CRISPLD1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cartilage development involved in endochondral bone morphogenesis (GO:0060351)7.83741951
2chondrocyte development (GO:0002063)7.09402158
3cell aggregation (GO:0098743)6.89334183
4cartilage condensation (GO:0001502)6.89334183
5keratan sulfate catabolic process (GO:0042340)6.84618964
6negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)6.05808394
7collagen fibril organization (GO:0030199)5.77522459
8phenol-containing compound catabolic process (GO:0019336)5.77086315
9sphingomyelin metabolic process (GO:0006684)5.41804350
10behavioral response to nicotine (GO:0035095)5.28335410
11presynaptic membrane assembly (GO:0097105)4.93652714
12limb bud formation (GO:0060174)4.91253758
13notochord development (GO:0030903)4.67008719
14embryonic skeletal joint morphogenesis (GO:0060272)4.51061397
15chondrocyte proliferation (GO:0035988)4.45847660
16presynaptic membrane organization (GO:0097090)4.39539012
17epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.39314188
18cartilage development (GO:0051216)4.37282780
19replacement ossification (GO:0036075)4.20590986
20endochondral ossification (GO:0001958)4.20590986
21chondrocyte differentiation (GO:0002062)4.12260669
22detection of bacterium (GO:0016045)4.11746597
23sympathetic nervous system development (GO:0048485)4.11539185
24positive regulation of chondrocyte differentiation (GO:0032332)4.05848440
25response to BMP (GO:0071772)3.93875420
26cellular response to BMP stimulus (GO:0071773)3.93875420
27mesenchyme morphogenesis (GO:0072132)3.91294244
28neuronal stem cell maintenance (GO:0097150)3.87415620
29collagen catabolic process (GO:0030574)3.85806388
30pyrimidine nucleobase catabolic process (GO:0006208)3.84900077
31bone trabecula formation (GO:0060346)3.82904493
32endocardial cushion morphogenesis (GO:0003203)3.79553306
33postsynaptic membrane organization (GO:0001941)3.79253195
34positive regulation of cartilage development (GO:0061036)3.77058602
35skeletal system development (GO:0001501)3.74990249
36collagen metabolic process (GO:0032963)3.73691609
37detection of other organism (GO:0098543)3.69990799
38keratan sulfate biosynthetic process (GO:0018146)3.65168053
39epithelial cilium movement (GO:0003351)3.63068613
40chondroitin sulfate biosynthetic process (GO:0030206)3.63003639
41lateral sprouting from an epithelium (GO:0060601)3.59678575
42embryonic viscerocranium morphogenesis (GO:0048703)3.55996495
43facial nerve structural organization (GO:0021612)3.54825150
44proteoglycan metabolic process (GO:0006029)3.54046197
45multicellular organismal macromolecule metabolic process (GO:0044259)3.50479280
46positive regulation of extracellular matrix organization (GO:1903055)3.49527809
47regulation of heart morphogenesis (GO:2000826)3.49439813
48outer ear morphogenesis (GO:0042473)3.48715964
49lymph vessel development (GO:0001945)3.48156788
50nonmotile primary cilium assembly (GO:0035058)3.48031576
51multicellular organismal catabolic process (GO:0044243)3.46697656
52phospholipid scrambling (GO:0017121)3.41269459
53L-serine metabolic process (GO:0006563)3.39292616
54neural crest cell development (GO:0014032)3.32304476
55endothelial cell morphogenesis (GO:0001886)3.28048151
56multicellular organismal metabolic process (GO:0044236)3.25405263
57negative regulation of oligodendrocyte differentiation (GO:0048715)3.24805729
58response to auditory stimulus (GO:0010996)3.23981466
59retinal ganglion cell axon guidance (GO:0031290)3.22451184
60germ cell migration (GO:0008354)3.21723016
61somite development (GO:0061053)3.21279111
62cilium movement (GO:0003341)3.16545365
63regulation of chondrocyte differentiation (GO:0032330)3.15273641
64heart valve formation (GO:0003188)3.13886681
65smooth muscle tissue development (GO:0048745)3.13233745
66mesenchymal cell development (GO:0014031)3.12301372
67definitive hemopoiesis (GO:0060216)3.11622807
68cellular response to cholesterol (GO:0071397)3.07913579
69paraxial mesoderm development (GO:0048339)3.05287605
70intraciliary transport (GO:0042073)3.03951310
71lung-associated mesenchyme development (GO:0060484)3.03499672
72detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.99783287
73neuron projection extension involved in neuron projection guidance (GO:1902284)2.99280670
74axon extension involved in axon guidance (GO:0048846)2.99280670
75cilium or flagellum-dependent cell motility (GO:0001539)2.98901973
76G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.97536461
77neuron cell-cell adhesion (GO:0007158)2.96553059
78positive regulation of hormone biosynthetic process (GO:0046886)2.93198555
79regulation of transforming growth factor beta2 production (GO:0032909)2.92885237
80retinal rod cell development (GO:0046548)2.92874003
81radial glial cell differentiation (GO:0060019)2.92259672
82axonal fasciculation (GO:0007413)2.90114280
83chromatin remodeling at centromere (GO:0031055)2.90033260
84regulation of extracellular matrix disassembly (GO:0010715)2.89914263
85regulation of cell proliferation involved in kidney development (GO:1901722)2.89081849
86segment specification (GO:0007379)2.89065091
87ossification (GO:0001503)2.88824260
88bone development (GO:0060348)2.88795826
89protein heterotrimerization (GO:0070208)2.87951774
90norepinephrine metabolic process (GO:0042415)2.87469580
91cell migration involved in heart development (GO:0060973)2.86915799
92regulation of steroid hormone biosynthetic process (GO:0090030)2.86313489
93cell proliferation involved in kidney development (GO:0072111)2.85504670
94cartilage morphogenesis (GO:0060536)2.85050121
95extracellular matrix disassembly (GO:0022617)2.84745056
96CENP-A containing nucleosome assembly (GO:0034080)2.83630672
97regulation of bone mineralization (GO:0030500)2.81971811
98short-term memory (GO:0007614)2.81373858
99middle ear morphogenesis (GO:0042474)2.81136526
100keratan sulfate metabolic process (GO:0042339)2.80925115
101mechanosensory behavior (GO:0007638)2.80449695
102positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.77685805
103regulation of cartilage development (GO:0061035)2.77582576
104negative regulation of chondrocyte differentiation (GO:0032331)2.76986298
105calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0016339)2.76913332
106axonemal dynein complex assembly (GO:0070286)2.76749483
107otic vesicle formation (GO:0030916)2.76380905
108glycosaminoglycan biosynthetic process (GO:0006024)2.75929676
109aminoglycan biosynthetic process (GO:0006023)2.75378900
110ribosomal small subunit assembly (GO:0000028)2.74793361
111regulation of cardiac muscle cell differentiation (GO:2000725)2.73872341
112regulation of glomerulus development (GO:0090192)2.73553645
113cranial nerve structural organization (GO:0021604)2.73489854
114establishment of skin barrier (GO:0061436)2.72175171
115heart valve morphogenesis (GO:0003179)2.72099421
116nucleobase catabolic process (GO:0046113)2.71838605
117embryonic skeletal system morphogenesis (GO:0048704)2.71337860
118response to gravity (GO:0009629)2.71182004
119auditory behavior (GO:0031223)2.71083235
120positive regulation of cardiac muscle cell differentiation (GO:2000727)2.69893733
121cardiac epithelial to mesenchymal transition (GO:0060317)2.69883666
122mesenchymal cell differentiation (GO:0048762)2.69233348
123regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.68710248
124apical protein localization (GO:0045176)2.67746239
125cholesterol biosynthetic process (GO:0006695)2.66570972
126cilium morphogenesis (GO:0060271)2.64554630
127regulation of development, heterochronic (GO:0040034)2.62770968
128mesenchymal cell proliferation (GO:0010463)2.62238765
129negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)2.61522481
130behavioral response to ethanol (GO:0048149)2.60954638
131neuron recognition (GO:0008038)2.60354936
132regulation of biomineral tissue development (GO:0070167)2.60291261
133stem cell development (GO:0048864)2.60123934
134neuron fate determination (GO:0048664)2.58988539
135limb development (GO:0060173)2.58789239
136appendage development (GO:0048736)2.58789239
137regulation of non-canonical Wnt signaling pathway (GO:2000050)2.58389590
138lens fiber cell development (GO:0070307)2.57896673
139blood vessel maturation (GO:0001955)2.57781953
140cell surface receptor signaling pathway involved in heart development (GO:0061311)2.57379530
141DNA double-strand break processing (GO:0000729)2.57186274
142midbrain development (GO:0030901)2.56701761
143asymmetric protein localization (GO:0008105)2.56560027
144positive regulation of hormone metabolic process (GO:0032352)2.56371083
145peripheral nervous system neuron development (GO:0048935)2.56201056
146organ formation (GO:0048645)2.55754539
147sequestering of extracellular ligand from receptor (GO:0035581)2.55657474
148epithelial to mesenchymal transition (GO:0001837)2.55446119
149planar cell polarity pathway involved in neural tube closure (GO:0090179)2.55139529
150skeletal system morphogenesis (GO:0048705)2.54552592
151positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.49022529
152DNA replication-independent nucleosome assembly (GO:0006336)2.47780342
153DNA replication-independent nucleosome organization (GO:0034724)2.47780342
154negative regulation of glial cell differentiation (GO:0045686)2.47436611
155histone exchange (GO:0043486)2.46838672
156cranial nerve development (GO:0021545)2.46021423
157regulation of penile erection (GO:0060405)2.45226688
158establishment of tissue polarity (GO:0007164)2.42945664
159establishment of planar polarity (GO:0001736)2.42945664
160regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.41622682
161sterol biosynthetic process (GO:0016126)2.41565577
162cilium assembly (GO:0042384)2.40921597
163smoothened signaling pathway (GO:0007224)2.40857641
164cilium organization (GO:0044782)2.39302995
165convergent extension (GO:0060026)2.38751858
166dorsal/ventral axis specification (GO:0009950)2.38216826
167DNA replication-dependent nucleosome organization (GO:0034723)2.37639962
168DNA replication-dependent nucleosome assembly (GO:0006335)2.37639962
169cell proliferation in forebrain (GO:0021846)2.36112395
170vocalization behavior (GO:0071625)2.35832252
171negative chemotaxis (GO:0050919)2.35210508
172Notch signaling involved in heart development (GO:0061314)2.35137514
173mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.33772817
174somatic stem cell division (GO:0048103)2.33285601
175proximal/distal pattern formation (GO:0009954)2.33084615
176positive regulation of synapse assembly (GO:0051965)2.32171275
177negative regulation of axon guidance (GO:1902668)2.31363352
178negative regulation of astrocyte differentiation (GO:0048712)2.30518437
179tongue development (GO:0043586)2.30138637
180establishment of nucleus localization (GO:0040023)2.29947118
181central nervous system projection neuron axonogenesis (GO:0021952)2.29681935
182positive regulation of vascular permeability (GO:0043117)2.29460024
183positive regulation of mitochondrial fission (GO:0090141)2.28787614
184cellular response to sterol (GO:0036315)2.26879947
185pattern specification involved in kidney development (GO:0061004)2.25431074
186transmission of nerve impulse (GO:0019226)2.23716964
187negative regulation of neurotransmitter transport (GO:0051589)2.22569033
188spinal cord association neuron differentiation (GO:0021527)2.19196791
189neuron migration (GO:0001764)2.18142861
190digestive tract morphogenesis (GO:0048546)2.17630940
191astrocyte differentiation (GO:0048708)2.16187954
192C4-dicarboxylate transport (GO:0015740)2.16018760
193spinal cord development (GO:0021510)2.15818165
194cranial nerve morphogenesis (GO:0021602)2.15281066
195dendrite morphogenesis (GO:0048813)2.15003703

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TRIM28_21343339_ChIP-Seq_HEK293_Human4.61586702
2EZH2_22144423_ChIP-Seq_EOC_Human3.40806889
3EED_16625203_ChIP-ChIP_MESCs_Mouse3.05433521
4EZH2_27304074_Chip-Seq_ESCs_Mouse3.00200369
5AR_21572438_ChIP-Seq_LNCaP_Human2.96620925
6SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.84177436
7SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73641058
8SMAD_19615063_ChIP-ChIP_OVARY_Human2.73340535
9SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.72890568
10JARID2_20064375_ChIP-Seq_MESCs_Mouse2.68969972
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.67991483
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.63785005
13* GBX2_23144817_ChIP-Seq_PC3_Human2.61810467
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.58061309
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.58061309
16RBPJ_22232070_ChIP-Seq_NCS_Mouse2.57886510
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.54320328
18JARID2_20075857_ChIP-Seq_MESCs_Mouse2.53028565
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.47557756
20WT1_19549856_ChIP-ChIP_CCG9911_Human2.44540100
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.36394662
22TP63_17297297_ChIP-ChIP_HaCaT_Human2.33229479
23NANOG_18700969_ChIP-ChIP_MESCs_Mouse2.28536377
24SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20511685
25RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.00949900
26PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human2.00732048
27ESR1_21235772_ChIP-Seq_MCF-7_Human1.98329141
28MTF2_20144788_ChIP-Seq_MESCs_Mouse1.90084173
29* ZFP57_27257070_Chip-Seq_ESCs_Mouse1.85274025
30CBX2_27304074_Chip-Seq_ESCs_Mouse1.80176112
31RNF2_27304074_Chip-Seq_ESCs_Mouse1.74818220
32CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.73553908
33NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.72322602
34PIAS1_25552417_ChIP-Seq_VCAP_Human1.70237298
35SOX2_16153702_ChIP-ChIP_HESCs_Human1.68597846
36P300_19829295_ChIP-Seq_ESCs_Human1.67542701
37* TAF15_26573619_Chip-Seq_HEK293_Human1.67040899
38FUS_26573619_Chip-Seq_HEK293_Human1.64794329
39ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.64228647
40TP53_18474530_ChIP-ChIP_U2OS_Human1.63668889
41SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.63496178
42PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.60695918
43CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.60169044
44IGF1R_20145208_ChIP-Seq_DFB_Human1.59797701
45SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.59678204
46CTBP2_25329375_ChIP-Seq_LNCAP_Human1.59539195
47NR3C1_23031785_ChIP-Seq_PC12_Mouse1.59136229
48ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.59107240
49GATA2_21666600_ChIP-Seq_HMVEC_Human1.57080345
50EZH2_27294783_Chip-Seq_ESCs_Mouse1.56917855
51TBX3_20139965_ChIP-Seq_MESCs_Mouse1.51641736
52TBX3_20139965_ChIP-Seq_ESCs_Mouse1.50992394
53TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.50377099
54NR3C1_21868756_ChIP-Seq_MCF10A_Human1.50203296
55SUZ12_27294783_Chip-Seq_ESCs_Mouse1.49965062
56SALL1_21062744_ChIP-ChIP_HESCs_Human1.49591838
57ELK1_19687146_ChIP-ChIP_HELA_Human1.49209841
58ZNF217_24962896_ChIP-Seq_MCF-7_Human1.48759512
59KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.48703402
60VDR_22108803_ChIP-Seq_LS180_Human1.47648354
61POU3F2_20337985_ChIP-ChIP_501MEL_Human1.46832543
62FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.45694081
63CDX2_19796622_ChIP-Seq_MESCs_Mouse1.44271652
64CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.43771479
65* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.41618049
66SMAD3_21741376_ChIP-Seq_EPCs_Human1.41015746
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40762662
68EP300_21415370_ChIP-Seq_HL-1_Mouse1.39945494
69GATA1_22025678_ChIP-Seq_K562_Human1.38911314
70* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.37301737
71* SMAD4_21799915_ChIP-Seq_A2780_Human1.37285811
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.35107227
73TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.34780938
74SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.32964931
75NANOG_16153702_ChIP-ChIP_HESCs_Human1.31945271
76STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.31184292
77NRF2_20460467_ChIP-Seq_MEFs_Mouse1.29820953
78NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.29820953
79CTBP1_25329375_ChIP-Seq_LNCAP_Human1.28436669
80SOX9_26525672_Chip-Seq_HEART_Mouse1.28236217
81CJUN_26792858_Chip-Seq_BT549_Human1.27765250
82CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.27562084
83KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.26495112
84E2F4_17652178_ChIP-ChIP_JURKAT_Human1.26221264
85ZNF274_21170338_ChIP-Seq_K562_Hela1.26183008
86TP63_19390658_ChIP-ChIP_HaCaT_Human1.25939044
87OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23354446
88TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.23343693
89SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23147345
90* POU5F1_18347094_ChIP-ChIP_MESCs_Mouse1.23040424
91POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.22827170
92TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.22827170
93TP53_20018659_ChIP-ChIP_R1E_Mouse1.22741224
94EWS_26573619_Chip-Seq_HEK293_Human1.22478973
95ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.21821015
96RNF2_27304074_Chip-Seq_NSC_Mouse1.21378549
97SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.19184098
98ERG_21242973_ChIP-ChIP_JURKAT_Human1.18913138
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18264594
100POU5F1_16153702_ChIP-ChIP_HESCs_Human1.17619300
101* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16513505
102SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.15824223
103HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.15424403
104GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.14960345
105E2F7_22180533_ChIP-Seq_HELA_Human1.14084387
106ISL1_27105846_Chip-Seq_CPCs_Mouse1.13709355
107PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.12681362
108TOP2B_26459242_ChIP-Seq_MCF-7_Human1.12173459
109* AR_25329375_ChIP-Seq_VCAP_Human1.11687527
110EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.10619803
111KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.10036984
112TCF4_22108803_ChIP-Seq_LS180_Human1.08884532
113FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.08878580
114* FLI1_27457419_Chip-Seq_LIVER_Mouse1.08559204
115* RUNX2_22187159_ChIP-Seq_PCA_Human1.08171081
116RXR_22108803_ChIP-Seq_LS180_Human1.07964953
117WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.07394185
118CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.07352950
119SA1_22415368_ChIP-Seq_MEFs_Mouse1.06602463
120MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.05894269
121POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.05711705
122* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.04786261
123SCL_19346495_ChIP-Seq_HPC-7_Human1.04232850
124RING1B_27294783_Chip-Seq_ESCs_Mouse1.04151214
125CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.02465242
126TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.02332353
127GATA1_26923725_Chip-Seq_HPCs_Mouse1.01818138
128* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01606860
129LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01367813
130SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.00549633
131RING1B_27294783_Chip-Seq_NPCs_Mouse0.99951497
132POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.99565148
133* TAL1_26923725_Chip-Seq_HPCs_Mouse0.98166743
134* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98110538
135JUN_21703547_ChIP-Seq_K562_Human0.97186733
136AR_21909140_ChIP-Seq_LNCAP_Human0.96787122
137* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.96591191
138STAT3_23295773_ChIP-Seq_U87_Human0.96061888
139* NANOG_18555785_Chip-Seq_ESCs_Mouse0.94101775
140HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.93852478
141RARG_19884340_ChIP-ChIP_MEFs_Mouse0.93104229
142ER_23166858_ChIP-Seq_MCF-7_Human0.91289295

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005503_abnormal_tendon_morphology5.58799821
2MP0003136_yellow_coat_color4.66407506
3MP0009250_abnormal_appendicular_skeleto3.78981498
4MP0004134_abnormal_chest_morphology3.72419630
5MP0002933_joint_inflammation3.51114887
6MP0002822_catalepsy3.22297577
7MP0000163_abnormal_cartilage_morphology2.98745509
8MP0009379_abnormal_foot_pigmentation2.98057965
9MP0002282_abnormal_trachea_morphology2.87505402
10MP0000778_abnormal_nervous_system2.80289251
11MP0002115_abnormal_skeleton_extremities2.68410445
12MP0003646_muscle_fatigue2.66607134
13MP0001188_hyperpigmentation2.48497162
14MP0005275_abnormal_skin_tensile2.33091872
15MP0000049_abnormal_middle_ear2.30881784
16MP0001293_anophthalmia2.30527539
17MP0008438_abnormal_cutaneous_collagen2.25697339
18MP0003941_abnormal_skin_development2.24279180
19MP0002089_abnormal_postnatal_growth/wei2.23255434
20MP0005508_abnormal_skeleton_morphology2.22363347
21MP0001270_distended_abdomen2.17707439
22MP0010368_abnormal_lymphatic_system2.15137661
23MP0003123_paternal_imprinting2.14517668
24MP0002653_abnormal_ependyma_morphology2.14102498
25MP0002109_abnormal_limb_morphology2.13270154
26MP0002113_abnormal_skeleton_development2.09606149
27MP0004272_abnormal_basement_membrane2.09554224
28MP0000751_myopathy2.01155379
29MP0001299_abnormal_eye_distance/1.99155287
30MP0000762_abnormal_tongue_morphology1.98374285
31MP0002896_abnormal_bone_mineralization1.95978751
32MP0001984_abnormal_olfaction1.95450694
33MP0003122_maternal_imprinting1.92363070
34MP0005248_abnormal_Harderian_gland1.87962247
35MP0004859_abnormal_synaptic_plasticity1.85061405
36MP0010386_abnormal_urinary_bladder1.79501921
37MP0001529_abnormal_vocalization1.79275850
38MP0003385_abnormal_body_wall1.77835797
39MP0002638_abnormal_pupillary_reflex1.76544427
40MP0000537_abnormal_urethra_morphology1.76191359
41MP0003880_abnormal_central_pattern1.75796341
42MP0002108_abnormal_muscle_morphology1.73805246
43MP0002116_abnormal_craniofacial_bone1.67269375
44MP0002697_abnormal_eye_size1.65545160
45MP0001542_abnormal_bone_strength1.64387672
46MP0005390_skeleton_phenotype1.58737778
47MP0009384_cardiac_valve_regurgitation1.54727184
48MP0009780_abnormal_chondrocyte_physiolo1.53913342
49MP0000569_abnormal_digit_pigmentation1.52028567
50MP0002249_abnormal_larynx_morphology1.51500587
51MP0000516_abnormal_urinary_system1.50297838
52MP0005367_renal/urinary_system_phenotyp1.50297838
53MP0004133_heterotaxia1.49633007
54MP0003279_aneurysm1.49589630
55MP0003283_abnormal_digestive_organ1.44209076
56MP0005187_abnormal_penis_morphology1.40131478
57MP0002233_abnormal_nose_morphology1.37966259
58MP0003119_abnormal_digestive_system1.37727172
59MP0005377_hearing/vestibular/ear_phenot1.37449504
60MP0003878_abnormal_ear_physiology1.37449504
61MP0006072_abnormal_retinal_apoptosis1.35683471
62MP0000579_abnormal_nail_morphology1.35516322
63MP0002938_white_spotting1.34944530
64MP0009278_abnormal_bone_marrow1.33426742
65MP0003121_genomic_imprinting1.33391657
66MP0000955_abnormal_spinal_cord1.32455442
67MP0002092_abnormal_eye_morphology1.32329560
68MP0005394_taste/olfaction_phenotype1.31920232
69MP0005499_abnormal_olfactory_system1.31920232
70MP0003787_abnormal_imprinting1.31507303
71MP0003937_abnormal_limbs/digits/tail_de1.30838154
72MP0003861_abnormal_nervous_system1.30456454
73MP0008789_abnormal_olfactory_epithelium1.30071127
74MP0002090_abnormal_vision1.29975348
75MP0003942_abnormal_urinary_system1.29575236
76MP0004858_abnormal_nervous_system1.28685625
77MP0001879_abnormal_lymphatic_vessel1.27854361
78MP0003935_abnormal_craniofacial_develop1.25918196
79MP0003890_abnormal_embryonic-extraembry1.25040532
80MP0003755_abnormal_palate_morphology1.24807491
81MP0005391_vision/eye_phenotype1.24747340
82MP0005253_abnormal_eye_physiology1.23358981
83MP0004885_abnormal_endolymph1.23283647
84MP0002736_abnormal_nociception_after1.22325188
85MP0002932_abnormal_joint_morphology1.20787383
86MP0004147_increased_porphyrin_level1.18734346
87MP0001486_abnormal_startle_reflex1.17526728
88MP0008932_abnormal_embryonic_tissue1.16798496
89MP0000534_abnormal_ureter_morphology1.15178141
90MP0000432_abnormal_head_morphology1.14950439
91MP0001533_abnormal_skeleton_physiology1.12480510
92MP0003795_abnormal_bone_structure1.11835646
93MP0002114_abnormal_axial_skeleton1.10866074
94MP0000372_irregular_coat_pigmentation1.10803455
95MP0002152_abnormal_brain_morphology1.10707297
96MP0000647_abnormal_sebaceous_gland1.08935003
97MP0008877_abnormal_DNA_methylation1.08654994
98MP0006276_abnormal_autonomic_nervous1.07950169
99MP0002184_abnormal_innervation1.06224779
100MP0010030_abnormal_orbit_morphology1.06081902
101MP0002084_abnormal_developmental_patter1.05392047
102MP0009697_abnormal_copulation1.04990476
103MP0002752_abnormal_somatic_nervous1.02376293
104MP0003938_abnormal_ear_development1.00592238
105MP0010094_abnormal_chromosome_stability0.99303114
106MP0004484_altered_response_of0.98778491
107MP0002909_abnormal_adrenal_gland0.98674369
108MP0003011_delayed_dark_adaptation0.98439886
109MP0002085_abnormal_embryonic_tissue0.97421992
110MP0006054_spinal_hemorrhage0.97227919
111MP0009053_abnormal_anal_canal0.97188398
112MP0005195_abnormal_posterior_eye0.95502828
113MP0004808_abnormal_hematopoietic_stem0.93497642
114MP0001485_abnormal_pinna_reflex0.93304437
115MP0008058_abnormal_DNA_repair0.93180774
116MP0002735_abnormal_chemical_nociception0.92312160
117MP0002557_abnormal_social/conspecific_i0.90563336
118MP0002882_abnormal_neuron_morphology0.89919769
119MP0003315_abnormal_perineum_morphology0.88283154
120MP0009703_decreased_birth_body0.87719745
121MP0005423_abnormal_somatic_nervous0.86649298
122MP0002095_abnormal_skin_pigmentation0.86404581
123MP0003077_abnormal_cell_cycle0.86220601
124MP0002177_abnormal_outer_ear0.85612211
125MP0003828_pulmonary_edema0.85484633
126MP0006292_abnormal_olfactory_placode0.85215930
127MP0002163_abnormal_gland_morphology0.85183052
128MP0000428_abnormal_craniofacial_morphol0.84626824
129MP0002572_abnormal_emotion/affect_behav0.83753920
130MP0001324_abnormal_eye_pigmentation0.83718704
131MP0000383_abnormal_hair_follicle0.83596830
132MP0004270_analgesia0.83459165
133MP0001545_abnormal_hematopoietic_system0.83413679
134MP0005397_hematopoietic_system_phenotyp0.83413679
135MP0008007_abnormal_cellular_replicative0.83265438
136MP0005409_darkened_coat_color0.82820370
137MP0002111_abnormal_tail_morphology0.80858461
138MP0000631_abnormal_neuroendocrine_gland0.80659343
139MP0002060_abnormal_skin_morphology0.77238121
140MP0000538_abnormal_urinary_bladder0.76311337
141MP0002751_abnormal_autonomic_nervous0.74715990
142MP0002998_abnormal_bone_remodeling0.73738685
143MP0001963_abnormal_hearing_physiology0.73567937
144MP0002796_impaired_skin_barrier0.68088710
145MP0000767_abnormal_smooth_muscle0.65136557
146MP0001286_abnormal_eye_development0.64584952
147MP0001340_abnormal_eyelid_morphology0.63667679
148MP0000026_abnormal_inner_ear0.63050804
149MP0005174_abnormal_tail_pigmentation0.59194389
150MP0002102_abnormal_ear_morphology0.59048973
151MP0003656_abnormal_erythrocyte_physiolo0.58244257
152MP0005171_absent_coat_pigmentation0.57677511
153MP0003567_abnormal_fetal_cardiomyocyte0.57608471
154MP0001905_abnormal_dopamine_level0.57237561
155MP0000566_synostosis0.57016314
156MP0000462_abnormal_digestive_system0.56133739
157MP0001943_abnormal_respiration0.54311119
158MP0001177_atelectasis0.53275640
159MP0002234_abnormal_pharynx_morphology0.52204061
160MP0005197_abnormal_uvea_morphology0.51623649

Predicted human phenotypes

RankGene SetZ-score
1Epiphyseal dysplasia (HP:0002656)8.66671949
2Irregular epiphyses (HP:0010582)8.00181107
3Vitreoretinal degeneration (HP:0000655)6.51297604
4Small epiphyses (HP:0010585)6.30786696
5Hypoplastic ischia (HP:0003175)5.60240755
6Metaphyseal dysplasia (HP:0100255)5.14706676
7Delayed epiphyseal ossification (HP:0002663)5.13751793
8Aplasia/Hypoplasia of the pubic bone (HP:0009104)5.12439822
9Flat capital femoral epiphysis (HP:0003370)5.09405029
10Cupped ribs (HP:0000887)5.06788789
11Abnormal tarsal ossification (HP:0008369)4.98937279
12Genu varum (HP:0002970)4.95712874
13Abnormality of the ischium (HP:0003174)4.89815504
14Metaphyseal cupping (HP:0003021)4.62166678
15Mild short stature (HP:0003502)4.45508591
16Abnormality of femoral epiphyses (HP:0006499)4.30543092
17Abnormality involving the epiphyses of the lower limbs (HP:0006500)4.30543092
18Abnormality of the vertebral endplates (HP:0005106)4.09089345
19Neonatal short-limb short stature (HP:0008921)4.07618087
20Abnormality of the epiphysis of the femoral head (HP:0010574)4.03332073
21Irregular vertebral endplates (HP:0003301)3.97833254
22Flat acetabular roof (HP:0003180)3.94757301
23Abnormality of the femoral head (HP:0003368)3.78214003
24Short femoral neck (HP:0100864)3.73526315
25Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)3.72869215
26Absent epiphyses (HP:0010577)3.72869215
27Osteoarthritis (HP:0002758)3.64717203
28Arthropathy (HP:0003040)3.53965815
29Flattened epiphyses (HP:0003071)3.52378853
30Abnormal foot bone ossification (HP:0010675)3.51470261
31Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)3.46005930
32Abnormality of the pubic bones (HP:0003172)3.23915328
33Abnormality of the phalanges of the 2nd finger (HP:0009541)3.21214370
34Septo-optic dysplasia (HP:0100842)3.20483761
35Metaphyseal irregularity (HP:0003025)3.12471176
36Platyspondyly (HP:0000926)3.07760356
37Abnormality of carpal bone ossification (HP:0006257)3.05833614
38Mesomelia (HP:0003027)3.04829866
39Limited hip movement (HP:0008800)3.02886418
40Beaking of vertebral bodies (HP:0004568)2.99836236
41Enlarged epiphyses (HP:0010580)2.98859312
42Limited elbow extension (HP:0001377)2.95540471
43Coxa vara (HP:0002812)2.95323981
44Split foot (HP:0001839)2.88272897
45Cervical subluxation (HP:0003308)2.85857017
46Waddling gait (HP:0002515)2.77966214
47Abnormality of the labia minora (HP:0012880)2.77014633
48True hermaphroditism (HP:0010459)2.72760984
49Neonatal hypoglycemia (HP:0001998)2.70458838
50Abnormality of the proximal phalanges of the hand (HP:0009834)2.66738880
51Aplasia/hypoplasia of the femur (HP:0005613)2.66263183
52Cutaneous finger syndactyly (HP:0010554)2.65262612
53Hepatoblastoma (HP:0002884)2.63022653
54Hip contracture (HP:0003273)2.61835734
55Exostoses (HP:0100777)2.61261725
56Ovoid vertebral bodies (HP:0003300)2.59538693
57Lumbar hyperlordosis (HP:0002938)2.58247785
58Carpal bone hypoplasia (HP:0001498)2.57635831
59Abnormal vertebral ossification (HP:0100569)2.54610920
60Hypothermia (HP:0002045)2.53996459
61Polyphagia (HP:0002591)2.51837493
62Anophthalmia (HP:0000528)2.51350886
63Abnormal hand bone ossification (HP:0010660)2.49261509
64Abnormality of the 2nd finger (HP:0004100)2.49068123
65Abnormal ciliary motility (HP:0012262)2.48798371
66Hyperglycinemia (HP:0002154)2.47753295
67Colon cancer (HP:0003003)2.47307626
68Esophageal atresia (HP:0002032)2.45283557
69Spinal cord compression (HP:0002176)2.44458066
70Aplasia/Hypoplasia involving the pelvis (HP:0009103)2.43661529
71Broad foot (HP:0001769)2.42974385
72Abnormal ossification of hand bones (HP:0005921)2.42583551
73Barrel-shaped chest (HP:0001552)2.42386763
74Cutaneous syndactyly (HP:0012725)2.40018270
75Micromelia (HP:0002983)2.39414879
76Abnormality of incisor morphology (HP:0011063)2.39033194
77Glossoptosis (HP:0000162)2.37389444
78Turricephaly (HP:0000262)2.36784051
79Gait imbalance (HP:0002141)2.36066900
80Abnormal respiratory epithelium morphology (HP:0012253)2.34611795
81Abnormal respiratory motile cilium morphology (HP:0005938)2.34611795
82Cortical dysplasia (HP:0002539)2.33078632
83Genital tract atresia (HP:0001827)2.32692148
84Pancreatic fibrosis (HP:0100732)2.32554447
85Vaginal atresia (HP:0000148)2.31660509
86Supernumerary spleens (HP:0009799)2.31369607
87Hypoplasia of the odontoid process (HP:0003311)2.30767569
88Thoracolumbar scoliosis (HP:0002944)2.30470255
89Coronal craniosynostosis (HP:0004440)2.29726765
90Short middle phalanx of finger (HP:0005819)2.28619834
91Congenital primary aphakia (HP:0007707)2.27764161
92Bifid tongue (HP:0010297)2.26027036
93Hypoplastic pelvis (HP:0008839)2.25884699
94Medial flaring of the eyebrow (HP:0010747)2.25796047
95Abnormal respiratory motile cilium physiology (HP:0012261)2.24133350
96Postaxial hand polydactyly (HP:0001162)2.23940205
97Mixed hearing impairment (HP:0000410)2.23724590
98Oligodactyly (hands) (HP:0001180)2.19867438
99Abnormality of the phalanges of the 5th finger (HP:0004213)2.18176686
100Protrusio acetabuli (HP:0003179)2.18043174
101Protuberant abdomen (HP:0001538)2.16952192
102Absent frontal sinuses (HP:0002688)2.16278973
103Gastrointestinal atresia (HP:0002589)2.15914113
104Trigonocephaly (HP:0000243)2.15433545
105Pancreatic cysts (HP:0001737)2.14867698
106Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.14312241
107Flared metaphyses (HP:0003015)2.13529693
108Renal hypoplasia (HP:0000089)2.13292425
109Radial bowing (HP:0002986)2.12760278
110Abnormality of midbrain morphology (HP:0002418)2.12036384
111Molar tooth sign on MRI (HP:0002419)2.12036384
112Hemiparesis (HP:0001269)2.07670123
113Broad phalanx (HP:0006009)2.06953340
114Absent/shortened dynein arms (HP:0200106)2.05700909
115Dynein arm defect of respiratory motile cilia (HP:0012255)2.05700909
116Myelomeningocele (HP:0002475)2.04991004
117Broad long bones (HP:0005622)2.03595466
118Vertebral clefting (HP:0008428)2.02629839
119Hemivertebrae (HP:0002937)2.02557725
120Occipital encephalocele (HP:0002085)2.02298927
121Oligodactyly (HP:0012165)2.02096552
122Abnormality of the middle phalanges of the toes (HP:0010183)2.01480377
123Volvulus (HP:0002580)2.01131385
124Follicular hyperkeratosis (HP:0007502)1.99478839
125Postaxial foot polydactyly (HP:0001830)1.98785652
126Aplasia/Hypoplasia of the sternum (HP:0006714)1.98039999
127Preaxial hand polydactyly (HP:0001177)1.97512500
128Abnormality of glycine metabolism (HP:0010895)1.97112913
129Abnormality of serine family amino acid metabolism (HP:0010894)1.97112913
130Decreased skull ossification (HP:0004331)1.96647786
131Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.96442420
132Absent septum pellucidum (HP:0001331)1.95257619
133Severe Myopia (HP:0011003)1.95070181
134Hypoplastic ilia (HP:0000946)1.95059699
135Nephrogenic diabetes insipidus (HP:0009806)1.94951056
136Stillbirth (HP:0003826)1.93786551
137Patchy hypopigmentation of hair (HP:0011365)1.93140465
138Morphological abnormality of the middle ear (HP:0008609)1.92054763
139Abnormality of the acetabulum (HP:0003170)1.91470451
140Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.91171465
141White forelock (HP:0002211)1.90543742
142Biconcave vertebral bodies (HP:0004586)1.90537246
143Aplasia involving bones of the upper limbs (HP:0009823)1.90508873
144Aplasia of the phalanges of the hand (HP:0009802)1.90508873
145Aplasia involving bones of the extremities (HP:0009825)1.90508873
146Hyperglycinuria (HP:0003108)1.90092049
147Preaxial foot polydactyly (HP:0001841)1.89889241
148Abnormality of the vitreous humor (HP:0004327)1.88038617
149Short tibia (HP:0005736)1.87582494
150Abnormality of the middle phalanges of the hand (HP:0009833)1.86951324
151Abnormality of the diencephalon (HP:0010662)1.86264890
152Disproportionate short-trunk short stature (HP:0003521)1.85974518
153Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.84199593
154Megalencephaly (HP:0001355)1.84102767
155Abnormality of the odontoid process (HP:0003310)1.83486382
156Short ribs (HP:0000773)1.83456330
157Partial duplication of thumb phalanx (HP:0009944)1.82033442
158Exercise-induced muscle cramps (HP:0003710)1.81935871
159Aplasia/Hypoplasia of the middle phalanges of the hand (HP:0009843)1.80026571
160Omphalocele (HP:0001539)1.79781133
161Optic nerve hypoplasia (HP:0000609)1.79710533
162Aplasia/Hypoplasia of the fibula (HP:0006492)1.79680642
163Relative macrocephaly (HP:0004482)1.79488243
164Aplasia/Hypoplasia of the tibia (HP:0005772)1.79320252
165Round face (HP:0000311)1.78718877
166Rhizomelia (HP:0008905)1.78619903
167High anterior hairline (HP:0009890)1.77832144
168Abnormality of the lumbar spine (HP:0100712)1.77424568
169Fibular hypoplasia (HP:0003038)1.77161291
170Nephronophthisis (HP:0000090)1.77034867
171Specific learning disability (HP:0001328)1.76416271
172Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.76312139
173Anencephaly (HP:0002323)1.75916899
174Abnormality of the 4th metacarpal (HP:0010012)1.75593227
175Maternal diabetes (HP:0009800)1.75314773
176Heterochromia iridis (HP:0001100)1.74417415
177Broad ribs (HP:0000885)1.74411034
178Poor coordination (HP:0002370)1.74010138
179Sprengel anomaly (HP:0000912)1.73754878
180Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.73491584
181Short 4th metacarpal (HP:0010044)1.73491584
182Intestinal atresia (HP:0011100)1.71785994
183Abnormality of the septum pellucidum (HP:0007375)1.70529924
184Drooling (HP:0002307)1.70433294
185Median cleft lip (HP:0000161)1.69948816
186Rhinitis (HP:0012384)1.67473993
187Shoulder girdle muscle weakness (HP:0003547)1.67404399
188Meckel diverticulum (HP:0002245)1.67123383
189Synostosis of carpal bones (HP:0005048)1.66843349
190Sclerocornea (HP:0000647)1.66175337
191Wide anterior fontanel (HP:0000260)1.65974124
192Aplasia/Hypoplasia of the tongue (HP:0010295)1.65480223
193Triphalangeal thumb (HP:0001199)1.64751914
194Abnormality of the musculature of the pelvis (HP:0001469)1.64680979
195Abnormality of the hip-girdle musculature (HP:0001445)1.64680979

Predicted kinase interactions (KEA)

RankGene SetZ-score
1DDR27.02022891
2TIE13.71406989
3PNCK2.89773731
4NTRK22.85176766
5PRKG22.77605328
6MAP3K32.76088705
7STK242.65417575
8WEE12.63207166
9MUSK2.60634825
10BCR2.42317020
11MAPK152.42118419
12STK38L2.31988671
13TGFBR12.13183000
14CDC72.11197884
15CASK2.11186406
16MATK2.10183751
17NLK2.10068087
18NTRK11.99715670
19STK161.98850898
20WNK31.91227342
21MARK11.87659496
22CSNK1G21.86840263
23PIM21.82868852
24NME21.81641673
25FLT31.81264804
26MKNK11.78362055
27ERBB31.76855025
28MAP2K71.73223050
29MKNK21.73139722
30TRPM71.72022706
31DYRK21.57256419
32INSRR1.51132188
33GRK71.49005783
34TRIM281.44701647
35CDK81.43685599
36TGFBR21.43005108
37TNIK1.38389326
38BCKDK1.37152489
39TSSK61.36128002
40KDR1.35763311
41NME11.33946774
42PLK41.28475078
43YES11.27452711
44EPHA41.25462964
45BMPR1B1.25121834
46PLK21.24458673
47CSNK1A1L1.22857234
48KIT1.22290855
49TTK1.22001854
50MAP3K121.21107765
51LATS11.17844323
52MYLK1.17783755
53FGFR21.14979657
54MAPK71.11512779
55RPS6KA41.11076644
56NUAK11.10704414
57NEK11.05154114
58PAK61.02980608
59CAMKK21.02192637
60MOS1.01918880
61MAPK121.01452008
62MAP3K41.00818957
63MAPKAPK30.96834309
64ADRBK10.96251153
65PBK0.96173690
66PLK10.95311502
67EPHB20.95111650
68VRK20.94012918
69MAP2K30.92326270
70MAPKAPK50.91807297
71MAP4K20.91213163
72CDK190.90166228
73DYRK30.90045048
74TEC0.89840616
75MAPK130.89562406
76UHMK10.87088470
77ROCK20.84239528
78GRK10.83089962
79NEK20.82859935
80GRK50.80312229
81PRKCG0.74812401
82TAF10.74501938
83PRKCE0.73883533
84DYRK1A0.70606769
85STK390.70346299
86NEK90.70063574
87BRD40.68707385
88TYRO30.68402152
89KSR10.67996833
90MAPK40.67988736
91ZAK0.67758484
92PIK3CA0.66717244
93FGFR10.66477648
94OBSCN0.65474881
95PTK2B0.65342077
96ADRBK20.64933833
97ATR0.63389725
98PINK10.62921601
99EPHA30.62839860
100CAMK1G0.61689017
101PKN10.59876365
102NTRK30.59822326
103FER0.59808561
104IGF1R0.57714577
105MET0.55703290
106ATM0.54550333
107STK30.54201865
108LATS20.53585719
109MST1R0.53435442
110BUB10.52825000
111CDK90.52230646
112PAK20.52188985
113TAOK20.52067744
114SIK30.51865895
115CDK50.51445812
116PRKDC0.50795775
117CDK60.48834387
118MAP3K60.46908170
119EIF2AK20.46736498
120DAPK10.46691415
121MAP2K10.46000716
122CDK140.45551640
123MAP3K100.45517243
124CDK180.45461266
125CSNK1G10.45385587
126CAMK10.44923812
127ERBB40.44614671
128PAK40.44287343
129PRKG10.42366961
130PASK0.42318866
131CAMK40.41390114
132CDK150.41224415
133CDK11A0.41196260
134BRSK20.40615203
135CAMK2A0.39852762
136DMPK0.39293421
137ACVR1B0.39061317
138CDK70.37702511
139PRKD30.37275632
140CCNB10.37235891
141CSNK1E0.37005694
142SRPK10.36550678
143PDGFRA0.35242448
144MELK0.35078427
145VRK10.33882370
146MAP2K40.32145958
147MAPK30.31481804
148CDK30.31230634
149RPS6KA20.30749473
150CSF1R0.30002991
151FES0.29945742
152CSNK1G30.29733518
153ERBB20.29262246
154EEF2K0.28946083
155RPS6KA60.28719034
156ROCK10.28227809
157TAOK10.27739859
158PLK30.27242724
159SIK10.26604321
160BTK0.25876103

Predicted pathways (KEGG)

RankGene SetZ-score
1ECM-receptor interaction_Homo sapiens_hsa045124.53327633
2Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005324.35679676
3Protein digestion and absorption_Homo sapiens_hsa049743.89150746
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.66809341
5Steroid biosynthesis_Homo sapiens_hsa001003.07884960
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009002.76828965
7Sphingolipid metabolism_Homo sapiens_hsa006002.45845781
8Propanoate metabolism_Homo sapiens_hsa006402.25824143
9Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.22056335
10Focal adhesion_Homo sapiens_hsa045101.96926773
11Mismatch repair_Homo sapiens_hsa034301.96130744
12Olfactory transduction_Homo sapiens_hsa047401.91935148
13Ribosome_Homo sapiens_hsa030101.89392672
14Basal cell carcinoma_Homo sapiens_hsa052171.87336337
15Fanconi anemia pathway_Homo sapiens_hsa034601.86863131
16Hedgehog signaling pathway_Homo sapiens_hsa043401.81614807
17Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.81094154
18Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.73129884
19Malaria_Homo sapiens_hsa051441.71712813
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.70275903
21Long-term depression_Homo sapiens_hsa047301.63149866
22Other types of O-glycan biosynthesis_Homo sapiens_hsa005141.62910012
23Circadian entrainment_Homo sapiens_hsa047131.59621858
24PI3K-Akt signaling pathway_Homo sapiens_hsa041511.59085908
25Wnt signaling pathway_Homo sapiens_hsa043101.58886900
26TGF-beta signaling pathway_Homo sapiens_hsa043501.58236562
27DNA replication_Homo sapiens_hsa030301.57930312
28Spliceosome_Homo sapiens_hsa030401.55104323
29Amphetamine addiction_Homo sapiens_hsa050311.52210208
30Cocaine addiction_Homo sapiens_hsa050301.49779505
31Butanoate metabolism_Homo sapiens_hsa006501.48688168
32Cell cycle_Homo sapiens_hsa041101.36109182
33RNA degradation_Homo sapiens_hsa030181.34416842
34Melanogenesis_Homo sapiens_hsa049161.28779615
35Nicotine addiction_Homo sapiens_hsa050331.28289636
36Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.28045756
37Cholinergic synapse_Homo sapiens_hsa047251.22730068
38Serotonergic synapse_Homo sapiens_hsa047261.21410850
39Aldosterone synthesis and secretion_Homo sapiens_hsa049251.20751715
40Nucleotide excision repair_Homo sapiens_hsa034201.20192927
41RNA transport_Homo sapiens_hsa030131.20078575
42Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.19876975
43Fatty acid elongation_Homo sapiens_hsa000621.19594823
44Protein export_Homo sapiens_hsa030601.19349503
45Axon guidance_Homo sapiens_hsa043601.17785511
46Cysteine and methionine metabolism_Homo sapiens_hsa002701.17405922
47Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.16742390
48Biosynthesis of amino acids_Homo sapiens_hsa012301.16016661
49SNARE interactions in vesicular transport_Homo sapiens_hsa041301.15679455
50Dopaminergic synapse_Homo sapiens_hsa047281.15603408
51Salivary secretion_Homo sapiens_hsa049701.15410995
52Renin secretion_Homo sapiens_hsa049241.13183572
53Thyroid cancer_Homo sapiens_hsa052161.12653709
54Fatty acid metabolism_Homo sapiens_hsa012121.12581086
55RNA polymerase_Homo sapiens_hsa030201.11960799
56Ovarian steroidogenesis_Homo sapiens_hsa049131.11538300
57African trypanosomiasis_Homo sapiens_hsa051431.11460257
58Pyruvate metabolism_Homo sapiens_hsa006201.11333682
59cGMP-PKG signaling pathway_Homo sapiens_hsa040221.09851059
60Selenocompound metabolism_Homo sapiens_hsa004501.09676520
61Basal transcription factors_Homo sapiens_hsa030221.09624116
62Hippo signaling pathway_Homo sapiens_hsa043901.09507224
63Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.09140087
64Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.08353522
65Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.07816594
66Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.06984187
67Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.06725717
68Gap junction_Homo sapiens_hsa045401.06332985
69Base excision repair_Homo sapiens_hsa034101.04764674
70Oocyte meiosis_Homo sapiens_hsa041141.02925538
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.02435041
72Nitrogen metabolism_Homo sapiens_hsa009101.02062683
73AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.01004602
74Dilated cardiomyopathy_Homo sapiens_hsa054140.99257186
75mRNA surveillance pathway_Homo sapiens_hsa030150.96543982
76Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.95381835
77Huntingtons disease_Homo sapiens_hsa050160.95053494
78Platelet activation_Homo sapiens_hsa046110.95001307
79Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.93699691
80Calcium signaling pathway_Homo sapiens_hsa040200.93562260
81Peroxisome_Homo sapiens_hsa041460.93035251
82beta-Alanine metabolism_Homo sapiens_hsa004100.92887763
83Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.92657583
84Oxytocin signaling pathway_Homo sapiens_hsa049210.92273811
85Proteasome_Homo sapiens_hsa030500.92102574
86Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.91956722
87Parkinsons disease_Homo sapiens_hsa050120.90122202
88Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.89194210
89Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.88228757
90Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.86737560
91Long-term potentiation_Homo sapiens_hsa047200.85268618
92Carbon metabolism_Homo sapiens_hsa012000.84527947
93Tight junction_Homo sapiens_hsa045300.84381844
94Glutamatergic synapse_Homo sapiens_hsa047240.82197964
95Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.79648037
96Notch signaling pathway_Homo sapiens_hsa043300.78863203
97Primary bile acid biosynthesis_Homo sapiens_hsa001200.76742031
98Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.75934627
99Transcriptional misregulation in cancer_Homo sapiens_hsa052020.75702725
100Proteoglycans in cancer_Homo sapiens_hsa052050.74393939
101Phototransduction_Homo sapiens_hsa047440.73460582
102Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.72572708
103cAMP signaling pathway_Homo sapiens_hsa040240.72559760
104Taste transduction_Homo sapiens_hsa047420.72373548
105Tyrosine metabolism_Homo sapiens_hsa003500.71320294
106Morphine addiction_Homo sapiens_hsa050320.70540428
107Oxidative phosphorylation_Homo sapiens_hsa001900.69792620
108Rheumatoid arthritis_Homo sapiens_hsa053230.69081607
109Rap1 signaling pathway_Homo sapiens_hsa040150.66921462
110Cardiac muscle contraction_Homo sapiens_hsa042600.66329701
111Pathways in cancer_Homo sapiens_hsa052000.64924539
112Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.61814134
113Non-homologous end-joining_Homo sapiens_hsa034500.61581315
114Arginine and proline metabolism_Homo sapiens_hsa003300.61271980
115GABAergic synapse_Homo sapiens_hsa047270.61158623
116Lysine degradation_Homo sapiens_hsa003100.61083993
117Vascular smooth muscle contraction_Homo sapiens_hsa042700.58848117
118Adherens junction_Homo sapiens_hsa045200.57170865
119Insulin secretion_Homo sapiens_hsa049110.56460737
120Vitamin B6 metabolism_Homo sapiens_hsa007500.55998380
121GnRH signaling pathway_Homo sapiens_hsa049120.55696136
1222-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.55015860
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.54026048
124Estrogen signaling pathway_Homo sapiens_hsa049150.53894225
125Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.53193541
126Alzheimers disease_Homo sapiens_hsa050100.52841468
127Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.50598495
128Ras signaling pathway_Homo sapiens_hsa040140.48970710
129Neurotrophin signaling pathway_Homo sapiens_hsa047220.48911722
130Vibrio cholerae infection_Homo sapiens_hsa051100.48620219
131Thyroid hormone synthesis_Homo sapiens_hsa049180.48069996
132Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.47867485
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.45633849
134Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.45491356
135One carbon pool by folate_Homo sapiens_hsa006700.45331113
136Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.45055837
137Fatty acid degradation_Homo sapiens_hsa000710.44877310
138Colorectal cancer_Homo sapiens_hsa052100.44848342
139Melanoma_Homo sapiens_hsa052180.44765920
140Sulfur metabolism_Homo sapiens_hsa009200.44699830
141Metabolic pathways_Homo sapiens_hsa011000.43785339
142HTLV-I infection_Homo sapiens_hsa051660.42608945
143Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.42539213
144Circadian rhythm_Homo sapiens_hsa047100.42352929
145Purine metabolism_Homo sapiens_hsa002300.41986198
146Phagosome_Homo sapiens_hsa041450.41509988
147Gastric acid secretion_Homo sapiens_hsa049710.41356100
148Folate biosynthesis_Homo sapiens_hsa007900.40706916
149Hematopoietic cell lineage_Homo sapiens_hsa046400.40530351
150Pyrimidine metabolism_Homo sapiens_hsa002400.40084384
151Homologous recombination_Homo sapiens_hsa034400.38808670
152Phenylalanine metabolism_Homo sapiens_hsa003600.37756648
153ErbB signaling pathway_Homo sapiens_hsa040120.37666563
154Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.37576145
155p53 signaling pathway_Homo sapiens_hsa041150.37252602
156MicroRNAs in cancer_Homo sapiens_hsa052060.37244021
157Arachidonic acid metabolism_Homo sapiens_hsa005900.36378921
158Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.36057813
159N-Glycan biosynthesis_Homo sapiens_hsa005100.34216528
160Alcoholism_Homo sapiens_hsa050340.32233554
161Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.30335729
162MAPK signaling pathway_Homo sapiens_hsa040100.28210634
163Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.27442970

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