CRIPAK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: CRIPAK is a negative regulator of PAK1 (MIM 602590) that is upregulated by estrogen (Talukder et al., 2006 [PubMed 16278681]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of CREB transcription factor activity (GO:0032793)4.22065577
2negative regulation of cAMP-mediated signaling (GO:0043951)4.01612330
3alkaloid metabolic process (GO:0009820)3.82087218
4positive regulation of histone deacetylation (GO:0031065)3.71011075
5hydrogen peroxide biosynthetic process (GO:0050665)3.45605375
6regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.43734449
7regulation of ARF GTPase activity (GO:0032312)3.41987283
8regulation of hydrogen peroxide metabolic process (GO:0010310)3.40961522
9head development (GO:0060322)3.31684577
10sulfate transmembrane transport (GO:1902358)3.25836667
11histone H3-K9 modification (GO:0061647)3.24928682
12mannose metabolic process (GO:0006013)3.23916187
13embryonic retina morphogenesis in camera-type eye (GO:0060059)3.17101197
14intraciliary transport (GO:0042073)3.17044968
15oxidative demethylation (GO:0070989)3.12633412
16epoxygenase P450 pathway (GO:0019373)3.12038053
17meiotic chromosome segregation (GO:0045132)3.11212832
18glycerophospholipid catabolic process (GO:0046475)3.10227393
19histone H3-K4 trimethylation (GO:0080182)3.08027296
20activated T cell proliferation (GO:0050798)3.07885251
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.07678963
22negative regulation of cell killing (GO:0031342)3.07678963
23epithelial cilium movement (GO:0003351)3.07388516
24histone H3-K9 methylation (GO:0051567)3.06760336
25body morphogenesis (GO:0010171)3.02526276
26drug catabolic process (GO:0042737)3.00409859
27ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043162.99299339
28reactive oxygen species biosynthetic process (GO:1903409)2.98202461
29histone H3-K9 demethylation (GO:0033169)2.93463528
30tachykinin receptor signaling pathway (GO:0007217)2.93303134
31tongue development (GO:0043586)2.90200755
32exogenous drug catabolic process (GO:0042738)2.84919879
33diacylglycerol metabolic process (GO:0046339)2.84474672
34regulation of histone deacetylation (GO:0031063)2.81601402
35positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.81277644
36cell migration in hindbrain (GO:0021535)2.80787881
37nephron tubule morphogenesis (GO:0072078)2.80671920
38nephron epithelium morphogenesis (GO:0072088)2.80671920
39establishment of protein localization to Golgi (GO:0072600)2.80073198
40embryonic body morphogenesis (GO:0010172)2.79784712
41epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.79413988
42histone H4 deacetylation (GO:0070933)2.77712375
43nonmotile primary cilium assembly (GO:0035058)2.77098260
44positive regulation of sodium ion transmembrane transporter activity (GO:2000651)2.76082943
45sulfate transport (GO:0008272)2.75390282
46histone H3 deacetylation (GO:0070932)2.73622451
47positive regulation of protein deacetylation (GO:0090312)2.69830482
48positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.66225763
49cilium movement (GO:0003341)2.64855381
50histone H2A monoubiquitination (GO:0035518)2.57992735
51protein localization to Golgi apparatus (GO:0034067)2.57956736
52protein localization to cilium (GO:0061512)2.57455534
53negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.55345779
54negative regulation of granulocyte differentiation (GO:0030853)2.54314042
55protein targeting to Golgi (GO:0000042)2.50406284
56left/right axis specification (GO:0070986)2.50101016
57response to gravity (GO:0009629)2.42574169
58white fat cell differentiation (GO:0050872)2.41262549
59positive regulation of triglyceride biosynthetic process (GO:0010867)2.40734335
60regulation of microtubule-based movement (GO:0060632)2.40558808
61retrograde transport, vesicle recycling within Golgi (GO:0000301)2.38371008
62positive regulation of protein kinase C signaling (GO:0090037)2.35083553
63cilium morphogenesis (GO:0060271)2.34102835
64negative regulation of Rho protein signal transduction (GO:0035024)2.33340583
65establishment of mitochondrion localization (GO:0051654)2.32456463
66phenylpropanoid metabolic process (GO:0009698)2.30247925
67negative regulation of glial cell proliferation (GO:0060253)2.28039407
68omega-hydroxylase P450 pathway (GO:0097267)2.27745308
69positive regulation of sodium ion transmembrane transport (GO:1902307)2.27650049
70tolerance induction (GO:0002507)2.26636641
71cell proliferation in forebrain (GO:0021846)2.26607825
72negative regulation of glycoprotein biosynthetic process (GO:0010561)2.26264961
73hypothalamus development (GO:0021854)2.26251687
74regulation of glycogen (starch) synthase activity (GO:2000465)2.24758305
75regulation of respiratory burst (GO:0060263)2.24658361
76adaptation of signaling pathway (GO:0023058)2.24604206
77parturition (GO:0007567)2.23665518
78axonal fasciculation (GO:0007413)2.22261568
79urogenital system development (GO:0001655)2.20922103
80regulation of cilium movement (GO:0003352)2.19143796
81camera-type eye morphogenesis (GO:0048593)2.19115151
82cardiovascular system development (GO:0072358)2.18716877
83negative regulation of immunoglobulin mediated immune response (GO:0002890)2.17634802
84negative regulation of B cell mediated immunity (GO:0002713)2.17634802
85adenylate cyclase-activating dopamine receptor signaling pathway (GO:0007191)2.16488860
86adult walking behavior (GO:0007628)2.16422242
87cell-cell junction maintenance (GO:0045217)2.16302563
88auditory receptor cell differentiation (GO:0042491)2.15199255
89synaptic transmission, dopaminergic (GO:0001963)2.12506360
90negative regulation of lymphocyte mediated immunity (GO:0002707)2.11423827
91brain morphogenesis (GO:0048854)2.10909039
92phosphatidylcholine biosynthetic process (GO:0006656)2.09936967
93neuronal stem cell maintenance (GO:0097150)2.09440487
94cilium or flagellum-dependent cell motility (GO:0001539)2.08279721
95macroautophagy (GO:0016236)2.07556477
96mitochondrion transport along microtubule (GO:0047497)2.06978626
97establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.06978626
98heart valve formation (GO:0003188)2.06105469
99substrate-independent telencephalic tangential interneuron migration (GO:0021843)2.06068961
100substrate-independent telencephalic tangential migration (GO:0021826)2.06068961

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.80771914
2DROSHA_22980978_ChIP-Seq_HELA_Human2.72301593
3THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.59874902
4* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.32900030
5IKZF1_21737484_ChIP-ChIP_HCT116_Human2.07943712
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.93666309
7EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.88107908
8EZH2_27294783_Chip-Seq_ESCs_Mouse1.64863198
9CTCF_27219007_Chip-Seq_Bcells_Human1.56296946
10SUZ12_27294783_Chip-Seq_ESCs_Mouse1.56180944
11REST_21632747_ChIP-Seq_MESCs_Mouse1.55920844
12BCL6_27268052_Chip-Seq_Bcells_Human1.54631421
13RNF2_27304074_Chip-Seq_ESCs_Mouse1.52516604
14KDM2B_26808549_Chip-Seq_SUP-B15_Human1.47579436
15P68_20966046_ChIP-Seq_HELA_Human1.44654609
16RBPJ_22232070_ChIP-Seq_NCS_Mouse1.43725810
17NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.38963113
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.37878883
19DNAJC2_21179169_ChIP-ChIP_NT2_Human1.37854347
20TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.37706698
21SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.33156384
22KDM2B_26808549_Chip-Seq_K562_Human1.33083134
23LXR_22292898_ChIP-Seq_THP-1_Human1.28725531
24* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.26635009
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.26357789
26* OCT4_19829295_ChIP-Seq_ESCs_Human1.26074039
27* SMC4_20622854_ChIP-Seq_HELA_Human1.23065189
28ERG_21242973_ChIP-ChIP_JURKAT_Human1.21554908
29JARID2_20064375_ChIP-Seq_MESCs_Mouse1.21039433
30KDM2B_26808549_Chip-Seq_DND41_Human1.20367162
31CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.19833684
32STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.19310139
33JARID2_20075857_ChIP-Seq_MESCs_Mouse1.18276585
34BCAT_22108803_ChIP-Seq_LS180_Human1.17126361
35REST_18959480_ChIP-ChIP_MESCs_Mouse1.17081303
36BCOR_27268052_Chip-Seq_Bcells_Human1.16522814
37GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.15627092
38ZNF274_21170338_ChIP-Seq_K562_Hela1.13216320
39E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.11103185
40* SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.10443619
41PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.10175837
42ERA_21632823_ChIP-Seq_H3396_Human1.09451574
43TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08965043
44POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08965043
45EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.08889621
46PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08822226
47* PHF8_20622854_ChIP-Seq_HELA_Human1.08439168
48E2F1_20622854_ChIP-Seq_HELA_Human1.08185692
49WT1_25993318_ChIP-Seq_PODOCYTE_Human1.07399562
50* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07366761
51ESR1_20079471_ChIP-ChIP_T-47D_Human1.06065685
52TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.05244788
53MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.05061469
54MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.04923633
55EZH2_27304074_Chip-Seq_ESCs_Mouse1.04401892
56AHR_22903824_ChIP-Seq_MCF-7_Human1.03568729
57GATA1_19941827_ChIP-Seq_MEL_Mouse1.03248170
58MTF2_20144788_ChIP-Seq_MESCs_Mouse1.02315960
59RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.02058000
60CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01149289
61KDM2B_26808549_Chip-Seq_JURKAT_Human1.00657671
62OCT4_20526341_ChIP-Seq_ESCs_Human1.00620171
63GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.98250450
64FOXA2_19822575_ChIP-Seq_HepG2_Human0.98072675
65ESR2_21235772_ChIP-Seq_MCF-7_Human0.97650882
66TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97159565
67OLIG2_26023283_ChIP-Seq_AINV15_Mouse0.97094417
68GLI1_17442700_ChIP-ChIP_MESCs_Mouse0.96512018
69TP63_22573176_ChIP-Seq_HFKS_Human0.96401460
70ELK4_26923725_Chip-Seq_MESODERM_Mouse0.95891471
71RBPJ_21746931_ChIP-Seq_IB4-LCL_Human0.93796648
72RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.93317259
73LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.93194777
74RXR_22108803_ChIP-Seq_LS180_Human0.91751267
75MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human0.90033479
76KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89850641
77RING1B_27294783_Chip-Seq_ESCs_Mouse0.89088606
78SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.88996805
79RUNX_20019798_ChIP-Seq_JUKART_Human0.88541695
80NEUROD2_26341353_ChIP-Seq_CORTEX_Mouse0.88361517
81VDR_22108803_ChIP-Seq_LS180_Human0.88161444
82* KLF4_19829295_ChIP-Seq_ESCs_Human0.88120229
83RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88090623
84CREB1_26743006_Chip-Seq_LNCaP_Human0.88070522
85KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87278567
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.86938463
87VDR_21846776_ChIP-Seq_THP-1_Human0.86922782
88P63_20808887_ChIP-Seq_KERATINOCYTES_Human0.86879401
89SPI1_23127762_ChIP-Seq_K562_Human0.85870429
90RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.84708812
91SA1_27219007_Chip-Seq_Bcells_Human0.84531719
92CTNNB1_20460455_ChIP-Seq_HCT116_Human0.84197855
93MYC_27129775_Chip-Seq_CORNEA_Mouse0.82271360
94AR_19668381_ChIP-Seq_PC3_Human0.81961830
95TET1_21490601_ChIP-Seq_MESCs_Mouse0.81362207
96ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80239508
97ARNT_22903824_ChIP-Seq_MCF-7_Human0.79357641
98GBX2_23144817_ChIP-Seq_PC3_Human0.79187900
99ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.78121677
100EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.77661889

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.59252418
2MP0000569_abnormal_digit_pigmentation3.39721056
3MP0006292_abnormal_olfactory_placode3.31705212
4MP0002653_abnormal_ependyma_morphology3.16103501
5MP0003172_abnormal_lysosome_physiology3.04072248
6MP0003878_abnormal_ear_physiology2.99406810
7MP0005377_hearing/vestibular/ear_phenot2.99406810
8MP0003123_paternal_imprinting2.34939151
9MP0003122_maternal_imprinting2.19182989
10MP0008875_abnormal_xenobiotic_pharmacok2.03160903
11MP0003136_yellow_coat_color2.03104761
12MP0000778_abnormal_nervous_system1.94356410
13MP0004043_abnormal_pH_regulation1.85858680
14MP0004133_heterotaxia1.76839255
15MP0000566_synostosis1.71336688
16MP0005360_urolithiasis1.66897192
17MP0002928_abnormal_bile_duct1.62794648
18MP0003880_abnormal_central_pattern1.61445873
19MP0002249_abnormal_larynx_morphology1.61115287
20MP0003183_abnormal_peptide_metabolism1.59179930
21MP0003121_genomic_imprinting1.58924179
22MP0005551_abnormal_eye_electrophysiolog1.58192774
23MP0008877_abnormal_DNA_methylation1.57885264
24MP0003724_increased_susceptibility_to1.52031422
25MP0004381_abnormal_hair_follicle1.51292759
26MP0002822_catalepsy1.48915525
27MP0001986_abnormal_taste_sensitivity1.48485291
28MP0000015_abnormal_ear_pigmentation1.47153459
29MP0005499_abnormal_olfactory_system1.46002218
30MP0005394_taste/olfaction_phenotype1.46002218
31MP0003195_calcinosis1.43493833
32MP0005365_abnormal_bile_salt1.39395128
33MP0004859_abnormal_synaptic_plasticity1.38912370
34MP0008789_abnormal_olfactory_epithelium1.31373620
35MP0001502_abnormal_circadian_rhythm1.29103334
36MP0002102_abnormal_ear_morphology1.27123492
37MP0002138_abnormal_hepatobiliary_system1.26264886
38MP0001970_abnormal_pain_threshold1.25975781
39MP0003252_abnormal_bile_duct1.20353221
40MP0002733_abnormal_thermal_nociception1.20149851
41MP0010329_abnormal_lipoprotein_level1.20025658
42MP0002063_abnormal_learning/memory/cond1.16654307
43MP0004142_abnormal_muscle_tone1.14674674
44MP0002876_abnormal_thyroid_physiology1.14507231
45MP0008872_abnormal_physiological_respon1.12534053
46MP0003879_abnormal_hair_cell1.10476376
47MP0005670_abnormal_white_adipose1.10379957
48MP0002572_abnormal_emotion/affect_behav1.09746612
49MP0002735_abnormal_chemical_nociception1.09090447
50MP0001984_abnormal_olfaction1.08490304
51MP0002557_abnormal_social/conspecific_i1.05524123
52MP0003436_decreased_susceptibility_to1.05297365
53MP0001968_abnormal_touch/_nociception1.05208451
54MP0001486_abnormal_startle_reflex1.02015954
55MP0003866_abnormal_defecation1.01138268
56MP0004782_abnormal_surfactant_physiolog1.00297778
57MP0002933_joint_inflammation1.00107684
58MP0003938_abnormal_ear_development0.97478748
59MP0005174_abnormal_tail_pigmentation0.96041945
60MP0005448_abnormal_energy_balance0.94537502
61MP0009278_abnormal_bone_marrow0.94398411
62MP0002067_abnormal_sensory_capabilities0.94012678
63MP0000955_abnormal_spinal_cord0.93438660
64MP0000026_abnormal_inner_ear0.92740120
65MP0001663_abnormal_digestive_system0.92612473
66MP0003011_delayed_dark_adaptation0.91661700
67MP0004130_abnormal_muscle_cell0.89081570
68MP0010030_abnormal_orbit_morphology0.87563089
69MP0005535_abnormal_body_temperature0.86385925
70MP0003635_abnormal_synaptic_transmissio0.86076629
71MP0003646_muscle_fatigue0.84095309
72MP0000631_abnormal_neuroendocrine_gland0.83951389
73MP0002752_abnormal_somatic_nervous0.83049494
74MP0008995_early_reproductive_senescence0.82499445
75MP0001485_abnormal_pinna_reflex0.80570591
76MP0006276_abnormal_autonomic_nervous0.79685937
77MP0005075_abnormal_melanosome_morpholog0.79350890
78MP0000427_abnormal_hair_cycle0.78574738
79MP0001293_anophthalmia0.78507262
80MP0009745_abnormal_behavioral_response0.78412245
81MP0003943_abnormal_hepatobiliary_system0.78299170
82MP0002277_abnormal_respiratory_mucosa0.77343094
83MP0001324_abnormal_eye_pigmentation0.76445834
84MP0002932_abnormal_joint_morphology0.76125538
85MP0002229_neurodegeneration0.74692332
86MP0005646_abnormal_pituitary_gland0.74311170
87MP0002078_abnormal_glucose_homeostasis0.73623119
88MP0002882_abnormal_neuron_morphology0.73549518
89MP0005195_abnormal_posterior_eye0.73425584
90MP0000230_abnormal_systemic_arterial0.72225447
91MP0002272_abnormal_nervous_system0.71238145
92MP0005248_abnormal_Harderian_gland0.71102194
93MP0000678_abnormal_parathyroid_gland0.70479502
94MP0002152_abnormal_brain_morphology0.69264639
95MP0005666_abnormal_adipose_tissue0.69118692
96MP0005381_digestive/alimentary_phenotyp0.68996401
97MP0001765_abnormal_ion_homeostasis0.68056846
98MP0001501_abnormal_sleep_pattern0.65480527
99MP0000371_diluted_coat_color0.65428404
100MP0004924_abnormal_behavior0.64937132

Predicted human phenotypes

RankGene SetZ-score
1Chronic hepatic failure (HP:0100626)3.89311088
2Cystic liver disease (HP:0006706)3.76201820
3Severe visual impairment (HP:0001141)3.65143522
4Pancreatic fibrosis (HP:0100732)3.61338204
5Abnormality of midbrain morphology (HP:0002418)3.56317818
6Molar tooth sign on MRI (HP:0002419)3.56317818
7Nephronophthisis (HP:0000090)3.53364514
8True hermaphroditism (HP:0010459)3.21259285
9Abnormality of the renal medulla (HP:0100957)3.00953163
10Rib fusion (HP:0000902)2.98996473
11Pancreatic cysts (HP:0001737)2.96255565
12Gait imbalance (HP:0002141)2.90667984
13Papilledema (HP:0001085)2.87347249
14Obstructive sleep apnea (HP:0002870)2.84178002
15Aplasia/Hypoplasia of the pubic bone (HP:0009104)2.75022474
16Medial flaring of the eyebrow (HP:0010747)2.71248996
17Genetic anticipation (HP:0003743)2.60709025
18J-shaped sella turcica (HP:0002680)2.60310141
19Abnormality of the aortic arch (HP:0012303)2.59447740
20Occipital encephalocele (HP:0002085)2.52054293
21Congenital primary aphakia (HP:0007707)2.49396523
22Hyperthyroidism (HP:0000836)2.48856595
23Myokymia (HP:0002411)2.43507791
24Hypoplastic ischia (HP:0003175)2.38565996
25Oligodactyly (hands) (HP:0001180)2.33227221
26Cervical subluxation (HP:0003308)2.30915234
27Renal dysplasia (HP:0000110)2.29622833
28Congenital hepatic fibrosis (HP:0002612)2.29013753
29Polyphagia (HP:0002591)2.25629138
30Abnormal rod and cone electroretinograms (HP:0008323)2.24589339
31Tubular atrophy (HP:0000092)2.23277172
32Vitreoretinal degeneration (HP:0000655)2.22934198
33Nephrogenic diabetes insipidus (HP:0009806)2.22851779
34Aplasia/Hypoplasia of the spleen (HP:0010451)2.21769631
35Hyperkalemia (HP:0002153)2.15625816
36Anencephaly (HP:0002323)2.09726815
37Gingivitis (HP:0000230)2.09622305
38Asplenia (HP:0001746)2.08311422
39Atelectasis (HP:0100750)2.08132204
40Truncus arteriosus (HP:0001660)2.07993090
41Dynein arm defect of respiratory motile cilia (HP:0012255)2.07120222
42Absent/shortened dynein arms (HP:0200106)2.07120222
43Sleep apnea (HP:0010535)2.06691696
44Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.06596189
45Progressive cerebellar ataxia (HP:0002073)2.05038414
46Postaxial foot polydactyly (HP:0001830)2.05027567
47Supranuclear gaze palsy (HP:0000605)2.04319974
48Poor coordination (HP:0002370)2.03491459
49Abnormality of polysaccharide metabolism (HP:0011012)2.03050921
50Abnormality of glycosaminoglycan metabolism (HP:0004371)2.03050921
51Abnormality of mucopolysaccharide metabolism (HP:0011020)2.03050921
52Prolonged bleeding time (HP:0003010)2.01883151
53Tubulointerstitial nephritis (HP:0001970)2.01787350
54Oligodactyly (HP:0012165)2.01546187
55Recurrent gram-negative bacterial infections (HP:0005420)1.97262218
56Mucopolysacchariduria (HP:0008155)1.92972697
57Urinary glycosaminoglycan excretion (HP:0003541)1.92972697
58Macroorchidism (HP:0000053)1.91209829
59Flared iliac wings (HP:0002869)1.90815813
60Abnormality of the renal cortex (HP:0011035)1.89928733
61Thin bony cortex (HP:0002753)1.88441276
62Short foot (HP:0001773)1.88227452
63Aplasia/Hypoplasia of the tongue (HP:0010295)1.88115623
64Flattened epiphyses (HP:0003071)1.86222351
65Tented upper lip vermilion (HP:0010804)1.84491221
66Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.83499854
67Metaphyseal cupping (HP:0003021)1.82761134
68Abnormality of the ischium (HP:0003174)1.82000647
69Abnormal drinking behavior (HP:0030082)1.80752245
70Polydipsia (HP:0001959)1.80752245
71Optic nerve coloboma (HP:0000588)1.80526146
72Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)1.78442783
73Disproportionate short-trunk short stature (HP:0003521)1.77800787
74Abnormal delayed hypersensitivity skin test (HP:0002963)1.77152627
75Congenital stationary night blindness (HP:0007642)1.76503118
76Hypochromic anemia (HP:0001931)1.75412460
77Sclerocornea (HP:0000647)1.73551929
7811 pairs of ribs (HP:0000878)1.73079368
79Abnormal pancreas size (HP:0012094)1.72955600
80Septo-optic dysplasia (HP:0100842)1.71422286
81Abnormality of DNA repair (HP:0003254)1.70852263
82Hyperventilation (HP:0002883)1.70465610
83Stage 5 chronic kidney disease (HP:0003774)1.70386111
84Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.69619869
85Hypochromic microcytic anemia (HP:0004840)1.69330394
86Agitation (HP:0000713)1.69273409
87Abnormality of chloride homeostasis (HP:0011422)1.69081815
88Oligodontia (HP:0000677)1.67657922
89Bile duct proliferation (HP:0001408)1.67560437
90Abnormal biliary tract physiology (HP:0012439)1.67560437
91Supernumerary bones of the axial skeleton (HP:0009144)1.67473286
92Abnormality of the femoral head (HP:0003368)1.67253446
93Specific learning disability (HP:0001328)1.66527781
94Mitral regurgitation (HP:0001653)1.66515385
95Postaxial hand polydactyly (HP:0001162)1.66401821
96Male pseudohermaphroditism (HP:0000037)1.66149016
97Abnormality of lateral ventricle (HP:0030047)1.65814309
98Abnormal eating behavior (HP:0100738)1.65189020
99Genital tract atresia (HP:0001827)1.65085420
100Broad alveolar ridges (HP:0000187)1.64878041

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SIK23.14182548
2TNK23.05644827
3WNK42.85885137
4SIK12.65000518
5FRK2.28782221
6NTRK32.25029543
7MARK22.12543217
8CASK2.08560648
9TNIK2.08114146
10TAOK31.92732278
11MAP3K61.89223698
12PRKD31.69188403
13NTRK21.64367258
14MAP3K71.63447118
15MAP4K11.52780890
16MAP2K61.51378903
17WNK11.50618821
18PRKD21.42886082
19PRKCH1.40034677
20ERN11.37074213
21MAP3K111.34191612
22SIK31.31254481
23TYRO31.25619227
24MAP4K21.20600021
25FES1.20577069
26MAP3K131.14690050
27CAMKK11.13273112
28PTK2B1.12407308
29DAPK21.07622297
30MAPK131.03652710
31MAP2K31.02700393
32PTK60.99344544
33RPS6KA20.99254002
34GRK60.96895730
35NLK0.96285302
36RIPK40.94174293
37MAP2K40.93904895
38DYRK1B0.93337952
39MAP3K20.92984579
40MAP3K90.92873972
41CAMK1G0.92872137
42CDC42BPA0.89688352
43EPHA40.87176769
44CSK0.86442345
45SGK20.85767381
46MAPK150.85268308
47ZAP700.85229980
48TYK20.85161060
49PAK30.82684553
50STK110.82478912
51SGK4940.82062427
52SGK2230.82062427
53ACVR1B0.81693872
54TXK0.80048539
55NTRK10.79442992
56BLK0.79317839
57MARK10.78947516
58MARK30.78467571
59TLK10.77905822
60MET0.75279149
61CSF1R0.75239316
62PNCK0.74355684
63RPS6KA60.74321806
64PRKCZ0.73773796
65ERBB20.73640274
66RPS6KL10.72922336
67RPS6KC10.72922336
68HIPK20.71400420
69BMPR1B0.71073590
70MAPK120.70028429
71ADRBK20.69632822
72BMX0.69278825
73TRIB30.69261098
74CAMK10.67491997
75NME10.67120112
76PDGFRB0.64982418
77GRK10.64204578
78ICK0.63221175
79EPHB20.63148364
80DYRK1A0.63065766
81CAMK1D0.62648675
82TAOK10.62562463
83SGK30.62269799
84FGR0.61967179
85PINK10.58977544
86ITK0.58069794
87SGK10.57520397
88ADRBK10.57153595
89LCK0.56574899
90PRKAA20.56194558
91DYRK20.55926883
92AKT30.53687423
93STK380.52589806
94BTK0.52040099
95EPHB10.51999058
96MST1R0.51822513
97PHKG20.49181450
98PHKG10.49181450
99HCK0.47471083
100RIPK10.47292238

Predicted pathways (KEGG)

RankGene SetZ-score
1Caffeine metabolism_Homo sapiens_hsa002324.68564579
2Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.48015943
3Linoleic acid metabolism_Homo sapiens_hsa005912.33664194
4Notch signaling pathway_Homo sapiens_hsa043302.23376595
5Other glycan degradation_Homo sapiens_hsa005112.00823548
6Cyanoamino acid metabolism_Homo sapiens_hsa004601.88663635
7Dorso-ventral axis formation_Homo sapiens_hsa043201.86900078
8alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.56142761
9ABC transporters_Homo sapiens_hsa020101.52468238
10Glycosaminoglycan degradation_Homo sapiens_hsa005311.45376767
11Glycerophospholipid metabolism_Homo sapiens_hsa005641.44189114
12Ether lipid metabolism_Homo sapiens_hsa005651.38712597
13Glycerolipid metabolism_Homo sapiens_hsa005611.36680492
14Basal cell carcinoma_Homo sapiens_hsa052171.33390870
15Insulin secretion_Homo sapiens_hsa049111.26826581
16Choline metabolism in cancer_Homo sapiens_hsa052311.20930631
17Phospholipase D signaling pathway_Homo sapiens_hsa040721.16512026
18Aldosterone synthesis and secretion_Homo sapiens_hsa049251.14885246
19Carbohydrate digestion and absorption_Homo sapiens_hsa049731.11264022
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.10120741
21Phosphatidylinositol signaling system_Homo sapiens_hsa040701.08270184
22Staphylococcus aureus infection_Homo sapiens_hsa051501.06922441
23Phototransduction_Homo sapiens_hsa047441.05463550
24Axon guidance_Homo sapiens_hsa043601.03862753
25VEGF signaling pathway_Homo sapiens_hsa043701.01555966
26Vascular smooth muscle contraction_Homo sapiens_hsa042700.99618080
27Regulation of autophagy_Homo sapiens_hsa041400.99289800
28Hedgehog signaling pathway_Homo sapiens_hsa043400.93158452
29Lysine degradation_Homo sapiens_hsa003100.90994721
30Cocaine addiction_Homo sapiens_hsa050300.89432036
31Insulin resistance_Homo sapiens_hsa049310.89362022
32GnRH signaling pathway_Homo sapiens_hsa049120.89174233
33Osteoclast differentiation_Homo sapiens_hsa043800.86484987
34Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.84083404
35Long-term depression_Homo sapiens_hsa047300.81321632
36Steroid hormone biosynthesis_Homo sapiens_hsa001400.81194202
37Inositol phosphate metabolism_Homo sapiens_hsa005620.81026742
38Nitrogen metabolism_Homo sapiens_hsa009100.80842445
39Morphine addiction_Homo sapiens_hsa050320.80688029
40Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.79489909
41Circadian entrainment_Homo sapiens_hsa047130.79463616
42Retinol metabolism_Homo sapiens_hsa008300.79272947
43Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.78131824
44Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.77844938
45Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.77294802
46Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77127769
47Complement and coagulation cascades_Homo sapiens_hsa046100.76939866
48Arachidonic acid metabolism_Homo sapiens_hsa005900.76430302
49Chemokine signaling pathway_Homo sapiens_hsa040620.76134347
50ErbB signaling pathway_Homo sapiens_hsa040120.75304193
51Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.75294396
52Cholinergic synapse_Homo sapiens_hsa047250.73852957
53Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.72806203
54Chemical carcinogenesis_Homo sapiens_hsa052040.71911329
55cAMP signaling pathway_Homo sapiens_hsa040240.71048196
56MAPK signaling pathway_Homo sapiens_hsa040100.70997634
57Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70598950
58Ovarian steroidogenesis_Homo sapiens_hsa049130.69559794
59Dopaminergic synapse_Homo sapiens_hsa047280.69527688
60Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.68559011
61Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.68384427
62Salivary secretion_Homo sapiens_hsa049700.67660085
63Estrogen signaling pathway_Homo sapiens_hsa049150.67587505
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.67446425
65Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.66966778
66Neurotrophin signaling pathway_Homo sapiens_hsa047220.66609501
67Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.65504885
68Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.65425324
69Melanogenesis_Homo sapiens_hsa049160.65095799
70Bile secretion_Homo sapiens_hsa049760.64316060
71Acute myeloid leukemia_Homo sapiens_hsa052210.64296554
72T cell receptor signaling pathway_Homo sapiens_hsa046600.63192185
73Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.62923331
74NOD-like receptor signaling pathway_Homo sapiens_hsa046210.62682401
75Maturity onset diabetes of the young_Homo sapiens_hsa049500.62423087
76mTOR signaling pathway_Homo sapiens_hsa041500.62098770
77Taste transduction_Homo sapiens_hsa047420.61958609
78Nicotine addiction_Homo sapiens_hsa050330.61892924
79Serotonergic synapse_Homo sapiens_hsa047260.61077379
80Glutamatergic synapse_Homo sapiens_hsa047240.60853382
81Oxytocin signaling pathway_Homo sapiens_hsa049210.59424366
82Endometrial cancer_Homo sapiens_hsa052130.58728258
83Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.57871608
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.57784573
85Thyroid hormone synthesis_Homo sapiens_hsa049180.55810164
86Histidine metabolism_Homo sapiens_hsa003400.55798443
87Prolactin signaling pathway_Homo sapiens_hsa049170.55579311
88Lysosome_Homo sapiens_hsa041420.55351251
89Ras signaling pathway_Homo sapiens_hsa040140.55301052
90Rap1 signaling pathway_Homo sapiens_hsa040150.54656568
91Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.54248325
92Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.54047980
93Insulin signaling pathway_Homo sapiens_hsa049100.52557569
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.52136775
95Platelet activation_Homo sapiens_hsa046110.52064022
96Butanoate metabolism_Homo sapiens_hsa006500.50281370
97FoxO signaling pathway_Homo sapiens_hsa040680.49970021
98Gastric acid secretion_Homo sapiens_hsa049710.49775602
99Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.49572713
100Calcium signaling pathway_Homo sapiens_hsa040200.49025646

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »