128GRK50.39752097
129MTOR0.39433596
130MST40.39349537
131FGFR40.36878929
132PIM20.35534752
133JAK10.34935240
134MAPK70.34818158
135PAK10.34289730
136CDK90.34053928
137MAP3K80.24293170
138MAPKAPK50.22592136
139MAPKAPK20.21344127
140CLK10.21263061

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045122.60237068
2Focal adhesion_Homo sapiens_hsa045102.06811757
3Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.01917800
4Dilated cardiomyopathy_Homo sapiens_hsa054142.01696463
5Glycosaminoglycan degradation_Homo sapiens_hsa005311.89125729
6Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.79042436
7Axon guidance_Homo sapiens_hsa043601.74697497
8Amoebiasis_Homo sapiens_hsa051461.62267946
9Gastric acid secretion_Homo sapiens_hsa049711.56743729
10Renin secretion_Homo sapiens_hsa049241.51534127
11Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.50613508
12Nicotine addiction_Homo sapiens_hsa050331.50172276
13Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.49661862
14Salivary secretion_Homo sapiens_hsa049701.48316547
15Adherens junction_Homo sapiens_hsa045201.46915803
16Proteoglycans in cancer_Homo sapiens_hsa052051.46433305
17AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.40549070
18Circadian entrainment_Homo sapiens_hsa047131.40388013
19Long-term potentiation_Homo sapiens_hsa047201.39282560
20Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.30717683
21Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.30650877
22Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.29759185
23Oxytocin signaling pathway_Homo sapiens_hsa049211.29489045
24Gap junction_Homo sapiens_hsa045401.25337897
25Regulation of actin cytoskeleton_Homo sapiens_hsa048101.23877520
26Glutamatergic synapse_Homo sapiens_hsa047241.23810145
27Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.23521705
28Aldosterone synthesis and secretion_Homo sapiens_hsa049251.22808776
29Melanogenesis_Homo sapiens_hsa049161.22425940
30Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.21143962
31Vascular smooth muscle contraction_Homo sapiens_hsa042701.19651705
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.19639841
33Rap1 signaling pathway_Homo sapiens_hsa040151.18895607
34GABAergic synapse_Homo sapiens_hsa047271.18022367
35Protein digestion and absorption_Homo sapiens_hsa049741.17035889
36Hippo signaling pathway_Homo sapiens_hsa043901.15797086
37Glioma_Homo sapiens_hsa052141.14274416
38Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.13478450
39GnRH signaling pathway_Homo sapiens_hsa049121.13003629
40Small cell lung cancer_Homo sapiens_hsa052221.12855471
41cGMP-PKG signaling pathway_Homo sapiens_hsa040221.12009191
42Tight junction_Homo sapiens_hsa045301.11748654
43Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.09876399
44Dorso-ventral axis formation_Homo sapiens_hsa043201.09297126
45Central carbon metabolism in cancer_Homo sapiens_hsa052301.09183981
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.07651546
47Morphine addiction_Homo sapiens_hsa050321.07487728
48Estrogen signaling pathway_Homo sapiens_hsa049151.07365349
49Amphetamine addiction_Homo sapiens_hsa050311.06508372
50cAMP signaling pathway_Homo sapiens_hsa040241.06195647
51Calcium signaling pathway_Homo sapiens_hsa040201.03115839
52Cholinergic synapse_Homo sapiens_hsa047251.02923248
53Long-term depression_Homo sapiens_hsa047300.99851038
54Prion diseases_Homo sapiens_hsa050200.99710136
55Shigellosis_Homo sapiens_hsa051310.99673692
56Leukocyte transendothelial migration_Homo sapiens_hsa046700.98748646
57Renal cell carcinoma_Homo sapiens_hsa052110.98460412
58TGF-beta signaling pathway_Homo sapiens_hsa043500.94772052
59Dopaminergic synapse_Homo sapiens_hsa047280.93423642
60Platelet activation_Homo sapiens_hsa046110.92583441
61Bladder cancer_Homo sapiens_hsa052190.92325180
62Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90928394
63Taste transduction_Homo sapiens_hsa047420.90314049
64Olfactory transduction_Homo sapiens_hsa047400.90213734
65Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.89919987
66Phospholipase D signaling pathway_Homo sapiens_hsa040720.89198223
67Cocaine addiction_Homo sapiens_hsa050300.88240616
68Insulin secretion_Homo sapiens_hsa049110.88189831
69Complement and coagulation cascades_Homo sapiens_hsa046100.87547103
70Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87529605
71N-Glycan biosynthesis_Homo sapiens_hsa005100.85829810
72Basal cell carcinoma_Homo sapiens_hsa052170.83662547
73ErbB signaling pathway_Homo sapiens_hsa040120.83507583
74Serotonergic synapse_Homo sapiens_hsa047260.82825660
75PI3K-Akt signaling pathway_Homo sapiens_hsa041510.82538933
76Ras signaling pathway_Homo sapiens_hsa040140.81679429
77Nitrogen metabolism_Homo sapiens_hsa009100.80972553
78Vibrio cholerae infection_Homo sapiens_hsa051100.80848970
79VEGF signaling pathway_Homo sapiens_hsa043700.80751786
80p53 signaling pathway_Homo sapiens_hsa041150.80431648
81Wnt signaling pathway_Homo sapiens_hsa043100.78816980
82Prostate cancer_Homo sapiens_hsa052150.78511158
83Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.76250927
84Thyroid hormone synthesis_Homo sapiens_hsa049180.75074281
85MAPK signaling pathway_Homo sapiens_hsa040100.75008744
86Sulfur metabolism_Homo sapiens_hsa009200.74146183
87Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.73853781
88Thyroid cancer_Homo sapiens_hsa052160.73497696
89Choline metabolism in cancer_Homo sapiens_hsa052310.72955380
90Synaptic vesicle cycle_Homo sapiens_hsa047210.72182477
91Hedgehog signaling pathway_Homo sapiens_hsa043400.71737361
92Melanoma_Homo sapiens_hsa052180.71020299
93Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.70124985
94Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.70103957
95Bile secretion_Homo sapiens_hsa049760.68527515
96Ovarian steroidogenesis_Homo sapiens_hsa049130.68378063
97MicroRNAs in cancer_Homo sapiens_hsa052060.66974967
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.65924522
99Viral myocarditis_Homo sapiens_hsa054160.65061119
100Other glycan degradation_Homo sapiens_hsa005110.64613635
101Pathways in cancer_Homo sapiens_hsa052000.63859358
102Thyroid hormone signaling pathway_Homo sapiens_hsa049190.63402120
103Sphingolipid metabolism_Homo sapiens_hsa006000.60913090
104Salmonella infection_Homo sapiens_hsa051320.60765763
105Endocytosis_Homo sapiens_hsa041440.59837029
106Malaria_Homo sapiens_hsa051440.59045159
107Galactose metabolism_Homo sapiens_hsa000520.58348525
108Chronic myeloid leukemia_Homo sapiens_hsa052200.57759797
109TNF signaling pathway_Homo sapiens_hsa046680.57537280
110Endometrial cancer_Homo sapiens_hsa052130.56729371
111Pancreatic cancer_Homo sapiens_hsa052120.55446389
112Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.54940471
113Cardiac muscle contraction_Homo sapiens_hsa042600.54570217
114Sphingolipid signaling pathway_Homo sapiens_hsa040710.54100785
115Pancreatic secretion_Homo sapiens_hsa049720.51902990
116Type II diabetes mellitus_Homo sapiens_hsa049300.50127448
117Mineral absorption_Homo sapiens_hsa049780.50094456
118Toxoplasmosis_Homo sapiens_hsa051450.49995424
119Inositol phosphate metabolism_Homo sapiens_hsa005620.49183928
120Neurotrophin signaling pathway_Homo sapiens_hsa047220.49095245
121Notch signaling pathway_Homo sapiens_hsa043300.48311270
122Pertussis_Homo sapiens_hsa051330.45448555
123AMPK signaling pathway_Homo sapiens_hsa041520.44100788
124Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.41456459
125Colorectal cancer_Homo sapiens_hsa052100.40824855
126HIF-1 signaling pathway_Homo sapiens_hsa040660.39791720
127Pentose phosphate pathway_Homo sapiens_hsa000300.36358969
128Insulin signaling pathway_Homo sapiens_hsa049100.36350342
129FoxO signaling pathway_Homo sapiens_hsa040680.36298965
130Insulin resistance_Homo sapiens_hsa049310.36070566
131Glucagon signaling pathway_Homo sapiens_hsa049220.36010354
132Renin-angiotensin system_Homo sapiens_hsa046140.35735332
133mTOR signaling pathway_Homo sapiens_hsa041500.34771305
134Lysosome_Homo sapiens_hsa041420.33594770

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