CRIP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a putative transcription factor with two LIM zinc-binding domains. The encoded protein may participate in the differentiation of smooth muscle tissue. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cardiac myofibril assembly (GO:0055003)7.76864678
2sarcomere organization (GO:0045214)7.59967121
3muscle filament sliding (GO:0030049)6.68213949
4actin-myosin filament sliding (GO:0033275)6.68213949
5myofibril assembly (GO:0030239)6.60696452
6negative regulation of potassium ion transmembrane transporter activity (GO:1901017)6.03089768
7cardiac muscle contraction (GO:0060048)6.00755345
8cardiac muscle tissue morphogenesis (GO:0055008)5.96251066
9cardiac muscle cell development (GO:0055013)5.87078030
10bundle of His cell to Purkinje myocyte communication (GO:0086069)5.85885252
11ventricular cardiac muscle tissue morphogenesis (GO:0055010)5.84391311
12actin-mediated cell contraction (GO:0070252)5.70054365
13negative regulation of potassium ion transmembrane transport (GO:1901380)5.57182359
14cardiac cell development (GO:0055006)5.56579670
15mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.52335960
16negative regulation of cardiac muscle cell apoptotic process (GO:0010667)5.39407222
17muscle tissue morphogenesis (GO:0060415)5.35415108
18tricarboxylic acid cycle (GO:0006099)5.31526975
19ventricular cardiac muscle cell action potential (GO:0086005)5.28606102
20heart trabecula formation (GO:0060347)5.23230831
21actomyosin structure organization (GO:0031032)5.20264764
22heart process (GO:0003015)5.14857382
23heart contraction (GO:0060047)5.14857382
24ATP synthesis coupled proton transport (GO:0015986)5.13354577
25energy coupled proton transport, down electrochemical gradient (GO:0015985)5.13354577
26regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO5.06836527
27cardiac muscle hypertrophy (GO:0003300)5.06447549
28negative regulation of striated muscle cell apoptotic process (GO:0010664)5.04779498
29regulation of cardioblast differentiation (GO:0051890)5.04094524
30positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)4.96038278
31regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)4.86455949
32regulation of relaxation of muscle (GO:1901077)4.83757782
33striated muscle hypertrophy (GO:0014897)4.77748323
34plasma membrane repair (GO:0001778)4.74930901
35adult heart development (GO:0007512)4.72567599
36regulation of actin filament-based movement (GO:1903115)4.72202333
37regulation of the force of heart contraction (GO:0002026)4.48774421
38ventricular cardiac muscle cell development (GO:0055015)4.45195463
39regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)4.45178036
40striated muscle contraction (GO:0006941)4.42492776
41regulation of sarcomere organization (GO:0060297)4.41089293
42regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)4.39257588
43oxidative phosphorylation (GO:0006119)4.35794848
44regulation of skeletal muscle contraction (GO:0014819)4.31271202
45actin filament-based movement (GO:0030048)4.17636528
46cell communication involved in cardiac conduction (GO:0086065)4.16683249
47regulation of striated muscle cell apoptotic process (GO:0010662)4.12676405
48mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.09826124
49respiratory electron transport chain (GO:0022904)4.09787430
50muscle hypertrophy (GO:0014896)4.09578485
51regulation of striated muscle contraction (GO:0006942)4.09496530
52electron transport chain (GO:0022900)4.02514447
53negative regulation of protein localization to cell surface (GO:2000009)3.89779730
54regulation of membrane repolarization (GO:0060306)3.89547225
55cardiac muscle cell action potential involved in contraction (GO:0086002)3.84935778
56desmosome organization (GO:0002934)3.80996820
57regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)3.76729283
58cardiac muscle cell action potential (GO:0086001)3.76039632
59regulation of heart rate (GO:0002027)3.74976184
60cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.73571917
61regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.71915132
62regulation of cardiac muscle cell apoptotic process (GO:0010665)3.64341669
63cardiac muscle hypertrophy in response to stress (GO:0014898)3.56012844
64muscle hypertrophy in response to stress (GO:0003299)3.56012844
65cardiac muscle adaptation (GO:0014887)3.56012844
66outflow tract septum morphogenesis (GO:0003148)3.54263563
67regulation of ATPase activity (GO:0043462)3.51639982
68regulation of ATP catabolic process (GO:1903289)3.51639982
69regulation of cell communication by electrical coupling (GO:0010649)3.47326023
70regulation of acyl-CoA biosynthetic process (GO:0050812)3.45891204
71cell communication by electrical coupling (GO:0010644)3.44320208
72NADH metabolic process (GO:0006734)3.42537869
73regulation of heart rate by cardiac conduction (GO:0086091)3.41444883
74striated muscle cell development (GO:0055002)3.38862331
75trabecula formation (GO:0060343)3.38506775
76regulation of heart contraction (GO:0008016)3.33001238
77cardiac right ventricle morphogenesis (GO:0003215)3.33000595
78regulation of cardiac muscle contraction (GO:0055117)3.29473516
79ATP biosynthetic process (GO:0006754)3.28892637
80regulation of cofactor metabolic process (GO:0051193)3.25016157
81regulation of coenzyme metabolic process (GO:0051196)3.25016157
82cardiac conduction (GO:0061337)3.24690194
83cardiac chamber formation (GO:0003207)3.18698162
84carnitine shuttle (GO:0006853)3.14291100
85negative regulation of potassium ion transport (GO:0043267)3.12377541
86dendritic spine morphogenesis (GO:0060997)3.10093554
87atrioventricular valve morphogenesis (GO:0003181)3.09551774
88regulation of muscle contraction (GO:0006937)3.08462614
89negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)3.05544491
90regulation of cardiac muscle cell contraction (GO:0086004)3.04534788
91response to stimulus involved in regulation of muscle adaptation (GO:0014874)3.04333240
92neuronal ion channel clustering (GO:0045161)3.03206528
93detection of calcium ion (GO:0005513)3.01301197
94membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.00555041
95regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.98387035
96muscle cell development (GO:0055001)2.94555207
97synaptic vesicle docking involved in exocytosis (GO:0016081)2.94052666
98cardiac muscle tissue development (GO:0048738)2.93073055
99muscle contraction (GO:0006936)2.89772137
100potassium ion export (GO:0071435)2.87142466
101atrial septum morphogenesis (GO:0060413)2.85554338
102heart trabecula morphogenesis (GO:0061384)2.83984933
103ventricular trabecula myocardium morphogenesis (GO:0003222)2.82441008
104sarcoplasmic reticulum calcium ion transport (GO:0070296)2.81530843
105purine nucleoside triphosphate biosynthetic process (GO:0009145)2.81432392
106dendritic spine organization (GO:0097061)2.79532436
107semaphorin-plexin signaling pathway (GO:0071526)2.78011340
108cell junction maintenance (GO:0034331)2.73743743
109regulation of synapse structural plasticity (GO:0051823)2.73609134
110glutamate secretion (GO:0014047)2.68965604
111synaptic vesicle exocytosis (GO:0016079)2.57872401
112cardiac ventricle formation (GO:0003211)2.57736360
113endothelial cell chemotaxis (GO:0035767)2.52778369
114regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act2.52272307
115cell migration in hindbrain (GO:0021535)2.51552581
116vocalization behavior (GO:0071625)2.51395758
117vascular endothelial growth factor signaling pathway (GO:0038084)2.49707918
118cell-cell junction maintenance (GO:0045217)2.49470792
119adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.48995038
120neurological system process involved in regulation of systemic arterial blood pressure (GO:0001976)2.47334081
121activation of protein kinase A activity (GO:0034199)2.45620909
122cAMP biosynthetic process (GO:0006171)2.44246090
123regulation of synapse maturation (GO:0090128)2.41921694
124axonal fasciculation (GO:0007413)2.41414090
125positive regulation of action potential (GO:0045760)2.38979142
126negative regulation of catenin import into nucleus (GO:0035414)2.37654954
127calcium-mediated signaling using intracellular calcium source (GO:0035584)2.35221605
128regulation of axon extension involved in axon guidance (GO:0048841)2.35020252
129neuron recognition (GO:0008038)2.34094542
130auditory behavior (GO:0031223)2.32149944
131cellular response to catecholamine stimulus (GO:0071870)2.31877219
132cellular response to monoamine stimulus (GO:0071868)2.31877219
133sodium ion export (GO:0071436)2.31863079
134synaptic vesicle maturation (GO:0016188)2.30121363
135metanephric nephron epithelium development (GO:0072243)2.29920342
136positive regulation of synapse maturation (GO:0090129)2.28478906
137regulation of axon guidance (GO:1902667)2.28086827
138cellular response to vascular endothelial growth factor stimulus (GO:0035924)2.26427638
139positive regulation of sodium ion transport (GO:0010765)2.26377853
140positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.24042535
141negative regulation of phosphatidylinositol 3-kinase signaling (GO:0014067)2.23432040
142regulation of short-term neuronal synaptic plasticity (GO:0048172)2.22796983
143axon extension (GO:0048675)2.22288959
144heart valve morphogenesis (GO:0003179)2.22162669
145axon extension involved in axon guidance (GO:0048846)2.19957169
146neuron projection extension involved in neuron projection guidance (GO:1902284)2.19957169
147cytoskeletal anchoring at plasma membrane (GO:0007016)2.19376056
148dopamine receptor signaling pathway (GO:0007212)2.18017058
149epithelial cell-cell adhesion (GO:0090136)2.16914415
150regulation of voltage-gated calcium channel activity (GO:1901385)2.16855952
151response to monoamine (GO:0071867)2.16557898

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.87845641
2* EP300_21415370_ChIP-Seq_HL-1_Mouse4.13445050
3* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.82469182
4TRIM28_21343339_ChIP-Seq_HEK293_Human3.71096727
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.68020615
6RARG_19884340_ChIP-ChIP_MEFs_Mouse3.59413282
7ZNF263_19887448_ChIP-Seq_K562_Human2.99947671
8TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse2.95121053
9MEF2A_21415370_ChIP-Seq_HL-1_Mouse2.71636940
10TBX20_22328084_ChIP-Seq_HEART_Mouse2.59289367
11TBX20_22080862_ChIP-Seq_HEART_Mouse2.59289367
12ESR1_20079471_ChIP-ChIP_T-47D_Human2.57742934
13TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.46999395
14NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.41980387
15CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human2.37429030
16TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.14663999
17DROSHA_22980978_ChIP-Seq_HELA_Human2.11380653
18SUZ12_27294783_Chip-Seq_ESCs_Mouse2.10046577
19ESR2_21235772_ChIP-Seq_MCF-7_Human2.01458847
20SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.00661566
21RNF2_27304074_Chip-Seq_ESCs_Mouse1.95726418
22* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.95196196
23CLOCK_20551151_ChIP-Seq_293T_Human1.93753167
24EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88338317
25* GATA4_21415370_ChIP-Seq_HL-1_Mouse1.82302966
26NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.79674586
27LXR_22292898_ChIP-Seq_THP-1_Human1.78569471
28JARID2_20064375_ChIP-Seq_MESCs_Mouse1.75685388
29MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.74201868
30* PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.71653956
31CDX2_19796622_ChIP-Seq_MESCs_Mouse1.70798007
32HIF1A_21447827_ChIP-Seq_MCF-7_Human1.70292264
33NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.62679369
34DNAJC2_21179169_ChIP-ChIP_NT2_Human1.58073738
35RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.52884803
36* KDM2B_26808549_Chip-Seq_K562_Human1.51951666
37* RARB_27405468_Chip-Seq_BRAIN_Mouse1.45717888
38CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.44519773
39CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.44426694
40* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.43374201
41SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.43196822
42RBPJ_22232070_ChIP-Seq_NCS_Mouse1.42558834
43SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.42077755
44SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41391816
45ESR1_21235772_ChIP-Seq_MCF-7_Human1.39846603
46* TET1_21490601_ChIP-Seq_MESCs_Mouse1.38444208
47WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.35915981
48* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.34998101
49* RING1B_27294783_Chip-Seq_ESCs_Mouse1.33951422
50OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.32535555
51ISL1_27105846_Chip-Seq_CPCs_Mouse1.31730399
52TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.30699577
53SMC4_20622854_ChIP-Seq_HELA_Human1.29719912
54ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.28539508
55EED_16625203_ChIP-ChIP_MESCs_Mouse1.28395133
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.28160749
57NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.26178745
58CJUN_26792858_Chip-Seq_BT549_Human1.25782380
59PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.25178845
60* REST_21632747_ChIP-Seq_MESCs_Mouse1.24970321
61SRF_21415370_ChIP-Seq_HL-1_Mouse1.24255315
62RNF2_18974828_ChIP-Seq_MESCs_Mouse1.24080397
63EZH2_18974828_ChIP-Seq_MESCs_Mouse1.24080397
64WT1_19549856_ChIP-ChIP_CCG9911_Human1.22439666
65TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22415754
66TP53_20018659_ChIP-ChIP_R1E_Mouse1.18603421
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.18452795
68* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.17991385
69SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.17350939
70TET1_21451524_ChIP-Seq_MESCs_Mouse1.17191071
71SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.16648203
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.16306293
73KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.15476562
74* REST_18959480_ChIP-ChIP_MESCs_Mouse1.15126433
75* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15035317
76CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12056141
77CTCF_27219007_Chip-Seq_Bcells_Human1.09959017
78RING1B_27294783_Chip-Seq_NPCs_Mouse1.09713289
79ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09463302
80SALL4_18804426_ChIP-ChIP_XEN_Mouse1.09015901
81* SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.08842629
82IKZF1_21737484_ChIP-ChIP_HCT116_Human1.07447961
83EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.07435371
84* TP53_23651856_ChIP-Seq_MEFs_Mouse1.06930753
85NFIB_24661679_ChIP-Seq_LUNG_Mouse1.06427176
86RAD21_21589869_ChIP-Seq_MESCs_Mouse1.05887257
87P68_20966046_ChIP-Seq_HELA_Human1.05699174
88* RUNX1_27514584_Chip-Seq_MCF-7_Human1.04702478
89* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.04642031
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.04020291
91ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03039477
92ATF3_27146783_Chip-Seq_COLON_Human1.02063216
93CREB1_26743006_Chip-Seq_LNCaP_Human1.01852845
94ZFP281_27345836_Chip-Seq_ESCs_Mouse1.01017346
95PPAR_26484153_Chip-Seq_NCI-H1993_Human1.00477854
96SOX9_24532713_ChIP-Seq_HFSC_Mouse0.99616797
97EZH2_27294783_Chip-Seq_ESCs_Mouse0.98467103
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.98388305
99SMC3_22415368_ChIP-Seq_MEFs_Mouse0.98024100
100JARID2_20075857_ChIP-Seq_MESCs_Mouse0.97327647
101MTF2_20144788_ChIP-Seq_MESCs_Mouse0.96748086
102HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.96673354
103RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.96485519
104PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.95616237
105* ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95252498
106TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.95182567
107SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.95059996
108STAT6_21828071_ChIP-Seq_BEAS2B_Human0.94779095
109ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.94553550
110* RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.93596483
111FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.93528030
112ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93153649
113ELK1_22589737_ChIP-Seq_MCF10A_Human0.92687413
114KDM2B_26808549_Chip-Seq_DND41_Human0.92501901
115* UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.91947662
116SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91008181
117AHR_22903824_ChIP-Seq_MCF-7_Human0.90956022
118NR3C1_23031785_ChIP-Seq_PC12_Mouse0.90590772
119* RACK7_27058665_Chip-Seq_MCF-7_Human0.90279489
120* TP63_22573176_ChIP-Seq_HFKS_Human0.90093466
121RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.89905383
122SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.89460169
123POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.87771984
124TBX5_21415370_ChIP-Seq_HL-1_Mouse0.86386405
125* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.85251278
126KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.85026400
127* ELK3_25401928_ChIP-Seq_HUVEC_Human0.84565965
128BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.84480660
129NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.83465680
130SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.83109289
131SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.83109289
132TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.83057369
133STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80832667
134* CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.79770256
135ZNF274_21170338_ChIP-Seq_K562_Hela0.79488413
136FOXH1_21741376_ChIP-Seq_ESCs_Human0.78937115
137GATA2_21666600_ChIP-Seq_HMVEC_Human0.78705211
138EZH2_22144423_ChIP-Seq_EOC_Human0.78619200
139SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.78473358
140* TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.77911652
141JARID1A_20064375_ChIP-Seq_MESCs_Mouse0.77854496
142MYC_19829295_ChIP-Seq_ESCs_Human0.77395426
143CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.77065122
144CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.75855452
145P63_26484246_Chip-Seq_KERATINOCYTES_Human0.74735957
146ERG_21242973_ChIP-ChIP_JURKAT_Human0.74380830
147JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.74065029
148YY1_22570637_ChIP-Seq_MALME-3M_Human0.72870116

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004084_abnormal_cardiac_muscle5.99802361
2MP0002837_dystrophic_cardiac_calcinosis5.17384227
3MP0000751_myopathy4.14887341
4MP0004215_abnormal_myocardial_fiber4.10415039
5MP0004036_abnormal_muscle_relaxation4.09520796
6MP0000749_muscle_degeneration4.06710392
7MP0003646_muscle_fatigue3.71421343
8MP0005330_cardiomyopathy3.64478542
9MP0002972_abnormal_cardiac_muscle3.33272039
10MP0008775_abnormal_heart_ventricle3.01882392
11MP0006138_congestive_heart_failure2.76418816
12MP0004087_abnormal_muscle_fiber2.64646613
13MP0005620_abnormal_muscle_contractility2.64236036
14MP0003137_abnormal_impulse_conducting2.63314371
15MP0001544_abnormal_cardiovascular_syste2.61107815
16MP0005385_cardiovascular_system_phenoty2.61107815
17MP0004859_abnormal_synaptic_plasticity2.57264509
18MP0009780_abnormal_chondrocyte_physiolo2.54200745
19MP0003828_pulmonary_edema2.40343429
20MP0010630_abnormal_cardiac_muscle2.37933260
21MP0000750_abnormal_muscle_regeneration2.37905458
22MP0004085_abnormal_heartbeat2.32417601
23MP0004484_altered_response_of2.23800520
24MP0002127_abnormal_cardiovascular_syste2.05946816
25MP0003950_abnormal_plasma_membrane1.98560530
26MP0003221_abnormal_cardiomyocyte_apopto1.98180276
27MP0002106_abnormal_muscle_physiology1.95330926
28MP0002269_muscular_atrophy1.93339596
29MP0010368_abnormal_lymphatic_system1.85899312
30MP0004272_abnormal_basement_membrane1.78288059
31MP0003880_abnormal_central_pattern1.75407381
32MP0003279_aneurysm1.67120397
33MP0005423_abnormal_somatic_nervous1.64080652
34MP0005369_muscle_phenotype1.60941825
35MP0004145_abnormal_muscle_electrophysio1.59728572
36MP0000759_abnormal_skeletal_muscle1.56314191
37MP0000747_muscle_weakness1.50089338
38MP0003567_abnormal_fetal_cardiomyocyte1.49746707
39MP0001879_abnormal_lymphatic_vessel1.48995867
40MP0004233_abnormal_muscle_weight1.48563452
41MP0003635_abnormal_synaptic_transmissio1.48062583
42MP0002332_abnormal_exercise_endurance1.46459060
43MP0005409_darkened_coat_color1.42235157
44MP0002653_abnormal_ependyma_morphology1.40096183
45MP0006036_abnormal_mitochondrial_physio1.33197152
46MP0001502_abnormal_circadian_rhythm1.32319010
47MP0004130_abnormal_muscle_cell1.28180147
48MP0002063_abnormal_learning/memory/cond1.27872404
49MP0004510_myositis1.26450986
50MP0002572_abnormal_emotion/affect_behav1.25238541
51MP0000778_abnormal_nervous_system1.25105398
52MP0002249_abnormal_larynx_morphology1.23773971
53MP0003941_abnormal_skin_development1.17820118
54MP0009745_abnormal_behavioral_response1.17405826
55MP0003566_abnormal_cell_adhesion1.16810599
56MP0003329_amyloid_beta_deposits1.15498439
57MP0002909_abnormal_adrenal_gland1.15486905
58MP0005275_abnormal_skin_tensile1.14991300
59MP0000003_abnormal_adipose_tissue1.14184857
60MP0002234_abnormal_pharynx_morphology1.12389635
61MP0002735_abnormal_chemical_nociception1.10711974
62MP0003705_abnormal_hypodermis_morpholog1.10571935
63MP0000266_abnormal_heart_morphology1.09395542
64MP0005165_increased_susceptibility_to1.09377426
65MP0002064_seizures1.09087094
66MP0005623_abnormal_meninges_morphology1.07509655
67MP0002272_abnormal_nervous_system1.06373285
68MP0000566_synostosis1.05642280
69MP0003806_abnormal_nucleotide_metabolis1.03135531
70MP0001486_abnormal_startle_reflex0.99682670
71MP0003879_abnormal_hair_cell0.99133417
72MP0001299_abnormal_eye_distance/0.99030274
73MP0000767_abnormal_smooth_muscle0.94527011
74MP0000343_altered_response_to0.94366286
75MP0000230_abnormal_systemic_arterial0.94237917
76MP0001984_abnormal_olfaction0.92898378
77MP0004858_abnormal_nervous_system0.92238064
78MP0006035_abnormal_mitochondrial_morpho0.92163300
79MP0005451_abnormal_body_composition0.91729838
80MP0001970_abnormal_pain_threshold0.91195559
81MP0010030_abnormal_orbit_morphology0.91166103
82MP0002184_abnormal_innervation0.88922196
83MP0008569_lethality_at_weaning0.86016883
84MP0003122_maternal_imprinting0.83421946
85MP0000462_abnormal_digestive_system0.83370131
86MP0003123_paternal_imprinting0.81400095
87MP0005595_abnormal_vascular_smooth0.81133591
88MP0002128_abnormal_blood_circulation0.81018196
89MP0002882_abnormal_neuron_morphology0.80702642
90MP0002557_abnormal_social/conspecific_i0.80277897
91MP0008438_abnormal_cutaneous_collagen0.78926130
92MP0005377_hearing/vestibular/ear_phenot0.78922589
93MP0003878_abnormal_ear_physiology0.78922589
94MP0009384_cardiac_valve_regurgitation0.78919044
95MP0004133_heterotaxia0.78605405
96MP0001968_abnormal_touch/_nociception0.78533651
97MP0000049_abnormal_middle_ear0.77466749
98MP0002736_abnormal_nociception_after0.76982337
99MP0002638_abnormal_pupillary_reflex0.76012858
100MP0005375_adipose_tissue_phenotype0.75483308
101MP0003634_abnormal_glial_cell0.74952602
102MP0000762_abnormal_tongue_morphology0.74395178
103MP0005508_abnormal_skeleton_morphology0.74162013
104MP0006276_abnormal_autonomic_nervous0.73591181
105MP0001905_abnormal_dopamine_level0.73262157
106MP0005670_abnormal_white_adipose0.72793657
107MP0001958_emphysema0.72430171
108MP0002733_abnormal_thermal_nociception0.72236255
109MP0000026_abnormal_inner_ear0.71146705
110MP0003283_abnormal_digestive_organ0.70505111
111MP0003942_abnormal_urinary_system0.69947589
112MP0000537_abnormal_urethra_morphology0.69477079
113MP0000013_abnormal_adipose_tissue0.69163650
114MP0000955_abnormal_spinal_cord0.67906761
115MP0002295_abnormal_pulmonary_circulatio0.66334589
116MP0005503_abnormal_tendon_morphology0.63838270
117MP0001542_abnormal_bone_strength0.62107631
118MP0002925_abnormal_cardiovascular_devel0.61974459
119MP0002108_abnormal_muscle_morphology0.61304373
120MP0005266_abnormal_metabolism0.57245561
121MP0002088_abnormal_embryonic_growth/wei0.55388248
122MP0003984_embryonic_growth_retardation0.55089969
123MP0002796_impaired_skin_barrier0.53563006
124MP0000534_abnormal_ureter_morphology0.52154986
125MP0002133_abnormal_respiratory_system0.50163093
126MP0005388_respiratory_system_phenotype0.50163093
127MP0001784_abnormal_fluid_regulation0.50005236
128MP0005187_abnormal_penis_morphology0.49692853
129MP0001614_abnormal_blood_vessel0.48057272
130MP0005167_abnormal_blood-brain_barrier0.45791702
131MP0005666_abnormal_adipose_tissue0.45672738
132MP0003385_abnormal_body_wall0.42841103
133MP0001756_abnormal_urination0.39662629
134MP0009379_abnormal_foot_pigmentation0.39381367
135MP0002751_abnormal_autonomic_nervous0.38704436
136MP0002734_abnormal_mechanical_nocicepti0.37657393
137MP0002822_catalepsy0.37652922
138MP0002282_abnormal_trachea_morphology0.36202079
139MP0009697_abnormal_copulation0.36007844
140MP0004270_analgesia0.35302074
141MP0005380_embryogenesis_phenotype0.35090102
142MP0001672_abnormal_embryogenesis/_devel0.35090102

Predicted human phenotypes

RankGene SetZ-score
1Sudden death (HP:0001699)7.44619948
2Ventricular tachycardia (HP:0004756)6.47790713
3Atrial fibrillation (HP:0005110)5.67213265
4Primary atrial arrhythmia (HP:0001692)5.34014022
5Calf muscle hypertrophy (HP:0008981)5.32798647
6Supraventricular tachycardia (HP:0004755)5.18850121
7Supraventricular arrhythmia (HP:0005115)5.11426259
8Right ventricular cardiomyopathy (HP:0011663)5.10823483
9Lipoatrophy (HP:0100578)5.04423402
10Exercise-induced muscle cramps (HP:0003710)4.86880827
11Abnormality of the calf musculature (HP:0001430)4.72551103
12Muscle hypertrophy of the lower extremities (HP:0008968)4.68604402
13Muscle fiber splitting (HP:0003555)4.67633563
14Hyporeflexia of lower limbs (HP:0002600)4.65394346
15Exercise-induced myalgia (HP:0003738)4.46115309
16Syncope (HP:0001279)4.41704358
17Palpitations (HP:0001962)4.30378330
18Abnormality of the left ventricular outflow tract (HP:0011103)4.16158800
19Subaortic stenosis (HP:0001682)4.16158800
20Prolonged QT interval (HP:0001657)3.93439942
21Ventricular arrhythmia (HP:0004308)3.92646243
22Dilated cardiomyopathy (HP:0001644)3.91982162
23EMG: myopathic abnormalities (HP:0003458)3.77243263
24Ventricular fibrillation (HP:0001663)3.65517616
25Acute necrotizing encephalopathy (HP:0006965)3.61383979
26Distal lower limb muscle weakness (HP:0009053)3.58510465
27Bundle branch block (HP:0011710)3.58226712
28Myokymia (HP:0002411)3.55372893
29Myoglobinuria (HP:0002913)3.49521316
30Abnormal mitochondria in muscle tissue (HP:0008316)3.42986737
31Increased connective tissue (HP:0009025)3.35056776
32Lymphangioma (HP:0100764)3.29238498
33Myotonia (HP:0002486)3.19749968
34Atrioventricular block (HP:0001678)3.14091803
35Heart block (HP:0012722)3.10337996
36Abnormal atrioventricular conduction (HP:0005150)3.10163047
37Hepatic necrosis (HP:0002605)3.01668182
38Asymmetric septal hypertrophy (HP:0001670)3.01021254
39Abnormal EKG (HP:0003115)2.99152547
40Progressive macrocephaly (HP:0004481)2.95859850
41Double outlet right ventricle (HP:0001719)2.95804759
42Congenital malformation of the right heart (HP:0011723)2.95804759
43Rhabdomyolysis (HP:0003201)2.92727778
44Mitochondrial inheritance (HP:0001427)2.89052346
45Acute encephalopathy (HP:0006846)2.88467727
46Left ventricular hypertrophy (HP:0001712)2.84799607
47Palmoplantar keratoderma (HP:0000982)2.82483810
48Areflexia of lower limbs (HP:0002522)2.76113729
49Hepatocellular necrosis (HP:0001404)2.75438587
50Upper limb amyotrophy (HP:0009129)2.72810912
51Distal upper limb amyotrophy (HP:0007149)2.72810912
52Increased CSF lactate (HP:0002490)2.70007162
53Difficulty climbing stairs (HP:0003551)2.69635777
54Conjunctival hamartoma (HP:0100780)2.68200435
55Pheochromocytoma (HP:0002666)2.58900573
56Increased serum pyruvate (HP:0003542)2.56298448
57Abnormality of glycolysis (HP:0004366)2.56298448
58Abnormality of the foot musculature (HP:0001436)2.55576471
59Exercise intolerance (HP:0003546)2.55411928
60Ragged-red muscle fibers (HP:0003200)2.54597337
61Cerebral aneurysm (HP:0004944)2.48915475
62Patent foramen ovale (HP:0001655)2.46089347
63Hypoplastic left heart (HP:0004383)2.45191449
64Distal lower limb amyotrophy (HP:0008944)2.40584144
65Foot dorsiflexor weakness (HP:0009027)2.38851106
66Neoplasm of the adrenal gland (HP:0100631)2.38189071
67Wrist flexion contracture (HP:0001239)2.36197075
68Neuroendocrine neoplasm (HP:0100634)2.35000443
69Obstructive sleep apnea (HP:0002870)2.34998059
70Respiratory failure (HP:0002878)2.34257052
71Neck muscle weakness (HP:0000467)2.33580515
72Diaphragmatic weakness (HP:0009113)2.29851212
73Cerebral edema (HP:0002181)2.29394534
74Hand muscle atrophy (HP:0009130)2.28044534
75Difficulty running (HP:0009046)2.15852009
76Lactic acidosis (HP:0003128)2.15362263
77Hypoplastic heart (HP:0001961)2.12451946
78Muscle stiffness (HP:0003552)2.07971915
79Bradycardia (HP:0001662)2.06062477
80Ulnar claw (HP:0001178)2.05844229
81Protrusio acetabuli (HP:0003179)2.05513624
82Type 1 muscle fiber predominance (HP:0003803)2.05291871
83Premature rupture of membranes (HP:0001788)2.00776771
84J-shaped sella turcica (HP:0002680)2.00753558
85Rimmed vacuoles (HP:0003805)2.00232896
86Limb-girdle muscle atrophy (HP:0003797)1.99212403
87Testicular atrophy (HP:0000029)1.98858660
88Pulmonary artery stenosis (HP:0004415)1.96541907
89EMG: neuropathic changes (HP:0003445)1.94682701
90Nuclear cataract (HP:0100018)1.94363892
91Infantile muscular hypotonia (HP:0008947)1.93351111
92Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.92661920
93Lower limb amyotrophy (HP:0007210)1.92228145
94Atelectasis (HP:0100750)1.90730918
95Steppage gait (HP:0003376)1.89778221
96Generalized muscle weakness (HP:0003324)1.89158804
97Mildly elevated creatine phosphokinase (HP:0008180)1.88842800
98Round ear (HP:0100830)1.87716894
99Congestive heart failure (HP:0001635)1.87652116
100Sudden cardiac death (HP:0001645)1.84562385
101Centrally nucleated skeletal muscle fibers (HP:0003687)1.83092872
102Neoplasm of the heart (HP:0100544)1.81741657
103Spinal rigidity (HP:0003306)1.81567669
104Abnormality of dicarboxylic acid metabolism (HP:0010995)1.81241299
105Dicarboxylic aciduria (HP:0003215)1.81241299
106Increased variability in muscle fiber diameter (HP:0003557)1.80773288
107Sleep apnea (HP:0010535)1.80598171
108Growth hormone excess (HP:0000845)1.79691038
109Increased muscle lipid content (HP:0009058)1.78585685
110Ankle clonus (HP:0011448)1.77666906
111Hypercortisolism (HP:0001578)1.76645130
112Muscular dystrophy (HP:0003560)1.76301935
113Shallow orbits (HP:0000586)1.75725536
114Stridor (HP:0010307)1.75699185
115Bell-shaped thorax (HP:0001591)1.74794984
116Hypoventilation (HP:0002791)1.74387284
117Polyphagia (HP:0002591)1.74174746
118Occipital encephalocele (HP:0002085)1.73379875
119Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.71201243
120Abnormality of the vocal cords (HP:0008777)1.70426906
121Akinesia (HP:0002304)1.70360999
122Increased serum lactate (HP:0002151)1.70243002
123Bronchomalacia (HP:0002780)1.70162483
124Mesangial abnormality (HP:0001966)1.69781925
125Athetosis (HP:0002305)1.69600200
126Decreased activity of mitochondrial respiratory chain (HP:0008972)1.68783735
127Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.68783735
128Broad metatarsal (HP:0001783)1.68061918
129Cavernous hemangioma (HP:0001048)1.67499329
130Increased intramyocellular lipid droplets (HP:0012240)1.67090488
131Aplasia of the musculature (HP:0100854)1.65666248
132Hamartoma of the eye (HP:0010568)1.65639320
133Scapular winging (HP:0003691)1.64865850
134Limb dystonia (HP:0002451)1.63388731
135Cerebral hemorrhage (HP:0001342)1.63298990
136Lipid accumulation in hepatocytes (HP:0006561)1.62581928
137Vascular tortuosity (HP:0004948)1.62426854
138Abnormal respiratory epithelium morphology (HP:0012253)1.61740821
139Abnormal respiratory motile cilium morphology (HP:0005938)1.61740821
140Joint stiffness (HP:0001387)1.61403016
141Visceral angiomatosis (HP:0100761)1.61181584
142Bulbar palsy (HP:0001283)1.60520952
143Hyperacusis (HP:0010780)1.59106963
144Abnormal ciliary motility (HP:0012262)1.57232093
145Arterial tortuosity (HP:0005116)1.55086819
146Abnormality of the aortic arch (HP:0012303)1.54346171
147Mitral regurgitation (HP:0001653)1.53864705
148Abnormal respiratory motile cilium physiology (HP:0012261)1.51403759
149Torticollis (HP:0000473)1.50683076
150Long toe (HP:0010511)1.50480562
151Gowers sign (HP:0003391)1.50452483
152Bladder diverticulum (HP:0000015)1.49958965
153Abnormality of the nasal mucosa (HP:0000433)1.49663234
154Hip contracture (HP:0003273)1.47807487
155Abnormality of dentin (HP:0010299)1.47410773

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK5.04812987
2OBSCN4.53965974
3LMTK23.38619999
4TTN3.26844976
5TIE13.18169128
6STK243.01159067
7PHKG22.61776146
8PHKG12.61776146
9PDK32.50358583
10PDK42.50358583
11SIK12.46815027
12MAPK152.44644057
13STK38L2.38870826
14ZAK2.31668038
15LIMK12.16625750
16NEK12.13916829
17RIPK11.91562766
18DMPK1.85070178
19PIK3CA1.78542516
20EPHA41.75267707
21TESK11.71878954
22PDK21.71372404
23PKN21.71313808
24ILK1.68704688
25TRIB31.61991376
26NTRK31.58904251
27KDR1.57876900
28EPHB11.56374208
29EPHB21.53703785
30MAPKAPK31.52960334
31BCKDK1.49248677
32PAK31.46835929
33PTK21.45644683
34PAK61.44069115
35EPHA21.42675165
36MAP3K31.41055935
37FER1.35843174
38MUSK1.32420495
39DAPK31.30630167
40LATS21.30550190
41PINK11.27991175
42ROCK11.24817869
43UHMK11.24384578
44CDC42BPA1.24208153
45PTK2B1.17938169
46NTRK21.16840381
47CASK1.16792507
48MARK21.15995088
49GRK71.11770236
50EPHA31.07728402
51MAP3K61.07390927
52CAMK2B1.06115296
53MET1.05635606
54MST1R1.03533921
55TRPM71.01084676
56BUB11.00092337
57DAPK21.00032383
58AKT30.99895322
59CAMK2D0.98237948
60BCR0.95362263
61PRKD30.93045008
62PRKD10.89601519
63ARAF0.83920707
64PRKD20.81740563
65SIK30.80060312
66ROCK20.78808294
67NME10.78702542
68MAP3K50.76090473
69MAP2K10.75982810
70DDR20.75779983
71PRKCE0.75272449
72MAPK130.74660064
73MAPK120.72195716
74MAP3K110.71952529
75CAMKK10.71505991
76CDK50.71156460
77DYRK20.68575158
78GRK50.68507294
79PTK60.68308360
80MINK10.68002969
81PIM20.67309932
82PKN10.66347359
83MARK10.66224543
84MAP2K70.65486999
85TGFBR20.63806014
86MAP3K70.63724985
87DYRK1B0.63188824
88NTRK10.62270871
89CAMK2A0.62178316
90ICK0.61779810
91PLK20.60044810
92ERBB20.59679028
93WNK40.57604953
94RPS6KL10.54189521
95RPS6KC10.54189521
96PLK40.52697540
97TGFBR10.47024951
98SIK20.46964166
99MAPK40.44076845
100MARK30.43307570
101RET0.43144684
102LRRK20.42338925
103CAMK10.41459267
104CAMK2G0.41343430
105MAP2K30.41269554
106RPS6KA20.41032819
107TAOK10.41003681
108MTOR0.40468129
109ERBB30.40439787
110RPS6KA60.40082009
111PRKCG0.38745979
112ADRBK10.38483061
113FGFR40.37907886
114PRKACA0.37810793
115MAP3K120.37275234
116MAP2K20.36960583
117NME20.36768815
118TSSK60.36273347
119TAOK20.34546960
120NEK90.34365133
121PRKG20.33776072
122CDK140.33290393
123PRKAA10.33139482
124PDGFRA0.32593840
125CAMK40.32531570
126BRSK10.31012174
127BRSK20.30926967
128BRAF0.30040135
129SGK2230.29645302
130SGK4940.29645302
131AURKA0.29480089
132PRKCI0.25876758
133SGK20.25157660
134STK380.25139887
135FGFR10.23604180
136AKT20.22709392
137MAPKAPK20.21760733
138PAK40.21622237
139PRKACG0.20152580

Predicted pathways (KEGG)

RankGene SetZ-score
1Citrate cycle (TCA cycle)_Homo sapiens_hsa000205.36467413
2Cardiac muscle contraction_Homo sapiens_hsa042604.83267656
3Oxidative phosphorylation_Homo sapiens_hsa001904.20482647
4Parkinsons disease_Homo sapiens_hsa050124.13399436
5Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054103.57686602
62-Oxocarboxylic acid metabolism_Homo sapiens_hsa012103.55941523
7Dilated cardiomyopathy_Homo sapiens_hsa054143.49241503
8Huntingtons disease_Homo sapiens_hsa050162.95496187
9Alzheimers disease_Homo sapiens_hsa050102.89687351
10Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.41180585
11Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054122.30033933
12Proteasome_Homo sapiens_hsa030502.16128941
13Carbon metabolism_Homo sapiens_hsa012002.15171610
14Propanoate metabolism_Homo sapiens_hsa006402.12146041
15Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.81608960
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.81164118
17Cocaine addiction_Homo sapiens_hsa050301.70481631
18Fatty acid degradation_Homo sapiens_hsa000711.65357286
19Pyruvate metabolism_Homo sapiens_hsa006201.55992770
20GABAergic synapse_Homo sapiens_hsa047271.50990459
21Amphetamine addiction_Homo sapiens_hsa050311.50206426
22Nicotine addiction_Homo sapiens_hsa050331.43762235
23Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.42882697
24Morphine addiction_Homo sapiens_hsa050321.42813829
25Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.42376656
26Dopaminergic synapse_Homo sapiens_hsa047281.39688243
27Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.37876669
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37103370
29Glutamatergic synapse_Homo sapiens_hsa047241.34734989
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.34296312
31Aldosterone synthesis and secretion_Homo sapiens_hsa049251.33683945
32Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.31192899
33Tight junction_Homo sapiens_hsa045301.30149181
34Fatty acid metabolism_Homo sapiens_hsa012121.28139984
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.25069052
36Notch signaling pathway_Homo sapiens_hsa043301.19169468
37Viral myocarditis_Homo sapiens_hsa054161.16951169
38Salivary secretion_Homo sapiens_hsa049701.12564731
39Fatty acid elongation_Homo sapiens_hsa000621.08044730
40Cholinergic synapse_Homo sapiens_hsa047251.06211542
41Biosynthesis of amino acids_Homo sapiens_hsa012301.03637355
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.01959300
43Glycosaminoglycan degradation_Homo sapiens_hsa005311.01070924
44Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.93531609
45Phenylalanine metabolism_Homo sapiens_hsa003600.92573904
46Estrogen signaling pathway_Homo sapiens_hsa049150.91191803
47cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90290913
48Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.89681683
49Circadian rhythm_Homo sapiens_hsa047100.89591764
50HIF-1 signaling pathway_Homo sapiens_hsa040660.88914375
51Focal adhesion_Homo sapiens_hsa045100.88742059
52Ovarian steroidogenesis_Homo sapiens_hsa049130.83288076
53Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.83084175
54Bile secretion_Homo sapiens_hsa049760.81595411
55Fructose and mannose metabolism_Homo sapiens_hsa000510.80968876
56ECM-receptor interaction_Homo sapiens_hsa045120.79758857
57Sulfur relay system_Homo sapiens_hsa041220.77543889
58Long-term potentiation_Homo sapiens_hsa047200.77263097
59Serotonergic synapse_Homo sapiens_hsa047260.74347577
60Phospholipase D signaling pathway_Homo sapiens_hsa040720.73669248
61Vascular smooth muscle contraction_Homo sapiens_hsa042700.73559480
62Adherens junction_Homo sapiens_hsa045200.73312412
63Hippo signaling pathway_Homo sapiens_hsa043900.72433773
64VEGF signaling pathway_Homo sapiens_hsa043700.70124741
65Galactose metabolism_Homo sapiens_hsa000520.70089921
66Glucagon signaling pathway_Homo sapiens_hsa049220.69277665
67Arginine biosynthesis_Homo sapiens_hsa002200.68047902
68Cyanoamino acid metabolism_Homo sapiens_hsa004600.66134789
69Histidine metabolism_Homo sapiens_hsa003400.65007059
70Butanoate metabolism_Homo sapiens_hsa006500.64868286
71Thyroid hormone synthesis_Homo sapiens_hsa049180.63599110
72Tyrosine metabolism_Homo sapiens_hsa003500.63594664
73Prion diseases_Homo sapiens_hsa050200.63308134
74Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.63165299
75Calcium signaling pathway_Homo sapiens_hsa040200.63116762
76Insulin signaling pathway_Homo sapiens_hsa049100.62080521
77Central carbon metabolism in cancer_Homo sapiens_hsa052300.60697873
78Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58079740
79Pancreatic secretion_Homo sapiens_hsa049720.56798957
80RNA polymerase_Homo sapiens_hsa030200.55445569
81Oxytocin signaling pathway_Homo sapiens_hsa049210.55351801
82Ras signaling pathway_Homo sapiens_hsa040140.54549555
83Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.54151858
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.53746662
85Endocytosis_Homo sapiens_hsa041440.53701921
86Long-term depression_Homo sapiens_hsa047300.53168139
87Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.51610802
88ErbB signaling pathway_Homo sapiens_hsa040120.49293582
89Glioma_Homo sapiens_hsa052140.48386921
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.48385868
91PPAR signaling pathway_Homo sapiens_hsa033200.47351889
92Arginine and proline metabolism_Homo sapiens_hsa003300.46200505
93Glutathione metabolism_Homo sapiens_hsa004800.45697555
94Gap junction_Homo sapiens_hsa045400.45414472
95Protein digestion and absorption_Homo sapiens_hsa049740.45165831
96Melanogenesis_Homo sapiens_hsa049160.43055679
97Hedgehog signaling pathway_Homo sapiens_hsa043400.42951598
98Phototransduction_Homo sapiens_hsa047440.42101992
99Basal cell carcinoma_Homo sapiens_hsa052170.41926057
100Metabolic pathways_Homo sapiens_hsa011000.41790486
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.41261408
102Endometrial cancer_Homo sapiens_hsa052130.40424508
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.39883872
104Starch and sucrose metabolism_Homo sapiens_hsa005000.39692114
105Collecting duct acid secretion_Homo sapiens_hsa049660.39525171
106Insulin resistance_Homo sapiens_hsa049310.39142147
107Regulation of autophagy_Homo sapiens_hsa041400.38363505
108Ribosome_Homo sapiens_hsa030100.37039160
109Proteoglycans in cancer_Homo sapiens_hsa052050.36962837
110Thyroid hormone signaling pathway_Homo sapiens_hsa049190.35136805
111Taste transduction_Homo sapiens_hsa047420.34431551
112Renin secretion_Homo sapiens_hsa049240.33564803
113AMPK signaling pathway_Homo sapiens_hsa041520.30805288
114Adipocytokine signaling pathway_Homo sapiens_hsa049200.29945033
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.29731225
116Olfactory transduction_Homo sapiens_hsa047400.29251545
117Regulation of actin cytoskeleton_Homo sapiens_hsa048100.29088002
118Purine metabolism_Homo sapiens_hsa002300.29036674
119Circadian entrainment_Homo sapiens_hsa047130.28978601
120Axon guidance_Homo sapiens_hsa043600.27627093
121Gastric acid secretion_Homo sapiens_hsa049710.27479688
122Vibrio cholerae infection_Homo sapiens_hsa051100.27431113
123Rap1 signaling pathway_Homo sapiens_hsa040150.26201236
124Insulin secretion_Homo sapiens_hsa049110.24873958
125Oocyte meiosis_Homo sapiens_hsa041140.24700073
126Amoebiasis_Homo sapiens_hsa051460.24629923
127PI3K-Akt signaling pathway_Homo sapiens_hsa041510.24063495
128Tryptophan metabolism_Homo sapiens_hsa003800.22342306
129cAMP signaling pathway_Homo sapiens_hsa040240.21778205
130Cysteine and methionine metabolism_Homo sapiens_hsa002700.19886710
131Thyroid cancer_Homo sapiens_hsa052160.18184630
132TGF-beta signaling pathway_Homo sapiens_hsa043500.17773267
133Melanoma_Homo sapiens_hsa052180.17580800
134beta-Alanine metabolism_Homo sapiens_hsa004100.16644159
135Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.16348015
136AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.15618506
137Synaptic vesicle cycle_Homo sapiens_hsa047210.15023748
138Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.14900182
139Renal cell carcinoma_Homo sapiens_hsa052110.14821650
140Peroxisome_Homo sapiens_hsa041460.14647613
141Pathways in cancer_Homo sapiens_hsa052000.14627948
142GnRH signaling pathway_Homo sapiens_hsa049120.13955429
143Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.13815179
144Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.12872781

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