CRISP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Fertilization consists of a sequence of specific cell-cell interactions culminating in the fusion of the sperm and egg plasma membranes. Recognition, binding, and fusion occur through the interaction of complementary molecules that are localized to specific domains of the sperm and egg plasma membranes. In the sperm, the postacrosomal region or equatorial segment is involved in sperm-egg plasma membrane fusion. The protein encoded by this gene is a member of the cysteine-rich secretory protein (CRISP) family. It is expressed in the epididymis, is secreted into the epididymal lumen, and binds to the postacrosomal region of the sperm head, where it plays a role in sperm-egg fusion. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of antigen processing and presentation (GO:0002579)9.46915201
2regulation of cell communication by electrical coupling (GO:0010649)8.85675343
3regulation of antigen processing and presentation (GO:0002577)7.65127775
4regulation of action potential (GO:0098900)7.52804550
5positive regulation of sodium ion transmembrane transporter activity (GO:2000651)7.52677085
6complement activation, alternative pathway (GO:0006957)6.51270646
7neuronal action potential (GO:0019228)6.50436405
8positive regulation of protein targeting to membrane (GO:0090314)6.20581837
9regulation of clathrin-mediated endocytosis (GO:2000369)6.00986696
10cytoskeletal anchoring at plasma membrane (GO:0007016)5.89474475
11response to parathyroid hormone (GO:0071107)5.63276904
12positive regulation of sodium ion transmembrane transport (GO:1902307)5.49151210
13piRNA metabolic process (GO:0034587)5.35605867
14regulation of homotypic cell-cell adhesion (GO:0034110)5.15871156
15histone H4-K12 acetylation (GO:0043983)4.93607905
16behavioral response to ethanol (GO:0048149)4.81032311
17hypotonic response (GO:0006971)4.72588538
18regulation of protein targeting to membrane (GO:0090313)4.71291076
19epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.68598083
20protein polyglutamylation (GO:0018095)4.62782209
21acrosome reaction (GO:0007340)4.58369623
22primary amino compound metabolic process (GO:1901160)4.54020573
23cellular ketone body metabolic process (GO:0046950)4.44998388
24DNA methylation involved in gamete generation (GO:0043046)4.37734294
25cyclooxygenase pathway (GO:0019371)4.34576362
26macroautophagy (GO:0016236)4.30752503
27sperm motility (GO:0030317)4.30302973
28serotonin metabolic process (GO:0042428)4.24326774
29sequestering of extracellular ligand from receptor (GO:0035581)4.21540209
30cellular sodium ion homeostasis (GO:0006883)4.15415637
31alpha-linolenic acid metabolic process (GO:0036109)4.14157775
32sulfur amino acid catabolic process (GO:0000098)4.13014808
33* fusion of sperm to egg plasma membrane (GO:0007342)4.06316019
34cytolysis (GO:0019835)3.94066823
35negative regulation of receptor-mediated endocytosis (GO:0048261)3.93790654
36cilium or flagellum-dependent cell motility (GO:0001539)3.92123345
37ketone body metabolic process (GO:1902224)3.91106176
38regulation of complement activation (GO:0030449)3.88738306
39multicellular organism reproduction (GO:0032504)3.86225544
40regulation of cilium movement (GO:0003352)3.83536155
41membrane assembly (GO:0071709)3.76933140
42regulation of protein activation cascade (GO:2000257)3.74109619
43heme transport (GO:0015886)3.71766450
44RNA destabilization (GO:0050779)3.69801680
45protein targeting to plasma membrane (GO:0072661)3.64250249
46photoreceptor cell differentiation (GO:0046530)3.61479216
47eye photoreceptor cell differentiation (GO:0001754)3.61479216
48reproduction (GO:0000003)3.59012920
49positive regulation of membrane potential (GO:0045838)3.58952136
50centriole replication (GO:0007099)3.55653120
51Golgi to plasma membrane protein transport (GO:0043001)3.53064101
52regulation of epithelial cell differentiation involved in kidney development (GO:2000696)3.50851820
53regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.46748832
54intra-Golgi vesicle-mediated transport (GO:0006891)3.46668625
55tonic smooth muscle contraction (GO:0014820)3.46386177
56epithelial cilium movement (GO:0003351)3.45311910
57pyrimidine ribonucleoside catabolic process (GO:0046133)3.44869403
58regulation of membrane depolarization (GO:0003254)3.42993137
59response to pheromone (GO:0019236)3.41991867
60action potential (GO:0001508)3.36794474
61galactose catabolic process (GO:0019388)3.36367919
62sexual reproduction (GO:0019953)3.35765332
63epithelial cell differentiation involved in kidney development (GO:0035850)3.34773806
64axonemal dynein complex assembly (GO:0070286)3.34050984
65negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.33560518
66indole-containing compound catabolic process (GO:0042436)3.30617746
67indolalkylamine catabolic process (GO:0046218)3.30617746
68tryptophan catabolic process (GO:0006569)3.30617746
69regulation of sodium ion transmembrane transporter activity (GO:2000649)3.30366646
70fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)3.25226286
71oxidative demethylation (GO:0070989)3.21987352
72NAD biosynthetic process (GO:0009435)3.21896075
73regulation of type B pancreatic cell apoptotic process (GO:2000674)3.20746562
74intestinal cholesterol absorption (GO:0030299)3.20487478
75indole-containing compound metabolic process (GO:0042430)3.19971167
76spermatid development (GO:0007286)3.18745496
77establishment of protein localization to Golgi (GO:0072600)3.12947896
78* plasma membrane fusion (GO:0045026)3.12906711
79motile cilium assembly (GO:0044458)3.11884854
80* cell-cell recognition (GO:0009988)3.07738813
81valine metabolic process (GO:0006573)3.07414874
82protein targeting to Golgi (GO:0000042)3.04445696
83* sperm-egg recognition (GO:0035036)3.03927423
84membrane depolarization during action potential (GO:0086010)3.01088202
85antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)21.4104690
86antigen processing and presentation of endogenous peptide antigen (GO:0002483)21.4104690
87antigen processing and presentation via MHC class Ib (GO:0002475)20.3047564
88regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.99660151
89reflex (GO:0060004)2.98676238
90positive regulation of sodium ion transport (GO:0010765)2.96242768
91regulation of establishment of cell polarity (GO:2000114)2.95583170
92negative regulation of activin receptor signaling pathway (GO:0032926)2.91273899
93carnitine metabolic process (GO:0009437)2.90797537
94spermatid nucleus differentiation (GO:0007289)2.89290683
95embryonic process involved in female pregnancy (GO:0060136)2.87239010
96prostaglandin metabolic process (GO:0006693)2.87006606
97prostanoid metabolic process (GO:0006692)2.87006606
98prostanoid biosynthetic process (GO:0046457)2.86336420
99prostaglandin biosynthetic process (GO:0001516)2.86336420
100regulation of microtubule-based movement (GO:0060632)2.85549422
101retrograde transport, vesicle recycling within Golgi (GO:0000301)2.84277494
102positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.82666552
103regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.82666552
104cell wall macromolecule catabolic process (GO:0016998)2.82157432
105centriole assembly (GO:0098534)2.81974355
106extracellular matrix assembly (GO:0085029)2.78657668
107linoleic acid metabolic process (GO:0043651)2.77252398
108microtubule severing (GO:0051013)2.76582268
109low-density lipoprotein particle clearance (GO:0034383)2.75730683
110sulfate transport (GO:0008272)2.75438743
111auditory receptor cell stereocilium organization (GO:0060088)2.72905749
112cilium movement (GO:0003341)2.72808959
113sodium ion homeostasis (GO:0055078)2.71606038
114male meiosis (GO:0007140)2.70947060
115triglyceride catabolic process (GO:0019433)2.70852916
116regulation of retinoic acid receptor signaling pathway (GO:0048385)2.70816297
117regulation of potassium ion transport (GO:0043266)2.65779039
118complement activation, classical pathway (GO:0006958)2.63540925
119ethanol oxidation (GO:0006069)2.62821285
120calcium ion-dependent exocytosis (GO:0017156)2.60324470
121neutral lipid catabolic process (GO:0046461)2.59374966
122acylglycerol catabolic process (GO:0046464)2.59374966
123positive regulation of Rab GTPase activity (GO:0032851)2.59147187
124regulation of Rab GTPase activity (GO:0032313)2.59147187
125regulation of Cdc42 GTPase activity (GO:0043088)2.58726021
126regulation of sodium ion transmembrane transport (GO:1902305)2.58522540
127microtubule polymerization or depolymerization (GO:0031109)2.57594116
128potassium ion import (GO:0010107)2.57265951
129iron coordination entity transport (GO:1901678)2.57264135
130tryptophan metabolic process (GO:0006568)2.57250455
131virion attachment to host cell (GO:0019062)2.56419335
132adhesion of symbiont to host cell (GO:0044650)2.56419335
133microtubule depolymerization (GO:0007019)2.55667863
134response to nitrosative stress (GO:0051409)2.55608785
135fibroblast migration (GO:0010761)2.55314226
136regulation of energy homeostasis (GO:2000505)2.54046686
137drug transmembrane transport (GO:0006855)2.52814727
138striated muscle atrophy (GO:0014891)2.51600064
139negative regulation of metanephros development (GO:0072217)2.51519420
140membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.51109788
141negative regulation of sterol transport (GO:0032372)2.50458855
142negative regulation of cholesterol transport (GO:0032375)2.50458855
143regulation of hydrogen peroxide metabolic process (GO:0010310)2.50263707
144protein K11-linked deubiquitination (GO:0035871)2.49813690
145Golgi to plasma membrane transport (GO:0006893)2.49703307
146parturition (GO:0007567)2.49166897
147regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.49134908
148cysteine metabolic process (GO:0006534)2.47697822
149phospholipid homeostasis (GO:0055091)2.44832651
150complement activation (GO:0006956)2.43689493
151transcytosis (GO:0045056)2.41970602
152GPI anchor biosynthetic process (GO:0006506)2.37346932
153GPI anchor metabolic process (GO:0006505)2.35683612
154regulation of hydrogen peroxide-induced cell death (GO:1903205)2.34272648
155negative regulation of lipase activity (GO:0060192)2.32496411
156mannose metabolic process (GO:0006013)2.31157001
157response to misfolded protein (GO:0051788)2.30998139
158negative regulation of protein autophosphorylation (GO:0031953)2.30071015
159metanephric nephron tubule development (GO:0072234)2.28677003
160metanephric tubule development (GO:0072170)2.28677003
161kynurenine metabolic process (GO:0070189)2.27001111
162brown fat cell differentiation (GO:0050873)2.26612692
163respiratory burst (GO:0045730)2.19972732
164homocysteine metabolic process (GO:0050667)2.19397561
165negative regulation of endopeptidase activity (GO:0010951)2.17879135
166cGMP-mediated signaling (GO:0019934)2.17109463
167long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)2.16514891
168relaxation of smooth muscle (GO:0044557)2.14824548
169positive regulation of fatty acid biosynthetic process (GO:0045723)2.13655923
170ovulation (GO:0030728)2.13198580
171regulation of humoral immune response (GO:0002920)2.11980348
172negative regulation of peptidase activity (GO:0010466)2.08694926
173fatty-acyl-CoA biosynthetic process (GO:0046949)2.07976033
174metanephric nephron epithelium development (GO:0072243)2.07719683
175nerve growth factor signaling pathway (GO:0038180)2.07431560
176regulation of lipoprotein metabolic process (GO:0050746)2.07079274
177organic cation transport (GO:0015695)2.05951216
178cellular response to osmotic stress (GO:0071470)2.05910687
179urate metabolic process (GO:0046415)2.05220665
180nucleoside diphosphate catabolic process (GO:0009134)2.04790614
181glycerolipid catabolic process (GO:0046503)2.03760427
182reverse cholesterol transport (GO:0043691)2.03386929
183establishment of nucleus localization (GO:0040023)2.03323557
184high-density lipoprotein particle remodeling (GO:0034375)2.03248293
185positive regulation of response to oxidative stress (GO:1902884)2.02855233
186positive regulation of cellular response to oxidative stress (GO:1900409)2.02855233
187response to folic acid (GO:0051593)2.02635761
188positive regulation of sterol transport (GO:0032373)2.01416491
189positive regulation of cholesterol transport (GO:0032376)2.01416491
190regulation of antigen processing and presentation of peptide antigen (GO:0002583)19.1090368
191antigen processing and presentation of endogenous antigen (GO:0019883)17.8431059
192positive regulation of action potential (GO:0045760)13.9855774
193triglyceride biosynthetic process (GO:0019432)1.99509319
194negative regulation of endocytosis (GO:0045806)1.97818470
195oxaloacetate metabolic process (GO:0006107)1.95270658
196collecting duct development (GO:0072044)1.94996022
197tricarboxylic acid metabolic process (GO:0072350)1.94472540
198negative regulation of platelet-derived growth factor receptor signaling pathway (GO:0010642)1.93822414

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.80930548
2GBX2_23144817_ChIP-Seq_PC3_Human3.90929566
3PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.90207593
4VDR_22108803_ChIP-Seq_LS180_Human3.64263384
5TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.46012005
6TRIM28_21343339_ChIP-Seq_HEK293_Human3.38324502
7GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.03695276
8GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.96344885
9ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.61873381
10AR_21572438_ChIP-Seq_LNCaP_Human2.40332788
11ESR1_21235772_ChIP-Seq_MCF-7_Human2.35975860
12IGF1R_20145208_ChIP-Seq_DFB_Human2.35137468
13CLOCK_20551151_ChIP-Seq_293T_Human2.22163651
14ESR2_21235772_ChIP-Seq_MCF-7_Human2.13745126
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.08803367
16PCGF2_27294783_Chip-Seq_NPCs_Mouse2.07644863
17LXR_22158963_ChIP-Seq_LIVER_Mouse2.05446141
18GATA1_22025678_ChIP-Seq_K562_Human13.2223253
19ZNF263_19887448_ChIP-Seq_K562_Human1.95299499
20ER_23166858_ChIP-Seq_MCF-7_Human1.93577444
21RXR_22158963_ChIP-Seq_LIVER_Mouse1.91837309
22CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91679624
23P300_19829295_ChIP-Seq_ESCs_Human1.90259848
24ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.82164054
25* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.78675031
26MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77919426
27PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.75028647
28NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.74195183
29HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.72629115
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.68526047
31POU3F2_20337985_ChIP-ChIP_501MEL_Human1.65530018
32TOP2B_26459242_ChIP-Seq_MCF-7_Human1.60705140
33ESR1_15608294_ChIP-ChIP_MCF-7_Human1.60502411
34FUS_26573619_Chip-Seq_HEK293_Human1.60353450
35TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.59153532
36SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58182744
37STAT3_23295773_ChIP-Seq_U87_Human1.53669030
38NR3C1_23031785_ChIP-Seq_PC12_Mouse1.50930773
39EP300_21415370_ChIP-Seq_HL-1_Mouse1.50699723
40TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.46104091
41EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.45732732
42PPARA_22158963_ChIP-Seq_LIVER_Mouse1.45138011
43ZNF274_21170338_ChIP-Seq_K562_Hela1.45037525
44* RUNX2_22187159_ChIP-Seq_PCA_Human1.44534251
45* TCF4_23295773_ChIP-Seq_U87_Human1.44005872
46SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.43694175
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.43556071
48CTBP2_25329375_ChIP-Seq_LNCAP_Human1.40611090
49TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38932978
50POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38932978
51BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.37229043
52CBP_20019798_ChIP-Seq_JUKART_Human1.37128190
53IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.37128190
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.34834706
55ZNF217_24962896_ChIP-Seq_MCF-7_Human1.31817009
56CBX2_27304074_Chip-Seq_ESCs_Mouse1.29549425
57AHR_22903824_ChIP-Seq_MCF-7_Human1.29414232
58SUZ12_27294783_Chip-Seq_NPCs_Mouse1.27774695
59TDRD3_21172665_ChIP-Seq_MCF-7_Human1.27526732
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.27026793
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.26770851
62AR_25329375_ChIP-Seq_VCAP_Human1.26577720
63PPAR_26484153_Chip-Seq_NCI-H1993_Human1.25443506
64SOX2_20726797_ChIP-Seq_SW620_Human1.24973227
65* PIAS1_25552417_ChIP-Seq_VCAP_Human1.21313376
66RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.21189672
67TP53_18474530_ChIP-ChIP_U2OS_Human1.21088470
68MYC_19915707_ChIP-ChIP_AK7_Human1.20466083
69EBNA1_20929547_Chip-Seq_RAJI-cells_Human1.20391227
70FOXO3_23340844_ChIP-Seq_DLD1_Human1.19789666
71AR_21915096_ChIP-Seq_LNCaP-1F5_Human1.18786530
72REST_21632747_ChIP-Seq_MESCs_Mouse1.17721144
73FOXA1_21572438_ChIP-Seq_LNCaP_Human1.16995263
74STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.16011447
75SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.14187130
76VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.13587902
77NFE2_27457419_Chip-Seq_LIVER_Mouse1.12966736
78RNF2_27304074_Chip-Seq_NSC_Mouse1.12801079
79SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12633894
80SMAD4_21741376_ChIP-Seq_EPCs_Human1.12502255
81RAC3_21632823_ChIP-Seq_H3396_Human1.11750240
82ARNT_22903824_ChIP-Seq_MCF-7_Human1.11271288
83FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.10951675
84ESR1_20079471_ChIP-ChIP_T-47D_Human1.10718795
85CTBP1_25329375_ChIP-Seq_LNCAP_Human1.10369365
86EGR1_23403033_ChIP-Seq_LIVER_Mouse1.09512142
87PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.09303194
88REST_18959480_ChIP-ChIP_MESCs_Mouse1.08940036
89TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.07344838
90PRDM14_20953172_ChIP-Seq_ESCs_Human1.06523678
91IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.06053100
92MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05465785
93BMI1_23680149_ChIP-Seq_NPCS_Mouse1.05293816
94AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.04881083
95FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.04223875
96KLF5_20875108_ChIP-Seq_MESCs_Mouse1.03810096
97PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03632420
98ERA_21632823_ChIP-Seq_H3396_Human1.03574906
99EZH2_27294783_Chip-Seq_NPCs_Mouse1.03375189
100FOXA2_19822575_ChIP-Seq_HepG2_Human1.02364606
101NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.02312767
102SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.01689365
103Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.01567981
104SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.01361773
105VDR_24787735_ChIP-Seq_THP-1_Human1.01003017
106SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.00181400
107TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.00050621
108LXR_22292898_ChIP-Seq_THP-1_Human0.99358419
109OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.99218199
110ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.98915847
111NANOG_20526341_ChIP-Seq_ESCs_Human0.98879606
112SMAD3_21741376_ChIP-Seq_EPCs_Human0.98729691
113SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.98336049
114EZH2_27304074_Chip-Seq_ESCs_Mouse0.97612518
115TAF15_26573619_Chip-Seq_HEK293_Human0.97037140
116NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.96772120
117RNF2_18974828_ChIP-Seq_MESCs_Mouse0.96713883
118EZH2_18974828_ChIP-Seq_MESCs_Mouse0.96713883
119CTNNB1_20460455_ChIP-Seq_HCT116_Human0.96667665
120SMAD4_21741376_ChIP-Seq_HESCs_Human0.96514383
121CEBPB_22108803_ChIP-Seq_LS180_Human0.96061329
122HOXB7_26014856_ChIP-Seq_BT474_Human0.95748117
123* GATA3_21878914_ChIP-Seq_MCF-7_Human0.95592884
124SOX2_21211035_ChIP-Seq_LN229_Gbm0.95070466
125SMAD4_21799915_ChIP-Seq_A2780_Human0.94972515
126FOXM1_26456572_ChIP-Seq_MCF-7_Human0.94641694
127TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse0.94510135
128BCAT_22108803_ChIP-Seq_LS180_Human0.93603513
129SOX2_19829295_ChIP-Seq_ESCs_Human0.92985787
130NANOG_19829295_ChIP-Seq_ESCs_Human0.92985787
131TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.92808427
132OCT4_20526341_ChIP-Seq_ESCs_Human0.92661167
133EZH2_27294783_Chip-Seq_ESCs_Mouse0.91979306
134ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.91900443
135TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.91641276
136RUNX_20019798_ChIP-Seq_JUKART_Human0.90807109
137TAL1_26923725_Chip-Seq_HPCs_Mouse0.90515251
138NANOG_18555785_Chip-Seq_ESCs_Mouse0.90244626
139SALL1_21062744_ChIP-ChIP_HESCs_Human0.89601130
140TP63_23658742_ChIP-Seq_EP156T_Human0.89119344
141ELK4_26923725_Chip-Seq_MESODERM_Mouse0.88869297
142SOX2_27498859_Chip-Seq_STOMACH_Mouse0.88828109
143TBX20_22080862_ChIP-Seq_HEART_Mouse0.86025935
144TBX20_22328084_ChIP-Seq_HEART_Mouse0.86025935
145SOX9_24532713_ChIP-Seq_HFSC_Mouse0.85613251
146GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.84101388
147DROSHA_22980978_ChIP-Seq_HELA_Human0.83767447
148EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.83317801
149DNAJC2_21179169_ChIP-ChIP_NT2_Human0.82719995
150SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.81587255
151WT1_19549856_ChIP-ChIP_CCG9911_Human0.81439507
152SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.81243846
153SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.80337199
154MTF2_20144788_ChIP-Seq_MESCs_Mouse0.79960150
155PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79894776
156RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.78192306
157RUNX1_27514584_Chip-Seq_MCF-7_Human0.74549858
158RARG_19884340_ChIP-ChIP_MEFs_Mouse0.73900029
159CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.73514058
160CSB_26484114_Chip-Seq_FIBROBLAST_Human0.73418386
161SALL4_18804426_ChIP-ChIP_XEN_Mouse0.73078854
162WT1_25993318_ChIP-Seq_PODOCYTE_Human0.73026846
163SMRT_27268052_Chip-Seq_Bcells_Human0.72893944
164GATA1_19941826_ChIP-Seq_K562_Human0.72042657
165GATA2_19941826_ChIP-Seq_K562_Human0.71655439
166* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.70660038
167CJUN_26792858_Chip-Seq_BT549_Human0.70093740
168OCT1_27270436_Chip-Seq_PROSTATE_Human0.69634963
169SMAD3_21741376_ChIP-Seq_HESCs_Human0.69354849
170PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.69210501
171CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.69043402
172WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.67247754
173TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.67141334
174SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.65858000
175EGR1_19032775_ChIP-ChIP_M12_Human0.65498496
176KDM2B_26808549_Chip-Seq_K562_Human0.65080664
177NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.64331329
178NRF2_20460467_ChIP-Seq_MEFs_Mouse0.64331329
179PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.63962608

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002102_abnormal_ear_morphology4.57189598
2MP0003283_abnormal_digestive_organ4.43622146
3MP0010386_abnormal_urinary_bladder4.05472582
4MP0008004_abnormal_stomach_pH3.94002677
5MP0005058_abnormal_lysosome_morphology3.60886817
6MP0002653_abnormal_ependyma_morphology3.40541588
7MP0008877_abnormal_DNA_methylation3.31866536
8MP0004147_increased_porphyrin_level3.19064139
9MP0003300_gastrointestinal_ulcer3.09986536
10MP0000569_abnormal_digit_pigmentation2.99345345
11MP0001873_stomach_inflammation2.88812937
12MP0008438_abnormal_cutaneous_collagen2.79568449
13MP0005275_abnormal_skin_tensile2.68608839
14MP0009379_abnormal_foot_pigmentation2.67903807
15MP0010234_abnormal_vibrissa_follicle2.63946614
16MP0008961_abnormal_basal_metabolism2.59892835
17MP0002139_abnormal_hepatobiliary_system2.59773280
18MP0003045_fibrosis2.55027892
19MP0003705_abnormal_hypodermis_morpholog2.51582952
20MP0005085_abnormal_gallbladder_physiolo2.46168218
21MP0005666_abnormal_adipose_tissue2.45584266
22MP0000015_abnormal_ear_pigmentation2.42920758
23MP0004133_heterotaxia2.42098056
24MP0002837_dystrophic_cardiac_calcinosis2.41250572
25MP0005646_abnormal_pituitary_gland2.17687201
26MP0005670_abnormal_white_adipose2.15352420
27MP0001756_abnormal_urination2.11874586
28MP0003303_peritoneal_inflammation2.09350869
29MP0005375_adipose_tissue_phenotype2.09125307
30MP0010352_gastrointestinal_tract_polyps1.97186809
31MP0005174_abnormal_tail_pigmentation1.94471003
32MP0001958_emphysema1.93830006
33MP0000462_abnormal_digestive_system1.93683815
34MP0005377_hearing/vestibular/ear_phenot1.88661416
35MP0003878_abnormal_ear_physiology1.88661416
36MP0004036_abnormal_muscle_relaxation1.85001452
37MP0010329_abnormal_lipoprotein_level1.84733729
38MP0002064_seizures1.79398975
39MP0004130_abnormal_muscle_cell1.78169940
40MP0001486_abnormal_startle_reflex1.77919980
41MP0000230_abnormal_systemic_arterial1.70247038
42MP0004185_abnormal_adipocyte_glucose1.63714255
43MP0000003_abnormal_adipose_tissue1.58806012
44MP0004858_abnormal_nervous_system1.57540132
45MP0009745_abnormal_behavioral_response1.56251950
46MP0002138_abnormal_hepatobiliary_system1.55300961
47* MP0003698_abnormal_male_reproductive1.54255748
48MP0005365_abnormal_bile_salt1.52027980
49MP0000538_abnormal_urinary_bladder1.49512497
50MP0001765_abnormal_ion_homeostasis1.49327707
51MP0002733_abnormal_thermal_nociception1.48672191
52MP0004019_abnormal_vitamin_homeostasis1.48420134
53MP0005379_endocrine/exocrine_gland_phen1.46882569
54MP0001664_abnormal_digestion1.46879498
55MP0000751_myopathy1.46655618
56MP0005360_urolithiasis1.46412897
57MP0002734_abnormal_mechanical_nocicepti1.46144237
58MP0001542_abnormal_bone_strength1.45880837
59MP0003195_calcinosis1.42230167
60MP0001970_abnormal_pain_threshold1.41696033
61MP0002166_altered_tumor_susceptibility1.41411658
62MP0001929_abnormal_gametogenesis1.40406070
63MP0003075_altered_response_to1.36754567
64MP0003191_abnormal_cellular_cholesterol1.35267764
65MP0005551_abnormal_eye_electrophysiolog1.34587665
66MP0004272_abnormal_basement_membrane1.32041276
67MP0002118_abnormal_lipid_homeostasis1.30079155
68MP0003866_abnormal_defecation1.29301919
69MP0009780_abnormal_chondrocyte_physiolo1.28853477
70MP0002876_abnormal_thyroid_physiology1.28566275
71MP0003011_delayed_dark_adaptation1.27652605
72MP0003252_abnormal_bile_duct1.27649117
73MP0005330_cardiomyopathy1.27153915
74MP0003137_abnormal_impulse_conducting1.26569432
75MP0002272_abnormal_nervous_system1.25939332
76MP0002928_abnormal_bile_duct1.25026198
77MP0003787_abnormal_imprinting1.22885408
78MP0000470_abnormal_stomach_morphology1.21437034
79MP0001968_abnormal_touch/_nociception1.21294909
80MP0009384_cardiac_valve_regurgitation1.20997980
81MP0002736_abnormal_nociception_after1.20848114
82MP0005620_abnormal_muscle_contractility1.20369009
83MP0005409_darkened_coat_color1.20241582
84MP0002168_other_aberrant_phenotype1.20074715
85MP0005164_abnormal_response_to1.17390325
86MP0002254_reproductive_system_inflammat1.16738028
87MP0003690_abnormal_glial_cell1.15371371
88MP0005636_abnormal_mineral_homeostasis1.13814654
89MP0003566_abnormal_cell_adhesion1.13531643
90MP0002295_abnormal_pulmonary_circulatio1.11791099
91MP0005410_abnormal_fertilization1.11277651
92MP0009053_abnormal_anal_canal1.11135096
93MP0009763_increased_sensitivity_to1.10739952
94MP0003943_abnormal_hepatobiliary_system1.08675120
95MP0009643_abnormal_urine_homeostasis1.07378786
96MP0005166_decreased_susceptibility_to1.06298258
97MP0005319_abnormal_enzyme/_coenzyme1.06277883
98MP0006276_abnormal_autonomic_nervous1.06049688
99MP0001177_atelectasis1.05820511
100MP0000750_abnormal_muscle_regeneration1.05639355
101MP0002572_abnormal_emotion/affect_behav1.05068269
102MP0001666_abnormal_nutrient_absorption1.03992447
103MP0005623_abnormal_meninges_morphology1.03769310
104MP0005332_abnormal_amino_acid1.03617042
105MP0000013_abnormal_adipose_tissue1.01268063
106MP0001533_abnormal_skeleton_physiology1.01131219
107MP0005595_abnormal_vascular_smooth0.99943922
108MP0005381_digestive/alimentary_phenotyp0.98711234
109MP0001348_abnormal_lacrimal_gland0.98215707
110MP0003879_abnormal_hair_cell0.93317158
111MP0002998_abnormal_bone_remodeling0.92642321
112MP0000537_abnormal_urethra_morphology0.92281748
113MP0003119_abnormal_digestive_system0.91946821
114MP0002234_abnormal_pharynx_morphology0.91195176
115MP0001919_abnormal_reproductive_system0.89974788
116MP0002006_tumorigenesis0.89803857
117MP0001764_abnormal_homeostasis0.89128147
118MP0004215_abnormal_myocardial_fiber0.88654968
119MP0002009_preneoplasia0.88218986
120MP0001485_abnormal_pinna_reflex0.86492732
121MP0005423_abnormal_somatic_nervous0.85670132
122MP0000609_abnormal_liver_physiology0.84438931
123MP0003646_muscle_fatigue0.83954852
124MP0003635_abnormal_synaptic_transmissio0.83108802
125MP0000026_abnormal_inner_ear0.82603822
126MP0010678_abnormal_skin_adnexa0.82543603
127MP0005389_reproductive_system_phenotype0.81964407
128MP0006138_congestive_heart_failure0.81427278
129MP0001188_hyperpigmentation0.81351548
130MP0005584_abnormal_enzyme/coenzyme_acti0.81152856
131MP0003638_abnormal_response/metabolism_0.78397788
132MP0005464_abnormal_platelet_physiology0.76541340
133MP0001293_anophthalmia0.76107510
134MP0004270_analgesia0.75797168
135MP0002136_abnormal_kidney_physiology0.75657083
136MP0002971_abnormal_brown_adipose0.75543621
137MP0004085_abnormal_heartbeat0.73676992
138MP0005334_abnormal_fat_pad0.73173456
139MP0001661_extended_life_span0.72954231
140MP0002796_impaired_skin_barrier0.72269903
141MP0002161_abnormal_fertility/fecundity0.72266100
142MP0002210_abnormal_sex_determination0.72243843
143MP0005253_abnormal_eye_physiology0.72007108
144MP0003436_decreased_susceptibility_to0.71957666
145MP0004885_abnormal_endolymph0.71663104
146MP0002229_neurodegeneration0.71629419
147MP0000678_abnormal_parathyroid_gland0.71446439
148MP0000383_abnormal_hair_follicle0.70145016
149MP0008569_lethality_at_weaning0.69646885
150MP0000566_synostosis0.69535843
151MP0001986_abnormal_taste_sensitivity0.69381206
152MP0002133_abnormal_respiratory_system0.69085617
153MP0005388_respiratory_system_phenotype0.69085617
154MP0003183_abnormal_peptide_metabolism0.68278386
155MP0008875_abnormal_xenobiotic_pharmacok0.68139508
156MP0001440_abnormal_grooming_behavior0.67060548
157MP0004145_abnormal_muscle_electrophysio0.66766856
158MP0004134_abnormal_chest_morphology0.66287832
159MP0002693_abnormal_pancreas_physiology0.65026097
160MP0001501_abnormal_sleep_pattern0.64578134
161MP0005084_abnormal_gallbladder_morpholo0.64368125
162MP0005395_other_phenotype0.63741915
163MP0004043_abnormal_pH_regulation0.63615881
164MP0000604_amyloidosis0.62796756
165MP0009115_abnormal_fat_cell0.62707558
166MP0001545_abnormal_hematopoietic_system0.61091989
167MP0005397_hematopoietic_system_phenotyp0.61091989
168MP0000778_abnormal_nervous_system0.60730124
169MP0002063_abnormal_learning/memory/cond0.59649507
170MP0001145_abnormal_male_reproductive0.59257771
171MP0009046_muscle_twitch0.59160955

Predicted human phenotypes

RankGene SetZ-score
1Facial diplegia (HP:0001349)8.84505049
2Increased density of long bones (HP:0006392)7.78641261
3Aortic aneurysm (HP:0004942)7.12779360
4Complement deficiency (HP:0004431)6.90298397
5Absent/shortened dynein arms (HP:0200106)5.93834316
6Dynein arm defect of respiratory motile cilia (HP:0012255)5.93834316
7Aortic dissection (HP:0002647)5.40975110
8Elevated circulating parathyroid hormone (PTH) level (HP:0003165)5.16889076
9Recurrent gram-negative bacterial infections (HP:0005420)4.98665325
10Abnormality of complement system (HP:0005339)4.97104257
11Enlarged epiphyses (HP:0010580)4.65654320
12Hypoplastic ischia (HP:0003175)4.32908889
13Azoospermia (HP:0000027)4.15550198
14Pancreatic cysts (HP:0001737)4.12674616
15Broad ribs (HP:0000885)3.88996008
16Overgrowth (HP:0001548)3.85873726
17Abnormal ciliary motility (HP:0012262)3.78985784
18Attenuation of retinal blood vessels (HP:0007843)3.78985637
19Chronic hepatic failure (HP:0100626)3.71960022
20Abnormality of the ischium (HP:0003174)3.66078611
21Central scotoma (HP:0000603)3.65516944
22Nephronophthisis (HP:0000090)3.52454980
23Abnormal respiratory motile cilium morphology (HP:0005938)3.47028101
24Abnormal respiratory epithelium morphology (HP:0012253)3.47028101
25Choanal stenosis (HP:0000452)3.42727261
26Progressive visual loss (HP:0000529)3.41348091
27Aplasia/Hypoplasia of the pubic bone (HP:0009104)3.29028413
28Ileus (HP:0002595)3.26537023
29Large for gestational age (HP:0001520)3.25010967
30Abnormality of the calcaneus (HP:0008364)3.24146849
31Abnormal respiratory motile cilium physiology (HP:0012261)3.22738412
32Molar tooth sign on MRI (HP:0002419)3.20964224
33Abnormality of midbrain morphology (HP:0002418)3.20964224
34Facial shape deformation (HP:0011334)3.19733440
35Potter facies (HP:0002009)3.19733440
36Abnormality of macular pigmentation (HP:0008002)3.19300335
37Congenital sensorineural hearing impairment (HP:0008527)3.13918363
38Abnormality of the axillary hair (HP:0100134)3.11151608
39Abnormality of secondary sexual hair (HP:0009888)3.11151608
40Abnormal spermatogenesis (HP:0008669)3.10667094
41Choroideremia (HP:0001139)3.10397233
42Flattened epiphyses (HP:0003071)3.10298170
43Sudden death (HP:0001699)3.08053670
44Irregular vertebral endplates (HP:0003301)2.97418023
45Abnormal biliary tract physiology (HP:0012439)2.96264223
46Bile duct proliferation (HP:0001408)2.96264223
47Cone-rod dystrophy (HP:0000548)2.89057661
48Abnormality of the renal medulla (HP:0100957)2.87722319
49Abnormality of the epiphysis of the femoral head (HP:0010574)2.83502322
50Abnormal cortical bone morphology (HP:0003103)2.76187312
51Aneurysm (HP:0002617)2.76074525
52Infertility (HP:0000789)2.74994548
53Pancreatic fibrosis (HP:0100732)2.73016294
5411 pairs of ribs (HP:0000878)2.71871284
55Abnormality of calcium-phosphate metabolism (HP:0100530)2.68847706
56Action tremor (HP:0002345)2.68151726
57Pendular nystagmus (HP:0012043)2.67560406
58Vascular calcification (HP:0004934)2.67115190
59Proximal tubulopathy (HP:0000114)2.66346054
60Vacuolated lymphocytes (HP:0001922)2.65504483
61Cardiovascular calcification (HP:0011915)2.65456488
62Abnormality of the femoral head (HP:0003368)2.62718945
63Dyschromatopsia (HP:0007641)2.62467332
64Malnutrition (HP:0004395)2.62002451
65Abnormality involving the epiphyses of the lower limbs (HP:0006500)2.58677166
66Abnormality of femoral epiphyses (HP:0006499)2.58677166
67Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.57934769
68Growth hormone excess (HP:0000845)2.56652640
69Osteolytic defects of the hand bones (HP:0009699)2.56377063
70Osteolytic defects of the phalanges of the hand (HP:0009771)2.56377063
71Tented upper lip vermilion (HP:0010804)2.56079021
72Myocardial infarction (HP:0001658)2.55931088
73Cystic liver disease (HP:0006706)2.54858443
74True hermaphroditism (HP:0010459)2.54479912
75Aortic regurgitation (HP:0001659)2.53385387
76Neoplasm of the heart (HP:0100544)2.53325110
77Thyroid-stimulating hormone excess (HP:0002925)2.52532073
78Broad metatarsal (HP:0001783)2.50177338
79Stridor (HP:0010307)2.49969785
80Metaphyseal cupping (HP:0003021)2.49131266
81Atonic seizures (HP:0010819)2.48536956
82Intention tremor (HP:0002080)2.47149172
83Abnormality of the fovea (HP:0000493)2.45031507
84Inability to walk (HP:0002540)2.44644130
85Febrile seizures (HP:0002373)2.38151599
86Abnormal drinking behavior (HP:0030082)2.37530791
87Polydipsia (HP:0001959)2.37530791
88Protruding tongue (HP:0010808)2.36552800
89Abnormality of the pubic bones (HP:0003172)2.36467154
90Stroke (HP:0001297)2.36056427
91Facial hemangioma (HP:0000329)2.35534667
92Tubulointerstitial fibrosis (HP:0005576)2.34036797
93Aplasia/Hypoplasia of the tibia (HP:0005772)2.33385587
94Ventricular fibrillation (HP:0001663)2.25332795
95Progressive inability to walk (HP:0002505)2.24676412
96Congenital, generalized hypertrichosis (HP:0004540)2.23464229
97Type 1 muscle fiber predominance (HP:0003803)2.22903882
98Abnormality of the vertebral endplates (HP:0005106)2.18742262
99Furrowed tongue (HP:0000221)2.18737457
100Increased corneal curvature (HP:0100692)2.18074937
101Keratoconus (HP:0000563)2.18074937
102Duplicated collecting system (HP:0000081)2.18015500
103Bulbous nose (HP:0000414)2.16834025
104Abnormality of transition element cation homeostasis (HP:0011030)2.15354713
105Hand muscle atrophy (HP:0009130)2.14084057
106Abnormal rod and cone electroretinograms (HP:0008323)2.10864021
107Myopathic facies (HP:0002058)2.10498071
108Curly hair (HP:0002212)2.10446242
109Ankle contracture (HP:0006466)2.07583729
110Congenital hepatic fibrosis (HP:0002612)2.04485304
111Hypopigmentation of the fundus (HP:0007894)2.01450619
112Hyporeflexia of lower limbs (HP:0002600)2.01035583
113Gastrointestinal dysmotility (HP:0002579)2.00531112
114Papilledema (HP:0001085)14.6972227
115Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.99566077
116Abolished electroretinogram (ERG) (HP:0000550)1.99341673
117Stomach cancer (HP:0012126)1.98715526
118Missing ribs (HP:0000921)1.98705527
119Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.97555324
120Degeneration of the lateral corticospinal tracts (HP:0002314)1.97555324
121Bony spicule pigmentary retinopathy (HP:0007737)1.97084393
122Mixed hearing impairment (HP:0000410)1.96330398
123Severe visual impairment (HP:0001141)1.95565747
124Distal upper limb amyotrophy (HP:0007149)1.95233427
125Upper limb amyotrophy (HP:0009129)1.95233427
126Abnormality of the sella turcica (HP:0002679)1.93863013
127Renal Fanconi syndrome (HP:0001994)1.93772058
128Tubulointerstitial nephritis (HP:0001970)1.93036074
129Progressive cerebellar ataxia (HP:0002073)1.91873445
130Scotoma (HP:0000575)1.91330440
131Amelogenesis imperfecta (HP:0000705)1.91015494
132Craniofacial hyperostosis (HP:0004493)1.90638070
133Abnormality of renal resorption (HP:0011038)1.90086268
134Bicornuate uterus (HP:0000813)1.88347863
135Hypophosphatemic rickets (HP:0004912)1.88256768
136Constricted visual fields (HP:0001133)1.88126066
137Systemic lupus erythematosus (HP:0002725)1.87639994
138Infantile muscular hypotonia (HP:0008947)1.86298122
139Aggressive behavior (HP:0000718)1.85612913
140Hyperglycinuria (HP:0003108)1.84676628
141Bicuspid aortic valve (HP:0001647)1.84493479
142Increased connective tissue (HP:0009025)1.84437405
143Hypoplasia of the iris (HP:0007676)1.83645267
144Focal segmental glomerulosclerosis (HP:0000097)1.82153201
145Maternal diabetes (HP:0009800)1.81978606
146Neurodegeneration (HP:0002180)1.81941877
147Abnormality of the renal cortex (HP:0011035)1.81919303
148Tubular atrophy (HP:0000092)1.80222081
149Arthropathy (HP:0003040)1.80058321
150Postural instability (HP:0002172)1.79437660
151Ketoacidosis (HP:0001993)1.79026367
152Cerebral aneurysm (HP:0004944)1.77872701
153Elevated alkaline phosphatase (HP:0003155)1.77673015
154Hypothermia (HP:0002045)1.77632927
155Muscle fiber splitting (HP:0003555)1.76734280
156Primary atrial arrhythmia (HP:0001692)1.76516082
157Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.76269428
158Absent epiphyses (HP:0010577)1.76269428
159Skin nodule (HP:0200036)1.73740231
160Absent rod-and cone-mediated responses on ERG (HP:0007688)1.73625328
161Poikilocytosis (HP:0004447)1.73574236
162Abnormality of the renal collecting system (HP:0004742)1.73054376
163Truncal obesity (HP:0001956)1.72931480
164Poor eye contact (HP:0000817)1.72679891
165Thin bony cortex (HP:0002753)1.72241280
166Long foot (HP:0001833)1.71389646
167Acanthosis nigricans (HP:0000956)1.71332474
168Hypercholesterolemia (HP:0003124)1.69505828
169Sclerocornea (HP:0000647)1.69182581
170Polar cataract (HP:0010696)1.68486885
171Concave nail (HP:0001598)1.67865450
172Abnormal enzyme/coenzyme activity (HP:0012379)1.64560382
173Scapular winging (HP:0003691)1.64131033
174Macular degeneration (HP:0000608)1.63866307
175Subcapsular cataract (HP:0000523)1.61939830
176Cerebral palsy (HP:0100021)1.61321532
177Decreased central vision (HP:0007663)1.61262206
178Deep venous thrombosis (HP:0002625)1.60913981
179Abnormality of alkaline phosphatase activity (HP:0004379)1.60825579
180Ulnar bowing (HP:0003031)1.60647249
181Dysostosis multiplex (HP:0000943)1.60439586
182Hemiplegia (HP:0002301)1.56700714
183Testicular atrophy (HP:0000029)1.55627173
184Oligomenorrhea (HP:0000876)1.54650611
185Ulnar deviation of the wrist (HP:0003049)1.53642260
186Aplasia involving bones of the extremities (HP:0009825)1.52362655
187Aplasia involving bones of the upper limbs (HP:0009823)1.52362655
188Aplasia of the phalanges of the hand (HP:0009802)1.52362655
189Osteomalacia (HP:0002749)1.51862780

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MYLK9.34253108
2SIK26.45732033
3MAP4K24.85498235
4TTN4.18885827
5NTRK34.00672103
6PASK3.65910220
7DMPK3.31772032
8PIK3CG3.22672997
9ZAK3.17511740
10AKT33.15282461
11PAK23.03194750
12FRK2.84111695
13BRD42.56259647
14PLK42.26497323
15LMTK22.21605442
16PINK12.15578345
17PNCK2.11733995
18INSRR2.10913699
19TAOK32.08781106
20BMPR1B2.05383015
21ACVR1B1.95167454
22TRIB31.91728498
23SIK11.77068006
24DDR21.69944844
25CAMK1D1.66692052
26RIPK11.65984163
27ADRBK21.53822901
28FGFR21.53095714
29BRSK21.40933990
30TESK11.40377936
31TGFBR11.40249045
32CDC42BPA1.29263270
33MST41.26884698
34LATS11.26302065
35PDGFRA1.22603521
36DAPK31.21239618
37FER1.16654668
38CAMK1G1.15670487
39MAP2K31.12851076
40NUAK11.04505831
41WNK41.04121343
42EEF2K1.04017303
43MAP3K31.03862942
44ERN11.03594307
45PRKCQ1.00237327
46PKN20.96912543
47SGK20.92691242
48CAMK2G0.91925811
49PAK30.87849672
50MAP3K20.86216000
51ADRBK10.85280240
52ROCK10.85157430
53WEE10.84624558
54TNIK0.82638403
55GSK3A0.82064636
56MATK0.81605912
57TRPM70.78816679
58CDK80.78579211
59STK160.78436565
60GRK10.78259598
61LRRK20.78232083
62SCYL20.77313750
63GRK60.76964768
64FYN0.72760565
65EPHB10.72485881
66PAK10.71611908
67BCKDK0.69855529
68PLK20.69536392
69MAP3K60.69465302
70MAPK40.69440460
71HCK0.68906610
72SGK4940.68565812
73SGK2230.68565812
74PHKG10.68295931
75PHKG20.68295931
76RPS6KA50.68044336
77PIK3CA0.67928021
78SYK0.66937203
79MAP3K90.66177150
80MAP2K40.65340176
81ILK0.63772076
82TEC0.63766054
83TLK10.63189922
84MAP2K60.62033299
85PTK20.61067719
86MAPK130.60599168
87MAPK150.60348231
88ERBB20.60189051
89ITK0.59751480
90BMX0.59693670
91RET0.59606638
92IRAK30.58300172
93JAK10.57546356
94MAP3K110.57211772
95PRKCH0.56606241
96DYRK1B0.56279855
97PRKD30.55199236
98WNK10.54926754
99DAPK20.54820837
100PRKG20.54478060
101JAK20.54365461
102CHUK0.54242660
103FGFR40.53331802
104MAPK110.51966803
105RIPK40.51764455
106EGFR0.51432718
107RAF10.50966052
108TIE10.50216731
109CAMK10.48416702
110NTRK10.48389586
111MAP2K20.48325987
112PRKAA20.47737120
113TGFBR20.45317458
114NEK20.44570592
115PTK60.43466446
116MAP3K40.43417699
117RPS6KA60.41981188
118PIM10.40791386
119LATS20.39487353
120MAP2K10.38829050
121PRKG10.38236040
122PRKACB0.38210169
123SRC0.37339401
124MST1R0.36774700
125PRKCZ0.36165430
126BTK0.35969112
127IRAK20.35591758
128CAMKK20.34993997
129WNK30.34257698
130ROCK20.33869576
131CDK70.33042695
132PDGFRB0.32988459
133INSR0.32279080
134GRK70.31707819
135PDPK10.31397797
136PTK2B0.30962593
137PRKCG0.30708516
138MET0.30704338
139PDK40.29579056
140PDK30.29579056
141TYRO30.29404132
142PDK10.28683081
143CSF1R0.28372056
144NEK60.28253010
145MAPKAPK50.27988459
146CSK0.27177517
147PLK10.27053817
148MAPKAPK30.27030198
149PRKACA0.26817264
150IKBKB0.26400875
151RPS6KA10.25839300
152MUSK0.24916273
153PDK20.24859681
154MTOR0.24772634
155SGK30.24485435
156PRKAA10.24368807
157MAPKAPK20.24222662
158SGK10.24063177
159EPHB20.23868354
160PRKACG0.23632609
161BMPR20.23305409
162ICK0.23168452
163IGF1R0.23124648
164JAK30.22533471
165FGFR30.22113546
166PRKCE0.21960874
167PRKCA0.21189091
168RPS6KA20.20527709
169STK100.19727038
170STK390.19318666

Predicted pathways (KEGG)

RankGene SetZ-score
1ABC transporters_Homo sapiens_hsa020104.57058701
2Nitrogen metabolism_Homo sapiens_hsa009103.75355519
3Asthma_Homo sapiens_hsa053103.54700755
4Allograft rejection_Homo sapiens_hsa053303.22147765
5Graft-versus-host disease_Homo sapiens_hsa053323.19814826
6Autoimmune thyroid disease_Homo sapiens_hsa053203.10561352
7Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.07731299
8Intestinal immune network for IgA production_Homo sapiens_hsa046722.92812656
9Type I diabetes mellitus_Homo sapiens_hsa049402.72521838
10Fatty acid degradation_Homo sapiens_hsa000712.56870350
11PPAR signaling pathway_Homo sapiens_hsa033202.52330982
12Fatty acid metabolism_Homo sapiens_hsa012122.49750361
13Taste transduction_Homo sapiens_hsa047422.34926962
14Sulfur metabolism_Homo sapiens_hsa009202.33828199
15Regulation of lipolysis in adipocytes_Homo sapiens_hsa049232.31599643
16Linoleic acid metabolism_Homo sapiens_hsa005912.23810799
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.21246377
18Fatty acid biosynthesis_Homo sapiens_hsa000612.19771608
19Complement and coagulation cascades_Homo sapiens_hsa046102.07912062
20Prion diseases_Homo sapiens_hsa050202.05181421
21Vascular smooth muscle contraction_Homo sapiens_hsa042701.83629050
22Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.80548859
23Primary bile acid biosynthesis_Homo sapiens_hsa001201.74770489
24Nicotine addiction_Homo sapiens_hsa050331.73907917
25Viral myocarditis_Homo sapiens_hsa054161.70367663
26Olfactory transduction_Homo sapiens_hsa047401.69808691
27Glycerolipid metabolism_Homo sapiens_hsa005611.66354229
28Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61174225
29Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.59024737
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.59000420
31Arginine biosynthesis_Homo sapiens_hsa002201.56812437
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.47050243
33Phototransduction_Homo sapiens_hsa047441.42996630
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.42210445
35alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.38470292
36Staphylococcus aureus infection_Homo sapiens_hsa051501.37549084
37Antigen processing and presentation_Homo sapiens_hsa046121.37481045
382-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.36905916
39ECM-receptor interaction_Homo sapiens_hsa045121.36876780
40Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.32855768
41Arachidonic acid metabolism_Homo sapiens_hsa005901.31049151
42Tyrosine metabolism_Homo sapiens_hsa003501.30045254
43Bile secretion_Homo sapiens_hsa049761.29843951
44Protein digestion and absorption_Homo sapiens_hsa049741.28183198
45Salivary secretion_Homo sapiens_hsa049701.26706593
46Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.23519828
47Other glycan degradation_Homo sapiens_hsa005111.21672222
48Propanoate metabolism_Homo sapiens_hsa006401.21560939
49Gastric acid secretion_Homo sapiens_hsa049711.18563818
50Tryptophan metabolism_Homo sapiens_hsa003801.18443030
51Focal adhesion_Homo sapiens_hsa045101.18059254
52Circadian entrainment_Homo sapiens_hsa047131.17893393
53Fat digestion and absorption_Homo sapiens_hsa049751.10809017
54Thyroid hormone synthesis_Homo sapiens_hsa049181.10176639
55Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.08525084
56Chemical carcinogenesis_Homo sapiens_hsa052041.06787478
57Serotonergic synapse_Homo sapiens_hsa047261.06593387
58Morphine addiction_Homo sapiens_hsa050321.05800938
59Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03022179
60Steroid hormone biosynthesis_Homo sapiens_hsa001401.01166538
61Carbon metabolism_Homo sapiens_hsa012000.97346868
62Leishmaniasis_Homo sapiens_hsa051400.94119428
63Phenylalanine metabolism_Homo sapiens_hsa003600.93914200
64Maturity onset diabetes of the young_Homo sapiens_hsa049500.93716480
65Long-term depression_Homo sapiens_hsa047300.93407132
66Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.93209173
67Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.92948338
68Platelet activation_Homo sapiens_hsa046110.92330573
69Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.92239720
70Biosynthesis of amino acids_Homo sapiens_hsa012300.91287341
71Vitamin digestion and absorption_Homo sapiens_hsa049770.90039678
72cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88488585
73Adipocytokine signaling pathway_Homo sapiens_hsa049200.88461609
74Glutamatergic synapse_Homo sapiens_hsa047240.86714415
75Ether lipid metabolism_Homo sapiens_hsa005650.86445451
76Renin secretion_Homo sapiens_hsa049240.84123842
77Pyruvate metabolism_Homo sapiens_hsa006200.83790808
78Butanoate metabolism_Homo sapiens_hsa006500.83416581
79Peroxisome_Homo sapiens_hsa041460.83301163
80Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.79327499
81Retinol metabolism_Homo sapiens_hsa008300.76145275
82Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75728967
83beta-Alanine metabolism_Homo sapiens_hsa004100.75038328
84Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.74909421
85Rheumatoid arthritis_Homo sapiens_hsa053230.74454115
86Vitamin B6 metabolism_Homo sapiens_hsa007500.73497628
87Lysosome_Homo sapiens_hsa041420.73470628
88Systemic lupus erythematosus_Homo sapiens_hsa053220.71093316
89Starch and sucrose metabolism_Homo sapiens_hsa005000.70974366
90Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.68417797
91Oxytocin signaling pathway_Homo sapiens_hsa049210.66184987
92Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.65995261
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.65910339
94Histidine metabolism_Homo sapiens_hsa003400.63420109
95Type II diabetes mellitus_Homo sapiens_hsa049300.61102875
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.60739176
97Insulin resistance_Homo sapiens_hsa049310.58067628
98Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.56944835
99Glycerophospholipid metabolism_Homo sapiens_hsa005640.56470401
100Tight junction_Homo sapiens_hsa045300.55680742
101Mineral absorption_Homo sapiens_hsa049780.54890422
102Calcium signaling pathway_Homo sapiens_hsa040200.52907336
103Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.52262991
104Amoebiasis_Homo sapiens_hsa051460.51533469
105Glutathione metabolism_Homo sapiens_hsa004800.50295796
106GABAergic synapse_Homo sapiens_hsa047270.49042626
107Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48761633
108Dilated cardiomyopathy_Homo sapiens_hsa054140.47956343
109AMPK signaling pathway_Homo sapiens_hsa041520.46557236
110Ovarian steroidogenesis_Homo sapiens_hsa049130.46114367
111Proteoglycans in cancer_Homo sapiens_hsa052050.43859732
112SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43849735
113cAMP signaling pathway_Homo sapiens_hsa040240.42910664
114Cocaine addiction_Homo sapiens_hsa050300.40617141
115Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.39618802
116Estrogen signaling pathway_Homo sapiens_hsa049150.38248954
117Leukocyte transendothelial migration_Homo sapiens_hsa046700.36555751
118Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35993031
119Pancreatic secretion_Homo sapiens_hsa049720.35471895
120Caffeine metabolism_Homo sapiens_hsa002320.34688283
121Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.34679196
122Hematopoietic cell lineage_Homo sapiens_hsa046400.33820820
123Carbohydrate digestion and absorption_Homo sapiens_hsa049730.32808190
124Glucagon signaling pathway_Homo sapiens_hsa049220.32576266
125Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32134491
126Dorso-ventral axis formation_Homo sapiens_hsa043200.29862940
127African trypanosomiasis_Homo sapiens_hsa051430.29512360
128Cholinergic synapse_Homo sapiens_hsa047250.28950977
129Arginine and proline metabolism_Homo sapiens_hsa003300.27879690
130Toxoplasmosis_Homo sapiens_hsa051450.27285045
131Sphingolipid metabolism_Homo sapiens_hsa006000.27235275
132Pentose phosphate pathway_Homo sapiens_hsa000300.26012147
133Influenza A_Homo sapiens_hsa051640.25782419
134Transcriptional misregulation in cancer_Homo sapiens_hsa052020.25505886
135Cysteine and methionine metabolism_Homo sapiens_hsa002700.24487539
136Circadian rhythm_Homo sapiens_hsa047100.24341218
137Aldosterone synthesis and secretion_Homo sapiens_hsa049250.24270420
138Insulin signaling pathway_Homo sapiens_hsa049100.24164408
139Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.24045380
140Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.23021271
141Adherens junction_Homo sapiens_hsa045200.22759407
142MAPK signaling pathway_Homo sapiens_hsa040100.22479740
143Herpes simplex infection_Homo sapiens_hsa051680.22396763
144Selenocompound metabolism_Homo sapiens_hsa004500.22195264
145Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.22161548
146Regulation of actin cytoskeleton_Homo sapiens_hsa048100.21924215
147Insulin secretion_Homo sapiens_hsa049110.21728639
148Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.20716916
149Regulation of autophagy_Homo sapiens_hsa041400.19616429
150Hedgehog signaling pathway_Homo sapiens_hsa043400.19301583

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »