CRIP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of dendritic cell antigen processing and presentation (GO:0002604)8.26391244
2antigen processing and presentation of endogenous antigen (GO:0019883)8.01480249
3oxygen transport (GO:0015671)7.48016508
4positive regulation of Cdc42 GTPase activity (GO:0043089)6.67549458
5NIK/NF-kappaB signaling (GO:0038061)6.50726929
6positive regulation of granulocyte chemotaxis (GO:0071624)6.43622554
7neurotransmitter catabolic process (GO:0042135)6.21780020
8positive regulation of antigen processing and presentation (GO:0002579)5.93770514
9bundle of His cell to Purkinje myocyte communication (GO:0086069)5.72470339
10virion attachment to host cell (GO:0019062)5.54036562
11adhesion of symbiont to host cell (GO:0044650)5.54036562
12chaperone-mediated protein transport (GO:0072321)5.48366797
13substrate-independent telencephalic tangential interneuron migration (GO:0021843)5.25721682
14substrate-independent telencephalic tangential migration (GO:0021826)5.25721682
15imidazole-containing compound metabolic process (GO:0052803)5.21246400
16positive regulation of natural killer cell differentiation (GO:0032825)5.12363626
17tongue development (GO:0043586)5.11824355
18regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)5.03266256
19cellular response to ATP (GO:0071318)5.01835018
20regulation of antigen processing and presentation (GO:0002577)4.99780591
21mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.96842874
22pericardium development (GO:0060039)4.94922203
23proline transport (GO:0015824)4.89910154
24regulation of mitochondrial translation (GO:0070129)4.85130682
25establishment of protein localization to mitochondrial membrane (GO:0090151)4.76677708
26positive regulation of monocyte chemotaxis (GO:0090026)4.74699753
27regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)4.73280261
28regulation of mitotic spindle checkpoint (GO:1903504)4.73280261
29growth hormone secretion (GO:0030252)4.70398219
30regulation of Cdc42 GTPase activity (GO:0043088)4.68817104
31positive regulation of growth hormone secretion (GO:0060124)4.67852123
32positive regulation of insulin-like growth factor receptor signaling pathway (GO:0043568)4.64080051
33chromatin remodeling at centromere (GO:0031055)4.55398948
34regulation of T-helper 1 cell differentiation (GO:0045625)4.48808807
35regulation of cellular extravasation (GO:0002691)4.43248668
36CENP-A containing nucleosome assembly (GO:0034080)4.33395424
37purine nucleobase biosynthetic process (GO:0009113)4.31600705
38pharyngeal system development (GO:0060037)4.26394344
39adhesion of symbiont to host (GO:0044406)4.25644716
40ATP synthesis coupled proton transport (GO:0015986)4.24853027
41energy coupled proton transport, down electrochemical gradient (GO:0015985)4.24853027
42IMP biosynthetic process (GO:0006188)4.14171814
43L-serine metabolic process (GO:0006563)4.11263665
44nitric oxide biosynthetic process (GO:0006809)4.09276264
45gas transport (GO:0015669)4.08164920
46determination of adult lifespan (GO:0008340)4.04278010
47establishment of integrated proviral latency (GO:0075713)4.04110935
48DNA replication checkpoint (GO:0000076)4.03150081
49hemidesmosome assembly (GO:0031581)4.02513158
50positive regulation of neutrophil chemotaxis (GO:0090023)4.02269365
51positive regulation of neutrophil migration (GO:1902624)4.02269365
52positive regulation of receptor biosynthetic process (GO:0010870)4.02067902
53negative regulation of mitotic metaphase/anaphase transition (GO:0045841)4.01256143
54negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)4.01256143
55negative regulation of mitotic sister chromatid segregation (GO:0033048)4.01256143
56negative regulation of mitotic sister chromatid separation (GO:2000816)4.01256143
57negative regulation of sister chromatid segregation (GO:0033046)4.01256143
58negative regulation of interleukin-10 production (GO:0032693)4.01046030
59histone exchange (GO:0043486)3.99216859
60regulation of nuclear cell cycle DNA replication (GO:0033262)3.98620834
61termination of RNA polymerase III transcription (GO:0006386)3.92409480
62transcription elongation from RNA polymerase III promoter (GO:0006385)3.92409480
63negative regulation of chromosome segregation (GO:0051985)3.92113938
64spliceosomal snRNP assembly (GO:0000387)3.88732069
65regulation of natural killer cell differentiation (GO:0032823)3.88026776
66negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class 3.87830465
67negative regulation of DNA-dependent DNA replication (GO:2000104)3.82976320
68nucleobase biosynthetic process (GO:0046112)3.79838466
69respiratory electron transport chain (GO:0022904)3.72753265
70IMP metabolic process (GO:0046040)3.71804151
71regulation of posttranscriptional gene silencing (GO:0060147)3.71029106
72regulation of gene silencing by miRNA (GO:0060964)3.71029106
73regulation of gene silencing by RNA (GO:0060966)3.71029106
74positive regulation of T-helper 1 type immune response (GO:0002827)3.69400826
75proteasome assembly (GO:0043248)3.68955257
76regulation of granulocyte chemotaxis (GO:0071622)3.67844834
77DNA replication-independent nucleosome organization (GO:0034724)3.66089449
78DNA replication-independent nucleosome assembly (GO:0006336)3.66089449
79mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.65811833
80positive regulation of T-helper cell differentiation (GO:0045624)3.64860089
81respiratory chain complex IV assembly (GO:0008535)3.64790032
82ventricular cardiac muscle cell development (GO:0055015)3.62040250
83diaphragm development (GO:0060539)3.61295237
84electron transport chain (GO:0022900)3.60268568
85exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.59193515
86serine family amino acid biosynthetic process (GO:0009070)3.57084061
87positive regulation of macrophage cytokine production (GO:0060907)3.56893621
88regulation of lipoprotein particle clearance (GO:0010984)3.56572325
89negative regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043518)3.54284067
90asymmetric protein localization (GO:0008105)3.53696538
91mitochondrial respiratory chain complex assembly (GO:0033108)3.53285321
92dendritic cell differentiation (GO:0097028)3.53070638
93protein complex biogenesis (GO:0070271)3.52442892
94cytochrome complex assembly (GO:0017004)3.51022563
95nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.47612669
96membrane tubulation (GO:0097320)3.47458981
97synapsis (GO:0007129)3.45563041
98activation of Rac GTPase activity (GO:0032863)3.44147984
99mitotic spindle assembly checkpoint (GO:0007094)3.42338942
100regulation of transforming growth factor beta2 production (GO:0032909)3.41841909
101regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.40838963
102regulation of mitotic metaphase/anaphase transition (GO:0030071)3.40838963
103negative regulation of telomerase activity (GO:0051974)3.40144574
104glycine metabolic process (GO:0006544)3.39312817
105transcription from mitochondrial promoter (GO:0006390)3.38192843
106urea cycle (GO:0000050)3.37072795
107urea metabolic process (GO:0019627)3.37072795
108antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.36907569
109antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.36907569
110spindle assembly checkpoint (GO:0071173)3.36839271
111mitotic spindle checkpoint (GO:0071174)3.35000087
112regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator 3.33747724
113regulation of monocyte chemotaxis (GO:0090025)3.33457315
114alkaloid metabolic process (GO:0009820)3.33264174
115spindle checkpoint (GO:0031577)3.33054131
116germinal center formation (GO:0002467)3.32140000
117regulation of mitotic sister chromatid segregation (GO:0033047)3.30325363
118regulation of sister chromatid segregation (GO:0033045)3.30325363
119regulation of mitotic sister chromatid separation (GO:0010965)3.30325363
120negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.29351830
121regulation of MHC class II biosynthetic process (GO:0045346)3.27124846
122histone mRNA metabolic process (GO:0008334)3.26715086
123skeletal muscle organ development (GO:0060538)3.25939214
124mitochondrial respiratory chain complex I assembly (GO:0032981)3.25587094
125NADH dehydrogenase complex assembly (GO:0010257)3.25587094
126mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.25587094
127hypothalamus development (GO:0021854)3.25311014
128myeloid dendritic cell differentiation (GO:0043011)3.24962045
129detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)3.24944188
130negative regulation of mitosis (GO:0045839)3.23643169
131DNA strand elongation involved in DNA replication (GO:0006271)3.23461945
132arginine metabolic process (GO:0006525)3.23409622
133embryonic heart tube development (GO:0035050)3.21053606
134regulation of helicase activity (GO:0051095)3.20796059
135water-soluble vitamin biosynthetic process (GO:0042364)3.20032833
136protein neddylation (GO:0045116)3.17214298
137protein targeting to mitochondrion (GO:0006626)3.16839676
138heterochromatin organization (GO:0070828)3.15821894
139serine family amino acid metabolic process (GO:0009069)3.09522539
140axonal fasciculation (GO:0007413)3.06954688
141DNA strand elongation (GO:0022616)3.05421062
142regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.04944040
143serine family amino acid catabolic process (GO:0009071)3.03126814
144regulation of bile acid biosynthetic process (GO:0070857)3.02929952
145oxidative phosphorylation (GO:0006119)3.00837362
146DNA damage response, detection of DNA damage (GO:0042769)3.00582595
147positive regulation of transcription initiation from RNA polymerase II promoter (GO:0060261)2.98428682
148nitrogen cycle metabolic process (GO:0071941)2.97612183
149regulation of growth hormone secretion (GO:0060123)2.96252719
150establishment of viral latency (GO:0019043)2.93678279
151desmosome organization (GO:0002934)2.93561735
152kinetochore organization (GO:0051383)2.92547857
153positive regulation of cholesterol efflux (GO:0010875)2.92292820
154telomere maintenance via semi-conservative replication (GO:0032201)2.91931637
155cellular response to vitamin (GO:0071295)2.90999497
156termination of RNA polymerase II transcription (GO:0006369)2.90577275
157establishment of protein localization to mitochondrion (GO:0072655)2.89857922
158negative regulation of ligase activity (GO:0051352)2.89369935
159negative regulation of ubiquitin-protein transferase activity (GO:0051444)2.89369935
160regulation of chromosome segregation (GO:0051983)2.85684542
161mitotic metaphase plate congression (GO:0007080)2.84880143
162chaperone mediated protein folding requiring cofactor (GO:0051085)2.84472322
163negative thymic T cell selection (GO:0045060)2.83933338
164synaptic transmission, cholinergic (GO:0007271)2.83339007
165positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.83083729
166prostanoid biosynthetic process (GO:0046457)2.82540243
167prostaglandin biosynthetic process (GO:0001516)2.82540243
168regulation of memory T cell differentiation (GO:0043380)2.82239073
169negative regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902254)2.81995403
170L-fucose catabolic process (GO:0042355)2.81801712
171fucose catabolic process (GO:0019317)2.81801712
172L-fucose metabolic process (GO:0042354)2.81801712
173protein localization to kinetochore (GO:0034501)2.81019090
174rRNA modification (GO:0000154)2.80212389
175DNA ligation (GO:0006266)2.79307906
176protein localization to mitochondrion (GO:0070585)2.78750661
177positive regulation of leukocyte chemotaxis (GO:0002690)2.78500044
178somatic diversification of immune receptors via somatic mutation (GO:0002566)2.77443635
179somatic hypermutation of immunoglobulin genes (GO:0016446)2.77443635
180DNA replication-dependent nucleosome organization (GO:0034723)2.77363313
181DNA replication-dependent nucleosome assembly (GO:0006335)2.77363313
182pseudouridine synthesis (GO:0001522)2.76623329
183inner mitochondrial membrane organization (GO:0007007)2.76448822
184dendritic cell chemotaxis (GO:0002407)2.75543397
185negative regulation of proteasomal ubiquitin-dependent protein catabolic process (GO:0032435)2.74495005
186negative regulation of nuclear division (GO:0051784)2.74392786
187pre-miRNA processing (GO:0031054)2.74376179
188DNA-templated transcription, termination (GO:0006353)2.73731507
189histone H4-K12 acetylation (GO:0043983)2.71541859
190regulation of activation of Janus kinase activity (GO:0010533)2.70731697
191regulation of macrophage cytokine production (GO:0010935)2.69579814
192positive regulation of leukocyte mediated cytotoxicity (GO:0001912)2.69383938
193regulation of neutrophil chemotaxis (GO:0090022)2.69163513
194regulation of neutrophil migration (GO:1902622)2.69163513
195positive regulation of glycoprotein biosynthetic process (GO:0010560)2.66947868
196positive regulation of filopodium assembly (GO:0051491)2.64622865
197head development (GO:0060322)2.63004372
198regulation of leukocyte mediated cytotoxicity (GO:0001910)2.62675635
199positive regulation of cholesterol transport (GO:0032376)2.61090200
200positive regulation of sterol transport (GO:0032373)2.61090200

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.01707357
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse5.62815601
3KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.37122951
4TP63_17297297_ChIP-ChIP_HaCaT_Human4.17036988
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.41627830
6MYCN_21190229_ChIP-Seq_SHEP-21N_Human3.32705559
7E2F4_17652178_ChIP-ChIP_JURKAT_Human3.30200296
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.24330682
9HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.17919898
10GABP_17652178_ChIP-ChIP_JURKAT_Human2.97222787
11CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.78372006
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.77216769
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.59080241
14DROSHA_22980978_ChIP-Seq_HELA_Human2.53836186
15JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.49601781
16MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45604203
17JARID2_20075857_ChIP-Seq_MESCs_Mouse2.44746179
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.34509568
19MYC_19079543_ChIP-ChIP_MESCs_Mouse2.27502174
20FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.26030814
21SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.25342431
22MYC_18358816_ChIP-ChIP_MESCs_Mouse2.23499808
23THAP11_20581084_ChIP-Seq_MESCs_Mouse2.21738527
24FOXP3_21729870_ChIP-Seq_TREG_Human2.15363817
25EZH2_22144423_ChIP-Seq_EOC_Human2.14974131
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.13431081
27JARID2_20064375_ChIP-Seq_MESCs_Mouse2.11927594
28SUZ12_27294783_Chip-Seq_ESCs_Mouse2.08212330
29RNF2_18974828_ChIP-Seq_MESCs_Mouse2.05233338
30EZH2_18974828_ChIP-Seq_MESCs_Mouse2.05233338
31EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.02563239
32CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.02454677
33SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.01729106
34FOXM1_23109430_ChIP-Seq_U2OS_Human1.97427686
35SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.96983424
36SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.92618507
37ERG_21242973_ChIP-ChIP_JURKAT_Human1.92378844
38MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90083852
39CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.89934480
40IKZF1_21737484_ChIP-ChIP_HCT116_Human1.88919851
41VDR_23849224_ChIP-Seq_CD4+_Human1.86914620
42PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.86802846
43POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.85927487
44EZH2_27304074_Chip-Seq_ESCs_Mouse1.84953229
45SALL1_21062744_ChIP-ChIP_HESCs_Human1.82629858
46SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.82400032
47YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.80932048
48RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.80747906
49MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.79028138
50MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.76549368
51RNF2_27304074_Chip-Seq_ESCs_Mouse1.69324030
52SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.69206959
53TRIM28_21343339_ChIP-Seq_HEK293_Human1.69108621
54MYC_18940864_ChIP-ChIP_HL60_Human1.66907248
55E2F1_18555785_ChIP-Seq_MESCs_Mouse1.65765281
56ESR2_21235772_ChIP-Seq_MCF-7_Human1.65738042
57ELK1_19687146_ChIP-ChIP_HELA_Human1.64210164
58KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.63446404
59KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.63446404
60KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.63446404
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.62720062
62YY1_21170310_ChIP-Seq_MESCs_Mouse1.60769694
63SMAD_19615063_ChIP-ChIP_OVARY_Human1.59492770
64TTF2_22483619_ChIP-Seq_HELA_Human1.59464181
65SOX2_16153702_ChIP-ChIP_HESCs_Human1.58950088
66GBX2_23144817_ChIP-Seq_PC3_Human1.58216511
67FOXO3_23340844_ChIP-Seq_DLD1_Human1.58156481
68NELFA_20434984_ChIP-Seq_ESCs_Mouse1.55935449
69XRN2_22483619_ChIP-Seq_HELA_Human1.55603896
70FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55258124
71EED_16625203_ChIP-ChIP_MESCs_Mouse1.54140433
72EZH2_27294783_Chip-Seq_ESCs_Mouse1.53835749
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.51366274
74E2F1_21310950_ChIP-Seq_MCF-7_Human1.50967136
75MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.46598188
76NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.45894026
77BCAT_22108803_ChIP-Seq_LS180_Human1.45018534
78FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43722813
79ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.41997875
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.41843646
81SRF_21415370_ChIP-Seq_HL-1_Mouse1.41093375
82GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.39824549
83ESR1_21235772_ChIP-Seq_MCF-7_Human1.36628967
84IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.35686502
85CBP_20019798_ChIP-Seq_JUKART_Human1.35686502
86ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35464634
87GABP_19822575_ChIP-Seq_HepG2_Human1.35283907
88SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.35109372
89HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.34494252
90GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.34350031
91AHR_22903824_ChIP-Seq_MCF-7_Human1.34255631
92TCF4_18268006_ChIP-ChIP_LS174T_Human1.33295457
93PIAS1_25552417_ChIP-Seq_VCAP_Human1.32563546
94POU5F1_16153702_ChIP-ChIP_HESCs_Human1.32416348
95NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.32232942
96* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.32015013
97ARNT_22903824_ChIP-Seq_MCF-7_Human1.31488378
98MYCN_18555785_ChIP-Seq_MESCs_Mouse1.29798440
99TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.29676593
100BMI1_23680149_ChIP-Seq_NPCS_Mouse1.29296689
101SOX2_18555785_ChIP-Seq_MESCs_Mouse1.26954463
102KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26748133
103ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.24254180
104EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.23674783
105AR_21572438_ChIP-Seq_LNCaP_Human1.23170437
106TP53_20018659_ChIP-ChIP_R1E_Mouse1.22627027
107DCP1A_22483619_ChIP-Seq_HELA_Human1.22304543
108POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21456666
109PADI4_21655091_ChIP-ChIP_MCF-7_Human1.19166707
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15631318
111FLI1_27457419_Chip-Seq_LIVER_Mouse1.13892002
112SOX9_24532713_ChIP-Seq_HFSC_Mouse1.13755284
113SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.13163053
114RING1B_27294783_Chip-Seq_ESCs_Mouse1.12657014
115ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.11580404
116VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.11398429
117NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.09921798
118RING1B_27294783_Chip-Seq_NPCs_Mouse1.09419927
119* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.08805805
120IRF1_19129219_ChIP-ChIP_H3396_Human1.08307461
121PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08152856
122SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.06833711
123ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.05775506
124CIITA_25753668_ChIP-Seq_RAJI_Human1.04916588
125ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.04670133
126EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04614817
127VDR_22108803_ChIP-Seq_LS180_Human1.04448901
128P53_22127205_ChIP-Seq_FIBROBLAST_Human1.04347895
129CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02054118
130RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.01815071
131FUS_26573619_Chip-Seq_HEK293_Human1.01005688
132VDR_24787735_ChIP-Seq_THP-1_Human1.00930264
133TCF4_22108803_ChIP-Seq_LS180_Human1.00368690
134TP53_18474530_ChIP-ChIP_U2OS_Human1.00052515
135EGR1_19374776_ChIP-ChIP_THP-1_Human0.99661918
136ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.98976523
137AR_25329375_ChIP-Seq_VCAP_Human0.98941306
138NANOG_18555785_ChIP-Seq_MESCs_Mouse0.98189842
139WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97987455
140CTBP2_25329375_ChIP-Seq_LNCAP_Human0.97639393
141BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.97440246
142GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95870696
143TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.95628097
144NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.95530107
145BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95318274
146THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.94387123
147TCF3_18692474_ChIP-Seq_MEFs_Mouse0.93892633
148RUNX1_27514584_Chip-Seq_MCF-7_Human0.93793019
149RXR_22158963_ChIP-Seq_LIVER_Mouse0.93179415
150ELF1_17652178_ChIP-ChIP_JURKAT_Human0.92114324
151ZFX_18555785_ChIP-Seq_MESCs_Mouse0.91661819
152TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.91635962
153DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91389832
154E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.91290564
155KDM5A_27292631_Chip-Seq_BREAST_Human0.91214124
156NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90961133
157PHC1_16625203_ChIP-ChIP_MESCs_Mouse0.90690356
158FOXM1_26456572_ChIP-Seq_MCF-7_Human0.90516464
159SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90013726
160RCOR2_21632747_ChIP-Seq_MESCs_Mouse0.89834179
161FOXA2_19822575_ChIP-Seq_HepG2_Human0.89293073
162SOX2_20726797_ChIP-Seq_SW620_Human0.89210835
163EGR1_19032775_ChIP-ChIP_M12_Human0.88999343
164SMAD3_21741376_ChIP-Seq_EPCs_Human0.88771116
165TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88264040
166TP53_16413492_ChIP-PET_HCT116_Human0.88012180
167MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.87862808
168P300_19829295_ChIP-Seq_ESCs_Human0.87768717
169IRF8_27001747_Chip-Seq_BMDM_Mouse0.87759795
170ZNF274_21170338_ChIP-Seq_K562_Hela0.87534827
171SOX2_21211035_ChIP-Seq_LN229_Gbm0.87413632
172NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.86927617
173TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86695446
174TOP2B_26459242_ChIP-Seq_MCF-7_Human0.86445566
175EWS_26573619_Chip-Seq_HEK293_Human0.85775829
176TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.84940784
177STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.84234095
178IRF8_22096565_ChIP-ChIP_GC-B_Human0.84185440
179CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.84022820
180P63_26484246_Chip-Seq_KERATINOCYTES_Human0.82409663
181NR3C1_21868756_ChIP-Seq_MCF10A_Human0.82362952
182PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.82274955
183TP63_23658742_ChIP-Seq_EP156T_Human0.82091265
184IGF1R_20145208_ChIP-Seq_DFB_Human0.80882219
185SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.80166417
186NRF2_20460467_ChIP-Seq_MEFs_Mouse0.80144758
187NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.80144758
188ER_23166858_ChIP-Seq_MCF-7_Human0.80139292
189CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.80130596
190TCF3_18692474_ChIP-Seq_MESCs_Mouse0.77300688
191NFE2_27457419_Chip-Seq_LIVER_Mouse0.77262196
192ERG_20887958_ChIP-Seq_HPC-7_Mouse0.75898723
193TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.75825260
194PCGF2_27294783_Chip-Seq_ESCs_Mouse0.73653176
195FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.72890356
196PCGF2_27294783_Chip-Seq_NPCs_Mouse0.72006851
197SOX2_18692474_ChIP-Seq_MEFs_Mouse0.70857076

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001346_abnormal_lacrimal_gland6.03965283
2MP0001348_abnormal_lacrimal_gland5.34328370
3MP0002876_abnormal_thyroid_physiology5.13793548
4MP0003941_abnormal_skin_development4.01618302
5MP0008877_abnormal_DNA_methylation3.97071483
6MP0005645_abnormal_hypothalamus_physiol3.73677195
7MP0000685_abnormal_immune_system3.70291094
8MP0006292_abnormal_olfactory_placode3.40067561
9MP0003693_abnormal_embryo_hatching3.26511157
10MP0005310_abnormal_salivary_gland3.13842102
11MP0008058_abnormal_DNA_repair3.09266382
12MP0010094_abnormal_chromosome_stability3.06412204
13MP0001873_stomach_inflammation3.04285870
14MP0003111_abnormal_nucleus_morphology2.83800752
15MP0001835_abnormal_antigen_presentation2.73578439
16MP0004957_abnormal_blastocyst_morpholog2.71470243
17MP0003136_yellow_coat_color2.67221033
18MP0006035_abnormal_mitochondrial_morpho2.44541984
19MP0004510_myositis2.36894229
20MP0003077_abnormal_cell_cycle2.34449694
21MP0003718_maternal_effect2.31856974
22MP0002139_abnormal_hepatobiliary_system2.24548572
23MP0006082_CNS_inflammation2.23064414
24MP0001188_hyperpigmentation2.17924437
25MP0003890_abnormal_embryonic-extraembry2.15325125
26MP0006036_abnormal_mitochondrial_physio2.15126013
27MP0008007_abnormal_cellular_replicative2.14644984
28MP0001293_anophthalmia2.13747503
29MP0005365_abnormal_bile_salt2.11939345
30MP0003879_abnormal_hair_cell2.07198181
31MP0002254_reproductive_system_inflammat13.1590091
32MP0009379_abnormal_foot_pigmentation1.94810626
33MP0003567_abnormal_fetal_cardiomyocyte1.86081190
34MP0008057_abnormal_DNA_replication1.85906131
35MP0005367_renal/urinary_system_phenotyp1.80609290
36MP0000516_abnormal_urinary_system1.80609290
37MP0001501_abnormal_sleep_pattern1.78391737
38MP0000383_abnormal_hair_follicle1.75130863
39MP0009672_abnormal_birth_weight1.74669576
40MP0003186_abnormal_redox_activity1.74552656
41MP0005647_abnormal_sex_gland1.72539195
42MP0005085_abnormal_gallbladder_physiolo1.60525440
43MP0010678_abnormal_skin_adnexa1.59328584
44MP0003122_maternal_imprinting1.57652431
45MP0002938_white_spotting1.56829377
46MP0003453_abnormal_keratinocyte_physiol1.56091136
47MP0005332_abnormal_amino_acid1.55093542
48MP0000613_abnormal_salivary_gland1.54135591
49MP0008932_abnormal_embryonic_tissue1.47267946
50MP0002877_abnormal_melanocyte_morpholog1.44701301
51MP0004133_heterotaxia1.44665802
52MP0001984_abnormal_olfaction1.41771490
53MP0001529_abnormal_vocalization1.40653698
54MP0003787_abnormal_imprinting1.40465706
55MP0008875_abnormal_xenobiotic_pharmacok1.32942384
56MP0003806_abnormal_nucleotide_metabolis1.25297788
57MP0005377_hearing/vestibular/ear_phenot1.23324128
58MP0003878_abnormal_ear_physiology1.23324128
59MP0002277_abnormal_respiratory_mucosa1.23082169
60MP0001851_eye_inflammation1.22865370
61MP0010234_abnormal_vibrissa_follicle1.22754446
62MP0005671_abnormal_response_to1.21092459
63MP0004019_abnormal_vitamin_homeostasis1.20931414
64MP0010352_gastrointestinal_tract_polyps1.18126357
65MP0001730_embryonic_growth_arrest1.17343799
66MP0002735_abnormal_chemical_nociception1.16792729
67MP0003121_genomic_imprinting1.15754925
68MP0003011_delayed_dark_adaptation1.15304308
69MP0003763_abnormal_thymus_physiology1.14662980
70MP0006072_abnormal_retinal_apoptosis1.14547805
71MP0005360_urolithiasis1.14102292
72MP0003786_premature_aging1.13567642
73MP0000350_abnormal_cell_proliferation1.10409382
74MP0002210_abnormal_sex_determination1.09574539
75MP0001929_abnormal_gametogenesis1.08180206
76MP0001790_abnormal_immune_system1.07408344
77MP0005387_immune_system_phenotype1.07408344
78MP0003123_paternal_imprinting1.06792562
79MP0002653_abnormal_ependyma_morphology1.05887677
80MP0010030_abnormal_orbit_morphology1.05642887
81MP0000538_abnormal_urinary_bladder1.05088460
82MP0002396_abnormal_hematopoietic_system1.04530479
83MP0003183_abnormal_peptide_metabolism1.03118727
84MP0001145_abnormal_male_reproductive1.02866951
85MP0002138_abnormal_hepatobiliary_system1.02007527
86MP0003119_abnormal_digestive_system0.99290056
87MP0001666_abnormal_nutrient_absorption0.97266496
88MP0000470_abnormal_stomach_morphology0.96774304
89MP0000313_abnormal_cell_death0.95428748
90MP0003698_abnormal_male_reproductive0.93350629
91MP0001485_abnormal_pinna_reflex0.93305359
92MP0001286_abnormal_eye_development0.91939964
93MP0002090_abnormal_vision0.91808998
94MP0005395_other_phenotype0.90211515
95MP0005319_abnormal_enzyme/_coenzyme0.88631071
96MP0005394_taste/olfaction_phenotype0.88228586
97MP0005499_abnormal_olfactory_system0.88228586
98MP0001881_abnormal_mammary_gland0.87765000
99MP0001697_abnormal_embryo_size0.87187702
100MP0003938_abnormal_ear_development0.86389361
101MP0000653_abnormal_sex_gland0.86146446
102MP0002085_abnormal_embryonic_tissue0.84622544
103MP0004142_abnormal_muscle_tone0.83993709
104MP0005670_abnormal_white_adipose0.83392219
105MP0000049_abnormal_middle_ear0.83000784
106MP0003137_abnormal_impulse_conducting0.81974576
107MP0003937_abnormal_limbs/digits/tail_de0.81236313
108MP0002697_abnormal_eye_size0.80066047
109MP0002796_impaired_skin_barrier0.79747250
110MP0009703_decreased_birth_body0.79410966
111MP0003959_abnormal_lean_body0.78777300
112MP0003638_abnormal_response/metabolism_0.78657546
113MP0009745_abnormal_behavioral_response0.75813450
114MP0002160_abnormal_reproductive_system0.75499787
115MP0005084_abnormal_gallbladder_morpholo0.73140053
116MP0005379_endocrine/exocrine_gland_phen0.72842865
117MP0000579_abnormal_nail_morphology0.72351663
118MP0002084_abnormal_developmental_patter0.71095356
119MP0005551_abnormal_eye_electrophysiolog0.70204886
120MP0002233_abnormal_nose_morphology0.69835458
121MP0002736_abnormal_nociception_after0.69567182
122MP0009697_abnormal_copulation0.67496900
123MP0010155_abnormal_intestine_physiology0.67189761
124MP0000427_abnormal_hair_cycle0.67061926
125MP0001986_abnormal_taste_sensitivity0.66391080
126MP0002148_abnormal_hypersensitivity_rea0.65424242
127MP0005380_embryogenesis_phenotype0.64672307
128MP0001672_abnormal_embryogenesis/_devel0.64672307
129MP0003252_abnormal_bile_duct0.64030041
130MP0002111_abnormal_tail_morphology0.63655089
131MP0002080_prenatal_lethality0.63068459
132MP0002249_abnormal_larynx_morphology0.62916341
133MP0003045_fibrosis0.62007091
134MP0002909_abnormal_adrenal_gland0.61646770
135MP0005000_abnormal_immune_tolerance0.61551930
136MP0008872_abnormal_physiological_respon0.61431452
137MP0002733_abnormal_thermal_nociception0.60202396
138MP0002734_abnormal_mechanical_nocicepti0.59224582
139MP0002693_abnormal_pancreas_physiology0.58968028
140MP0000604_amyloidosis0.58488246
141MP0002405_respiratory_system_inflammati0.57920274
142MP0002098_abnormal_vibrissa_morphology0.57754165
143MP0000733_abnormal_muscle_development0.55406750
144MP0004859_abnormal_synaptic_plasticity0.52216614
145MP0001845_abnormal_inflammatory_respons0.52171838
146MP0001853_heart_inflammation0.51327748
147MP0003075_altered_response_to0.51227794
148MP0003329_amyloid_beta_deposits0.49726261
149MP0003195_calcinosis0.49353512
150MP0006276_abnormal_autonomic_nervous0.48479850
151MP0001663_abnormal_digestive_system0.48344764
152MP0001800_abnormal_humoral_immune0.46572979
153MP0005025_abnormal_response_to0.46530236
154MP0000003_abnormal_adipose_tissue0.46141618
155MP0005197_abnormal_uvea_morphology0.45295762
156MP0003300_gastrointestinal_ulcer0.44676616
157MP0001216_abnormal_epidermal_layer0.42413530
158MP0003705_abnormal_hypodermis_morpholog0.41165255
159MP0004270_analgesia0.40925007
160MP0002060_abnormal_skin_morphology0.39216747
161MP0000467_abnormal_esophagus_morphology0.39081994
162* MP0000703_abnormal_thymus_morphology0.38243579
163MP0001440_abnormal_grooming_behavior0.38231241
164MP0008789_abnormal_olfactory_epithelium0.38186999
165MP0004947_skin_inflammation0.37024996
166MP0008874_decreased_physiological_sensi0.36871629
167MP0004858_abnormal_nervous_system0.36538691
168MP0005623_abnormal_meninges_morphology0.35311197
169MP0005023_abnormal_wound_healing0.34430302
170MP0003091_abnormal_cell_migration0.34266630
171MP0005535_abnormal_body_temperature0.34206644
172MP0001764_abnormal_homeostasis0.33809218
173MP0005381_digestive/alimentary_phenotyp0.33623470
174MP0002837_dystrophic_cardiac_calcinosis0.32632570
175MP0010771_integument_phenotype0.32448029
176MP0003303_peritoneal_inflammation0.31904510
177MP0000639_abnormal_adrenal_gland0.31665757
178MP0000627_abnormal_mammary_gland0.31487101
179MP0002971_abnormal_brown_adipose0.31469637
180MP0008569_lethality_at_weaning0.31212272
181MP0009046_muscle_twitch0.30276291
182MP0004885_abnormal_endolymph0.30151180
183MP0009765_abnormal_xenobiotic_induced0.30106816
184MP0003448_altered_tumor_morphology0.29535036
185MP0002272_abnormal_nervous_system0.27657511
186MP0000762_abnormal_tongue_morphology0.27641653
187MP0004782_abnormal_surfactant_physiolog0.27527402
188MP0001970_abnormal_pain_threshold0.26805476
189MP0003635_abnormal_synaptic_transmissio0.26357116

Predicted human phenotypes

RankGene SetZ-score
1Chronic mucocutaneous candidiasis (HP:0002728)9.39360267
2Recurrent cutaneous fungal infections (HP:0011370)9.39360267
3Aplasia/Hypoplasia of the spleen (HP:0010451)6.94661393
4Keratoconjunctivitis (HP:0001096)6.71989277
5Asplenia (HP:0001746)6.29296115
6Congenital malformation of the right heart (HP:0011723)5.96860522
7Double outlet right ventricle (HP:0001719)5.96860522
8Right ventricular cardiomyopathy (HP:0011663)5.38365064
9Abnormality of calcium-phosphate metabolism (HP:0100530)5.22363632
10Type I diabetes mellitus (HP:0100651)5.08261350
11Colon cancer (HP:0003003)4.94102125
12Hypercortisolism (HP:0001578)4.92149364
13Recurrent fungal infections (HP:0002841)4.85123165
14Recurrent skin infections (HP:0001581)4.68312998
15Eczematoid dermatitis (HP:0000976)4.67035340
16Abnormality of the gastric mucosa (HP:0004295)4.52122427
17Lip pit (HP:0100267)4.11825519
18Severe visual impairment (HP:0001141)4.11064510
19Onycholysis (HP:0001806)4.08021422
20Hypoplasia of dental enamel (HP:0006297)3.80730376
21Acute necrotizing encephalopathy (HP:0006965)3.78556400
22Xerostomia (HP:0000217)3.78308151
23Truncus arteriosus (HP:0001660)3.78019669
24Cholelithiasis (HP:0001081)3.76807443
25Abnormal delayed hypersensitivity skin test (HP:0002963)3.75506448
26Prolonged partial thromboplastin time (HP:0003645)3.72161614
27Hypoparathyroidism (HP:0000829)3.71739455
28Milia (HP:0001056)3.69512413
29Acute encephalopathy (HP:0006846)3.58101739
30Hepatitis (HP:0012115)3.55907942
31Increased hepatocellular lipid droplets (HP:0006565)3.50908096
32Plantar hyperkeratosis (HP:0007556)3.45194229
33Hyperglycinemia (HP:0002154)3.42230749
34Abnormal gallbladder morphology (HP:0012437)3.41260896
35Septo-optic dysplasia (HP:0100842)3.41240226
36Abnormal mitochondria in muscle tissue (HP:0008316)3.24998966
37Upper limb muscle weakness (HP:0003484)3.21864128
38Abnormality of the labia minora (HP:0012880)3.21498684
39Colitis (HP:0002583)3.21019681
40Hyperglycinuria (HP:0003108)3.20663383
41Lipid accumulation in hepatocytes (HP:0006561)3.19566119
42Abnormal pupillary function (HP:0007686)3.07285741
43Abnormality of glycine metabolism (HP:0010895)3.06503404
44Abnormality of serine family amino acid metabolism (HP:0010894)3.06503404
45Decreased number of large peripheral myelinated nerve fibers (HP:0003387)3.04632443
46Type 2 muscle fiber atrophy (HP:0003554)3.03608126
47Mitochondrial inheritance (HP:0001427)3.01158931
48Progressive macrocephaly (HP:0004481)2.96116112
49Abnormality of the neuromuscular junction (HP:0003398)2.94585946
50Fatigable weakness (HP:0003473)2.94585946
51Agammaglobulinemia (HP:0004432)2.91811663
52Hydroxyprolinuria (HP:0003080)2.90950177
53Abnormality of proline metabolism (HP:0010907)2.90950177
54Panhypogammaglobulinemia (HP:0003139)2.90925709
55Increased CSF lactate (HP:0002490)2.85720948
56Interstitial pulmonary disease (HP:0006530)2.82165592
57Increased IgE level (HP:0003212)2.82057187
58Birth length less than 3rd percentile (HP:0003561)2.80394078
59Cerebral edema (HP:0002181)2.76757246
60Unilateral renal agenesis (HP:0000122)2.74127917
61Keratitis (HP:0000491)2.72212881
62Renal Fanconi syndrome (HP:0001994)2.67854622
63Muscle fiber atrophy (HP:0100295)2.64800282
64Alacrima (HP:0000522)2.64349634
65Megaloblastic anemia (HP:0001889)2.63690788
66Atrophic scars (HP:0001075)2.62437514
67Abnormality of serum amino acid levels (HP:0003112)2.60620334
68Reticulocytopenia (HP:0001896)2.58844829
69Macrocytic anemia (HP:0001972)2.57511093
70Palmoplantar hyperkeratosis (HP:0000972)2.55353280
71Abnormal lung lobation (HP:0002101)2.54969739
72Transposition of the great arteries (HP:0001669)2.54016653
73Abnormal connection of the cardiac segments (HP:0011545)2.54016653
74Abnormal ventriculo-arterial connection (HP:0011563)2.54016653
75Aplasia/Hypoplasia of the fovea (HP:0008060)2.52794947
76Hypoplasia of the fovea (HP:0007750)2.52794947
77IgM deficiency (HP:0002850)2.52362504
78Inflammation of the large intestine (HP:0002037)2.52238993
79Fragile nails (HP:0001808)2.52087567
80Amelogenesis imperfecta (HP:0000705)2.49651090
81Abnormality of small intestinal villus morphology (HP:0011472)2.47741497
82Villous atrophy (HP:0011473)2.47741497
83Abnormal number of erythroid precursors (HP:0012131)2.46216923
84Methylmalonic acidemia (HP:0002912)2.44775171
85Tongue fasciculations (HP:0001308)2.43436330
86Pancreatic islet-cell hyperplasia (HP:0004510)2.43159918
87Abnormality of homocysteine metabolism (HP:0010919)2.40708797
88Homocystinuria (HP:0002156)2.40708797
89Hypobetalipoproteinemia (HP:0003563)2.40561226
90Weak cry (HP:0001612)2.40406446
91Nasal polyposis (HP:0100582)2.39531875
92Abnormality of methionine metabolism (HP:0010901)2.37388570
93Adrenal overactivity (HP:0002717)2.36580749
94Hypoglycemic seizures (HP:0002173)2.36136949
95Abnormality of monocarboxylic acid metabolism (HP:0010996)2.35967319
96Exertional dyspnea (HP:0002875)2.35102804
97Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34420064
98Palmar hyperkeratosis (HP:0010765)2.32831719
99Methylmalonic aciduria (HP:0012120)2.30925753
100Gastrointestinal stroma tumor (HP:0100723)2.29405086
101Multiple enchondromatosis (HP:0005701)2.29374869
1023-Methylglutaconic aciduria (HP:0003535)2.28941659
103Recurrent gram-negative bacterial infections (HP:0005420)2.27167701
104Hepatocellular necrosis (HP:0001404)2.25177480
105Gastrointestinal inflammation (HP:0004386)2.24384280
106Mixed hearing impairment (HP:0000410)2.24049956
107Periauricular skin pits (HP:0100277)2.23031781
108Preauricular pit (HP:0004467)2.23031781
109Hypoglycemic coma (HP:0001325)2.22432413
110Abnormality of cells of the erythroid lineage (HP:0012130)2.21953195
111Meckel diverticulum (HP:0002245)2.21174154
112Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.20298375
113Optic nerve hypoplasia (HP:0000609)2.16859526
114Microvesicular hepatic steatosis (HP:0001414)2.16793461
115Abnormality of aspartate family amino acid metabolism (HP:0010899)2.16416578
116Muscle fibrillation (HP:0010546)2.15415193
117Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.14922227
118Decreased activity of mitochondrial respiratory chain (HP:0008972)2.14922227
119Viral hepatitis (HP:0006562)2.13505043
120Nasolacrimal duct obstruction (HP:0000579)2.12704622
121Type II lissencephaly (HP:0007260)2.11980897
122Cleft eyelid (HP:0000625)2.11239423
123Congenital stationary night blindness (HP:0007642)2.11122437
124Abnormal auditory evoked potentials (HP:0006958)2.09805602
125Neoplasm of the colon (HP:0100273)2.09746140
126Increased intramyocellular lipid droplets (HP:0012240)2.08649703
127Pili torti (HP:0003777)2.08388170
128Nail dystrophy (HP:0008404)2.07567259
129Abnormality of the gallbladder (HP:0005264)2.07006311
130Respiratory difficulties (HP:0002880)2.06334380
131Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.05952534
132Chronic otitis media (HP:0000389)2.05939850
133Leukodystrophy (HP:0002415)2.03454946
134Glycosuria (HP:0003076)2.03095172
135Abnormality of urine glucose concentration (HP:0011016)2.03095172
136Increased serum lactate (HP:0002151)2.02792479
137Abnormality of the fovea (HP:0000493)2.02760709
138Abnormality of pyrimidine metabolism (HP:0004353)2.02412346
139Chromosomal breakage induced by crosslinking agents (HP:0003221)2.02312559
140Abnormality of the ileum (HP:0001549)2.02122805
141Chromsome breakage (HP:0040012)2.02115949
142Palpitations (HP:0001962)2.01523581
143Hepatic necrosis (HP:0002605)2.01098042
144Hyperinsulinemic hypoglycemia (HP:0000825)2.00674327
145Neurofibrillary tangles (HP:0002185)2.00113805
146Decreased lacrimation (HP:0000633)1.99194279
147Abnormality of aromatic amino acid family metabolism (HP:0004338)1.99056896
148Maternal diabetes (HP:0009800)1.98990353
149Lactic acidosis (HP:0003128)1.98059849
150Hyperphosphaturia (HP:0003109)1.97726716
151Aplastic anemia (HP:0001915)1.95796027
152Anophthalmia (HP:0000528)1.95048566
153Premature loss of primary teeth (HP:0006323)1.94767914
154Choanal stenosis (HP:0000452)1.94194305
155Pallor (HP:0000980)1.93359515
156Aplasia cutis congenita (HP:0001057)1.93185834
157Hematochezia (HP:0002573)1.93008545
158Pustule (HP:0200039)1.92256867
159Abnormality of the lacrimal duct (HP:0011481)1.92009215
160Woolly hair (HP:0002224)1.91821100
161Abnormality of chromosome stability (HP:0003220)1.91475797
162Skin pits (HP:0100276)1.90913136
163Onion bulb formation (HP:0003383)1.90503048
164Abnormality of placental membranes (HP:0011409)1.89997725
165Amniotic constriction ring (HP:0009775)1.89997725
166Absent septum pellucidum (HP:0001331)1.88122940
167Aplasia/Hypoplasia of the uvula (HP:0010293)1.87776514
168Central scotoma (HP:0000603)1.87040707
169Esophageal varix (HP:0002040)1.87004156
170Nephroblastoma (Wilms tumor) (HP:0002667)1.85975417
171Cellular immunodeficiency (HP:0005374)1.85819888
172Lymphopenia (HP:0001888)1.84877875
173Lethargy (HP:0001254)1.84245995
174Gingivitis (HP:0000230)1.83547186
175Abnormal biliary tract physiology (HP:0012439)1.83026520
176Bile duct proliferation (HP:0001408)1.83026520
177Confusion (HP:0001289)1.81497240
178Cerebral inclusion bodies (HP:0100314)1.81461795
179Primary adrenal insufficiency (HP:0008207)1.81194356
180Osteomalacia (HP:0002749)1.80775967
181Abnormality of the nasal mucosa (HP:0000433)1.80458889
182Exercise intolerance (HP:0003546)1.80310277
183Recurrent bacterial skin infections (HP:0005406)1.80200010
184Abnormality of glutamine family amino acid metabolism (HP:0010902)1.80104984
185Bilateral microphthalmos (HP:0007633)1.78746760
186Abnormality of renal resorption (HP:0011038)1.78506076
187Aplasia/Hypoplasia affecting the fundus (HP:0008057)1.78268776
188Easy fatigability (HP:0003388)1.77659095
189Ventricular tachycardia (HP:0004756)1.77502056
190Type I transferrin isoform profile (HP:0003642)1.77391120
191Calf muscle hypertrophy (HP:0008981)1.75927033
192Recurrent sinusitis (HP:0011108)1.75820440
193Fragile skin (HP:0001030)1.73857141
194Abnormality of vitamin metabolism (HP:0100508)1.73704683
195Spontaneous abortion (HP:0005268)1.73688829
196Abnormality of sulfur amino acid metabolism (HP:0004339)1.73127345
197Decreased muscle mass (HP:0003199)1.68533225
198Rectal prolapse (HP:0002035)1.67903350
199Urticaria (HP:0001025)1.62103326
200Hypoplasia of the uterus (HP:0000013)1.60591800

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K145.57128056
2EPHA35.13783743
3CDK194.89192171
4BUB14.17450568
5CDC74.03380934
6VRK23.79938075
7EPHB13.73147178
8FGFR43.51762666
9NME13.50490580
10TTK3.11007122
11NLK3.02435066
12ZAK2.94982174
13MAPK152.82488124
14TAF12.50941653
15DYRK32.29120303
16STK162.23856412
17MAP3K132.17070582
18MKNK22.02473847
19PLK31.97435669
20TYK21.94642413
21WNK31.92169700
22VRK11.91409286
23PTK61.86619888
24BMPR1B1.82567487
25JAK31.82534888
26IRAK41.80006075
27PBK1.73620147
28TSSK61.65541630
29FGFR31.64395975
30SRPK11.61963767
31FER1.61470707
32PLK11.56385778
33CDC42BPA1.55115665
34MAP3K91.51008360
35MAP2K21.50866677
36DYRK1B1.46865958
37NEK11.46360199
38STK38L1.46054834
39PLK41.43079639
40GRK51.42483176
41ITK1.40528205
42BRD41.36624294
43PRKCI1.36075231
44CHUK1.35628047
45ERBB31.34174504
46IKBKE1.31617369
47TGFBR11.27827527
48NTRK11.25470749
49BTK1.24539457
50ATR1.24444576
51MAP3K101.21668630
52JAK21.19812343
53BCR1.17579460
54JAK11.16706869
55EPHA21.12881274
56MAP3K71.11696687
57NME21.08891274
58MST41.08753795
59MAP4K11.07378523
60SCYL21.06647979
61CSNK1G11.05724561
62NUAK11.05593478
63DDR21.05019933
64TBK11.04803107
65GRK11.03912701
66TLK11.02471820
67TNIK1.02372893
68STK41.01834452
69NEK21.01164204
70PTK20.99100245
71CHEK20.97787270
72MATK0.97475022
73CSNK1G20.96925005
74CASK0.96403152
75DAPK20.95180136
76IKBKB0.90857968
77RPS6KB20.90831915
78STK110.88865353
79LRRK20.88643137
80OXSR10.84297786
81AURKB0.83466667
82FGR0.82347427
83CDK80.81422436
84IRAK10.79367493
85ATM0.78916766
86BMPR20.75920142
87DYRK1A0.75688460
88CDK30.75008541
89CHEK10.74039058
90INSRR0.73074112
91PRKCG0.71328854
92EIF2AK30.71119398
93STK240.69867722
94ACVR1B0.68798020
95DYRK20.67473660
96SIK30.66061773
97MELK0.65790344
98CSNK1G30.64995461
99BLK0.64577367
100SIK20.62882294
101PNCK0.62784655
102MAPKAPK50.62483354
103CSF1R0.62280217
104MAP2K60.62059531
105BMX0.61152340
106TYRO30.60804702
107CSNK1A1L0.60667918
108CSNK2A20.60238023
109PASK0.59632946
110SIK10.59397459
111BRSK20.59301956
112CSNK1E0.58647964
113CAMK2G0.57360410
114FGFR10.57121069
115PRKD30.56447907
116SYK0.55418150
117CSNK2A10.55376988
118PDGFRA0.54239961
119MARK10.52689646
120ALK0.52658066
121CDK120.51747571
122CDK10.50742303
123STK30.49809791
124BRSK10.49806747
125TEC0.49666557
126TNK20.48821535
127HCK0.48686955
128BRAF0.48524753
129FGFR20.47084385
130CDK20.46929506
131TRIM280.46317326
132ARAF0.46053797
133CDK90.45764202
134MARK30.45651281
135EPHA40.45455116
136RET0.45266020
137CDK70.44776365
138IRAK30.44174407
139RIPK40.43564780
140UHMK10.43381601
141CDK40.42349024
142AURKA0.42090582
143CSNK1A10.41797158
144PRKCE0.41722406
145HIPK20.41513215
146PRKDC0.40505052
147SRC0.40414930
148LMTK20.39373909
149PRKCD0.39085070
150DAPK10.39072379
151CAMK2B0.39058095
152ERBB20.38528740
153ROCK20.38515105
154PRKAA20.37623120
155WNK40.37019747
156PKN10.36371799
157RPS6KA40.35274335
158MAP3K10.34865310
159TTN0.34829575
160PRKCQ0.34580683
161FES0.34531700
162MAP2K10.34270406
163NTRK20.33548636
164CAMK1G0.32642160
165PRKCB0.32255602
166BCKDK0.31861084
167EIF2AK20.31402025
168MAPKAPK20.30777478
169GRK70.30107521
170SMG10.29937925
171KIT0.28004082
172MKNK10.27852789
173RPS6KA50.27768205
174MAPK80.23346455
175PRKCZ0.21926951

Predicted pathways (KEGG)

RankGene SetZ-score
1Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004005.81403626
2Primary immunodeficiency_Homo sapiens_hsa053403.57313305
3Antigen processing and presentation_Homo sapiens_hsa046123.24234135
4Ribosome_Homo sapiens_hsa030103.08637481
5Arginine biosynthesis_Homo sapiens_hsa002203.02447999
6RNA polymerase_Homo sapiens_hsa030203.00109618
7Proteasome_Homo sapiens_hsa030502.93236247
8Oxidative phosphorylation_Homo sapiens_hsa001902.85258650
9Mismatch repair_Homo sapiens_hsa034302.80800116
10DNA replication_Homo sapiens_hsa030302.75635259
11Histidine metabolism_Homo sapiens_hsa003402.62689125
12Parkinsons disease_Homo sapiens_hsa050122.51127672
13Homologous recombination_Homo sapiens_hsa034402.49030353
14Asthma_Homo sapiens_hsa053102.42492722
15Intestinal immune network for IgA production_Homo sapiens_hsa046722.32672443
16Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.30834992
17Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.24648620
18Spliceosome_Homo sapiens_hsa030402.24222697
19One carbon pool by folate_Homo sapiens_hsa006702.15650447
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.12088240
21Base excision repair_Homo sapiens_hsa034101.93850650
22Cysteine and methionine metabolism_Homo sapiens_hsa002701.91485544
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.84854998
24Huntingtons disease_Homo sapiens_hsa050161.83715321
25Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.82643210
26Non-homologous end-joining_Homo sapiens_hsa034501.80534715
27Nicotine addiction_Homo sapiens_hsa050331.79149651
28NF-kappa B signaling pathway_Homo sapiens_hsa040641.75730639
29African trypanosomiasis_Homo sapiens_hsa051431.72380980
30RNA transport_Homo sapiens_hsa030131.68470689
31RNA degradation_Homo sapiens_hsa030181.68342153
32Leishmaniasis_Homo sapiens_hsa051401.67120226
33Phenylalanine metabolism_Homo sapiens_hsa003601.64188358
34Alzheimers disease_Homo sapiens_hsa050101.56387256
35Toxoplasmosis_Homo sapiens_hsa051451.50159710
36Protein export_Homo sapiens_hsa030601.47717470
37Pentose and glucuronate interconversions_Homo sapiens_hsa000401.44045102
38Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.42302608
39Vitamin B6 metabolism_Homo sapiens_hsa007501.41419239
40Dorso-ventral axis formation_Homo sapiens_hsa043201.41069713
41Amphetamine addiction_Homo sapiens_hsa050311.40134736
42Osteoclast differentiation_Homo sapiens_hsa043801.40133208
43Pyruvate metabolism_Homo sapiens_hsa006201.37105374
44Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.33947078
45Cardiac muscle contraction_Homo sapiens_hsa042601.29683171
46Biosynthesis of amino acids_Homo sapiens_hsa012301.28990368
47Retinol metabolism_Homo sapiens_hsa008301.26369198
48Cyanoamino acid metabolism_Homo sapiens_hsa004601.25333563
49Pyrimidine metabolism_Homo sapiens_hsa002401.23954934
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.23396302
51Selenocompound metabolism_Homo sapiens_hsa004501.22102080
52Graft-versus-host disease_Homo sapiens_hsa053321.21106250
53mRNA surveillance pathway_Homo sapiens_hsa030151.20131921
54Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.19217666
55Basal transcription factors_Homo sapiens_hsa030221.17383823
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.16108865
57Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.13932844
58Nucleotide excision repair_Homo sapiens_hsa034201.11044823
59Chemokine signaling pathway_Homo sapiens_hsa040621.10977383
60Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.09717575
61Fanconi anemia pathway_Homo sapiens_hsa034601.08931350
62Rheumatoid arthritis_Homo sapiens_hsa053231.06237966
63Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.05918470
64Propanoate metabolism_Homo sapiens_hsa006401.05887083
65Amoebiasis_Homo sapiens_hsa051461.05209025
66Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05128054
67Folate biosynthesis_Homo sapiens_hsa007901.04572005
68Small cell lung cancer_Homo sapiens_hsa052221.03481450
69Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.02956027
70Carbon metabolism_Homo sapiens_hsa012001.02644549
71Purine metabolism_Homo sapiens_hsa002301.01439135
72Cell cycle_Homo sapiens_hsa041101.01340071
73Allograft rejection_Homo sapiens_hsa053300.98442999
74Tryptophan metabolism_Homo sapiens_hsa003800.97418505
75Staphylococcus aureus infection_Homo sapiens_hsa051500.97175371
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94281842
77Drug metabolism - other enzymes_Homo sapiens_hsa009830.93579823
78Pancreatic cancer_Homo sapiens_hsa052120.90013343
79Taste transduction_Homo sapiens_hsa047420.89560257
80Glutathione metabolism_Homo sapiens_hsa004800.88698716
81ABC transporters_Homo sapiens_hsa020100.88255495
82Salivary secretion_Homo sapiens_hsa049700.87872646
83Chemical carcinogenesis_Homo sapiens_hsa052040.87595843
84Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86080116
85Olfactory transduction_Homo sapiens_hsa047400.83979553
86Linoleic acid metabolism_Homo sapiens_hsa005910.83354696
87Cocaine addiction_Homo sapiens_hsa050300.82230074
88Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.81316719
892-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.81174024
90Arginine and proline metabolism_Homo sapiens_hsa003300.80028819
91NOD-like receptor signaling pathway_Homo sapiens_hsa046210.78746065
92Calcium signaling pathway_Homo sapiens_hsa040200.76618223
93Systemic lupus erythematosus_Homo sapiens_hsa053220.75281042
94Tyrosine metabolism_Homo sapiens_hsa003500.74969256
95Glutamatergic synapse_Homo sapiens_hsa047240.74725365
96Serotonergic synapse_Homo sapiens_hsa047260.74523259
97Fatty acid degradation_Homo sapiens_hsa000710.74316426
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.74040918
99Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.73372035
100beta-Alanine metabolism_Homo sapiens_hsa004100.73325051
101Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73245300
102Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.72877729
103Metabolic pathways_Homo sapiens_hsa011000.72570496
104Tuberculosis_Homo sapiens_hsa051520.71769025
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.71016771
106Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.70563673
107Synaptic vesicle cycle_Homo sapiens_hsa047210.69868956
108Complement and coagulation cascades_Homo sapiens_hsa046100.69536628
109GABAergic synapse_Homo sapiens_hsa047270.69049719
110Pentose phosphate pathway_Homo sapiens_hsa000300.69041041
111Long-term potentiation_Homo sapiens_hsa047200.68475064
112TNF signaling pathway_Homo sapiens_hsa046680.67446673
113Legionellosis_Homo sapiens_hsa051340.67360837
114Melanoma_Homo sapiens_hsa052180.65816942
115MAPK signaling pathway_Homo sapiens_hsa040100.65548846
116Viral myocarditis_Homo sapiens_hsa054160.64893322
117Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.62825676
118Gastric acid secretion_Homo sapiens_hsa049710.62089661
119Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.62063381
120Fatty acid elongation_Homo sapiens_hsa000620.61706850
121Jak-STAT signaling pathway_Homo sapiens_hsa046300.61702869
122Epstein-Barr virus infection_Homo sapiens_hsa051690.60790563
123Maturity onset diabetes of the young_Homo sapiens_hsa049500.60764135
124Prolactin signaling pathway_Homo sapiens_hsa049170.60185991
125Peroxisome_Homo sapiens_hsa041460.60113147
126Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.60049267
127Pertussis_Homo sapiens_hsa051330.59166652
128Steroid hormone biosynthesis_Homo sapiens_hsa001400.58345565
129Type I diabetes mellitus_Homo sapiens_hsa049400.57757473
130Caffeine metabolism_Homo sapiens_hsa002320.56549369
131Circadian entrainment_Homo sapiens_hsa047130.56287806
132AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.55513466
133Apoptosis_Homo sapiens_hsa042100.55321588
134Butanoate metabolism_Homo sapiens_hsa006500.54602547
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.53304978
136Morphine addiction_Homo sapiens_hsa050320.53107864
137Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.52875366
138Oocyte meiosis_Homo sapiens_hsa041140.52857256
139Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50719948
140Pathways in cancer_Homo sapiens_hsa052000.50164414
141Autoimmune thyroid disease_Homo sapiens_hsa053200.48795441
142Lysine degradation_Homo sapiens_hsa003100.47297782
143Primary bile acid biosynthesis_Homo sapiens_hsa001200.45069418
144Ether lipid metabolism_Homo sapiens_hsa005650.44889502
145Ras signaling pathway_Homo sapiens_hsa040140.44629003
146VEGF signaling pathway_Homo sapiens_hsa043700.43074813
147Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.42078525
148Hippo signaling pathway_Homo sapiens_hsa043900.41984001
149RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41309492
150Phosphatidylinositol signaling system_Homo sapiens_hsa040700.41155556
151Steroid biosynthesis_Homo sapiens_hsa001000.40928762
152B cell receptor signaling pathway_Homo sapiens_hsa046620.40863838
153Adipocytokine signaling pathway_Homo sapiens_hsa049200.39789063
154Influenza A_Homo sapiens_hsa051640.39727531
155Arachidonic acid metabolism_Homo sapiens_hsa005900.39086295
156Chronic myeloid leukemia_Homo sapiens_hsa052200.37658136
157Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.36794939
158Estrogen signaling pathway_Homo sapiens_hsa049150.36720748
159Axon guidance_Homo sapiens_hsa043600.36082411
160Fat digestion and absorption_Homo sapiens_hsa049750.35786816
161GnRH signaling pathway_Homo sapiens_hsa049120.35751377
162Vitamin digestion and absorption_Homo sapiens_hsa049770.34876280
163Hepatitis B_Homo sapiens_hsa051610.34602788
164Type II diabetes mellitus_Homo sapiens_hsa049300.32437004
165Cholinergic synapse_Homo sapiens_hsa047250.31499589
166Leukocyte transendothelial migration_Homo sapiens_hsa046700.31344310
167Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.30638621
168Collecting duct acid secretion_Homo sapiens_hsa049660.30616516
169ECM-receptor interaction_Homo sapiens_hsa045120.29932131
170Herpes simplex infection_Homo sapiens_hsa051680.28480951
171Measles_Homo sapiens_hsa051620.28109960
172Starch and sucrose metabolism_Homo sapiens_hsa005000.27863897
173HTLV-I infection_Homo sapiens_hsa051660.27066246
174cAMP signaling pathway_Homo sapiens_hsa040240.26749706
175Melanogenesis_Homo sapiens_hsa049160.25973021
176Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.25959144
177ErbB signaling pathway_Homo sapiens_hsa040120.25165508
178Regulation of actin cytoskeleton_Homo sapiens_hsa048100.24951211

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