CRISP3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the cysteine-rich secretory protein (CRISP) family within the CRISP, antigen 5 and pathogenesis-related 1 proteins superfamily. The encoded protein has an N-terminal CRISP, antigen 5 and pathogenesis-related 1 proteins domain, a hinge region, and a C-terminal ion channel regulator domain. This protein contains cysteine residues, located in both the N- and C-terminal domains, that form eight disulfide bonds, a distinguishing characteristic of this family. This gene is expressed in the male reproductive tract where it plays a role in sperm function and fertilization, and the female reproductive tract where it plays a role in endometrial receptivity for embryo implantation. This gene is upregulated in certain types of prostate cancer. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antibacterial humoral response (GO:0019731)9.86252164
2innate immune response in mucosa (GO:0002227)9.71732185
3antimicrobial humoral response (GO:0019730)9.66398144
4regulation of T cell tolerance induction (GO:0002664)9.04148947
5defense response to fungus (GO:0050832)8.56701391
6pyrimidine ribonucleoside catabolic process (GO:0046133)8.41772016
7mucosal immune response (GO:0002385)7.91883272
8B cell receptor signaling pathway (GO:0050853)7.90729402
9organ or tissue specific immune response (GO:0002251)7.34504967
10antigen processing and presentation of endogenous antigen (GO:0019883)7.21000978
11production of molecular mediator involved in inflammatory response (GO:0002532)7.12317289
12intestinal epithelial cell development (GO:0060576)7.05420389
13negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)6.96234629
14cellular response to zinc ion (GO:0071294)6.90248471
15disruption of cells of other organism (GO:0044364)6.88740822
16killing of cells of other organism (GO:0031640)6.88740822
17positive regulation of tolerance induction (GO:0002645)6.67477653
18regulation of tolerance induction (GO:0002643)6.66089649
19somatic hypermutation of immunoglobulin genes (GO:0016446)6.59989631
20somatic diversification of immune receptors via somatic mutation (GO:0002566)6.59989631
21regulation of B cell receptor signaling pathway (GO:0050855)6.17694814
22positive regulation of type 2 immune response (GO:0002830)6.06234711
23response to fungus (GO:0009620)6.04819266
24iron ion import (GO:0097286)5.71919681
25response to peptidoglycan (GO:0032494)5.65792820
26branching involved in prostate gland morphogenesis (GO:0060442)5.55539467
27interferon-gamma secretion (GO:0072643)5.38796165
28chaperone mediated protein folding requiring cofactor (GO:0051085)5.35928076
29killing of cells in other organism involved in symbiotic interaction (GO:0051883)5.26548081
30disruption of cells of other organism involved in symbiotic interaction (GO:0051818)5.26548081
31positive regulation of steroid hormone secretion (GO:2000833)5.12612853
32positive thymic T cell selection (GO:0045059)4.91645799
33positive regulation of transcription from RNA polymerase III promoter (GO:0045945)4.88819902
34detection of other organism (GO:0098543)4.87767613
35negative regulation of B cell apoptotic process (GO:0002903)4.83752722
36detection of bacterium (GO:0016045)4.73478270
37mature B cell differentiation (GO:0002335)4.56021785
38negative regulation of bone mineralization (GO:0030502)4.55105648
39response to host immune response (GO:0052572)4.52701140
40response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.52701140
41regulation of chronic inflammatory response (GO:0002676)4.47698149
42hypotonic response (GO:0006971)4.41616869
43kynurenine metabolic process (GO:0070189)4.41097333
44regulation of B cell apoptotic process (GO:0002902)4.37399284
45peptide cross-linking (GO:0018149)4.37313525
46leukocyte migration involved in inflammatory response (GO:0002523)4.32620483
47B cell proliferation (GO:0042100)4.18967932
48keratinization (GO:0031424)4.17515139
49regulation of B cell proliferation (GO:0030888)4.14927609
50positive regulation of gamma-delta T cell activation (GO:0046645)4.11080429
51tryptophan catabolic process (GO:0006569)4.10924475
52indole-containing compound catabolic process (GO:0042436)4.10924475
53indolalkylamine catabolic process (GO:0046218)4.10924475
54negative regulation of interleukin-8 production (GO:0032717)4.09939483
55defense response to Gram-positive bacterium (GO:0050830)4.06648981
56response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.05679508
57response to host (GO:0075136)4.05679508
58response to host defenses (GO:0052200)4.05679508
59cellular extravasation (GO:0045123)4.05160951
60positive regulation of osteoblast proliferation (GO:0033690)4.03819032
61negative regulation of biomineral tissue development (GO:0070168)3.99917612
62regulation of dendritic cell antigen processing and presentation (GO:0002604)3.97629270
63negative regulation of B cell proliferation (GO:0030889)3.97207724
64regulation of superoxide anion generation (GO:0032928)3.93957087
65negative regulation of gene silencing (GO:0060969)3.92890107
66negative regulation of interleukin-10 production (GO:0032693)3.92343113
67regulation of B cell differentiation (GO:0045577)3.91499613
68negative thymic T cell selection (GO:0045060)3.87221350
69negative regulation of execution phase of apoptosis (GO:1900118)3.86545438
70regulation of germinal center formation (GO:0002634)3.82727499
71antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.82643848
72antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.82643848
73regulation of antigen receptor-mediated signaling pathway (GO:0050854)3.77999035
74negative regulation of lymphocyte apoptotic process (GO:0070229)3.76796676
75purine nucleotide transport (GO:0015865)3.70645478
76prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis (GO:0060523.70200490
77mature B cell differentiation involved in immune response (GO:0002313)3.67700465
78thymic T cell selection (GO:0045061)3.65307215
79regulation of epithelial cell proliferation involved in prostate gland development (GO:0060768)3.64433008
80keratinocyte proliferation (GO:0043616)3.61725194
81intracellular estrogen receptor signaling pathway (GO:0030520)3.57589154
82oxygen transport (GO:0015671)3.55462367
83regulation of MHC class I biosynthetic process (GO:0045343)3.53208416
84positive regulation of B cell proliferation (GO:0030890)3.51513865
85sequestering of metal ion (GO:0051238)3.51151124
86hemoglobin metabolic process (GO:0020027)3.50256238
87regulation of toll-like receptor 4 signaling pathway (GO:0034143)3.49774110
88protein retention in ER lumen (GO:0006621)3.48807392
89negative T cell selection (GO:0043383)3.47488313
90positive regulation of B cell differentiation (GO:0045579)3.44950027
91negative regulation of inclusion body assembly (GO:0090084)3.43877995
92tryptophan metabolic process (GO:0006568)3.42899689
93B cell homeostasis (GO:0001782)3.42079090
94positive regulation of interleukin-12 production (GO:0032735)3.39807483
95response to phenylpropanoid (GO:0080184)3.39579570
96regulation of sequestering of triglyceride (GO:0010889)3.38330053
97germinal center formation (GO:0002467)3.36403486
98B cell activation involved in immune response (GO:0002312)3.35668206
99regulation of interleukin-12 biosynthetic process (GO:0045075)3.35019578
100gas transport (GO:0015669)3.34692636
101regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.33700535
102positive regulation of antigen processing and presentation (GO:0002579)3.32229856
103keratinocyte differentiation (GO:0030216)3.31943498
104erythrocyte development (GO:0048821)3.31890558
105positive regulation of toll-like receptor signaling pathway (GO:0034123)3.29627810
106regulation of type 2 immune response (GO:0002828)3.29542070
107negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)3.28485872
108negative regulation of T cell apoptotic process (GO:0070233)3.27962713
109positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.27069375
110B cell activation (GO:0042113)3.27010844
111retina homeostasis (GO:0001895)3.26687389
112lung lobe morphogenesis (GO:0060463)3.26669054
113epithelial cell maturation (GO:0002070)3.26605948
114detection of external biotic stimulus (GO:0098581)3.26312440
115multicellular organismal water homeostasis (GO:0050891)3.26202398
116water homeostasis (GO:0030104)3.25235269
117cell killing (GO:0001906)3.24247626
118positive T cell selection (GO:0043368)3.22578587
119protoporphyrinogen IX metabolic process (GO:0046501)3.21916638
120somatic diversification of immunoglobulins (GO:0016445)3.21750370
121regulation of chromatin silencing (GO:0031935)3.21747481
122antigen receptor-mediated signaling pathway (GO:0050851)3.21727615
123superoxide anion generation (GO:0042554)3.19657632
124maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.19624869
125negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.19153163
126neutrophil activation involved in immune response (GO:0002283)3.18585940
127neutrophil activation (GO:0042119)3.17639542
128positive regulation of macrophage cytokine production (GO:0060907)3.15858568
129histamine secretion (GO:0001821)3.12519506
130lymph node development (GO:0048535)3.12375889
131peptidyl-proline hydroxylation (GO:0019511)3.12290910
132import into cell (GO:0098657)3.11293000
133regulation of natural killer cell differentiation (GO:0032823)3.11096430
134regulation of steroid hormone secretion (GO:2000831)3.10746344
135negative regulation of potassium ion transmembrane transport (GO:1901380)3.10721156
136establishment of endothelial barrier (GO:0061028)3.09910415
137complement activation, classical pathway (GO:0006958)3.08760417
138immunoglobulin mediated immune response (GO:0016064)3.08158671
139JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)3.07623588
140negative regulation of leukocyte apoptotic process (GO:2000107)3.07504884
141defense response to bacterium (GO:0042742)3.07079697
142positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.06617968
143negative regulation of growth of symbiont in host (GO:0044130)3.03744468
144negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.03744468
145modulation of growth of symbiont involved in interaction with host (GO:0044144)3.03744468
146regulation of growth of symbiont in host (GO:0044126)3.03744468
147regulation of gamma-delta T cell differentiation (GO:0045586)3.02568952
148regulation of lipopolysaccharide-mediated signaling pathway (GO:0031664)3.01117985
149somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.99150344
150isotype switching (GO:0045190)2.99150344
151somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.99150344
152positive regulation of interferon-alpha production (GO:0032727)2.96106589
153lymphocyte homeostasis (GO:0002260)2.95026344
154immune response-activating cell surface receptor signaling pathway (GO:0002429)2.94928388
155leukocyte aggregation (GO:0070486)2.94373243
156biotin metabolic process (GO:0006768)2.94194104
157positive regulation of interleukin-2 production (GO:0032743)2.93865761
158prostate gland epithelium morphogenesis (GO:0060740)2.93266067
159B cell mediated immunity (GO:0019724)2.91476906
160cellular response to ethanol (GO:0071361)2.90439697
161positive regulation of gene expression, epigenetic (GO:0045815)2.87841722
162positive regulation of interleukin-8 biosynthetic process (GO:0045416)2.87403866
163T cell selection (GO:0045058)2.87321563
164regulation of receptor binding (GO:1900120)2.86494279
165granulocyte activation (GO:0036230)2.82341159
166positive regulation of Rap GTPase activity (GO:0032854)2.80202789
167positive regulation of B cell activation (GO:0050871)2.79183984
168myeloid cell development (GO:0061515)2.79170288
169regulation of female gonad development (GO:2000194)2.78530629
170protoporphyrinogen IX biosynthetic process (GO:0006782)2.77132972
171regulation of B cell activation (GO:0050864)2.76789275
172citrulline biosynthetic process (GO:0019240)2.74584981
173response to bacterium (GO:0009617)2.73888122
174regulation of chemokine secretion (GO:0090196)2.73392590
175regulation of interferon-alpha production (GO:0032647)2.72703066
176detection of biotic stimulus (GO:0009595)2.72244141
177regulation of gamma-delta T cell activation (GO:0046643)2.72166942
178epidermal cell differentiation (GO:0009913)2.72055397
179regulation of macrophage cytokine production (GO:0010935)2.69728678
180histone H3-K9 demethylation (GO:0033169)2.64524865
181intracellular steroid hormone receptor signaling pathway (GO:0030518)2.64013124
182cellular response to interleukin-6 (GO:0071354)2.61718056
183COPI coating of Golgi vesicle (GO:0048205)2.60925004
184Golgi transport vesicle coating (GO:0048200)2.60925004
185parturition (GO:0007567)2.59667999
186positive regulation of cellular amide metabolic process (GO:0034250)2.59429053
187positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.58592117
188phagosome maturation (GO:0090382)2.55954385
189response to testosterone (GO:0033574)2.55242083
190mitotic cell cycle arrest (GO:0071850)2.55028183
191androgen receptor signaling pathway (GO:0030521)2.54998477
192regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.54314842
193chemical homeostasis within a tissue (GO:0048875)2.52168160
194cytidine metabolic process (GO:0046087)10.4216067
195cytidine catabolic process (GO:0006216)10.4216067
196cytidine deamination (GO:0009972)10.4216067

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human7.85480012
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse7.07050043
3IRF8_22096565_ChIP-ChIP_GC-B_Mouse5.21342646
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse4.80949695
5MYC_22102868_ChIP-Seq_BL_Human3.96550504
6EGR1_19374776_ChIP-ChIP_THP-1_Human3.52877499
7SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.51291014
8IRF8_21731497_ChIP-ChIP_J774_Mouse3.46415110
9STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.40702815
10IRF8_27001747_Chip-Seq_BMDM_Mouse3.09253983
11RUNX_20019798_ChIP-Seq_JUKART_Human3.05536243
12AR_21909140_ChIP-Seq_LNCAP_Human2.89799920
13STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.81464856
14FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human2.74615318
15AR_21915096_ChIP-Seq_LNCaP-1F5_Human2.73210281
16E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human2.64733634
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.59883482
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.54403386
19MAF_26560356_Chip-Seq_TH1_Human2.48344549
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.42874034
21ZNF217_24962896_ChIP-Seq_MCF-7_Human2.39255624
22HIF1A_21447827_ChIP-Seq_MCF-7_Human2.38337947
23TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.37912559
24* PIAS1_25552417_ChIP-Seq_VCAP_Human2.37563564
25TFAP2C_20629094_ChIP-Seq_MCF-7_Human2.37537785
26MYB_26560356_Chip-Seq_TH1_Human2.36856498
27GATA1_22025678_ChIP-Seq_K562_Human2.33678620
28* FOXA1_25552417_ChIP-Seq_VCAP_Human2.31363313
29MYB_26560356_Chip-Seq_TH2_Human2.28130346
30SOX2_27498859_Chip-Seq_STOMACH_Mouse2.27924781
31ZNF652_21678463_ChIP-ChIP_ZR75-1_Human2.26102327
32VDR_21846776_ChIP-Seq_THP-1_Human2.24082972
33ESR1_20079471_ChIP-ChIP_T-47D_Human2.19815837
34ESR1_21235772_ChIP-Seq_MCF-7_Human2.19491473
35RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.08165745
36CDX2_19796622_ChIP-Seq_MESCs_Mouse2.05913445
37IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.98760414
38NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.98480179
39GATA1_19941826_ChIP-Seq_K562_Human1.97116524
40SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.95627971
41VDR_24763502_ChIP-Seq_THP-1_Human1.89625004
42CHD1_26751641_Chip-Seq_LNCaP_Human1.84394113
43SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83783592
44FOXO3_23340844_ChIP-Seq_DLD1_Human1.83579584
45NOTCH1_21737748_ChIP-Seq_TLL_Human1.80011907
46KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.72910315
47KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.72910315
48KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.72910315
49UTX_26944678_Chip-Seq_JUKART_Human1.70638871
50MYB_21317192_ChIP-Seq_ERMYB_Mouse1.68928112
51STAT4_19710469_ChIP-ChIP_TH1__Mouse1.68207209
52FOXM1_26456572_ChIP-Seq_MCF-7_Human1.62153353
53ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.60987347
54GATA3_24758297_ChIP-Seq_MCF-7_Human1.60712537
55TP63_17297297_ChIP-ChIP_HaCaT_Human1.58719486
56GATA2_21666600_ChIP-Seq_HMVEC_Human1.57770895
57GATA3_27048872_Chip-Seq_THYMUS_Human1.57341617
58CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.53915802
59SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.52008179
60TCF7_22412390_ChIP-Seq_EML_Mouse1.46674429
61VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.46636074
62AHR_22903824_ChIP-Seq_MCF-7_Human1.46480255
63SOX9_24532713_ChIP-Seq_HFSC_Mouse1.46089005
64GATA3_26560356_Chip-Seq_TH1_Human1.44410204
65ARNT_22903824_ChIP-Seq_MCF-7_Human1.42768274
66KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.42756285
67SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39192175
68E2F7_22180533_ChIP-Seq_HELA_Human1.37815402
69STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.37434803
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.37188036
71PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.37127712
72STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.36959370
73SPI1_23547873_ChIP-Seq_NB4_Human1.36251754
74MAF_26560356_Chip-Seq_TH2_Human1.35737295
75SOX2_20726797_ChIP-Seq_SW620_Human1.35511340
76CTNNB1_20460455_ChIP-Seq_HCT116_Human1.30976781
77RXR_22108803_ChIP-Seq_LS180_Human1.30061639
78MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.29443358
79VDR_24787735_ChIP-Seq_THP-1_Human1.28295785
80GATA1_19941827_ChIP-Seq_MEL_Mouse1.27077990
81FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.26427665
82LXR_22158963_ChIP-Seq_LIVER_Mouse1.25114957
83NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.23924771
84RUNX1_22412390_ChIP-Seq_EML_Mouse1.23909333
85ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.22811704
86SPI1_23127762_ChIP-Seq_K562_Human1.21397140
87BRD4_27068464_Chip-Seq_AML-cells_Mouse1.21262268
88SALL4_18804426_ChIP-ChIP_XEN_Mouse1.19151559
89KDM2B_26808549_Chip-Seq_SUP-B15_Human1.17890857
90TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.17434441
91* GATA4_25053715_ChIP-Seq_YYC3_Human1.17176895
92FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.16271106
93NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.15501863
94PPARA_22158963_ChIP-Seq_LIVER_Mouse1.15092124
95ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.13625309
96FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.11777087
97EGR1_19032775_ChIP-ChIP_M12_Human1.11337837
98KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.10937866
99IGF1R_20145208_ChIP-Seq_DFB_Human1.10922906
100AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.09598999
101KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.08948929
102FOXM1_23109430_ChIP-Seq_U2OS_Human1.08514035
103SCL_19346495_ChIP-Seq_HPC-7_Human1.07905558
104KDM2B_26808549_Chip-Seq_DND41_Human1.06485181
105RACK7_27058665_Chip-Seq_MCF-7_Human1.04934870
106SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.04441825
107GATA3_26560356_Chip-Seq_TH2_Human1.04326914
108ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.02861844
109PU_27001747_Chip-Seq_BMDM_Mouse1.02036643
110GATA6_25053715_ChIP-Seq_YYC3_Human1.01134721
111GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99418845
112SMRT_27268052_Chip-Seq_Bcells_Human0.99303724
113Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.98982523
114BP1_19119308_ChIP-ChIP_Hs578T_Human0.97979374
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97734281
116FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.97612804
117SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.95739975
118SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.95739975
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.93261102
120TBX20_22080862_ChIP-Seq_HEART_Mouse0.91426580
121TBX20_22328084_ChIP-Seq_HEART_Mouse0.91426580
122PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91248500
123OCT1_27270436_Chip-Seq_PROSTATE_Human0.90577500
124ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.89859777
125TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.87342639
126SOX11_23321250_ChIP-ChIP_Z138-A519-JVM2_Human0.85886787
127E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.85340578
128PPAR_26484153_Chip-Seq_NCI-H1993_Human0.83472906
129CDX2_20551321_ChIP-Seq_CACO-2_Human0.82334684
130RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.82014039
131TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.79907561
132TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76480407
133CLOCK_20551151_ChIP-Seq_293T_Human0.76154319
134MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.76028954
135ESR1_17901129_ChIP-ChIP_LIVER_Mouse0.74623659
136PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.74504486
137HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.74070309
138GATA2_22383799_ChIP-Seq_G1ME_Mouse0.71269118
139IKZF1_21737484_ChIP-ChIP_HCT116_Human0.71042500
140ELK3_25401928_ChIP-Seq_HUVEC_Human0.70879658
141RXR_22158963_ChIP-Seq_LIVER_Mouse0.69771944
142PU.1_20513432_ChIP-Seq_Bcells_Mouse0.69618253
143FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.69526341
144RUNX1_27514584_Chip-Seq_MCF-7_Human0.69490294
145ELF5_23300383_ChIP-Seq_T47D_Human0.69396508
146GATA1_22383799_ChIP-Seq_G1ME_Mouse0.68862127
147ESR2_21235772_ChIP-Seq_MCF-7_Human0.67450319
148* GATA2_19941826_ChIP-Seq_K562_Human0.67038047
149AR_21572438_ChIP-Seq_LNCaP_Human0.66791652

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002009_preneoplasia8.45536111
2MP0001835_abnormal_antigen_presentation5.25458139
3MP0000537_abnormal_urethra_morphology4.87523869
4MP0001800_abnormal_humoral_immune4.64648514
5MP0005387_immune_system_phenotype4.56248762
6MP0001790_abnormal_immune_system4.56248762
7MP0002452_abnormal_antigen_presenting3.50203178
8MP0003303_peritoneal_inflammation3.47868660
9MP0003315_abnormal_perineum_morphology3.39658440
10MP0000685_abnormal_immune_system3.08145754
11MP0005000_abnormal_immune_tolerance2.97432678
12MP0004145_abnormal_muscle_electrophysio2.97107739
13MP0002723_abnormal_immune_serum2.87002437
14MP0002420_abnormal_adaptive_immunity2.69241619
15MP0001819_abnormal_immune_cell2.64287413
16MP0002254_reproductive_system_inflammat2.50476218
17MP0003300_gastrointestinal_ulcer2.39761016
18MP0005671_abnormal_response_to2.37494335
19MP0002398_abnormal_bone_marrow2.37103400
20MP0001346_abnormal_lacrimal_gland2.32869077
21MP0002148_abnormal_hypersensitivity_rea2.28108020
22MP0000716_abnormal_immune_system2.28074712
23MP0004510_myositis2.12734945
24MP0001853_heart_inflammation2.11196216
25MP0000689_abnormal_spleen_morphology2.06667361
26MP0005636_abnormal_mineral_homeostasis2.04523767
27MP0003656_abnormal_erythrocyte_physiolo2.02936802
28MP0000003_abnormal_adipose_tissue1.97173714
29MP0000465_gastrointestinal_hemorrhage1.97004001
30MP0002933_joint_inflammation1.92994254
31MP0001765_abnormal_ion_homeostasis1.91984190
32MP0003763_abnormal_thymus_physiology1.90560385
33MP0004043_abnormal_pH_regulation1.90527295
34MP0001756_abnormal_urination1.84240053
35MP0003646_muscle_fatigue1.82026783
36MP0004264_abnormal_extraembryonic_tissu1.80583575
37MP0010386_abnormal_urinary_bladder1.80321491
38MP0004947_skin_inflammation1.78130989
39MP0002429_abnormal_blood_cell1.76262560
40MP0002722_abnormal_immune_system1.73627223
41MP0003941_abnormal_skin_development1.72609765
42MP0005025_abnormal_response_to1.69869479
43MP0003436_decreased_susceptibility_to1.65874364
44MP0000013_abnormal_adipose_tissue1.65437551
45MP0002419_abnormal_innate_immunity1.63319025
46MP0002971_abnormal_brown_adipose1.63303742
47MP0002006_tumorigenesis1.61151883
48MP0002796_impaired_skin_barrier1.59366945
49MP0001533_abnormal_skeleton_physiology1.59165572
50MP0008004_abnormal_stomach_pH1.55206111
51MP0001845_abnormal_inflammatory_respons1.54679380
52MP0001873_stomach_inflammation1.53771774
53MP0004036_abnormal_muscle_relaxation1.50178560
54MP0005076_abnormal_cell_differentiation1.49181218
55MP0005310_abnormal_salivary_gland1.46291324
56MP0005275_abnormal_skin_tensile1.43591283
57MP0000538_abnormal_urinary_bladder1.40848584
58MP0002405_respiratory_system_inflammati1.40758636
59MP0003183_abnormal_peptide_metabolism1.38985407
60MP0003191_abnormal_cellular_cholesterol1.38635542
61MP0009785_altered_susceptibility_to1.36208228
62MP0002166_altered_tumor_susceptibility1.34937959
63MP0002160_abnormal_reproductive_system1.29557237
64MP0008961_abnormal_basal_metabolism1.28681871
65MP0010155_abnormal_intestine_physiology1.28647440
66MP0005647_abnormal_sex_gland1.27896455
67MP0003045_fibrosis1.26695878
68MP0002234_abnormal_pharynx_morphology1.24052590
69MP0009764_decreased_sensitivity_to1.22412464
70MP0003566_abnormal_cell_adhesion1.20012988
71MP0004185_abnormal_adipocyte_glucose1.19968481
72MP0005375_adipose_tissue_phenotype1.18005497
73MP0005451_abnormal_body_composition1.13813757
74MP0000703_abnormal_thymus_morphology1.12193866
75MP0003866_abnormal_defecation1.11481143
76MP0000566_synostosis1.08779293
77MP0001919_abnormal_reproductive_system1.08199183
78MP0010234_abnormal_vibrissa_follicle1.06812458
79MP0003195_calcinosis1.04153850
80MP0003868_abnormal_feces_composition1.03353694
81MP0002896_abnormal_bone_mineralization1.02053493
82MP0005389_reproductive_system_phenotype1.00192145
83MP0004130_abnormal_muscle_cell0.99238039
84MP0002138_abnormal_hepatobiliary_system0.97997150
85MP0002019_abnormal_tumor_incidence0.95830793
86MP0008057_abnormal_DNA_replication0.95398369
87MP0000613_abnormal_salivary_gland0.94416629
88MP0002168_other_aberrant_phenotype0.94182544
89MP0005164_abnormal_response_to0.93667794
90MP0002136_abnormal_kidney_physiology0.92980792
91MP0005501_abnormal_skin_physiology0.88284804
92MP0005248_abnormal_Harderian_gland0.87706283
93MP0003448_altered_tumor_morphology0.87197745
94MP0005464_abnormal_platelet_physiology0.86207060
95MP0004808_abnormal_hematopoietic_stem0.84969033
96MP0010352_gastrointestinal_tract_polyps0.84404782
97MP0008260_abnormal_autophagy0.84343080
98MP0001881_abnormal_mammary_gland0.83816127
99MP0004019_abnormal_vitamin_homeostasis0.81796968
100MP0006036_abnormal_mitochondrial_physio0.81268307
101MP0009643_abnormal_urine_homeostasis0.81146280
102MP0005379_endocrine/exocrine_gland_phen0.80282641
103MP0005666_abnormal_adipose_tissue0.78774663
104MP0001191_abnormal_skin_condition0.78337448
105MP0008469_abnormal_protein_level0.77066777
106MP0003453_abnormal_keratinocyte_physiol0.76949333
107MP0009931_abnormal_skin_appearance0.76175598
108MP0010678_abnormal_skin_adnexa0.75734654
109MP0002693_abnormal_pancreas_physiology0.74595870
110MP0002060_abnormal_skin_morphology0.74292116
111MP0008874_decreased_physiological_sensi0.74273041
112MP0002132_abnormal_respiratory_system0.73606653
113MP0000627_abnormal_mammary_gland0.72920362
114MP0004883_abnormal_blood_vessel0.72697041
115MP0001666_abnormal_nutrient_absorption0.72619468
116MP0003828_pulmonary_edema0.72254392
117MP0003075_altered_response_to0.72225252
118MP0000467_abnormal_esophagus_morphology0.72084936
119MP0005187_abnormal_penis_morphology0.70923335
120MP0003690_abnormal_glial_cell0.70872074
121MP0005503_abnormal_tendon_morphology0.69499643
122MP0001879_abnormal_lymphatic_vessel0.69468682
123MP0005535_abnormal_body_temperature0.69317712
124MP0005397_hematopoietic_system_phenotyp0.68981974
125MP0001545_abnormal_hematopoietic_system0.68981974
126MP0003221_abnormal_cardiomyocyte_apopto0.68888905
127MP0003787_abnormal_imprinting0.68523263
128MP0000747_muscle_weakness0.68195688
129MP0009115_abnormal_fat_cell0.66637471
130MP0004858_abnormal_nervous_system0.66597957
131MP0005390_skeleton_phenotype0.66496103
132MP0004147_increased_porphyrin_level0.66123596
133MP0005083_abnormal_biliary_tract0.66079197
134MP0006054_spinal_hemorrhage0.65365361
135MP0002970_abnormal_white_adipose0.65209441
136MP0001727_abnormal_embryo_implantation0.64806522
137MP0000609_abnormal_liver_physiology0.64597160
138MP0004957_abnormal_blastocyst_morpholog0.63237003
139MP0005166_decreased_susceptibility_to0.63164868
140MP0003091_abnormal_cell_migration0.63054202
141MP0001851_eye_inflammation0.61251031
142MP0009765_abnormal_xenobiotic_induced0.60677148
143MP0002108_abnormal_muscle_morphology0.60396346
144MP0000490_abnormal_crypts_of0.59243308
145MP0003724_increased_susceptibility_to0.58638137
146MP0002396_abnormal_hematopoietic_system0.58464320
147MP0001216_abnormal_epidermal_layer0.58335655
148MP0003795_abnormal_bone_structure0.57750134
149MP0005220_abnormal_exocrine_pancreas0.56810872
150MP0010094_abnormal_chromosome_stability0.56453559
151MP0000681_abnormal_thyroid_gland0.55774270
152MP0005621_abnormal_cell_physiology0.55342948
153MP0004484_altered_response_of0.54984612
154MP0002098_abnormal_vibrissa_morphology0.53227547
155MP0000377_abnormal_hair_follicle0.50234395

Predicted human phenotypes

RankGene SetZ-score
1Hyperactive renin-angiotensin system (HP:0000841)8.72206993
2Gastrointestinal stroma tumor (HP:0100723)8.44040746
3Decreased circulating renin level (HP:0003351)8.20728049
4Recurrent bronchitis (HP:0002837)6.85198417
5Recurrent sinusitis (HP:0011108)6.77665106
6Cellulitis (HP:0100658)6.05429463
7Hyperkalemia (HP:0002153)5.95856599
8Prostate neoplasm (HP:0100787)5.76773963
9Chronic bronchitis (HP:0004469)5.71058895
10Colitis (HP:0002583)5.66721870
11Testicular atrophy (HP:0000029)5.54654463
12Abnormality of secondary sexual hair (HP:0009888)5.51638433
13Abnormality of the axillary hair (HP:0100134)5.51638433
14Papilloma (HP:0012740)5.35952787
15Verrucae (HP:0200043)5.35952787
16Chronic otitis media (HP:0000389)5.31314258
17Hypokalemic alkalosis (HP:0001949)5.31095642
18Calf muscle hypertrophy (HP:0008981)5.29846108
19Chronic sinusitis (HP:0011109)5.28219037
20Gonadotropin excess (HP:0000837)5.22496794
21Lymphopenia (HP:0001888)4.94988713
22Lip pit (HP:0100267)4.94195039
23Abnormality of cells of the lymphoid lineage (HP:0012140)4.85358342
24Recurrent lower respiratory tract infections (HP:0002783)4.63894309
25Muscle hypertrophy of the lower extremities (HP:0008968)4.63067893
26Abnormal delayed hypersensitivity skin test (HP:0002963)4.58143133
27IgM deficiency (HP:0002850)4.54209073
28IgA deficiency (HP:0002720)4.51292020
29Inflammation of the large intestine (HP:0002037)4.50145264
30Emphysema (HP:0002097)4.39834543
31Abnormality of renin-angiotensin system (HP:0000847)4.24353795
32Hyperaldosteronism (HP:0000859)4.21870255
33Renal salt wasting (HP:0000127)4.21782693
34Gastrointestinal inflammation (HP:0004386)4.20816398
35Recurrent otitis media (HP:0000403)4.19788243
36Hyponatremia (HP:0002902)4.15451924
37Hypochromic microcytic anemia (HP:0004840)4.13695039
38Meningitis (HP:0001287)4.07718546
39Bronchitis (HP:0012387)4.07567569
40Recurrent pneumonia (HP:0006532)4.00868461
41Abnormality of the heme biosynthetic pathway (HP:0010472)3.93512469
42Osteomyelitis (HP:0002754)3.92048362
43IgG deficiency (HP:0004315)3.85894611
44Flat acetabular roof (HP:0003180)3.81157259
45Vasculitis (HP:0002633)3.80872690
46Recurrent viral infections (HP:0004429)3.80870746
47Panhypogammaglobulinemia (HP:0003139)3.66700439
48Testicular neoplasm (HP:0010788)3.64668577
49Abnormality of sodium homeostasis (HP:0010931)3.63489667
50Autoimmune thrombocytopenia (HP:0001973)3.56781979
51Small epiphyses (HP:0010585)3.52577983
52Recurrent cutaneous fungal infections (HP:0011370)3.46692834
53Chronic mucocutaneous candidiasis (HP:0002728)3.46692834
54Restrictive lung disease (HP:0002091)3.40314541
55Azoospermia (HP:0000027)3.15331657
56Viral hepatitis (HP:0006562)3.15189294
57Sepsis (HP:0100806)3.10789240
58Bifid scrotum (HP:0000048)2.93227165
59Recurrent abscess formation (HP:0002722)2.89387449
60Recurrent fungal infections (HP:0002841)2.82319819
61Recurrent skin infections (HP:0001581)2.73617815
62Abnormality of T cell physiology (HP:0011840)2.70418229
63Flattened epiphyses (HP:0003071)2.69628017
64Skin rash (HP:0000988)2.67810818
65Stomach cancer (HP:0012126)2.66321602
66Recurrent bacterial skin infections (HP:0005406)2.63605410
67Abnormal hemoglobin (HP:0011902)2.62610186
68Absent hair (HP:0002298)2.62579195
69Abnormality of male internal genitalia (HP:0000022)2.54821613
70Abnormality of small intestinal villus morphology (HP:0011472)2.54289741
71Villous atrophy (HP:0011473)2.54289741
72Alkalosis (HP:0001948)2.51676571
73Hypokalemia (HP:0002900)2.49265653
74Poikilocytosis (HP:0004447)2.48485529
75Abnormality of the fingertips (HP:0001211)2.45734995
76Increased IgE level (HP:0003212)2.44959710
77Xerostomia (HP:0000217)2.43830701
78Stenosis of the external auditory canal (HP:0000402)2.39704684
79Bulbar palsy (HP:0001283)2.39252752
80Adrenal overactivity (HP:0002717)2.37267670
81Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.36600248
82Oral leukoplakia (HP:0002745)2.34809889
83Nasal polyposis (HP:0100582)2.34669944
84Lymphoma (HP:0002665)2.32677598
85Leukopenia (HP:0001882)2.31841620
86Autoimmune hemolytic anemia (HP:0001890)2.29409686
87Abnormal spermatogenesis (HP:0008669)2.25577080
88Mediastinal lymphadenopathy (HP:0100721)2.25028851
89Abnormality of the distal phalanx of the thumb (HP:0009617)2.24433083
90Mitral stenosis (HP:0001718)2.24191171
91Thyroiditis (HP:0100646)2.20263925
92B lymphocytopenia (HP:0010976)2.20220112
93Abnormality of B cell number (HP:0010975)2.20220112
94Abnormality of potassium homeostasis (HP:0011042)2.18568074
95Popliteal pterygium (HP:0009756)2.18216641
96Limb hypertonia (HP:0002509)2.18029010
97Abnormality of chloride homeostasis (HP:0011422)2.17735905
98Myocardial infarction (HP:0001658)2.17012646
99Renal cortical cysts (HP:0000803)2.16414840
100Urticaria (HP:0001025)2.15898823
101Neutropenia (HP:0001875)2.14893560
102Abnormal cartilage morphology (HP:0002763)2.14682380
103Abnormality of T cells (HP:0002843)2.14113789
104Hypotension (HP:0002615)2.13388341
105Skin ulcer (HP:0200042)2.13211016
106Eczematoid dermatitis (HP:0000976)2.12122601
107Papilledema (HP:0001085)2.11322632
108Polycythemia (HP:0001901)2.10639420
109Oligomenorrhea (HP:0000876)2.10051344
110Microcytic anemia (HP:0001935)2.09581738
111Encephalitis (HP:0002383)2.04509890
112Vertebral arch anomaly (HP:0008438)2.02265404
113Sparse lateral eyebrow (HP:0005338)2.02082151
114Agammaglobulinemia (HP:0004432)10.0910855
115Ulnar bowing (HP:0003031)1.99186348
116Septate vagina (HP:0001153)1.99183177
117Irregular vertebral endplates (HP:0003301)1.97841641
118Short 1st metacarpal (HP:0010034)1.96495104
119Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.96495104
120Abnormality of T cell number (HP:0011839)1.95302489
121Gingivitis (HP:0000230)1.94432423
122Abnormality of carpal bone ossification (HP:0006257)1.93478606
123Chronic diarrhea (HP:0002028)1.92996081
124Hypochromic anemia (HP:0001931)1.92526892
125Abnormality of the salivary glands (HP:0010286)1.91194781
126Abnormality of the 1st metacarpal (HP:0010009)1.89648560
127Abnormality of the prostate (HP:0008775)1.89443395
128Cystic hygroma (HP:0000476)1.88302301
129Visceral angiomatosis (HP:0100761)1.88104376
130Curly hair (HP:0002212)1.87827247
131Gastrointestinal infarctions (HP:0005244)1.84078748
132Abnormality of the nasal mucosa (HP:0000433)1.83430463
133Hyperpituitarism (HP:0010514)1.82164705
134Dehydration (HP:0001944)1.81992071
135Abnormality of cells of the erythroid lineage (HP:0012130)1.81749507
136Hemangiomatosis (HP:0007461)1.79602235
137Limited elbow extension (HP:0001377)1.78147108
138Recurrent gram-negative bacterial infections (HP:0005420)1.77217631
139Primary adrenal insufficiency (HP:0008207)1.76794831
140Tibial bowing (HP:0002982)1.76452818
141Abnormal foot bone ossification (HP:0010675)1.75517299
142Interstitial pulmonary disease (HP:0006530)1.75271540
143Neonatal hypoglycemia (HP:0001998)1.74861692
144Hepatitis (HP:0012115)1.73127790
145Abnormality of the calf musculature (HP:0001430)1.72048343
146Systemic lupus erythematosus (HP:0002725)1.71869884
147Abnormal tarsal ossification (HP:0008369)1.64481799
148Arthralgia (HP:0002829)1.64174834
149Prolonged bleeding time (HP:0003010)1.63100366
150Bronchiectasis (HP:0002110)1.63032279
151Papillary thyroid carcinoma (HP:0002895)1.62641674
152Volvulus (HP:0002580)1.62206257
153Hypoplasia of the capital femoral epiphysis (HP:0003090)1.61769799
154Eosinophilia (HP:0001880)1.61270481
155Pustule (HP:0200039)1.58628638
156Glomerulonephritis (HP:0000099)1.58622023
157Anhidrosis (HP:0000970)1.57432071
158Metaphyseal cupping (HP:0003021)1.57071822
159Thrombocytosis (HP:0001894)1.56596411
160Cupped ribs (HP:0000887)1.56303960
161Aortic aneurysm (HP:0004942)1.56293453
162Deep philtrum (HP:0002002)1.56010931
163Multiple enchondromatosis (HP:0005701)1.55041267
164Chronic obstructive pulmonary disease (HP:0006510)1.54327953
165Obstructive lung disease (HP:0006536)1.54327953
166Menorrhagia (HP:0000132)1.54205645
167Short phalanx of the thumb (HP:0009660)1.53588347
168Seborrheic dermatitis (HP:0001051)1.53202719
169Camptodactyly of toe (HP:0001836)1.51955717
170Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.50634436
171Polygenic inheritance (HP:0010982)1.49206854
172Congenital ichthyosiform erythroderma (HP:0007431)1.48413321
173Cerebral ischemia (HP:0002637)1.47641418
174Ventricular fibrillation (HP:0001663)1.46819865
175Thickened nuchal skin fold (HP:0000474)1.46598778
176Hypoplasia of the uterus (HP:0000013)1.45781988
177Abnormality of nail color (HP:0100643)1.45219479
178Abnormality of the parathyroid morphology (HP:0011766)1.43818721
179Paralysis (HP:0003470)1.43017603
180Abnormality of macrophages (HP:0004311)1.42614675
181Flat capital femoral epiphysis (HP:0003370)1.42598030

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TNK27.02438644
2MAP4K16.01100606
3MST44.30020090
4FER3.88658227
5CAMK1D3.73702772
6GRK63.27151695
7TAOK13.12495919
8SYK2.85440989
9WNK42.82696799
10CAMK1G2.74819863
11BLK2.61881543
12LRRK22.61300720
13STK102.59084877
14PRKCH2.55936640
15ERN12.54622976
16CSF1R2.53914373
17STK392.23329550
18BTK2.21322964
19TEC1.98039364
20MAP3K141.85098467
21PRKCQ1.79302615
22RIPK41.77750439
23MAP2K31.76504348
24LYN1.73960986
25RPS6KA41.72106321
26KIT1.71557291
27NEK91.68901604
28EIF2AK31.68124465
29ITK1.63854309
30AKT31.62879972
31PRPF4B1.61624261
32MAP3K61.57890373
33YES11.55334018
34LATS11.48590203
35GRK11.48261155
36MAP3K131.47752320
37JAK11.47132589
38MAPKAPK51.44879595
39PDK21.44019432
40MARK21.35025407
41TBK11.33045440
42CSK1.31976506
43MAP3K71.21892735
44IRAK11.19224797
45CLK11.15889390
46TYK21.15351936
47MAPK151.14804392
48MAP3K101.11875445
49EPHB11.11133486
50IKBKB1.09058429
51RPS6KB21.08875509
52PKN21.07346927
53TRPM71.06670088
54PRKCI1.05943995
55ALK1.05873249
56HCK1.05474895
57NLK1.04681555
58FES1.04115258
59STK31.03212138
60SGK31.03150574
61PRKAA21.01256893
62MAP3K20.95205354
63CSNK1A1L0.93547620
64STK240.93400882
65PRKD20.93324296
66IKBKE0.92613038
67RET0.92365646
68SGK20.91083302
69TSSK60.89383415
70KSR20.87131591
71TESK10.86525280
72MAP3K50.86466248
73EPHA30.85719677
74CSNK1G10.83048247
75TAOK30.82456956
76SGK4940.82211868
77SGK2230.82211868
78BRSK20.81433517
79TGFBR20.80288935
80RAF10.79824730
81LCK0.78682243
82HIPK20.77194971
83MATK0.75568788
84PRKD30.74956732
85ABL10.73870190
86MAPKAPK30.72858437
87CDK70.72490143
88IRAK20.71988570
89CDC42BPA0.71971096
90ZAP700.69657162
91FGFR20.69289814
92SIK20.67512817
93INSR0.67278432
94CDK120.66457008
95CHUK0.66340614
96CSNK1G30.65804393
97NEK60.65701411
98PLK40.63967225
99JAK30.62892394
100IRAK40.61533519
101MARK30.60544219
102MAPKAPK20.60089812
103PDPK10.59597241
104FYN0.59518712
105PRKCD0.58677526
106MAP3K10.55450920
107SGK10.54604367
108PLK20.53530032
109CAMKK20.52875317
110FRK0.52472581
111SCYL20.52448029
112FGFR30.52125450
113EEF2K0.51994368
114FGFR40.50847685
115MAP3K30.50484104
116FGR0.50398097
117PDK10.49168590
118PAK20.48703064
119PTK60.48021668
120IRAK30.46762866
121CDK40.45969771
122OXSR10.45775186
123CDK30.44575610
124EPHA20.43459723
125BCR0.43390451
126DAPK20.43344466
127TAOK20.43315681
128PDK30.42815420
129PDK40.42815420
130NUAK10.42345830
131PIM10.42034729
132JAK20.41548805
133SIK10.41119922
134PIK3CG0.40027911
135MTOR0.39271895
136DYRK30.37515867
137MAPK120.37484012
138CSNK1G20.37047858
139BRD40.36470217
140MELK0.35479476
141PDGFRA0.35471962
142PRKAA10.35211493
143TRIB30.34259217
144AKT20.34127441
145PIK3CA0.33922384
146CSNK1D0.33844060
147RPS6KA60.32963095
148RPS6KC10.32684739
149RPS6KL10.32684739
150WNK10.32661607
151CDK90.31895526
152PDGFRB0.30456957
153ERBB30.29909156
154BCKDK0.29647125
155MAPK40.28481133
156ILK0.27237776
157BMPR20.26855273
158MAP2K40.25238685
159PRKCZ0.24857688
160AKT10.21287123

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053407.31723837
2B cell receptor signaling pathway_Homo sapiens_hsa046626.20258492
3Fatty acid biosynthesis_Homo sapiens_hsa000613.80944492
4Intestinal immune network for IgA production_Homo sapiens_hsa046723.77210220
5African trypanosomiasis_Homo sapiens_hsa051433.27397074
6Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.89701303
7Prostate cancer_Homo sapiens_hsa052152.75850221
8NF-kappa B signaling pathway_Homo sapiens_hsa040642.67041464
9Antigen processing and presentation_Homo sapiens_hsa046122.65852146
10ABC transporters_Homo sapiens_hsa020102.48294605
11Hematopoietic cell lineage_Homo sapiens_hsa046402.43467775
12Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.99205192
13Osteoclast differentiation_Homo sapiens_hsa043801.92360264
14mTOR signaling pathway_Homo sapiens_hsa041501.89457604
15Mineral absorption_Homo sapiens_hsa049781.67595572
16Nitrogen metabolism_Homo sapiens_hsa009101.65355369
17Malaria_Homo sapiens_hsa051441.62264638
18Tryptophan metabolism_Homo sapiens_hsa003801.59380958
19Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.55723445
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.53039848
21Base excision repair_Homo sapiens_hsa034101.52746402
22Leishmaniasis_Homo sapiens_hsa051401.43306282
23Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.43049185
24Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.42696686
25Leukocyte transendothelial migration_Homo sapiens_hsa046701.41952795
26Type II diabetes mellitus_Homo sapiens_hsa049301.38771726
27Viral myocarditis_Homo sapiens_hsa054161.38716718
28Pancreatic secretion_Homo sapiens_hsa049721.38093891
29T cell receptor signaling pathway_Homo sapiens_hsa046601.35240188
30Insulin signaling pathway_Homo sapiens_hsa049101.28701225
31Renin-angiotensin system_Homo sapiens_hsa046141.27483608
32Tuberculosis_Homo sapiens_hsa051521.25129920
33Platelet activation_Homo sapiens_hsa046111.24342078
34Amoebiasis_Homo sapiens_hsa051461.21831484
35HIF-1 signaling pathway_Homo sapiens_hsa040661.21378188
36Mismatch repair_Homo sapiens_hsa034301.16756788
37Chemokine signaling pathway_Homo sapiens_hsa040621.14527793
38Apoptosis_Homo sapiens_hsa042101.12873791
39Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.11121451
40Endometrial cancer_Homo sapiens_hsa052131.10294713
41Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.06788157
42Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.05026484
43Circadian rhythm_Homo sapiens_hsa047101.03538145
44Influenza A_Homo sapiens_hsa051641.03476366
45Ribosome_Homo sapiens_hsa030101.01200436
46Toxoplasmosis_Homo sapiens_hsa051451.00110503
47Hepatitis B_Homo sapiens_hsa051610.98315465
48Prolactin signaling pathway_Homo sapiens_hsa049170.97117819
49Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.96707774
50SNARE interactions in vesicular transport_Homo sapiens_hsa041300.91969512
51Staphylococcus aureus infection_Homo sapiens_hsa051500.91747388
52Herpes simplex infection_Homo sapiens_hsa051680.91627786
53Pancreatic cancer_Homo sapiens_hsa052120.91087147
54NOD-like receptor signaling pathway_Homo sapiens_hsa046210.89958271
55AMPK signaling pathway_Homo sapiens_hsa041520.89449568
56Measles_Homo sapiens_hsa051620.87399345
57HTLV-I infection_Homo sapiens_hsa051660.84147392
58RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.83568027
59DNA replication_Homo sapiens_hsa030300.82060244
60Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81699106
61Glioma_Homo sapiens_hsa052140.77817491
62Notch signaling pathway_Homo sapiens_hsa043300.76860321
63Starch and sucrose metabolism_Homo sapiens_hsa005000.75128380
64Regulation of autophagy_Homo sapiens_hsa041400.74596809
65Bladder cancer_Homo sapiens_hsa052190.73152613
66Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.72834194
67Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.69902266
68Thyroid cancer_Homo sapiens_hsa052160.68225441
69MAPK signaling pathway_Homo sapiens_hsa040100.68221184
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.65698388
71Carbohydrate digestion and absorption_Homo sapiens_hsa049730.64169555
72Neurotrophin signaling pathway_Homo sapiens_hsa047220.63124519
73Sphingolipid metabolism_Homo sapiens_hsa006000.61446814
74Jak-STAT signaling pathway_Homo sapiens_hsa046300.60598080
75Adherens junction_Homo sapiens_hsa045200.59960714
76Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59368354
77Endocytosis_Homo sapiens_hsa041440.58780623
78Shigellosis_Homo sapiens_hsa051310.58557536
79Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57944020
80Proteoglycans in cancer_Homo sapiens_hsa052050.57030831
81Fatty acid metabolism_Homo sapiens_hsa012120.56954225
82Glucagon signaling pathway_Homo sapiens_hsa049220.56647592
83p53 signaling pathway_Homo sapiens_hsa041150.56521892
84Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.56254047
85Adipocytokine signaling pathway_Homo sapiens_hsa049200.55476144
86Small cell lung cancer_Homo sapiens_hsa052220.55155399
87TNF signaling pathway_Homo sapiens_hsa046680.54899161
88Legionellosis_Homo sapiens_hsa051340.54117204
89Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51387503
90Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50554671
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50515397
92Focal adhesion_Homo sapiens_hsa045100.49210016
93Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.49007815
94Insulin resistance_Homo sapiens_hsa049310.47983391
95PPAR signaling pathway_Homo sapiens_hsa033200.47754048
96Renal cell carcinoma_Homo sapiens_hsa052110.47482842
97Hepatitis C_Homo sapiens_hsa051600.46808410
98Salivary secretion_Homo sapiens_hsa049700.46447711
99Pathways in cancer_Homo sapiens_hsa052000.46137336
100Rap1 signaling pathway_Homo sapiens_hsa040150.45006174
101Type I diabetes mellitus_Homo sapiens_hsa049400.44781502
102Chronic myeloid leukemia_Homo sapiens_hsa052200.44768369
103Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.43875285
104Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.42734935
105Melanoma_Homo sapiens_hsa052180.42594253
106Non-small cell lung cancer_Homo sapiens_hsa052230.42022852
107Propanoate metabolism_Homo sapiens_hsa006400.41759943
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.41499787
109Histidine metabolism_Homo sapiens_hsa003400.40706351
110Allograft rejection_Homo sapiens_hsa053300.40674227
111Arachidonic acid metabolism_Homo sapiens_hsa005900.39832525
112Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.39237386
113Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.39173364
114Epstein-Barr virus infection_Homo sapiens_hsa051690.38711770
115Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.38640410
116Thyroid hormone signaling pathway_Homo sapiens_hsa049190.37845283
117Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37110866
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.37078762
119Acute myeloid leukemia_Homo sapiens_hsa052210.36819010
120Viral carcinogenesis_Homo sapiens_hsa052030.36711768
121cGMP-PKG signaling pathway_Homo sapiens_hsa040220.36445827
122VEGF signaling pathway_Homo sapiens_hsa043700.35769010
123Salmonella infection_Homo sapiens_hsa051320.35300951
124Colorectal cancer_Homo sapiens_hsa052100.34974155
125Pertussis_Homo sapiens_hsa051330.34285669
126FoxO signaling pathway_Homo sapiens_hsa040680.34172280
127Inositol phosphate metabolism_Homo sapiens_hsa005620.34083668
128Choline metabolism in cancer_Homo sapiens_hsa052310.32490912
129Phospholipase D signaling pathway_Homo sapiens_hsa040720.31801715
130Fatty acid elongation_Homo sapiens_hsa000620.31787956
131Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.31771841
132ErbB signaling pathway_Homo sapiens_hsa040120.31746707
133Estrogen signaling pathway_Homo sapiens_hsa049150.31577056
134Folate biosynthesis_Homo sapiens_hsa007900.31440286
135Nucleotide excision repair_Homo sapiens_hsa034200.31423197
136Sphingolipid signaling pathway_Homo sapiens_hsa040710.30425983
137Dorso-ventral axis formation_Homo sapiens_hsa043200.29684743
138GnRH signaling pathway_Homo sapiens_hsa049120.28684858
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28454321
140Fatty acid degradation_Homo sapiens_hsa000710.27036047

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